Novel transcutaneous sensor combining optical tcPO2 and electrochemical tcPCO2 monitoring with reflectance pulse oximetry

Abstract

This study investigated the accuracy, drift, and clinical usefulness of a new optical transcutaneous oxygen tension (tcPO 2 ) measuring technique, combined with a conventional electrochemical transcutaneous carbon dioxide (tcPCO 2 ) measurement and reflectance pulse oximetry in the novel transcutaneous OxiVenT™ Sensor. In vitro gas studies were performed to measure accuracy and drift of tcPO 2 and tcPCO 2 . Clinical usefulness for tcPO 2 and tcPCO 2 monitoring was assessed in neonates. In healthy adult volunteers, measured oxygen saturation values (SpO 2 ) were compared with arterially sampled oxygen saturation values (SaO 2 ) during controlled hypoxemia. In vitro correlation and agreement with gas mixtures of tcPO 2 ( r = 0.999, bias 3.0 mm Hg, limits of agreement − 6.6 to 4.9 mm Hg) and tcPCO 2 ( r = 0.999, bias 0.8 mm Hg, limits of agreement − 0.7 to 2.2 mm Hg) were excellent. In vitro drift was negligible for tcPO 2 (0.30 (0.63 SD) mm Hg/24 h) and highly acceptable for tcPCO 2 (− 2.53 (1.04 SD) mm Hg/12 h). Clinical use in neonates showed good usability and feasibility. SpO 2 -SaO 2 correlation ( r = 0.979) and agreement (bias 0.13%, limits of agreement − 3.95 to 4.21%) in healthy adult volunteers were excellent. The investigated combined tcPO 2 , tcPCO 2 , and SpO 2 sensor with a new oxygen fluorescence quenching technique is clinically usable and provides good overall accuracy and negligible tcPO 2 drift. Accurate and low-drift tcPO 2 monitoring offers improved measurement validity for long-term monitoring of blood and tissue oxygenation.

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