Journal Article
Designed Ankyrin Repeat Protein (DARPin) to target chimeric antigen receptor (CAR)-redirected T cells towards CD4+ T cells to reduce the latent HIV+ cell reservoir
Lea Patasic; Janna Seifried; Valerie Bezler; Marcell Kaljanac; Irene C. Schneider; Heike Schmitz; Christiane Tondera; Jessica Hartmann; Andreas Hombach; Christian J. Buchholz; Hinrich Abken; Renate König; Klaus Cichutek
Medical Microbiology and Immunology · Vol. 209, Issue 6 · pp. 681-691 · 2020
Abstract
Chimeric Antigen Receptor (CAR)-redirected T cells show great efficacy in the patient-specific therapy of hematologic malignancies. Here, we demonstrate that a DARPin with specificity for CD4 specifically redirects and triggers the activation of CAR engineered T cells resulting in the depletion of CD4 + target cells aiming for elimination of the human immunodeficiency virus (HIV) reservoir.
Bibliographic Information
| Journal | Medical Microbiology and Immunology |
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| Publisher | Springer |
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| Publication Date | 2020-12-01 |
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| Publication Year | 2020 |
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| Volume | 209 |
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| Issue | 6 |
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| Pages | 681-691 |
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| Document Type | Journal Article |
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| Print ISSN | 0300-8584 |
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| eISSN | 1432-1831 |
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| DOI | 10.1007/s00430-020-00692-0 |
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