Journal Article
The effects of Ginsenosides on PI3K/AKT signaling pathway
Soudeh Ghafouri-Fard; Neda Balaei; Hamed Shoorei; Syed Muhammad Farid Hasan; Bashdar Mahmud Hussen; Seyedeh Fahimeh Talebi; Mohammad Taheri; Seyed Abdulmajid Ayatollahi
Molecular Biology Reports · Vol. 49, Issue 7 · pp. 6701-6716 · 2022
Abstract
Ginsenosides belong to a group of steroid glycosides that are extracted from the plant genus Panax (ginseng). This plant has been used for a long time for the treatment of a variety of disorders in traditional medicine. Recent studies have assessed the biological impact of Ginsenosides in cell culture or animal models. Animal studies have shown their beneficial impacts in the remedy of pathological conditions in different tissues. The ameliorating effects of Ginsenosides in diverse pathogenic conditions can be attributed to their effects on the production of reactive oxygen species. These substances mainly affect the activity of AMPK/AKT and PI3K/AKT pathways. The beneficial effects of Ginsenosides have been appraised in diabetes-related complications, spinal cord injury, cerebral ischemia, myocardial ischemia, and other disorders which are associated with oxidative stress. Moreover, these substances have been shown to interfere with the pathologic conditions during carcinogenesis. In the current study, we explain these impacts in two distinct sections including non-neoplastic conditions and neoplastic conditions.