Journal Article
Complete Genome Sequence of the Itraconazole Decreased Susceptible Madurella fahalii Type-Strain CBS 129176
Mickey Konings; Bert Gerrits van den Ende; Mirthe W. J. Raats; Ahmed Hassan Fahal; Wendy W. J. van de Sande; Ferry Hagen
Mycopathologia · Vol. 189, Issue 1 · 2024
Abstract
Madurella fahalii is a causative agent of the implantation mycosis mycetoma with decreased susceptibility to itraconazole, the preferred therapeutic drug to combat mycetoma. Here, we report the M. fahalii type-strain CBS 129176 genome assembly and annotation to identify a glutamic acid insert near the azole-binding pocket in the Cyp51A protein.