siRNA-Mediated Knockdown of P450 Oxidoreductase in Rats: A Tool to Reduce Metabolism by CYPs and Increase Exposure of High Clearance Compounds

Rob S. Burke; Inthirai Somasuntharam; Paul Rearden; Duncan Brown; Sujal V. Deshmukh; Martha A. DiPietro; Jillian DiMuzio; Roy Eisenhandler; Scott E. Fauty; Christopher Gibson; Marian E. Gindy; Kelly A. Hamilton; Ian Knemeyer; Kenneth A. Koeplinger; Hae Won Kwon; Traci Q. Lifsted; Karsten Menzel; Mihir Patel; Nicole Pudvah; Deanne Jackson Rudd; Jessica Seitzer; Walter R. Strapps; Thomayant Prueksaritanont; Charles D. Thompson; Jerome H. Hochman; Brian A. Carr