Journal Article
The Mechanism of Stem Cell Aging
Liangyu Mi; Junping Hu; Na Li; Jinfang Gao; Rongxiu Huo; Xinyue Peng; Na Zhang; Ying Liu; Hanxi Zhao; Ruiling Liu; Liyun Zhang; Ke Xu
Stem Cell Reviews and Reports · Vol. 18, Issue 4 · pp. 1281-1293 · 2022
Abstract
Stem cells have self-renewal ability and multi-directional differentiation potential. They have tissue repair capabilities and are essential for maintaining the tissue homeostasis. The depletion of stem cells is closely related to the occurrence of body aging and aging-related diseases. Therefore, revealing the molecular mechanisms of stem cell aging will set new directions for the therapeutic application of stem cells, the study of aging mechanisms, and the prevention and treatment of aging-related diseases. This review comprehensively describes the molecular mechanisms related to stem cell aging and provides the basis for further investigations aimed at developing new anti-stem cell aging strategies and promoting the clinical application of stem cells.