Journal Article
Evolving Therapeutic Landscape of Intracerebral Hemorrhage: Emerging Cutting-Edge Advancements in Surgical Robots, Regenerative Medicine, and Neurorehabilitation Techniques
Danyang Chen; Zhixian Zhao; Shenglun Zhang; Shiling Chen; Xuan Wu; Jian Shi; Na Liu; Chao Pan; Yingxin Tang; Cai Meng; Xingwei Zhao; Bo Tao; Wenjie Liu; Diansheng Chen; Han Ding; Ping Zhang; Zhouping Tang
Translational Stroke Research · Vol. 16, Issue 3 · pp. 975-989 · 2025
Abstract
Intracerebral hemorrhage (ICH) is the most serious form of stroke and has limited available therapeutic options. As knowledge on ICH rapidly develops, cutting-edge techniques in the fields of surgical robots, regenerative medicine, and neurorehabilitation may revolutionize ICH treatment. However, these new advances still must be translated into clinical practice. In this review, we examined several emerging therapeutic strategies and their major challenges in managing ICH, with a particular focus on innovative therapies involving robot-assisted minimally invasive surgery, stem cell transplantation, in situ neuronal reprogramming, and brain-computer interfaces. Despite the limited expansion of the drug armamentarium for ICH over the past few decades, the judicious selection of more efficacious therapeutic modalities and the exploration of multimodal combination therapies represent opportunities to improve patient prognoses after ICH.