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Integrated network pharmacology, molecular docking, and experimental validation reveal synergistic inhibition of EGFR and PI3K-Akt/JAK2-STAT3 pathways by Esculin and Esculetin to exert anti-colorectal cancer effects

Lin Liao; Zhaohui Tang; Pengfei Luo; Ruoting Tang; Hanzhi Li; Guangliang He; Jianjin Guo; Sijuan Ding
Toxicology and Applied Pharmacology · Vol. 515 · pp. 117981 · 2026
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Bibliographic Information

JournalToxicology and Applied Pharmacology
PublisherAcademic Press
Publication Date2026-10-01
Publication Year2026
Volume515
Pages117981
Document TypeJournal Article
eISSN0041-008X
DOI10.1016/j.taap.2026.117981
SubjectEnvironmental Science

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NARA Access Coverage1959-01-01~Current
Journal Homepagehttps://www.sciencedirect.com/science/journal/0041008X
Publisher PageOpen Publisher Page
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