Journal Article
Cadmium exposure enhances cell migration and invasion through modulated TRPM7 channel expression
Alison Vanlaeys; Grégory Fouquet; Philippe Kischel; Frédéric Hague; Sylvie Pasco-Brassart; Thibaut Lefebvre; Pierre Rybarczyk; Isabelle Dhennin-Duthille; Bertrand Brassart; Halima Ouadid-Ahidouch; Mathieu Gautier
Archives of Toxicology · Vol. 94, Issue 3 · pp. 735-747 · 2020
Abstract
Cadmium is a xenobiotic involved in neoplastic transformation. Cadmium enters the cells through divalent cation transporters including the Transient Receptor Potential Melastatin-related 7 (TRPM7) which is known to be involved in cancer cell fate. This work aimed to study the role of TRPM7 in neoplastic transformation induced by cadmium exposure in non-cancer epithelial cells. Non-cancer epithelial cells were chronically exposed to low-dose of cadmium. TRPM7 expression and function were studied by Western-Blot, Patch-Clamp and calcium and magnesium imaging. Finally, cell migration and invasion were studied by Boyden chamber assays. Chronic cadmium exposure induced TRPM7 overexpression and increased the membrane currents ( P P P P P
Bibliographic Information
| Journal | Archives of Toxicology |
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| Publisher | Springer |
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| Publication Date | 2020-03-01 |
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| Publication Year | 2020 |
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| Volume | 94 |
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| Issue | 3 |
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| Pages | 735-747 |
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| Document Type | Journal Article |
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| Print ISSN | 0340-5761 |
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| eISSN | 1432-0738 |
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| DOI | 10.1007/s00204-020-02674-w |
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