Journal Article
Environmental surveillance detects circulating vaccine-derived poliovirus type 2 that was undetected by acute flaccid paralysis surveillance in 2021 in Uganda
Phionah Tushabe; Josephine Bwogi; James Peter Eliku; Francis Aine; Molly Birungi; Joseph Gaizi; Lucy Nakabazzi; Theopista Kabaliisa; Irene Turyahabwe; Prossy Namuwulya; Mary Bridget Nanteza; Henry Bukenya; Christopher Kanyesigye; Edson Katushabe; Immaculate Ampeire; Annet Kisakye; Barnabas Bakamutumaho; Charles R. Byabamazima
Archives of Virology · Vol. 168, Issue 5 · 2023
Abstract
The success of the global polio eradication initiative is threatened by the genetic instability of the oral polio vaccine, which can result in the emergence of pathogenic vaccine-derived polioviruses following prolonged replication in the guts of individuals with primary immune deficiencies or in communities with low vaccination coverage. Through environmental surveillance, circulating vaccine-derived poliovirus type 2 was detected in Uganda in the absence of detection by acute flaccid paralysis (AFP) surveillance. This underscores the sensitivity of environmental surveillance and emphasizes its usefulness in supplementing AFP surveillance for poliovirus infections in the race towards global polio eradication.
Bibliographic Information
| Journal | Archives of Virology |
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| Publisher | Springer |
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| Publication Date | 2023-05-01 |
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| Publication Year | 2023 |
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| Volume | 168 |
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| Issue | 5 |
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| Document Type | Journal Article |
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| Print ISSN | 0304-8608 |
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| eISSN | 1432-8798 |
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| DOI | 10.1007/s00705-023-05759-w |
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