A rich source of new therapeutics are natural products derived from modular non-ribosomal peptide synthetases (e. g. penicillins, daptomycin). Yet, efficient bioengineering of these often gigantic megaenzymes to generate natural product analogs is a major challenge. Using synthetic zippers, we have established a co-expression strategy that not only simplifies bioengineering, but rapidly increases the biocombinatorial potential and throughput of reprogrammed NRPS.
| Journal | BIOspektrum |
|---|---|
| Publisher | Springer |
| Publication Date | 2022-06-01 |
| Publication Year | 2022 |
| Volume | 28 |
| Issue | 4 |
| Pages | 446-449 |
| Document Type | Journal Article |
| Print ISSN | 0947-0867 |
| eISSN | 1868-6249 |
| DOI | 10.1007/s12268-022-1785-7 |
| NARA Access Coverage | 2011-01-01~Current |
|---|---|
| Journal Homepage | https://www.springer.com/journal/12268 |
| Publisher Page | Open Publisher Page |