Abstract
Chronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide and a systemic chronic inflammatory disease. It is caused by factors such as aging and environmental pollution, and characterized by a dysfunction of the epithelium and immune defense. Lung organoids allow us to investigate how aging and environmental stressors impair epithelial regeneration and promote inflammation. These models enable the discovery of novel mechanisms and therapies for COPD and its associated comorbidities.