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Progressive multifocal leukoencephalopathy during 4 years of Palbociclib for advanced breast cancer with a history of follicular lymphoma patient

Ryosuke Koyamada; Mariko Nishihara; Tetsuhiro Masaki; Tomohito Shimada; Kazuhiro Ishikawa; Jun Hashimoto; Nobuyoshi Mori; Asami Namai; Hideaki Yokoo; Kenta Takahashi; Tadaki Suzuki; Kazuo Nakamichi; Shinichiro Mori
Journal of NeuroVirology · Vol. 31, Issue 2 · pp. 191-195 · 2025

Abstract

A 67-year-old woman with a history of follicular lymphoma and recurrent breast cancer with multiple metastasis developed PML during receiving fluvestrant plus palbociclib. Rituximab and bendamustine had finished 6.5 years ago. Discontinuing palbociclib and using mirtazapine, she is alive a year after diagnosis of PML. It is rare for PML to be diagnosed long after the last dose of rituximab and bendamustine. We will discuss the possible involvement of palbociclib in the course of PML.

Bibliographic Information

JournalJournal of NeuroVirology
PublisherSpringer
Publication Date2025-04-01
Publication Year2025
Volume31
Issue2
Pages191-195
Document TypeJournal Article
Print ISSN1355-0284
eISSN1538-2443
DOI10.1007/s13365-025-01255-w

Access Information

NARA Access Coverage2001-01-01~Current
Journal Homepagehttps://www.springer.com/journal/13365
Publisher PageOpen Publisher Page
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