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Physiologically based pharmacokinetic modeling for umbelliferone in rats and humans: impact of extrahepatic phase II metabolism and hepatic/gut first-pass extraction on oral bioavailability and systemic disposition

Ji-Su Kong; Seong-Wook Seo; Taeyoung Kim; Hyung Ryong Moon; Jin-Wook Yoo; Min-Soo Kim; Hwayoung Yun; Seonghwan Hwang; Ee Taek Hwang; Yunjin Jung; In-Soo Yoon
Journal of Pharmaceutical Investigation · Vol. 56, Issue 1 · pp. 185-202 · 2026
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Bibliographic Information

JournalJournal of Pharmaceutical Investigation
PublisherSpringer
Publication Date2026-01-01
Publication Year2026
Volume56
Issue1
Pages185-202
Document TypeJournal Article
Print ISSN2093-5552
eISSN2093-6214
DOI10.1007/s40005-025-00767-1

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NARA Access Coverage2012-01-01~Current
Journal Homepagehttps://www.springer.com/journal/40005
Publisher PageOpen Publisher Page
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