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Journal Article

Improved numerical stability for the bounded integer model

Sebastian Ueckert; Mats O. Karlsson
Journal of Pharmacokinetics and Pharmacodynamics · Vol. 48, Issue 2 · pp. 241-251 · 2021

Abstract

This article highlights some numerical challenges when implementing the bounded integer model for composite score modeling and suggests an improved implementation. The improvement is based on an approximation of the logarithm of the error function. After presenting the derivation of the improved implementation, the article compares the performance of the algorithm to a naive implementation of the log-likelihood using both simulations and a real data example. In the simulation setting, the improved algorithm yielded more precise and less biased parameter estimates when the within-subject variability was small and estimation was performed using the Laplace algorithm. The estimation results did not differ between implementations when the SAEM algorithm was used. For the real data example, bootstrap results differed between implementations with the improved implementation producing identical or better objective function values. Based on the findings in this article, the improved implementation is suggested as the new default log-likelihood implementation for the bounded integer model.

Bibliographic Information

JournalJournal of Pharmacokinetics and Pharmacodynamics
PublisherSpringer
Publication Date2021-04-01
Publication Year2021
Volume48
Issue2
Pages241-251
Document TypeJournal Article
Print ISSN1567-567X
eISSN1573-8744
DOI10.1007/s10928-020-09727-8

Access Information

NARA Access Coverage1973-01-01~Current
Journal Homepagehttps://www.springer.com/journal/10928
Publisher PageOpen Publisher Page
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