Polymyxins are used as last-resort antibiotics, where other treatments have been ineffectual due to antibiotic resistance. However, resistance to polymyxins has also been now reported, therefore it is instructive to characterise at the molecular level, the mechanisms of action of polymyxins. Here we review insights into these mechanisms from molecular dynamics simulations and discuss the utility of simulations as a complementary technique to experimental methodologies.
| Journal | Biophysical Reviews |
|---|---|
| Publisher | Springer |
| Publication Date | 2021-12-01 |
| Publication Year | 2021 |
| Volume | 13 |
| Issue | 6 |
| Pages | 1061-1070 |
| Document Type | Journal Article |
| Print ISSN | 1867-2450 |
| eISSN | 1867-2469 |
| DOI | 10.1007/s12551-021-00869-8 |
| NARA Access Coverage | 2009-01-01~Current |
|---|---|
| Journal Homepage | https://www.springer.com/journal/12551 |
| Publisher Page | Open Publisher Page |