Pancreatic cancer has an exaggerated dependence on mitochondrial metabolism, but methods to specifically target the mitochondria without off target effects in normal tissues that rely on these organelles is a significant challenge. The mitochondrial uncoupling protein 2 (UCP2) has potential as a cancer-specific drug target, and thus, we will review the known biology of UCP2 and discuss its potential role in the pathobiology and future therapy of pancreatic cancer.
| Journal | Cancer and Metastasis Reviews |
|---|---|
| Publisher | Springer |
| Publication Date | 2024-06-01 |
| Publication Year | 2024 |
| Volume | 43 |
| Issue | 2 |
| Pages | 777-794 |
| Document Type | Journal Article |
| eISSN | 1573-7233 |
| DOI | 10.1007/s10555-023-10157-4 |
| NARA Access Coverage | 1982-01-01~Current |
|---|---|
| Journal Homepage | https://www.springer.com/journal/10555 |
| Publisher Page | Open Publisher Page |