Journal Article
Jianpi Huayu Prescription Prevents Atherosclerosis by Improving Inflammation and Reshaping the Intestinal Microbiota in ApoE−/− Mice
Hao-Ran Zhao; Qin-Chi Xian; Xuan-Ming Zhang; Xiao-Yu Ma; Fu-Qiao Wang; Rui-Si Wang; Zhi-Jie Liu; Zhi-Gang Zhang
Cell Biochemistry and Biophysics · Vol. 82, Issue 3 · pp. 2297-2319 · 2024
Abstract
This study established an LPS-induced RAW264.7 macrophage inflammatory injury model and an AS mouse vulnerable plaque model to observe the effect of JPHYP on macrophage inflammation, plaque formation, blood lipids, inflammation levels, intestinal flora and the influence of TLR4/MyD88/MAPK pathway, and explore the anti-AS effect and molecular mechanism of JPHYP, and detected 16S rRNA of mice intestinal microbes. The difference of intestinal flora in different groups of mice was compared to further explore the intervention effect of JPHYP and clarify the molecular biological mechanism of JPHYP in preventing and treating AS by regulating TLR4/MyD88/MAPK inflammatory signaling pathway and improving intestinal flora.