Amino Acids as Targets for Immunotherapy against Solid Tumors

Abstract

The metabolism of tumor cells exerts a great influence on the tumor microenvironment (TME) of solid tumors and antitumor immune responses. Targeting molecules from the TME is an exciting strategy to overcome the ability of solid tumors to escape immunity and immunotherapies. In this sense, this manuscript delves into the complex and sometimes antagonizing role of amino acids in the TME, regulating both tumor cells and immune cells’ biology. Understanding the specific effects of different amino acids in distinct tumors can direct compelling strategies to improve antitumor therapies, especially immunotherapies.

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