Abstract
Edwardsiella piscicida ( E. piscicida ) is an important fish pathogen. However, the mechanism of Glu6P transport regulatory protein UhpA how to affect the virulence gene expression in E. piscicida is still unclear. The results in this study showed that the metabolism‐related gene expression of cysteine synthase (orf 1134) and sulphate transporter ( ych M) in the uhp A mutant strain Δ uhpA was 0.76‐fold and 0.68‐fold lower than the ones in the wild strains ( p uhp A strain was 0.80‐fold and 0.72‐fold lower than the ones in the wild strains ( p fliC and flgN in the Δ uhpA was 1.51‐fold and 1.21‐fold higher than the ones in the wild strains ( p esrB and esrC ) and T6SS ( evpB and evpC ) in the Δ uhpA was 1.27‐fold, 1.13‐fold, 1.28‐fold and 1.23‐fold higher than the ones in the wild strains ( p uhp A gene could regulate the key virulence gene expression, and the uhp A gene was associated with the pathogenicity of E. piscicida in fish.