Journal Article
Successful treatment of ceftazidime/avibactam combined with aztreonam in the NDM-producing Klebsiella pneumoniae bloodstream and intestinal infections in a NK/T lymphoma patient with agranulocytosis during autologous hematopoietic stem cell transplantation: a case report
Shiyi Liu; Qingqing Lin; Lizhi Ouyang; Chengjie Zhou; Huajun Wang
European Journal of Clinical Microbiology & Infectious Diseases · 2022
Abstract
New Delhi metallo-beta-lactamase (NDM)-producing Klebsiella pneumoniae is increasingly reported worldwide. Clinicians face significant challenges in the treatment of this multidrug-resistant bacterium. The combination of ceftazidime/avibactam (CAZ/AVI) and aztreonam (ATM) is currently probably the most effective strategy for the treatment of such infection. We described a patient diagnosed with NK/T cell lymphoma who underwent autologous hematopoietic stem cell transplantation (ASCT) in the hematology department. The patient developed severe infection after ASCT. Blood and stool cultures showed carbapenem-resistant K. pneumoniae . Blood sample was detected as NDM-producing K. pneumoniae . We successfully treated this infection with CAZ/AVI and ATM.
Bibliographic Information
| Journal | European Journal of Clinical Microbiology & Infectious Diseases |
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| Publisher | Springer |
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| Publication Date | 2022-11-12 |
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| Publication Year | 2022 |
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| Document Type | Journal Article |
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| Print ISSN | 0934-9723 |
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| eISSN | 1435-4373 |
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| DOI | 10.1007/s10096-022-04523-3 |
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