Journal Article
Klebsiella pneumoniae carrying multiple alleles of antigen 43-encoding gene of Escherichia coli associated with biofilm formation
Martina Tambassi; Elena Passarini; Ilaria Menozzi; Melissa Berni; Chiara Bracchi; Alessandra Dodi; Luca Bolzoni; Erika Scaltriti; Marina Morganti; Giulia Ferrarini; Laura Sordi; Mario Sarti; Simone Ambretti; Stefano Pongolini
European Journal of Clinical Microbiology & Infectious Diseases · Vol. 42, Issue 3 · pp. 371-377 · 2023
Abstract
A clinical strain of Klebsiella pneumoniae typed as sequence type 307 carrying three different alleles of the flu gene encoding the Escherichia coli virulence factor antigen 43 associated with biofilm formation was detected and characterized. The flu alleles are located in the chromosome inside putative integrative conjugative elements. The strain displays the phenotypes associated with Ag43, i.e. bi-phasic colony morphology and enhanced biofilm production. Furthermore, the strain produces low amount of capsule known to affect Ag43 function. Analysis of 1431 worldwide deposited genomes revealed that 3.7% Klebsiella pneumoniae carry one or two flu alleles.
Bibliographic Information
| Journal | European Journal of Clinical Microbiology & Infectious Diseases |
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| Publisher | Springer |
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| Publication Date | 2023-03-01 |
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| Publication Year | 2023 |
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| Volume | 42 |
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| Issue | 3 |
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| Pages | 371-377 |
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| Document Type | Journal Article |
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| Print ISSN | 0934-9723 |
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| eISSN | 1435-4373 |
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| DOI | 10.1007/s10096-023-04552-6 |
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