Pectin–Alginate Based Gastroretentive In-Situ Floating Gel Co-loaded with Famotidine Hydrochloride and Aceclofenac: Optimization, In-Vitro Release, and Ex-Vivo Gastric Retention Study - Kiran Dudhat; Dhruv Vaghasiya; Krupali Bhalala (Journal of Pharmaceutical Innovation, 2027)

3,5-Dicaffeoylquinic Acid Suppresses Breast Cancer Progression by Targeting TP53/cMyc/H19 Axis and Downstream MicroRNAs to Modulate MIF, Gal-3, and Gal-9 - Lolowa M. Elsherbiny; Amira Abdel Motaal; Hesham El-Askary; Tamer Manie; Rana A. Youness (Journal of Pharmaceutical Innovation, 2027)

Integrative Genomic and in silico Structural Analysis of Carbapenemase in Pseudomonas for Environmental Surveillance - Shing Wei Siew; Nazmi Harith-Fadzilah; Muhamad Arif Mohamad Jamali; Roney Miah; Mohd Fadhlizil Fasihi Mohd Aluwi; Hajar Fauzan Ahmad (Journal of Pharmaceutical Innovation, 2027)

A Machine Learning-Driven Four-Gene Signature Integrating Ferroptosis, Cuproptosis, and Immune Pathways for Diagnosis, Prognosis, and Therapeutic Guidance in Lung Adenocarcinoma - Ahmed E. Al-Sabri; Nawal M. Al-Malahi; Mohammad Talib; Mohammad Umaid; Ramalingam Karthik Raja; Rani Gul; Afrah F. Alkhuriji (Journal of Pharmaceutical Innovation, 2027)

Nose-to-Brain Targeted Mucoadhesive Nanoemulsion for Management of Schizophrenia: Development and Pharmacodynamic Evaluation - Rashmin Patel; Shivam Thakore; Jigar Vanza; Mitali Patel; Ajay Solanki; Richa Dave; Mrunali Patel (Journal of Pharmaceutical Innovation, 2027)

Fabrication, Development, and In-vitro and In-vivo Evaluation of Ciprofloxacin Hydrochloride Floating Tablets with Muco-adhesive Properties for Enhanced Gastro-retention - Fahad Y. Sabei; Awaji Y. Safhi; Ahmad Salawi; Abdullah Alsalhi; Ali Hanbashi; Kamran Ahmad Khan; Ahmed H. Albariqi; Mohammed Ail Bakkari; Hassan A. Albarqi; Abdulsalam A. Alqahtani (Journal of Pharmaceutical Innovation, 2027)

Phytochemical Profiling and Antibacterial Potential of Propolis Extract and Green Synthesis of Silver Nanoparticles: An Experimental and Computational Approach - Ateeq Ur Rahman; Mohammad Attaullah; Aqsa Gul; Robi Bibi; Bashir Ahmad; Aziz Ullah; Abdulwahed Fahad Alrefaei; Faheem Anwar; Sajid Ali (Journal of Pharmaceutical Innovation, 2027)

Hydrogel Fortified Resveratrol Nanostructured Lipid Carrier Gel: A Promising Topical Approach for Psoriasis Therapy - Surbhi S. Nagane; Anilkumar J. Shinde; Tusy Tri Wahyuni; Mohanish U. Bhoyar; Sachin S. Mali; Sudarshan Singh (Journal of Pharmaceutical Innovation, 2027)

Development and Characterization of Solid Dispersions of Azithromycin Using Poloxamer 407 and Syloid 244FP® - Sayani Bhattacharyya; LaksmiSagar S; Varsha KR (Journal of Pharmaceutical Innovation, 2027)

Exploring the Cinnamomum verum Pharmacologic Effect on Candida albicans: In Vitro and Molecular Study - Samah Hashim Albayati; Hiba Younis Khalaf; Oluwasola Michael Akinola; Wisam Fawzi Hammed; Ahmed S.M. Al-Janabi; Ahmed Hawas Abdullah; Sami Aifa; Bashar Sadeq Noomi (Journal of Pharmaceutical Innovation, 2027)

Emerging CAR-T Cell Therapies for T Cell Malignancies: Innovations, Challenges, and Future Directions - Helal F. Hetta; Fawaz E. Alanazi; Mahmoud El-Maghrabey; Salwa Qasim Bukhari; Zinab Alatawi; Kamel A. Saleh; Yasmin N. Ramadan; Ahmed A. Kotb (Journal of Pharmaceutical Innovation, 2027)

Advances in Peptide-Based Therapeutics: Formulation Strategies and Targeted Drug Delivery Systems - Pradip Karale; Saloni Borse; Anjali Gavit; Nilesh Chaudhari; Ujwal Havelikar; Raosaheb Shendge; Vipul Patel (Journal of Pharmaceutical Innovation, 2027)

Optimization and Evaluation of Aceclofenac Loaded Solid Lipid Nanoparticles via Response Surface Methodology - Khadija Saleem; Nariman Shahid; Badarqa Tul Ayesha; Alia Erum; Amna Wajdan; Kashif Barkat; Ume Ruqia Tulain; Muhammad Umer Ashraf; Sana Hanif (Journal of Pharmaceutical Innovation, 2027)

Deep Eutectic Solvent-Based In-Situ Gel Systems for Enhanced In-Vitro Ocular Permeation and Antibiofilm Activity of Gentamicin Sulphate - Nancy Thakur; Aditya Raj; Kanupriya; Bhavesh Kumar; Mansi; Arun Mahato; Nidhi S Belwal; C. Nithya Shanthi (Journal of Pharmaceutical Innovation, 2027)

Effervescent-Assisted Solid Dispersion of Itraconazole Using Soluplus: Preparation, Molecular Docking, and Simulation Studies for Enhanced Solubility, in Vitro Dissolution, and Oral Bioavailability - Darshan R. Telange; Amol S. Warokar; Ayush R. Mundada; Umesh B. Telrandhe; Ujwala Mahajan; Sachin M. More; Santosh V. Gandhi; Somdatta Y. Chaudhary (Journal of Pharmaceutical Innovation, 2027)

Computational Identification of Potential Inhibitors Targeting the YjfP Catalytic Triad in Klebsiella Pneumoniae Through Virtual Screening, Docking, and Molecular Dynamics Simulation - Arbaz Khan; Usama Ilahi; Summayya Fayaz; Fayaz Khan; Afshan Salam; Akasha Amjad (Journal of Pharmaceutical Innovation, 2027)

Solid Dispersion-Based Compression-Coated Tablets of Efonidipine Hydrochloride Ethanolate: Enhancing Dissolution and Achieving Delayed Intestinal Release - Shivani Chauhan; Kiran Dudhat; Sunny Shah; Chetan Borkhataria; Trupesh Pethani; Dhruvi Patel; Bhoomika Chaturvedi; Bhusan Patil; Mitava Patel; Dhaval Mori (Journal of Pharmaceutical Innovation, 2027)

Integrative Computational and Cellular Evidence Supporting Lactuca Sativa as a Neuroprotective Candidate for Neuropathic Pain - Nithya Vijayan; Saraswati Patel; Bhagyashree Annadurai; Gokul S (Journal of Pharmaceutical Innovation, 2027)

Doxorubicin-Postbiotic Transethosomes: Formulation and In Vitro Evaluation - Kirandeep Kaur; Preeti Patel; Balak Das Kurmi (Journal of Pharmaceutical Innovation, 2027)

Improving the Pharmacokinetic and Pharmacodynamic Profile of Levodopa Via Polymeric Nanoparticle Formulation in Experimental Parkinsonism - Bushra Riaz (Journal of Pharmaceutical Innovation, 2027)

Bergapten Induces Apoptosis and Inhibits Adhesion in MG-63 Osteosarcoma Cells via Bcl-2/Bim and Cadherin–β-Catenin Regulation - Jing Kang; Huiling Ouyang; Kai Wang (Journal of Pharmaceutical Innovation, 2027)

A GPT-Driven De Novo Discovery of SIRT2 Inhibitors Against Breast Cancer - Saad Amin; Ghadeer Mohsen Albadrani; Refka Ghodhbani (Journal of Pharmaceutical Innovation, 2027)

Correction to: Rosuvastatin-Loaded Glycerosomes as a Neuroprotective Strategy Against Hyperlipidemia-Induced Brain Dysfunction: Development, Optimization, and in vivo Evaluation - Mahran Mohamed Abd El-Emam; Mohamed Ibrahim; Milad Reda Qelliny; Mahmoud Mostafa; Marwa Mohamed El Sayed; Maha S. Kilany; Amira Ebrahim Alsemeh; Rania Said Moawad; Mohamed Fouad Mansour (Journal of Pharmaceutical Innovation, 2027)

Exploring the Dissolution-enhancement Functionality of Poloxamer 407 in Cilostazol Tablets Prepared by Different Manufacturing Techniques - Obada Mahmoud Sawafta; Alia Kh. AlSuwais; Mohammed rohi Sanoufi; Suzan Yousef Obied; Asaad Shahin; Ahmad Aljaberi (Journal of Pharmaceutical Innovation, 2027)

Structure-Guided Design, Synthesis, and Computational–Experimental Validation of Imidazo[1,2-a]pyridine–1,3,4-Thiadiazole Hybrids as Multitarget Antifungal Agents Against Mucormycosis - Neela M. Bhatia; Smita Tukaram Kumbhar; Priyanka J. Anbhule; Manish S. Bhatia (Journal of Pharmaceutical Innovation, 2027)

HPLC-PDA-MS/MS Profiling, In Vitro and In Vivo Evaluation of Melilotus indicus Stem Extract: Insights Into its Antioxidant and Hepatoprotective Mechanisms for Potential Therapeutic Applications - Ibtissem Nafti; Anouar Feriani; Nihad Sahri; Meriam Tir; Ezzeddine Saadaoui; Walid Elfalleh; Hamdi Bendif; Shakilur Rahman; Mansour Sobeh; Nizar Tlili (Journal of Pharmaceutical Innovation, 2027)

Qualitative Versus Quantitative Risk Assessment in Good Manufacturing Practice (GMP) Audits: How European-Based Auditors Interpret Probability Under International Council for Harmonisation Guideline (ICH) Q9 (R1) - Dorna Sheikhi; Janine Marie Traulsen (Journal of Pharmaceutical Innovation, 2027)
Purpose Under ICH Q9 (R1), risk is defined as a function of probability and severity of harm. Although probability may be expressed quantitatively, little empirical evidence exists regarding how EU GMP auditors assess probability in practice. This study explored probability assessment approaches among auditors and the use of qualitative and quantitative methods. Methods A descriptive cross-sectional questionnaire was administered to 52 EU-based GMP auditors with at least two years of auditing experience. Participants (21 in total) completed structured multiple-response questions on probability and optional free-text comment fields addressing probability assessment practices (response rate: 40.4%). Data were analysed using descriptive statistics and cross-tabulation; no inferential analyses were performed. Results Qualitative probability assessment approaches were the most frequently reported method (14/21), while 8/21 respondents reported using quantitative approaches (multiple responses permitted). Probability assessment was commonly described as context-dependent and informed by professional judgement rather than purely numerical models. Qualitative approaches were reported across all experience categories and levels of English proficiency. Participants highlighted limited availability of robust historical data, contextual complexity, and reliance on prior audit experience as key factors influencing probability assessment. Respondents (4/21) suggested that no single clear definition of probability assessment was consistently applied in practice. Conclusion Although some participants reported using quantitative approaches, probability assessment remained predominantly qualitative and experience-based in audits. Participants frequently described using structured risk matrices and categorical probability scales (e.g., High/Medium/Low) to support probability assessments. The findings highlight variability in how probability is operationalised and suggest that additional practical guidance may be useful.

Innovative Nanocarrier-Based Topical Delivery of Phytoconstituents for Atopic Dermatitis: Formulation Advances, Clinical Evidence, and Patent Landscape - Ankita Sahu; Manju Rawat Singh; Bina Gidwani; Veenu Joshi; Anand Murti Mishra; Akhlesh Jain; Suresh Thareja; Amber Vyas (Journal of Pharmaceutical Innovation, 2027)

Crosslinker-Free Sodium Alginate/Cellulose Nanocrystal/PVA Composite Sponges as Tunable, Cytocompatible Macromolecular Carriers for Controlled Tetracycline Delivery in Wound Healing - Narkhede Minal; Wankhede Nilesh; Daware Omkar; Minal Narkhede; Omkar Daware (Journal of Pharmaceutical Innovation, 2027)

Development Analysis and Strategic Insights from a 505(b)(2) Reformulation Product: Enzalutamide - Jinkun Zhang; Shuyan Wu; Anrong Jiang; Dailong Fang (Journal of Pharmaceutical Innovation, 2027)

Decoding MLK4 Inhibition with Interpretable Machine Learning: Identification of a Novel Dihydroimidazopyridine-Based Promising Lead Compound - Afnan Alzaghari; Safa Daoud; Husam Nassar; Mamon Hatmal; Mutasem O. Taha (Journal of Pharmaceutical Innovation, 2027)

Enhancing Solubility and Controlled Release of Mefenamic Acid via Carboxymethyl-β-Cyclodextrin Encapsulation - Azita Khodabandeh-Baygi; Behnam Mahdavi; Esmail Rezaei-Seresht; Majid Mohammadhosseini (Journal of Pharmaceutical Innovation, 2027)

In Silico Exploration of Novel EGFR T790M and C797S Resistance with Mutant-Selective Allosteric Inhibitors Using a Hybrid Computational Approach - Mahadevi Vitthal Kendre; Sachin S. Bhusari; Pravin S. Wakte (Journal of Pharmaceutical Innovation, 2027)

Green Synthesis and Characterization of ZnO Nanoparticles from Cynoglossum microglochin Extract with Broad Spectrum Antioxidant, Antileishmanial, Antibacterial and Anticancer Activities - Beenish Kalsoom; Ishtiaq Hassan; Abdul Basit; Ikram Ullah; Muhammad Tariq; Manan Khan; Inam Ullah (Journal of Pharmaceutical Innovation, 2027)

Advancing Fisetin Delivery via Cubosomes: Enhanced Cellular Absorption in A549 Lung Cancer Cells and Reduced Inflammatory Toxicity in Swiss Albino Mice - Tukaram Kedar; Rupali Katkar; Sunil Jalalpure; Bhaskar Kurangi; Reshma Karishetti (Journal of Pharmaceutical Innovation, 2027)

Development and Evaluation of a Lapatinib-Loaded Lipomer Formulation for Pulmonary Drug Delivery - Nigar Kadar Mujawar; Jameel Ahmed S. Mulla (Journal of Pharmaceutical Innovation, 2027)

Mechanistic Insights into Supersaturation Control of Itraconazole Amorphous Solid Dispersions Under Physiological Hydrodynamics: An Experimental and Computational Study - Dilpreet Singh (Journal of Pharmaceutical Innovation, 2027)

Development and Optimization of a Stable Parenteral Formulation of Relugolix to Overcome Oral Bioavailability Limitations in the Management of Prostate Cancer - Priyanka Nagar; Robin Kumar; Shilpa Chaudhary; Amit Kamboj; Minakshi Garg (Journal of Pharmaceutical Innovation, 2027)

Does Route of Administration Matter for Gepant Safety? A Comparative Disproportionality Analysis of Intranasal Zavegepant Using the FDA Adverse Event Reporting System - Martina Giacon; Salvatore Terrazzino (Journal of Pharmaceutical Innovation, 2027)
Background Zavegepant shares a pharmacological target with oral gepants but has distinct pharmacokinetics and a unique intranasal route. While oral safety profiles are well defined, the real-world impact of the intranasal route on systemic sparing effects remains under-investigated. This study compared the real-world safety profiles of zavegepant and oral gepants. Methods We performed a disproportionality analysis using the FDA Adverse Event Reporting System (FAERS) from April 2023 to September 2025. Zavegepant was compared with a pooled cohort of oral gepants (rimegepant, ubrogepant, atogepant) and with rimegepant individually. Robust signals of disproportionate reporting (SDRs) were defined using the Bayesian Information Component lower bound (IC025 > 0). Results The analysis revealed a clear safety dichotomy. Zavegepant was associated with a “mucosal injury signature,” showing robust SDRs for nasal discomfort (IC025 = 2.94), throat irritation (2.38), vomiting (1.11), and dysgeusia (4.44). In contrast, rimegepant showed robust SDRs for Raynaud’s phenomenon (1.53) and somnolence (0.75). The pooled oral class exhibited a systemic profile dominated by functional gastrointestinal disorders (constipation IC025 = 0.81, dyspepsia IC025 = 0.71) and vascular events. Notably, none of these systemic signals emerged as robust SDRs for zavegepant. Conclusions While associated with local toxicity, zavegepant appears to offer a potential “systemic sparing” profile, avoiding the constipating and vascular reporting signals linked to oral CGRP blockade. These findings are strictly hypothesis-generating and warrant epidemiological confirmation. Appropriate pharmacoepidemiological studies are required before formal clinical guidelines can be established.

Novel Azithromycin-Based Re-Dispersible Mucoadhesive Gargle for Effective Management of Bacterial Throat Infections: In Vitro and In Vivo Characterization - Debaprasad Dash; Kapil Raju Shah; Ajit Mishra; Jitu Halder; Rakesh Kumar Sahoo; Tushar Kanti Rajwar; Deepak Pradhan; Ritu Mahanty; Bibhanwita Satpathy; Ivy Saha; Priyanka Dash; Chandan Das; et al. (Journal of Pharmaceutical Innovation, 2027)

Multi-Target Analysis of Xanthone Derivatives as Potential Anti-Trypanosoma cruzi Agents: An Integrated Computational Screening - Rafael de Oliveira Marinho; Caroline do Nascimento Gonçalves; Jacilene Silva; Alice Maria Costa Martins; Emmanuel Silva Marinho (Journal of Pharmaceutical Innovation, 2027)

Epigallocatechin Gallate (EGCG)-Loaded Hydrogel for Topical Chronic Non-Communicable Skin Inflammation - Hala Shokr; Mandeep Marwah; Mohamad Anas Al Tahan; Oskar Popek; Lissette Sanchez-Aranguren (Journal of Pharmaceutical Innovation, 2027)
Purpose Chronic non-communicable inflammatory skin disorders involve persistent immune activation, oxidative stress, and impaired repair. Conventional topical agents such as corticosteroids often cause adverse effects with long-term use. Epigallocatechin-3-gallate (EGCG), a potent antioxidant and anti-inflammatory polyphenol, shows therapeutic potential but is limited by poor stability and permeability. Hydroxypropyl methylcellulose-based hydrogels (HPMC-gel) offer a biocompatible platform for topical drug delivery with sustained release. Methods EGCG-loaded HPMC gels were formulated with or without 10% propylene glycol (PG). Differential Scanning Calorimetry assessed thermal stability. Release behaviours were measured in a permeable insert system using High-Performance Liquid Chromatography with Ultraviolet Detection (HPLC-UV). Cytocompatibility was tested via XTT assay on EA.hy926 endothelial cells and human dermal fibroblasts. Cellular uptake, cytokine modulation, and ROS levels were quantified following tumour necrosis factor-alpha (TNF-α) stimulation to simulate inflammatory conditions. Results EGCG exhibited cytocompatibility up to 0.5 µM in both cell types. Differential Scanning Calorimetry (DSC) revealed a higher glass transition temperature in EGCG-HPMC gels compared to plain HPMC. The gel formulations provided sustained EGCG release over six hours, with PG-containing gels showing moderately increased permeation. Cellular uptake studies demonstrated significantly higher intracellular EGCG levels from gel + PG formulations compared to solution or gel alone ( p Conclusion The EGCG-HPMC gel demonstrated favourable biocompatibility, enhanced stability, sustained release, and robust anti-inflammatory, antioxidant, and matrix-modulating effects in vitro. This biocompatible formulation offers a promising topical therapy for chronic inflammatory skin disorders.

RP-HPLC Method for Simultaneous Quantification of Captopril and Hydrochlorothiazide in a Bilayer Multi-unit Pellet System - Melroy D’Sa; Nitesh Kumawat (Journal of Pharmaceutical Innovation, 2027)

Antimicrobial and Anti-inflammatory Potential of Thermoresponsive In situ Gel Loaded with Metronidazole Microsponges for Localized Treatment of Periodontitis - Eman S. Abd El-Reheim; Khaled M. A. Hassanein; Helal F. Hetta; Niveen G. Elgendy; Gamal Eldin A. Elgendy; Abd Elrazaq A. Mohamed; Noura H. Abd Ellah (Journal of Pharmaceutical Innovation, 2027)

Harnessing Kruppel-like Factor 4 for Glioblastoma Immunotherapy: A Multiepitope Subunit Vaccine Design Approach - Faisal Ahmad; Hassan Ayaz; Taghreed N. Almanaa; Naveera Khan; Adnan Zeb; Sajjad Ahmad; Hajra Ahmad; Nabila Naeem; Sarim Zafar; Yasir Waheed; Saeed Ullah Khattak (Journal of Pharmaceutical Innovation, 2027)

Design and Optimization of Hydroxypropyl Beta-Cyclodextrin-Based Miconazole Nitrate Nanosponges Gel for Enhanced Transungual Drug Delivery - Dhanashri Jadhavar; Manoj Shinde; Varsha Mane; Priyanka More; Laxmikant Deshmane (Journal of Pharmaceutical Innovation, 2027)

A Concise Alternative Process to Melphalan Flufenamide Hydrochloride - Sandip R. Patil; Pradip N. Patil; Ganesh Urunkar; Tushar Khaladkar; Kaivalya G. Kulkarni; Kiran R. Patil; Sharad R. Patil (Journal of Pharmaceutical Innovation, 2027)

Sphingosine-1-Phosphate Signaling and Nanocarrier-Based Topical Therapeutics in Plaque Psoriasis - Vasanth Kumar Mohan; Rajaganapathy Kaliyaperumal (Journal of Pharmaceutical Innovation, 2027)

From Detection to Prediction: AI-driven Process Analytical Technology for Nitrosamine and NDSRI Control in Pharmaceuticals - Sanskruti Shirsat; Priyanka Kandhare; Mugdha Suryawanshi; Atmaram Pawar (Journal of Pharmaceutical Innovation, 2027)

Rapid detection of LMBV using rabbit-derived single-chain antibodies via fluorescent immunochromatography assay - Zhou Chen; Jun-Yao Xia; Tian-Zi Sun; Mao-Lin Liu; Jia-Lun Tang; Zhao Zhao; Bin Zhu (Aquaculture, 2027)

Development and validation of a new SYBR green-based qPCR assay for the broad detection of Novirhabdovirus salmonid (IHNV) genotypes - Sungjae Ko; Eunsu Song; Magdalena Stachnik; Bertrand Collet; Bartolomeo Gorgoglione; Po-Tsang Lee; Alejandro J. Yáñez; Joon Bum Jeong; Kwangil Kim; Youngchul Kim; Dimitri Rigaudeau; Mun Gyeong Kwon; et al. (Aquaculture, 2027)

The combined effects of salt feed, photoperiod, and temperature on Atlantic salmon smolt physiology, migratory behaviour, and sexual maturation - Lars Eirik Myklatun; Antony J. Prabhu Philip; Angelico Madaro; Audun Ø. Pedersen; Thomas W.K. Fraser; Trygve Sigholt; Tom J. Hansen; Birgitta Norberg; Sigurd Stefansson; Per Gunnar Fjelldal (Aquaculture, 2027)

Performance assessment of starchy liquid modified natural hydraulic lime mortar for carbon sequestration - Nisha Sankar; Ravi Ramadoss (European Journal of Environmental and Civil Engineering, 2026)

Synergic effect of waste brick powder, waste ceramic powder and marble powder on rheological behaviour, mechanical behaviour and carbon footprint of binary and ternary mortars - Brahim Soudani; Hamza Soualhi; Akram Salah Eddine Belaidi; Salim Safiddine; Tien-tung Ngo; Nasreddine Nasri (European Journal of Environmental and Civil Engineering, 2026)

Accuracy of building code formulations in predicting shear strength of exterior RC beam-column joints - Teklewoin Haile Fitwi; Giovanna Xotta; Flora Faleschini (European Journal of Environmental and Civil Engineering, 2026)

Aeolian erosion processes of iron oxides in desert environments: insights from grain-size controlled mineralogy and magnetic susceptibility in the Kumtagh Desert - Jian Yu; Hanzhi Zhang; Bo Wu; Bingfu Jin; Eerdun Hasi; Zhizhu Su; Deyong Kong; Xujiao Han (Aeolian Research, 2026)

Assessment of the concentrations of heavy metals and major elements in soil and the atmospheric dust of urban and non-urban environments in Sistan region of Iran - Abbas Miri; Ebrahim Shirmohammadi (Aeolian Research, 2026)

Threshold-dominated deceleration of Aeolian activity in the Badain Jaran Sand Sea: the role of reduced strong wind events and local thermal control - Yang Qinghua; Cheng Hongyi; Zhao Liqiang; Yang Linhai; Liu Yi (Aeolian Research, 2026)

Feldspar luminescence tracks dust sources in southern South America - Diego Montecino-Jara; André O. Sawakuchi; Thays D. Mineli; Nicolás J. Cosentino; Victoria Nogués; Gabriela Torre; Diego M. Gaiero (Aeolian Research, 2026)

Morphological characteristics and formation mechanism of Yardangs in Guazhou, lower Shule River of Hexi corridor, northwestern China - Liying Guo; Yinzhou Huang; Zhi Sun; Yang Liu; Guoqiang Ma (Aeolian Research, 2026)

Dust emission predictions in a semi-arid region with improved characterization of vegetation and salt crust coverage - Ty R Hosler; Bradley R Adams; Isaac J Sudweeks; Mark H Radwin; Hosein Foroutan (Aeolian Research, 2026)

Inter- and intra-annual variations in Saharan dust fluxes in the eastern Mediterranean Sea and their connection to carbon export - Anouk P.E. van Boxtel; Addison Rice; Constantijn Kurpershoek; Tijno de Nooij; Gert J. de Lange; Francien Peterse; Jan-Berend W. Stuut (Aeolian Research, 2026)

Directionality of mineral dust arriving in the alpine Critical Zone, Uinta Mountains, Utah, USA - Jeffrey S. Munroe (Aeolian Research, 2026)

Flow structure and sand deposition mechanisms of nested checkerboard barriers in desert railway - Guowei Xin; Youchun Ding; Yanlu Qi; Jianhua Xiao; Guanghui Tang; Jie Zhang (Aeolian Research, 2026)

Multi-criteria evaluation of zeolite-enhanced MICP for wind erosion control: Balancing mechanical strength, ammonium removal, and seed germination - Maryam Naeimi; Jian Chu; Saeed Shams (Aeolian Research, 2026)

Parameterization of dead vegetation effects on dust emission using soil tillage index in an offline meteorology-chemistry model - Ieong-in Kaman Kong; Mizuo Kajino; Yaping Shao; Jing Wu; Kei Kawai; Tsuyoshi Thomas Sekiyama; Takashi Maki; Yasunori Kurosaki; Masahide Ishizuka; Banzragch Nandintsetseg; Masato Shinoda; Batjargal Buyantogtokh; et al. (Aeolian Research, 2026)

Suspended aeolian sand transport across a remobilized coastal dune system, Zuid-Kennemerland, The Netherlands - O. Verhage; S.M. Arens; C.J. Beets; J.B.W. Stuut; G. van Zijl; M.A. Prins (Aeolian Research, 2026)

The influence of surface crust dynamics and sediment availability on aeolian dust emission from ephemeral lake beds: evidence from Etosha Pan, Namibia - Natasha S. Wallum; Giles F.S. Wiggs; Rosemary A. Huck; Jenifer A. Leidelmeijer; Harland L. Goldstein (Aeolian Research, 2026)

AI-enhanced categorisation and analysis of dune patterns in the south-western Kalahari - Maike Nowatzki; David S.G. Thomas; Richard M. Bailey (Aeolian Research, 2026)

The impact of wind erosion on the transport and enrichment of microplastics in arid lands - Kazem Nosrati; Kazem Taherinezhad-Javazm; Peter Fiener (Aeolian Research, 2026)

Geochemical fingerprinting and source apportionment of deposited African dust in southwestern Europe using elemental ratios and receptor modelling - Jorge Pey; Blas L. Valero-Garcés; Juan Cruz Larrasoaña; Jesús Causapé; Inés de la Parra; Jesús Reyes; Sonia Castillo; Noemí Pérez; Belén Oliva; José Carlos Cerro; Kilian Jungkeit; María Pilar Mata (Aeolian Research, 2026)

Polonium-210 contamination in marine bivalves from tropical coastal waters of Vietnam: Implications for environmental biomonitoring and ecological risk assessment - Van-Hao Duong; Thanh-Xuan Pham-Thi; Thanh-Nam Nguyen; Hue Nguyen Thanh Kim; Trung-Tien Chu (Marine Pollution Bulletin, 2026)

Spatiotemporal dynamics of microplastic accumulation and biodeposition mediated by the Pacific oyster (Crassostrea gigas) in coastal aquaculture - Guang Yang; Xin Wang; Xingyu Wei; Xi Chen; Yifan Cao; Wenxin Gao; Kexin Zhu; Zhihua Feng (Marine Pollution Bulletin, 2026)

Effects of accumulation of acrylic microfibers on algal ingestion, growth, and survival of spat of slipper-cupped oyster Magallana billeneata (Röding 1798) - L.C. Insigne; M. Hecker; S.M. Cragg; E.G. Dizon; R. Rodolfo; R.P. Ruado; D.F.L. Onda (Marine Pollution Bulletin, 2026)

Aged polystyrene nanoplastics and bisphenol A co-exposure impair mitochondrial respiration in juvenile horseshoe crab Tachypleus tridentatus - Kangping Jiao; Youji Wang; Yuntian Shi; Moslem Sharifinia; Nisha Singh; Khor Waiho; Hanafiah Fazhan; Jae-Seong Lee; James Kar-Hei Fang; Kit Yue Kwan; Marta Sendra; Menghong Hu (Marine Pollution Bulletin, 2026)

Concentrations of polychlorinated biphenyls and toxic metals in short-tailed shearwaters following a mass mortality event - Eliza Hamilton; Richard B. Banati; Thomas E. Lockwood; David P. Bishop (Marine Pollution Bulletin, 2026)

Pollution characteristics, risk assessment, and environmental associations of microplastics and antibiotic resistance genes in tropical marine aquaculture: A comparative study across different farming systems in Hainan - Yanru Kang; Yongqiang Qin; Nan Chen; Shaobai Wen (Marine Pollution Bulletin, 2026)

Macroalgal tissue nutrients coupled with bacterial assays suggest persistent highly derived nitrogen inputs in an urbanized estuary in Charleston, South Carolina - Christopher J. Carbon; Heather Fullerton; Heather L. Spalding (Marine Pollution Bulletin, 2026)

Integrated chemical and effects-based assessment of sediment contamination in the Saemangeum coastal area, South Korea - Songyeon Lee; Jiyun Gwak; Jihyun Cha; Junghyun Lee; Jae Joong Kang; Sunggyu Lee; Kongtae Ra; Jong Seong Khim; Seongjin Hong (Marine Pollution Bulletin, 2026)

Transboundary marine debris and its impacts on an Amazonian tourist beach - Jenny Márcia Pereira Luz; Luci Cajueiro Carneiro Pereira; Brenda Ribeiro Padilha da Silva; Gina Peña-Villacreses; Ingrid Niemes de Souza; Luciane Ferreira da Silva Assis; Rauquírio Marinho da Costa (Marine Pollution Bulletin, 2026)

Multifaceted toxicity of dimethoate in the Pacific oyster (Magallana gigas): Biochemical, molecular, and physiological responses - Dalya Belhassen; Roberto Martins; Safa Bejaoui; Diogo N. Cardoso; Joana Figueiredo; Ana Rita R. Silva; Rym Baati; Nejla Soudani (Marine Pollution Bulletin, 2026)

Anthropogenic river management drives decadal shifts in organic carbon sequestration in the Yellow River Estuary - Xiaotian Liu; Xiaosong Zhong; Zongqing Lv; Xiangbin Ran (Marine Pollution Bulletin, 2026)

Spatio-temporal modulation of deep pass and shallow channel oceanic inflows on the lagoon renewal time of three pearl farming atolls (French Polynesia) - Romain Le Gendre; Sébastien Petton; Oriane Bruyère; Martine Rodier; Serge Andréfouët (Marine Pollution Bulletin, 2026)

Integrated physiological, transcriptomic, and metabolomic analyses provide new insights into hypoxia tolerance in large yellow croaker (Larimichthys crocea) - Yibo Zhang; Jie Ding; Xuelei Wang; Ran Meng; Songpeng Jia; Xiongfei Wu; Junquan Zhu; XiaoMing Peng; Weiliang Shen (Marine Pollution Bulletin, 2026)

Quantifying surface topography helps reveal the combined effects of microplastics UV-aging and organic matter on trace metal adsorption in seawater - Petra Vukosav; Ana Rapljenović; Sunčana Geček; Ivan Vukosav; Vlado Cuculić (Marine Pollution Bulletin, 2026)

Identifying wastewater pollution hotspots in coastal Hawaiian waters with high freshwater inputs - Joseph W.P. Nakoa; Tracy N. Wiegner; Steven L. Colbert; Karla J. McDermid; Shayla M.P. Waiki; Nicholas M. Storie; Devon K. Aguiar; Craig E. Nelson (Marine Pollution Bulletin, 2026)

Genotoxicity and hematological biomarkers in Mugil sp. from a PAH-contaminated urban estuary in Pernambuco, Brazil - Vivian Costa Vasconcelos; Juliano Gomes de Souza; Josiane Ramos da Silva; Maria Angélica da Silva; Guilherme Melgaço Heluy; Glauber Pereira de Carvalho Santos; Romero Marcos Pedrosa Brandão Costa; Gilvan Takeshi Yogui; Bruna Emanuelle Gomes do Nascimento; Juliana Ferreira Santos; Ranilson de Souza Bezerra (Marine Pollution Bulletin, 2026)

Decadal stability and forensic reliability of petroleum biomarkers in tropical coastal environments: Validating laboratory kinetics against 10-year field residues - Ying-Ju Chang; Cheng-Ting Lin (Marine Pollution Bulletin, 2026)

A dissolved oxygen inversion method based on multi-source spectral-spatial feature fusion and recursive feature elimination - Lianwei Li; Lin Cheng; Cunjin Xue; Baojian Sun; Yu Wang (Marine Pollution Bulletin, 2026)

Purifying a corrosive hydrocarbon-degrading Shewanella indica from iron rust in oil-containing seawater: Understanding of microbial corrosion mechanisms based on whole genome analysis - Ding Guo; Yimeng Zhang; Xiaofan Zhai; Jizhou Duan (Marine Pollution Bulletin, 2026)

Four-band narrowband CMOS imaging system optimized for robust marine litter classification - Ye Min Htay; Ahmad Shaqeer Mohamed Thaheer; Yukihiro Takahashi; Shin'ichiro Kako (Marine Pollution Bulletin, 2026)

A novel time-aware attention-enhanced transformer to prediction harmful algal Bloom's occurrence - Liye Song; Shengjun Xu; Jingyu Lin; Zhihui Bai (Marine Pollution Bulletin, 2026)

Governing specimen-based biodiversity research in marine protected areas: A Mediterranean framework for policy and practice - Hayfa Chammem; David Verdiell-Cubedo; José Galián (Marine Policy, 2026)

Challenges for a sustainable blue economy: A comparative analysis of resilience and coastal governance in Southern Europe - Lisa A. Pace; Hugo Pinto (Marine Policy, 2026)

From local harvest to import dependence: Value chain transformation, IUU fishing, and traceability feasibility in a small island developing state lobster fishery - Ameer Ebrahim; Kettyna Gabriel; Siddharth Motwani; Annie Vidot; Sabrena Lawrence; Carmen Revenga (Marine Policy, 2026)

Reconciling Ostrom and Indigenous approaches to collective right-led governance: Insights from the rule-centric example of Aotearoa New Zealand’s Pare Hauraki Collective redress process - S. Awatere; N. Harcourt; C. Royal; D. Hikuroa; S. Ogilvie (Marine Policy, 2026)

Do positive perceptions of aquaculture’s socioeconomic benefits counteract negative views of its environmental impacts? The case of mussel farming in Chile - Manuel Villalba; César Salazar; Marcela Jaime (Marine Policy, 2026)

Towards inclusive digital traceability in fisheries: Expert perspectives and the European Union regulatory framework - Gisela Costa; Cristina Pita; Mafalda Rangel (Marine Policy, 2026)

Gendered resilience in India’s seaweed farming: Highlighting policy lessons from the COVID-19 pandemic for inclusive Blue economy framework - Sundaram Swathi Lekshmi Perumal; Radhakrishnan Kalidoss; Gopal Nikita; D. Divu; Mojjada Suresh Kumar; V.P. Vipin Kumar; George Saju; S. Surya; R. Narayanakumar; Kingsly Jose; V.A. Leslie; S.S. Arabindoo; et al. (Marine Policy, 2026)

Exploring the prospects for a shared vision of offshore wind energy at the national level - Jamie Jenkins; Maria Malho; Jenni Kilpi; Kari Hyytiäinen (Marine Policy, 2026)

User habits and public perceptions of sunscreen pollution: A global review and case study of Britain’s Ocean City - Anneliese A. Hodge; Elizabeth Gabe-Thomas; Frances E. Hopkins; Mahasweta Saha; Awadhesh N. Jha (Marine Policy, 2026)

The gender gap in fisheries and climate policy: Insights from Southeast Asia - Danielle Robinson; Tyas Ismi Trialfhianty; Ben Charo; Helen E. Fox; Alice Joan Ferrer; Maria Beger (Marine Policy, 2026)

Inclusive and equitable cooperation in BBNJ implementation: A comparative analysis of institutional design - Oliver Tiliouine; Ricardo De Ycaza; Elizabeth Mendenhall; Vui Gemma Nelson; Yoshitaka Ota (Marine Policy, 2026)

From classroom to policy: Lessons from the Blue School stakeholder network - Raquel Lorenz Costa; Cláudia Faria (Marine Policy, 2026)

Evolution of environmental governance and its effectiveness in the Baltic Sea: A systematic literature review - Jamie Jenkins (Marine Policy, 2026)

Implementing the BBNJ Agreement: From flag States to the home States of individuals and corporations conducting activities at sea - Eduardo Cavalcanti de Mello Filho (Marine Policy, 2026)

Building a sustainable and higher-value seafood sector: Insights from a stakeholder dialogue in the Scottish value chain - Nazli Koseoglu; Phoebe Somervail; Tareq Mzek; Simone Piras (Marine Policy, 2026)

Understanding coastal governance and climate adaptation processes through social conflicts: Theoretical and methodological approaches - Mathilde Luna Joly; Kristof Van Assche; Giulia Galluccio (Marine Policy, 2026)

A review of the toxic effects of heavy metals potentially released from deep-sea mining: From individuals to ecosystems - Zhen Zhong; Baishun Liang; Lilan Zhang; Dong Sun (Marine Policy, 2026)

Ocean as a space of rights for whales - Snjólaug Árnadóttir (Marine Policy, 2026)

From regulation to relationship: Values-lead ocean governance through beauty, love, and abundance - Larelle Bossi (Marine Policy, 2026)

Second-order memristor-coupled heterogeneous neuron model: multi-attractor, multi-stability, and hardware implementation - Miao Xie; Hairong Lin; Qiuzhen Wan; Fei Yu; Wei Yao (Cognitive Neurodynamics, 2026)

High-accuracy EEG-based driver fatigue detection using feature-coupled tensor decomposition for multimodal brain connectivity analysis - Tian Yan; Hechong Su; Zengyao Yang; Aimin Zhang; Yidan Ma; Xiaolong Wang; Yue Wu; Li Yan; Yichen Wang; Jianfu Cao (Cognitive Neurodynamics, 2026)

A dual-input fuzzy parameter zeroing neural network for robust synchronization of chaotic systems - Lv Zhao; Chen Zhu; Jie Jin (Cognitive Neurodynamics, 2026)

Seismic reservoir characterization of deep carbonates under complex overburden: a lithofacies-association zonation workflow, Longwangmiao Formation, Sichuan Basin - Lei Tan; Yuanzhi Zhou; Junliang Li; Linzhi Zhang; Ya Zhang; Pingchao Fang; Minzhi Zhang; Bowen Liu; Longyan Yin; Lin Qiao; Mingzhi Kuang; Hong Liu (Carbonates and Evaporites, 2026)

Understanding gendered aspirations, decision-making, and fruit tree preferences in Makueni County, Kenya - Michelle Cohen; Mary Crossland; Eefke Mollee; Geneviève Laroche; Agnes Gachuiri; Denis Wakaba; Catherine Muthuri (Agroforestry Systems, 2026)
In Makueni County, Kenya, smallholder farmers face erratic rainfall, severe droughts, recurrent floods, and water scarcity due to climate change. Understanding farmers’ aspirations is therefore essential to ensuring that support is relevant and responsive. This study explored: (1) farmers’ aspirations for farm composition, particularly fruit tree species, and potential changes in response to market and climate shifts; (2) gender dynamics shaping fruit tree cultivation decisions; and (3) connections between cultivated species, aspirations, and decision-making across gender and age. Data collected via focus group discussions, semi-structured interviews and key informant interviews revealed a shift towards fruit-tree-based livelihoods, ostensibly offering improved food and income security and reduced labour. However, this shift, dominated by a few exotic species, may reduce farm- and landscape-scale species diversity. Decision-making was strongly gendered: men dominated species selection and management and controlled large-scale sales of higher-value fruit, owing to land ownership, knowledge and cultural norms, while women held greater power over small-scale sales, lower-value species and the income these generated. To foster equitable, resilient farming systems, we recommend inclusive, gender-responsive fruit tree production and management training. Transforming gender relations to amplify women’s voices in species selection could diversify fruit tree portfolios and lead to more equitable and biodiverse farming systems.

Multi-element stoichiometric regulation and nutrient coupling in karst agroforestry systems: implications for sustainable land management - Shujie Chen; Yuanyang Chen; Xiaoling Zeng; Chuan Jiang; Xiuhao Yang; Wanglan Tao; Manlian Wang; Jun Ren; Fuzhao Huang; Chenggang Liu (Agroforestry Systems, 2026)

Beyond forest boundaries: trees outside forests, climate resilience and geospatial intelligence in Uttar Pradesh, India - Arun Pratap Mishra (Agroforestry Systems, 2026)

Associations between cranio-mandibular shape and bite force in the bank vole (Clethrionomys glareolus): effects of age and sex - Matej František Čalfa; Alexander Csanády (Zoomorphology, 2026)

Thermoeconomic Performance of a Single-Slope Solar Still Integrated with High-Frequency Ultrasonic Atomization and Wire-Mesh Packing - Ahmed A. Al-Nagdy; Gamal B. Abdelaziz; Ibrahim S. Mahmoud; Emad M. S. El-Said (Water Conservation Science and Engineering, 2026)

Correction: Detection of circovirus and herpesvirus co-infection in suddenly dead common ravens (Corvus corax) - Aleksandra Ledwoń; Rafał Sapierzyński; Beata Dolka; Dorota Witkowska; Małgorzata Gbylik-Sikorska; Bartosz Sell (Veterinary Research Communications, 2026)

Genomic characterization of multidrug-resistant Salmonella Choleraesuis ST145 isolated from a pig in South Korea and its phylogenomic relationship to global lineages - Hee-Seung Kang; Md. Sekendar Ali; Bo-Youn Moon; Min-Young Kim; Hyeon-Jung Park; Ha-Young Kim; Yun Sang Cho; Seung-Chun Park; Suk-Kyung Lim (Veterinary Research Communications, 2026)

First report of a species of Senga (Cestoda: Bothriocephalidae) in commercial Betta splendens (Actinopterygii: Osphronemidae) in Brazil - Mariana Rodrigues Vale; Ana Clara Fernandes de Moraes; Sarah Portes Carneiro; Felipe Henrique Teixeira da Mata; Jordana Costa Alves de Assis; Henrique César Pereira Figueiredo; Matheus Anchieta Ramirez; Hudson Alves Pinto; Guilherme Campos Tavares (Veterinary Research Communications, 2026)
Species of the genus Senga comprise a group of bothriocephalidean cestodes that predominantly parasitize freshwater teleost fishes, causing severe histopathological alterations due to scolex attachment to the digestive tract or obstruction of the intestinal lumen. The Siamese fighting fish Betta splendens is the type-host of Senga besnardi , the type species of the genus known only from the original description. Despite the importance of this fish species to ornamental aquaculture in Brazil, there are no prior records of this parasite in the Americas. Therefore, the present study aims to report the finding of B. splendens naturally infected with a bothriocephalidean cestode in a commercial fish farm from Brazil. In July 2024, four specimens of B. splendens exhibiting distension of the coelomic cavity were collected from an ornamental fish farm located in Patrocinio do Muriaé, Minas Gerais State. The animals were euthanized and submitted to parasitological analysis. Cestodes found in the fish were fixed, stained, and mounted for study by optical microscopy, with the aim of taxonomic identification. Cestodes were observed in the intestine of 3 out of 4 evaluated B. splendens , with infection intensities of 1, 8 and 10 cestodes per host. Morphological and morphometric analyses revealed that these specimens are indistinguishable from S. besnardi , particularly in the scolex morphology. However, given the complex taxonomy and the lack of molecular data for the species, the cestodes reported here are tentatively identified as Senga sp. This study represents the first report of Senga sp. infecting ornamental fish in the American continent.

Intraspecific interactions simulation in Elm Woodlands using a hybrid ABM-SD model - Guo Li; Yi Tang (Theoretical Ecology, 2026)

Oxidation-Dependent Behavior of Saturated and Unsaturated Phosphatidylcholine Model Membranes: Insights from Langmuir Monolayers and TBARS Analysis - Hoda Talo; Thad Harroun (The Journal of Membrane Biology, 2026)

Is the Bilayer Insertion of the Peptide KALP23 Under Kinetic or Thermodynamic Control? - Alexander Kyrychenko; Alexey S. Ladokhin (The Journal of Membrane Biology, 2026)

From fisher’s perceptions to fisheries governance: A synthesis of local ecological knowledge in the context of overexploitation - Priyanka Swami; J. M. Jeni; Ravindra Pawar (Reviews in Fish Biology and Fisheries, 2026)

PPIB interacts with MET to activate the PI3K-AKT pathway and promote head and neck squamous cell carcinoma pathogenesis - Zhaobo Liu; Lin Wang; Jin Tang; Jingxuan Ran; Linsheng Dong; Yadong Li (Molecular Biology Reports, 2026)

Genomic characterization of an unusual bloodstream Weissella viridescens isolate obtained from a Bulgarian intensive care unit patient - Slavil Peykov; Alexander Stratev; Lyudmila Boyanova; Raina Gergova; Tanya Strateva (Molecular Biology Reports, 2026)

Morin attenuates vancomycin-induced nephrotoxicity via Nrf-2/HO-1, SIRT1/PGC1α and AKT/FOXO1A pathways - Samet Tekin; Merve Bolat; Burak Batuhan Laçin; Tuba Karaarslan; İsmail Bolat; Furkan Aykurt; Burak Çinar; Mohamad Warda; Ali Çinar (Molecular Biology Reports, 2026)

Biochemical and cellular effects of propolis and silver nanoparticle combination: apoptotic signaling and antibiofilm activity - Esra Erdoğan; Berna Özdem; Özge Öztürk Çimentepe; Ibrahim Tekedereli; Işıl Yıldırım (Molecular Biology Reports, 2026)

Potential of intranasal caffeine as a delivery route for treating glutamate-linked hippocampal neurodegeneration by activating endogenous antioxidant defenses - Olia Hamzeh; Fereshteh Pourabdolhossein; Farideh Feizi; Zohre Esmaeili; Farzane Shanehbandpour-Tabari; Mahnaz Baghershiroodi; Roghayeh Pourbagher; Sahar Rostami-Mansoor; Hossein Najafzadehvarzi (Molecular Biology Reports, 2026)

The V577S mutation in the S2 subunit of QX-type IBV attenuates viral adaptation to chicken oviduct epithelial cells and pathogenicity in laying hens - Haili Zhang; Yamei Huang; Shuyun Li; Yuxi Shen; Jing Xia; Yong Huang (Molecular Biology Reports, 2026)

Immunometabolic Effects of SGLT2 Inhibitors on the Th17/Treg Axis: Mechanisms, Evidence, and Implications for Therapeutic Repurposing - Hamza Alasbily; Fathi M. Sherif (Molecular Biology Reports, 2026)

Coordinated suppression of lectin complement pathway effectors and upregulation of SERPING1 defines a thrombo-inflammatory regulatory signature in Acute Coronary disease - Managalli G. Manohara; Veena Nanjappa; Devaraju Chandagal Javaregowda; M. Manjunath; Suttur S. Malini (Molecular Biology Reports, 2026)

Integrated bulk, single-cell and spatial transcriptomic analyses identify KIFC1 as a driver of malignant progression in lung adenocarcinoma - Linghan Tian; Yuanbiao Wang; Li Huang; Yuanyuan Meng; Wei Wu; Yu Cao; Zhenhua Ji; Zihan Wang; Jia Li; Xin Liu (Molecular Biology Reports, 2026)

Programmed cell death in adenomyosis: mechanisms and future perspectives - Islam Ahmed Abdelmawgood; Michael Ibrahim Boushra (Molecular Biology Reports, 2026)

The regulatory network of Mfsd2a in cerebral ischemia: a novel time-targeted intervention framework - Zhidong He; Li Zhang; Jing Sun (Molecular Biology Reports, 2026)

Whole exome sequencing identifies three novel variants and establishes the molecular diagnosis of ATP6V0A4-related distal renal tubular acidosis in a lebanese infant - Tatiana Hachem; Pauline Abou Jaoude; Nabiha Salem; Alain Chebly (Molecular Biology Reports, 2026)

SMS1 and SMS2 differentially regulate platinum chemotherapy sensitivity in ovarian cancer cells - Yongfa Li; Shenghu Zhang; Min Peng; Junyuan Yang (Molecular Biology Reports, 2026)

Enhanced decellularization of human amniotic membrane: optimizing dna clearance and protein retention for clinical applications - Damla Aykora; Gülfem Erbil; Özden Yülek; Fatma Beyazıt; Muhammad Umar Jajere; Cemre Aydeğer; Metehan Uzun (Molecular Biology Reports, 2026)

R-loops in colorectal cancer: mechanisms, mapping strategies, and therapeutic opportunities - Zongyou Huang; Liu Xiang; Donge Tang; Yong Dai (Molecular Biology Reports, 2026)

Tau dysfunction in alzheimer’s disease: molecular and cellular mechanisms, genetic modulation, and therapeutic perspectives - Sreenivasulu Sura; Saravanan Jagadeesan; Mohamad Aris Mohd Moklas; Siti Saleha Masrudin; Krishna Chaitanya Reddy Dandala; John Paul Judson; Nurul Huda MohdNor (Molecular Biology Reports, 2026)

A de novo NR2F1 c.330 C > A variant in Bosch-Boonstra-Schaaf optic atrophy syndrome presenting with early-onset developmental and epileptic encephalopathy - Sina Babaei; Haneieh Honarmand; Mortaza Bonyadi; Baharak Maddahi; Zakiyeh Ebadi; Mohammad Barzegar (Molecular Biology Reports, 2026)

Development of an isoform-discriminating RT-qPCR assay for transcript-level profiling of human ASAH2 in colorectal cancer cell models - You Shan Ngui; Yi-Wen Huang; Shao-Chi Hung; Shih-Han Huang; Chieh-Ju Wen; Yi-An Chang; Hsing-Chen Wu; Hsiu-Chuan Chan; Mei-Lin Chan; Liang-Yin Ke; Hua-Chen Chan (Molecular Biology Reports, 2026)

Navigating the cancer cell nucleus: lamins at the interface of epigenetic regulation and tumorigenesis - Subhadip Kundu (Molecular Biology Reports, 2026)

Elevated interleukin-33, CD1c+ dendritic cells, and interleukin-17A in peritoneal fluid of patients with endometriosis: a case-control study - Wen Yuan; Jiao Huang; Tao He; Huanni Li; Xianqing Wu (Molecular Biology Reports, 2026)

The NO-cGMP signaling pathway and depression: mechanisms and therapeutic prospects - Wenling Pi; Yuting Sun; Xueling Dai; Qing Huo; Zeping Zuo; Fei Xie; Yaxuan Sun (Molecular Biology Reports, 2026)

Mitogenic potential of endogenous GlcNAc-specific lectins from rat brain cell nuclear membranes - Tamar Macharadze; Rusudan Akhalkatsi (Molecular Biology Reports, 2026)

Concentration-dependent dual effects of bacterial nanocellulose on Staphylococcus aureus virulence and human dermal fibroblast function: implications for wound healing - Hesam Sorori; Kumarss Amini; Farzaneh Hosseini; Pedram Heidari (Molecular Biology Reports, 2026)

Phage and CRISPR based precision antimicrobials: a dual strategy against multidrug-resistant bacteria - Anjaneyulu Musini; Vinod Kumar Yata; Sarad Pawar Naik Bukke; Kalal Akhila; Teetla Shivani; Bayapa Reddy Narapureddy; Chandrashekar Thalluri; Awad Osman Abdalla Mohamed; Mohammed Dhawelbate Mohammed Adam (Molecular Biology Reports, 2026)

Cuproptosis in hepatocellular carcinoma: bridging copper homeostasis with therapeutic horizons - Songsong Fan; Aoqing Wang; Rui Peng; Jun Cao; Daoyuan Tu; Bingbing Su; Jiahao Zhang; Shengjie Jin; Guoqing Jiang; Chi Zhang; Dou-Sheng Bai (Molecular Biology Reports, 2026)

Unravelling the phytochemical complexity of neuroprotective plants: a metabolomics approach to Alzheimer’s disease - Shubatra Nahenthara Raj; Maya Erna Natnan; Wong Pei Lou; Ahmed Mediani; Tewin Tencomnao; Syarul Nataqain Baharum (Molecular Biology Reports, 2026)

MicroRNAs in dilated cardiomyopathy: from biomarkers to therapeutic targets - Abisha Vince Jeo V S; P. S. Sneha Sandra; Mahesh Mundalil Vasu; Jeemon Panniyammakal; Sanjay Ganapathi; Madhusoodanan Urulangodi; Neethu Mohan; P. R. Anil Kumar; Srikant Ambatipudi; Jyothi Vijay; Sivadasanpillai Harikrishnan (Molecular Biology Reports, 2026)

Ferroptosis, DNA damage repair, and transporter proteins: associated with platinum sensitivity and prognosis in epithelial ovarian cancer - Mai Gao; Xuan Feng Wang; Qian Long; Dan Yang; Hong Zhu; Jun Zhu (Molecular Biology Reports, 2026)

Dnmt3a-mediated abnormal DNA methylation is associated with myelination deficits in offspring of advanced maternal age rats - Chunxue Jiang; Xinru Yan; Man Xu; Li Cheng; Li Jiang; Wei Han (Molecular Biology Reports, 2026)

Uncovering genetic markers for growth and fat-tail traits in Kurdi sheep: associations with DGAT1 and PPARGC1B variants - Fatemeh Rayeji-Yanesari; Mojtaba Najafi; Saeed Hassani (Molecular Biology Reports, 2026)

Targeting the lncRNA PVT-1-Hippo signaling axis in kidney diseases: an emerging therapeutic paradigm - Hrushikesh Vikas Kulkarni; Anil Bhanudas Gaikwad (Molecular Biology Reports, 2026)

Induced pluripotent stem cell–derived macrophages (iMacs) in translational medicine: Disease models, drug testing, and therapeutic applications - Tara Nur Amalina; Haydar Alsagaff; Sabrina Lazimmatus Sofa; Shofiyah Shofiyah; Bunga Fadhilah Sunaryo; Keila Lova; Achmad Zakky; Hernawan Febrianto; Rizal Azis (Molecular Biology Reports, 2026)

Comparative genomic analysis of oxytocin and oxytocin receptor genes in the family Equidae - Leona Vychodilova; Eva Janova; Martin Plasil; Jan Futas; Karla Stejskalova; Jan Oppelt; Petr Horin (Molecular Biology Reports, 2026)

Non-Drug therapeutic strategies to combat antimicrobial resistance in livestock: a review - Dejen Asaye Mengistu; Yesuneh Tefera Mekasha; Fentahun Wondmnew Molla (Molecular Biology Reports, 2026)

DBF4B promotes hepatocellular carcinoma progression by regulating CCNA2 and PSMD11 expression - Bing Dong; Pengju Xi; Guangxin Yang; Zhiqi Jiao; Shijie Xu; Lin Han; Zhenming Gao (Molecular Biology Reports, 2026)

Pediatric cystic fibrosis is associated with type 3 immune response - Tuğba Nur Gür; Zehra Buşra Azizoğlu; Yesim Haliloğlu; Fatma Zehra Okuş; Şerife Erdem; Melih Hangül; Mehmet Köse; Ahmet Eken; Halit Canatan (Molecular Biology Reports, 2026)

Single-cell profiling reveals IFI44L as a central regulator of immune dysregulation in high HIV viral load - Jiamin Gao; Yanjun Li; Jinping Huang; Xianzhen Huang; Qingdong Zhu; Cailing Wei; Jieling Chen; Shunda Luo; Zhouhua Xie (Medical Microbiology and Immunology, 2026)

Epstein–Barr virus serological profiles and atypical patterns in a large tertiary-care cohort: a retrospective study of 11,503 patients - Sevim Gayenur Buyukberber; Esra Sert; Alparslan Toyran; Bedia Dinc (Medical Microbiology and Immunology, 2026)

Kinetics and characterization of extracellular vesicle release from cells infected with a clinical isolate of respiratory syncytial virus A (ON1 genotype) - Matteo Fracella; Valeria Manganelli; Alessandra Pierangeli; Carolina Scagnolari; Manuel Pacchiele; Eleonora Coratti; Roberta Campagna; Gloria Riitano; Federica Fratini; Agostina Longo; Maurizio Sorice; Guido Antonelli (Medical Microbiology and Immunology, 2026)
Despite the recent approval of preventive measures, the disease burden of respiratory syncytial virus (RSV) infection in children and older adults remains significant. To improve understanding of RSV disease, this study characterized extracellular microvesicles (EMVs) secreted during in vitro infection with a clinical RSV-A (ON1 genotype) strain (RSV/40G-A), isolated in 2022 from a pediatric pneumonia case. The type and content of EMVs released by A549 and BEAS-2B respiratory epithelial cells infected with this clinical isolate were analyzed up to 96 h post-infection (hpi). RSV infection induced a time-dependent increase in EMV levels compared to uninfected controls. EMVs released by infected BEAS-2B and A549 cells contained increasing levels of RSV nucleocapsid protein (RSV-NP) and viral RNA with a peak at 72 hpi. These findings suggest that the kinetics of vesicular release and EMV content are modulated during RSV infection. EMV secretion by host cells may constitute a potential mechanism for intercellular communication or immune activation.

ZDHHC5 may regulate the function of NKT cells and the immune response in Meniere’s disease - Ruilong Li; Keguang Chen (Mammalian Genome, 2026)
Meniere’s disease (MD) is a heterogeneous, rare inner ear disorder characterized by recurrent vertigo, fluctuating sensorineural hearing loss, tinnitus, and aural fullness. Its molecular mechanisms remain unclear due to significant clinical and immunological heterogeneity. In this study, we integrated multi‑omics genetic data to systematically screen for palmitoylation regulatory genes associated with MD risk. We first intersected 31 core palmitoylation genes with blood cis‑eQTL datasets to identify candidate expression‑related genes, then performed two‑sample Mendelian randomization (MR) to examine their genetic correlation with MD. Summary‑data‑based MR (SMR) using two independent peripheral blood eQTL cohorts (eQTLGen and GTEx) was further applied to validate robust candidate genes. Two‑sample inverse‑variance weighted (IVW) MR revealed nominally significant associations between PPT2, ZDHHC18, ZDHHC5 and MD risk. Independent SMR validation confirmed that peripheral ZDHHC5 expression was significantly correlated with MD (eQTLGen: PSMR = 0.023; GTEx: PSMR = 0.006), and a non‑significant HEIDI test ruled out strong linkage disequilibrium confounding. We further explored potential immune mediators using a two‑step MR screening framework covering 731 peripheral immune cell phenotypes. After Benjamini–Hochberg false discovery rate (FDR) correction for all immune traits to control for multiple testing, no immune cell phenotype retained an FDR

Astrocytes orchestrate neuroprotection and pathogenesis via bidirectional neuronal interactions in Parkinson’s disease - Yifan Li; Qiang Li; Yemin Wang; Xuejing Wang; Guangfu Di; Meng Niu; Zhiliang Xu; Yanjiao Huang (Journal of Physiology and Biochemistry, 2026)

The LKB1-AMPK pathway in NAFLD: molecular mechanisms and therapeutic implications - Pouya Goleij; Mohammad Amin Khazeei Tabari; Yousef Naser; Rayan Alataa; Mohammed Ali Mohammed Osman; Aryan Rezaee; Michael Aschner; Ahmed Rabie Dahab Ahmed; Moaad Abou Safrah; Haroon Khan (Journal of Physiology and Biochemistry, 2026)

Label-free proteomic profiling identifies ECM-related alterations across regeneration states in human peripheral axonal neuropathies - Marina Damato; Soulaimane Aboulouard; Velia La Pesa; Francesco Gentile; Giulia Lunghi; Michela Perrone; Beatrice Pranzo; Elena Chiricozzi; Nilo Riva; Isabelle Fournier; Alessandro Romano; Angelo Quattrini; et al. (Journal of Physiology and Biochemistry, 2026)
Understanding the multiple mechanisms underlying peripheral nerve regeneration in humans is crucial for developing effective therapies for peripheral axonal neuropathies. Although i n vitro and in vivo studies have provided significant insights, human studies exploring the composition of proteome remain limited. The ECM plays a crucial role in nerve regeneration, influencing cell adhesion, proliferation, migration, and finally differentiation. In this study, we used a high-sensitivity, label-free liquid chromatography-mass spectrometry (LC-MS) method to investigate the global proteomic profile of human sural nerves aiming to identify molecular dynamics that promote or hinder nerve regeneration in well-characterized cohorts of patients with acute axonal injury, regenerating axonal neuropathy, and non-regenerating axonal neuropathy. Overall, 149 proteins were identified, of which 68 showed significant modulation across the groups. Proteins over-represented in regenerating nerves highlighted the multifactorial nature of regeneration, including immune modulation, debris clearance, cytoskeletal reorganization, axonal extension, and lipid transport. Conversely, structural myelin and neuronal proteins were significantly downregulated in non-regenerating nerves. Among the differentially expressed proteins, functional enrichment analysis revealed a significant overrepresentation of ECM-related components, providing compelling evidence that the ECM is not merely a passive scaffold, but an active driver of peripheral nerve regeneration.

Food Deprivation as a Catalyst for Cannibalistic and Predatory Behavior in Parthenium Beetle, Zygogramma bicolorata - Anthati Vaishnavi; Muzafar Riyaz; Kamlesh Bali; Rakesh Kumar Gupta (Journal of Insect Behavior, 2026)

Age-Related Behavioral Changes Across the Adult Lifespan of a Cricket: A Longitudinal Analysis Using DeepLabCut - Shota Hayakawa; Tomohiro Aihara; Kohyoh Murata; Masanobu Yamamoto; Kosuke Kataoka; Takeshi Suzuki; Toru Asahi (Journal of Insect Behavior, 2026)

Interpretable Spatiotemporal Pattern Mining of Forest-Loss Dynamics - Emna Klai; Ahmed Toujani; Wahbi Jaouadi; Imed Riadh Farah (Journal of Geovisualization and Spatial Analysis, 2026)

Clinical and zebrafish studies of truncating SF3B2-variants in craniofacial microsomia - Dan Xia; Xiaofang Peng; Zihao Deng; Shuyun Deng; Zhanwen He; Jieming Zhang; Xiaoqin Xiao; Xi Sun; Xiao Qian; Xueyuan Zhang; Liyang Liang; Xiaojuan Li (Human Genetics, 2026)

Associations of host gene expression in the brain, liver, muscle with fecal and cecal microbiota composition in pigs - Camila Sabino de Oliveira; Bárbara Silva-Vignato; Simara Larissa Fanalli; Mariah Castro Durval; Felipe André Oliveira Freitas; Andrezza Maria Felício; Lucas Echevarria Nascimento; Fernanda Nery Ciconello; Thiago Sugizaki dos Santos; Luciana Correia de Almeida Regitano; Luiz F. Brito; Aline Silva Mello Cesar (Functional & Integrative Genomics, 2026)
Understanding the genetic regulation underlying host–microbiota interactions is key to elucidating how microbial communities influence host metabolism, immunity, and physiology. In this context, the main objective of this study was to integrate genomic, transcriptomic, and microbial data to identify shared regulatory variants, highlight key microbial taxa, and prioritize biological pathways related to lipid metabolism, immune function, and host metabolic adaptation across multiple tissues in 72 immunocastrated male Large White pigs (S us scrofa ). Expression quantitative trait loci (eQTL)-informed association analyses were performed to link the gut microbiota with host genetics. The analyses included microbial amplicon sequence variants (ASVs, ≥ 10% prevalence) from 16S rRNA sequencing, along with host cis- and trans-eQTL identified in brain, liver, and muscle tissues. Cross-tissue associations were detected between host gene expression and several bacterial genera, particularly Oscillospira , Candidatus Methanoplasma , Roseburia , Anaerostipes , and Monoglobus . A subset of eQTL, cis- and/or trans, showed multiple significant associations and regulated the expression of genes including ZDHHC2 , TMEM69 , and CCDC167 , which have been implicated in lipid metabolism, immune regulation, and energy balance. The brain’s gene expression showed the most significant number of regulatory variants and enriched pathways related to fatty acid metabolism and immune processes, highlighting potential interactions along the gut–brain axis. These findings provide insights into the underlying host–microbiota relationships in pigs. Integrating eQTL and microbiota data across tissues revealed genetically mediated, cross-tissue regulatory networks linking microbial composition to host metabolic and immune functions. This offers a framework for functional validation and multi-omics studies in pigs.

Integrated profiling identifies NCOA3 as a prognostic factor in patients with glioma - Qian Luo; Jiaying Yang; Hailin Yin; Mei Yang; Yueyang Liang; Yixuan Hou; Xinze Sun; Jixuan Liu; Ling Zhang (Functional & Integrative Genomics, 2026)

Integrative multi-omics analysis identifies SMIM24 as a favorable prognostic biomarker in clear cell renal cell carcinoma - Zongyu Li; Yiting Liu; Yaxin Hou; Yuhong Ding; Zhenghao Liu; Yang Li; Pengjie Shi; Yixian Li; Yingchun Kuang; Lijie Zhou; Ke Chen; Lilong Liu (Functional & Integrative Genomics, 2026)

Integrated genomic analysis of Salmonella Typhi from Pakistan: Antimicrobial resistance determinants, pangenome structure, and reverse vaccinology-driven vaccine target discovery - Hamza Arshad Dar; Arslan Saleem Chughtai; Ali Hyder Baig; Kashif Asghar (Functional & Integrative Genomics, 2026)

First practice on bacteriophage-mediated disinfection of tailwater: targeted removal of multidrug-resistant Vibrio parahaemolyticus and associated antibiotic resistance genes - Yanxi Liu; Jian Lu; Jun Wu; Jianhua Wang; Brian J. Boman (ENGINEERING Environment, 2026)

A task-aligned multimodal machine learning framework for studying working memory dysfunction in Parkinson’s disease - Mercedes Terry; Samuel A. Birkholz; Jeffery S. Johnson; Jau-Shin Lou; Asenath X. Heuther; Jessica Keller; Enrique Alvarez Vazquez (Cognitive Neurodynamics, 2026)
Cognitive impairment is one of the most functionally debilitating non-motor symptoms in Parkinson's disease (PD). Yet, current diagnostic and clinical practices rely heavily on subjective assessments and burdensome behavioral testing, which lack the temporal resolution to detect subtle deficits. While EEG and pupillometry offer promising non-invasive insights into cognitive processing, more scalable and objective methods are needed to detect subtle and often elusive dysfunction in early PD. Machine learning (ML) leverages patterns in neurophysiological signals recorded during cognitive tasks to identify subtle impairments that may not be evident in standard evaluations. We recorded EEG and pupillometry data from 68 participants (35 PD, 33 healthy controls (HC)) during a visual Change Detection working memory task. Using our custom, standardized feature-extraction toolbox, we extracted 108 features and incorporated the resulting feature matrices into an ML pipeline. We applied SMOTE to balance the classes, then used principal component analysis (PCA) to reduce dimensionality. An automated elbow method identified optimal cutoffs for principal components (PCs) and original features, which guided subsequent recursive elimination (RE) for computational efficiency. We trained a support vector machine with a radial basis function kernel (SVM-RBF) to classify PD and evaluated the final model's performance on a hold-out dataset. The automated elbow method identified optimal cutoffs at 20 PCs and 22 original features. The RE revealed that a model using 14 PCs and the top 7 PCA-weighted features achieved the highest performance, with 71% accuracy and an F1 score of 0.701. The classifier's performance declined slightly when tested on held-out data, with an accuracy of 63% and an F1 score of 0.626. This study demonstrates the potential of a task-aligned ML pipeline for uncovering early cognitive markers of PD. The framework supports post-hoc feature contribution mapping, linking retained physiological features and task stages back to classification-relevant patterns, supporting mechanistic investigation of cognitive dysfunction in PD.

Dynamic mechanisms underlying neurotransmitter-regulated brain excitation-inhibition balance: insights from the MDMF model - Xinxin Ren; Youyou Si; Honghui Zhang (Cognitive Neurodynamics, 2026)

EFS-NET: EEG-fNIRS multi-scale fusion network based on spatial calibration - Wenhao Gu; Ian Daly; Xinjie He; Shurui Li; Andrew Ty Lau; Xingyu Wang; Andrzej Cichocki; Yong Chen; Jing Jin (Cognitive Neurodynamics, 2026)

Feedback-regulated dual-role memory consolidation for continual learning: a stability–plasticity framework inspired by hippocampo-cortical systems consolidation - Zhaojie Yu; Shengli Cao; Guohe Zhang; Peihua Feng (Cognitive Neurodynamics, 2026)

Assessing collapse dolines susceptibility mapping in the Moroccan Sahel-Doukkala karst using statistical and random forest methods - Mohammed Bouzerda; Khalid Mehdi; Othmane Boualla; Ahmed Fadili; Saliha Najib; Youssef Sadik (Carbonates and Evaporites, 2026)

Karst aquifer vulnerability assessment using the COP and EPIK methods in central Brazil - Ana Karolyna Nunes Amaral; Luis Felipe Soares Cherem; Renata Santos Momoli; Márcio Henrique de Campos Zancopé (Carbonates and Evaporites, 2026)
Karst aquifers are highly susceptible to contamination and the application of methodologies that identify these critical areas is an excellent strategy for promoting their conservation. With this in mind, this study aims to assess the applicability of two aquifer vulnerability classification methods, COP and EPIK, in the Terra Ronca State Park (PETeR) and Serra Geral APA conservation units, located in Central Brazil. The chosen methods assess the physical conditions of the environment (relief, lithology, soils, karst features, vegetation) to determine the areas naturally vulnerable to contamination. The analyses were carried out in a GIS environment. The results for the COP method showed a predominance of areas with low (43.08%) to very low (33.72%) vulnerability, followed by moderate (16.20%), high (5.25%) and very high (1.81%) vulnerability. As for the EPIK method classification, the high (44.52%) and moderate (41.92%) classes predominated, while the other classes, very high and low, accounted for 4.68% and 8.88% respectively. It is important to note that the differences in the proportions of areas in each class in the methods applied can be attributed to the varying weights assigned to the parameters used and the differences in the classification categories. Despite the differences, both methods identified areas with very high vulnerability in the central part of the study area, precisely where karst features such as caves and dolines are concentrated. This highlights the importance of identifying the most vulnerable areas in a karst environment in order to ensure sustainable management of its natural resources.

A systematic study of the phosphate-bearing sedimentary rocks of Tehri Garhwal, Uttarakhand: constraining the paleo-redox conditions - Vikash Kumar; Shamim A. Dar; Nozmul Karim; Mohammad Javed; Sumit K. Ghosh (Carbonates and Evaporites, 2026)

Hydrochemical characteristics of groundwater and formation mechanism of Sr–rich mineral water in the Northern Carbonate Region, Yiyuan - Chen Sheng; Mingguo Wang; Peng Chen; Zitao Wang; Yangyang Min; Sichu Bai; Di Wu; Xianzhang Dang; Tong Li (Carbonates and Evaporites, 2026)

Monitoring and early warning technologies on karst lands: surface collapse and groundwater contamination - Gheorghe M. L. Ponta (Carbonates and Evaporites, 2026)

development and in vitro characterization of a Trichoderma-based biopesticide for the management of Fusarium solani in tomato - Thulfiqear A. Jabbar; Aqeel N. AL-Abedy; AbdulZahra J. Ali (Brazilian Journal of Microbiology, 2026)

Characterization of 2-deoxyribose-5-phosphate aldolase from Bacillus altitudinis JYY-02 - Wentao Feng; Chenglei Qin; Wenjun Deng; Qunqun Guo; Chao Wang; Guicai Du; Ronggui Li (Brazilian Journal of Microbiology, 2026)

An experimental multiplex PCR/RT-PCR for detection of the main viruses associated with equine neurological disease - S. O. de Scherer; J. V. J. Silva Júnior; N. H. Pedroso; I. F. Dionisio; R. Weiblen; E. F. Flores (Brazilian Journal of Microbiology, 2026)
Viral neurological infections are important causes of morbidity and mortality in horses worldwide. Herein, we describe an end-point multiplex PCR/RT-PCR for simultaneous and differential detection of major equine encephalitis-related agents: rabies virus (RABV), equine herpesvirus type 1 (EHV-1), alphaviruses [Venezuelan equine encephalitis virus (VEEV), Eastern equine encephalitis virus (EEEV), Western equine encephalitis virus (WEEV) and Madariaga virus (MADV)] and flaviviruses [West Nile virus (WNV), Saint Louis encephalitis virus (SLEV), Rocio virus (ROCV) and Japanese encephalitis virus (JEV)]. The multiplex assay successfully amplified all targets either individually or simultaneously: alphavirus (381 bp—experimentally evaluated for MADV and potentially applicable to EEEV and WEEV based on primer design and sequence conservation), EHV-1 (255 bp), RABV (173 bp), VEEV (119 bp), and flavivirus (97-101 bp—experimentally evaluated using ROCV, with the potential to also detect WNV, SLEV and JEV, based on primer design and sequence conservation). Furthermore, the assay demonstrated analytical sensitivity and specificity that support its use for the comprehensive etiological diagnosis of equine neurological diseases. Overall, the multiplex PCR/RT-PCR described here may contribute to the diagnosis of viral neurological infections in horses, reducing costs and turnaround time, while contributing to prevention and control measures.

Genomic insights from a long-read assembly of a deep-sea Chromohalobacter israelensis strain from Santos Basin pockmarks field - Ian Ariel Barbosa Nunes; Adan Rodrigues de Oliveira; Adonney Allan de Oliveira Veras; Artur Silva; Elielson Cabral Costa; Flúvio Modolon; Francielli Vilela Peres; Michel Michaelovitch de Mahiques; Rafael Azevedo Baraúna; Sávio de Souza Costa; Diego Assis das Graças; Vivian Helena Pellizari (Brazilian Journal of Microbiology, 2026)
Continental slopes, particularly the pockmark and salt diapir regions of the Santos Basin, represent extreme environments characterized by high hydrostatic pressure, low temperatures, elevated salinity, and limited organic matter, fostering unique bacterial communities. This study aimed to elucidate the metabolic strategies enabling survival in these conditions by exploring the genome of a Chromohalobacter israelensis strain isolated from such sediments, utilizing long-read sequencing. The genome, assembled into a single 3.8 Mb contig with 98.9% completeness, confirmed the strain’s taxonomic identity. Analysis revealed genes for metabolizing diverse carbohydrate sources, a complete ectoine synthesis cluster essential for halophily, and genes conferring tolerance to osmotic stress, low temperatures, and pH, underscoring its polyextremophilic capacity. Pangenome analysis identified a substantial core genome with essential metabolic functions, including a species-exclusive sulfur metabolism reaction. These findings highlight the strain’s biotechnological potential and contribute to understanding the genus’s adaptation to diverse hypersaline habitats and the strain’s potential role in the sampled environment.

Microbial oil production by Yarrowia lipolytica strains using glycerol as carbon source - Elisa Duarte Guerra Coelho; Fernanda Palladino; Elisa A. A. Teixeira; Fernanda L. C. Oliveira; Vânya M. D. Pasa; Luiz H. Rosa; Carlos A. Rosa (Brazilian Journal of Microbiology, 2026)
Yeasts can produce microbial oil from hydrophobic substrates such as glycerol, a byproduct of the biodiesel industry that is often undervalued in the market. Yarrowia lipolytica is capable of degrading glycerol and is considered a model organism for studying lipid accumulation. Different yeast strains and culture conditions can result in varying lipid yields with distinct fatty acid profiles. Thus, in this study, five strains of Y. lipolytica were tested for microbial oil production using pure glycerol at temperatures of 15 °C and 25 °C. None of the isolates were considered oleaginous at 15 °C. However, at 25 °C, the isolates UFMG-CM-Y6114 (from cheese), UFMG-CM-Y4187 (from beach sand), and UFMG-CM-Y6189 (from Antarctica) produced more than 20% lipid content (29.30%, 26.95%, and 34.38%, respectively). No significant differences in lipid content were observed between the UFMG-CM-Y6114 and UFMG-CM-Y4187 strains. The cheese- and Antarctica-derived strains were further tested for their ability to accumulate oil when grown on crude glycerol. Among them, UFMG-CM-Y6189 showed the best performance, producing 9.40 g·L⁻¹ of biomass, 1.90 g·L⁻¹ of lipid yield, and 21.56% lipid content, while consuming 61.3 g·L⁻¹ of glycerol. The fatty acid profile of these lipids was predominantly monounsaturated (59.5%), with oleic acid (49.4%) as the main component. This, combined with a low polyunsaturated fatty acid content (5.2%), makes these lipids particularly suitable for biodiesel production. Therefore, the lipids from the Y. lipolytica strain UFMG-CM-Y6189 represent a promising raw material for biodiesel production from glycerol.

Genetic architecture and functional dynamics of integrons in Staphylococcus aureus resistance - Anjaneyulu Musini; Madeeha Owais; Rerelly Joshika (Brazilian Journal of Microbiology, 2026)

Performance evaluation of methods for detecting enteric viruses in meat products - Lucas Zanchetta; Paula Rogovski; Henrique Borges da Silva Grisard; Beatriz Pereira Savi; Catielen Paula Pavi; Sabrina Carvalho Suominsky; Giulia Von Tönnemann Pilati; Gislaine Fongaro (Brazilian Journal of Microbiology, 2026)
Meat products represent important vehicles for foodborne viral transmission, yet standardized detection methodologies for these complex matrices remain limited. This study systematically compared three viral recovery methods across nine meat products representing chicken, pork, and processed deli meat matrices: polyethylene glycol 6000 (PEG) precipitation, glycine buffer-chloroform (GBC) phase separation, and β-mercaptoethanol (B-M) chaotropic lysis. Using Murine Norovirus 1 (MNV-1) and Murine Hepatitis Virus 3 (MHV-3) as process controls, recovery efficiency was assessed by RT-qPCR. The B-M method demonstrated the most consistent performance, successfully detecting MNV-1 across all tested matrices and significantly outperforming PEG and GBC for MNV-1 in chicken and pork. Applying the B-M method to 25 commercial retail products revealed the genetic material of Hepatitis E virus (HEV) in four samples and Porcine Circovirus type 2 (PCV-2) in one sample, exclusively within pork products. These findings provide critical comparative performance data for method selection in viral surveillance of meat and document the occurrence of HEV and PCV-2 genetic material in commercial pork products from Santa Catarina, Brazil, highlighting a significant food and agricultural biosafety concern in this major meat-producing and exporting state.

Integrated multi-omics strategy for screening novel protective antigens against Brucella melitensis and analysis of their immunogenicity - Zhiheng Dong; Sha Li; Jiarong Guo; Lidao Bao (Brazilian Journal of Microbiology, 2026)
Background Brucellosis is one of the most severe Class B infectious diseases prevalent in the agricultural and pastoral areas of northern China. Current attenuated live vaccines (e.g., M5, S19) have defects such as residual virulence, causing abortion in pregnant animals, and the inability to differentiate between natural infection and vaccination (DIVA). Methods Relying on the ABSL-3 laboratory of the Inner Mongolia Center for Disease Control and Prevention, this study established a chronic infection model in C57BL/6J mice using the virulent strain Brucella melitensis M16. Single-cell transcriptome sequencing (10x Genomics) was employed to map the heterogeneity of splenic immune cells. Whole-genome scanning and pangenomic analysis were performed on four strains with different virulence levels (M16, 544 A, M5, 104 M) using second-generation sequencing. Membrane/secreted proteins unique and conserved in virulent strains were screened as candidate antigens, prepared via prokaryotic expression systems, and their humoral and cellular immune levels were detected by indirect ELISA and flow cytometry. Results A stable chronic infection model was successfully constructed (bacterial load Log10 CFU > 4.5). Single-cell sequencing yielded 45,231 cells, annotated into 12 immune cell subpopulations, revealing significant expansion of Effector CD4 + T cells ( P Ifng gene. Pangenomic analysis identified three candidate antigens (BMEI0021, BMEI1943, BMEI0367) that are 100% conserved in virulent strains but absent in the vaccine strain M5. Immunogenicity assays showed that BMEI1943 induced high levels of IgG2a subtype antibodies (titer Log2 13.45 ± 0.52) and IFN-γ + CD4 + T cell responses (frequency 15.80% ± 2.10%). Conclusion Through multi-omics integration analysis, this study successfully identified a novel candidate antigen, BMEI1943, with strong Th1-type immunogenicity, providing an experimental basis for the development of safe and efficient subunit vaccines against brucellosis.

Biotechnological potential of Paenarthrobacter nicotinovorans ATCC 49919 for the microbial conversion of nicotine and tobacco extracts into 6-hydroxynicotine - Iustin-Tiberius Munteanu; Ana Huşleag; Robert Iustin Susanu; Andreea-Mihaela Mleşniță; Marius Mihăşan (Brazilian Journal of Microbiology, 2026)
Nicotine-rich wastes from the tobacco industry represent an environmental liability but also a potential feedstock for value-added bioconversion. In this study, the biotechnological potential of Paenarthrobacter nicotinovorans ATCC 49919 for selective accumulation of 6-hydroxy-(L)-nicotine (6HLN), the first intermediate of the pyridine pathway, was evaluated under flask and bioreactor conditions. Two metabolic engineering strategies were explored: transcriptional silencing of the 6-hydroxynicotine oxidase gene ( 6hlnO ) using a CRISPR/dCas9 system and overexpression of the nicotine dehydrogenase large subunit ( ndhL ) to enhance entry flux into the pathway. Among the tested strains, the ndhL -overexpressing derivative exhibited the highest 6HLN accumulation during growth (up to 1.78 g L⁻ 1 ; space–time yield 104.4 mg L⁻ 1 h⁻ 1 ). Resting-cell bioconversion experiments identified 100 g wet cell weight L⁻ 1 as an optimal biomass loading. Chemical inhibition of 6-hydroxy-L-nicotine oxidase with 0.8 mM ZnSO 4 further expanded the 6HLN accumulation window without substantially impairing nicotine depletion. Scale-up experiments in a stirred bioreactor demonstrated effective conversion of both pure nicotine and tobacco-derived extracts, with matrix-dependent differences in conversion kinetics. Dissolved oxygen profiles correlated reproducibly with substrate depletion and product turnover, providing a potential online process control signature. Although not achieving near-stoichiometric yields reported for knockout-based systems, the described platform offers a controllable and feedstock-flexible approach for nicotine waste valorization.

Morphological and phylogenetic analyses of Gonatobotryum (Dothideaceae, Dothideales), and the description of a new species from a mangrove sediment in Brazil - Karen B. E. Carmo; Thiago G. Carvalho; Camila S. Oliveira; Esmael A. Vital; Gabriel G. Barreto; Luis F. P. Gusmão; Melissa F. Landell; Pedro H. Félix-Oliveira; Cristina M. Souza-Motta; Layanne O. Ferro; Jadson D. P. Bezerra (Brazilian Journal of Microbiology, 2026)
Gonatobotryum is an anamorphic fungus reported mainly as a saprophyte, parasite, or endophyte. The genus has traditionally been identified based on morphological features, with its phylogenetic placement remaining uncertain due to the lack of molecular data. During the analysis of fungi obtained from mangrove sediments in Brazil, nine isolates were morphologically identified as Gonatobotryum and subsequently analysed using the internal transcribed spacer (ITS) region, including the intervening 5.8S nRNA gene and the nuclear ribosomal RNA large subunit (LSU) gene, leading to the description of a new species, Gonatobotryum mangrovei . Additionally, the type material of Gonatobotryum bahiense was re-evaluated regarding its phylogenetic placement. Here, we propose a new combination, Ophiostoma bahiense , to place this species within the genus. Our results clarify the phylogenetic position of Gonatobotryum and expand the current understanding of fungi in mangrove environments.

Seasonal dynamics, size distribution profiles, and regional respiratory deposition risks of indoor and outdoor residential bioaerosols in Pune, India - Akshay Kale; P. Gursumeeran Satsangi (Aerobiologia, 2026)

Agricultural management intensity drives niche partitioning of ammonia oxidizers at three contrasting soil sites - Yu Zeng; Che Tan; Chang Yin; Xiaozhong Wang; Hongsheng Gao; Hua Peng; Yongchao Liang (Applied Soil Ecology, 2026)