Prenatal perfluoroalkyl substances exposure and neurodevelopment in toddlers: Findings from SMBCS - Boya Zhang; Zheng Wang; Jiming Zhang; Yiming Dai; Chao Feng; Yuanjie Lin; Lei Zhang; Jianqiu Guo; Xiaojuan Qi; Xiuli Chang; Dasheng Lu; Chunhua Wu; et al. (Chemosphere, 2023)

Chlorpyrifos induces neuronal cell death via both oxidative stress and Akt activation downstream-regulated CHOP-triggered apoptotic pathways - Jhe-Wei Lin; Shih-Chang Fu; Jui-Ming Liu; Shing-Hwa Liu; Kuan-I Lee; Kai-Min Fang; Ren-Jun Hsu; Chun-Fa Huang; Kun-Min Liu; Kai-Chih Chang; Chin-Chuan Su; Ya-Wen Chen (Toxicology in Vitro, 2023)

Ambient relative humidity-dependent obstructive sleep apnea severity in cold season: A case-control study - Kuan-Jen Bai; Wen-Te Liu; Yuan-Chien Lin; Yansu He; Yueh-Lun Lee; Dean Wu; Ta-Yuan Chang; Li-Te Chang; Chun-Yeh Lai; Cheng-Yu Tsai; Kian Fan Chung; Kin-Fai Ho; et al. (Science of The Total Environment, 2023)

Spatial allocation of LID practices with a water footprint approach - Wen-Kai Chuang; Zih-Ee Lin; Tzu-Chi Lin; Shang-Lien Lo; Chia-Lin Chang; Pei-Te Chiueh (Science of The Total Environment, 2023)

InSAR-based investigation on spatiotemporal characteristics of river sediment behavior - Shih-Yuan Lin; Shih-Teng Chang; Ching-Fang Lee (Journal of Hydrology, 2023)

Propagation from meteorological to hydrological drought and its application to drought prediction in the Xijiang River basin, South China - Qingxia Lin; Zhiyong Wu; Yuliang Zhang; Tao Peng; Wenjuan Chang; Jiali Guo (Journal of Hydrology, 2023)

Zoning method of aquatic ecosystem functional management fourth-level region in the Daqing River Basin, China - Lihui Sun; Chang Shu; Lin Ding; Ziqiang Tian; Hao Liu (Journal of Environmental Management, 2023)

Greenhouse gas emission indicators, energy consumption efficiency, and optimal carbon emission allowance allocation of the EU countries in 2030 - Tai-Yu Lin; Yung-Ho Chiu; Yi-Nuo Lin; Tzu-Han Chang; Pei-Yu Lin (Gas Science and Engineering, 2023)

Evaluation of visible spectroscopy and low-field nuclear magnetic resonance techniques for screening the presence of defects in broiler breast fillets - Bin Pang; Brian Bowker; Chang-Hu Xue; Yao-Guang Chang; Jian Zhang; Lin Gao; Hong Zhuang (Food Control, 2023)

Topographic constraints on the distribution of selenium in the supergene environment: A case study at Yutangba, China - Hui Chang; Jian-Ming Zhu; Zhi-Qing Lin; Lei Meng (Environmental Pollution, 2023)

Associations between maternal phthalate exposure and neonatal neurobehaviors: The Taiwan maternal and infant cohort study (TMICS) - Hsing-Kang Chen; Shu-Li Wang; Yu-Hsun Chang; Chien-Wen Sun; Ming-Tsang Wu; Mei-Lien Chen; Yu-Jie Lin; Chia-Jung Hsieh (Environmental Pollution, 2023)

Possible influence of typhoons, volcanic ash, and ocean productivity on early larval survival and Japanese eel annual cohort recruitment - Yu-Lin K. Chang; Michael J. Miller (Deep Sea Research Part I: Oceanographic Research Papers, 2023)

In situ derived sulfated/sulfonated carbon nanogels with multi-protective effects against influenza a virus - Hung-Yun Lin; Ka-Long Luo; Ju-Yi Mao; Chin-Jung Lin; Chen-Yow Wang; Lauren Panny; Shiow-Yi Chen; Shih-Chao Lin; Chih-Ching Huang; Scott G. Harroun; Robert Y.L. Wang; Chang-Jer Wu (Chemical Engineering Journal, 2023)

Fabrication of noble-metal-free hierarchical rectangular tubular S-scheme NiS/ZnIn2S4/AgIn(WO4)2 nanocomposite for highly efficient photocatalytic hydrogen evolution - Huihui Zhang; Huajun Gu; Xinglin Wang; Shengyuan Chang; Qin Li; Wei-Lin Dai (Chemical Engineering Journal, 2023)

Hydrodynamics and mass transfer performance of gas–liquid microflow in viscous liquids - Lin Sheng; Yu Chang; Jian Deng; Guangsheng Luo (Chemical Engineering Journal, 2023)

Antifungal mechanisms of polymeric quaternary ammonium salts against conidia of Fusarium oxysporum f. sp. cubense, race 4 - Wei Zhang; Yaoyao Chang; Weiqiang Zhong; Anqiang Zhang; Yaling Lin (European Journal of Plant Pathology, 2023)

Automatic diagnosis of late-life depression by 3D convolutional neural networks and cross-sample Entropy analysis from resting-state fMRI - Chemin Lin; Shwu-Hua Lee; Chih-Mao Huang; Guan-Yen Chen; Wei Chang; Ho-Ling Liu; Shu-Hang Ng; Tatia Mei-Chun Lee; Shun-Chi Wu (Brain Imaging and Behavior, 2023)
Resting-state fMRI has been widely used in investigating the pathophysiology of late-life depression (LLD). Unlike the conventional linear approach, cross-sample entropy (CSE) analysis shows the nonlinear property in fMRI signals between brain regions. Moreover, recent advances in deep learning, such as convolutional neural networks (CNNs), provide a timely application for understanding LLD. Accurate and prompt diagnosis is essential in LLD; hence, this study aimed to combine CNN and CSE analysis to discriminate LLD patients and non-depressed comparison older adults based on brain resting-state fMRI signals. Seventy-seven older adults, including 49 patients and 28 comparison older adults, were included for fMRI scans. Three-dimensional CSEs with volumes corresponding to 90 seed regions of interest of each participant were developed and fed into models for disease classification and depression severity prediction. We obtained a diagnostic accuracy > 85% in the superior frontal gyrus (left dorsolateral and right orbital parts), left insula, and right middle occipital gyrus. With a mean root-mean-square error (RMSE) of 2.41, three separate models were required to predict depressive symptoms in the severe, moderate, and mild depression groups. The CSE volumes in the left inferior parietal lobule, left parahippocampal gyrus, and left postcentral gyrus performed best in each respective model. Combined complexity analysis and deep learning algorithms can classify patients with LLD from comparison older adults and predict symptom severity based on fMRI data. Such application can be utilized in precision medicine for disease detection and symptom monitoring in LLD.

Antiherbivore effect of Cuscuta campestris against Spodoptera frugiperda - Chang-Lin Sung; Fang-Yu Hu; Yi Li; Shin-Fu Tsai; Wen-Po Chuang (Arthropod-Plant Interactions, 2023)

Intraoperative Detection of Surgical Gauze Using Deep Convolutional Neural Network - Shuo-Lun Lai; Chi-Sheng Chen; Been-Ren Lin; Ruey-Feng Chang (Annals of Biomedical Engineering, 2023)

Editorial: Oceanographic processes linking nearshore, continental shelf, and shelf break - Feng-Hsun Chang; Yun-Chi Lin; Kuo-Ping Chiang; Ya-Han Nien; Chih-hao Hsieh; Wei-Jen Chen; Chin-Chang Hung; Toru Kobari; Hiroaki Saito; William Savidge (Frontiers in Marine Science, 2023)

The construction of high efficient visible-light-driven 3D porous g-C3N4/Fe3O4 photocatalyst: A new photo-induced bacterial inactivation material enhanced by cascade photo-Fenton reaction - Ze-Yu Liu; Wen-Qian Huang; Chuan-Qing Huang; Zhao-Zhen Liu; Xiao-Yue Tang; Wei-Chang Chen; Zheng-Zheng Tang; Yu-Xing Huang; Shuo-Chun Zheng; Lin Lin; Changzhu Li; Yong Ye (Chemosphere, 2023)

Do ectoparasites on fish gills “talk” with gut microbiota far away? - Lin Wang; Defeng Zhang; Jun Xie; Ouqin Chang; Qing Wang; Cunbin Shi; Fei Zhao; Hua Gong; Yan Ren; Najiah Musa; Kok Leong Lee; Houjun Pan (Aquaculture, 2023)

Perfluoroalkyl acids in the aquatic environment of a fluorine industry-impacted region: Spatiotemporal distribution, partition behavior, source, and risk assessment - Zu-lin Hua; Chang Gao; Jian-yun Zhang; Xiao-qing Li (Science of The Total Environment, 2023)

Is e-waste a source of phthalate and novel non-phthalate plasticizers? A comparison study on indoor dust - Zongrui Li; Chang He; Jing Yang; Tianrui Gao; Yichao Huang; Lin Tao (Science of The Total Environment, 2023)

Identification of high-concern organic pollutants in tap waters from the Yangtze River in China based on combined screening strategies - Liben Chou; Chengzhuo Zhou; Wenrui Luo; Jing Guo; Yanhong Shen; Die Lin; Chang Wang; Hongxia Yu; Xiaowei Zhang; Si Wei; Wei Shi (Science of The Total Environment, 2023)

Infusing satellite data into aerosol forecast for near real-time episode detection and diagnosis in East Asia - Sheng-Po Chen; Cheng-Hsuan (Sarah) Lu; James E. Davies; Chang-Feng Ou-Yang; Neng-Huei Lin; Amy K. Huff; Bradley R. Pierce; Shobha Kondragunta; Jia-Lin Wang (Science of The Total Environment, 2023)

Corrigendum to “Comparative efficacy of omega-3 polyunsaturated fatty acids on major cardiovascular events: A network meta-analysis of randomized controlled trials” [Progress in Lipid Research. 2022 Oct 28;88:101196. doi: 10.1016/j.plipres.2022.101196] - Bo Yang; Ping-Tao Tseng; Xiang Hu; Bing-Yan Zeng; Jane Pei-Chen Chang; Yang Liu; Wei-Jie Chu; Shuang-Shuang Zhang; Zhi-Liang Zhou; Chih-Sheng Chu; Cheng-Ho Chang; Yu-Kang Tu; et al. (Progress in Lipid Research, 2023)

Microbiome reengineering by four environmental factors for the rapid biodegradation of trichloroethylene - Yu-Hsuan Cheng; Shu-Chi Chang; Yan-Lin Lai; Chung-Chi Hu (Journal of Environmental Management, 2023)

Absorption behavior of polycarboxylate superplasticizer with different molecular structures on montmorillonite - Haifeng Yang; Mingyi Li; Lisha Pan; Ping Zhang; Rami Adel Pashameah; Hala M. Abo-Dief; Shuying Xu; Chang Lin; Hassan Algadi; Jiacheng Li; Qinglong Jiang; Zhanhu Guo (Environmental Research, 2023)

Using cluster algorithms with a machine learning technique and PMF models to quantify local-specific origins of PM2.5 and associated metals in Taiwan - Chin-Yu Hsu; Jhy-Charm Soo; Sheng-Lun Lin; Chih-Da Wu; Kai Hsien Chi; Wen-Chang Hsu; Chun-Chieh Tseng; Yu-Cheng Chen (Environmental Pollution, 2023)

Realizing the bifunctional electrocatalysis via local charge rearrangement of α-CrOOH-modulated Co@CoMoOx for overall water splitting - Suh-Ciuan Lim; Chao-Lung Chiang; Chun-Kuo Peng; Wen-Bin Wu; Yu-Chang Lin; Yu-Ru Lin; Chi-Liang Chen; Yan-Gu Lin (Chemical Engineering Journal, 2023)

High-efficiency control of pesticide and heavy metal combined pollution in paddy soil using biochar/g-C3N4 photoresponsive soil remediation agent - Hantong Qie; Meng Ren; Chang You; Xuedan Cui; Xiao Tan; Yuting Ning; Meng Liu; Daibing Hou; Aijun Lin; Jun Cui (Chemical Engineering Journal, 2023)

Lightweight Flexible Polyimide-Derived Laser-Induced Graphenes for High-Performance Thermal Management Applications - Yu-Sheng Hsiao; Cai-Wan Chang-Jian; Tzu-Yen Huang; Ying-Lin Chen; Chung-Wei Huang; Jen-Hsien Huang; Nian-Jheng Wu; Shih-Chieh Hsu; Chih-Ping Chen (Chemical Engineering Journal, 2023)

Functionalized graphene oxide/sodium alginate beads with ion responsiveness for uranium trapping - Yu Nan; Jianli Wang; Xue Chang; Kejin Shao; Yuchen Lin; Lijuan Qian; Zhan Li; Peizhuo Hu (Carbohydrate Polymers, 2023)

Physiological equivalent temperature-based and universal thermal climate index-based adaptive-rational outdoor thermal comfort models - Sheng Zhang; Xia Zhang; Dun Niu; Zhaosong Fang; Han Chang; Zhang Lin (Building and Environment, 2023)

CFD simulations of effects of recirculation mode and fresh air mode on vehicle cabin indoor air quality - Tong-Bou Chang; Yu-Sheng Lin; Yi-Tian Hsu (Atmospheric Environment, 2023)

Andrographolide ameliorates hepatic steatosis by suppressing FATP2-mediated fatty acid uptake in mice with nonalcoholic fatty liver disease - Li-Sha Ran; Ya-Zeng Wu; Yi-Wen Gan; Hong-Lian Wang; Li-Juan Wu; Chun-Mei Zheng; Yao Ming; Ran Xiong; Yong-Lin Li; Shi-Hang Lei; Xue Wang; Xiao-Qing Lao; et al. (Journal of Natural Medicines, 2023)
Excessive intrahepatocellular lipid accumulation or steatosis is caused by abnormal lipid metabolism and a common character of nonalcoholic fatty liver disease (NAFLD), which may progress into cirrhosis and hepatocellular cancer. Andrographolide (Andro) is the primary active ingredient extracted from Andrographis paniculata , showing a protective role against dietary steatosis with the mechanism not fully understood. In this study, we showed that administration of Andro (50, 100, and 200 mg/kg/day for 8 weeks, respectively) attenuated obesity and metabolic syndrome in high-fat diet (HFD)-fed mice with improved glucose tolerance, insulin sensitivity, and reduced hyperinsulinemia, hyperglycemia, and hyperlipidemia. HFD-fed mice presented hepatic steatosis, which was significantly prevented by Andro. In vitro, Andro decreased the intracellular lipid droplets in oleic acid-treated LO2 cells. The selected RT-PCR array revealed a robust expression suppression of the fatty acid transport proteins (FATPs) by Andro treatment. Most importantly, we found that Andro consistently reduced the expression of FATP2 in both the oleic acid-treated LO2 cells and liver tissues of HFD-fed mice. Overexpression of FATP2 abolished the lipid-lowering effect of Andro in oleic acid-treated LO2 cells. Andro treatment also reduced the fatty acid uptake in oleic acid-treated LO2 cells, which was blunted by FATP2 overexpression. Collectively, our findings reveal a novel mechanism underlying the anti-steatosis effect of Andro by suppressing FATP2-mediated fatty acid uptake, suggesting the potential therapeutic application of Andro in the treatment of NAFLD. Graphical abstract

Highly Sensitive and Selective Detection of Melatonin in Biofluids by Antipyrine Based Fluorophore - Sathya Vijayakumar; Srinivasadesikan Venkatesan; Ming-Chang Lin; Padmini Vediappen (Journal of Fluorescence, 2023)

Residues of polychlorinated biphenyls (PCBs) in a wild predatory fish from an e-waste site in South China between 2009 and 2016 - Chang-an Li; Si-sheng Li; Ying Zhang; Yichao Huang; Lin Tao (Environmental Science and Pollution Research, 2023)

Gas-phase and PM2.5-bound phthalates in nail salons: characteristics, exposure via inhalation, and influencing factors - Chia-Ling Chang; Hui-Tzu Chen; Chung-Yu Chen; En-Yu Chen; Kuan-Ting Lin; Chien-Cheng Jung (Environmental Science and Pollution Research, 2023)

Life-course exposure to ambient fine particulate matter and hypertension in adulthood: a longitudinal cohort study - Cui Guo; Ly-yun Chang; Yacong Bo; Changqing Lin; Alexis K. H. Lau; Tony Tam; Xiang Qian Lao (Environmental Science and Pollution Research, 2023)

A symbiosis between Euploea butterflies and yeasts - Wan-Rou Lin; Yi-Ping Chang; Hui-Lin Wu; I-Cheng Hsu; Pi-Han Wang (Symbiosis, 2023)

Defect inspection of indoor components in buildings using deep learning object detection and augmented reality - Shun-Hsiang Hsu; Ho-Tin Hung; Yu-Qi Lin; Chia-Ming Chang (Earthquake Engineering and Engineering Vibration, 2023)

Associations between residential proximity to agricultural land use as pesticides exposure and birth outcomes - Kuna-Chun Chen; Shuo-Fang Lee; Shyang-Woei Lin; Jia-Shan Xie; Yu‐Hsun Chang; Lih-Ming Yiin; Chia-Jung Hsieh (Environmental Science and Pollution Research, 2022)

Application and Validation of an Ecological Quality Index, ISEP, in the Yellow Sea - Jae-Won Yoo; Yong-Woo Lee; Mi-Ra Park; Chang-Soo Kim; Sungtae Kim; Chae-Lin Lee; Su-Young Jeong; Dhongil Lim; Sung-Yong Oh (Journal of Marine Science and Engineering, 2022)
An ecological index of macrobenthic communities is an important tool for assessing the biological quality of habitats and ecosystems. We tested the performance of the inverse function of the Shannon–Wiener evenness proportion (ISEP) with data from the entire west coast of Korea, seasonally sampled from 2006 to 2008. Two validations were performed: (1) examination of the relationship between ISEP and environmental factors and (2) correspondence between the ISEP and the Pearson–Rosenberg (P-R) model for the species-abundance-biomass (SAB) patterns and taxonomical variations. The ISEP was significantly correlated with suspended solids but independent of other natural habitat conditions due to their low to moderate contamination levels. From this, ISEP performed as expected in transitional zones of low salinity and applications across habitats of various sediments. The SAB patterns and taxonomic variations along the ISEP grades showed marked similarities to the P-R model. The only departure was biomass, which increased after the normal status. The increase was interpreted as reflecting a healthier and more mature status. Taxonomic variation patterns and the taxa composition that characterized either poor or healthy status corresponded well with the P-R model. The conformity to the P-R model indicates the capability and potential applicability of the ISEP to other coastal systems.

Mesenchymal Stem Cell Secreted-Extracellular Vesicles are Involved in Chondrocyte Production and Reduce Adipogenesis during Stem Cell Differentiation - Yu-Chen Tsai; Tai-Shan Cheng; Hsiu-Jung Liao; Ming-Hsi Chuang; Hui-Ting Chen; Chun-Hung Chen; Kai-Ling Zhang; Chih-Hung Chang; Po-Cheng Lin; Chi-Ying F. Huang (Tissue Engineering and Regenerative Medicine, 2022)
Background: Extracellular vesicles (EVs) are derived from internal cellular compartments, and have potential as a diagnostic and therapeutic tool in degenerative disease associated with aging. Mesenchymal stem cells (MSCs) have become a promising tool for functional EVs production. This study investigated the efficacy of EVs and its effect on differentiation capacity. Methods: The characteristics of MSCs were evaluated by flow cytometry and stem cell differentiation analysis, and a production mode of functional EVs was scaled from MSCs. The concentration and size of EVs were quantitated by Nanoparticle Tracking Analysis (NTA). Western blot analysis was used to assess the protein expression of exosome-specific markers. The effects of MSC-derived EVs were assessed by chondrogenic and adipogenic differentiation analyses and histological observation. Results: The range of the particle size of adipose-derived stem cells (ADSCs)- and Wharton’s jelly -MSCs-derived EVs were from 130 to 150 nm as measured by NTA, which showed positive expression of exosomal markers. The chondrogenic induction ability was weakened in the absence of EVs in vitro . Interestingly, after EV administration, type II collagen, a major component in the cartilage extracellular matrix, was upregulated compared to the EV-free condition. Moreover, EVs decreased the lipid accumulation rate during adipogenic induction. Conclusion: The results indicated that the production model could facilitate production of effective EVs and further demonstrated the role of MSC-derived EVs in cell differentiation. MSC-derived EVs could be successfully used in cell-free therapy to guide chondrogenic differentiation of ADSC for future clinical applications in cartilage regeneration.

AIoT-Based Ergometer for Physical Training in Frail Elderly with Cognitive Decline: A Pilot Randomized Control Trial - Chih-Chun Lin; Li-Chieh Kuo; Yu-Sheng Lin; Chia-Ming Chang; Fang Wen Hu; Yi-Jing Chen; Chun-Tse Lin; Fong-Chin Su (Journal of Medical and Biological Engineering, 2022)
Purpose Reduced physical activity is reported in the elderly, especially in institutional residents. Institutionalized older adults exhibit a high prevalence of frailty. In this work, we developed an artificial intelligence of things (AIoT)-based feedback assistive strengthening ergometer (AIFASE), for the physical strengthening of the elderly with intelligent assistance. Methods We conducted a 12-week intervention in a long-term care facility. In total, 16 participants (84.38 ± 6.0 years; 4 males and 12 females) were recruited with 1:1 randomization of exercise to control groups. The muscle strength of the lower extremities, timed up and go test (TUG), and Short-form Physical Performance Battery (SPPB) of the participants were measured. The AIFASE system allows the clinical staff to record the personal physical performance of the elderly and generates personalized exercise prescriptions accordingly. AIFASE also displays the current usage status of all ergometers and the users’ physiological conditions. The algorithms were developed to generate warning alerts when the training workload was too large by personal physiological detection. AIFASE automatically customized the exercise prescription according to the user’s exercise performance. Results After a 12-week AIFASE intervention, the intervention group exhibited significant improvements in the strength of the hip flexor, Semi-Tandem Stand, and Tandem Stand. Conclusion In this study, we developed an AIoT ergometer that delivered customized physical training prescriptions to improve the physical performance of long-term care facility residents. We believe that the application of AIFASE will help improve the quality of institutional care.

Promoting effect of Fe/La loading on γ-Al2O3 catalyst for hydrolysis of carbonyl sulfur - Panting Gao; Yuran Li; Yuting Lin; Liping Chang; Tingyu Zhu (Environmental Science and Pollution Research, 2022)

In silico prediction of parkinsonian motor deficits-related neurotoxicants based on the adverse outcome pathway concept - Hung-Lin Kan; Chun-Wei Tung; Shao-En Chang; Ying-Chi Lin (Archives of Toxicology, 2022)

Potential risk from and prevention of phytoplankton outbreaks in blocking the cooling water system in a nuclear power plant on the Southeast China coast - Yu Wang; Xiaoyin Chen; Yingyue Lin; Shuyi Zhang; Lin Chang; Xiaoming Tang; Peng Xiang; Heshan Lin (Frontiers in Marine Science, 2022)
The invasion or aggregation of marine biota in coastal waters has become a common problem, threatening the safety of cooling water systems in the context of environmental and climate changes. However, studies on issues of coastal nuclear power plants from the view of marine ecology have mostly focused on the thermal effluent, entrainment effect on organisms, residual chlorine, radioactivity, etc. There is a lack of information on the safety of cooling water systems in nuclear power plants blocked by marine biota. Based on field and historical datasets, this study screened phytoplankton species that may potentially block the cooling water system of the Fuqing nuclear power plant on the Southeast China coast, identified the phytoplankton risk and a risk calendar, and established a catalog of risk phytoplankton species for the cooling water system. The screening criteria were simultaneously required as follows: (1) particle size of cells or group >2000 μm; (2) phytoplankton bloom or aggregation events occurred in surrounding areas; (3) and species abundance maintained at >0.5×10 5 cells/L in the surrounding area. Nine high-risk species were screened out that can easily form colonies, clusters, and groups, including Thalassiosira diporocyclus , Thalassiosira subtilis , Noctiluca scintillans , Phaeocystis globosa , Pseudo-nitzschia pungens , Pseudo-nitzschia delicatissima , Skeletonema costatum , Skeletonema dohrnii , Paralia sulcata . Due to small cells or the formation of short chains, some dominant phytoplankton species, even those with advantages in abundance and occurrence, had difficulty threatening the reliability of cooling water systems in nuclear power plants. The outbreak of different phytoplankton species varied daily, and the risk of blockage was highest from April to July. The biological characteristics, ecological mechanisms underlying outbreaks of high-risk phytoplankton species are reviewed and discussed, suggesting a high degree of temporal and spatial variability of blockage risk. Finally, main prevention and control measures used against high-risk phytoplankton species are provided to imply new ideas and methods for nuclear power plants. These strategies have very important practical and scientific significance.

Numerical Investigation on Performance Optimization of Offshore Sandwich Blast Walls with Different Honeycomb Cores Subjected to Blast Loading - Hong Lin; Chang Han; Lei Yang; Lin Zhang; Haochen Luan; Pingping Han; Hao Xu; Shuo Zhang (Journal of Marine Science and Engineering, 2022)
As an important protective facility on offshore platform, the blast wall is of great significance in resisting oil and gas explosions. Honeycomb structures are widely used due to their unique deformation and mechanical properties under dynamic impact loads. The aim of this research is to develop an optimized design for an offshore sandwich blast wall with different honeycomb cores. The uniqueness of this paper is providing the quantitative optimization scheme for topological configurations and unit cell geometric parameters of honeycomb structures according to mass consistency and the proposed synthetic evaluation index of anti-blast performance. By using the numerical simulation software ANSYS/LS-DYNA, the CONWEP algorithm was first validated and then adopted to conduct the dynamical performance analysis of the honeycomb blast wall. For comparison purposes, simulating studies on a series of different blast walls were carried out by considering various influential parameters. According to different criteria, the blast resistance of the sandwich honeycomb structures was evaluated. It is found that the sandwich plate with concave arc honeycomb core has the best anti-blast performance compared to that of arrow honeycomb core and concave hexagonal honeycomb core. For the concave arc honeycomb structure, the geometric parameters such as concave angle and aspect ratio of honeycomb unit cell have great influence on the blast-resistance performance. Moreover, the concave arc honeycomb structure with positive gradient arrangement has better anti-blast performance than the negative one. The curved blast wall with the curvature of 1/20 achieves better anti-blast performance than the flat blast wall.

Protective effect of ginsenoside Rd on military aviation noise-induced cochlear hair cell damage in guinea pigs - Xue-min Chen; Yu-hui Liu; Shuai-fei Ji; Xin-miao Xue; Lin-lin Wang; Min Zhang; Yao-ming Chang; Xiao-cheng Wang (Environmental Science and Pollution Research, 2022)

A study of peatland-derived dissolved organic matter from headstream to sea using multiple analytical tools - François L. L. Muller; Kuei-Chen Chang; Yu-Chieh Wang; Chon-Lin Lee (Environmental Science and Pollution Research, 2022)

7,8-Dihydroxyflavone attenuates the virulence of Staphylococcus aureus by inhibiting alpha-hemolysin - Nan Bian; Xiangqian Chen; Xinran Ren; Zishu Yu; Mengli Jin; Xiaoyu Chen; Chang Liu; Yanhe Luan; Lin Wei; Ying Chen; Wu Song; Yicheng Zhao; et al. (World Journal of Microbiology and Biotechnology, 2022)

A 10-miRNA risk score-based prediction model for pathological complete response to neoadjuvant chemotherapy in hormone receptor-positive breast cancer - Chang Gong; Ziliang Cheng; Yaping Yang; Jun Shen; Yingying Zhu; Li Ling; Wanyi Lin; Zhigang Yu; Zhihua Li; Weige Tan; Chushan Zheng; Wenbo Zheng; et al. (Science China Life Sciences, 2022)

Multi-stage melt impregnation and magma–seawater interaction in a slow-spreading oceanic lithosphere: constraints from cumulates in the Lagkorco ophiolite (central Tibet) - Wei-Qi Zhang; Chuan-Zhou Liu; Tong Liu; Chang Zhang; Zhen-Yu Zhang; Xiao-Ni Li; Zhen Zhang; Yin-Zheng Lin (Contributions to Mineralogy and Petrology, 2022)

Numerical analysis of pile—slope stability and the soil arching around two adjacent piles - Chien-Yuan Chen; Chun-Kai Chang; Yu-Shan Lin (Journal of Mountain Science, 2022)

Surfactin isoforms isolated from a mushroom derived Bacillus halotolerans DMG-7-2 - Guo-Feng Zhou; Lin Yang; Shu-Hua Zhang; Yi Wang; Yu Yang; Rui Xu; Xue Zhao; Dan Nie; Junjie Shan; Cheng-Bin Cui; Chang-Wei Li (Natural Product Research, 2022)

Evaluation of the Potential of the Hard Clam (Meretrix meretrix) Shell Which Can Be Used as the Bioindicator for Heavy Metal Accumulation - Yen-Ting Lin; Fang-Chi Chang; Ming-Tsung Chung; Ze-Kai Li; Chang-Chuan Chan; Ying-Sheng Huang; Kuo-Fang Huang; Yu-San Han (Fishes, 2022)
Clams, Meretrix meretrix, were one of the favorite aquatic products in Taiwan and the world. It was reported that the water pollutants such as heavy metals and chemicals might accumulate in the clam body and shell through filter-feeding behavior. Thus, the bivalves could be used as bioindicators in the aquatic environment. The present study analyzed 20 trace elements, Mg, Sr, Li, Cd, Ba, Mn, Al, U, Ti, Pb, Nd, B, S, Zn, Fe, P, Na, K, Cu, and Ni, in the shells of the clams collected from the wild coastal area and cultured ponds to evaluate which elements have the potential to be biomarkers. The concentrations of 20 elements were detected by Solution-Based Inductively Coupled Plasma Mass Spectrometry (SB-ICPMS). Among them, Cd, Al, U, Ti, Nd, S, and K were below the detection limit. The remaining elements were analyzed for accumulation. The levels of Zn, Fe, and Ni possess high variation in an identical environment; so, a PCA was conducted without these three elements to reduce noise. The PCA result proved that the clam could absorb specific trace elements from the habitat. After a period of time, the contents of the absorption in the shells of the clams living in an identical environment became more similar. The analyzed element, Pb, was not found with a special difference in this study. The levels of Na, Sr, Mg, B, Mn, P, Ba, Li, and Cu reflected different sampling sites, which suggested that these elements in the species M. meretrix had the potential to be used as biomarkers for assessing heavy metal accumulation in the environment.

The influence of climate change on the allocation efficiency of new and tradition energy - Kuei-Ying Huang; Yung-ho Chiu; Tzu-Han Chang; Tai-Yu Lin (Environmental Science and Pollution Research, 2022)

Glibenclamide Directly Prevents Neuroinflammation by Targeting SUR1-TRPM4-Mediated NLRP3 Inflammasome Activation In Microglia - Yihua He; Yuan Chang; Yuqin Peng; Juan Zhu; Kewei Liu; Jiancong Chen; Yongming Wu; Zhong Ji; Zhenzhou Lin; Shengnan Wang; Sohan Gupta; Nailiang Zang; et al. (Molecular Neurobiology, 2022)

Plasma Matrix Metalloproeteinase-9 Is Associated with Seizure and Angioarchitecture Changes in Brain Arteriovenous Malformations - Yo-Tsen Liu; Cheng-Chia Lee; Chun-Fu Lin; Hsiu-Mei Wu; Wan-Yuo Guo; Huai-Che Yang; Feng-Chi Chang; Kang-Du Liou; Chung-Jung Lin (Molecular Neurobiology, 2022)

Vector angle grouping-based solution separation for multipath/NLOS detection and exclusion with the enhancement of doppler test - Jin Chang; Xingqun Zhan; Yawei Zhai; Shizhuang Wang; Kui Lin; Rong Yang (GPS Solutions, 2022)

Simulated Short- and Long-Term Deformation in Coastal Karst Caves - Chunxiu Lin; Chang Xia; Hong Zhang; Zhen Liu; Cuiying Zhou (Journal of Marine Science and Engineering, 2022)
The self-balanced pressure arch theory is an important basis for excavation support in karst caves, but it is difficult to quantify the empirical theory in coastal areas. In addition, the rheological effects of karst strata could pose a hazard to engineering. Therefore, this study investigated the rheological mechanism under the self-balanced pressure arch effect, and we proposed a mesoscopic unit rheological model for clay minerals in a water-rich environment. With the discrete element method (DEM), we realized the numerical modeling of the rheological model. Then, the proposed model is validated by a case study of foundation excavation in the coastal karst area of China. The mesoscopic mechanical characteristics of caves considering the influence of pressure arch are analyzed. The results show that the self-balance of the caverns mainly lies in the mesoscopic mineral strength and local stress. With the rheological controlled model, the final predicted convergent deformation of the foundation has an error of less than 10% compared with the field monitoring data. In this study, we can quantitively describe the self-balance effect of the pressure arch surrounding the caves and reveal the rheological mechanism. The proposed model can be applied to similar engineering with careful calibration and provide safety guidance.

Stochastic analysis of the variability of groundwater flow fields in heterogeneous confined aquifers of variable thickness - Ching-Min Chang; Chuen-Fa Ni; We-Ci Li; Chi-Ping Lin; I-Hsian Lee (Stochastic Environmental Research and Risk Assessment, 2022)

Activation of Dopamine D2 Receptors Alleviates Neuronal Hyperexcitability in the Lateral Entorhinal Cortex via Inhibition of HCN Current in a Rat Model of Chronic Inflammatory Pain - Shi-Hao Gao; Yong Tao; Yang Zhu; Hao Huang; Lin-Lin Shen; Chang-Yue Gao (Neuroscience Bulletin, 2022)

Hippocampal Iron Accumulation Impairs Synapses and Memory via Suppressing Furin Expression and Downregulating BDNF Maturation - Yating Zhang; Xue Bai; Yi Zhang; Shanshan Yao; Yiduo Cui; Lin-Hao You; Peng Yu; Yan-Zhong Chang; Guofen Gao (Molecular Neurobiology, 2022)

Knockdown of lncRNA MIAT attenuated lipopolysaccharide-induced microglial cells injury by sponging miR-613 - Jia Li; Chang-Lin Zou; Zhi-Ming Zhang; Feng Xue (Mammalian Genome, 2022)

Towards less invasive molecular diagnostics for endometrial cancer: massively parallel sequencing of endometrial lavage specimens in women attending for an office hysteroscopy - Angel Chao; Kai-Yun Wu; Chiao-Yun Lin; Yun-Shien Lee; Huei-Jean Huang; Yun-Hsin Tang; Cindy Hsuan Weng; An-Shine Chao; Ting-Chang Chang; Chyong-Huey Lai; Ren-Chin Wu (Journal of Molecular Medicine, 2022)

Identification and QTL mapping of important agronomic traits based on rice short-wide grain CSSL-Z752 with restorer line Xihui 18 as background - Lin-Jun Cai; Han Yun; Xiao-Long Zhong; Dan Du; Xi-Man Peng; Ji-Chao Dai; Zhen-Lin Yang; Fang-Ming Zhao; Chang-Wei Zhang (Cereal Research Communications, 2022)

Dynamic Performance and Crashworthiness Assessment of Honeycomb Reinforced Tubular Pipe in the Jacket Platform under Ship Collision - Hong Lin; Chang Han; Lei Yang; Hassan Karampour; Haochen Luan; Pingping Han; Hao Xu; Shuo Zhang (Journal of Marine Science and Engineering, 2022)
The collision between the pipe legs of jacket platforms and bypassing ships is of great concern for the safety assessment of platforms. Honeycomb structures have been widely used owing to their unique deformation and mechanical properties under dynamic impact loads. In this paper, two typical honeycomb structures, namely hexagonal honeycomb and arrow honeycomb, were constructed for the impact protection of inclined pipe legs in jacket platforms, and the present study aimed to assess the dynamical performance and crushing resistance of the designed honeycomb reinforced structure under ship collision by using the numerical simulation software ANSYS/LS-DYNA. The dynamical performance of the honeycomb reinforced pipe leg was investigated considering various influential parameters, including the impact velocity and impact direction. The crashworthiness of the two types of honeycomb was evaluated and compared by different criteria, namely the maximum impact depth (δmax), specific energy absorption (SEA) and the proposed index offset sliding (OS). The results demonstrated that both the hexagonal honeycomb structure and the arrow honeycomb structure can reduce the damage of inclined pipe legs caused by ship collision, while the hexagonal honeycomb can provide the better anti-collision capacity, which can well reduce the offset sliding and better protect the pipe leg from ship collision.

Understorey light environment impacts on seedling establishment and growth in a typhoon-disturbed tropical forest - Kuo-Jung Chao; Yung-Chiau Lin; Guo-Zhang Michael Song; Chien-Hui Liao; Yau-Lun Kuo; Chang-Fu Hsieh; Eugene W. Schupp (Plant Ecology, 2022)

Biomechanical Analysis of Mandibular Implant-Assisted Removable Partial Denture with Distal Extension - Yung-Chung Chen; Chi-Lun Lin; Chen-Han Yu; Hung-Chih Chang; Yang-Ming Lin; Jia-Wei Lin (Journal of Medical and Biological Engineering, 2022)

Association of cognitive impairment and reduced cortical thickness in prefrontal cortex and anterior cingulate cortex with treatment-resistant depression - Mu-Hong Chen; Wan-Chen Chang; Pei-Chi Tu; Wei-Chen Lin; Cheng-Ta Li; Wen-Sheng Huang; Ya-Mei Bai; Shih-Jen Tsai; Tung-Ping Su (Brain Imaging and Behavior, 2022)

Plant secondary metabolite and temperature determine the prevalence of Arsenophonus endosymbionts in aphid populations - Chun‐Yan Chang; Xiao‐Wan Sun; Pan‐Pan Tian; Ning‐Hui Miao; Yu‐Lin Zhang; Xiang‐Dong Liu (Environmental Microbiology, 2022)
Summary Transmission rate and role in hosts contribute to the prevalence of an endosymbiont. However, factors affecting transmission and role of facultative endosymbionts are still not well understood. Here, we illustrated that host plants and environmental temperatures affected the transmission, relative abundance and role of Arsenophonus in the cotton aphid Aphis gossypii . The transmission rate of this endosymbiont from mother aphids to offspring was relatively lower. High temperatures impeded the transmission, and infection rates declined as aphids were exposed to 30°C. Contents of amino acids and secondary metabolites were remarkably different among host plants. Aphids feeding on zucchini leaves containing a higher titre of amino acids and lower secondary metabolites harboured a relatively lower abundance of Arsenophonus . Concentrations of an amino acid and a plant secondary metabolite, cucurbitacin B, in aphid diet were not associated with Arsenophonus abundance. However, gossypol, another plant secondary metabolite, was strongly related with the abundance. Arsenophonus imparted a fitness benefit to aphids, and the benefit was dependent on host plants and gossypol concentration. In sum, plant secondary metabolite and environmental temperature affect transmission, relative abundance and role of Arsenophonus , which determine the endosymbiont prevalence in aphid populations.

Vertical patterns of chlorophyll a in the euphotic layer are related to mesoscale eddies in the South China Sea - Mei-Lin Wu; You-Shao Wang; Yu-Tu Wang; Fu-Lin Sun; Xiaomei Li; Fang-Fang Gu; Jing-Chang Xiang (Frontiers in Marine Science, 2022)
Phytoplankton closely connects with the hydrodynamics and biogeochemical environment of the ocean. While research focusing on both the physiochemical factors and hydrodynamics regulating phytoplankton has already been conducted, the coupling mechanism between mesoscale eddies and the vertical distribution of phyto plankton in the South China Sea (SCS) is still not well understood. Here, phytoplankton was studied under one weak-cold and two warm eddies along the 18°N transect in the SCS. The results show that the vertical distribution of chlorophyll (chl- a ) presented a similar pattern at all four sampling stations. The mixed layer is less than 50 m. It is the same as the meridional salinity gradients that may be distinguished above a depth of 60 m. The subsurface chlorophyll maximum at the edge of a warm (WI) and cold eddy (CI) at E413 and E411 was shallower than that at the edge of a warm eddy (WII) at E407 and E409, indicating that temperature and salinity may be the important driving factors. On the whole, mesoscale eddies had a significant influence on the vertical pattern of chl- a in the SCS during the study period.

Assessing the effective spatial characteristics of input features through physics-informed machine learning models in inundation forecasting during typhoons - Bing-Chen Jhong; Chung-Yi Lin; You-Da Jhong; Hsiang-Kuan Chang; Jung-Lien Chu; Hsi-Ting Fang (Hydrological Sciences Journal, 2022)

Microplastic prevalence in marine fish from onshore Beibu Gulf, South China Sea - Jayamini Bimali Koongolla; Lang Lin; Chang-Ping Yang; Yun-Feng Pan; Heng-Xiang Li; Shan Liu; Xiang-Rong Xu (Frontiers in Marine Science, 2022)
In recent years, microplastics have been widely detected in marine fish and may pose potential risks to fish and human health. Even though microplastic pollution is a critical issue, it represents as yet non-quantified threat for some context in the marine environment. In this study, 271 individuals comprising 32 species of marine fish collected from Beibu Gulf were examined for microplastic prevalence, with an aim to provide data on the abundance, physical classification, and chemical characterization of microplastics in the great bay along South China Sea. The results showed that the occurrence rate of microplastics was 93.7%, and the average abundance of microplastics was 1.02 ± 0.18 items per individual (ranging from 0.03 to 4.00 items per individual). Microplastic accumulation was observed with a great variation in different species, body sizes, living habitats, and feeding habits of marine fishes. The dominant polymers identified by μ-FTIR were polyethylene terephthalate and polypropylene. Fibers, smaller sizes (<1 mm), and transparent color were the major characteristics of the detected microplastics, which might be important factors affecting the bioaccumulation. The present study revealed that microplastics in marine fish is a widespread issue in onshore Beibu Gulf.

Real-time Neural-network-based Ensemble Typhoon Flood Forecasting Model with Self-organizing Map Cluster Analysis: A Case Study on the Wu River Basin in Taiwan - You-Da Jhong; Hsin-Ping Lin; Chang-Shian Chen; Bing-Chen Jhong (Water Resources Management, 2022)

Development of wheat-Dasypyrum villosum T6V#4S·6AL translocation lines with enhanced inheritance for powdery mildew resistance - Xiaolan Ma; Yanan Chang; Jingnan Chen; Mei Yu; Baicui Wang; Xingguo Ye; Zhishan Lin (Theoretical and Applied Genetics, 2022)

Correction to: Exercise Rehabilitation and/or Astragaloside Attenuate Amyloid-beta Pathology by Reversing BDNF/TrkB Signaling Deficits and Mitochondrial Dysfunction - Yu-Lin Wang; Chung-Ching Chio; Shu-Chun Kuo; Chao-Hung Yeh; Jui-Ti Ma; Wen-Pin Liu; Mao-Tsun Lin; Kao-Chang Lin; Ching-Ping Chang (Molecular Neurobiology, 2022)

Genetic testing enables a precision medicine approach for nephrolithiasis and nephrocalcinosis in pediatrics: a single-center cohort - Lin Huang; Chang Qi; Gaohong Zhu; Juanjuan Ding; Li Yuan; Jie Sun; Xuelian He; Xiaowen Wang (Molecular Genetics and Genomics, 2022)
Objective Hereditary factors are the main cause of pediatric nephrolithiasis (NL)/nephrocalcinosis (NC). We summarized the genotype–phenotype correlation of hereditary NL/NC in our center, to evaluate the role of genetic testing in early diagnosis. Methods The clinical data of 32 NL/NC cases, which were suspected to have an inherited basis, were retrospectively analyzed from May 2017 to August 2020. The trio-whole exome sequencing was used as the main approach for genetic testing, variants were confirmed by Sanger sequencing, and pathogenicity analysis according to protein function was predicted with custom-developed software. Results Causative monogenic mutations were detected in 24 of 32 NL/NC patients, and copy number variation was detected in one patient. A summary of manifestations in patients with inherited diseases revealed a significant degree of growth retardation, increased urinary excretion of the low-molecular weight protein, hypercalciuria, electrolyte imbalances, and young age of onset to be common in heredity disease. In addition, some patients had abnormal renal function (3 ppm 25). The most frequent pathology identified was distal renal tubular acidosis (with inclusion of SLC4A1 , ATP6V1B1 , and ATP6VOA4 genes), followed by Dent disease ( CLCN5 and OCRL1 genes), primary hyperoxaluria (PH) ( AGXT and HOGA1 genes) and Kabuki syndrome ( KMT2D gene), which was more likely to present as NC or recurrent stone and having a higher correlation with a specific biochemical phenotype and extrarenal phenotype. Conclusion The etiology of NL/NC is heterogeneous. This study explored in depth the relationship between phenotype and genotype in 32 patients, and confirmed that genetic testing and clinical phenotype evaluation enable the precision medicine approach to treating patients.

Fine particulate matter measured by satellites predicts the risk of age-related macular degeneration in a longitudinal cohort study - Chung-Ling Liang; Chi-Min Wang; Chau-Ren Jung; Ya-Chu Chang; Chun-Ju Lin; Yu-Ting Lin; Bing-Fang Hwang (Environmental Science and Pollution Research, 2022)

Dapagliflozin protects against doxorubicin-induced cardiotoxicity by restoring STAT3 - Wei-Ting Chang; Jhih-Yuan Shih; Yu-Wen Lin; Zhih-Cherng Chen; Wei-Chih Kan; Tsung-Hsien Lin; Chon-Seng Hong (Archives of Toxicology, 2022)

Streptococcus vulneris sp. nov., isolated from wound of patient with diabetic foot ulcer (DFU) - Jen-hao Chung; Li-Ting Wang; Yi-Sheng Chen; Yun-Shien Lee; Shih-Ting Lin; Yu-Chung Chang; Hui-Chung Wu; Yu-Jie Dai; Wei-Qi Liao; Fan-Ching Kao; Jui-hsiang Li (Archives of Microbiology, 2022)

Estrogenic and anti-neutrophilic inflammatory phenanthrenes from Juncus effusus L. - Hao-Chun Hu; Yi-Hong Tsai; Yu-Che Chuang; Kuei-Hung Lai; Yu-Ming Hsu; Tsong-Long Hwang; Chih-Chan Lin; Ferenc Fülöp; Yang-Chang Wu; Szu-Yin Yu; Yu-Ting Kuo; Fang-Rong Chang (Natural Product Research, 2022)

Characterization of chemical constituents with their antioxidant and anti-melanogenesis activities from the roots of Ampelopsis japonica - Chia-Lin Lee; Yun-Lian Jhan; Hsiu-Mei Chiang; Yi-Hung Chen; Chao-Jung Chen; Yuan-Shiun Chang (Natural Product Research, 2022)

An optimal integration of multiple machine learning techniques to real-time reservoir inflow forecasting - I.-Hang Huang; Ming-Jui Chang; Gwo-Fong Lin (Stochastic Environmental Research and Risk Assessment, 2022)

Lactobacillus plantarum PS128 Promotes Intestinal Motility, Mucin Production, and Serotonin Signaling in Mice - Chih-Ming Chen; Chien-Chen Wu; Chin-Lin Huang; Min-Yu Chang; Shih-Hsuan Cheng; Ching-Ting Lin; Ying-Chieh Tsai (Probiotics and Antimicrobial Proteins, 2022)
Lactobacillus plantarum PS128 has been reported as a psychobiotic to improve mental health through the gut–brain axis in experimental animal models. To explore its mechanism of action in the gut, this study aimed to analyze the effects of L. plantarum PS128 ingestion on naïve and loperamide (Lop)-induced constipation mice. We found that, in the two mouse models, the weight, number, and water content of feces in the L. plantarum PS128 group were higher than those in the vehicle control group. Histological observation revealed that L. plantarum PS128 increased the level of colonic mucins including the major mucin MUC2. In addition, the charcoal meal test showed that L. plantarum PS128 significantly increased the small intestine transit in naïve mice, but not in the Lop-treated mice. Since intestinal serotonin has been found to modulate motility, we further analyzed the expression of genes related to serotonin signal transduction in the small intestine of naïve mice. The results showed that L. plantarum PS128 significantly altered the expression levels of Tph1 , Chga , Slc6a4 , and Htr4 , but did not affect the expression levels of Tph2 , Htr3a , and Maoa . Furthermore, immunohistochemistry revealed that L. plantarum PS128 significantly increased the number of serotonin-containing intestinal cells in mice. Taken together, our results suggest that L. plantarum PS128 could promote intestinal motility, mucin production, and serotonin signal transduction, leading to a laxative effect in mice.

Using DeepLab v3 + -based semantic segmentation to evaluate platelet activation - Tsung-Chen Kuo; Ting-Wei Cheng; Ching-Kai Lin; Ming-Che Chang; Kuang-Yao Cheng; Yun-Chien Cheng (Medical & Biological Engineering & Computing, 2022)

TREM-2 mediates dendritic cell–induced NO to suppress Th17 activation and ameliorate chronic kidney diseases - Ching-Cheng Lin; Ti-Yung Chang; Yong-Chen Lu; Yun-Syuan Wu; Wei Huang; Wei-Chi Lo; Guan-Fu Liu; Wei-Chan Hsu; Pamela S. Ohashi; Tak W. Mak; Jong-Ling Fuh; Hui-Chen Chen; et al. (Journal of Molecular Medicine, 2022)

Determination of glyphosate, aminomethylphosphonic acid, and glufosinate in river water and sediments using microwave-assisted rapid derivatization and LC–MS/MS - Jyun-Fong Lin; Fang-Chih Chang; Jenn-Feng Sheen (Environmental Science and Pollution Research, 2022)

Assessing the Effects of Ocean Warming and Acidification on the Seagrass Thalassia hemprichii - Pi-Jen Liu; Hong-Fong Chang; Anderson B. Mayfield; Hsing-Juh Lin (Journal of Marine Science and Engineering, 2022)
Seagrass beds serve as important carbon sinks, and it is thought that increasing the quantity and quality of such sinks could help to slow the rate of global climate change. Therefore, it will be important to (1) gain a better understanding of seagrass bed metabolism and (2) document how these high-productivity ecosystems are impacted by climate change-associated factors, such as ocean acidification (OA) and ocean warming (OW). A mesocosm-based approach was taken herein in which a tropical, Western Pacific seagrass species Thalassia hemprichii was cultured under either control or OA-simulating conditions; the temperature was gradually increased from 25 to 31 °C for both CO2 enrichment treatments, and it was hypothesized that this species would respond positively to OA and elevated temperature. After 12 weeks of exposure, OA (~1200 ppm) led to (1) increases in underground biomass and root C:N ratios and (2) decreases in root nitrogen content. Rising temperatures (25 to 31 °C) increased the maximum quantum yield of photosystem II (Fv:Fm), productivity, leaf growth rate, decomposition rate, and carbon sequestration, but decreased the rate of shoot density increase and the carbon content of the leaves; this indicates that warming alone does not increase the short-term carbon sink capacity of this seagrass species. Under high CO2 and the highest temperature employed (31 °C), this seagrass demonstrated its highest productivity, Fv:Fm, leaf growth rate, and carbon sequestration. Collectively, then, it appears that high CO2 levels offset the negative effects of high temperature on this seagrass species. Whether this pattern is maintained at temperatures that actually induce marked seagrass stress (likely beginning at 33–34 °C in Southern Taiwan) should be the focus of future research.

Shear Instability and Turbulent Mixing in the Stratified Shear Flow Behind a Topographic Ridge at High Reynolds Number - Jia-Lin Chen; Xiao Yu; Ming-Huei Chang; Sen Jan; Yiing Jang Yang; Ren-Chieh Lien (Frontiers in Marine Science, 2022)
Observations on the lee of a topographic ridge show that the turbulence kinetic energy (TKE) dissipation rate due to shear instabilities is three orders of magnitude higher than the typical value in the open ocean. Laboratory-scale studies at low Reynolds number suggest that high turbulent dissipation occurs primarily within the core region of shear instabilities. However, field-scale studies indicate that high turbulence is mainly populated along the braids of shear instabilities. In this study, a high-resolution, resolving the Ozmidov-scale, non-hydrostatic model with Large Eddy Simulation (LES) turbulent closure is applied to investigate dominant mechanisms that control the spatial and temporal scales of shear instabilities and resulting mixing in stratified shear flow at high Reynolds number. The simulated density variance dissipation rate is elevated in the cusp-like bands of shear instabilities with a specific period, consistent with the acoustic backscatter taken by shipboard echo sounder. The vertical length scale of each cusp-like band is nearly half of the vertical length scale of the internal lee wave. However, it is consistent with instabilities originating from a shear layer based on linear stability theory. The model results indicate that the length scale and/or the period of shear instabilities are the key parameters to the mixing enhancement that increases with lateral Froude number Fr L , i.e. stronger shear and/or steeper ridge.

A New Non-stationary Hydrological Drought Index Encompassing Climate Indices and Modified Reservoir Index as Covariates - Youxin Wang; Tao Peng; Qingxia Lin; Vijay P. Singh; Xiaohua Dong; Chen Chen; Ji Liu; Wenjuan Chang; Gaoxu Wang (Water Resources Management, 2022)

Exercise Rehabilitation and/or Astragaloside Attenuate Amyloid-beta Pathology by Reversing BDNF/TrkB Signaling Deficits and Mitochondrial Dysfunction - Yu-Lin Wang; Chung-Ching Chio; Shu-Chun Kuo; Chao-Hung Yeh; Jui-Ti Ma; Wen-Pin Liu; Mao-Tsun Lin; Kao-Chang Lin; Ching-Ping Chang (Molecular Neurobiology, 2022)

Dominant Fungal Epiphytes Promote Growth of the Invasive Plant Ipomoea cairica Through Hormone Interactions - Hua Xu; Ping Chang; Shaoshan Li; Jianguo Lu; Xuejun Lin; Can Xie (Journal of Plant Growth Regulation, 2022)

Study on water resources carrying capacity in Zhuanglang River Basin - Wen Xu; Chang Zhou; Bingrui Liu; Dongxue Wang; Xingzhu Zhao; Xiaojing Yang; Xiaotao Zhu; Zimu Lin (Environmental Monitoring and Assessment, 2022)
With the rapid development of China’s social economy, the phenomenon of unbalanced regional economic development is increasingly obvious. The shortage of water resources in northwest China is an important constraint to local development. The study on the water resources carrying capacity of the Zhuanglang River Basin plays an important role in the development of local economy; thus, we evaluate the water resources situation of Zhuanglang River Basin by using hydrology-related calculation method, combining with field investigation, visiting relevant departments, and referring to relevant data. Meanwhile, the water resources carrying capacity of 3 counties and 12 townships in the Zhuanglang River Basin in the current year are studied and analyzed based on methods such as fuzzy comprehensive evaluation model and quantitative calculation. Results indicate that the carrying capacity of water resources in Zhuanglang river basin can mostly meet the needs of township, but it is necessary to further optimize the water resources carrying capacity of the Zhuanglang River Basin from the four systems of water resources, society, economy, and ecology in the future. Besides, the results of quantitative calculation show that the maximum economic scale that water resources can withstand in most areas of the Zhuanglang River Basin is the overall well-off level, that is, the per capita domestic water is 80L/(d· person), and the per capita GDP is 10000 yuan/person. But there is still a certain gap to achieve the level, when the people are well-off in an all-round way, the two indexes are correspondently raised to 120L/(d· person), and the per capita GDP is 30,000 yuan/person.

Insight into the dynamic microbial community and core bacteria in composting from different sources by advanced bioinformatics methods - Yabin Zhan; Yuan Chang; Yueyue Tao; Hao Zhang; Yongfeng Lin; Jie Deng; Tiantian Ma; Guochun Ding; Yuquan Wei; Ji Li (Environmental Science and Pollution Research, 2022)

Hypothermal Effects on Energy Supply for Ionocytes in Gills of Freshwater- and Seawater-Acclimated Milkfish, Chanos chanos - Chia-Hao Chang; Chia-Jui Liu; Wei-Jie Lu; Li-Yang Wu; Kuang-Jie Lai; Yu-Ting Lin; Tsung-Han Lee (Frontiers in Marine Science, 2022)
The milkfish, Chanos chanos , is an important aquaculture species that can be cultured in freshwater (FW) and seawater (SW) ponds because of its high euryhalinity. In winter, cold snap leading to high mortality of this tropical species is a critical issue for the aquaculture industry in Taiwan. Under hypothermal stress, however, changes in energy supply for osmoregulation of this euryhaline species is intriguing. In this study, we used an antibody against glycogen phosphorylase (GP) to identify glycogen-rich (GR) cells distributed adjacent to the mitochondria-rich (MR) ionocytes in milkfish gills. Glucose transporter 1 (GLUT1), which plays a major role in energy supply, was also identified and localized in GR cells. Moreover, the expression of indicators of aerobic metabolism and energy production, citrate synthase (CS) and cytochrome c oxidase (COX), were analyzed in gills of FW- and SW-acclimated milkfish to reveal different strategies of energy utilization under hypothermal stress. When exposed to a low-temperature environment, SW individuals used branchial glycogen and lactate to match the energy demands of aerobic metabolism in ionocytes, and elevated aerobic capacity to support and maintain normal functions in gills. However, branchial glycogen mainly localized in the GR cells of FW milkfish was not utilized under hypothermal stress. Meanwhile, a similar level of branchial COX activity and COXIV protein abundance at low temperatures between FW and SW milkfish indicated similar energy requirements in gills. This suggested that another source, but not branchial glycogen, maintained the energy demand in FW milkfish. The present study illustrated differential energy supply strategies in gills between SW- and FW-acclimated milkfish for osmoregulation under low temperatures.

A Comprehensive Correlation Study of Structured Soils in Coastal Area of South China about Structural Characteristics - Chunxiu Lin; Chang Xia; Zhen Liu; Cuiying Zhou (Journal of Marine Science and Engineering, 2022)
Granite residual soil is a common engineering material, and its mechanical properties are of great importance to engineering safety. This kind of soil presents obvious structural characteristics, and many researchers have emphasized the significance of its structural features. According to previous experiments, from a macroscopic perspective, many researchers have investigated the structural relationship between undisturbed and remolded soils, but few studies have considered it in the mesoscopic aspect. Adopting DEM (a mesomechanical simulation method), we can study how the structure affects the mechanical process between undisturbed and remolded soil. Therefore, this paper combines DEM with laboratory tests to study the structural characteristic correlation between undisturbed and remolded soil. The results indicate that a weak cohesion effect exists in undisturbed soil, and the damage of weak cohesion elements accompanies the failure process. Weak cohesion elements in undisturbed soil cause inhomogeneities in deformation, stress state, and damage accumulation, which ultimately causes differences in strength curves. This paper explains the mechanism of the structural effect on mechanical evolution from a mesomechanical perspective. The DEM simulation method proposed in this paper can be applied to structured soils and better guide engineering practice.

Duration of Induced Metallothionein is a Critical Factor in the Cadmium-Resistance Among Goldfish (Carassius auratus) and Common Carp (Cyprinus carpio) - Feng Ming Chang; Chia Hao Lin; Su Mei Wu (Bulletin of Environmental Contamination and Toxicology, 2022)

Selenium Alleviates Inflammation in Staphylococcus aureus-Induced Mastitis via MerTK-Dependent Activation of the PI3K/Akt/mTOR Pathway in Mice - Si-jie Chen; Chen-yuan Zhang; Di Yu; Chang-jie Lin; Hao-jun Xu; Chang-min Hu (Biological Trace Element Research, 2022)

Road performance and microscopic action mechanism of low liquid limit silt solidified by AT curing agent - Jin Chang; Jian-Qing Jiang; Ming Lei; Shi-Lin Luo; Guang-Feng He; Jia-Yi Lin (Arabian Journal of Geosciences, 2022)

The significance of riparian communities in the energy flow of subtropical stream ecosystems - Yi-Chang Liao; An-Cheng Lin; Han-Ni Tsai; Yu-Ting Yen; Chyng-Shyan Tzeng; Man-Miao Yang; Hsing-Juh Lin (Aquatic Sciences, 2022)

Potential Plasticity of Artificial Feed Preference in Juvenile Pharaoh Cuttlefish (Sepia pharaonis) Through Progressive Training Programs - Chia-Huan Ma; Chih-Hung Lin; Yung-Cheng Chang; Hung-Tai Lee; Chyng-Hwa Liou; Te-Hua Hsu (Frontiers in Marine Science, 2022)
The cuttlefish is a commercially important marine species across the world; however, due to the lack of appropriate artificial feed, there is limited future aquaculture development of the cuttlefish. We proposed a novel process comprising (1) feed preference tests and (2) progressive training programs. Through this process, artificial diets can become more suitable for pharaoh cuttlefish ( Sepia pharaonis ). Feed preference tests (based on vision, touch, and smell) revealed that pharaoh cuttlefish preferred rod-shaped feed to flat rod-shaped or ball-shaped feed, moist feed over dry feed (DF), and DF with agar coating to DF without agar coating. Without olfactory training, some cuttlefish refused to eat artificial feed and eventually died. Through progressive training programs (3- and 6-week programs), a survival rate of >80% was achieved. Although the artificial diets examined in this study resulted in a lower conversion ratio for S. pharaonis than for fresh shrimp, available artificial feed can potentially be adopted for cuttlefish aquaculture through the use of our progressive training program.

Eichleriella aculeobasidiata sp. nov. (Auriculariales, Basidiomycota) evidenced by morphological characters and phylogenetic analyses in China - Hui Wang; Dong-Qiong Wang; Chang-Lin Zhao (Kew Bulletin, 2022)

Exogenous ascorbic acid application alleviates cadmium toxicity in seedlings of two wheat (Triticum aestivum L.) varieties by reducing cadmium uptake and enhancing antioxidative capacity - Zhen Zhou; Chang Wei; Haitao Liu; Qiujuan Jiao; Gezi Li; Jingjing Zhang; Biao Zhang; Weihuan Jin; Di Lin; Guo Chen; Suqin Yang (Environmental Science and Pollution Research, 2022)

Engineering osteoarthritic cartilage model through differentiating senescent human mesenchymal stem cells for testing disease-modifying drugs - Ning Wang; Yuchen He; Silvia Liu; Meagan J. Makarcyzk; Guanghua Lei; Alexander Chang; Peter G. Alexander; Tingjun Hao; Anne-Marie Padget; Nuria de Pedro; Tsapekos Menelaos; Hang Lin (Science China Life Sciences, 2022)

Structure related α-glucosidase inhibitory activity and molecular docking analyses of phenolic compounds from Paeonia suffruticosa - Po-Chun Chen; Bongani Sicelo Dlamini; Chiy-Rong Chen; Yueh-Hsiung Kuo; Wen-Ling Shih; Yun-Sheng Lin; Chien-Hsing Lee; Chi-I Chang (Medicinal Chemistry Research, 2022)

Association of DNA methylation and transcriptome reveals epigenetic etiology of heart failure - Zhongxiao Lin; Jishuo Chang; Xinzhi Li; Jianglin Wang; Xiaodan Wu; Xiaoyan Liu; YiZhun Zhu; Xi-Yong Yu (Functional & Integrative Genomics, 2022)

Identification and Expression Analysis of miR160 and Their Target Genes in Cucumber - Yaoyao Li; Weirong Luo; Yongdong Sun; Huaicheng Chang; Kai Ma; Zhenxiang Zhao; Lin Lu (Biochemical Genetics, 2022)

An innovative targeted therapy for fluoroscopy-induced chronic radiation dermatitis - Kai-Che Wei; Shih-Fan Lai; Wei-Lun Huang; Kuo-Chung Yang; Ping-Chin Lai; Wan-Ju Wei; Tsung-Hsien Chang; Yun-Chen Huang; Ya-Chuan Tsai; Shin-Chih Lin; Sun-Jang Lin; Shih-Chieh Lin (Journal of Molecular Medicine, 2022)
Fluoroscopy-induced chronic radiation dermatitis (FICRD) is a complication of fluoroscopy-guided intervention. Unlike acute radiation dermatitis, FICRD is different as delayed onset and usually appears without preexisting acute dermatitis. Unfortunately, the chronic and progressive pathology of FICRD makes it difficult to treat, and some patients need to receive wide excision and reconstruction surgery. Due to lack of standard treatment, investigating underlying mechanism is needed in order to develop an effective therapy. Herein, the Hippo pathway is specifically identified using an RNA-seq analysis in mild damaged skin specimens of patients with FICRD. Furthermore, specific increase of the Yes-associated protein (YAP1), an effector of the Hippo pathway, in skin region with mild damage plays a protective role for keratinocytes via positively regulating the numerous downstream genes involved in different biological processes. Interestingly, irradiated-keratinocytes inhibit activation of fibroblasts under TGF-β1 treatment via remote control by an exosome containing YAP1. More importantly, targeting one of YAP1 downstream genes, nuclear receptor subfamily 3 group C member 1 (NR3C1), which encodes glucocorticoid receptor, has revealed its therapeutic potential to treat FICRD by inhibiting fibroblasts activation in vitro and preventing formation of radiation ulcers in a mouse model and in patients with FICRD. Taken together, this translational research demonstrates the critical role of YAP1 in FICRD and identification of a feasible, effective therapy for patients with FICRD. Key messages • YAP1 overexpression in skin specimens of radiation dermatitis from FICRD patient. • Radiation-induced YAP1 expression plays protective roles by promoting DNA damage repair and inhibiting fibrosis via remote control of exosomal YAP1. • YAP1 positively regulates NR3C1 which encodes glucocorticoid receptor expression. • Targeting glucocorticoid receptor by prednisolone has therapeutic potential for FICRD patient.

The difference in the intracellular Arg/Lys-rich and EHLVY motifs contributes to distinct subcellular distribution of HAI-1 versus HAI-2 - Nanxi Huang; Robert B. Barndt; Dajun D. Lu; Qiaochu Wang; Shih-Ming Huang; Jehng-Kang Wang; Ping-Ying Chang; Chao-Yang Chen; Je-Ming Hu; Hui-Chen Su; Michael D. Johnson; Chen-Yong Lin (Human Cell, 2022)

Analysis of Timing Effect on Flow Field and Pulsation in Vertical Axial Flow Pump - Fan Yang; Pengcheng Chang; Yao Yuan; Na Li; Rongsheng Xie; Xiaowen Zhang; Zhikang Lin (Journal of Marine Science and Engineering, 2021)
Vertical axial flow pump device has the characteristics of large flow and low head, which is widely used in pumping station projects with head of 3–9 m. In order to study the influence of the timing effect of the impeller relative flow channel and guide vane on the flow field and pulsation in the axial flow pump device, the whole flow channel of the vertical axial flow pump device was taken as the research object. The reliability of the numerical simulation was verified by physical model test. The flow field characteristics and pressure pulsation characteristics of the inlet and outlet regions of the impeller, the guide vane and the campaniform inlet conduit at different timing positions of the impeller under different flow rates were analyzed. The results show that the pressure coefficient distribution of the impeller inlet of the vertical axial flow pump device presents four high-pressure areas and four low-pressure areas with the rotation of the impeller. The pressure pulsation at the inlet and outlet of the impeller is mainly affected by the rotation of the impeller, and the main frequency is 4 times the rotation frequency amplitude of pressure pulsation decreases with the increase of flow rate. When the flow rate increased from 0.8 Qbep to 1.2 Qbep, the average velocity circulation at the guide vane outlet decreased by 12%; there is an obvious negative value region of the internal regularized helicity of the guide vane. When the flow rate increases from 0.8 Qbep to 1.2 Qbep, the amplitude of the pressure pulsation coefficient at the outlet of the guide vane decreases gradually, with a decrease of 94%. When the flow rate is 1.2 Qbep, the main frequency and the secondary frequency of the pressure pulsation are both low-frequency, with obvious low-frequency pulsation characteristics. Under the small flow condition of 0.8 Qbep, the outlet flow fluctuation of seven guide vane was 18.9% on average, and the flow variation of each guide vane was large. Under the optimal flow condition of 1.0 Qbep and large flow condition of 1.2 Qbep, the outlet flow fluctuation of 7 guide vane is 4.7% and 0.56% on average, and the flow change of each guide vane is stable. The outlet flow of the guide vane is mainly concentrated in two guide vane slots of the guide vane, and the flow ratios are 30.56%, 30.14% and 29.16% under three flow conditions, respectively. The research results provide a scientific basis for the optimization design and stable operation of vertical axial flow pump device.

Measuring Heterogeneity in 18F-Fluorodeoxyglucose Positron Emission Tomography Images for Classifying Metastatic and Benign Bone Lesions in Patients with Cervical Cancer - Feng-Yuan Liu; Gigin Lin; Jing-Ren Tseng; Angel Chao; Huei-Jean Huang; Hung-Hsueh Chou; Yu-Chen Chang; Tzu-Chen Yen; Chyong-Huey Lai (Journal of Medical and Biological Engineering, 2021)
Purpose Heterogeneity assessment can be applied for medical imaging analysis. Here, we evaluated first-order and texture analysis (TA) metrics in 18 F-fluorodeoxyglucose ( 18 F-FDG) positron emission tomography (PET) imaging for classification of metastatic and benign bone lesions in patients with cervical cancer. Methods The data of 18 F-FDG PET studies performed on a specific PET/CT system from 2016 to 2018 in patients with cervical cancer were retrieved. The data of bone lesions extracted from studies over 2016–2017 and 2018 were used as training and validation datasets, respectively. Metastatic bone lesions were identified in each dataset, with an equal number of benign bone lesions selected. Cuboid volume of interest (VOI) consisting of 3 × 3 × 5 reconstructed voxels was applied for first-order metrics, and cubic VOI consisting of smaller voxels with trilinear interpolation of standardized uptake value (SUV) was adopted for TA metrics. First-order metrics included the maximum SUV (SUVmax) of lesions and the mean voxel SUV and its standard deviation (SUVsd), skewness, and kurtosis in VOI. In total, 4464 TA metrics based on 62 texture features were evaluated. Logistic regression was used for classification with area under the receiver operating characteristic curve (AUC) as the performance measure. Results From the training and validation datasets, 98 and 42 metastatic bone lesions were identified, respectively. SUVsd demonstrated higher performance than did SUVmax in both the training (AUC .798 vs .732, P = .001) and validation (AUC .786 vs .684, P < .001) datasets. Top-performing TA metrics demonstrated significantly higher performance in the training dataset, but not in the validation dataset. Conclusion A simple first-order measure of heterogeneity, SUVsd, was found to be superior to SUVmax for the classification of metastatic and benign bone lesions. Multiple hypothesis testing can result in false-positive findings in TA with multiple features and parameters; careful validation is required.

Electrical Impedance Tomography Analysis Between Two Similar Respiratory System Compliance During Decremetal PEEP Titration in ARDS Patients - Po-Lan Su; Wei-Chieh Lin; Yen-Fen Ko; Kuo-Sung Cheng; Chang-Wen Chen (Journal of Medical and Biological Engineering, 2021)
Purpose The positive end-expiratory pressure (PEEP) level with best respiratory system compliance (Crs) is frequently used for PEEP selection in acute respiratory distress syndrome (ARDS) patients. On occasion, two similar best Crs (where the difference between the Crs of two PEEP levels is < 1 ml/cm H 2 O) may be identified during decremental PEEP titration. Selecting PEEP under such conditions is challenging. The aim of this study was to provide supplementary rationale for PEEP selection by assessing the global and regional ventilation distributions between two PEEP levels in this situation. Methods Eight ARDS cases with similar best Crs at two different PEEP levels were analyzed using examination-specific electrical impedance tomography (EIT) measures and airway stress index (SIaw). Five Crs were measured at PEEP values of 25 cm H 2 O (PEEP 25 ), 20 cm H 2 O (PEEP 20 ), 15 cm H 2 O (PEEP H ), 11 cm H 2 O (PEEP I ), and 7 cm H 2 O (PEEP L ). The higher PEEP value of the two PEEPs with similar best Crs was designated as PEEP upper , while the lower designated as PEEP lower . Results PEEP H and PEEP I shared the best Crs in two cases, while similar Crs was found at PEEP I and PEEP L in the remaining six cases. SIaw was higher with PEEP upper as compared to PEEP lower (1.06 ± 0.10 versus 0.99 ± 0.09, p = 0.05). Proportion of lung hyperdistension was significantly higher with PEEP upper than PEEP lower (7.0 ± 5.1% versus 0.3 ± 0.5%, p = 0.0002). In contrast, proportion of recruitable lung collapse was higher with PEEP lower than PEEP upper (18.6 ± 4.4% versus 5.9 ± 3.7%, p < 0.0001). Cyclic alveolar collapse and reopening during tidal breathing was higher at PEEP lower than PEEP upper (34.4 ± 19.3% versus 16.0 ± 9.1%, p = 0.046). The intratidal gas distribution (ITV) index was also significantly higher at PEEP lower than PEEP upper (2.6 ± 1.3 versus 1.8 ± 0.7, p = 0.042). Conclusions PEEP upper is a rational selection in ARDS cases with two similar best Crs. EIT provides additional information for the selection of PEEP in such circumstances.

Association between exposure to road traffic noise and hearing impairment: a case-control study - Tang-Chuan Wang; Ta-Yuan Chang; Richard S. Tyler; Bing-Fang Hwang; Yi-Hung Chen; Che-Ming Wu; Chiu-Shong Liu; Kuang-Chao Chen; Chia-Der Lin; Ming-Hsui Tsai (Journal of Environmental Health Science and Engineering, 2021)

Timing and magnitude of climatic extremes differentially elevate mortality but enhance recovery in a fish population - Ming‐Chih Chiu; Shih‐Hsun Chang; Yu‐Ting Yen; Lin‐Yan Liao; Hsing‐Juh Lin (Global Change Biology, 2021)
The countervailing effects of disturbances (e.g., high mortality and enhanced recovery) on population dynamics can occur through demographic processes under rapidly increasing climatic extremes. Across an extreme‐event gradient, we mechanistically demonstrated how dramatic changes in streamflow have affected the population persistence of endangered salmon in monsoonal Taiwan over a three‐decade period. Our modeling indicated that the dynamics of the age‐structured population were attributed to demographic processes, in which extensive mortality was characterized as a function of climatic extremes and vulnerability in the young stage of fish. In the stochastic simulations, we found that the extensive mortality and high proportion of large fish resulted from extreme flooding, which caused high values of postimpact population recovery. Our empirical evidence suggests that the magnitudes and timing of disturbance can explain the population persistence when facing climatic extremes and thereby challenges the understanding of the mechanistic drivers of these countervailing phenomena under changing environmental conditions.

Conservation planning on China's borders with Myanmar, Laos, and Vietnam - Lin Wang; Bin Yang; Yang Bai; Xiaoqiang Lu; Richard T. Corlett; Yunhong Tan; Xiao‐Yong Chen; Jianguo Zhu; Yan Liu; Rui‐Chang Quan (Conservation Biology, 2021)
Transboundary conservation is playing an increasingly important role in maintaining ecosystem integrity and halting biodiversity loss caused by anthropogenic activities. However, lack of information on species distributions in transboundary regions and understanding of the threats in these areas impairs conservation. We developed a spatial conservation plan for the transboundary areas between Yunnan province, southwestern China, and neighboring Myanmar, Laos, and Vietnam in the Indo‐Burma biodiversity hotspot. To identify priority areas for conservation and restoration, we determined species distribution patterns and recent land‐use changes and examined the spatiotemporal dynamics of the connected natural forest, which supports most species. We assessed connectivity with equivalent connected area (ECA), which is the amount of reachable habitat for a species. An ECA incorporates the presence of habitat in a patch and the amount of habitat in other patches within dispersal distance. We analyzed 197,845 locality records from specimen collections and monographs for 21,004 plant and vertebrate species. The region of Yunnan immediately adjacent to the international borders had the highest species richness, with 61% of recorded species and 56% of threatened vertebrates, which suggests high conservation value. Satellite imagery showed the area of natural forest in the border zone declined by 5.2% (13,255 km 2 ) from 1995 to 2018 and monoculture plantations increased 92.4%, shrubland 10.1%, and other cropland 6.2%. The resulting decline in connected natural forest reduced the amount of habitat, especially for forest specialists with limited dispersal abilities. The most severe decline in connectivity was along the Sino‐Vietnamese border. Many priority areas straddle international boundaries, indicating demand and potential for establishing transboundary protected areas. Our results illustrate the importance of bi‐ and multilateral cooperation to protect biodiversity in this region and provide guidance for future conservation planning and practice.

Streptococcus vaginalis sp. nov., a novel bacterial species isolated from vaginal swabs of a pregnant woman with diabetes - An-Shine Chao; Chiao-Yun Lin; Angel Chao; Yun-Shien Lee; Yu-Chung Chang; Hui-Chung Wu; Yu-Jie Dai; Wei-Qi Liao; Fan-Ching Kao; Yi-Sheng Chen (Archives of Microbiology, 2021)

Wave-ice dynamical interaction: a numerical model and its application - Yang Zhang; Changsheng Chen; Guoping Gao; Jianhua Qi; Huichan Lin; Wei Yu; Liang Chang (Acta Oceanologica Sinica, 2021)

A new abietane diterpene and anti-complementary constituents from Juniperus tibetica - Dong-Lin Zeng; Chang-Yue Wang; Hui-Qin Gao; Dao-Feng Chen; Yan Lu (Natural Product Research, 2021)

Two new cephalochromin derivative from the Alternaria sp. ZG22 - Xin-Ming Song; Xue-Ming Zhou; Ya-Ling Li; Li-Bing Huang; Cai-Cui Chen; Yan Gao; Lin He; Xiao-qun Mao; Bing Chen; Jing-Wen Liu; Hui-Jie Liu; Xiao-Ping Song; et al. (Natural Product Research, 2021)

Dynamics Simulation of Grasping Process of Underwater Vehicle-Manipulator System - Zongyu Chang; Yang Zhang; Zhongqiang Zheng; Lin Zhao; Kunfan Shen (Journal of Marine Science and Engineering, 2021)
Underwater vehicle-manipulator system (UVMS) can be applied to fulfill different complex underwater tasks such as grasping, drilling, sampling, etc. It is widely used in the field of oceanographic research, marine exploration, military, and commercial applications. In this paper, the dynamic simulation of UVMS is presented in the process of grasping an object. First, the dynamic model of UVMS, which considers the change of the load of manipulator when the end effector of manipulator grasps the object, is developed. To compare different conditions, numerical simulation of grasping processes without/with vehicle attitude control are carried out. The simulation results show that the coupling dynamics between the vehicle and the manipulator in the grasping process are clearly illustrated. It deteriorates the positioning accuracy of the end effector of the manipulator and is harmful to underwater precision operations. The tracking position error of end effector without vehicle control is large and UVMS cannot complete the grasping task under this condition. Vehicle control can compensate the motion of the vehicle due to the coupling effect caused by the motion of the manipulator. This study will contribute to underwater operation mission for UVMS with floating base.

Ambient climate determines the directional trend of community stability under warming and grazing - Peipei Liu; Wangwang Lv; Jianping Sun; Caiyun Luo; Zhenhua Zhang; Xiaoxue Zhu; Xingwu Lin; Jichuang Duan; Guangping Xu; Xiaofeng Chang; Yigang Hu; Qiaoyan Lin; et al. (Global Change Biology, 2021)
Changes in ecological processes over time in ambient treatments are often larger than the responses to manipulative treatments in climate change experiments. However, the impacts of human‐driven environmental changes on the stability of natural grasslands have been typically assessed by comparing differences between manipulative plots and reference plots. Little is known about whether or how ambient climate regulates the effects of manipulative treatments and their underlying mechanisms. We collected two datasets, one a 36‐year long‐term observational dataset from 1983 to 2018, and the other a 10‐year manipulative asymmetric warming and grazing experiment using infrared heaters with moderate grazing from 2006 to 2015 in an alpine meadow on the Tibetan Plateau. The 36‐year observational dataset shows that there was a nonlinear response of community stability to ambient temperature with a positive relationship between them due to an increase in ambient temperature in the first 25 years and then a decrease in ambient temperature thereafter. Warming and grazing decreased community stability with experiment duration through an increase in legume cover and a decrease in species asynchrony, which was due to the decreasing background temperature through time during the 10‐year experiment period. Moreover, the temperature sensitivity of community stability was higher under the ambient treatment than under the manipulative treatments. Therefore, our results suggested that ambient climate may control the directional trend of community stability while manipulative treatments may determine the temperature sensitivity of the response of community stability to climate relative to the ambient treatment. Our study emphasizes the importance of the context dependency of the response of community stability to human‐driven environmental changes.

Image Segmentation in 3D Brachytherapy Using Convolutional LSTM - Jui-Hung Chang; Kai-Hsiang Lin; Ti-Hao Wang; Yu-Kai Zhou; Pau-Choo Chung (Journal of Medical and Biological Engineering, 2021)

Skvortzovia yunnanensis, a new species of corticioid fungus from southern China - Jun-Hong Dong; Xiao He; Chang-Lin Zhao (Kew Bulletin, 2021)

Applying Artificial Intelligence (AI) Techniques to Implement a Practical Smart Cage Aquaculture Management System - Chung-Cheng Chang; Jung-Hua Wang; Jenq-Lang Wu; Yi-Zeng Hsieh; Tzong-Dar Wu; Shyi-Chy Cheng; Chin-Chun Chang; Jih-Gau Juang; Chyng-Hwa Liou; Te-Hua Hsu; Yii-Shing Huang; Cheng-Ting Huang; et al. (Journal of Medical and Biological Engineering, 2021)
Purpose This paper presents our team’s results to establish an AIoT smart cage culture management system. Methods According to the built system, the farmed field information is transmitted to the data platform of Ocean Cloud, and all collected data and analysis results can be applied to the cage culture field after the bigdata analysis. Results This management system successfully integrates AI and IoT technologies and is applied in cage culture. Using underwater biological analysis images and AI feeding as examples, this paper explains how the system integrates AI and IoT into a feasible framework that can constantly acquire information about the health status of fish, survival rate of fish, as well as the feed residuals. Conclusion The results of our research enable the aquaculture operators or owners to efficiently reduce the feed residual, monitor the growth of fish, and increase fish survival rate, thereby increasing the feed conversion rate.

Bioaccumulation and translocation of trace elements in soil-irrigation water-wheat in arid agricultural areas of Xin Jiang, China - Muyesaier Tudi; Huada Daniel Ruan; Yunjiang Yu; Li Wang; Binggan Wei; Shuangmei Tong; Chang Kong; Lin-sheng Yang (Ecotoxicology, 2021)

An eco‐city design methodology for hilly areas of western China - Kai Lin; Zhengwei He; Zhujun Zhao; Jiaxin Chang; Keran Tang; Rui Qu; Li He (Earth Science Informatics, 2021)

Future variation in mountainous discharge in arid northwestern China: A basin case study - Lei Wu; Chang-bin Li; Xu-hong Xie; Jia-nan Lv; Jian-mei Wei; Xuan Zhou; Lin-shan Yang (Journal of Mountain Science, 2021)

Shear behaviors of clay-infilled joint with different water contents: experiment and model - Yanlin Zhao; Yang Li; Le Chang; Yixian Wang; Hang Lin (Arabian Journal of Geosciences, 2021)

New ent -kauran diterpene and antioxidant components from the seed of Ipomoea nil - Chia-Lin Lee; Pei-Ting Lo; Yun-Lian Jhan; Chao-Jung Chen; Yuan-Shiun Chang (Natural Product Research, 2021)

A Causal Role of the Cerebellum in Auditory Feedback Control of Vocal Production - Danhua Peng; Qing Lin; Yichen Chang; Jeffery A. Jones; Guoqing Jia; Xi Chen; Peng Liu; Hanjun Liu (The Cerebellum, 2021)

The relationship between anthocyanin accumulation and photoprotection in young leaves of two dominant tree species in subtropical forests in different seasons - Zheng-Chao Yu; Wei Lin; Xiao-Ting Zheng; Wah Soon Chow; Yan-Na Luo; Min-Ling Cai; Chang-Lian Peng (Photosynthesis Research, 2021)

The major photoprotective role of anthocyanins in leaves of Arabidopsis thaliana under long-term high light treatment: antioxidant or light attenuator? - Xiao-Ting Zheng; Zheng-Chao Yu; Jun-Wei Tang; Min-Ling Cai; Yi-Lin Chen; Cheng-Wei Yang; Wah Soon Chow; Chang-Lian Peng (Photosynthesis Research, 2021)

Photosynthetic compensation of non-leaf organ stems of the invasive species Sphagneticola trilobata (L.) Pruski at low temperature - Min-ling Cai; Wen-qiao Ding; Jun-jie Zhai; Xiao-ting Zheng; Zheng-chao Yu; Qi-lei Zhang; Xiao-hua Lin; Wah Soon Chow; Chang-lian Peng (Photosynthesis Research, 2021)

Conversion of rice husk into fermentable sugar and silica using acid-catalyzed ionic liquid pretreatment - YuJie Wang; Jing-yong Liu; Jian Sun; Sumarlin Shangdiar; Kassian T.T. Amesho; Yung-Chang Lin; Yen-Ping Peng; Ken-Lin Chang (Environmental Science and Pollution Research, 2021)

Gas-phase isopropanol degradation by nonthermal plasma combined with Mn-Cu/-Al2O3 - Ken-Lin Chang; Yu-Chieh Lin; Ming-Ze Qiu; Chun-Wei Tu; Chih-Ping Chang; Jhong-Lin Wu; Yung-Chang Lin; Chien-Kuei Chang (Environmental Science and Pollution Research, 2021)

Recycle of synthetic calcium fluoride and waste sulfuric acid to produce electronic grade hydrofluoric acid - Min-Fa Lin; Jhong-Lin Wu; Ken-Lin Chang; Wen-Jhy Lee; Chih-Ping Chang; Yung-Chang Lin; Po-Han Chen (Environmental Science and Pollution Research, 2021)

Glabridin attenuates atopic dermatitis progression through downregulating the TLR4/MyD88/NF-κB signaling pathway - Jing Chang; Lin Wang; Minna Zhang; Zengjiao Lai (Genes & Genomics, 2021)

Geographic and subsequent biotic isolations led to a diversity anomaly of section Heterotropa (genus Asarum : Aristolochiaceae) in insular versus continental regions of the Sino‐Japanese Floristic Region - Daiki Takahashi; Shota Sakaguchi; Yu Feng; Yuji Isagi; Ying‐Xiong Qiu; Pan Li; Rui‐Sen Lu; Chang‐Tse Lu; Shih‐Wen Chung; Yang‐Shan Lin; Yun‐Chao Chen; Atsushi J. Nagano; et al. (Journal of Biogeography, 2021)
Aim The Sino‐Japanese Floristic Region has extremely high species diversity with respect to temperate plants; however, the reasons for this diversity are poorly understood because most studies have only considered geographic isolation caused by climatic oscillations. In some plant groups, high floral trait diversity and uneven species diversity between insular systems and the continental area suggest other factors may have important roles too. The primary purpose of this study is to reveal how abiotic and biotic factors have shaped the species diversity anomaly of Heterotropa between the insular systems and the continental area. Location The Sino‐Japanese Floristic Region. Taxon Section Heterotropa (genus Asarum ; Aristolochiaceae). Methods Using ddRAD‐seq and chloroplast genome data, we built a time‐calibrated phylogenetic tree including 79 species. We estimated the patterns of floral traits (flowering time and floral size) evolution using macroevolutionary modelling, and tested the correlation of speciation rate with the trait evolution rates. Finally, we estimated the isolation factors of all taxa pairs and sister‐taxa pairs based on distribution range and floral traits. Results Phylogenetic analysis indicated that Heterotropa was diverged into two clades (continental clade and insular clade) in the Miocene, and the major subclades corresponded to geographic entities. Most rate shifts accelerating floral trait's evolution occurred during the Pleistocene period. Evolution rate of floral traits showed positive correlation with the speciation rate. Large proportion of taxa in the insular clade are distributed allopatrically. Several sister pairs showed floral trait divergence with geographic overlap. Main Conclusions The diversification of Heterotropa appears to have been triggered by geographic and climatic events, and subsequent repeated floral trait evolution with and without geographic isolation. Furthermore, the high species diversity in the insular systems would have been formed by the repeated range fragmentations and contractions. Our study demonstrates the importance of multidimensional studies to understand the diversification process of temperate plants in the Sino‐Japanese Floristic Region.

Exploring the environmental and economic potential for biogas production from swine manure wastewater by life cycle assessment - Meng-Fen Shih; Chyi-How Lay; Chiu-Yue Lin; Shen-Ho Chang (Clean Technologies and Environmental Policy, 2021)

The mechanism and application of high-pressure water jet technology to prevent compound dynamic disaster - Zeng-qiang Yang; Chang Liu; Feng-shuo Li; Lin-ming Dou; Gang-wei Li; Da-wei Wang (Arabian Journal of Geosciences, 2021)

Characterization Of Secondary Metabolites From The Rhizome Of Cynara Scolymus And Their Antioxidant Properties - Chia-Lin Lee; Kuo-Chen Liao; Chien-Chih Chen; Yen-An Lin; Tung-Ying Wu; Yun-Lian Jhan; Chao-Jung Chen; Juan-Cheng Yang; Yang-Chang Wu (Natural Product Research, 2021)

Determination of Similarity Cutoff Value for the Classification of Macrobenthic Communities in the Korean Coast - Jae-Won Yoo; Chae-Lin Lee; Sungtae Kim; Su-Young Jeong; Chang-Gun Lee; Byoung-Seol Koh; Sang-Ock Ryu (Ocean Science Journal, 2021)

Molecular Imaging for Radiolabeling a PSMA-Targeted Long Circulating Peptide as a Theranostic Agent in Mice Bearing a Human Prostate Tumor - Ming-Hsin Li; Sheng-Nan Lo; Ming-Wei Chen; Wei-Lin Lo; Yuan-Ruei Huang; Shih-Ying Lee; Su-Jung Chen; Shih-Wei Lo; Shih-Ming Wang; Chih-Hsien Chang (Journal of Medical and Biological Engineering, 2021)

Safety and efficacy of new oral anticoagulants compared to those of warfarin in AF patients with cancer: a meta-analysis of randomized clinical trials and observational studies - Yueming Chen; Min Mao; Jing Chang; Jing Yan; Tiantian Yang; Yang Liu; Meng Luo; Yuhao Hu; Qi Yang; Lin Zhou; Kanghua Ma (European Journal of Clinical Pharmacology, 2021)

A dye combination for the staining of pollen coat and pollen wall - Xin-Lei Jia; Jing-Shi Xue; Fang Zhang; Chi Yao; Shi-Yi Shen; Chang-Xu Sui; Yu-Jia Peng; Qin-Lin Xu; Yi-Feng Feng; Wen-Jing Hu; Ping Xu; Zhong-Nan Yang (Plant Reproduction, 2021)

Modelling plant canopy effects on water-heat exchange in the freezing-thawing processes of active layer on the Qinghai-Tibet Plateau - Lin-mao Guo; Juan Chang; Hong-liang Xu; Wen-jun Sun (Journal of Mountain Science, 2021)

Ghrelin Affects Gastric Cancer Progression by Activating AMPK Signaling Pathway - Xiao-Lin Hu; Yong-Jun Zhu; Chang-Hua Hu; Li You; Juan Wu; Xiao-Yan He; Wen-Jie Huang; Zong-Hui Wu (Biochemical Genetics, 2021)

First report of cucurbit chlorotic yellows virus infecting melon, watermelon and wild melon in the Philippines - Hsin-Yi Chang; Li-Cheng Chen; Chung-Cheng Lin; Wen-Shi Tsai (Journal of Plant Pathology, 2021)

Influence of different fluidization and gasification parameters on syngas composition and heavy metal retention in a two-stage fluidized bed gasification process - Jia-Hong Kuo; Chiou-Liang Lin; Chang-Yu Ho; Jia-Chi Hung (Environmental Science and Pollution Research, 2021)

Effect of loading rate on the nonlinear elastic response of concrete - Xinyu Wang; Lin Song; Xicai Gao; Xu Chang (European Journal of Environmental and Civil Engineering, 2021)

Triaxial Compression Testing at Constant and Reducing Confining Pressure for the Mechanical Characterization of a Specific Type of Sandstone - Jiu-chang Zhang; Zhi-nan Lin; Bo Dong; Rong-xin Guo (Rock Mechanics and Rock Engineering, 2021)

Evidence-based Customized Ankle-Foot Orthosis with Energy Storage - Chih-Chun Lin; Chien-Hsien Yeh; Yi-Chun Tsai; Li-Chieh Kuo; Hsiu-Yun Hsu; Ping-Han Chuang; Kai Chang; Fong-Chin Su (Journal of Medical and Biological Engineering, 2021)

Molecular mechanism underlying Pyropia haitanensis PhHsp22-mediated increase in the high-temperature tolerance of Chlamydomonas reinhardtii - Jing Chang; Jianzhi Shi; Jianzhang Lin; Dehua Ji; Yan Xu; Changsheng Chen; Wenlei Wang; Chaotian Xie (Journal of Applied Phycology, 2021)
Global warming is one of the key limiting factors affecting the cultivation of Pyropia haitanensis which is an economically important macroalgae species grown in southern China. However, the mechanism underlying the high-temperature tolerance of P. haitanensis remains largely unknown. In a previous study, we showed that the expression of the small heat shock protein 22 gene ( Hsp22 ) is upregulated in P. haitanensis in response to high-temperature stress, but the associated regulatory mechanism was not fully elucidated. In this study, a transgenic Chlamydomonas reinhardtii expression system was used to functionally characterize P. haitanensis Hsp22 . Our analyses indicated that the C-terminal of PhHsp22 is highly conserved and contains an A-crystal structure domain. A phylogenetic analysis revealed PhHsp22 is not closely related to small heat shock protein genes in other species. Additionally, PhHsp22 expression significantly increased at 3 and 6 h after initiating 33 °C treatment, which improved the survival rate of transgenic C. reinhardtii during the early stage of high-temperature treatment. The further transcriptome analysis revealed that PhHsp22 expression can promote pathways related to energy metabolism, metabolites metabolism, and protein homeostasis in transgenic C. reinhardtii cells exposed to high temperatures. Therefore, PhHsp22 may be crucial for the response of Pyropia species to high-temperature stress. Furthermore, this gene may be useful for breeding new high-temperature algal strains.

Effects of plant growth regulators and polyamines on bract longevity in Bougainvillea buttiana - Kuan-Hung Lin; Jui-Mei Li; Chun-Wei Wu; Yu-Sen Chang (Horticulture, Environment, and Biotechnology, 2021)

The relationship between ambient temperature and acute respiratory and cardiovascular diseases in Shenyang, China - Yang Shen; Xudong Zhang; Cai Chen; Qianqian Lin; Xiyuan Li; Wenxiu Qu; Xuejian Liu; Li Zhao; Shijie Chang (Environmental Science and Pollution Research, 2021)

Establishment of a comprehensive analysis method for the microfaunal movement in activated sludge - Xiaobing Hu; Kun Wang; Jing Chang; Lin Zhang; Meiying Zhong; Yong Nie (Environmental Science and Pollution Research, 2021)

Azure-winged Magpies Cyanopica cyanus passed the tasks on the Uzgiris-Hunt scale of object permanence - Lin Wang; Yunchao Luo; Abudusaimaiti Maierdiyali; Hao Chang; Sana Ullah; Zhongqiu Li (Journal of Ornithology, 2021)

New secondary metabolite with cytotoxicity from spawning soft coral Asterospicularia laurae in Taiwan - Jui-Hsin Su; Chih-I Liu; Mei-Chin Lu; Chi-I Chang; Min-Ying Hsieh; Yu-Chi Lin; Chang-Feng Dai; Ya-Han Zhang; Zheng-Yu Lin; Yun-Sheng Lin (Natural Product Research, 2021)

Microbiome Reengineering by Heat Selection for Rapid Biodegradation of Trichloroethylene with Minimal Vinyl Chloride Formation - Ai-Lin Chan; Chien-Yun Tseng; Tzu-Wen Chen; Yi-Hsuan Lo; Shu-Chi Chang (Water, Air, & Soil Pollution, 2021)

Biomimetic Au nanodot synthesis using Escherichia coli secretion and interaction with α-ketoglutaric acid - Xiaoxiao Xie; Xiaoli Yang; Yi Chang; Xiangli Ru; Xiaoming Ma; Lin Yang (Science China Life Sciences, 2021)

Shallow gas hydrates off southwest Taiwan and their mechanisms - Yin-Sheng Huang; Shu-Kun Hsu; Chih-Chieh Su; Andrew Tien-Shun Lin; Pai-Sen Yu; Nathalie Babonneau; Gueorgui Ratzov; Serge Lallemand; Pi-Chuen Huang; Shiao-Shan Lin; Jing-Yi Lin; Kuo-Yen Wei; et al. (Marine Geophysical Research, 2021)
We have collected two shallow gas hydrate samples at two sites having different geological settings off southwest Taiwan during the cruise MD214 in 2018. The first core site, MD18-3542, is on the South Yuan-An East Ridge at ~ 1200 m water deep, where a structural unconformity covered by fine-silt sediments appears at ~ 5.5 m below the seafloor. The second core site, MD18-3543, is close to the Good-Weather Ridge at ~ 1100 m water deep, where a gas-related pockmark structure and authigenic carbonates are present at shallow strata with fine-silt sediments near the seafloor. Sediment properties of core MD18-3542 are distinctively different above and below the layer corresponding to the unconformity. Both cores show obvious gaps or voids in the lower core halves. The core features could be linked to the dissociated methane upward migrating from deep strata. Core site settings with upwelling methane would favor the formation of shallow gas hydrates. At site MD18-3542, the shallow hydrate could be formed due to high concentration methane kept beneath the unconformity covered by fine-silt sediments. At site MD18-3543, the shallow hydrate could be formed due to an extremely high flux of upwelling methane trapped either beneath the authigenic carbonates or fine-silt sediments.

Delayed association of acute particulate matter 2.5 air pollution exposure with loss of complexity in cardiac rhythm dynamics: insight from detrended fluctuation analysis - Tsung-Ying Tsai; Li-Wei Lo; Shin-Huei Liu; Wen-Han Cheng; Yu-Hui Chou; Wei-Lun Lin; Yenn-Jiang Lin; Shih-Lin Chang; Yu-Feng Hu; Fa-Po Chung; Jo-Nan Liao; Tze-Fan Chao; et al. (Environmental Science and Pollution Research, 2021)

Lentibacillus saliphilus. sp. nov., a moderately halophilic bacterium isolated from a saltern in Korea - Yun Wang; Gang-Qiang Jiang; Hong-Ping Lin; Peng Sun; Hong-Yan Zhang; Dong-Mei Lu; Li-Yun Wang; Chang-Jin Kim; Shu-Kun Tang (Archives of Microbiology, 2021)

Projections from Infralimbic Cortex to Paraventricular Thalamus Mediate Fear Extinction Retrieval - Yan Tao; Cheng-Yun Cai; Jia-Yun Xian; Xiao-Lin Kou; Yu-Hui Lin; Cheng Qin; Hai-Yin Wu; Lei Chang; Chun-Xia Luo; Dong-Ya Zhu (Neuroscience Bulletin, 2021)

Ecological and health risk assessment of trace elements in surface soil in an arid region of Xin Jiang, China - Muyesaier Tudi; Huada Daniel Ruan; Binggan Wei; Li Wang; Shuangmei Tong; Chang Kong; Lin-sheng Yang (Journal of Soils and Sediments, 2021)

NLRP3 inflammasome priming and activation in cholestatic liver injury via the sphingosine 1-phosphate/S1P receptor 2/Gα(12/13)/MAPK signaling pathway - Lei Hou; Zhi Zhang; Le Yang; Na Chang; Xinhao Zhao; Xuan Zhou; Lin Yang; Liying Li (Journal of Molecular Medicine, 2021)

Dapagliflozin suppresses ER stress and protects doxorubicin-induced cardiotoxicity in breast cancer patients - Wei-Ting Chang; Yu-Wen Lin; Chung-Han Ho; Zhih-Cherng Chen; Ping-Yen Liu; Jhih-Yuan Shih (Archives of Toxicology, 2021)

The substrate‐dependent regulatory effects of the AfeI /R system in Acidithiobacillus ferrooxidans reveals the novel regulation strategy of quorum sensing in acidophiles - Xue‐Yan Gao; Chang‐Ai Fu; Likai Hao; Xiu‐Feng Gu; Rui Wang; Jian‐Qiang Lin; Xiang‐Mei Liu; Xin Pang; Cheng‐Jia Zhang; Jian‐Qun Lin; Lin‐Xu Chen (Environmental Microbiology, 2021)
Summary A LuxI/R‐like quorum sensing (QS) system (AfeI/R) has been reported in the acidophilic and chemoautotrophic Acidithiobacillus spp. However, the function of AfeI/R remains unclear because of the difficulties in the genetic manipulation of these bacteria. Here, we constructed different afeI mutants of the sulfur‐ and iron‐oxidizer A . ferrooxidans , identified the N‐acyl homoserine lactones (acyl‐HSLs) synthesized by AfeI, and determined the regulatory effects of AfeI/R on genes expression, extracellular polymeric substance synthesis, energy metabolism, cell growth and population density of A . ferrooxidans in different energy substrates. Acyl‐HSLs‐mediated distinct regulation strategies were employed to influence bacterial metabolism and cell growth of A . ferrooxidans cultivated in either sulfur or ferrous iron. Based on these findings, an energy‐substrate‐dependent regulation mode of AfeI/R in A . ferrooxidans was illuminated that AfeI/R could produce different types of acyl‐HSLs and employ specific acyl‐HSLs to regulate specific genes in response to different energy substrates. The discovery of the AfeI/R‐mediated substrate‐dependent regulatory mode expands our knowledge on the function of QS system in the chemoautotrophic sulfur‐ and ferrous iron‐oxidizing bacteria, and provides new insights in understanding energy metabolism modulation, population control, bacteria‐driven bioleaching process, and the coevolution between the acidophiles and their acidic habitats.

Suppression of phosphorus release from sediment using lanthanum carbonate as amendment - Yanhui Zhan; Mingyue Chang; Jianwei Lin (Environmental Science and Pollution Research, 2021)

Artificial Neural Network-based prediction of glacial debris flows in the ParlungZangbo Basin, southeastern Tibetan Plateau, China - Wang Tang; Hai-tao Ding; Ning-sheng Chen; Shang-Chang Ma; Li-hong Liu; Kang-lin Wu; Shu-feng Tian (Journal of Mountain Science, 2021)

Concurrent increases in post-pacing action potential duration and contractility predict occurrence of ventricular arrhythmia - Chih-Min Liu; Feng-Zhi Lin; Yao-Chang Chen; Yung-Kuo Lin; Yen-Yu Lu; Cheng-I Wu; Satoshi Higa; Shih-Ann Chen; Yi-Jen Chen (Pflügers Archiv - European Journal of Physiology, 2020)

Unraveling neuroHIV in the Presence of Substance Use Disorders - Yu Lin; Johnny J. He; Roger Sorensen; Linda Chang (Journal of Neuroimmune Pharmacology, 2020)

Improving Image Correlation and Differentiation of 3D Endoluminal Lesions in the Air Spaces Using a Novel Target Gray Level Mapping Technique: A Preliminary Study of Its Application to Computed Tomographic Colonography and Comparison with Traditional Surface Rendering Method - Lih-Shyang Chen; Ta-Wen Hsu; Shao-Jer Chen; Shu-Han Chang; Chih-Wen Lin; Yu-Ruei Chen; Chin-Chiang Hsieh; Shu-Chen Han; Ku-Yaw Chang; Chun-Ju Hou (Journal of Medical and Biological Engineering, 2020)

Correction to: 4-Phenylbutyric acid protects against vasculitic peripheral neuropathy induced by ischaemia–reperfusion through attenuating endoplasmic reticulum stress - Cay‑Huyen Chen; Ping‑Chen Shih; Han‑Yu Lin; Po‑Kai Wang; Po‑Ting Pan; Ching‑Wei Chuang; Ming‑Chang Kao (Inflammopharmacology, 2020)

Differential time-lag effects of ambient PM2.5 and PM2.5-bound PAHs on asthma emergency department visits - Shih-Chang Hsu; Jer-Hwa Chang; Chon-Lin Lee; Wen-Cheng Huang; Yuan-Pin Hsu; Chung-Te Liu; Shio-Shin Jean; Shau-Ku Huang; Chin-Wang Hsu (Environmental Science and Pollution Research, 2020)

Using sowing date management to promote micronutrient quality and alleviate cadmium accumulation in rice grains - Lin-lin Shi; Ming-xing Shen; Hong-jun Wu; Chang-ying Lu; Li-juan Mei; Xin-lian Zhu; Hai-hou Wang; Yun-Sheng Song (Cereal Research Communications, 2020)

Functional human brain connectivity during labor and its alteration under epidural analgesia - Fan-Pei Yang; An-Shine Chao; Sung-Han Lin; Anne Chao; Tzu-Hao Wang; Yao-Lung Chang; Hong-Shiu Chang; Jiun-Jie Wang (Brain Imaging and Behavior, 2020)

Boys with autism spectrum disorder have distinct cortical folding patterns underpinning impaired self-regulation: a surface-based morphometry study - Hsing-Chang Ni; Hsiang-Yuan Lin; Yu-Chieh Chen; Wen-Yih Isaac Tseng; Susan Shur-Fen Gau (Brain Imaging and Behavior, 2020)

Overexpression of a multifunctional β-glucosidase gene from thermophilic archaeon Sulfolobus solfataricus in transgenic tobacco could facilitate glucose release and its use as a reporter - Chih-Hao Huang; Tzu-Ling Huang; Yu-Chang Liu; Ting-Chieh Chen; Shih-Ming Lin; Shyh-Yu Shaw; Ching-Chun Chang (Transgenic Research, 2020)

Comparative performance assessment of landslide susceptibility models with presence-only, presence-absence, and pseudo-absence data - Dong-mei Zhao; Yuan-mei Jiao; Jin-liang Wang; Yin-ping Ding; Zhi-lin Liu; Cheng-jing Liu; Ying-mei Qiu; Juan Zhang; Qiu-e Xu; Chang-run Wu (Journal of Mountain Science, 2020)

Nuclear Factor-κB Pathway Mediates the Molecular Pathogenesis of LMNA-Related Muscular Dystrophies - Yanbin Fan; Dandan Tan; Xu Zhang; Danyu Song; Xingzhi Chang; Shuang Wang; Hui Yan; Lin Ge; Haipo Yang; Carsten Bönnemann; Jingying Liu; Suxia Wang; et al. (Biochemical Genetics, 2020)

Crack coalescence patterns and local strain behaviors near flaw tip for rock-like material containing two flaws subjected to biaxial compression - Yanlin Zhao; Jian Liao; Yixian Wang; Qiang Liu; Hang Lin; Le Chang (Arabian Journal of Geosciences, 2020)

Feeding Habits of Bigeye Tuna (Thunnus obesus) in the Western Indian Ocean Reveal a Size-Related Shift in Its Fine-Scale Piscivorous Diet - Chien-Hsiang Lin; Jing-Siang Lin; Kuo-Shu Chen; Meng-Hsien Chen; Chiee-Young Chen; Chih-Wei Chang (Frontiers in Marine Science, 2020)

Two new sesquiterpenoid glycosides from the stems of Zanthoxylum armatum DC - Ya-Lin Liu; Liang-Liang Gao; Tong-Tong Song; Tao Guo; Jun Chang (Natural Product Research, 2020)

Optimizing the MIC breakpoints of amoxicillin and tetracycline for antibiotic selection in the rescue therapy of H. pylori with bismuth quadruple regimen - Ming-Tsung Hsieh; Wei-Lun Chang; Chung-Tai Wu; Hsiao-Bai Yang; Hsin-Yu Kuo; Meng-Ying Lin; Hsiu-Chi Cheng; Yu-Chin Tsai; Bor-Shyang Sheu (European Journal of Clinical Pharmacology, 2020)

Arthrobacter sedimenti sp. nov., isolated from river sediment in Yuantouzhu park, China - Pei Lin; Zheng-Fei Yan; Chang-Tian Li (Archives of Microbiology, 2020)

Erratum to: An Examination of the Predictability of Tropical Cyclone Genesis in High-Resolution Coupled Models with Dynamically Downscaled Coupled Data Assimilation Initialization - Mingkui Li; Shaoqing Zhang; Lixin Wu; Xiaopei Lin; Ping Chang; Gohkan Danabasoglu; Zhiqiang Wei; Xiaolin Yu; Huiqin Hu; Xiaohui Ma; Weiwei Ma; Haoran Zhao; et al. (Advances in Atmospheric Sciences, 2020)

Multi-Visual Feature Saliency Detection for Sea-Surface Targets through Improved Sea-Sky-Line Detection - Chang Lin; Wu Chen; Haifeng Zhou (Journal of Marine Science and Engineering, 2020)
To visually detect sea-surface targets, the objects of interest must be effectively and rapidly isolated from the background of sea-surface images. In contrast to traditional image detection methods, which employ a single visual feature, this paper proposes a significance detection algorithm based on the fusion of multi-visual features after detecting the sea-sky-lines. The gradient edges of the sea-surface images are enhanced using a Gaussian low-pass filter to eliminate the effect of the image gradients pertaining to the clouds, wave points, and illumination. The potential region and points of the sea-sky-line are identified. The sea-sky-line is fitted through polynomial iterations to obtain a sea-surface image containing the target object. The saliency subgraphs of the high and low frequency, gradient texture, luminance, and color antagonism features are fused to obtain an integrated saliency map of the sea-surface image. The saliency target area of the sea surface is segmented. The effectiveness of the proposed method was verified. The average detection rate and time for the sea-sky-line detection were 96.3% and 1.05 fps, respectively. The proposed method outperformed the existing saliency models on the marine obstacle detection dataset and Singapore maritime dataset, with mean absolute errors of 0.075 and 0.051, respectively.

A new macrocyclic diterpenoid from Anisomeles indica - Chen-Liang Chao; Hui-Chi Huang; Hsiou-Yu Ding; Jenn-Haung Lai; Hang-Ching Lin; Wen-Liang Chang (Natural Product Research, 2020)

Infusion of Human Mesenchymal Stem Cells Improves Regenerative Niche in Thioacetamide-Injured Mouse Liver - Ying-Hsien Kao; Yu-Chun Lin; Po-Huang Lee; Chia-Wei Lin; Po-Han Chen; Tzong-Shyuan Tai; Yo-Chen Chang; Ming-Huei Chou; Chih-Yang Chang; Cheuk-Kwan Sun (Tissue Engineering and Regenerative Medicine, 2020)

LMDS-1, a potential TrkB receptor agonist provides a safe and neurotrophic effect for early-phase Alzheimer’s disease - Chia-Hao Fan; Chia-Wei Lin; Hei-Jen Huang; Guey-Jen Lee-Chen; Ying-Chieh Sun; Wenwei Lin; Chiung-Mei Chen; Kuo-Hsuan Chang; Ming-Tsan Su; Hsiu Mei Hsieh-Li (Psychopharmacology, 2020)

Matriptase and prostasin proteolytic activities are differentially regulated in normal and wounded skin - Shun-Cheng Chang; Chien-Ping Chiang; Chih-Hsin Lai; Po-Wen A. Du; Yu-Sin Hung; Yu-Hsuan Chen; Hui-Yu Yang; Hao-Yu Fang; Shiao-Pieng Lee; Hung-Jen Tang; Jehng-Kang Wang; Michael D. Johnson; et al. (Human Cell, 2020)

An ensemble learning based hybrid model and framework for air pollution forecasting - Yue-Shan Chang; Satheesh Abimannan; Hsin-Ta Chiao; Chi-Yeh Lin; Yo-Ping Huang (Environmental Science and Pollution Research, 2020)

Complete Genome of Vibrio neocaledonicus CGJ02-2, An active Compounds Producing Bacterium Isolated from South China Sea - Lin Tan; Isabel Gómez-Betancur; Suxia Guo; Yu Ge; Jianping Zhao; Chang Chen; Nan Wang (Current Microbiology, 2020)

Roles of MicroRNA-122 in Cardiovascular Fibrosis and Related Diseases - Ying Liu; Jia-Wei Song; Jian-Yu Lin; Ran Miao; Jiu-Chang Zhong (Cardiovascular Toxicology, 2020)