The mutation of C-24 reductase, a key enzyme involved in brassinolide biosynthesis, confers a novel compact plant architecture phenotype to cucumber - Mengru Zhang; Mengfei Song; Marzieh Davoudi; Feng Cheng; Juan Yin; Gaohui Zha; Zhengan Yang; Jinfeng Chen; Qunfeng Lou (Theoretical and Applied Genetics, 2022)

The coordinated alterations in antioxidative enzymes, PeCu/ZnSOD and PeAPX2 expression facilitated in vitro Populus euphratica resistance to salinity stress - Kai Feng; Jinling Lu; Ying Chen; Yongya Luo; Yuchen Hu; Xuexia Li; Songzheng Zhong; Le Cheng (Plant Cell, Tissue and Organ Culture (PCTOC), 2022)

BcWRKY1 confers salt sensitivity via inhibiting Reactive oxygen species scavenging - Shuilin Yuan; Die Hu; Yuan Wang; Cen Shao; Tongkun Liu; Changwei Zhang; Feng Cheng; Xilin Hou; Ying Li (Plant Molecular Biology, 2022)

Causal Effect of Genetically Determined Blood Copper Concentrations on Multiple Diseases: A Mendelian Randomization and Phenome-Wide Association Study - Xiuming Feng; Wenjun Yang; Lulu Huang; Hong Cheng; Xiaoting Ge; Gaohui Zan; Yanli Tan; Lili Xiao; Chaoqun Liu; Xing Chen; Zengnan Mo; Longman Li; et al. (Phenomics, 2022)

Trophinin-associated protein expression correlates with shorter survival of patients with glioma: a study based on multiple data fusion analysis - Yong Sun; Zhen Dong Liu; Run Ze Liu; Xiao Yu Lian; Xing Bo Cheng; Yu Long Jia; Bin Feng Liu; Yan Zheng Gao; Xinjun Wang (Molecular Biology Reports, 2022)

The role of estrogen receptor β in fine particulate matter (PM2.5) organic extract-induced pulmonary inflammation in female and male mice - Huaqi Guo; Hengyi Yu; Yan Feng; Wei Cheng; Yan Li; Yan Wang (Environmental Science and Pollution Research, 2022)

Dissipation rates, residue distribution, degradation products, and degradation pathway of sulfoxaflor in broccoli - Guofeng Chen; Feng Liu; Xiaobo Zhang; Ruiying Zhang; Aihua Cheng; Dongmei Shi; Jiannan Dong; Hui Liao (Environmental Science and Pollution Research, 2022)

Analysis of the atmospheric direct dynamic source for the westerly extended WPSH and record-breaking Plum Rain in 2020 - Yuheng Zhao; Jianbo Cheng; Guolin Feng; Rong Zhi; Zhihai Zheng; Zengping Zhang (Climate Dynamics, 2022)

Optimum weighted arithmetic means of peak- and spectral-based intensity measures for probabilistic seismic demand modeling of modularized suspended buildings - Zhihang Ye; Abdollah Shafieezadeh; De-Cheng Feng; Gang Wu; Xiaowei Wang (Bulletin of Earthquake Engineering, 2022)

Selection and identification of a specific peptide binding to ovarian cancer cells from a phage-displayed peptide library - Qian Gao; Lirong Chen; Chenshuang Jia; Yue Yuan; Xinyao Li; Zheng Lu; Yang Feng; Ruixia Zhao; Xuewei Zhao; Yiwen Wang; Sinan Cheng; Caixia Zhang; et al. (Biotechnology Letters, 2022)

Assessing the joint effects of brain aging and gut microbiota on the risks of psychiatric disorders - Huijie Zhang; Li Liu; Shiqiang Cheng; Yumeng Jia; Yan Wen; Xuena Yang; Peilin Meng; Chun’e Li; Chuyu Pan; Yujing Chen; Zhen Zhang; Jingxi Zhang; et al. (Brain Imaging and Behavior, 2022)

Cohnella mopanensis sp. nov., a new Gram-negative bacterium isolated from soil in Xinping Mountain National Forest Park - Jing Tang; Jiang-Yuan Zhao; Le-Le Li; Zhang-Gui Ding; Shi-Qiang Ye; Cheng Ling; Meng-Yu Zhang; Song-Guo Liang; Jian-Yu Li; Pei-Wen Yang; Jiao Xiong; Lu-Yao Feng; et al. (Archives of Microbiology, 2022)

Slope aspect determines the abundance and composition of nitrogen‐cycling microbial communities in an alpine ecosystem - Jianbin Pan; Yongjun Liu; Yue Yang; Zhongxia Cheng; Xiaomei Lan; Weigang Hu; Guoxi Shi; Qi Zhang; Huyuan Feng (Environmental Microbiology, 2022)
Summary Slope aspect is an important topographic feature that can influence local environmental conditions. While strong effects of slope aspect on aboveground and belowground communities have been frequently elucidated, how slope aspect affects soil nitrogen (N) cycling microbes remains unclear. Here, we characterized the communities of soil N‐cycling microbes on south‐ and north‐facing slopes in an alpine ecosystem, by quantifying (qPCR) and high‐throughput sequencing six genes involved in N‐fixation ( nifH ), nitrification (archaeal and bacterial amoA ) and denitrification ( nirK , nirS and nosZ ). We found that the abundance, diversity and community composition of major N‐cycling microbes differed dramatically between the two slope aspects, and these variances could be well explained by the aspect‐driven differences in environmental conditions, especially soil temperature and moisture. The response patterns of different N‐cycling groups to slope aspect were much inconsistent, especially for those with similar functions (i.e. ammonia‐oxidizing archaea vs. bacteria, nirK ‐ vs. nirS ‐reducers), indicating strong niche differentiation between these counterparts. We also observed strong preferences and distinct co‐occurrence patterns of N‐cycling microbial taxa for the two slope aspects. These findings highlight the importance of slope aspect in determining the abundance, species distribution and community structure of N‐cycling microbes, and consequently influencing N‐cycling processes and ecosystem functioning.

Nitrogen Enrichment Reduces the Diversity of Bacteria and Alters Their Nutrient Strategies in Intertidal Zones - Yuan-Feng Xu; Xu-Meng Dong; Cheng Luo; Shuo-Nan Ma; Ji-Lin Xu; Yong-De Cui (Frontiers in Marine Science, 2022)
Intertidal ecosystems are affected by severe nitrogen (N) pollution as a result of anthropogenic activities, and it is unclear how this may affect intertidal microbial communities, which play critical roles in regulating biogeochemical cycles. To address this gap, we conducted a two-month mesocosm experiment using six targeted concentrations of total N. The findings indicated that N entering seawaters has direct negative effects on the bacterial diversity. Dose dependence was found for the effects of N on bacterial diversity in sediment: low N addition increased the bacterial diversity, but a reduction in bacterial diversity occurred when N exceeded a certain value (≥ 3 mg L−1). Additionally, N enrichment caused clear shifts in bacterial community composition with increases in the relative abundance of Balneola (organic-degrading), Phalacroma mitra (carbohydrate-fermenting), and Bacteroides (phosphorus (P)-solubilizing), and decreases in Leptolyngbya_PPC_6406 (N2-fixing). The increased abundance in P-solubilizing and organic-degrading bacteria and decrease in N-fixing bacteria, combined with the upregulated activity of alkaline phosphatase and downregulation of urease activity, implied that the bacterial assemblage tended to be more effective in P and carbon acquisition but reduced N acquisition. Further path analysis suggested that N had direct effects on bacteria and contributed 50%–100% to the variations in bacterial diversity, whereas environmental changes such as dissolved oxygen and pH played minor roles. Overall, bacteria occurring in sediment were likely more stress-resistant to high N exposure than those occurring in seawater, possibly due to the high buffering capacity of sediment and growth tolerances of bacteria in the sediment. These findings point to the vulnerability of microbes in water systems to increasing global N loading, and that N reduction is needed to combat the loss of microbial diversity.

Analysis of the July 2021 extreme precipitation in Henan using the novel moisture budget equation - Jianbo Cheng; Yuheng Zhao; Rong Zhi; Guolin Feng (Theoretical and Applied Climatology, 2022)

Hb New York, preliminary results concerning the hematologic characteristics and the effects on thalassemia - Zhuru Cheng; Xiaonian Zhu; Dan Zeng; Qiao Feng; Baodong Tian; Haiqing Zheng; Shengkui Tan; Chunjiang Zhu (Molecular Biology Reports, 2022)

Natural Vegetation Encroachment Improves Nutritional Conditions of Bauxite Residue Disposal Area - Nan Huang; Hao Wu; Feng Zhu; Qingyu Cheng; Shengguo Xue (Bulletin of Environmental Contamination and Toxicology, 2022)

Novel Plant Growth-Promoting Bacteria Isolated from Bauxite Residue: The Application for Revegetation - Li Chen; Qingyu Cheng; Xianchao Zhang; Mingxing Zhu; William Hartley; Feng Zhu (Bulletin of Environmental Contamination and Toxicology, 2022)

Effects of micronized bamboo powder on growth performance, serum biochemical indexes, cecal chyme microflora and metabolism of broilers aged 1–22 days - Fawen Dai; Tao Lin; Lumin Cheng; Jian Wang; Jianjun Zuo; Dingyuan Feng (Tropical Animal Health and Production, 2022)
Adding insoluble fiber to diet of broilers has been reported to improve intestinal health and promote growth performance. Bamboo powder is a cheap raw material with rich insoluble fiber. This study aims to explore the effects of feeding micronized bamboo powder (MBP) on growth performance, serum biochemical indexes, intestinal microflora, and metabolism of broilers. A total of 1440 1-day-old slow-growing Ephedra chickens were randomly divided into three groups considering gender and body weight: (1) Group D: feeding with basal diet without antibiotics; (2) Group E: feeding with basal diet supplemented with 5% rice bran (RB); (3) Group F: feeding with basal diet supplemented with 1% MBP. Each group involved 8 replicates feeding for 22 days, with 60 chickens per replicate. Various indexes were detected. For the growth performance, the weight gain and feed consumption ratio (G: F) of Group F supplemented with MBP is 0.57 ± 0.04, which is significantly higher than that of E group supplemented with RB (0.52 ± 0.01, P < 0.05). For the serum biochemical indexes, the glutathione peroxidase activity in Group F is significantly higher than that of Group D, while the malondialdehyde content is significantly lower than that of Group D and Group E ( P < 0.05 for all). The fresh cecal chyme is taken for determination. In Group F, the α diversity index Faith_pd is significantly lower in Group F than that of Group D. The microorganism species in cecal chyme of Group F and Group E are also different. The metabolic pathways of Group F, mainly in fatty acid metabolism, amino acid metabolism and intestinal immune IgA production, were different from those of Group D and Group E. Adding 1% MBP to broiler diet can enhance the anti-oxidant capacity, improve chyme microflora, regulate the metabolism pathways responsible for intestinal fatty acids, amino acids, and immunity.

Passive Surface-Wave Waveform Inversion for Source-Velocity Joint Imaging - Changjiang Zhou; Jianghai Xia; Feng Cheng; Jingyin Pang; Xinhua Chen; Huaixue Xing; Xiaojun Chang (Surveys in Geophysics, 2022)

Genetic dissection of heterotic loci associated with plant weight by Graded pool-seq in heading Chinese cabbage (Brassica rapa) - Lixin Yue; Rifei Sun; Guoliang Li; Feng Cheng; Limin Gao; Qinghua Wang; Shifan Zhang; Hui Zhang; Shujiang Zhang; Fei Li (Planta, 2022)

Molecular Mechanism of Selenium Affecting the Synthesis of Flavonoids in G. biloba Leaves - Kun Deng; Li Li; Linling Li; Feng Xu; Honghui Yuan; Sanxing Zha; Xian Xiao; Jie Yu; Shuiyuan Cheng; Hua Cheng (Plant Molecular Biology Reporter, 2022)

Sevoflurane inhibits the malignant phenotypes of glioma through regulating miR-146b-5p/NFIB axis - Haili Wang; Guofang Cheng; Lili Quan; Haibo Qu; Ailing Yang; Jiangge Ye; Yuanbo Feng; Xiaofang Li; Xiaoli Shi; Hua Pan (Metabolic Brain Disease, 2022)

Prediction of the sea buckthorn AQP gene structure and its spatiotemporal expression pattern under drought stress - Dan Zhang; Nanxiang Yang; Jiawei Dong; Cheng Wang; Qiangfeng Li; Rong Wang; Zhipeng Feng; Dejuan Xie; Guisheng Ye; Yuhua Ma (Journal of Plant Biochemistry and Biotechnology, 2022)

Association between atmospheric particulate matter and emergency room visits for cerebrovascular disease in Beijing, China - Bowen Cheng; Jianding Zhou; Yuxia Ma; Yifan Zhang; Hang Wang; Yan Chen; Jiahui Shen; Fengliu Feng (Journal of Environmental Health Science and Engineering, 2022)

Potential integration of wastewater treatment and natural pigment production by Phaeodactylum tricornutum: microalgal growth, nutrient removal, and fucoxanthin accumulation - Jinshun Jiang; Jianke Huang; Han Zhang; Zhen Zhang; Yi Du; Zheng Cheng; Bo Feng; Ting Yao; Aihua Zhang; Zhe Zhao (Journal of Applied Phycology, 2022)

Association between meteorological factors and hospital admissions for uveitis in Hefei, China: a time-series study - Fan Cao; Yi-Sheng He; Kun Xiang; Cheng-Huan Wan; Wei Liu; Yan-Chao Gui; Hai-Feng Pan; Zheng-Xuan Jiang; Li-Ming Tao (Environmental Science and Pollution Research, 2022)

Urinary polycyclic aromatic hydrocarbon metabolites and depression: a cross-sectional study of the National Health and Nutrition Examination Survey 2005–2016 - Xiaobing Feng; Ruyi Liang; Da Shi; Dongming Wang; Yanjun Guo; Weihong Qiu; Man Cheng; Tao Xu; Chaoqian Dong; Min Zhou; Weihong Chen (Environmental Science and Pollution Research, 2022)

The CO2 absorption and desorption analysis of tri-solvent MEA + EAE + AMP compared with MEA + BEA + AMP along with “coordination effects” evaluation - Huancong Shi; Xiaofang Cheng; Jiacheng Peng; Hongliang Feng; Paitoon Tontiwachwuthikul; Jiawei Hu (Environmental Science and Pollution Research, 2022)

Flow-slide characteristics and failure mechanism of shallow landslides in granite residual soil under heavy rainfall - Hui-lin Bai; Wen-kai Feng; Shuang-quan Li; Long-zhen Ye; Zhong-teng Wu; Rui Hu; Hong-chuan Dai; Yun-peng Hu; Xiao-yu Yi; Peng-cheng Deng (Journal of Mountain Science, 2022)

Comparison of different inversion methods of D-T2 two-dimensional nuclear magnetic resonance logging and applicability analysis - Cheng-Lin Li; Mao-Jin Tan; Ke-Wen Wang; Feng Zhou; Ying-Ming Liu; Hai-Tao Zhang; Li-Zhi Xiao (Applied Geophysics, 2022)

Quinoline, with the active site of 8‐hydroxyl, efficiently inhibits Micropterus salmoides rhabdovirus (MSRV) infection in vitro and in vivo - Bo‐Yang Li; Fei Yang; Zhong‐Yu Zhang; Yu‐Feng Shen; Tao Wang; Liang Zhao; Jia‐Cheng Qin; Fei Ling; Gao‐Xue Wang (Journal of Fish Diseases, 2022)
Micropterus salmoides rhabdovirus (MSRV) is an significant pathogen that causes high mortality and related economic losses in bass aquaculture. There is no effective or approved therapy to date. In this study, we evaluated the anti‐MSRV effects of 22 quinoline derivatives in grass carp ovary (GCO) cells. Among these compounds, 8‐hydroxyquinoline exhibited valid inhibition in decreasing MSRV nucleoprotein gene expression levels of 99.3% with a half‐maximal inhibitory concentrations (IC 50 ) value of 4.66 μM at 48 h. Moreover, 8‐hydroxyquinoline significantly enhanced a protective effect in GCO cells by reducing the cytopathic effect (CPE). By comparing the anti‐MSRV activity of 22 quinoline derivatives, we found that 8‐hydroxyquinoline possessed the efficient active site of 8‐hydroxyl and inhibited MSRV infection in vitro. For in vivo studies, 8‐hydroxyquinoline via intraperitoneal injection exhibited an antiviral effect in MSRV‐infected largemouth bass by substantially enhancing the survival rate by 15.0%. Importantly, the viral loads in the infected largemouth bass notably reduced in the spleen on the third days post‐infection. Overall, 8‐hydroxyquinoline was considered to be an efficient agent against MSRV in aquaculture.

NURBS-Based Parametric Design for Ship Hull Form - Hui Zhou; Baiwei Feng; Zuyuan Liu; Haichao Chang; Xide Cheng (Journal of Marine Science and Engineering, 2022)
Recently, the NURBS technique has been widely used in the 3D design software for ships. However, in most research, the NURBS technique is only applied to the mathematical representation of hull curves and surfaces, and the parametric deformation of hull surfaces based on geometric feature parameters is less understood. The aims of this paper are to establish the parametric design process of hull surfaces through the classification of geometric feature parameters and the design of feature curves, apply the NURBS technique to the parametric geometric modeling of hull curves and surfaces, and finally achieve the parametric deformation of hull surfaces driven by geometric feature parameters and develop the parametric deformation software. Taking the Series 60 ship as an example, we first analyze the hull geometric features and parameters, then design the longitudinal feature curves and cross-section curves based on the NURBS technique and establish the correlation between them, and finally generate the smooth hull surface by the skinning technique to achieve the parametric geometric deformation of the Series 60 ship. The research in this paper shows that the smoothness of the surfaces generated by the NURBS-based parametric design method is good. Additionally, the extracted feature parameters have a clear geometric meaning and can automatically generate hull forms to meet the design requirements quickly and effectively, which has some practical engineering value.

A new highly oxygenated germacranolide from Carpesium nepalense var. lanatum (C.B.Clarke) Kitam - Yi-Fan Yu; Yue-Qian Li; Ru-Yue Wang; Xu Liu; Wen-Bo Cui; Xiao-Han Chen; Cheng-Mu Zhao; Feng-Ming Qi; Zhan-Xin Zhang; Dong-Qing Fei (Natural Product Research, 2022)

Multiple indeterminate domain (IDD)–DELLA1 complexes participate in gibberellin feedback regulation in peach - Yajun Jiang; Jiajia Chen; Xianbo Zheng; Bin Tan; Xia Ye; Wei Wang; Langlang Zhang; Jidong Li; Zhiqian Li; Jun Cheng; Jiancan Feng (Plant Molecular Biology, 2022)

Histamine H1 Receptor in Basal Forebrain Cholinergic Circuit: A Novel Target for the Negative Symptoms of Schizophrenia? - Shuangshuang Wu; Chenshu Gao; Feng Han; Heming Cheng (Neuroscience Bulletin, 2022)

Dynamics of seasonal and interannual variability of the ocean bottom pressure in the Southern Ocean - Xiaoqin Xiong; Xuhua Cheng; Niansen Ou; Tao Feng; Jianhuang Qin; Xiao Chen; Rui Xin Huang (Acta Oceanologica Sinica, 2022)

Phenolic glycosides from Sanguisorba officinalis and their anti-inflammatory effects - Jin-feng Chen; Lu Tan; Feng Ju; Qi-xuan Kuang; Tian-long Yang; Fang Deng; Yu-cheng Gu; Li-shi Jiang; Yun Deng; Da-le Guo (Natural Product Research, 2022)

Chromenopyridin A, a new N -methoxy-1-pyridone alkaloid from the endophytic fungus Penicillium nothofagi P-6 isolated from the critically endangered conifer Abies beshanzuensis - Yuan-Xing Zhu; Cheng Peng; Wenxin Ding; Jin-Feng Hu; Jiyang Li (Natural Product Research, 2022)

Comparison of separated and combined photodegradation and biofiltration technology for the treatment of volatile organic compounds: A critical review - Meng-Fei Han; Xu-Rui Hu; Yong-Chao Wang; Zhen Tong; Can Wang; Zhuo-Wei Cheng; Ke Feng; Miao-Miao Qu; Jian-Meng Chen; Ji-Guang Deng; Hsing-Cheng Hsi (Critical Reviews in Environmental Science and Technology, 2022)

Response of urban tree DBH to fast urbanization: Case of coastal Zhanjiang in south China - Xia-Lan Cheng; Mir Muhammad Nizamani; Chi-Yung Jim; Salman Qureshi; Shuang Liu; Zhi-Xin Zhu; Si-Si Wu; Kelly Balfour; Hua-Feng Wang (Urban Ecosystems, 2022)

CitWRKY28 and CitNAC029 promote the synthesis of cuticular wax by activating CitKCS gene expression in citrus fruit - Hongbin Yang; Zhifeng Zhu; Mingfei Zhang; Xin Li; Rangwei Xu; Feng Zhu; Juan Xu; Xiuxin Deng; Yunjiang Cheng (Plant Cell Reports, 2022)

Effects of Chemotherapy on Neuroinflammation, Neuronal Damage, Neurogenesis, and Behavioral Performance in Bone Marrow Transplantation Recipient Mice - Zhong-Yuan Yu; Man-Yu Xu; Zhi-Hao Liu; Gui-Hua Zeng; Huan Fan; Cheng-Rong Tan; Yun-Feng Tu; Xian-Le Bu; Yan-Jiang Wang (Neurotoxicity Research, 2022)

Sex-specific effects of fluoride and lead exposures on histology, antioxidant physiology, and immune system in the liver of zebrafish (Danio rerio) - Guodong Wang; Tianyu Wang; Xiulin Zhang; Jianjie Chen; Cuiping Feng; Shaojun Yun; Yanfen Cheng; Feier Cheng; Jinling Cao (Ecotoxicology, 2022)

Imatinib-induced hepatotoxicity via oxidative stress and activation of NLRP3 inflammasome: an in vitro and in vivo study - Feng-Ru Huang; Wen-Tong Fang; Zi-Ping Cheng; Ye Shen; Dun-Jian Wang; Yong-Qing Wang; Lu-Ning Sun (Archives of Toxicology, 2022)

Influence of the NAO on Wintertime Surface Air Temperature over East Asia: Multidecadal Variability and Decadal Prediction - Jianping Li; Tiejun Xie; Xinxin Tang; Hao Wang; Cheng Sun; Juan Feng; Fei Zheng; Ruiqiang Ding (Advances in Atmospheric Sciences, 2022)
In this paper, we investigate the influence of the winter NAO on the multidecadal variability of winter East Asian surface air temperature (EASAT) and EASAT decadal prediction. The observational analysis shows that the winter EASAT and East Asian minimum SAT (EAmSAT) display strong in-phase fluctuations and a significant 60–80-year multidecadal variability, apart from a long-term warming trend. The winter EASAT experienced a decreasing trend in the last two decades, which is consistent with the occurrence of extremely cold events in East Asia winters in recent years. The winter NAO leads the detrended winter EASAT by 12–18 years with the greatest significant positive correlation at the lead time of 15 years. Further analysis shows that ENSO may affect winter EASAT interannual variability, but does not affect the robust lead relationship between the winter NAO and EASAT. We present the coupled oceanic-atmospheric bridge (COAB) mechanism of the NAO influences on winter EASAT multidecadal variability through its accumulated delayed effect of ∼15 years on the Atlantic Multidecadal Oscillation (AMO) and Africa–Asia multidecadal teleconnection (AAMT) pattern. An NAO-based linear model for predicting winter decadal EASAT is constructed on the principle of the COAB mechanism, with good hindcast performance. The winter EASAT for 2020–34 is predicted to keep on fluctuating downward until ∼2025, implying a high probability of occurrence of extremely cold events in coming winters in East Asia, followed by a sudden turn towards sharp warming. The predicted 2020/21 winter EASAT is almost the same as the 2019/20 winter.

Submesoscale motions and their seasonality in the northern Bay of Bengal - Lanman Li; Xuhua Cheng; Zhiyou Jing; Haijin Cao; Tao Feng (Acta Oceanologica Sinica, 2022)

Expansion of bilin‐based red light sensors in the subaerial desert cyanobacterium Nostoc flagelliforme - Hai‐Feng Xu; Guo‐Zheng Dai; Yu‐Jie Wang; Chao Cheng; Jin‐Long Shang; Ren‐Han Li; Ke Liu; Deqiang Duanmu; Bao‐Sheng Qiu (Environmental Microbiology, 2022)
Summary Light is the crucial environmental signal for desiccation‐tolerant cyanobacteria to activate photosynthesis and prepare for desiccation at dawn. However, the photobiological characteristics of desert cyanobacteria adaptation to one of the harshest habitats on Earth remain unresolved. In this study, we surveyed the genome of a subaerial desert cyanobacterium Nostoc flagelliforme and identified two phytochromes and seven cyanobacteriochromes (CBCRs) with one or more bilin‐binding GAF (cGMP phosphodiesterase/adenylyl cyclase/FhlA) domains. Biochemical and spectroscopic analyses of 69 purified GAF‐containing proteins from recombinant phycocyanobilin (PCB), biliverdin or phycoerythrobilin‐producing Escherichia coli indicated that nine of these proteins bind chromophores. Further investigation revealed that 11 GAFs form covalent adducts responsive to near‐UV and visible light: eight GAFs contained PCB chromophores, three GAFs contained biliverdin chromophores and one contained the PCB isomer, phycoviolobilin. Interestingly, COO91_03972 is the first‐ever reported GAF‐only CBCR capable of sensing five wavelengths of light. Bioinformatics and biochemical analyses revealed that residue P132 of COO91_03972 is essential for chromophore binding to dual‐cysteine CBCRs. Furthermore, the complement of N . flagelliforme CBCRs is enriched in red light sensors. We hypothesize that these sensors are critical for the acclimatization of N . flagelliforme to weak light environments at dawn.

Unexpected role of electron‐transfer hub in direct degradation of pollutants by exoelectrogenic bacteria - Ting‐Ting Zhu; Zhou‐Hua Cheng; Sheng‐Song Yu; Wen‐Wei Li; Dong‐Feng Liu; Han‐Qing Yu (Environmental Microbiology, 2022)
Summary Exoelectrogenic bacteria (EEB) are capable of anaerobic respiration with diverse extracellular electron acceptors including insoluble minerals, electrodes and flavins, but the detailed electron transfer pathways and reaction mechanisms remain elusive. Here, we discover that CymA, which is usually considered to solely serve as an inner‐membrane electron transfer hub in Shewanella oneidensis MR‐1 (a model EEB), might also function as a reductase for direct reducing diverse nitroaromatic compounds (e.g. 2,4‐dichloronitrobenzene) and azo dyes. Such a process can be accelerated by dosing anthraquinone‐2,6‐disulfonate. The CymA‐based reduction pathways in S . oneidensis MR‐1 for different contaminants could be functionally reconstructed and strengthened in Escherichia coli . The direct reduction of lowly polar contaminants by quinol oxidases like CymA homologues might be universal in diverse microbes. This work offers new insights into the pollutant reduction mechanisms of EEB and unveils a new function of CymA to act as a terminal reductase.

Petrogenesis and tectonic setting of the early-middle triassic subduction-related granite in the eastern segment of East Kunlun: evidences from petrology, geochemistry, and zircon U-Pb-Hf isotopes - Zuo-Chen Li; Xian-Zhi Pei; Paul D. Bons; Rui-Bao Li; Lei Pei; Guo-Chao Chen; You-Xin Chen; Cheng-Jun Liu; Meng Wang; Shao-Wei Zhao; Xiao-Bing Li; Feng Gao (International Geology Review, 2022)

Characterization of Photorhabdus Virulence Cassette as a causative agent in the emerging pathogen Photorhabdus asymbiotica - Xia Wang; Jiaxuan Cheng; Jiawei Shen; Liguo Liu; Ningning Li; Ning Gao; Feng Jiang; Qi Jin (Science China Life Sciences, 2022)

Comparative Transcriptomic Analysis Reveals the Regulatory Mechanism of Terpene Trilactones Improvement by Exogenous Methyl Jasmonate in Ginkgo biloba - Junping Tan; Muxian Han; Dun Mao; Shuiyuan Cheng; Jiabao Ye; Xiaomeng Liu; Xian Zhang; Jiarui Zheng; Feng Xu; Zexiong Chen; Weiwei Zhang; Yongling Liao (Plant Molecular Biology Reporter, 2022)

Circular RNA circ_0008934 promotes hepatocellular carcinoma growth and metastasis through modulating miR-1305/TMTC3 axis - Jia-Xi Li; Jin-Jiang Wang; Zhou-Feng Deng; Hao Zheng; Chun-Mei Yang; Ying Yuan; Cheng Yang; Fang-Fang Gu; Wei-Qi Wu; Guang-Lei Qiao; Li-Jun Ma (Human Cell, 2022)

Superior degradation of phenolic contaminants in different water matrices via non-radical Fenton-like mechanism mediated by surface-disordered WO3 - Ai-Yong Zhang; Shuo Xu; Jing-Wei Feng; Pin-Cheng Zhao; Heng Liang (Environmental Science and Pollution Research, 2022)

Adaptation capability of rainfall hotspots in water resilient cities using QGIS: a case study of Taichung City in Taiwan - Ming-jen Cheng; Wei-liang Sia; Feng-chi Liao; Li-shin Chang (Environmental Monitoring and Assessment, 2022)

A bi-scale assessing framework for aesthetic ecosystem services of villages in a world heritage site - Yin-ping Ding; Zhi-lin Liu; Yuan-mei Jiao; Qiu-e Xu; Kan-feng Zhang; Cheng-jing Liu; Fan Chen (Journal of Mountain Science, 2022)

Design, synthesis and agricultural evaluation of derivatives of N-Acyl-N-(m-fluoro-benzyl)-6-amino-coumarin - Yan Jin; Yin-hao Ding; Jing-jing Dong; Yan Wei; Shuang-hong Hao; Bai-cheng Feng (Natural Product Research, 2022)

Transcriptomic analysis of formic acid stress response in Saccharomyces cerevisiae - Lingjie Zeng; Jinxiang Huang; Pixue Feng; Xuemei Zhao; Zaiyong Si; Xiufeng Long; Qianwei Cheng; Yi Yi (World Journal of Microbiology and Biotechnology, 2022)

Cancer metabolism and tumor microenvironment: fostering each other? - Yiyuan Yuan; Huimin Li; Wang Pu; Leilei Chen; Dong Guo; Hongfei Jiang; Bo He; Siyuan Qin; Kui Wang; Na Li; Jingwei Feng; Jing Wen; et al. (Science China Life Sciences, 2022)

Structure modification, antialgal, antiplasmodial, and toxic evaluations of a series of new marine-derived 14-membered resorcylic acid lactone derivatives - Wei-Feng Xu; Na-Na Wu; Yan-Wei Wu; Yue-Xuan Qi; Mei-Yan Wei; Laura M. Pineda; Michelle G. Ng; Carmenza Spadafora; Ji-Yong Zheng; Ling Lu; Chang-Yun Wang; Yu-Cheng Gu; et al. (Marine Life Science & Technology, 2022)
Marine natural products play critical roles in the chemical defense of many marine organisms and are essential, reputable sources of successful drug leads. Sixty-seven 14-membered resorcylic acid lactone derivatives 3 – 27 and 30 – 71 of the natural product zeaenol ( 1 ) isolated from the marine-derived fungus Cochliobolus lunatus were semisynthesized by chlorination, acylation, esterification, and acetalization in one to three steps. The structures of these new derivatives were established by HRESIMS and NMR techniques. All the compounds ( 1 – 71 ) were evaluated for their antialgal and antiplasmodial activities. Among them, 14 compounds displayed antifouling activities against adhesion of the fouling diatoms. In particular, 9 and 34 exhibited strong and selective inhibitory effects against the diatoms Navicula laevissima and Navicula exigua (EC 50 = 6.67 and 8.55 μmol/L), respectively, which were similar in efficacy to those of the positive control SeaNine 211 (EC 50 = 2.90 and 9.74 μmol/L). More importantly, 38 , 39 , and 69 – 71 showed potent antiplasmodial activities against Plasmodium falciparum with IC 50 values ranging from 3.54 to 9.72 μmol/L. Very interestingly, the five antiplasmodial derivatives displayed non-toxicity in the cytotoxicity assays and the zebrafish embryos model, thus, representing potential promising antiplasmodial drug agents. The preliminary structure–activity relationships indicated that biphenyl substituent at C-2, acetonide at positions C-5′ and C-6′, and tri- or tetra-substituted of acyl groups increased the antiplasmodial activity. Therefore, combining evaluation of chemical ecology with pharmacological models will be implemented as a systematic strategy, not only for environmentally friendly antifoulants but also for structurally novel drugs.

A system dynamic model for simulating the potential of prefabrication on construction waste reduction - Ruijia Yuan; Feng Guo; Yingmiao Qian; Baoquan Cheng; Jianchang Li; Xiaoying Tang; Xiaojing Peng (Environmental Science and Pollution Research, 2022)

The zonal gradient structures of wintertime SST anomalies in the equatorial Pacific and their connection to the Walker circulation - Yuheng Zhao; Zhihai Zheng; Rong Zhi; Guolin Feng; Jianbo Cheng (Climate Dynamics, 2022)

Functional alterations of the suicidal brain: a coordinate-based meta-analysis of functional imaging studies - Cheng-feng Chen; Wang-ni Chen; Bin Zhang (Brain Imaging and Behavior, 2022)

Planning hierarchical hospital service areas for maternal care using a network optimization approach: A case study in Hubei, China - Zhuolin Tao; Yang Cheng; Lingyao Bai; Ling Feng; Shaoshuai Wang (Journal of Geographical Sciences, 2022)

Genome-wide identification and expression analysis of GL2-interacting-repressor (GIR) genes during cotton fiber and fuzz development - Xiaoxu Feng; Hailiang Cheng; Dongyun Zuo; Youping Zhang; Qiaolian Wang; Limin Lv; Shuyan Li; John Z. Yu; Guoli Song (Planta, 2022)

YAP regulates porcine skin-derived stem cells self-renewal partly by repressing Wnt/β-catenin signaling pathway - Hong-Chen Yan; Yu Sun; Ming-Yu Zhang; Shu-Er Zhang; Jia-Dong Sun; Paul W. Dyce; Francesca Gioia Klinger; Massimo De Felici; Wei Shen; Shun-Feng Cheng (Histochemistry and Cell Biology, 2022)

Associations between lung-deposited dose of particulate matter and culture-positive pulmonary tuberculosis pleurisy - Kuan-Jen Bai; Nguyen Thanh Tung; Ta-Chih Hsiao; Tsai-Ling Chen; Kian Fan Chung; Shu-Chuan Ho; Cheng-Yu Tsai; Jen-Kun Chen; Chun-Nin Lee; Kang-Yun Lee; Chih-Cheng Chang; Tzu-Tao Chen; et al. (Environmental Science and Pollution Research, 2022)

Association of hearing loss with total and cause-specific mortality in US adults - Xiaobing Feng; Wenzhen Li; Man Cheng; Weihong Qiu; Ruyi Liang; Minjing Li; Weihong Chen; Dongming Wang (Environmental Science and Pollution Research, 2022)

Probabilistic seismic demand and fragility analysis of a novel mid-rise large-span cassette structure - Zhi-Peng Chen; De-Cheng Feng; Xu-Yang Cao; Ke-Jian Ma; Songye Zhu; Gang Wu (Bulletin of Earthquake Engineering, 2022)

Adenine base-editing-mediated exon skipping induces gene knockout in cultured pig cells - Xiang-xing Zhu; Jia-sheng Pan; Tao Lin; Ye-cheng Yang; Qiu-yan Huang; Shuai-peng Yang; Zi-xiao Qu; Zi-sheng Lin; Jian-cong Wen; Ai-fen Yan; Juan Feng; Lian Liu; et al. (Biotechnology Letters, 2022)

Using computational fluid dynamic simulation with Flow-3D to reveal the origin of the mushroom stone in the Xiqiao Mountain of Guangdong, China - Jian-cheng Li; Wei Wang; Yan-ming Zheng; Xiao-hao Wen; Jing Feng; Li Sheng; Chen Wang; Ming-kun Qiu (Journal of Mountain Science, 2022)

Nakamurella leprariae sp. nov., isolated from a lichen sample - De-Feng An; Shao-Juan Yang; Long-Qian Jiang; Xin-Yu Wang; Xiao-Yu Huang; Lei Lang; Xue-Mei Chen; Ming-Qun Fan; Gui-Ding Li; Ming-Guo Jiang; Li-Song Wang; Cheng-Lin Jiang; et al. (Archives of Microbiology, 2022)

Longitudinal virological changes and underlying pathogenesis in hospitalized COVID-19 patients in Guangzhou, China - Zhengtu Li; Yinhu Li; Ruilin Sun; Shaoqiang Li; Lingdan Chen; Yangqing Zhan; Mingzhou Xie; Jiasheng Yang; Yanqun Wang; Airu Zhu; Guoping Gu; Le Yu; et al. (Science China Life Sciences, 2021)

Investigation on the macro- and microdeformation characteristics of silty clay under different shield construction stress paths - Huayang Lei; Zeyu Cheng; Shuangxi Feng; Jinfeng Lou; Haichen Zhong (Bulletin of Engineering Geology and the Environment, 2021)

Biological synthesis of nicotinamide mononucleotide - Qi Shen; Shi-Jia Zhang; Yu-Zhen Xue; Feng Peng; Dong-Yuan Cheng; Ya-Ping Xue; Yu-Guo Zheng (Biotechnology Letters, 2021)

Study on the Pyrolysis Characteristics, Kinetics and Mineral Transformation of Paper Sludge - Yanshan Yin; Huixia Yin; Zihan Yuan; Zihua Wu; Wei Zhang; Hong Tian; Leihua Feng; Shan Cheng; Mengxia Qing; Quanbin Song (BioEnergy Research, 2021)

Application of Feature Point Matching Technology to Identify Images of Free-Swimming Tuna Schools in a Purse Seine Fishery - Qinglian Hou; Cheng Zhou; Rong Wan; Junbo Zhang; Feng Xue (Journal of Marine Science and Engineering, 2021)
Tuna fish school detection provides information on the fishing decisions of purse seine fleets. Here, we present a recognition system that included fish shoal image acquisition, point extraction, point matching, and data storage. Points are a crucial characteristic for images of free-swimming tuna schools, and point algorithm analysis and point matching were studied for their applications in fish shoal recognition. The feature points were obtained by using one of the best point algorithms (scale invariant feature transform, speeded up robust features, oriented fast and rotated brief). The k-nearest neighbors (KNN) algorithm uses ‘feature similarity’ to predict the values of new points, which means that new data points will be assigned a value based on how closely they match the points that exist in the database. Finally, we tested the model, and the experimental results show that the proposed method can accurately and effectively recognize tuna free-swimming schools.

A Unique Diel Pattern in Carbonate Chemistry in the Seagrass Meadows of Dongsha Island: The Enhancement of Metabolic Carbonate Dissolution in a Semienclosed Lagoon - Wen-Chen Chou; Lan-Feng Fan; Chang-Chang Yang; Ying-Hsuan Chen; Chin-Chang Hung; Wei-Jen Huang; Yung-Yen Shih; Keryea Soong; Hsiao-Chun Tseng; Gwo-Ching Gong; Hung-Yu Chen; Cheng-Kuan Su (Frontiers in Marine Science, 2021)
In contrast to other seagrass meadows where seawater carbonate chemistry generally shows strong diel variations with higher pH but lower partial pressure of CO 2 ( p CO 2 ) during the daytime and lower pH but higher p CO 2 during nighttime due to the alternation in photosynthesis and respiration, the seagrass meadows of the inner lagoon (IL) on Dongsha Island had a unique diel pattern with extremely high pH and low p CO 2 across a diel cycle. We suggest that this distinct diel pattern in pH and p CO 2 could be associated with the enhancement of total alkalinity (TA) production coupled to carbonate sediment dissolution in a semienclosed lagoon. The confinement of the IL may hamper water exchange and seagrass detritus export to the adjacent open ocean, which may result in higher organic matter loading to the sediments, and longer residence time of the water in the IL, accompanied by microbial respiration (both aerobic and anaerobic) that may reduce carbonate saturation level to drive carbonate dissolution and thus TA elevation, thereby forming such a unique diel pattern in carbonate chemistry. This finding further highlights the importance of considering TA production through metabolic carbonate dissolution when evaluating the potential of coastal blue carbon ecosystems to buffer ocean acidification and to absorb atmospheric CO 2 , in particular in a semienclosed setting.

miR-124-3p targeted SIRT1 to regulate cell apoptosis, inflammatory response, and oxidative stress in acute myocardial infarction in rats via modulation of the FGF21/CREB/PGC1α pathway - Yun-Jie Wei; Jun-Feng Wang; Fei Cheng; Hai-Jun Xu; Jia-Juan Chen; Jian Xiong; Jing Wang (Journal of Physiology and Biochemistry, 2021)

PGC-1ɑ Mediated-EXOG, a Specific Repair Enzyme for Mitochondrial DNA, Plays an Essential Role in the Rotenone-Induced Neurotoxicity of PC12 Cells - Jingsong Xiao; Xunhu Dong; Kaige Peng; Feng Ye; Jin Cheng; Guorong Dan; Zhongmin Zou; Jia Cao; Yan Sai (Journal of Molecular Neuroscience, 2021)

Transformation of bisphenol AF by chlorination: kinetic study and product identification - Jingyi Chang; Wenrui Xiang; Ruijuan Qu; Cheng Sun; Zunyao Wang; Feng Zhu; Zongli Huo (Environmental Science and Pollution Research, 2021)

Aflatoxins from the endophytic fungus Aspergillus sp. Y-2 isolated from the critically endangered conifer Abies beshanzuensis - Yuan-Xing Zhu; Cheng Peng; Shui Yu; Jin-Feng Hu; Jiyang Li (Natural Product Research, 2021)

Circ_0020093 ameliorates IL-1β-induced apoptosis and extracellular matrix degradation of human chondrocytes by upregulating SPRY1 via targeting miR-23b - Mingli Feng; Lin Jing; Jingbo Cheng; Shuai An; Jiang Huang; Qi Yan (Molecular and Cellular Biochemistry, 2021)
Osteoarthritis (OA) is a chronic disease characterized by articular cartilage degeneration and uncontrolled chondrocyte apoptosis. At present, accumulating evidence introduces that circular RNA (circRNA) is involved in the development of OA. The aim of our study was to explore the role and the functional mechanism of circ_0020093 in OA cell model. Human chondrocytes were treated with interleukin-1 beta (IL-1β) to construct OA model. The expression of circ_0020093, miR-23b, and Sprouty 1 (SPRY1) mRNA was measured by quantitative real-time polymerase chain reaction (qRT-PCR). Cell apoptosis was assessed by flow cytometry assay. The expression of extracellular matrix (ECM)-associated markers and SPRY1 protein level was detected by qRT-PCR and Western blot. Bioinformatics analysis-predicted relationship between miR-23b and circ_0020093 or SPRY1 was further verified by dual-luciferase reporter assay and RNA pull-down assay. In this study, we found that the expression of circ_0020093 and SPRY1 was declined, while miR-23b expression was elevated in IL-1β-treated chondrocytes. IL-1β induced chondrocyte apoptosis and ECM degradation, while these negative effects were alleviated by circ_0020093 overexpression or miR-23b inhibition. MiR-23b was a target of circ_0020093, and SPRY1 was a downstream target of miR-23b. Rescue experiments showed that miR-23b enrichment reversed the role of circ_0020093 overexpression, and SPRY1 knockdown also reversed the effects of miR-23b inhibition. Importantly, circ_0020093 positively regulated SPRY1 expression by targeting miR-23b. In conclusion, circ_0020093 ameliorates IL-1β-induced apoptosis and ECM degradation of human chondrocytes by regulating the miR-23b/SPRY1 axis.

A study on the short-term effect of particulate matter pollution on hospital visits for asthma in children in Shanghai, China - Zhiang Yu; Yuxia Ma; Yifan Zhang; Bowen Cheng; Fengliu Feng; Bingji Ma; Haoran Jiao; Ji Zhou (Environmental Geochemistry and Health, 2021)

Low-Se Diet Can Affect Sperm Quality and Testicular Glutathione Peroxidase-4 activity in Rats - Qin Wang; Shuo Zhan; Yiqun Liu; Feng Han; Lili Shi; Chao Han; Weipeng Mu; Jizhong Cheng; Zhen-wu Huang (Biological Trace Element Research, 2021)

Formation process and internal architecture of wave dominated beach-bar along the lake shore: insights from a flume experiment - Cheng Lei; Xinmin Song; Xinjun Gao; Ruifeng Wang; Guanghua Zhai; Qingyan Xu; Wenjie Feng; Yanshu Yin (Arabian Journal of Geosciences, 2021)

Genomic molecular signatures determined characterization of Mycolicibacterium gossypii sp. nov., a fast-growing mycobacterial species isolated from cotton field soil - Rui-Rui Huang; Shen-Rong Yang; Cheng Zhen; Xian-Feng Ge; Xin-Kai Chen; Zhi-Qiang Wen; Ya-Nan Li; Wen-Zheng Liu (Antonie van Leeuwenhoek, 2021)

Evaluation of the antiviral activity of naringenin, a major constituent of Typha angustifolia , against white spot syndrome virus in crayfish Procambarus clarkii - Zhong‐Chen Sun; Cheng Chen; Fei‐Fan Xu; Bing‐Ke Li; Jing‐Lei Shen; Tao Wang; Hai‐Feng Jiang; Gao‐Xue Wang (Journal of Fish Diseases, 2021)
White spot syndrome virus (WSSV) is a serious pathogen threatening global crustacean aquaculture with no commercially available drugs. Herbal medicines widely used in antiviral research offer a rich reserve for drug discovery. Here, we investigated the inhibitory activity of 13 herbal medicines against WSSV in crayfish Procambarus clarkii and discovered that naringenin (NAR) has potent anti‐WSSV activity. In the preliminary screening, the extracts of Typha angustifolia displayed the highest inhibitory activity on WSSV replication (84.62%, 100 mg/kg). Further, NAR, the main active compound of T. angustifolia, showed a much higher inhibition rate (92.85%, 50 mg/kg). NAR repressed WSSV proliferation followed a dose‐dependent manner and significantly improved the survival of WSSV‐challenged crayfish. Moreover, pre‐ or post‐treatment of NAR displayed a comparable inhibition on the viral loads. NAR decreased the transcriptional levels of vital genes in viral life cycle, particularly for the immediately early‐stage gene ie1 . Further results showed that NAR could decrease the STAT gene expression to block ie1 transcription. Besides, NAR modulated immune‐related gene Hsp70 , antioxidant ( cMnSOD, mMnSOD, CAT, GST ), anti‐inflammatory ( COX‐1 , COX‐2 ) and pro‐apoptosis‐related factors (Bax and BI‐1) to inhibit WSSV replication. Overall, these results suggest that NAR may have the potential to be developed as preventive or therapeutic agent against WSSV.

Application of Basis Functions for Hull Form Surface Modification - Baiwei Feng; Chengsheng Zhan; Zuyuan Liu; Xide Cheng; Haichao Chang (Journal of Marine Science and Engineering, 2021)
Basis functions are key in constructing interpolation equations in hull surface modification based on radial basis functions (RBF) interpolation. However, few have studied the selection of basis functions in depth. By comparing several typical basis functions through a theoretical analysis and two-dimensional modification examples, the Wendland ψ3,1 (W) function is selected. The advantages of hull form surface modification based on W function interpolation are further validated through a case study. Finally, the modification method is used to optimize a trimaran model. An optimal hull form with fair lines is obtained, and its wave-making resistance coefficient and total resistance are reduced by 8.3% and 3.8%, respectively, compared to those of the original model. These findings not only further illustrate that the W function is relatively suitable for hull form surface modification, but also validate the feasibility and value of the RBF interpolation-based surface modification method in engineering practice.

Information Matrix-Based Adaptive Sampling in Hull Form Optimisation - Xuyu Ouyang; Haichao Chang; Baiwei Feng; Zuyuan Liu; Chengsheng Zhan; Xide Cheng (Journal of Marine Science and Engineering, 2021)
Hull form optimisation involves challenges such as large design spaces, numerous design variables, and high nonlinearity. Therefore, optimisation that only use global approximate models alone cannot yield desirable results. An information matrix-based method is proposed for dynamically embedded local approximate models (IM-DEAM) in this paper, which uses the Gaussian-function information matrix to extract one or more subspaces for additional sampling and a Latin hypercube design (LHD) for adaptive sampling. In addition, to prevent overfitting by global approximate models in some spaces because of the uneven distribution of the samples, local approximate models are embedded in the subspaces identified for additional sampling to enable accurate description of subspaces. The effectiveness and robustness of the method are validated and analysed by applying the proposed method to optimise mathematical functions and the hull form of the DTMB 5415. The results demonstrate that the proposed method is effective for improving the accuracies and can produce reliable optimisation results.

Effects of Fatigue on Inter-joint Coordination in Ballet Dancers During a Ballet Jumping Movement (petit échappé sauté) - Chai-Wei Lin; Jeng-Feng Yang; Yi-An Chen; Cheng-Feng Lin (Journal of Medical and Biological Engineering, 2021)

Correction to: Chemical Speciation and Interaction Mechanism of U in “Shewanella putrefaciens-Mineral-U” System - J. Gao; W. Yuan; J. Cheng; J. Zhang; S. Feng; F. Huang; F. Yi; H. Huang; H. Zhang (Water, Air, & Soil Pollution, 2021)

HDAC inhibitors improve CRISPR-mediated HDR editing efficiency in iPSCs - Jian-Ping Zhang; Zhi-Xue Yang; Feng Zhang; Ya-Wen Fu; Xin-Yue Dai; Wei Wen; Beldon Zhang; Hannah Choi; Wanqiu Chen; Meredith Brown; David Baylink; Lei Zhang; et al. (Science China Life Sciences, 2021)

Effect of straw application time on soil properties and microbial community in the Northeast China Plain - Liwei Wang; Cheng Wang; Fangyuan Feng; Zhengniu Wu; Hongkui Yan (Journal of Soils and Sediments, 2021)

Evolutionary Changes in Pathways and Networks of Genes Expressed in the Brains of Humans and Macaques - Yuequn Ma; Changying Cao; Mengwen Zhao; Xinhua Liu; Feng Cheng; Ju Wang (Journal of Molecular Neuroscience, 2021)

Pesticides Exposure and Dopaminergic Neurodegeneration - Jingsong Xiao; Xunhu Dong; Xi Zhang; Feng Ye; Jin Cheng; Guorong Dan; Yuanpeng Zhao; Zhongmin Zou; Jia Cao; Yan Sai (Exposure and Health, 2021)

Effects of extreme temperature on respiratory diseases in Lanzhou, a temperate climate city of China - Fengliu Feng; Yuxia Ma; Yifan Zhang; Jiahui Shen; Hang Wang; Bowen Cheng; Haoran Jiao (Environmental Science and Pollution Research, 2021)

Association between environmental factors and COVID-19 in Shanghai, China - Yuxia Ma; Bowen Cheng; Jiahui Shen; Hang Wang; Fengliu Feng; Yifan Zhang; Haoran Jiao (Environmental Science and Pollution Research, 2021)

Apatite as an alternative petrochronometer to trace the evolution of magmatic systems containing metamict zircon - Hao-Cheng Yu; Kun-Feng Qiu; Callum J. Hetherington; David Chew; Ya-Qi Huang; Deng-Yang He; Jian-Zhen Geng; Hai-Yang Xian (Contributions to Mineralogy and Petrology, 2021)

Novel Dicistroviruses in an Unexpected Wide Range of Invertebrates - Ruo-Lin Cheng; Xiao-Feng Li; Chuan-Xi Zhang (Food and Environmental Virology, 2021)

3D Step-by-step inversion strategy for audio magnetotellurics data based on unstructured mesh - San Cheng; Zhi-Yong Zhang; Feng Zhou; Man Li; Hui Chen; Fu-Sheng Shi; Lin-Pin Huang; Yong Li (Applied Geophysics, 2021)

Spatiotemporal characteristics and trend assessment of Ms ≥ 5.6 earthquakes in the Tianshan area of China based on co-occurrence analysis and commensurability - Jia Wan; Jun-Ping Yan; Zi-Qiang Liu; Xiao-Meng Wang; Yu-Feng Zhang; Cheng-Bo Wang (Applied Geophysics, 2021)

Chemical Speciation and Interaction Mechanism of U in “Shewanella putrefaciens-Mineral-U” System - Jingqi Gao; Fengyu Huang; Wenjuan Yuan; Juan Cheng; Hexiang Huang; Jie Zhang; Facheng Yi; Hailing Zhang; Su Feng (Water, Air, & Soil Pollution, 2021)

A New Direct Shear Apparatus for Rock Joints Specialized in Cyclic Loading - Zhen Cui; Qian Sheng; Mao-chu Zhang; Jun-feng Cao; Xian-cheng Mei; Qing-zi Luo (Rock Mechanics and Rock Engineering, 2021)

Talaromyces Marneffei Infection in an HIV-Negative Child with a CARD9 Mutation in China: A Case Report and Review of the Literature - Cheng-yan You; Fang Hu; Si-wei Lu; Dan-dan Pi; Feng Xu; Cheng-jun Liu; Yue-qiang Fu (Mycopathologia, 2021)

Characterization of AV422 from Haemaphysalis flava ticks in vitro - Lei Liu; Hao Tang; De-yong Duan; Jin-bao Liu; Jie Wang; Li-li Feng; Tian-yin Cheng (Experimental and Applied Acarology, 2021)

RSF1 requires CEBP/β and hSNF2H to promote IL-1β-mediated angiogenesis: the clinical and therapeutic relevance of RSF1 overexpression and amplification in myxofibrosarcomas - Chien-Feng Li; Ti-Chen Chan; Cheng-I. Wang; Fu-Min Fang; Po-Chun Lin; Shih-Chen Yu; Hsuan-Ying Huang (Angiogenesis, 2021)

Identification of a putative candidate gene encoding 7-dehydrocholesterol reductase involved in brassinosteroids biosynthesis for compact plant architecture in Cucumber (Cucumis sativus L.) - Mengru Zhang; Mengfei Song; Feng Cheng; Zhige Yang; Marzieh Davoudi; Jinfeng Chen; Qunfeng Lou (Theoretical and Applied Genetics, 2021)

Geoscience knowledge graph in the big data era - Chenghu Zhou; Hua Wang; Chengshan Wang; Zengqian Hou; Zhiming Zheng; Shuzhong Shen; Qiuming Cheng; Zhiqiang Feng; Xinbing Wang; Hairong Lv; Junxuan Fan; Xiumian Hu; et al. (Science China Earth Sciences, 2021)

Citrus NIP5;1 aquaporin regulates cell membrane water permeability and alters PIPs plasma membrane localization - Mingfei Zhang; Ruilian Liu; Hai Liu; Hongbin Yang; Xin Li; Ping Wang; Feng Zhu; Rangwei Xu; Shaowu Xue; Yunjiang Cheng (Plant Molecular Biology, 2021)

The influence of VDR polymorphisms on the type 2 diabetes susceptibility in Chinese: an interaction with hypertriglyceridemia - Dongdong Zhang; Cheng Cheng; Yan Wang; Yuan Xue; Yaping Liu; Yiming Liu; Mingming Feng; Ze Xu; Wenjie Li; Xing Li (Molecular Genetics and Genomics, 2021)

Investigation on creep behavior of warm frozen silty sand under thermo-mechanical coupling loads - Feng Zhang; Sheng Shi; De-cheng Feng; Lei-zhou Cai (Journal of Mountain Science, 2021)

Glaciibacter flavus sp. nov., isolated from a lichen sample - De-Feng An; Long-Qian Jiang; Kun Zhang; Gui-Ding Li; Xin-Yu Wang; Ming-Guo Jiang; Lei Lang; Li-Song Wang; Johannes F. Imhoff; Cheng-Lin Jiang; Yi Jiang (Archives of Microbiology, 2021)

Experimental investigation on dynamic mechanical characteristics and fracture mechanism of coal under repeated impact loads - Kai Wang; Guorui Feng; Tingye Qi; Jinwen Bai; Yujiang Zhang; Jun Guo; Cheng Song; Boqiang Cui (Arabian Journal of Geosciences, 2021)

In-Situ Seawater Gamma Spectrometry with LaBr3 Detector at a Nuclear Power Plant Outlet - Daowei Dou; Zhi Zeng; Wen Yu; Ming Zeng; Wu Men; Feng Lin; Hao Ma; Jianping Cheng; Junli Li (Journal of Marine Science and Engineering, 2021)
In a nuclear emergency, the application of in situ spectrometers for monitoring environmental radioactivity is significantly important, as information on the type and activity of radionuclides released from the accident can be obtained quickly. However, in emergency environmental radiological monitoring, a balance between energy resolution and detecting efficiency must be considered in selecting an appropriate detector. In this study, in situ gamma spectrometry was conducted with the LaBr3 detector to determine the radioactivity of seawater at the discharging outlet of a coastal nuclear power plant in southeast China. The results show that the LaBr3 scintillator has excellent energy resolution and detection efficiency, making it a promising detector for emergency monitoring.

Detection of Vestibular Schwannoma on Triple-parametric Magnetic Resonance Images Using Convolutional Neural Networks - Tzu-Hsuan Huang; Wei-Kai Lee; Chih-Chun Wu; Cheng-Chia Lee; Chia-Feng Lu; Huai-Che Yang; Chun-Yi Lin; Wen-Yuh Chung; Po-Shan Wang; Yen-Ling Chen; Hsiu-Mei Wu; Wan-You Guo; et al. (Journal of Medical and Biological Engineering, 2021)
Purpose The first step in typical treatment of vestibular schwannoma (VS) is to localize the tumor region, which is time-consuming and subjective because it relies on repeatedly reviewing different parametric magnetic resonance (MR) images. A reliable, automatic VS detection method can streamline the process. Methods A convolutional neural network architecture, namely YOLO-v2 with a residual network as a backbone, was used to detect VS tumors from MR images. To heighten performance, T1-weighted–contrast-enhanced, T2-weighted, and T1-weighted images were combined into triple-channel images for feature learning. The triple-channel images were cropped into three sizes to serve as input images of YOLO-v2. The VS detection effectiveness levels were evaluated for two backbone residual networks that downsampled the inputs by 16 and 32. Results The results demonstrated the VS detection capability of YOLO-v2 with a residual network as a backbone model. The average precision was 0.7953 for a model with 416 × 416-pixel input images and 16 instances of downsampling, when both the thresholds of confidence score and intersection-over-union were set to 0.5. In addition, under an appropriate threshold of confidence score, a high average precision, namely 0.8171, was attained by using a model with 448 × 448-pixel input images and 16 instances of downsampling. Conclusion We demonstrated successful VS tumor detection by using a YOLO-v2 with a residual network as a backbone model on resized triple-parametric MR images. The results indicated the influence of image size, downsampling strategy, and confidence score threshold on VS tumor detection.

N6-methyladenine DNA Demethylase ALKBH1 Regulates Mammalian Axon Regeneration - Qiao Li; Cheng Qian; Harry Feng; Tyger Lin; Qingsan Zhu; Ying Huang; Feng-Quan Zhou (Neuroscience Bulletin, 2021)

The Role of lncRNA TUG1 in the Parkinson Disease and Its Effect on Microglial Inflammatory Response - Jiang Cheng; Yangyang Duan; Fengting Zhang; Jin Shi; Hui Li; Feng Wang; Haining Li (NeuroMolecular Medicine, 2021)

Helios serves as a suppression marker to reduce regulatory T cell function in pancreatic cancer patients - Min-Feng Liu; Cheng Jin; Tao Wu; En-Hong Chen; Minxue Lu; Huan-Long Qin (Immunologic Research, 2021)

Oxidation of benzophenone-3 in aqueous solution by potassium permanganate: kinetics, degradation products, reaction pathways, and toxicity assessment - Wanming Cao; Nannan Wu; Ruijuan Qu; Cheng Sun; Zongli Huo; Jamaan S. Ajarem; Ahmed A. Allam; Zunyao Wang; Feng Zhu (Environmental Science and Pollution Research, 2021)

Quantitative characterization of horizontal well production performance with multiple indicators: a case study on the Weiyuan shale gas field in the Sichuan Basin, China - Rongze Yu; Wei Guo; Lin Ding; Meizhu Wang; Feng Cheng; Xiaowei Zhang; Shangwen Zhou; Leifu Zhang (Frontiers of Earth Science, 2021)

Near-Surface Geothermal Reservoir Imaging based on the Customized Dense Seismic Network - Changjiang Zhou; Jianghai Xia; Jingyin Pang; Feng Cheng; Xinhua Chen; Chaoqiang Xi; Hongyu Zhang; Ya Liu; Ling Ning; Tianyu Dai; Binbin Mi; Changwei Zhou (Surveys in Geophysics, 2021)

Paraventricular Nucleus P2X7 Receptors Aggravate Acute Myocardial Infarction Injury via ROS-Induced Vasopressin-V1b Activation in Rats - Wenjing Cheng; Yinggang Sun; Qin Wu; Kokwin Ooi; Yi Feng; Chunmei Xia; Danian Zhu (Neuroscience Bulletin, 2021)
The present study was designed to investigate the mechanisms by which P2X7 receptors (P2X7Rs) mediate the activation of vasopressinergic neurons thereby increasing sympathetic hyperactivity in the paraventricular nucleus (PVN) of the hypothalamus of rats with acute myocardial ischemia (AMI). The left anterior descending branch of the coronary artery was ligated to induce AMI in rats. The rats were pretreated with BBG (brilliant blue G, a P2X7R antagonist), nelivaptan (a vasopressin V1b receptor antagonist), or diphenyleneiodonium (DPI) [an nicotinamide adenine dinucleotide phosphate (NADPH) oxidase inhibitor]. Hemodynamic parameters of the heart were monitored. Myocardial injury and cardiomyocyte apoptosis were assessed. In the PVN of AMI rats, P2X7R mediated microglial activation, while reactive oxygen species (ROS) and NADPH oxidase 2 (NOX2) were higher than in the sham group. Intraperitoneal injection of BBG effectively reduced ROS production and vasopressin expression in the PVN of AMI rats. Moreover, both BBG and DPI pretreatment effectively reduced sympathetic hyperactivity and ameliorated AMI injury, as represented by reduced inflammation and apoptosis of cardiomyocytes. Furthermore, microinjection of nelivaptan into the PVN improved cardiac function and reduced the norepinephrine (AE) levels in AMI rats. Collectively, the results suggest that, within the PVN of AMI rats, P2X7R upregulation mediates microglial activation and the overproduction of ROS, which in turn activates vasopressinergic neuron-V1b receptors and sympathetic hyperactivity, hence aggravating myocardial injury in the AMI setting.

Experiments on granular flow behavior and deposit characteristics: implications for rock avalanche kinematics - Kun Li; Yu-Feng Wang; Qi-Wen Lin; Qian-Gong Cheng; Yue Wu (Landslides, 2021)

Genome-wide identification and expression analysis of the MADS-box transcription factor family in Camellia sinensis - Zai-Bao Zhang; Yuan-Jin Jin; Hou-Hong Wan; Lin Cheng; Zhi-Guo Feng (Journal of Applied Genetics, 2021)

Bi-allelic BRWD1 variants cause male infertility with asthenoteratozoospermia and likely primary ciliary dyskinesia - Ting Guo; Chao-Feng Tu; Dan-Hui Yang; Shui-Zi Ding; Cheng Lei; Rong-Chun Wang; Lv Liu; Xi Kang; Xiao-Qing Shen; Yi-Feng Yang; Zhi-Ping Tan; Yue-Qiu Tan; et al. (Human Genetics, 2021)

Establishment and characterization of 38 novel patient-derived primary cancer cell lines using multi-region sampling revealing intra-tumor heterogeneity of gallbladder carcinoma - Feiling Feng; Qingbao Cheng; Bin Li; Chen Liu; Huizhen Wang; Bin Li; Xiaoya Xu; Yong Yu; Zishuo Chen; Xiaobing Wu; Hua Dong; Kaijian Chu; et al. (Human Cell, 2021)
Gallbladder carcinoma (GBC) is a lethal biliary tract malignant neoplasm. Patient-derived primary cancer cell lines (PDPCs) are appropriate models to explore biological characteristics and potential therapeutics; however, there is a lack of PDPCs in GBC. In this study, we aimed to establish and characterize the GBC PDPCs, and further investigated the intra-tumor heterogeneity (ITH). Multi-region sampling (3–9 regions) of the operable tumor tissue samples was used to establish PDPCs. Short tandem repeat genotyping for cell authentication and karyotyping was performed, followed by whole-exome sequencing and RNA sequencing to assess the ITH at the genetic and transcriptional levels, respectively. Thirty-eight PDPCs were successfully established from seven GBC patients and characterized. ITH was observed with a median of 38.3% mutations being heterogeneous (range, 26.6–59.4%) across all patients. Similar with other tumor types, TP53 mutations were always truncal. In addition, there were three genes, KMT2C , CDKN2A , and ARID1A , with truncal mutations in at least two patients. A median of 370 differentially expressed genes (DEGs) was identified per patient. Distinct expression patterns were observed between major histocompatibility complex (MHC) class I and II genes. We found the expression of MHC class II genes in the PDPC samples was closely regulated by CIITA , while that of MHC class I genes were not correlated with CIITA expression. The PDPCs established from GBC patients can serve as novel in vitro models to identify the ITH, which may pave a crucial molecular foundation for enhanced understanding of tumorigenesis and progression.

Impact factors of the accumulation, migration and spread of antibiotic resistance in the environment - Zibo Lin; Tao Yuan; Lai Zhou; Sen Cheng; Xu Qu; Ping Lu; Qiyan Feng (Environmental Geochemistry and Health, 2021)

Detection and significance of exosomal mRNA expression profiles in the cerebrospinal fluid of patients with meningeal carcinomatosis - Peng Cheng; Feifei Feng; Hui Yang; Suqin Jin; Chao Lai; Yun Wang; Jianzhong Bi (Journal of Molecular Neuroscience, 2021)

Mechanism of colluvial landslide induction by rainfall and slope construction: A case study - Zhou Zhou; Jun-hui Shen; Ying Li; Wei-feng Duan; Ri-chang Yang; Jun-cheng Shu; He-wei Li; Sheng-yu Tao; Sheng-zhe Zheng (Journal of Mountain Science, 2021)

The molecular mechanism of a novel derivative of BTO-956 induced apoptosis in human myelomonocytic lymphoma cells - Yu-Lin Li; De-Jun Zhou; Zheng-Guo Cui; Lu Sun; Qian-Wen Feng; Shahbaz Ahmad Zakki; Yusuke Hiraku; Cheng-Ai Wu; Hidekuni Inadera (Apoptosis, 2021)

Improving Oral Bioavailability of Luteolin Nanocrystals by Surface Modification of Sodium Dodecyl Sulfate - Jiali Liu; Yongbing Sun; Meng Cheng; Qiaoming Liu; Wan Liu; Chao Gao; Jianfang Feng; Yi Jin; Liangxing Tu (AAPS PharmSciTech, 2021)

Optimization of Hexavalent Chromium Biosorption by Shewanella putrefaciens Using the Box-Behnken Design - Juan Cheng; Jingqi Gao; Jie Zhang; Wenjuan Yuan; Shiying Yan; Jie Zhou; Jian Zhao; Su Feng (Water, Air, & Soil Pollution, 2021)

An Insight into the Excavation-Induced Stress Paths on Mechanical Response of Weak Interlayer Zone in Underground Cavern Under High Geostress - Shu-Qian Duan; Quan Jiang; Guo-Feng Liu; Jie-Cheng Xiong; Po Gao; Ding-Ping Xu; Ming-Yu Li (Rock Mechanics and Rock Engineering, 2021)

Simulation of the fragmentation and propagation of jointed rock masses in rockslides: DEM modeling and physical experimental verification - Qi-wen Lin; Qian-Gong Cheng; Yu Xie; Feng-shou Zhang; Kun Li; Yu-feng Wang; Yuan-yuan Zhou (Landslides, 2021)

Phylogeny, recombination, and invasiveness of group B Streptococcus revealed by genomic comparisons of its global strains - Enze Lin; Shengmei Zou; Yue Wang; Chien-Chung Lee; Cheng-Hsun Chiu; Ye Feng (European Journal of Clinical Microbiology & Infectious Diseases, 2021)

Delayed association of acute particulate matter 2.5 air pollution exposure with loss of complexity in cardiac rhythm dynamics: insight from detrended fluctuation analysis - Tsung-Ying Tsai; Li-Wei Lo; Shin-Huei Liu; Wen-Han Cheng; Yu-Hui Chou; Wei-Lun Lin; Yenn-Jiang Lin; Shih-Lin Chang; Yu-Feng Hu; Fa-Po Chung; Jo-Nan Liao; Tze-Fan Chao; et al. (Environmental Science and Pollution Research, 2021)

A novel method for extraction of polypropylene microplastics in swine manure - Rui-Ting Wu; Ying-Feng Cai; Si-Cheng Xing; Yi-Wen Yang; Jian-Dui Mi; Xin-Di Liao (Environmental Science and Pollution Research, 2021)

Distribution and Assessment of Cr, Pb, Ni and Cd in Topsoil of the Modern Yellow River Delta, China - Hongjun Yang; Jingkuan Sun; Jiangbao Xia; Zhanyong Fu; Shuai Cheng; Tian Li; Pengshuai Shao; Kaikai Dong; Jinzhao Ma; Lu Feng (Wetlands, 2021)

Polyamine oxidase (PAO)–mediated polyamine catabolism plays potential roles in peach (Prunus persica L.) fruit development and ripening - Wei Wang; Xianbo Zheng; Shihao Liu; Bin Tan; Jun Cheng; Xia Ye; Jidong Li; Jiancan Feng (Tree Genetics & Genomes, 2021)

Small RNA Sequencing Analysis of Germinating Single-bud Seedcane Sett in Sugarcane - Kai-Chao Wu; Lin Xu; Zhi-Nian Deng; Tian Pang; Rong-Hua Zhang; Yi-Jie Li; Xiao-Yan Liu; Cheng-Feng Huang; Wen-Xian Qin; Jian-Feng Wei; Li-Ping Wei; Yang-Rui Li; et al. (Sugar Tech, 2021)

Carnosic acid alleviates depression-like behaviors on chronic mild stressed mice via PPAR-γ-dependent regulation of ADPN/FGF9 pathway - Xiao-qing Wang; Ya-hui Tang; Gui-rong Zeng; Li-feng Wu; Ying-jun Zhou; Ze-neng Cheng; De-Jian Jiang (Psychopharmacology, 2021)

ARF4 regulates shoot regeneration through coordination with ARF5 and IAA12 - Miao Miao Zhang; Huan Kai Zhang; Jun Feng Zhai; Xian Sheng Zhang; Ya Lin Sang; Zhi Juan Cheng (Plant Cell Reports, 2021)

Correction to: Kin17 facilitates thyroid cancer cell proliferation, migration, and invasion by activating p38 MAPK signaling pathway - Qun‑Guang Jiang; Cheng‑Feng Xiong; Yun‑Xia Lv (Molecular and Cellular Biochemistry, 2021)

Kin17 facilitates thyroid cancer cell proliferation, migration, and invasion by activating p38 MAPK signaling pathway - Qun-Guang Jiang; Cheng-Feng Xiong; Yun-Xia Lv (Molecular and Cellular Biochemistry, 2021)

Chronic Neck Pain Affects Shoulder Muscle Activity and Postural Control During Functional Reach - Cheng-Chieh Lin; Cheng-Feng Lin; Shiang-Hua Hua; Jen-Chieh Liao (Journal of Medical and Biological Engineering, 2021)

Effects of lithium resource exploitation on surface water at Jiajika mine, China - Juan-Qin Gao; Yang Yu; Deng-Hong Wang; Wei Wang; Cheng-Hui Wang; Hong-Zhang Dai; Xue-Feng Hao; Kuang Cen (Environmental Monitoring and Assessment, 2021)

Paracoccus lichenicola sp. nov., Isolated from Lichen - Lei Lang; De-Feng An; Long-Qian Jiang; Gui-Ding Li; Li-Song Wang; Xin-Yu Wang; Qin-Yuan Li; Cheng-Lin Jiang; Yi Jiang (Current Microbiology, 2021)

PapA , a peptidoglycan‐associated protein, interacts with OmpC and maintains cell envelope integrity - Yun‐Hao Wang; Hong‐He Chen; Zhou Huang; Xiao‐Jing Li; Nan Zhou; Chang Liu; Cheng‐Ying Jiang; De‐Feng Li; Shuang‐Jiang Liu (Environmental Microbiology, 2021)
Summary The bacterial cell envelope is critical to support and maintain cellular life. In Gram‐negative bacterial cells, the outer membrane and the peptidoglycan layer are two important parts of the cell envelope and they harbour abundant proteins. Here, we report the identification and characterization of a previously unknown p eptidoglycan‐ a ssociated p rotein, PapA, from the Gram‐negative Comamonas testosteroni . PapA bound peptidoglycan with its C‐terminal domain and interacted with the outer‐membrane porin OmpC. The PapA‐OmpC complex riveted the outer membrane and the peptidoglycan layer, and played a role in maintaining cell envelope integrity. When papA was disrupted, the mutant CNB‐1Δ papA apparently had an outer membrane partly separated from the peptidoglycan layer. Phenotypically, the mutant CNB‐1Δ papA lost chemotactic responses and had longer lag‐phase of growth, less flagellation and higher sensitivity to harsh environments. Totally, 1093 functionally unknown PapA homologues were identified from the public NR protein database and they were mainly distributed in Burkholderiales of Betaproteobacteria. Our finding provides a clue that the PapA homologous proteins might function as a rivet to maintain cell envelope integrity in those Gram‐negative bacteria.

The substrate‐dependent regulatory effects of the AfeI /R system in Acidithiobacillus ferrooxidans reveals the novel regulation strategy of quorum sensing in acidophiles - Xue‐Yan Gao; Chang‐Ai Fu; Likai Hao; Xiu‐Feng Gu; Rui Wang; Jian‐Qiang Lin; Xiang‐Mei Liu; Xin Pang; Cheng‐Jia Zhang; Jian‐Qun Lin; Lin‐Xu Chen (Environmental Microbiology, 2021)
Summary A LuxI/R‐like quorum sensing (QS) system (AfeI/R) has been reported in the acidophilic and chemoautotrophic Acidithiobacillus spp. However, the function of AfeI/R remains unclear because of the difficulties in the genetic manipulation of these bacteria. Here, we constructed different afeI mutants of the sulfur‐ and iron‐oxidizer A . ferrooxidans , identified the N‐acyl homoserine lactones (acyl‐HSLs) synthesized by AfeI, and determined the regulatory effects of AfeI/R on genes expression, extracellular polymeric substance synthesis, energy metabolism, cell growth and population density of A . ferrooxidans in different energy substrates. Acyl‐HSLs‐mediated distinct regulation strategies were employed to influence bacterial metabolism and cell growth of A . ferrooxidans cultivated in either sulfur or ferrous iron. Based on these findings, an energy‐substrate‐dependent regulation mode of AfeI/R in A . ferrooxidans was illuminated that AfeI/R could produce different types of acyl‐HSLs and employ specific acyl‐HSLs to regulate specific genes in response to different energy substrates. The discovery of the AfeI/R‐mediated substrate‐dependent regulatory mode expands our knowledge on the function of QS system in the chemoautotrophic sulfur‐ and ferrous iron‐oxidizing bacteria, and provides new insights in understanding energy metabolism modulation, population control, bacteria‐driven bioleaching process, and the coevolution between the acidophiles and their acidic habitats.

Sesquiterpenoids and meroterpenoids from a mangrove derived fungus Diaporthe sp. SCSIO 41011 - Xiao-Wei Luo; Chun-Mei Chen; Kun-Long Li; Xiu-Ping Lin; Cheng-Hai Gao; Xue-Feng Zhou; Yong-Hong Liu (Natural Product Research, 2021)

Comparison of the Nutritional Quality of Three Edible Tissues from Precocious and Normal Adult Female Chinese Mitten Crabs ( Eriocheir sinensis ) - Huafeng Cheng; Haoran Wu; Feng Liang; Mengtian Ge; Shaotong Jiang; Lin Lin; Jianfeng Lu (Journal of Aquatic Food Product Technology, 2021)

Construction and characterization of UAA-controlled recombinant Zika virus by genetic code expansion - Rong-Rong Zhang; Qing Ye; Xiao-Feng Li; Yong-Qiang Deng; Yan-Peng Xu; Xing-Yao Huang; Qing Xia; Cheng-Feng Qin (Science China Life Sciences, 2021)

Effects of Different Component Contents of Colistin Methanesulfonate on the Pharmacokinetics of Prodrug and Formed Colistin in Human - Ya-Xin Fan; Yuan-Cheng Chen; Yi Li; Ji-Cheng Yu; Xing-Chen Bian; Xin Li; Wan-Zhen Li; Bei-Ning Guo; Hai-Lan Wu; Xiao-Fen Liu; Yu Wang; Xiao-Yong Xu; et al. (Pharmaceutical Research, 2021)

Allicin can suppress the activity of vascular endothelial cells probably by regulating JAK2/STAT3 pathway - Hui-Hui Sun; Xin-Min Feng; Jing-Cheng Wang; Jun Cai (Molecular and Cellular Biochemistry, 2021)

Interannual variability of the spring Wyrtki Jet - Kangping Deng; Xuhua Cheng; Tao Feng; Tian Ma; Wei Duan; Jiajia Chen (Journal of Oceanology and Limnology, 2021)

Characterization of a recombinant sucrose isomerase and its application to enzymatic production of isomaltulose - Feng Zhang; Feng Cheng; Dong-Xu Jia; Yue-Hao Gu; Zhi-Qiang Liu; Yu-Guo Zheng (Biotechnology Letters, 2021)

Mechanism of TonB-dependent transport system in Halomonas alkalicola CICC 11012s in response to alkaline stress - Lei Zhai; Jiuyan Xie; Huijun Feng; Sijia Sun; Kun Cheng; Su Yao (Extremophiles, 2021)

Improving the observation and prediction capabilities for Arctic marine environment: from the perspective of Arctic Shipping - Hui Wang; Qizhen Sun; Lin Zhang; Xi Liang; Qinghua Yang; Na Liu; Chunhua Li; Qingsheng Liu; Bingrui Li; Qian Feng; Xiao Cheng; Yi Yu (Acta Oceanologica Sinica, 2021)

Concurrent increases in post-pacing action potential duration and contractility predict occurrence of ventricular arrhythmia - Chih-Min Liu; Feng-Zhi Lin; Yao-Chang Chen; Yung-Kuo Lin; Yen-Yu Lu; Cheng-I Wu; Satoshi Higa; Shih-Ann Chen; Yi-Jen Chen (Pflügers Archiv - European Journal of Physiology, 2020)

Drought monitoring in Yunnan Province based on a TRMM precipitation product - Yuanhe Yu; Jinliang Wang; Feng Cheng; Huan Deng; Sheng Chen (Natural Hazards, 2020)

Doxorubicin metabolism moderately attributes to putative toxicity in prodigiosin/doxorubicin synergism in vitro cells - Shian-Ren Lin; Chun-Shu Lin; Ching-Cheng Chen; Feng-Jen Tseng; Tsung-Jui Wu; Lebin Weng; Ching-Feng Weng (Molecular and Cellular Biochemistry, 2020)
Doxorubicin (Dox) is a widely neoplasm chemotherapeutic drug with high incidences of cardiotoxicity. Prodigiosin (PG), a red bacterial pigment from Serratia marcescens , has been demonstrated to potentiate Dox’s cytotoxicity against oral squamous cell carcinoma cells through elevating Dox influx and identified as a Dox enhancer via PG-induced autophagy; however, toxicity of normal cell remains unclear. This study is conducted to evaluate putative cytotoxicity features of PG/Dox synergism in the liver, kidney, and heart cells and further elucidate whether PG augmented Dox’s effect via modulating Dox metabolism in normal cells. Murine hepatocytes FL83B, cardio-myoblast h9c2, and human kidney epithelial cells HK-2 were sequentially treated with PG and Dox by measuring cell viability, cell death characteristics, oxidative stress, Dox flux, and Dox metabolism. PG could slightly significant increase Dox cytotoxicity in all tested normal cells whose toxic alteration was less than that of oral squamous carcinoma cells. The augmentation of Dox cytotoxicity might be attributed to the increase of Dox-mediated ROS accumulation that might cause slight reduction of Dox influx and reduction of Dox metabolism. It was noteworthy to notice that sustained cytotoxicity appeared in normal cells after PG and Dox were removed. Taken together, moderately metabolic reduction of Dox might be ascribed to the mechanism of increase Dox cytotoxicity in PG-induced normal cells; nevertheless, the determination of PG/Dox dose with sustained cytotoxicity in normal cells needs to be comprehensively considered.

A review of the impact of outdoor and indoor environmental factors on human health in China - Yuxia Ma; Yifan Zhang; Bowen Cheng; Fengliu Feng; Haoran Jiao; Xiaoyan Zhao; Bingji Ma; Zhiang Yu (Environmental Science and Pollution Research, 2020)

Variability in the global energy budget and transports 1985–2017 - Chunlei Liu; Richard P. Allan; Michael Mayer; Patrick Hyder; Damien Desbruyères; Lijing Cheng; Jianjun Xu; Feng Xu; Yu Zhang (Climate Dynamics, 2020)
The study of energy flows in the Earth system is essential for understanding current climate change. To understand how energy is accumulating and being distributed within the climate system, an updated reconstruction of energy fluxes at the top of atmosphere, surface and within the atmosphere derived from observations is presented. New satellite and ocean data are combined with an improved methodology to quantify recent variability in meridional and ocean to land heat transports since 1985. A global top of atmosphere net imbalance is found to increase from 0.10 ± 0.61 W m −2 over 1985–1999 to 0.62 ± 0.1 W m −2 over 2000–2016, and the uncertainty of ± 0.61 W m −2 is related to the Argo ocean heat content changes (± 0.1 W m −2 ) and an additional uncertainty applying prior to 2000 relating to homogeneity adjustments. The net top of atmosphere radiative flux imbalance is dominated by the southern hemisphere (0.36 ± 0.04 PW, about 1.41 ± 0.16 W m −2 ) with an even larger surface net flux into the southern hemisphere ocean (0.79 ± 0.16 PW, about 3.1 ± 0.6 W m −2 ) over 2006–2013. In the northern hemisphere the surface net flux is of opposite sign and directed from the ocean toward the atmosphere (0.44 ± 0.16 PW, about 1.7 ± 0.6 W m −2 ). The sea ice melting and freezing are accounted for in the estimation of surface heat flux into the ocean. The northward oceanic heat transports are inferred from the derived surface fluxes and estimates of ocean heat accumulation. The derived cross-equatorial oceanic heat transport of 0.50 PW is higher than most previous studies, and the derived mean meridional transport of 1.23 PW at 26° N is very close to 1.22 PW from RAPID observation. The surface flux contribution dominates the magnitude of the oceanic transport, but the integrated ocean heat storage controls the interannual variability. Poleward heat transport by the atmosphere at 30° N is found to increase after 2000 (0.17 PW decade −1 ). The multiannual mean (2006–2013) transport of energy by the atmosphere from ocean to land is estimated as 2.65 PW, and is closely related to the ENSO variability.

Identification of immune-related gene signature predicting survival in the tumor microenvironment of lung adenocarcinoma - Mengnan Zhao; Ming Li; Zhencong Chen; Yunyi Bian; Yuansheng Zheng; Zhengyang Hu; Jiaqi Liang; Yiwei Huang; Jiacheng Yin; Cheng Zhan; Mingxiang Feng; Qun Wang (Immunogenetics, 2020)

Improved Brassica oleracea JZS assembly reveals significant changing of LTR-RT dynamics in different morphotypes - Xu Cai; Jian Wu; Jianli Liang; Runmao Lin; Kang Zhang; Feng Cheng; Xiaowu Wang (Theoretical and Applied Genetics, 2020)

WDR5a functions in cadmium-inhibited root meristem growth by regulating nitric oxide accumulation in Arabidopsis - Yu Zhang; Yang-Yang Tian; Lin-Feng Wang; Yun-Hui Li; Ting-Ting Li; Wen-Cheng Liu (Planta, 2020)

The effect of blastomere loss during frozen embryo transfer on the transcriptome of offspring’s umbilical cord blood - Yan-Ting Wu; Ze-Han Dong; Cheng Li; Dai-Zhan Zhou; Jun-Yu Zhang; Yan Wu; Jing-Jing Xu; Yu Wang; Xiao-Qun Ye; Jian-Zhong Sheng; Li Wang; He-Feng Huang (Molecular Biology Reports, 2020)

Observation system simulation experiments using an ensemble-based method in the northeastern South China Sea - Wu Geng; Feng Cheng; Qiang Xie; Xiaoli Zou; Weihong He; Zhaozheng Wang; Yeqiang Shu; Gengxin Chen; Danian Liu; Dong Ye; Ruiwen Wang; Chuanyu Liu (Journal of Oceanology and Limnology, 2020)

How do Biotic and Abiotic Factors Regulate Soil Enzyme Activities at Plot and Microplot Scales Under Afforestation? - Qianxi Li; Ji Chen; Jiao Feng; Junjun Wu; Qian Zhang; Wei Jia; Qiaoling Lin; Xiaoli Cheng (Ecosystems, 2020)

Characterization of a Protease Hyper-Productive Mutant of Bacillus pumilus by Comparative Genomic and Transcriptomic Analysis - Yong-Cheng Liu; Lin-Li Han; Tian-Yu Chen; Yan-Bing Lu; Hong Feng (Current Microbiology, 2020)

A calculation model to assess the crack propagation length of rock block in clastic flow - Yang Liu; Yong You; Jin-feng Liu; Shu-xi Zhao; Dong-xu Yang; Dao-chuan Liu; Lin Liu; Yan-fang Xie; Kai-cheng Yang (Journal of Mountain Science, 2020)

Prevalence of Clonorchis sinensis infection in fish in South‐East Asia: A systematic review and meta‐analysis - Ying Zhang; Qing‐Long Gong; Qing‐Bo Lv; Yang‐Yuan Qiu; Yan‐Chun Wang; Hong‐Yu Qiu; Xin‐Rui Guo; Jun‐Feng Gao; Qiao‐Cheng Chang; Chun‐Ren Wang (Journal of Fish Diseases, 2020)
Clonorchis sinensis , an important fish‐borne zoonotic trematode, is widely distributed in South‐East Asia, especially in China. Infections from human and animal reservoir hosts occur due to the consumption of raw or undercooked fish with C. sinensis metacercariae. This study aimed to evaluate the prevalence of C. sinensis metacercariae in fish in South‐East Asia via systematic review and meta‐analysis. We searched PubMed, ScienceDirect, China National Knowledge Infrastructure, Wanfang and Chongqing VIP databases for studies published between 1976 and 2020 that are related to the prevalence of C. sinensis metacercariae in fish. Studies were screened with keywords based on inclusion and exclusion criteria. Seventy‐one eligible articles were identified, covering three countries: China, Korea and Vietnam. The pooled prevalence of C. sinensis metacercariae in fish from South‐East Asia was 30.5%, with 35.1% in China, 29.7% in Korea and 8.4% in Vietnam. In subgroup analyses of climate, season, water source and publication date, the highest prevalence was identified in the Dwb climate type (43.3%), summer (70.2%), river (34.5%) and pre‐2001 publications (38.9%), respectively. In comparison, the lowest prevalence was found in the Dfa climate type (14.5%), winter (19.5%), lake (8.0%) and post‐2001 publications (23.8%). Meta‐regression results indicated that country ( p = .009), the published time ( p = .035) and water source subgroups ( p = .003) may be the source of heterogeneity. Overall, our study indicates that a high prevalence of C. sinensis infections occurs in fish in China, Korea and Vietnam, illuminating a significant public health concern in these countries.

The mechanism of EAP-EU combined impact on summer rainfall over North Asia - Po Hu; Jianbo Cheng; Guolin Feng; Muhammad Mubashar Ahmad Dogar; Zhiqiang Gong (Theoretical and Applied Climatology, 2020)

Chronic minocycline treatment exerts antidepressant effect, inhibits neuroinflammation, and modulates gut microbiota in mice - Qi Yang; Li Luo; Ting Sun; Le Yang; Li-Fei Cheng; Yan Wang; Qing-Qing Liu; An Liu; Hai-Yan Liu; Ming-Gao Zhao; Sheng-Xi Wu; Bin Feng (Psychopharmacology, 2020)

Liquiritin inhibits proliferation and induces apoptosis in HepG2 hepatocellular carcinoma cells via the ROS-mediated MAPK/AKT/NF-κB signaling pathway - Jia-Ru Wang; Tian-Zhu Li; Cheng Wang; Shu-Mei Li; Ying-Hua Luo; Xian-Ji Piao; Yu-Chao Feng; Yi Zhang; Wan-Ting Xu; Yu Zhang; Tong Zhang; Shi-Nong Wang; et al. (Naunyn-Schmiedeberg's Archives of Pharmacology, 2020)

The anti-inflammatory drug dimethyl itaconate protects against colitis-associated colorectal cancer - Qian Wang; Xin Ling Li; Yan Mei; Jia-Chong Ye; Wei Fan; Guang-Hui Cheng; Mu-Sheng Zeng; Guo-Kai Feng (Journal of Molecular Medicine, 2020)

Overexpression of PREX1 in oral squamous cell carcinoma indicates poor prognosis - Shu-Cheng Wan; Hao Wu; Hao Li; Wei-Wei Deng; Yao Xiao; Cong-Cong Wu; Lei-Lei Yang; Wen-Feng Zhang; Zhi-Jun Sun (Journal of Molecular Histology, 2020)

Short-term effect of extreme air temperature on hospital emergency room visits for cardiovascular diseases from 2009 to 2012 in Beijing, China - Yuxia Ma; Haoran Jiao; Yifan Zhang; Fengliu Feng; Bowen Cheng; Bingji Ma; Zhiang Yu (Environmental Science and Pollution Research, 2020)

2(5H)-Furanone Disrupts Bacterial Biofilm Formation and Indirectly Reduces the Settlement of Plantigrades of the Mussel Mytilus coruscus - Yi-Feng Li; Xin Zhu; Zhi-Yang Cheng; Xiao Liang; You-Ting Zhu; Dan-Dan Feng; Sergey Dobretsov; Jin-Long Yang (Frontiers in Marine Science, 2020)

Archaeobotanical evidence reveals the human–environment interactions during the 9th–13th centuries at Turpan, Xinjiang on the ancient Silk Road - Yi-Feng Yao; Xia Wang; Wu Guo; Hong-En Jiang; Min Li; David K. Ferguson; Yu-Fei Wang; Cheng-Sen Li (Vegetation History and Archaeobotany, 2020)

Comparing GWAS and Brain Structure-Specific Gene Expression Profiles Identifies Psychiatric Disorder-Related Brain Structures at Different Developmental Stages - Xin Qi; Cuiyan Wu; Yanan Du; Shiqiang Cheng; Yan Wen; Mei Ma; Chujun Liang; Li Liu; Bolun Cheng; Lu Zhang; Ping Li; Feng Zhang (Neuroscience Bulletin, 2020)

Alpinia oxyphylla–Schisandra chinensis Herb Pair Alleviates Amyloid-β Induced Cognitive Deficits via PI3K/Akt/Gsk-3β/CREB Pathway - Yu Qi; Huiting Jing; Xinhui Cheng; Tingxu Yan; Feng Xiao; Bo Wu; Kaishun Bi; Ying Jia (NeuroMolecular Medicine, 2020)

Correction to: Long non-coding RNA H19 promotes osteogenic differentiation of renal interstitial fibroblasts through Wnt-β-catenin pathway - Zewu Zhu; Yu Cui; Fang Huang; Huimin Zeng; Weiping Xia; Feng Zeng; Cheng He; Jinbo Chen; Zhiyong Chen; Hequn Chen; Yang Li (Molecular and Cellular Biochemistry, 2020)

Lacustrine record from the eastern Tibetan Plateau associated with Asian summer monsoon changes over the past ~ 6 ka and its links with solar and ENSO activity - Guodong Ming; Weijian Zhou; Peng Cheng; Hong Wang; Feng Xian; Yunchong Fu; Shugang Wu; Hua Du (Climate Dynamics, 2020)

Shake table testing and computational investigation of the seismic performance of modularized suspended building systems - Zhihang Ye; Gang Wu; De-Cheng Feng; Abdollah Shafieezadeh (Bulletin of Earthquake Engineering, 2020)

Genesis of the Linghu Au deposit in Xiaoqinling Region, Henan province, China: Constraints from fluid inclusions and isotope systematics - Wei Zeng; Zhi-gao Wang; Duo Wan; Feng-yue Sun; Cheng-dong Li; Reng-an Yu; Jia-ying Wang; Jian-chang Xu (Arabian Journal of Geosciences, 2020)

A new phenanthropyran and a new biphenanthrene from the rhizomes of Dioscorea septemloba and their antioxidant activities - Tao He; Yi Liu; Rui-Feng Xiong; Xiao-Yu Li; Shou-Feng Wang; Chun-Ru Cheng (Natural Product Research, 2020)

Selective mGluR1 Negative Allosteric Modulator Reduces Blood–Brain Barrier Permeability and Cerebral Edema After Experimental Subarachnoid Hemorrhage - Cheng Zhang; Ming Jiang; Wei-qi Wang; Shi-jun Zhao; Yan-xin Yin; Qiong-jie Mi; Ming-feng Yang; Yu-qiang Song; Bao-liang Sun; Zong-yong Zhang (Translational Stroke Research, 2020)

On the discrepancies in the changes in the annual mean Hadley circulation among different regions and between CMIP5 models and reanalyses - Jianbo Cheng; Shujuan Hu; Chenbin Gao; Xiaoya Hou; Zhihang Xu; Guolin Feng (Theoretical and Applied Climatology, 2020)

Nakamurella albus sp. nov.: A Novel Actinobacterium Isolated from a Lichen Sample - Long-Qian Jiang; De-Feng An; Kun Zhang; Gui-Ding Li; Xin-Yu Wang; Lei Lang; Ming-Guo Jiang; Li-Song Wang; Cheng-Lin Jiang; Yi Jiang (Current Microbiology, 2020)

Naphthalene exerts non-target effects on the abundance of active fungi by stimulating basidiomycete abundance - Li-ying Lan; Li Zhang; Ya Shen; Jian Zhang; Wan-qin Yang; Zhen-feng Xu; Yang Liu; Shu-qin He; Wei Zhou; Han Li; Li-xia Wang; Si-ning Liu; et al. (Journal of Mountain Science, 2020)

Deep-hole in situ stress measurement method in high-altitude area based on remote sensing technology - Cheng Qin; Feng Xu; Yudong Zhang; Pinqing Yang; Lei Pan; Gongbin Yan (Arabian Journal of Geosciences, 2020)

The trichome-specific acetolactate synthase NtALS1 gene, is involved in acylsugar biosynthesis in tobacco (Nicotiana tabacum L.) - Ai-Xia Chang; Biao Chen; Ai-Guo Yang; Ri-Sheng Hu; Quan-Fu Feng; Ming Chen; Xiao-Ning Yang; Cheng-Gang Luo; Yang-Yang Li; Yuan-Ying Wang (Planta, 2020)

Contrasting soil C and N dynamics inferred from δ13C and δ15N values along a climatic gradient in southern China - Jiao Feng; Fan Yang; Junjun Wu; Qiong Chen; Qian Zhang; Xiaoli Cheng (Plant and Soil, 2020)

Long non-coding RNA H19 promotes osteogenic differentiation of renal interstitial fibroblasts through Wnt-β-catenin pathway - Zewu Zhu; Yu Cui; Fang Huang; Huimin Zeng; Weiping Xia; Feng Zeng; Cheng He; Jinbo Chen; Zhiyong Chen; Hequn Chen; Yang Li (Molecular and Cellular Biochemistry, 2020)

Role of Magnesium in Type 2 Diabetes Mellitus - Jianan Feng; Heyuan Wang; Zhe Jing; Yue Wang; Yanli Cheng; Wanning Wang; Weixia Sun (Biological Trace Element Research, 2020)

Estimation of oil saturation via pseudo capillary pressure curve from nuclear magnetic resonance log data in tight conglomerate reservoirs - Yong Song; Cheng Feng; Zhenlin Wang; Zhongchun Sun (Arabian Journal of Geosciences, 2020)

Long interpregnancy interval and adverse perinatal outcomes: A retrospective cohort study - Jing Lin; Han Liu; Dan-Dan Wu; Hong-Tao Hu; Hui-Hui Wang; Cheng-Liang Zhou; Xin-Mei Liu; Xiao-Jun Chen; Jian-Zhong Sheng; He-Feng Huang (Science China Life Sciences, 2020)

Lactobacillus rhamnosus GG and Bifidobacterium bifidum TMC3115 Can Affect Development of Hippocampal Neurons Cultured In Vitro in a Strain-Dependent Manner - Ruyue Cheng; Tong Xu; Yujie Zhang; Feng Wang; Linsen Zhao; Yugang Jiang; Fang He (Probiotics and Antimicrobial Proteins, 2020)