Uncertainties Associated With Simulating Regional Sea Surface Height and Tides: A Case Study of the East China Seas - Long Jiang; Xinyu Lu; Wenlong Xu; Peng Yao; Xuhua Cheng (Frontiers in Marine Science, 2022)
Modeling sea surface height (SSH) and tides is important but challenging in shelf seas. The Eastern China Seas (ECSs) is such a shelf sea with large inter-model deviations in prior studies. In order to assess and compare the possible uncertainty sources, numerical scenarios of varying the open boundary forcing, bottom roughness length scale, atmospheric forcing, grid resolution, and regional bathymetry were conducted in a hydrodynamic model of the ECSs. Results indicate that bathymetry data and open boundary forcing with inadequate accuracy generate uncertainties in SSH and tides locally and throughout the basin. An increase in bottom roughness enhances tidal dissipation and shifts amphidromes to the left relative to the incoming Kelvin waves, causing SSH variations in the ECSs. Refining the model resolution from 4 to 2 km mainly affects nearshore SSH and tides due to minor changes in depicted coastlines. Using different reanalysis meteorological data appears more important on the episodic than annual scale. It is highlighted that some uncertainty sources have opposing effects on SSH or tides and counteract their individual biases, making it difficult to achieve a realistic simulation. For example, increasing bottom roughness can not only compensate effects of overestimated tidal amplitude at open boundaries, but also balance out the overestimated M2 phase along the West Coast of Korea in a coarser-resolution model. Based on findings in this study, suggestions are provided for further reducing uncertainties in SSH and tide modeling in the ECSs and other shelf seas.

One-Time Root-Zone Nitrogen Fertilisation Allows High Yields and Labour Savings During Oilseed Rape Production in the Yangtze River Delta Region of China - Liang Cheng; Huoyan Wang; Dianjun Lu; Xiaoqin Chen (Journal of Soil Science and Plant Nutrition, 2022)

CAV1 is a prognostic predictor for patients with idiopathic pulmonary fibrosis and lung cancer - Dongdong Yin; Jiayang Qiu; Suxia Hu; Longqiang Cheng; Hui Li; Xingpu Cheng; Shun Wang; Jun Lu (Journal of Biosciences, 2022)

Photocatalytic degradation of imidacloprid by optimized Bi2WO6/NH2-MIL-88B(Fe) composite under visible light - Mao-Long Chen; Tian-Hui Lu; Shan-Shan Li; Li Wen; Zhou Xu; Yun-Hui Cheng (Environmental Science and Pollution Research, 2022)

Combined toxicity of polystyrene microplastics and sulfamethoxazole on zebrafish embryos - Jiarui Lu; Jie Wu; Lulin Gong; Yuan Cheng; Qingbin Yuan; Yide He (Environmental Science and Pollution Research, 2022)

Effects of extreme precipitation on hospitalization risk and disease burden of schizophrenia in urban and rural Lu’an, China, from 2010 to 2019 - Yudong Wu; Zhenghai Yao; Gongyan Ma; Jian Cheng; Huabin Xu; Wei Qin; Weizhuo Yi; Rubing Pan; Qiannan Wei; Chao Tang; Xiangguo Liu; Yangyang He; et al. (Environmental Science and Pollution Research, 2022)

MoOpy2 is essential for fungal development, pathogenicity, and autophagy in Magnaporthe oryzae - Ying‐Ying Cai; Jing‐Yi Wang; Xi‐Yu Wu; Shuang Liang; Xue‐Ming Zhu; Lin Li; Jian‐Ping Lu; Xiao‐Hong Liu; Fu‐Cheng Lin (Environmental Microbiology, 2022)
Summary The development and pathogenicity of the fungus Magnaporthe oryzae , the causal agent of destructive rice blast disease, require it to perceive external environmental signals. Opy2, an overproduction‐induced pheromone‐resistant protein 2, is a crucial protein for sensing external signals in Saccharomyces cerevisiae . However, the biological functions of the homologue of Opy2 in M. oryzae are unclear. In this study, we identified that MoOPY2 is involved in fungal development, pathogenicity, and autophagy in M. oryzae . Deletion of MoOPY2 resulted in pleiotropic defects in hyphal growth, conidiation, germ tube extension, appressorium formation, appressorium turgor generation, and invasive growth, therefore leading to attenuated pathogenicity. Furthermore, MoOpy2 participates in the Osm1 MAPK pathway and the Mps1 MAPK pathway by interacting with the adaptor protein Mst50. The interaction sites of Mst50 and MoOpy2 colocalized with the autophagic marker protein MoAtg8 in the preautophagosomal structure sites (PAS). Notably, the Δ Moopy2 mutant caused cumulative MoAtg8 lipidation and rapid GFP‐MoAtg8 degradation in response to nitrogen starvation, showing that MoOpy2 is involved in the negative regulation of autophagy activity. Taken together, our study revealed that MoOpy2 of M. oryzae plays an essential role in the orchestration of fungal development, appressorium penetration, autophagy and pathogenesis.

Endosomal sorting complexes required for transport‐0 ( ESCRT ‐0) are essential for fungal development, pathogenicity, autophagy and ER ‐phagy in Magnaporthe oryzae - Li‐Xiao Sun; Hui Qian; Meng‐Yu Liu; Ming‐Hua Wu; Yun‐Yun Wei; Xue‐Ming Zhu; Jian‐Ping Lu; Fu‐Cheng Lin; Xiao‐Hong Liu (Environmental Microbiology, 2022)
Summary Magnaporthe oryzae is an important plant pathogen that causes rice blast. Hse1 and Vps27 are components of ESCRT‐0 involved in the multivesicular body (MVB) sorting pathway and biogenesis. To date, the biological functions of ESCRT‐0 in M. oryzae have not been determined. In this study, we identified and characterized Hse1 and Vps27 in M. oryzae . Disruption of MoHse1 and MoVps27 caused pleiotropic defects in growth, conidiation, sexual development and pathogenicity, thereby resulting in loss of virulence in rice and barley leaves. Disruption of MoHse1 and MoVps27 triggered increased lipidation of MoAtg8 and degradation of GFP‐MoAtg8, indicating that ESCRT‐0 is involved in the regulation of autophagy. ESCRT‐0 was determined to interact with coat protein complex II (COPII), a regulator functioning in homeostasis of the endoplasmic reticulum (ER homeostasis), and disruption of MoHse1 and MoVps27 also blocked activation of the unfolded protein response (UPR) and autophagy of the endoplasmic reticulum (ER‐phagy). Overall, our results indicate that ESCRT‐0 plays critical roles in regulating fungal development, virulence, autophagy and ER‐phagy in M. oryzae .

Phylogeography and Genetic Structure of the Swimming Crabs Portunus sanguinolentus (Herbst, 1783) in East Asia - Yu-Ming Lu; Chun-Han Shih; Po-Cheng Chen; Wei-Chieh Kao; Ying-Chou Lee; Yu-San Han; Tzong-Der Tzeng (Journal of Marine Science and Engineering, 2022)
The three-spot swimming crab (Portunus sanguinolentus) is mainly distributed in South East Asia. An analysis of mitochondrial control region partial sequences allows us to determine the population genetic structure, phylogeography and historical demography of this species in East Asia. The seven populations, which included 110 individuals, were collected from mainland China (Shanghai, SH, Xiamen, XM and Hong Kong, HK), Taiwan (Yilan, YL, Taichung, TC, Donggang, DG) and Singapore (Singapore, SGP). The nucleotide diversity (π) of all individuals was 0.01149, with values ranging from 0.00372 (SGP) to 0.01345 (YL). In total, 90 haplotypes have been identified, which can be divided into two major lineages: lineage A consists of specimens from SH, YL, XM, TC and DG, and lineage B corresponds to specimen from SGP. From the second to the most recent interglacial period, population expansion was observed in each lineage. However, a low level of genetic differentiation was also observed in the three-spotted swimming crab, P. sanguinolentus, according to FST values. Our results suggest that several past and present habitat configurations have shaped the genetic patterns of P. sanguinolentus until now. During Pleistocene glaciations, when sea levels were low, this species may have moved along the coast from Southeast Asia to China. It first colonized the Hong Kong area during this era. After sea levels rose and shorelines receded, it subsequently spread to the coast of mainland China.

An autopolyploid-suitable polyBSA-seq strategy for screening candidate genetic markers linked to leaf blight resistance in sugarcane - Zhoutao Wang; Hui Ren; Chao Pang; Guilong Lu; Fu Xu; Wei Cheng; Youxiong Que; Liping Xu (Theoretical and Applied Genetics, 2022)

Downregulated Calcium-Binding Protein S100A16 and HSP27 in Placenta-Derived Multipotent Cells Induce Functional Astrocyte Differentiation - Yu-Che Cheng; Chi-Jung Huang; Wei-Chi Ku; Shu-Lin Guo; Lu-Tai Tien; Yih-Jing Lee; Chih-Cheng Chien (Stem Cell Reviews and Reports, 2022)
Little is known about genes that induce stem cells differentiation into astrocytes. We previously described that heat shock protein 27 (HSP27) downregulation is directly related to neural differentiation under chemical induction in placenta-derived multipotent stem cells (PDMCs). Using this neural differentiation cell model, we cross-compared transcriptomic and proteomic data and selected 26 candidate genes with the same expression trends in both omics analyses. Those genes were further compared with a transcriptomic database derived from Alzheimer’s disease (AD). Eighteen out of 26 candidates showed opposite expression trends between our data and the AD database. The mRNA and protein expression levels of those candidates showed downregulation of HSP27, S100 calcium-binding protein A16 (S100A16) and two other genes in our neural differentiation cell model. Silencing these four genes with various combinations showed that co-silencing HSP27 and S100A16 has stronger effects than other combinations for astrocyte differentiation. The induced astrocyte showed typical astrocytic star-shape and developed with ramified, stringy and filamentous processes as well as differentiated endfoot structures. Also, some of them connected with each other and formed continuous network. Immunofluorescence quantification of various neural markers indicated that HSP27 and S100A16 downregulation mainly drive PDMCs differentiation into astrocytes. Immunofluorescence and confocal microscopic images showed the classical star-like shape morphology and co-expression of crucial astrocyte markers in induced astrocytes, while electrophysiology and Ca 2+ influx examination further confirmed their functional characteristics. In conclusion, co-silencing of S100A16 and HSP27 without chemical induction leads to PDMCs differentiation into functional astrocytes. Graphical abstract

Cancer metabolism and tumor microenvironment: fostering each other? - Yiyuan Yuan; Huimin Li; Wang Pu; Leilei Chen; Dong Guo; Hongfei Jiang; Bo He; Siyuan Qin; Kui Wang; Na Li; Jingwei Feng; Jing Wen; et al. (Science China Life Sciences, 2022)

Fuzzy Forest Machine Learning Predictive Model for Mineral Prospectivity: A Case Study on Southwest Indian Ridge 48.7°E–50.5°E - Lushi Liu; Jilong Lu; Chunhui Tao; Shili Liao; Cheng Su; Nan Huang; Xing Xu (Natural Resources Research, 2022)

Evolutionary dynamics and conserved function of the Tudor domain-containing (TDRD) proteins in teleost fish - Zeyu Liu; Saisai Liu; Shiyang Guo; Wei Lu; Quanqi Zhang; Jie Cheng (Marine Life Science & Technology, 2022)

Structure modification, antialgal, antiplasmodial, and toxic evaluations of a series of new marine-derived 14-membered resorcylic acid lactone derivatives - Wei-Feng Xu; Na-Na Wu; Yan-Wei Wu; Yue-Xuan Qi; Mei-Yan Wei; Laura M. Pineda; Michelle G. Ng; Carmenza Spadafora; Ji-Yong Zheng; Ling Lu; Chang-Yun Wang; Yu-Cheng Gu; et al. (Marine Life Science & Technology, 2022)
Marine natural products play critical roles in the chemical defense of many marine organisms and are essential, reputable sources of successful drug leads. Sixty-seven 14-membered resorcylic acid lactone derivatives 3 – 27 and 30 – 71 of the natural product zeaenol ( 1 ) isolated from the marine-derived fungus Cochliobolus lunatus were semisynthesized by chlorination, acylation, esterification, and acetalization in one to three steps. The structures of these new derivatives were established by HRESIMS and NMR techniques. All the compounds ( 1 – 71 ) were evaluated for their antialgal and antiplasmodial activities. Among them, 14 compounds displayed antifouling activities against adhesion of the fouling diatoms. In particular, 9 and 34 exhibited strong and selective inhibitory effects against the diatoms Navicula laevissima and Navicula exigua (EC 50 = 6.67 and 8.55 μmol/L), respectively, which were similar in efficacy to those of the positive control SeaNine 211 (EC 50 = 2.90 and 9.74 μmol/L). More importantly, 38 , 39 , and 69 – 71 showed potent antiplasmodial activities against Plasmodium falciparum with IC 50 values ranging from 3.54 to 9.72 μmol/L. Very interestingly, the five antiplasmodial derivatives displayed non-toxicity in the cytotoxicity assays and the zebrafish embryos model, thus, representing potential promising antiplasmodial drug agents. The preliminary structure–activity relationships indicated that biphenyl substituent at C-2, acetonide at positions C-5′ and C-6′, and tri- or tetra-substituted of acyl groups increased the antiplasmodial activity. Therefore, combining evaluation of chemical ecology with pharmacological models will be implemented as a systematic strategy, not only for environmentally friendly antifoulants but also for structurally novel drugs.

First report of a crinivirus infecting mulberry (Morus alba L.) in China - Peng Zhang; Yu Ma; Tao-Tao Han; William Kojo Smith; Jing Yu; Yong-Yuan Cheng; Quan-You Lu (Journal of Plant Pathology, 2022)

Domestication obscures genomic estimates of population history - Chia‐Wei Lu; Cheng‐Te Yao; Chih‐Ming Hung (Molecular Ecology, 2022)
Domesticated species are valuable models to examine phenotypic evolution, and knowledge on domestication history is critical for understanding the trajectories of evolutionary changes. Sequentially Markov Coalescent models are often used to infer domestication history. However, domestication practices may obscure the signal left by population history, affecting demographic inference. Here we assembled the genomes of a recently domesticated species—the society finch—and its parent species—the white‐rumped munia—to examine its domestication history. We applied genomic analyses to two society finch breeds and white‐rumped munias to test whether domestication of the former resulted from inbreeding or hybridization. The society finch showed longer and more runs of homozygosity and lower genomic heterozygosity than the white‐rumped munia, supporting an inbreeding origin in the former. Blocks of white‐rumped munia and other ancestry in society finch genomes showed similar genetic distance between the two taxa, inconsistent with the hybridization origin hypothesis. We then applied two Sequentially Markov Coalescent models— psmc and smc++ —to infer the demographic histories of both. Surprisingly, the two models did not reveal a recent population bottleneck, but instead the psmc model showed a specious, dramatic population increase in the society finch. Subsequently, we used simulated genomes based on an array of demographic scenarios to demonstrate that recent inbreeding, not hybridization, caused the distorted psmc population trajectory. Such analyses could have misled our understanding of the domestication process. Our findings stress caution when interpreting the histories of recently domesticated species inferred by psmc , arguing that these histories require multiple analyses to validate.

Water Temperature at Different Depths Affects the Distribution of Neon Flying Squid (Ommastrephes bartramii) in the Northwest Pacific Ocean - Jintao Wang; Yiqi Cheng; Huajie Lu; Xinjun Chen; Lei Lin; Junbo Zhang (Frontiers in Marine Science, 2022)
Ommastrephes bartramii can vertically swim during its life, and previous studies have suggested the need to account for preferred habitat distribution influenced by water temperatures at different depths. To explore the impacts of deep-water temperature on O. bartramii spatial distribution, we constructed generalized additive models (GAMs) based on the Chinese squid-jigging fishery data and the Argo deep water temperature data during 2005–2018 in the Northwest Pacific Ocean to analyze the relationships between the local abundance of O. bartramii and deep-water temperatures. The results showed that the variables including surface water temperature ( T 0 ), water temperature at 30- and 100-m depths ( T 30 and T 100 ), and water differences between T 0 and T 30 ( D 0–30 ) significantly affected the spatial distribution of O. bartramii . The suitable ranges of each variable are different, > 15.5°C for T 0 , 11–18°C for T 30 , < 6°C for T 100 , and 4–4.5°C for D 0–30 . The areas occupied by the suitable T 30 seemed to reflect the outline of fishing ground, whereas the areas with suitable T 100 were to indicate the high density of O. bartramii . The predicted suitable habitat area and high-density area for O. bartramii are also regulated by El Niño–Southern Oscillation (ENSO) events. We demonstrated how the estimates of O. bartramii spatial distribution would vary influenced by deep-water temperatures in the Northwest Pacific Ocean. This information may help develop an appropriate method for investigating the effects of deep-water temperature on species with vertical migration.

Generation of indole derivatives by an endophytic fungus Chaetomium sp. through feeding 1,2-dimethylindole - Xiaoqi Jin; Haoran Ma; Fuqian Wang; Jie Jiang; Lu Cheng; Song Hu; Geng Zhang (Natural Product Research, 2022)

New monoterpenoids from the stigmas of Crocus sativus - Qing-Wei Fang; Wen-Wei Fu; Jin-Ling Yang; Yue Lu; Jiang-Cheng Chen; Pei-Ying Wu; Xue Zhang; Hong-Xi Xu (Journal of Natural Medicines, 2022)

Impact of diabetes and modifiable risk factors on pancreatic cancer survival in a population-based study after adjusting for clinical factors - Mei-Chin Hsieh; Lu Zhang; Cruz Velasco-Gonzalez; Yong Yi; Lisa A. Pareti; Edward J. Trapido; Vivien W. Chen; Xiao-Cheng Wu (Cancer Causes & Control, 2022)

Adenine base-editing-mediated exon skipping induces gene knockout in cultured pig cells - Xiang-xing Zhu; Jia-sheng Pan; Tao Lin; Ye-cheng Yang; Qiu-yan Huang; Shuai-peng Yang; Zi-xiao Qu; Zi-sheng Lin; Jian-cong Wen; Ai-fen Yan; Juan Feng; Lian Liu; et al. (Biotechnology Letters, 2022)

Diversity of arbuscular mycorrhiza fungi in rhizosphere soil and roots in Vetiveria zizanioides plantation chronosequence in coal gangue heaps - Tianyue Gu; Yuanyuan Mao; Chao Chen; Yong Wang; Qi Lu; Huaqiu Wang; Wei Cheng (Symbiosis, 2022)

A novel alphahypovirus that infects the fungal plant pathogen Sclerotinia sclerotiorum - Weibo Liang; Zhongbo Lu; Jie Duan; Daohong Jiang; Jiatao Xie; Jiasen Cheng; Yanping Fu; Tao Chen; Bo Li; Xiao Yu; Weidong Chen; Yang Lin (Archives of Virology, 2022)

Characterization of a strong constitutive promoter from paper mulberry vein banding virus - William K. Smith; Yu Ma; Jing Yu; Yong-Yuan Cheng; Peng Zhang; Tao-Tao Han; Quan-You Lu (Archives of Virology, 2022)

Optimization of Spray-Drying Process Parameters to Study Anti-Sticking Effect of Hydroxypropyl Methyl Cellulose-VLV on Corni fructus Extracts - Hong Cheng; Chenghao Lu; Gangfeng Xu; Lijie Zhao; Min Lu; Youjie Wang (AAPS PharmSciTech, 2022)

Cytotoxic benzopyranone and xanthone derivatives from a coral symbiotic fungus Cladosporium halotolerans GXIMD 02502 - Chao-Nan Wang; Hu-Mu Lu; Cheng-Hai Gao; Lang Guo; Zhen-Yu Zhan; Jun-Jian Wang; Yong-Hong Liu; Song-Tao Xiang; Jian Wang; Xiao-Wei Luo (Natural Product Research, 2021)

GC–MS fingerprints of essential oils from agarwood grown in wild and artificial environments - Cheng-piao Tian; Xing-dong Yao; Jia-hao Lu; Li-qun Shen; Ai-qun Wu (Trees, 2021)

Comparative Transcriptome Profiling Indicated that Leaf Mesophyll and Leaf Vasculature have Different Drought Response Mechanisms in Cassava - Shujuan Wang; Cheng Lu; Xin Chen; Haiyan Wang; Wenquan Wang (Tropical Plant Biology, 2021)
Drought stress is one of the major environmental factors that limited crop’s growth and production. Cassava known as a tropical crop that is widely distributed in Sub-Saharan Africa. It has a strong drought tolerance and can grow well under tough environmental conditions. Therefore, understanding how cassava responds to drought stress and coordinates survival and accumulation has great theoretical significance for improving crop drought resistance breeding. Many studies on cassava drought responses mainly focused on the leaf and whole seedling. Nevertheless, how the vasculature plays an important role in plant response to water deficiency remains to be fully elucidated. Here, comparative transcriptome analysis was performed on isolated mesophyll tissue and leaf vein vascular tissue of cassava variety KU50 after mild drought treatment to determine the molecular mechanism behind drought resistance in cassava vasculature. Our results showed that KU50 leaves had increased leaf temperature, with characters of rapidly decreased net photosynthetic rate, stomatal conductance, and transpiration rate in leaves, and the intercellular CO 2 concentration accumulated under drought stress. Comparative transcriptome profiling revealed that under drought stress, leaf mesophyll tissue mainly stimulated the biosynthesis of amino acids, glutamic acid metabolism, and starch and sucrose metabolism. In particular, the arginine biosynthesis pathway was significantly enhanced to adapt to the water deficiency in leaf mesophyll tissue. However, in vascular tissue, the response to drought mainly involved ion transmembrane transport, hormone signal transduction, and depolymerization of proteasome. Concretely, ABA signaling and proteasome metabolism, which are involved in ubiquitin regulation, were changed under drought stress in KU50 leaf vascular tissue. Our work highlights that the leaf vasculature and mesophyll in cassava have completely different drought response mechanisms.

Longitudinal virological changes and underlying pathogenesis in hospitalized COVID-19 patients in Guangzhou, China - Zhengtu Li; Yinhu Li; Ruilin Sun; Shaoqiang Li; Lingdan Chen; Yangqing Zhan; Mingzhou Xie; Jiasheng Yang; Yanqun Wang; Airu Zhu; Guoping Gu; Le Yu; et al. (Science China Life Sciences, 2021)

Numerical modeling of the dynamic variation in multiphase CH4 during CO2 enhanced gas recovery from depleted shale reservoirs - Lijun Cheng; Ye Zhang; Jun Liu; Zhaohui Lu; Chunlin Zeng; Peng Zhao (Frontiers of Earth Science, 2021)

Establishment of an immortalized cell line derived from the pupal ovary of Mythimna separata (Lepidoptera: Noctuidae) and identification of the cell source - Yan Tong; Lu-Qiang Cheng; Xuan Li; Xu-Peng Yu; Rui-Hao Shu; Ji-Hong Zhang; Qian Meng; Qi-Lian Qin; Kai Tang; Jian-Xiang Xu; Huan Zhang (Cell and Tissue Research, 2021)

A novel regQTL-SNP and the risk of lung cancer: a multi-dimensional study - Yuhui Yu; Liping Mao; Zhounan Cheng; Xiaoqi Zhu; Jiahua Cui; Xiaoyu Fu; Jingwen Cheng; Yan Zhou; Anni Qiu; Yang Dong; Xun Zhuang; Yihua Lu; et al. (Archives of Toxicology, 2021)

Influence of loading rates under true triaxial stress on the mechanical properties and rockburst characteristics of granite - Zhanjin Li; Lu Zhang; Qun Li; Haojie Cheng (Arabian Journal of Geosciences, 2021)

Ophiuroid fauna of cobalt-rich crust seamounts in the Northwest Pacific Ocean - Wanying Chen; Jieying Na; Chengcheng Shen; Ruiyan Zhang; Bo Lu; Hong Cheng; Chunsheng Wang; Dongsheng Zhang (Acta Oceanologica Sinica, 2021)

A new species of the glass sponge genus Walteria (Hexactinellida: Lyssacinosida: Euplectellidae) from northwestern Pacific seamounts, providing a biogenic microhabitat in the deep sea - Chengcheng Shen; Hong Cheng; Dongsheng Zhang; Bo Lu; Chunsheng Wang (Acta Oceanologica Sinica, 2021)

The chemical profile and biological activity of different extracts of Sapindus mukorossi Gaertn. against Cutibacterium acnes - Min-Ping Wei; Jin-Dan Qiu; Lu Li; Yun-Fei Xie; Ya-Hui Guo; Hang Yu; Yu-Liang Cheng; He Qian; Wei-Rong Yao (Natural Product Research, 2021)

Design, synthesis and insecticidal activity of novel semicarbazones and thiosemicarbazones derived from chalcone - Wei Cheng; Tingting Xiao; Weifeng Qian; Tong Lu; Tingting Zhang; Xiaorong Tang (Natural Product Research, 2021)

Two new nor-sesquiterpenoids from Fusarium tricinctum , an endophytic fungus isolated from Ligusticum chuanxiong - Yu-Mei Cao; Da-Le Guo; Meng-Ying Jin; Lu Tan; Tian-Long Yang; Fang Deng; Yu-Cheng Gu; Xiao-Hua Li; Zhi-Xing Cao; Yun Deng (Natural Product Research, 2021)

A Comparative Analysis of Slack-Based Green Total Factor Productivity in China: a Directional Distance Function - Xuping Zhang; Xiang Chen; Ching-Cheng Lu; Fu-Yueh Cheng (Water, Air, & Soil Pollution, 2021)

RETRACTED ARTICLE: Characterization of Preclinical Pharmacokinetic Properties and Prediction of Human PK Using a Physiologically Based Pharmacokinetic Model for a Novel Anti-Arrhythmic Agent Sulcardine Sulfate - Chang Ren; Yao Wang; Mei Zhang; Dexuan Kong; Chen Ning; Yujie Cheng; Yueying Bian; Mengqi Sun; Shengdi Su; Yucong Wang; Yongjie Zhang; Yang Lu; et al. (Pharmaceutical Research, 2021)

TLR2 Potentiates SR-Marco-Mediated Neuroinflammation by Interacting with the SRCR Domain - Lu Wang; Han-Yu Yang; Cai-Xia Zang; Jun-Mei Shang; Hui Liu; Zi-Hong Zhang; Fang-Yu Yuan; Cheng Ju; Fang-Yuan Li; Xiu-Qi Bao; Dan Zhang (Molecular Neurobiology, 2021)

Response of Escherichia coli to hydrogen nanobubbles: an in vitro evaluation using synchrotron infrared spectroscopy - Jinfang Lu; Jin Zheng; Yadi Wang; Jie Cheng; Xueling Li; Jun Hu; Bin Li; Junhong Lü (Journal of Zhejiang University-SCIENCE B, 2021)

Evaluating the energy, health efficiency, and productivity in OECD - Ching-Cheng Lu; Yung-ho Chiu; Chih-Yu Yang; Tai-Yu Lin (Environmental Geochemistry and Health, 2021)

The effect of the PARK16 rs11240572 variant on brain structure in Parkinson's disease - Lu-yan Gu; Shao-bing Dai; Cheng Zhou; Ting Gao; Jing-jing Wu; Yi Fang; Xiao-jun Guan; Tao Guo; Ran Zheng; Chongyao Jin; Xiao-jun Xu; Zhe Song; et al. (Brain Structure and Function, 2021)

Characteristics of patients discharged and readmitted after COVID-19 hospitalisation within a large integrated health system in the United States - Cheng-Wei Huang; Prashant P. Desai; Kenneth K. Wei; In-Lu Amy Liu; Janet S. Lee; Huong Q. Nguyen (Infectious Diseases, 2021)

Speciation Study on Pb in Different Particle Size Fractions by Sequential Extraction and XAFS Spectroscopy - Yang Shao; Yunan Lu; Min Luo; Ke Yang; Guohua Zhou; Chen Zhao; Hangxin Cheng; Diandou Xu; Lingling Ma (Water, Air, & Soil Pollution, 2021)

An efficient genetic manipulation protocol for dark septate endophyte Falciphora oryzae - Zhen-Zhu Su; Meng-Di Dai; Jia-Nan Zhu; Yu-Lan Zeng; Xuan-Jun Lu; Xiao-Hong Liu; Fu-Cheng Lin (Biotechnology Letters, 2021)

Multivariate machine learning‐based language mapping in glioma patients based on lesion topography - Nan Zhang; Binke Yuan; Jing Yan; Jingliang Cheng; Junfeng Lu; Jinsong Wu (Brain Imaging and Behavior, 2021)

Elastin-like polypeptide and γ-zein fusions significantly increase recombinant protein accumulation in soybean seeds - Jing Yang; HongWei Xun; Lu Niu; Hongli He; Yunqing Cheng; Xiaofang Zhong; Qianqian Zhao; Guojie Xing; Jianfeng Liu; Xiangdong Yang (Transgenic Research, 2021)

Landslides Triggered by the 2020 Qiaojia Mw5.1 Earthquake, Yunnan, China: Distribution, Influence Factors and Tectonic Significance - Xiangli He; Chong Xu; Wenwen Qi; Yuandong Huang; Jia Cheng; Xiwei Xu; Qi Yao; Yongkun Lu; Boyang Dai (Journal of Earth Science, 2021)

Geochemical characteristics of the lower Cambrian Qiongzhusi Formation in Huize area, east Yunnan: implications for paleo-ocean environment and the origin of black rock series - Yong Cheng; Weiqing Liu; Wei Wu; Yu Zhang; Guo Tang; Cong Liu; Qi Nie; Yiming Wen; Ping Lu; Chuanyu Zhang (Arabian Journal of Geosciences, 2021)

Dietary Analysis Based on 18S rDNA, and Stable Carbon and Nitrogen Isotopes in Juvenile Eriocheir sinensis Crabs Reared Under Three Feeding Modes - Zhenzhen Lu; Yunfei Sun; Changlun Xiao; Yongxu Cheng (Frontiers in Marine Science, 2021)
To investigate the growth and feeding conditions of the Chinese mitten crab Eriocheir sinensis under different feeding modes: traditional (mainly consisting of wheat, bran, and soybean meal), formulated, and mixed feeds (1:1 mixture of traditional and formulated feeds) were fed in different crab breeding ponds in this study. During the experiment, the stomach contents of juvenile crabs under the different feeding modes were collected. The main potential eukaryotic food components were studied using 18S ribosomal DNA sequencing, and the contribution of different feeding modes to the feeding source of juvenile crabs were analyzed using C and N stable isotopes. The terminal weight and weight gain rate of crabs under the formulated feeding mode were significantly higher than those in the traditional and mixed feeding modes ( P < 0.05). No differences were observed in the diversity and abundance of the main potential eukaryotic feed components of male and female crabs under different feeding modes ( P > 0.05). Thirty-four phyla, composed mainly of benthic organisms, were identified, with Arthropoda (mainly including Malacostraca, 30.25–51.48%), Phragmoplastophyta (mainly including Embryophyta and Trebouxiophyceae, 5.08–24.74%), and Diatomea (3.13–8.43%) being the most abundant. The δ 13 C and δ 15 N values of the feeding sources and muscle of crabs ranged from −34.45 to −22.21‰, and from 0.27 to 5.66‰, respectively, varying greatly among the three feeding modes and δ 15 N value of muscle under formulated feeding mode was significantly higher than that in traditional feeding mode ( P < 0.05). The proportion of particulate organic matter (11.92–17.50%) is similar to Alternanthera philoxeroides (11.24–16.03%) in three feeding modes. There was no significant difference in feeding habits between male and female crabs under the same and different feeding modes. Juvenile crabs feed on both plant- and animal-based feeds in an aquaculture pond, but they are not complete predators and selectively feed on animal or plant feeds as supplements of that which is deficient, in addition to their main feed.

Inhibition of Candida albicans and induced vaginitis by sapindus water extract - Lu Li; Jindan Qiu; Minping Wei; Yunfei Xie; Hang Yu; Yahui Guo; Yuliang Cheng; Weirong Yao (Natural Product Research, 2021)

Genetic control and phenotypic characterization of panicle architecture and grain yield-related traits in foxtail millet (Setaria italica) - Hui Zhi; Qiang He; Sha Tang; Junjun Yang; Wei Zhang; Huifang Liu; Yanchao Jia; Guanqing Jia; Aiying Zhang; Yuhui Li; Erhu Guo; Ming Gao; et al. (Theoretical and Applied Genetics, 2021)

Transcriptomic analysis provides insights into the AUXIN RESPONSE FACTOR 6-mediated repression of nicotine biosynthesis in tobacco (Nicotiana tabacum L.) - Mengyang Hu; Hongbo Zhang; Bingwu Wang; Zhongbang Song; Yulong Gao; Cheng Yuan; Changjun Huang; Lu Zhao; Yihan Zhang; Longchang Wang; Congming Zou; Xueyi Sui (Plant Molecular Biology, 2021)

Genetic analyses of gynecological disease identify genetic relationships between uterine fibroids and endometrial cancer, and a novel endometrial cancer genetic risk region at the WNT4 1p36.12 locus - Pik Fang Kho; Sally Mortlock; Frederic Amant; Daniela Annibali; Katie Ashton; John Attia; Paul L. Auer; Matthias W. Beckmann; Amanda Black; Louise Brinton; Daniel D. Buchanan; Stephen J. Chanock; et al. (Human Genetics, 2021)

Complex analysis of the personalized pharmacotherapy in the management of COVID-19 patients and suggestions for applications of predictive, preventive, and personalized medicine attitude - Lei-Yun Wang; Jia-Jia Cui; Qian-Ying OuYang; Yan Zhan; Yi-Min Wang; Xiang-Yang Xu; Lu-Lu Yu; Hui Yin; Yang Wang; Chen-Hui Luo; Cheng-Xian Guo; Ji-Ye Yin (EPMA Journal, 2021)
Aims Coronavirus disease 2019 (COVID-19) is rapidly spreading worldwide. Drug therapy is one of the major treatments, but contradictory results of clinical trials have been reported among different individuals. Furthermore, comprehensive analysis of personalized pharmacotherapy is still lacking. In this study, analyses were performed on 47 well-characterized COVID-19 drugs used in the personalized treatment of COVID-19. Methods Clinical trials with published results of drugs use for COVID-19 treatment were collected to evaluate drug efficacy. Drug-to-Drug Interactions (DDIs) were summarized and classified. Functional variations in actionable pharmacogenes were collected and systematically analysed. “Gene Score” and “Drug Score” were defined and calculated to systematically analyse ethnicity-based genetic differences, which are important for the safer use of COVID-19 drugs. Results Our results indicated that four antiviral agents (ritonavir, darunavir, daclatasvir and sofosbuvir) and three immune regulators (budesonide, colchicine and prednisone) as well as heparin and enalapril could generate the highest number of DDIs with common concomitantly utilized drugs. Eight drugs (ritonavir, daclatasvir, sofosbuvir, ribavirin, interferon alpha-2b, chloroquine, hydroxychloroquine (HCQ) and ceftriaxone had actionable pharmacogenomics (PGx) biomarkers among all ethnic groups. Fourteen drugs (ritonavir, daclatasvir, prednisone, dexamethasone, ribavirin, HCQ, ceftriaxone, zinc, interferon beta-1a, remdesivir, levofloxacin, lopinavir, human immunoglobulin G and losartan) showed significantly different pharmacogenomic characteristics in relation to the ethnic origin of the patient. Conclusion We recommend that particularly for patients with comorbidities to avoid serious DDIs, the predictive, preventive, and personalized medicine (PPPM, 3 PM) strategies have to be applied for COVID-19 treatment, and genetic tests should be performed for drugs with actionable pharmacogenes, especially in some ethnic groups with a higher frequency of functional variations, as our analysis showed. We also suggest that drugs associated with higher ethnic genetic differences should be given priority in future pharmacogenetic studies for COVID-19 management. To facilitate translation of our results into clinical practice, an approach conform with PPPM/3 PM principles was suggested. In summary, the proposed PPPM/3 PM attitude should be obligatory considered for the overall COVID-19 management.

Proteomics provides individualized options of precision medicine for patients with gastric cancer - Wenwen Huang; Dongdong Zhan; Yazhuo Li; Nairen Zheng; Xin Wei; Bin Bai; Kecheng Zhang; Mingwei Liu; Xuefei Zhao; Xiaotian Ni; Xia Xia; Jinwen Shi; et al. (Science China Life Sciences, 2021)

Talaromyces Marneffei Infection in an HIV-Negative Child with a CARD9 Mutation in China: A Case Report and Review of the Literature - Cheng-yan You; Fang Hu; Si-wei Lu; Dan-dan Pi; Feng Xu; Cheng-jun Liu; Yue-qiang Fu (Mycopathologia, 2021)

An in-depth analysis reveals two new genetic variants on 22q11.2 associated with vitiligo in the Chinese Han population - Xianfa Tang; Hui Cheng; Lu Cheng; Bo Liang; Mengyun Chen; Xiaodong Zheng; Fengli Xiao (Molecular Biology Reports, 2021)

The trophocytes and oenocytes of worker and queen honey bees (Apis mellifera) exhibit distinct age-associated transcriptome profiles - Cheng-Yen Lu; Yu-Ting Weng; Bertrand Tan; Chin-Yuan Hsu (GeroScience, 2021)

Design and synthesis of sinomenine isoxazole derivatives via 1,3-dipolar cycloaddition reaction - Hongmei Pan; Tong Lu; Xuedan Wu; Chengwen Gu; Naili Tao; Biao Zhang; Ao Wang; Guangmei Chen; Kehua Zhang; Jie Cheng; Jie Jin (Natural Product Research, 2021)

A new diketopiperazine from an endophytic fungus Aspergillus aculeatus F027 - Haoran Ma; Fuqian Wang; Xiaoqi Jin; Jie Jiang; Song Hu; Lu Cheng; Geng Zhang (Natural Product Research, 2021)

Natural constituents from food sources as therapeutic agents for obesity and metabolic diseases targeting adipose tissue inflammation - Dan Li; Tian Zhang; Jinjian Lu; Cheng Peng; Ligen Lin (Critical Reviews in Food Science and Nutrition, 2021)

Quantifying nitrate pollution sources of the drinking water source area using a Bayesian isotope mixing model in the northeastern suburbs of Beijing, China - Liangsuo Ren; Lirong Cheng; Shurong Zhang; Aizhong Ding; Yi Zhu; Chunlei Lu; Yu Li; Qing Yang; Jie Li (Isotopes in Environmental and Health Studies, 2021)

World Octopus Fisheries - Warwick H. H. Sauer; Ian G. Gleadall; Nicola Downey-Breedt; Zöe Doubleday; Graham Gillespie; Manuel Haimovici; Christian M. Ibáñez; Oleg N. Katugin; Stephen Leporati; Marek R. Lipinski; Unai Markaida; Jorge E. Ramos; et al. (Reviews in Fisheries Science & Aquaculture, 2021)

Sorghum breeding in the genomic era: opportunities and challenges - Huaiqing Hao; Zhigang Li; Chuanyuan Leng; Cheng Lu; Hong Luo; Yuanming Liu; Xiaoyuan Wu; Zhiquan Liu; Li Shang; Hai-Chun Jing (Theoretical and Applied Genetics, 2021)

Foetidibacter luteolus gen. nov., sp. nov., isolated from the rhizosphere of Salvia miltiorrhiza - Qian Pu; Guo-hong Zeng; Gui-wei Wang; Ling-er Lu; Ang Li; Xu-rui Cheng; Xue-ying Wang; Ou Li; Cong Sun; Xiu-fang Hu (Archives of Microbiology, 2021)

Detection of Vestibular Schwannoma on Triple-parametric Magnetic Resonance Images Using Convolutional Neural Networks - Tzu-Hsuan Huang; Wei-Kai Lee; Chih-Chun Wu; Cheng-Chia Lee; Chia-Feng Lu; Huai-Che Yang; Chun-Yi Lin; Wen-Yuh Chung; Po-Shan Wang; Yen-Ling Chen; Hsiu-Mei Wu; Wan-You Guo; et al. (Journal of Medical and Biological Engineering, 2021)
Purpose The first step in typical treatment of vestibular schwannoma (VS) is to localize the tumor region, which is time-consuming and subjective because it relies on repeatedly reviewing different parametric magnetic resonance (MR) images. A reliable, automatic VS detection method can streamline the process. Methods A convolutional neural network architecture, namely YOLO-v2 with a residual network as a backbone, was used to detect VS tumors from MR images. To heighten performance, T1-weighted–contrast-enhanced, T2-weighted, and T1-weighted images were combined into triple-channel images for feature learning. The triple-channel images were cropped into three sizes to serve as input images of YOLO-v2. The VS detection effectiveness levels were evaluated for two backbone residual networks that downsampled the inputs by 16 and 32. Results The results demonstrated the VS detection capability of YOLO-v2 with a residual network as a backbone model. The average precision was 0.7953 for a model with 416 × 416-pixel input images and 16 instances of downsampling, when both the thresholds of confidence score and intersection-over-union were set to 0.5. In addition, under an appropriate threshold of confidence score, a high average precision, namely 0.8171, was attained by using a model with 448 × 448-pixel input images and 16 instances of downsampling. Conclusion We demonstrated successful VS tumor detection by using a YOLO-v2 with a residual network as a backbone model on resized triple-parametric MR images. The results indicated the influence of image size, downsampling strategy, and confidence score threshold on VS tumor detection.

In vitro regeneration and clonal fidelity assessment on induction and differentiation of protocorm-like body from Pleione bulbocodioides (Franch.) - Fangmei Zhou; Weipeng Huang; Wen Cheng; Jingjing Lu; Bingqi Zhu; Jie Yu; Zhishan Ding; Qianxing Jin (Plant Cell, Tissue and Organ Culture (PCTOC), 2021)

Identification of differentially expressed genes associated with aluminum resistance in the soybean plant - Jing-xuan Wang; Bo Wang; Lu-bin Cui; Hao Xie; Run-zhi Li; Cheng Wang; Zhang-jie Nan; Yu-shu Liu; Jing-yu Ma; Yun-jin Sun; Wei-yu Li (Physiology and Molecular Biology of Plants, 2021)

Enhancement of IUdR Radiosensitization in Cancer Therapy by Low-Energy Transmission X Ray Irradiation - Chien-Chih Ke; Jia-Je Li; Hsueh-Peng Wu; Wen-Wang Kuo; Yi-An Chen; Cheng-Hsiu Lu; Hsin-Ell Wang; Shih-Ming Hsu; Ya-Ju Hsieh; Ren-Shyan Liu (Journal of Medical and Biological Engineering, 2021)

Helios serves as a suppression marker to reduce regulatory T cell function in pancreatic cancer patients - Min-Feng Liu; Cheng Jin; Tao Wu; En-Hong Chen; Minxue Lu; Huan-Long Qin (Immunologic Research, 2021)

Molecular characterization of a novel single-stranded RNA virus, ChRV1, isolated from the plant-pathogenic fungus Colletotrichum higginsianum - Hong Liu; Hui Wang; Xun Lu; Cheng Xiao; Bo Peng; Qian Zhou (Archives of Virology, 2021)

Ring distribution patterns—diversification or speciation? Comparative phylogeography of two small mammals in the mountains surrounding the Sichuan Basin - Yanqun Wang; Anderson Feijó; Jilong Cheng; Lin Xia; Zhixin Wen; Deyan Ge; Jian Sun; Liang Lu; Song Li; Qisen Yang (Molecular Ecology, 2021)
Studying the genetic differentiation in a unique geographical area contributes to understanding the process of speciation. Here, we explore the spatial genetic structure and underlying formation mechanism of two congeneric small mammal species ( Apodemus draco and A. chevrieri ), which are mainly distributed in the mountains surrounding the lowland Sichuan Basin, southwest China. We applied a set of comparative phylogeographical analyses to determine their genetic diversification patterns, combining mitochondrial ( Cytb and COI ) and nuclear (microsatellite loci) markers, with dense sampling throughout the range (411 A . draco from 21 sites and 191 A . chevrieri from 22 sites). Moreover, we performed three complementary statistical methods to investigate the correlation between genotype and geographical and environmental components, and predicted the potential suitable distributional range under the present and historical climate conditions. Our results suggest that both species have experienced allopatric differentiation and admixture in historical periods, resulting in a ring‐shape diversification, under the barrier effect of the Sichuan Basin. We infer that the tectonic events of the Qinghai–Tibetan Plateau and climatic oscillations during the Quaternary played an important role on the genetic divergence of the two species by providing environmental heterogeneity and geographical variation. Our study reveals a case of two sympatric small mammals following a ring‐shaped diversification pattern and provides insight into the process of differentiation.

Influence of Maillard Reaction in Volatile Flavor Compounds of Blue Round Scad ( Decapterus maruadsi ) Enzymatic Hydrolysate - Rongbin Zhong; Xiaodan Lu; Ji Zhong; Lijiao Chen; Wenjian Cheng; Peng Liang (Journal of Aquatic Food Product Technology, 2021)

PtP38 May Increase the Immune Ability of Portunus trituberculatus Stimulated by LPS Imitating a Gram-Negative Bacterial Infection - Cheng-Peng Lu; Chao-Guang Wei; Jun-Quan Zhu; Dao-Jun Tang; Chun-Lin Wang; Cong-Cong Hou (Frontiers in Marine Science, 2021)
The P38 mitogen-activated protein kinase (MAPK) signal transduction pathway is widespread in organisms and plays important roles in immune activities. The infection mechanism of environmental gram-negative bacteria on crustaceans is an important scientific problem. In this study, the cDNA full-length sequence of Portunus trituberculatus P38 (PtP38) was cloned and its structure was analyzed by bioinformatics methods. To study the function of the PtP38 gene after a Gram-negative bacterial infection, we injected P. trituberculatus with LPS to activate the immune response instead of directly infecting with Gram-negative bacteria. With LPS stimulation, the expression of the PtP38 gene in different tissues increased significantly. At the same time, the expression of immune-related genes (ALF and crustin) in the hepatopancreas, activities of antioxidant enzymes [superoxide dismutase (SOD), catalase (CAT), and inducible nitric oxide synthase (iNOS) enzymes], and expression of apoptosis-related genes (caspase2 and caspase3) were increased significantly. To further conform the function of PtP38 in the immune response, we injected P. trituberculatus with P38 inhibitor and subsequently injected with LPS. The results showed that the expression of immune-related genes was inhibited, the activity of antioxidant enzymes was decreased, and the expression of apoptosis-related genes were inhibited. Thus, we speculated that PtP38 may increase the immune ability by improving the expression of antimicrobial peptides, increasing the activity of oxidative stress-related enzymes, and promoting cell apoptosis in infected P. trituberculatus . This study also laid the foundation for further study of the P38 MAPK signaling pathway and immune mechanism of P. trituberculatus .

Impact factors of the accumulation, migration and spread of antibiotic resistance in the environment - Zibo Lin; Tao Yuan; Lai Zhou; Sen Cheng; Xu Qu; Ping Lu; Qiyan Feng (Environmental Geochemistry and Health, 2021)

Nonstructural protein NS26 of grass carp reovirus is a principal regulator for viral replication and infection - Jian‐Fei Lu; Sheng Luo; Tian‐Cheng Jin; Xin‐Jiang Lu; Jiong Chen (Journal of Fish Diseases, 2021)

Dexamethasone Protects Against Ischaemic Brain Injury via Inhibiting the pAkt Signalling Pathway Through Increasing Hap1 - Ning Xin; Jun Lu; Yanlong Zhou; Yanbo Cheng (Neurotoxicity Research, 2021)

Drivers of phenology shifts and their effect on productivity in northern grassland of China during 1984–2017—evidence from long-term observational data - Lingling Xu; Xianzhou Zhang; Yongli Wang; Yang Fu; Hao Yan; Shuan Qian; Lu Cheng (International Journal of Biometeorology, 2021)

Investigation on the dust migration behavior and safety zone in the fully mechanized mining face - Xin-xiao Lu; Cheng-yan Wang; Yun Xing; Cong Shen; Guo-yu Shi (Environmental Science and Pollution Research, 2021)

Altered white matter structural networks in drug-naïve patients with obsessive-compulsive disorder - Cong Zhou; Liangliang Ping; Wei Chen; Mengxin He; Jian Xu; Zonglin Shen; Yi Lu; Binli Shang; Xiufeng Xu; Yuqi Cheng (Brain Imaging and Behavior, 2021)

The molecular mechanism of a novel derivative of BTO-956 induced apoptosis in human myelomonocytic lymphoma cells - Yu-Lin Li; De-Jun Zhou; Zheng-Guo Cui; Lu Sun; Qian-Wen Feng; Shahbaz Ahmad Zakki; Yusuke Hiraku; Cheng-Ai Wu; Hidekuni Inadera (Apoptosis, 2021)

Analytical Stress Solutions for a Deep Buried Circular Tunnel Under an Unsteady Temperature Field - Qian-xiang Cheng; Ai-zhong Lu; Chong-lin Yin (Rock Mechanics and Rock Engineering, 2021)

Long Non-coding RNA MALAT1 Upregulates ZEB2 Expression to Promote Malignant Progression of Glioma by Attenuating miR-124 - Hongyu Cheng; Haikang Zhao; Xin Xiao; Qian Huang; Wen Zeng; Bo Tian; Tao Ma; Dan Lu; Yulong Jin; Yuqian Li (Molecular Neurobiology, 2021)

Groundwater sources, flow patterns, and hydrochemistry of the Central Yinchuan Plain, China - Ying Li; Ping Wu; Xiao-Qin Huang; Bo Zhang; Zhao-Xiang Xu; Yang Li; Jie Li; Lu-Chen Wang; Yu-Fang Sun; Xu-Chen Meng; Cheng-Wen Wang; Zi-Zhao Cai (Hydrogeology Journal, 2021)

Improvement and application of preprocessing technique for multitrace seismic impedance inversion - Zhong Fei-Yan; Zhou Lu; Dai Rong-Huo; Yin Cheng; Zhao Hu; Xu Liang-Jun (Applied Geophysics, 2021)

Ecological engineering in pond aquaculture: a review from the whole‐process perspective in China - XingGuo Liu; Zhengyi Shao; Guofeng Cheng; Shimin Lu; Zhaojun Gu; Hao Zhu; Hongye Shen; Jie Wang; Xiaolong Chen (Reviews in Aquaculture, 2021)
Pond aquaculture undeniably offers the potential for food production worldwide. In China, 45.83% of aquatic production is currently from pond aquaculture. However, with the continuous expansion of this practice, environmental problems such as a high level of water consumption, aquaculture water deterioration, pollution from effluent and aquatic product quality decline seriously restrict the sustainable development of pond aquaculture. In this review, we summarise the (i) the impacts of pond aquaculture on the environment, (ii) research progress in pond aquaculture ecological engineering, (iii) existing technologies regarding pond aquaculture ecological engineering systems, (iv) effects of applying pond aquaculture ecological engineering and (v) summary and prospects. Moreover, we discuss the merits and drawbacks of each method and technology, and future research priorities are reviewed. With this, an understanding of the role played by ecological engineering in pond aquaculture is provided, as well as guidance for precisely managing aquaculture water and effluent, aquaculture practices, and technological developments. In summary, the pond aquaculture ecological engineering can be managed so as to improve animal welfare and the stability of water treatment systems, reducing the adverse effects on the environment and public health, and enabling the sustainable development of pond aquaculture.

Distribution and Assessment of Cr, Pb, Ni and Cd in Topsoil of the Modern Yellow River Delta, China - Hongjun Yang; Jingkuan Sun; Jiangbao Xia; Zhanyong Fu; Shuai Cheng; Tian Li; Pengshuai Shao; Kaikai Dong; Jinzhao Ma; Lu Feng (Wetlands, 2021)

Estimation of rice plant potassium accumulation based on non-negative matrix factorization using hyperspectral reflectance - Jingshan Lu; Wanyu Li; Minglei Yu; Xiangbin Zhang; Yong Ma; Xi Su; Xia Yao; Tao Cheng; Yan Zhu; Weixing Cao; Yongchao Tian (Precision Agriculture, 2021)

Heat-Killed Lactobacillus reuteri GMNL-263 Inhibits Systemic Lupus Erythematosus–Induced Cardiomyopathy in NZB/W F1 Mice - Yu-Lan Yeh; Min-Chi Lu; Bruce Chi-Kang Tsai; Bor-Show Tzang; Shiu-Min Cheng; Xiaoyong Zhang; Liang-Yo Yang; B. Mahalakshmi; Wei-Wen Kuo; Peng Xiang; Chih-Yang Huang (Probiotics and Antimicrobial Proteins, 2021)

Decomposition time, chemical traits and climatic factors determine litter-mixing effects on decomposition in an alpine steppe ecosystem in Northern Tibet - Youchao Chen; Shuqin Ma; Hongmao Jiang; Degyi Yangzom; Genwei Cheng; Xuyang Lu (Plant and Soil, 2021)

Reliability and Validity of a Mobile Device for Assessing Head Control Ability - Mohammad Nikkhoo; Chi-Chien Niu; Chen-Ju Fu; Meng-Ling Lu; Wen-Chien Chen; Yang-Hua Lin; Chih-Hsiu Cheng (Journal of Medical and Biological Engineering, 2021)

Dispersion of carbon dioxide released from buried high-pressure pipeline over complex terrain - Huiru Wang; Bin Liu; Xiong Liu; Cheng Lu; Jiajia Deng; Zhanping You (Environmental Science and Pollution Research, 2021)

Starch bio-template synthesis of W-doped CeO2 catalyst for selective catalytic reduction of NOx with NH3: influence of ignition temperature - Zhi-Bo Xiong; Zhen-Zhuang Li; Yan-Ping Du; Cheng-Xu Li; Wei Lu; Su-Le Tian (Environmental Science and Pollution Research, 2021)

Occurrence of dioxin-like POPs in soils from urban green space in a metropolis, North China: implication to human exposure - Qingqi Die; Anxiang Lu; Cheng Li; Haifeng Li; Hongling Kong; Bingru Li (Environmental Science and Pollution Research, 2021)

RNA m6A methylation promotes the formation of vasculogenic mimicry in hepatocellular carcinoma via Hippo pathway - Kailiang Qiao; Yantao Liu; Zheng Xu; Haohao Zhang; Heng Zhang; Chao Zhang; Zhi Chang; Xinyan Lu; Zhongwei Li; Ce Luo; Yanrong Liu; Cheng Yang; et al. (Angiogenesis, 2021)

Two new physalin derivatives from Physalis alkekengi L. var. franchetii (Mast.) Makino - Jian-Lu Sun; Yong-Jun Jiang; Lin Cheng (Natural Product Research, 2021)

Comparison of the Nutritional Quality of Three Edible Tissues from Precocious and Normal Adult Female Chinese Mitten Crabs ( Eriocheir sinensis ) - Huafeng Cheng; Haoran Wu; Feng Liang; Mengtian Ge; Shaotong Jiang; Lin Lin; Jianfeng Lu (Journal of Aquatic Food Product Technology, 2021)

A CCR4-associated factor 1, OsCAF1B, confers tolerance of low-temperature stress to rice seedlings - Jhen-Cheng Fang; Yin-Chuan Tsai; Wei-Lun Chou; Hsin-Yi Liu; Chun-Chen Chang; Shaw-Jye Wu; Chung-An Lu (Plant Molecular Biology, 2021)

Screening and identification of a specific peptide binding to breast cancer cells from a phage-displayed peptide library - Huijuan Jin; Xiaojie Gao; Li Xiao; Huimin He; Sinan Cheng; Caixia Zhang; Yifan Hou; Fengying Song; Xiaorong Su; Qian Gao; Zheng Lu; Ruina Yang; et al. (Biotechnology Letters, 2021)

CD40 induces an antimicrobial response against the intracellular pathogen Streptococcus agalactiae in Nile tilapia, Oreochromis niloticus - Hongli Xia; Huimin Fan; Meng Long; Jun Cheng; Wenjie Chen; Dapeng Yu; Liqun Xia; Yishan Lu (Journal of Fish Diseases, 2021)
Streptococcus agalactiae is a Gram‐positive facultative intracellular bacterium that leads to severe economic loss of tilapia worldwide. Previous studies demonstrated that CD40 contributes to host protection against intracellular injection. In this study, CD40 was characterized from Nile tilapia ( Oreochromis niloticus ), named OnCD40. Sequence analysis showed that open reading frame of OnCD40 was 933 bp, containing a single peptide, a transmembrane domain and four cysteine‐rich domains. The qRT‐PCR revealed that OnCD40 was expressed in all examined tissues with the most abundant ones in spleen and thymus. After S. agalactiae stimulation, the expression of OnCD40 was significantly induced in most of the detected organs. Moreover, OnCD40‐overexpressing fish elicited significant protection against subsequent S. agalactiae challenge; approximately 10000‐fold fewer bacteria were detected in spleen of OnCD40‐overexpressing fish in comparison with control fish. Thus, CD40 had protecting function in Nile tilapia against intracellular pathogens.

Two new lignans from Zanthoxylum armatum - Yan Sun; Qing-Hong Zeng; Hui-Qiang Lu; Fan-Cheng Meng; Yong Shen; Wei-You Zeng; Hao Chi; Yu-Qiang Zhou; Min Chen (Natural Product Research, 2020)

Concurrent increases in post-pacing action potential duration and contractility predict occurrence of ventricular arrhythmia - Chih-Min Liu; Feng-Zhi Lin; Yao-Chang Chen; Yung-Kuo Lin; Yen-Yu Lu; Cheng-I Wu; Satoshi Higa; Shih-Ann Chen; Yi-Jen Chen (Pflügers Archiv - European Journal of Physiology, 2020)

LincRNA-Cox2 promotes pulmonary arterial hypertension by regulating the let-7a-mediated STAT3 signaling pathway - Gesheng Cheng; Lu He; Yushun Zhang (Molecular and Cellular Biochemistry, 2020)

Assessing SARS-CoV-2 RNA levels and lymphocyte/T cell counts in COVID-19 patients revealed initial immune status as a major determinant of disease severity - Mingfeng Han; Mengyuan Xu; Yafei Zhang; Zhongping Liu; Shasha Li; Tengfei He; Jinsong Li; Yong Gao; Wanjun Liu; Tuantuan Li; Zixiang Chen; Xin Huang; et al. (Medical Microbiology and Immunology, 2020)

RamA, a transcriptional regulator conferring florfenicol resistance in Leclercia adecarboxylata R25 - Cong Cheng; Yuanyuan Ying; Danying Zhou; Licheng Zhu; Junwan Lu; Aifang Li; Qiyu Bao; Mei Zhu (Folia Microbiologica, 2020)
Due to the inappropriate use of florfenicol in agricultural practice, florfenicol resistance has become increasingly serious. In this work, we studied the novel florfenicol resistance mechanism of an animal-derived Leclercia adecarboxylata strain R25 with high-level florfenicol resistance. A random genomic DNA library was constructed to screen the novel florfenicol resistance gene. Gene cloning, gene knockout, and complementation combined with the minimum inhibitory concentration (MIC) detection were conducted to determine the function of the resistance-related gene. Sequencing and bioinformatics methods were applied to analyze the structure of the resistance gene-related sequences. Finally, we obtained a regulatory gene of an RND (resistance-nodulation-cell division) system, ramA , that confers resistance to florfenicol and other antibiotics. The ramA -deleted variant (LA-R25Δ ramA ) decreased the level of resistance against florfenicol and several other antibiotics, while a ramA -complemented strain (pUCP24-prom- ramA/ LA-R25Δ ramA ) restored the drug resistance. The whole-genome sequencing revealed that there were five RND efflux pump genes ( mdtABC , acrAB , acrD , acrEF , and acrAB -like) encoded over the chromosome, and ramA located upstream of the acrAB -like genes. The results of this work suggest that ramA confers resistance to florfenicol and other structurally unrelated antibiotics, presumably by regulating the RND efflux pump genes in L. adecarboxylata R25.

The interplay among ecological footprint, real income, energy consumption, and trade openness in 13 Asian countries - Wen-Cheng Lu (Environmental Science and Pollution Research, 2020)

The Bre1/Rad6 machinery: writing the central histone ubiquitin mark on H2B and beyond - Zhi-Heng Deng; Hua-Song Ai; Cheng-Piao Lu; Jia-Bin Li (Chromosome Research, 2020)

Sphingosylphosphorylcholine alleviates hypoxia-caused apoptosis in cardiac myofibroblasts via CaM/p38/STAT3 pathway - Ying Li; Qi Qi; Wan-cheng Yang; Tian-liang Zhang; Chen-chen Lu; Yu-juan Yao; Wei-hua Kong; Jing Zhao (Apoptosis, 2020)

Anxiety is associated with increased risk for atrial cardiopathy - Zhaolu Wang; Huiyuan Qin; Guilin Chen; Yan Dai; Yingyuan Cai; Xi Cheng; Yun Qian; Ming Chu; Xiaowei Lu (Acta Neurologica Belgica, 2020)

Analysis of genetic architecture and favorable allele usage of agronomic traits in a large collection of Chinese rice accessions - Xiuxiu Li; Zhuo Chen; Guomin Zhang; Hongwei Lu; Peng Qin; Ming Qi; Ying Yu; Bingke Jiao; Xianfeng Zhao; Qiang Gao; Hao Wang; Yunyu Wu; et al. (Science China Life Sciences, 2020)

Combined effects of di (2-ethylhexyl) phthalate and bisphenol A on thyroid hormone homeostasis in adolescent female rats - Xuan Zhang; Yuejiao Zhao; Cheng Cheng; Liuli Li; Mingyang Xiao; Guopei Zhang; Xiaobo Lu (Environmental Science and Pollution Research, 2020)

Content and health risk assessment of heavy metals and polybrominated diphenyl ethers in fish from Songhua Lake (Jilin City), China - Mengnan Shen; Chunyu Kang; Tiehong Song; Hai Lu; Yuehong Wang; Bowen Yu; Ru Wang; Jie Cheng (Environmental Science and Pollution Research, 2020)

A Comparative Study of Associated Microbiota Between Pig Farm and Pig Slaughterhouse in Guangdong, China - Jian-Yong Wu; Yan-Shan Zhu; Cheng Guo; Yao Xia; Zhong-Min Guo; Qian-Lin Li; Jia-Hai Lu (Current Microbiology, 2020)

Functional Analysis of a Fibronectin Binding Protein of Streptococcus parasanguinis FW213 - Yi-Ywan M. Chen; Pei-Shan Lu; Pei-Hua Tsai; Cheng-Hsun Chiu (Current Microbiology, 2020)

Characterization of a Protease Hyper-Productive Mutant of Bacillus pumilus by Comparative Genomic and Transcriptomic Analysis - Yong-Cheng Liu; Lin-Li Han; Tian-Yu Chen; Yan-Bing Lu; Hong Feng (Current Microbiology, 2020)

A novel system to rapidly detect protein–protein interactions (PPIs) based on fluorescence co-localization - Nan Hu; Zhan-Qi Dong; Ting-Ting Chen; Ning Zheng; Qin Wu; Peng Chen; Cheng Lu; Min-Hui Pan (Biotechnology Letters, 2020)

Antibacterial effect of Blumea balsamifera DC. essential oil against Haemophilus parasuis - Changliang He; Peiyi Yang; Lu Wang; Xiaolin Jiang; Wei Zhang; Xiaoxia Liang; Lizi Yin; Zhongqiong Yin; Yi Geng; Zhijun Zhong; Xu Song; Yuanfeng Zou; et al. (Archives of Microbiology, 2020)

Retraction Note to: miR-376a inhibits the proliferation and invasion of osteosarcoma by targeting FBXO11 - Qiaolong Xu; Li Cheng; Jianyang Chen; Wenjie Lu; Peinian Wang (Human Cell, 2020)

Modification-bioremediation of copper, lead, and cadmium-contaminated soil by combined ryegrass (Lolium multiflorum Lam.) and Pseudomonas aeruginosa treatment - Guang-yu Shi; Ying-jia Yan; Zhi-qiang Yu; Lu Zhang; Yuan-yuan Cheng; Wei-lin Shi (Environmental Science and Pollution Research, 2020)

Molecular Functional Characterisation of MechlPPDK Promoter in Transgenic Tobacco - Haiyan Wang; Xu Shen; Cheng Lu; Kaimian Li; Wenquan Wang (Tropical Plant Biology, 2020)

Comparing GWAS and Brain Structure-Specific Gene Expression Profiles Identifies Psychiatric Disorder-Related Brain Structures at Different Developmental Stages - Xin Qi; Cuiyan Wu; Yanan Du; Shiqiang Cheng; Yan Wen; Mei Ma; Chujun Liang; Li Liu; Bolun Cheng; Lu Zhang; Ping Li; Feng Zhang (Neuroscience Bulletin, 2020)

Influence of photoinhibition on nitrification by ammonia-oxidizing microorganisms in aquatic ecosystems - Shimin Lu; Xingguo Liu; Chong Liu; Guofeng Cheng; Hongye Shen (Reviews in Environmental Science and Bio/Technology, 2020)

Evolution of Neolithic site distribution (9.0–4.0 ka BP) in Anhui, East China - Li Wu; Xiaoling Sun; Wei Sun; Cheng Zhu; Tongxin Zhu; Shuguang Lu; Hui Zhou; Qingchun Guo; Houchun Guan; Wei Xie; Rui Ke; Guiping Lin (Journal of Geographical Sciences, 2020)

Five new ent -kaurane diterpenes from Annona squamosa L. pericarps - Ya-Yun Chen; Cheng-Yao Ma; Mao-Lin Wang; Jia-Hui Lu; Peng Hu; Jian-Wei Chen; Xiang Li; Yong Chen (Natural Product Research, 2020)

Blockade of HCN2 Channels Provides Neuroprotection Against Ischemic Injury via Accelerating Autophagic Degradation in Hippocampal Neurons - Cheng Chen; Li Liu; Ya-Qiao Shu; Ping Jing; Yun Lu; Xiao-Xue Zhang; Xian-Gang Zong; Lian-Jun Guo; Chang-Jun Li (Neuroscience Bulletin, 2020)

A Near Infrared Spectroscopy System for Assessing Rehabilitation on Peripheral Arterial Occlusion Patients - Shao-Hung Lu; Cheng-Lun Tsai; Tieh-Cheng Fu; Po-Hung Chang; Shao-Ming Lu (Journal of Medical and Biological Engineering, 2020)
Purpose A near-infrared spectroscopy system was developed to evaluate peripheral arterial occlusive disease (PAOD). The wireless device can take measurements when patients are doing rehabilitation exercise. Methods Two LED modules with wavelengths of 740 nm, 808 nm and 850 nm were placed over 32 mm away from the photodiode to detect the deep backscattering from muscle tissue. The absorbance difference from the extent of tissue oxygenation was extracted using a modified Beer’s law. Measurements taken on different muscle groups were applied to determine which branch of artery is occluded. Results The changes in oxygenation of gastrocnemius and tibialis anterior muscle were recorded when PAOD patients were riding a stationary bicycle. The drop in oxygenation with exercise generally should recover within 15 min of continuing exercise. Otherwise, the artery is not capable to provide enough blood supply to the exercising muscles. Since gastrocnemius is the primary muscle used in biking exercise, the compensatory vasodilation in gastrocnemius leads to hypoperfusion in tibialis anterior muscle. Conclusion This NIRS system is helpful for detecting the changes in tissue oxygenation during exercise. Muscle hypoxia was more obvious during exercise when the artery had some degree of occlusion.

Review: recent developments of substrates for nitrogen and phosphorus removal in CWs treating municipal wastewater - Shuting Shen; Xiang Li; Fangkui Cheng; Xiao Zha; Xiwu Lu (Environmental Science and Pollution Research, 2020)

Bacomics: a comprehensive cross area originating in the studies of various brain–apparatus conversations - Dezhong Yao; Yangsong Zhang; Tiejun Liu; Peng Xu; Diankun Gong; Jing Lu; Yang Xia; Cheng Luo; Daqing Guo; Li Dong; Yongxiu Lai; Ke Chen; et al. (Cognitive Neurodynamics, 2020)

Reconnaissance and learning after the February 6, 2018, earthquake in Hualien, Taiwan - Jui-Liang Lin; Chun-Hsiang Kuo; Yu-Wen Chang; Shu-Hsien Chao; Yi-An Li; Wen-Cheng Shen; Chung-Han Yu; Cho-Yen Yang; Fan-Ru Lin; Hsiao-Hui Hung; Chun-Chung Chen; Chin-Kuo Su; et al. (Bulletin of Earthquake Engineering, 2020)

A new metagenome binning method based on gene uniqueness - Yulin Kang; Cheng Wan; Sifen Lu; Zhehan Fu; Antony K. Chen; Zuhong Lu (Genes & Genomics, 2020)

Molecular phylogeny and morphology reveal two new species of Coltricia (Hymenochaetaceae Basidiomycota) from China - Lu-Sen Bian; Yu-Cheng Dai (Mycological Progress, 2020)

A comparative study of UV/H2O2 and UV/PDS for the degradation of micro-pollutants: kinetics and effect of water matrix - Jing Gao; Congwei Luo; Lu Gan; Daoji Wu; Fengxun Tan; Xiaoxiang Cheng; Weiwei Zhou; Shishun Wang; Fumiao Zhang; Jun Ma (Environmental Science and Pollution Research, 2020)

Toxicity assessment of electrochemical advanced oxidation process-treated groundwater from a gas station with petrochemical contamination - How-Ran Chao; Danielle E. Que; Alisha C. Aquino; Yan-You Gou; Lemmuel L. Tayo; Yi-Hsien Lin; Ming-Hsien Tsai; Fu-Lin Hsu; I-Cheng Lu; Sheng-Lun Lin; Natwat Srikhao; Cherng-Gueih Shy; et al. (Environmental Monitoring and Assessment, 2020)

Beach ridges of Dali Lake in Inner Mongolia reveal precipitation variation during the Holocene - Mengyao Jiang; Zhiyong Han; Xusheng Li; Yong Wang; Thomas Stevens; Jun Cheng; Cunjuan Lv; Yuwen Zhou; Qianqian Yang; Zhiwei Xu; Shuangwen Yi; Huayu Lu (Journal of Quaternary Science, 2020)
Variability in East Asian summer monsoon precipitation during the Holocene remains of debate. In this study, we use a closed lake with well‐dated lake beach ridges located on the margin of the East Asian summer monsoon, a region highly sensitive to monsoon precipitation changes, to obtain a temporal sequence of water volume in North China. The elevation of each beach ridge calibrated to the modern lake level was surveyed. Optically stimulated luminescence dating of undisturbed sediments of beach ridges was performed. The lake area and water volume corresponding to each beach ridge were calculated using a digital elevation model. This study reveals relatively reduced monsoon precipitation from ~12 to 7 ka interrupted by strengthening of the monsoon circulation to a maximum from ~7 to ~5 ka and followed by greatly reduced monsoon intensity until the present day. These results demonstrate that changes in the East Asian summer monsoon precipitation may not be directly driven by global temperature or atmospheric CO 2 content. Rather, we suggest that variation in the the monsoon margin precipitation is probably mainly driven by ice volume and subordinately by the summer solar insolation difference between mid‐latitude land and low‐latitude ocean.

Genetic architecture of leaf morphological and physiological traits in a Populus deltoides ‘Danhong’ × P. simonii ‘Tongliao1’ pedigree revealed by quantitative trait locus analysis - Pei Sun; Huixia Jia; Xingqi Cheng; Yahong Zhang; Jianbo Li; Lei Zhang; Mengzhu Lu; Jin Zhang; Jianjun Hu (Tree Genetics & Genomes, 2020)

A compartmental approach to isosteviol’s disposition in Sprague-Dawley rats - Ayorinde ADEHIN; Keai Sinn TAN; Chengjuan ZOU; Zhiqiang LU; Yue LIN; Dongfang WANG; Qing CHENG; Wen TAN (Naunyn-Schmiedeberg's Archives of Pharmacology, 2020)

Optimization of Inhibitory Peptides Targeting Phosphoprotein of Rabies Virus - Yongzhong Lu; Linyue Cheng; Jie Liu (International Journal of Peptide Research and Therapeutics, 2020)

Modeling of Borehole Hydraulic Fracture Initiation and Propagation with Pre-existing Cracks Using the Displacement Discontinuity Method - Wan Cheng; Chunhua Lu; Zhidong Zhou (Geotechnical and Geological Engineering, 2020)

Short-term associations between ambient fine particulate matter pollution and hospital visits for chronic obstructive pulmonary disease in Yinzhou District, China - Cheng-yi Lin; Die Li; Jie-ming Lu; Zhe-bin Yu; Yao Zhu; Peng Shen; Meng-ling Tang; Ming-juan Jin; Hong-bo Lin; Li-ming Shui; Kun Chen; Jian-bing Wang (Environmental Science and Pollution Research, 2020)

Review of drought impacts on carbon cycling in grassland ecosystems - Tianjie Lei; Jie Feng; Cuiying Zheng; Shuguang Li; Yang Wang; Zhitao Wu; Jingxuan Lu; Guangyuan Kan; Changliang Shao; Jinsheng Jia; Hui Cheng (Frontiers of Earth Science, 2020)

A Review of Sub-lethal Neonicotinoid Insecticides Exposure and Effects on Pollinators - Chensheng Lu; Yu-Tang Hung; Q. Cheng (Current Pollution Reports, 2020)

Two-Year Observation of Fossil Fuel Carbon Dioxide Spatial Distribution in Xi’an City - Xiaohu Xiong; Weijian Zhou; Shugang Wu; Peng Cheng; Hua Du; Yaoyao Hou; Zhenchuan Niu; Peng Wang; Xuefeng Lu; Yunchong Fu (Advances in Atmospheric Sciences, 2020)

Himalayan wolf distribution and admixture based on multiple genetic markers - Geraldine Werhahn; Yanjiang Liu; Yao Meng; Chen Cheng; Zhi Lu; Luciano Atzeni; Zhixiong Deng; Shi Kun; Xinning Shao; Qi Lu; Jyoti Joshi; Adarsh Man Sherchan; et al. (Journal of Biogeography, 2020)
Aim We explore the phylogeography of Himalayan wolves using multiple genetic markers applied on a landscape‐scale dataset and relate our findings to the biogeographic history of the region. Location Himalayas of Nepal, the Tibetan Plateau of China and mountain ranges of Central Asia. Taxon Himalayan wolf (also called the Tibetan wolf), Canis lupus chanco . Methods We present a large‐scale, non‐invasive study of Himalayan wolves from across their estimated range. We analysed 280 wolf scat samples from western China, Kyrgyzstan and Tajikistan at two mtDNA loci, 17 microsatellite loci, four non‐synonymous SNPs in three nuclear genes related to the hypoxia pathway, and ZF genes on both sex chromosomes. Results Our results corroborate previous studies showing that the Himalayan wolf forms a distinct lineage adapted to high altitudes in excess of 4,000 m elevation. We found a correlation between hypoxia adaptation and the divergent Himalayan wolf mtDNA haplotype found across the Tibetan Plateau of Qinghai, the Tibetan Autonomous Region and the Nepalese Himalayas. We identified a region of admixture between Himalayan and grey wolves at the boundary of their distributions, where the Tibetan Plateau elevation gradually drops. Main Conclusion Based on multiple genetic markers, the Himalayan wolf forms a reciprocally monophyletic lineage with a unique adaptation to high altitude. We propose that the divergence of the lineage is related to past uplift of the region, and that the lineage maintains its high‐altitude niche, in part, by means of its genetic adaptation to hypoxia. We conclude that the Himalayan wolf merits taxonomic recognition and designation as an evolutionary significant unit (ESU).

First report of tobacco vein banding mosaic virus infecting Solanum lyratum Thunb in China - Jian Zhang; Yong-Yuan Cheng; Lei Yang; Xin Sun; Jing Yu; Quan-You Lu (Journal of Plant Pathology, 2020)

V3 protein encoded by mulberry crinkle leaf virus acts as a pathogenicity determinant in Nicotiana benthamiana - Quan-You Lu; Jing Yu; Yong-Yuan Cheng; Xin Sun; Lei Yang (European Journal of Plant Pathology, 2020)

Robust Output Path-Following Control of Marine Surface Vessels with Finite-Time LOS Guidance - Lu Wang; Changkui Xu; Jianhua Cheng (Journal of Marine Science and Engineering, 2020)
This paper proposes a finite-time output feedback methodology for the path-following task of marine surface vessels. First, a horizontal path-following model is established with unknown sideslip angle, unmeasured system state and system uncertainties. A hierarchical control structure is adopted to deal with the cascade property. For kinematics system design, a finite-time sideslip angle observer is first proposed, and thus the sideslip angle estimation is compensated in a nonlinear line-of-sight (LOS) guidance strategy to acquire finite-time convergence. For the heading control design, an extended state observer is introduced for the unmeasured state and equivalent disturbance estimation, based on which an output feedback backstepping approach is proposed for the desired tracking of command course angle. The global stability of the cascade system is analyzed. Simulation results validate the effectiveness of the proposed methodology.

Monitoring leaf potassium content using hyperspectral vegetation indices in rice leaves - Jingshan Lu; Tiancheng Yang; Xi Su; Hao Qi; Xia Yao; Tao Cheng; Yan Zhu; Weixing Cao; Yongchao Tian (Precision Agriculture, 2020)

Naturally Occurring Antibodies to Tau Exists in Human Blood and Are Not Changed in Alzheimer’s Disease - Zhong-Yuan Yu; Wei-Wei Li; Hai-Mei Yang; Noralyn B. Mañucat-Tan; Jun Wang; Ye-Ran Wang; Bin-Lu Sun; Zi-Cheng Hu; Li-Li Zhang; Liang Tan; Juan Deng; Yu-Hui Liu (Neurotoxicity Research, 2020)

The protective effect of uric acid in reducing TLR4/NF-κB activation through the inhibition of HMGB1 acetylation in a model of ischemia–reperfusion injury in vitro - Guan-mei Cheng; Ruo-lu Wang; Bin Zhang; Xiao-ying Deng (Molecular Biology Reports, 2020)

Mouse adaptation of the H9N2 avian influenza virus causes the downregulation of genes related to innate immune responses and ubiquitin-mediated proteolysis in mice - Jing Guo; Xinxin Gao; Baotao Liu; Yubao Li; Wenqiang Liu; Jianbiao Lu; Cheng Liu; Rui Xue; Xuyong Li (Medical Microbiology and Immunology, 2020)

RIG-I aggravates interstitial fibrosis via c-Myc-mediated fibroblast activation in UUO mice - Zhuanli Zhou; Jiayun Ni; Jingyao Li; Chuanbing Huo; Naijun Miao; Fan Yin; Qian Cheng; Dan Xu; Hongyan Xie; Panpan Chen; Peiqing Zheng; Yingying Zhang; et al. (Journal of Molecular Medicine, 2020)
Progressive tubulointerstitial fibrosis is the common final outcome for all kidney diseases evolving into chronic kidney disease (CKD), whereas molecular mechanisms driving fibrogenesis remain elusive. Retinoic acid-inducible gene-I (RIG-I), an intracellular pattern recognition receptor, is originally identified participating in immune response by recognizing virus RNA. Here, we revealed for the first time that RIG-I was induced in unilateral ureteral obstruction (UUO) and folic acid (FA) renal fibrosis models and moderate-degree renal fibrosis patients. Besides, we found RIG-I was mainly located in renal tubular epithelial cells and promoted the production and release of inflammatory cytokines, such as interleukin (IL)-1β and IL-6 through activation of NF-κB. Inflammatory cytokines released by tubular epithelial cells activated c-Myc-mediated TGF-β/Smad signaling in fibroblasts, which in turn aggravated interstitial fibrosis by promoting fibroblast activation and production of extracellular matrix components (ECM). Deficiency of RIG-I attenuated renal fibrosis by the regulation of inflammatory responses, c-Myc expression, and fibroblast activation. Besides, gene silencing of RIG-I reduced inflammatory cytokines in cultured tubular epithelial cells treated with Angiotensin II. Knockdown of c-Myc or c-Myc inhibitor blocked IL-1β-induced fibroblast activation. Collectively, our study demonstrates that RIG-I plays a significant role in the progress of renal fibrosis via regulating c-Myc-mediated fibroblast activation. Key messages • RIG-I was constantly elevated in kidneys from renal fibrotic mice. • RIG-I facilitated inflammatory cytokine production in tubular epithelial cells. • RIG-I aggravated renal fibrosis via c-Myc-mediated TGF-β/Smad activation.

Optimized trio genome sequencing (OTGS) as a first-tier genetic test in critically ill infants: practice in China - Huijun Wang; Yulan Lu; Xinran Dong; Guoping Lu; Guoqiang Cheng; Yanyan Qian; Qi Ni; Ping Zhang; Lin Yang; Bingbing Wu; Wenhao Zhou (Human Genetics, 2020)

Dynamic change of vegetation and its response to climate and topographic factors in the Xijiang River basin, China - Lu Jia; Zhan-bin Li; Guo-ce Xu; Zong-ping Ren; Peng Li; Yu-ting Cheng; Yi-xin Zhang; Bin Wang; Jia-xin Zhang; Shu Yu (Environmental Science and Pollution Research, 2020)

Lipocalin-2 Predicts Long-Term Outcome of Normotensive Patients with Acute Pulmonary Embolism - Haixu Yu; Zhuohui Liu; Jie Lu; Xinying Yang; Xin-Xin Yan; Yuhong Mi; Lu Hua; Yulin Li; Zhi-Cheng Jing; Jie Du (Cardiovascular Toxicology, 2020)

Separation and preparation of N-glycans based on ammonia-catalyzed release method - Meifang Yang; Ming Wei; Chengjian Wang; Yu Lu; Wanjun Jin; Xi Gao; Cheng Li; Langhong Wang; Linjuan Huang; Zhongfu Wang (Glycoconjugate Journal, 2020)

Evaluating the Genetic Correlations Between Left-Handedness and Mental Disorder Using Linkage Disequilibrium Score Regression and Transcriptome-Wide Association Study - Bolun Cheng; Chujun Liang; Ping Li; Li Liu; Shiqiang Cheng; Mei Ma; Lu Zhang; Xin Qi; Yan Wen; Feng Zhang (Biochemical Genetics, 2020)

Phenotypic, genetic, and molecular function of msc-2, a genic male sterile mutant in pepper (Capsicum annuum L.) - Qing Cheng; Ting Li; Yixin Ai; Qiaohua Lu; Yihao Wang; Lang Wu; Jinqiu Liu; Liang Sun; Huolin Shen (Theoretical and Applied Genetics, 2020)

Clinical and biochemical indexes from 2019-nCoV infected patients linked to viral loads and lung injury - Yingxia Liu; Yang Yang; Cong Zhang; Fengming Huang; Fuxiang Wang; Jing Yuan; Zhaoqin Wang; Jinxiu Li; Jianming Li; Cheng Feng; Zheng Zhang; Lifei Wang; et al. (Science China Life Sciences, 2020)

Chemical fingerprint and source apportionment of PM2.5 in highly polluted events of southern Taiwan - Huazhen Shen; Tsung-mou Yang; Chun-chung Lu; Chung-shin Yuan; Chung-Hsuang Hung; Chi-tsan Lin; Chia-wei Lee; Guohua Jing; Gongren Hu; Kuo-cheng Lo (Environmental Science and Pollution Research, 2020)

Asian Cities are Greening While Some North American Cities are Browning: Long-Term Greenspace Patterns in 16 Cities of the Pan-Pacific Region - Jiali Jin; Sarah E. Gergel; Yuhao Lu; Nicholas C. Coops; Cheng Wang (Ecosystems, 2020)

Analytical modeling of corroded RC columns considering flexure-shear interaction for seismic performance assessment - Ji-Gang Xu; De-Cheng Feng; Gang Wu; Demitrios M. Cotsovos; Yong Lu (Bulletin of Earthquake Engineering, 2020)

Performance Evaluation of a Novel Preclinical Micro-CT System In Vitro and In Vivo - Yi-Wen Lo; Chien-Chih Ke; Jhih-Shain Lee; Hsien-Chih Chiu; Cheng-Hsu Lu; Sih-Yu Chen; Wen-Chieh Yang; Ming-Chin Hu; Bang-Hung Yang; Wen-Sheng Huang; Ren-Shyan Liu (Journal of Medical and Biological Engineering, 2020)

Interaction between CA repeat microsatellites and HIF1α regulated the transcriptional activity of porcine IGF1 promoter - Hongwei Geng; Linlin Hao; Yunyun Cheng; Chunli Wang; Shan Huang; Wenzhen Wei; Rui Yang; Haoyang Li; Songcai Liu; Hao Yu; Huayi Lu (Journal of Applied Genetics, 2020)

Novel mutations in SPEF2 causing different defects between flagella and cilia bridge: the phenotypic link between MMAF and PCD - Chaofeng Tu; Hongchuan Nie; Lanlan Meng; Weili Wang; Haiyu Li; Shimin Yuan; Dehua Cheng; Wenbin He; Gang Liu; Juan Du; Fei Gong; Guangxiu Lu; et al. (Human Genetics, 2020)

Correction to: Associations of trace elements in blood with the risk of isolated ventricular septum defects and abnormal cardiac structure in children - Yu Zhu; Cheng Xu; Yuxi Zhang; Zongyun Xie; Yaqin Shu; Changgui Lu; Xuming Mo (Environmental Science and Pollution Research, 2020)

Antioxidant responses of Fenneropenaeus chinensis to white spot syndrome virus challenge - Yongzhong Lu; Qian Qiu; Chen Li; Linyue Cheng; Jie Liu (Aquaculture International, 2020)

PDGFRβ-targeted TRAIL specifically induces apoptosis of activated hepatic stellate cells and ameliorates liver fibrosis - Rui Li; Zhao Li; Yanru Feng; Hao Yang; Qiuxiao Shi; Ze Tao; Jingqiu Cheng; Xiaofeng Lu (Apoptosis, 2020)

Comparative analysis of four semi-analytical models for estimating chlorophyll- a concentration in case-2 waters using field hyperspectral reflectance - Xiaoman Lu; Chunyan Situ; Weichun Ma; Xiaoyan Dai; Cheng He; Linna Li; Liguo Zhou (International Journal of Remote Sensing, 2020)

The formation of the ore-bearing dolomite marble from the giant Bayan Obo REE-Nb-Fe deposit, Inner Mongolia: insights from micron-scale geochemical data - Wei Chen; Hang-Yu Liu; Jue Lu; Shao-Yong Jiang; Antonio Simonetti; Cheng Xu; Wen Zhang (Mineralium Deposita, 2020)

Sustained Release Ziprasidone Microparticles Prepared by Spray Drying with Soluplus® and Ethyl Cellulose to Eliminate Food Effect and Enhance Bioavailability - Wenjie Liu; Shanshan Wang; Wangxing Lu; Zeneng Cheng; Niyanhan Jiang (AAPS PharmSciTech, 2020)

Dynamic Detection of Thrombolysis in Embolic Stroke Rats by Synchrotron Radiation Angiography - Liping Wang; Panting Zhou; Zhihao Mu; Xiaojie Lin; Lu Jiang; Zhuo Cheng; Longlong Luo; Zhiming Xu; Jieli Geng; Yongting Wang; Zhijun Zhang; Guo-Yuan Yang (Translational Stroke Research, 2019)

Interleukin-25 in sputum as a marker of airway inflammation in children asthma - Yun Zhang; Cuifen Zhao; Xiuxia Zhao; Qingyu Kong; Mingjie Ding; Yuling Han; Xiang Ma; Lu Cheng (Science China Life Sciences, 2019)

A maize stress-responsive Di19 transcription factor, ZmDi19-1, confers enhanced tolerance to salt in transgenic Arabidopsis - Xingen Zhang; Huilin Cai; Meng Lu; Qiye Wei; Lijuan Xu; Chen Bo; Qing Ma; Yang Zhao; Beijiu Cheng (Plant Cell Reports, 2019)

Size-fractionated particle-bound heavy metals and perfluoroalkyl substances in dust from different indoor air - Xingwen Lu; Yao Cheng; Mingdeng Xiang; Tianshi Liu; Ying Guo; Fei Wang (Environmental Science and Pollution Research, 2019)

TMT-based quantitative proteomics revealed follicle-stimulating hormone (FSH)-related molecular characterizations for potentially prognostic assessment and personalized treatment of FSH-positive non-functional pituitary adenomas - Ya Wang; Tingting Cheng; Miaolong Lu; Yun Mu; Biao Li; Xuejun Li; Xianquan Zhan (EPMA Journal, 2019)

Elevation Influence on Rainfall and a Parameterization Algorithm in the Beijing Area - Linye Song; Mingxuan Chen; Feng Gao; Conglan Cheng; Min Chen; Lu Yang; Yong Wang (Journal of Meteorological Research, 2019)

Multi‐model analysis of climate impacts on plant photosynthesis in China during 2000–2015 - Hao Yan; Shao‐Qiang Wang; Jun‐Bang Wang; Yun Cao; Ling‐Ling Xu; Men‐Xin Wu; Lu Cheng; Liu‐Xi Mao; Feng‐Hua Zhao; Xian‐Zhou Zhang; Yun‐Fen Liu; Yan‐Fen Wang; et al. (International Journal of Climatology, 2019)
Differences, arising from differences in gross primary production (GPP) model structures and driving forces, have fuelled arguments concerning interannual changes of GPP in China since 2000. To better investigate the interannual variability of GPP and its covariance with climate factors in China, this study adopted a multi‐model analysis based on three GPP models (i.e., Terrestrial Ecosystem Carbon flux model [TEC], Breathing Earth System Simulator model [BESS], and MOD17 GPP model). The results show that annual GPP in China increased by 0.021–0.057 Pg C year −1 from 2000 to 2015 attributable to atmospheric‐CO 2 fertilization effects and favourable climate change, that is, increasing precipitation ( P r ) and temperature ( T a ). However, northern China and southern China had a large difference in the amplitude of these GPP changes; annual GPP increased by 0.017–0.039 Pg C year −1 in northern China but only 0.001–0.018 Pg C year −1 in southern China. Northern China and southern China occupy contrasting climate zones and this contrast produced different interannual variability of GPP through different mechanisms. Northern China has a dry climate with GPP changes sensitive to P r . As a result, more P r along with higher T a in northern China produced the strong uptrend of GPP from 2000 to 2015. In contrast, southern China has a wet climate with its GPP sensitive to solar radiation and T a . For the interval of 2000–2015, decreasing radiation plus drought exerted a negative influence on GPP in southern China. This study highlights the diverse mechanisms in which climate change affects GPP in dry and wet climate zones. A robust multi‐model analysis is preferred to reduce uncertainties arising from a single GPP model and its driving data.

Genome-wide association study of pre-harvest sprouting tolerance using a 90K SNP array in common wheat (Triticum aestivum L.) - Yulei Zhu; Shengxing Wang; Wenxin Wei; Hongyong Xie; Kai Liu; Can Zhang; Zengyun Wu; Hao Jiang; Jiajia Cao; Liangxia Zhao; Jie Lu; Haiping Zhang; et al. (Theoretical and Applied Genetics, 2019)

Recycled gypsum board acted as a mineral swelling agent for improving thermal conductivity characteristics in manufacturing of green lightweight building brick - Kung-Yuh Chiang; Huei-Ru Yen; Cheng-Han Lu (Environmental Science and Pollution Research, 2019)

The essential role of CYP2E1 in metabolism and hepatotoxicity of N,N-dimethylformamide using a novel Cyp2e1 knockout mouse model and a population study - Zhijun Wu; Qiang Liu; Lei Wang; Min Zheng; Mingyue Guan; Man Zhang; Wenjin Zhao; Chunmin Wang; Songwen Lu; Juan Cheng; Shuguang Leng (Archives of Toxicology, 2019)

Benzophenanthridine alkaloids from the roots of Thalictrum microgynum Lecoy.ex Oliv - Jie Jiang; Haoran Ma; Song Hu; Lu Cheng; Fuqian Wang; Geng Zhang (Natural Product Research, 2019)

Mapping oil palm plantation expansion in Malaysia over the past decade (2007–2016) using ALOS-1/2 PALSAR-1/2 data - Yuqi Cheng; Le Yu; Yidi Xu; Hui Lu; Arthur P. Cracknell; Kasturi Kanniah; Peng Gong (International Journal of Remote Sensing, 2019)

From Analysis of Ischemic Mouse Brain Proteome to Identification of Human Serum Clusterin as a Potential Biomarker for Severity of Acute Ischemic Stroke - Hailong Song; Hui Zhou; Zhe Qu; Jie Hou; Weilong Chen; Weiwu Cai; Qiong Cheng; Dennis Y. Chuang; Shanyan Chen; Shuwei Li; Jilong Li; Jianlin Cheng; et al. (Translational Stroke Research, 2019)

MiR-26a promotes fracture healing of nonunion rats possibly by targeting SOSTDC1 and further activating Wnt/β-catenin signaling pathway - Liang Sun; Zhong Li; Hanzhong Xue; Teng Ma; Cheng Ren; Ming Li; Yao Lu; He Sun; Kun Zhang (Molecular and Cellular Biochemistry, 2019)

Development of a Direction-Oriented Motion and Short-Sitting and Lying Tai Chi (DOM-SSLTC) Model for Function Recovery in Stroke Patients - Lian-Hui Lee; Hwai-Ting Lin; Nai-Wen Tsai; Yung-Chieh Yen; Cheng-Hsien Lu; Chun-Chung Lui; Hsien-Ming Chung; Kun-Chang Tsai; Shih-Pin Hsu; Huan-Wen Tsui (Journal of Medical and Biological Engineering, 2019)

The clinical and prognostic significance of paraoxonase-2 in gastric cancer patients: immunohistochemical analysis - Xiaohua Wang; Guifang Xu; Jingyuan Zhang; Shuaiyu Wang; Min Ji; Lei Mo; Mengxia Zhu; Jun Li; Guoren Zhou; Jianwei Lu; Cheng Chen (Human Cell, 2019)

Associations between mercury exposure and the risk of nonalcoholic fatty liver disease (NAFLD) in US adolescents - Runsen Chen; Yang Xu; Cheng Xu; Yaqin Shu; Siyu Ma; Changgui Lu; Xuming Mo (Environmental Science and Pollution Research, 2019)

The mechanism of damage in the midgut of Bombyx mori after chlorantraniliprole exposure - Jiahuan Hu; Mengxue Li; Zhengting Lu; Tingting Mao; Jian Chen; Hui Wang; Jianwei Qu; Yilong Fang; Xiaoyu Cheng; Jinxin Li; Fanchi Li; Bing Li (Ecotoxicology, 2019)

Microsomal prostaglandin E synthase 2 deficiency is resistant to acetaminophen-induced liver injury - Hu Wang; Rumeng Zhang; Yangyang Zhu; Tian Teng; Yujia Cheng; Apu Chowdhury; Jihong Lu; Zhanjun Jia; Jun Song; Xiaoxing Yin; Ying Sun (Archives of Toxicology, 2019)

A Nasal Temperature and pH Dual-Responsive In Situ Gel Delivery System Based on Microemulsion of Huperzine A: Formulation, Evaluation, and In Vivo Pharmacokinetic Study - Yifan Chen; Gang Cheng; Rongfeng Hu; Shengqi Chen; Wenjie Lu; Song Gao; Hongmei Xia; Bin Wang; Chaojie Sun; Xiangjiang Nie; Qiang Shen; Wenyou Fang (AAPS PharmSciTech, 2019)

Paeoniflorin attenuates impairment of spatial learning and hippocampal long-term potentiation in mice subjected to chronic unpredictable mild stress - Si-Cheng Liu; Wei-Yan Hu; Wei-Yuan Zhang; Lu Yang; Yan Li; Zhi-Cheng Xiao; Ming Zhang; Zhi-Yong He (Psychopharmacology, 2019)

African Orphan Crops Consortium (AOCC): status of developing genomic resources for African orphan crops - Prasad S. Hendre; Samuel Muthemba; Robert Kariba; Alice Muchugi; Yuan Fu; Yue Chang; Bo Song; Huan Liu; Min Liu; Xuezhu Liao; Sunil Kumar Sahu; Sibo Wang; et al. (Planta, 2019)

Soil fungal communities vary with invasion by the exotic Spartina alternifolia Loisel. in coastal salt marshes of eastern China - Wen Yang; Nasreen Jeelani; Lu Xia; Zhihong Zhu; Yiqi Luo; Xiaoli Cheng; Shuqing An (Plant and Soil, 2019)

Coalescence Models Reveal the Rise of the White-Bellied Rat (Niviventer confucianus) Following the Loss of Asian Megafauna - Deyan Ge; Liang Lu; Alexei V. Abramov; Zhixin Wen; Jilong Cheng; Lin Xia; Alfried P. Vogler; Qisen Yang (Journal of Mammalian Evolution, 2019)

Analysis of urinary trace element levels in general population of Wuhan in central China - Hao-Long Zeng; Chang-Wen-Bo Liu; Jie Lu; Xu Wang; Liming Cheng (Environmental Science and Pollution Research, 2019)

The Ribosomal Protein RPLP0 Mediates PLAAT4-induced Cell Cycle Arrest and Cell Apoptosis - Chun-Hua Wang; Lu-Kai Wang; Chang-Chieh Wu; Mao-Liang Chen; Ming-Cheng Lee; Yi-Ying Lin; Fu-Ming Tsai (Cell Biochemistry and Biophysics, 2019)