An enhanced method for estimating snow water equivalent in the central part of the Tibetan Plateau using raster segmentation and eigenvector spatial filtering regression model - Qi-shan Cheng; Yu-min Chen; Jia-xin Yang; Yue-jun Chen; Zhe-xin Xiong; An-nan Zhou (Journal of Mountain Science, 2022)

Elastic simulation method in an irregular polar coordinate system - Yu Yang; Qi Ran; Kang Chen; Cheng Lei; Yu-sheng Zhang; Song Han (Applied Geophysics, 2022)

In-situ radon-in-water detection for high resolution submarine groundwater discharge assessment - Shibin Zhao; Meng Li; William C. Burnett; Kai Cheng; Chunqian Li; Jinjia Guo; Songling Yu; Wen Liu; Tong Yang; Natasha T. Dimova; Guangquan Chen; Zhigang Yu; et al. (Frontiers in Marine Science, 2022)
Submarine groundwater discharge (SGD), including both land-based fresh groundwater that enters the ocean from coastal aquifers as well as recirculated seawater that is continuously recharged and discharged on the seabed, has been considered as an important component of the global water and biogenic element (e.g., nitrogen, phosphorus, silicon and carbon) sources and a significant pathway for material exchange at the land-sea interface of coastal ecosystems. Some researchers reported that SGD associated nutrient additions to coastal waters have caused unwanted ecological issues, including red tides, coastal acidification and hypoxia. Natural radon isotope ( 222 Rn, t 1/2 = 3.8 d ) is an excellent tracer for studying SGD and other oceanographic processes including air-sea gas exchange, sediment-water diffusion, and earthquake prediction. However, the conventional radon measurement methods suffer many technical disadvantages. We consequently developed a convenient submersible radon determination approach (“OUC-Rn”) using a commercial pulsed ionization chamber (PIC) radon sensor and gas extraction membrane module to produce high precision and high resolution observations. We demonstrate the radon degassing efficiency of the membrane contactor is comparable to the shower-head type air-water exchanger but is independent of operating position. The radon measurement efficiency of the PIC is 2-fold higher than the RAD7 detector and is far less influenced by moisture. We successfully deployed the system in 2.5 meters water depth over a 100 hours period in an anthropogenic influenced bay. Based on our high temporal resolution observations, the SGD flux was estimated to be 0-43.0 cm/d (mean: 25.4 ± 14.5 cm/d). The SGD fluxes pattern plotted together with the tidal variations revealed that tidal pumping may be the main force driving seawater recirculation into aquifers and thus affecting nutrient, carbon and other dissolved matters dynamics in coastal regions.

Genetic Variations and Expansion of the Blue Swimmer Crab (Portunus pelagicus) in Southeast Asia - Yu-Ming Lu; Chun-Han Shih; Po-Cheng Chen; Wei-Chieh Kao; Ying-Chou Lee; Yu-San Han; Tzong-Der Tzeng (Journal of Marine Science and Engineering, 2022)
Blue swimmer crabs (Portunus pelagicus) primarily inhabit the coastal regions of Southeast Asia. This study aimed to examine their population genetic structure, phylogeography, and historical demography by applying partial sequences to the control region in the mitochondrial DNA. The analysis focused on 6 populations comprising 166 individual samples collected from Taiwan (Kezailiao Kaohsiung (KK) and Penghu (PH)), mainland China (Xiamen (XM) and Hong Kong (HK)), Vietnam (Hanoi (VN)), and Singapore (SGP). The estimated nucleotide diversity (π) for all of the samples was 0.062, with values ranging between 0.018 (PH) and 0.045 (HK). Our study collected 116 haplotypes and classified them into lineages A and B. The XM, HK, VN, and SGP populations made up lineage A, and the PH and KK populations comprised lineage B. For each lineage, the results highlighted indications of demographic expansion. Lineage A can be traced back to the second-to-last interglacial period, while lineage B possibly originated in the last glacial period. There were significant differences in the FST values among the six populations, except for the pairs HK–XM and PH–KK. In conclusion, the phylogeography and genetic structure of P. pelagicus in Southeast Asia were potentially affected by the Pleistocene glacial cycles and human introduction. These findings further highlight the possible dispersal routes of P. pelagicus throughout Southeast Asia.

Development of UPLC-MS/MS method for determining hainanmycin in foods of animal origin - Ke-xin Chi; Hang Yu; Ya-hui Guo; Yu-liang Cheng; Yun-fei Xie; Wei-rong Yao (Food Additives & Contaminants: Part A, 2022)

The role of melatonin in tomato stress response, growth and development - Qiaoli Xie; Yu Zhang; Yingxia Cheng; Yanling Tian; Junjie Luo; Zongli Hu; Guoping Chen (Plant Cell Reports, 2022)

Monte Carlo seismic response analysis of permafrost sites: a case study - Xiaobo Yu; Rui Zhang; Yushun Cheng; Yuting Hu (Natural Hazards, 2022)

Trophinin-associated protein expression correlates with shorter survival of patients with glioma: a study based on multiple data fusion analysis - Yong Sun; Zhen Dong Liu; Run Ze Liu; Xiao Yu Lian; Xing Bo Cheng; Yu Long Jia; Bin Feng Liu; Yan Zheng Gao; Xinjun Wang (Molecular Biology Reports, 2022)

Investigation and experimental validation of curcumin-related mechanisms against hepatocellular carcinoma based on network pharmacology - Yang Chen; Qian Li; Sisi Ren; Ting Chen; Bingtao Zhai; Jiangxue Cheng; Xiaoyan Shi; Liang Song; Yu Fan; Dongyan Guo (Journal of Zhejiang University-SCIENCE B, 2022)

The Role of PpNAC187 in Pear Drought and Salt Stress - Chunhui Ma; Mingtong Li; Shaolan Yang; Xinfu Zhang; Yong Zhang; Qi Qi; Yu Zhang; Chenxia Cheng (Journal of Plant Growth Regulation, 2022)

Trochanteric Nails for the Reduction of Intertrochanteric Fractures: A Biomechanical Analysis Based on Finite Element Analysis and DIC System - Ming-Tzu Tsai; Cheng-Hung Lee; Kun-Hui Chen; Yu-Chun Yen; Chun-Hsiang Wang; Shun-Ping Wang; Kuo-Chih Su (Journal of Medical and Biological Engineering, 2022)
Purpose Intertrochanteric fractures are common among femoral fractures in the elderly population. The trochanteric nail is a standard internal fixator used in treating femoral intertrochanteric fractures. The technique of femoral fracture reduction affects the postoperative outcome. Here, we applied finite element analysis (FEA) to study mechanical effects of different reduction approaches using the trochanteric nail in treating both stable and unstable intertrochanteric fractures. Methods We combined FEA and in vitro experiments using a digital imaging correlation (DIC) technique to study effects of different alignment conditions after treating 4 cases of intertrochanteric fractures using the trochanteric nail system. A downward force of 2250 N was applied to the femoral head, and the distal end of the femur was fixed. The observed indicators were the femur displacement, together with the stress on the femur and trochanteric nail system. In addition, the displacement distribution was analyzed using DIC. Results In the case of space reduction, the force was transmitted by the trochanteric nail system, resulting in greater stress imposed on the femur or the trochanteric nail system. In the case of closed reduction, the stress was much smaller. In the case of unstable fracture reduction, closed reduction was associated with a smaller contact area at the fracture site, resulting in greater stress on both trochanter and the trochanteric nail system. Conclusion When the trochanteric nail system was used for fixation, the fracture site was well aligned, reducing the stress on the femur or the trochanteric nail.

Biomechanical Effects of Different Miniplate Thicknesses and Fixation Methods Applied in BSSO Surgery Under Two Occlusal Conditions - Bo-Tsang Tseng; Yu-Chun Yen; Chi-Sheng Cheng; Chun-Hsiang Wang; Kai-Hua Lien; Chao-Min Huang; Kuo-Chih Su (Journal of Medical and Biological Engineering, 2022)
Purpose Finite element analysis (FEA) was used to evaluate the effects of different thicknesses, numbers, and positions of the miniplate applied in bilateral sagittal split osteotomy (BSSO) under two occlusal conditions. Methods An FEA model of the mandibles was constructed and combined with different thicknesses (0.6 or 1 mm), number (one or two), positions (upper or lower) of a miniplate and was divided into six models. In addition, external forces were applied to the muscles to simulate the intercuspal position (ICP) and right unilateral molar clench. This study used the reaction force of the temporomandibular joints and the stress of the mandible as observation indexes. Results The results of this study show that, under ICP, the 0.6 mm lower model generated greater TMJ force reaction compared to the 0.6 mm upper model. The same trend was seen in the 1 mm lower model compared to the 1 mm upper model. Regarding the stress of the bone on the screw-implanted sites, under ICP, screw 10 showed greater stress than screw 2, and screw 11 showed greater stress than screw 3. The stress values of the miniplates showed, under ICP, point 1-c was greater than point 3-c, and point 1-b was greater than point 3-b. Conclusion In the case of BSSO mandibular advancement surgery, implanting the miniplate at the upper position can reduce the force on the TMJ and the stress on the distal segment of the mandible. The miniplate can also resist the tensile stress more effectively. In addition, implanting two miniplates with thinner sizes may be an alternative in clinical practice.

Biomechanical Analysis of the External Fixation in a Lumbar Fracture Model: A Finite Element Study - Yijia Liao; Yiguo Yan; Yu Kang; Wenjun Wang; Xizheng Song; Wen Peng; Haibin Fu; Huarong Chen; Cheng Wang (Journal of Medical and Biological Engineering, 2022)
Purpose This study aimed to investigate the biomechanical characteristics of the external spinal fixation for treating lumbar fracture through finite element analysis (FEA) and provide a theoretical basis for its further application. Methods Two different models of L3 fracture fixed with the external spinal fixation and the internal fixation system respectively were constructed. The ROM, maximum stresses at L3, and the screws of the two models were measured under load control. Subsequently, the applied torque, the maximum stressed at L3, L1/2, L2/3, L3/4, L4/5 discs and the screws were analyzed under displacement control. Results Under load control, the external fixation model reserved more ROM than the internal fixation model (40.4–48.0% vs 30.5–41.0%). Compared to the internal fixation model, the maximum stresses at L3 and screws in the external fixation model were increased. Under displacement control, the external fixation model required fewer moments (N·mm) than the internal fixation model (flexion: 7500 vs 12,294; extension: 7500 vs 9027). Further, the maximum stresses at L3 and the screws in the external fixation model were greater than those of the internal fixation model, while the maximum stresses at the upper and lower adjacent discs of fixed segments were less than the internal fixation model. Conclusion Compared to the internal fixation system, the external fixation has a better stress distribution with the greater overall mobility. It theoretically reduces the stress concentration of the adjacent discs and the stress shielding of the fractured vertebral body.

Invasion Intensity Modulates the Allelopathic Impact of Solidago canadensis L. Leaves and Roots Against Lactuca sativa L. During Germination and Early Seedling Stage - Youli Yu; Huiyuan Cheng; Zhelun Xu; Shanshan Zhong; Congyan Wang; Erhui Guo (International Journal of Environmental Research, 2022)

Modification effects of seasonal and temperature variation on the association between exposure to nitrogen dioxide and ischemic stroke onset in Shenzhen, China - Yuchen Tian; Ming Xiang; Ji Peng; Yanran Duan; Ying Wen; Suli Huang; Lei Li; Shuyuan Yu; Jinquan Cheng; Xia Zhang; Peng Wang (International Journal of Biometeorology, 2022)

High-density genetic map and quantitative trait loci map of fruit-related traits in wax gourd (Benincasa hispida) - Liwen Su; Jiquan Gou; Haixuan Lv; Zhikui Cheng; Lianlian Ma; Xiaochun Huang; Wenting Wu; Wenjin Yu; Peng Wang; Zhengguo Liu (Euphytica, 2022)

Allergy from perspective of environmental pollution effects: from an aspect of atopic dermatitis, immune system, and atmospheric hazards—a narrative review of current evidences - Su Boon Yong; Shuo-Yan Gau; Yu-Chen Guo; James Cheng-Chung Wei (Environmental Science and Pollution Research, 2022)

The role of estrogen receptor β in fine particulate matter (PM2.5) organic extract-induced pulmonary inflammation in female and male mice - Huaqi Guo; Hengyi Yu; Yan Feng; Wei Cheng; Yan Li; Yan Wang (Environmental Science and Pollution Research, 2022)

Environmental thiocyanate exposure was associated with oral health-related productivity loss among US adults: results from NHANES - Jintao Yu; Jiawen Guo; Hengguo Zhang; Xu Cheng (Environmental Science and Pollution Research, 2022)

Association of caffeine and caffeine metabolites with obesity among children and adolescents: National Health and Nutrition Examination Survey (NHANES) 2009–2014 - Linling Yu; Hong Mei; Da Shi; Xing Wang; Man Cheng; Lieyang Fan; Yang Xiao; Ruyi Liang; Bin Wang; Meng Yang; Weihong Chen (Environmental Science and Pollution Research, 2022)

Investigation of microplastic pollution in Arctic fjord water: a case study of Rijpfjorden, Northern Svalbard - Mengrong Bao; Qinghui Huang; Zhibo Lu; France Collard; Minggang Cai; Peng Huang; Yong Yu; Shuiping Cheng; Lihui An; Anette Wold; Geir Wing Gabrielsen (Environmental Science and Pollution Research, 2022)

Traffic noise and adiposity: a systematic review and meta-analysis of epidemiological studies - Si-Yu Gui; Ke-Jia Wu; Yue Sun; Yue-Nan Chen; Huan-Ru Liang; Wen Liu; Yao Lu; Cheng-Yang Hu (Environmental Science and Pollution Research, 2022)

Assessment of brain connectome alterations in male chronic smokers using structural and generalized q-sampling MRI - Jun-Cheng Weng; Yu-Chen Chuang; Li-Bang Zheng; Ming-Shih Lee; Ming-Chou Ho (Brain Imaging and Behavior, 2022)

Cohnella mopanensis sp. nov., a new Gram-negative bacterium isolated from soil in Xinping Mountain National Forest Park - Jing Tang; Jiang-Yuan Zhao; Le-Le Li; Zhang-Gui Ding; Shi-Qiang Ye; Cheng Ling; Meng-Yu Zhang; Song-Guo Liang; Jian-Yu Li; Pei-Wen Yang; Jiao Xiong; Lu-Yao Feng; et al. (Archives of Microbiology, 2022)

The effects of dietary fermented wheat bran polysaccharides on mucosal and serum immune parameters, hepatopancreas antioxidant indicators, and immune-related gene expression of common carp (Cyprinus carpio) juveniles - Rui-Fang Wang; Yuan Wang; Jun Zhang; Mei-Qi Weng; Yu-Hui Liu; Qiu-Yan Cheng; Min Song; Yan-Ping Yang; Xiao-Ping An; Jing-Wei Qi (Aquaculture International, 2022)

Oblique strike-slip superimposed structure in Yingxiong range, western Qaidam basin and its response to Altyn Tagh fault and Eastern Kunlun fault - Xiang Cheng; Zhaojie Guo; Yan Chen; Xiangjiang Yu; Wei Du; Jiawei Wu; Haifeng Wang; Caifang Wu (International Geology Review, 2022)

Isolation and identification of two new sargentodoxosides from Sargentodoxa cuneata and their agonistic effects against FXR - Wen Zhang; Cheng-Peng Sun; Yu-Lin Peng; Wen-Yu Zhao; Zheng-Yue Wang; Jing Ning; Xia Lv; Zhen-Long Yu; Shuang Zhou; Wei Peng; Bang-Jiang Fang; Xiao-Chi Ma (Natural Product Research, 2022)

Heterologous expression, refolding, and characterization of a calcium-independent phospholipase A1 from Streptomyces albidoflavus - Shi Cheng; Zitao Guo; Chaojuan Liang; Yi Shi; Peng Geng; Yu Xin; Zhenghua Gu; Liang Zhang (Systems Microbiology and Biomanufacturing, 2022)

Temporal dynamics of fine root production, mortality and turnover deviate across branch orders in a larch stand - Changfu Huo; Jiacun Gu; Lizhong Yu; Peng Wang; Weixin Cheng (Oecologia, 2022)

Correction to: Matrine Treatment Blocks NogoA-Induced Neural Inhibitory Signaling Pathway in Ongoing Experimental Autoimmune Encephalomyelitis - Quan-Cheng Kan; Hui-Jun Zhang; Yuan Zhang; Xing Li; Yu-Ming Xu; Rodolfo Thome; Ming-Liang Zhang; Nan Liu; Yao-Juan Chu; Guang-Xian Zhang; Lin Zhu (Molecular Neurobiology, 2022)

Air pollution associated with cognitive decline by the mediating effects of sleep cycle disruption and changes in brain structure in adults - Chen-Chen Lo; Wen-Te Liu; Yueh-Hsun Lu; Dean Wu; Chih-Da Wu; Ting-Chieh Chen; Yu-Ting Fang; Yu-Chun Lo; You-Yin Chen; Lo Kang; Cheng-Yu Tsai; Yueh-Lun Lee; et al. (Environmental Science and Pollution Research, 2022)

The impacts of ambient relative humidity and temperature on supine position-related obstructive sleep apnea in adults - Wen-Te Liu; Yuan-Hung Wang; Li-Te Chang; Chih-Da Wu; Dean Wu; Cheng-Yu Tsai; Chen-Chen Lo; Kang Lo; Kian Fan Chung; Ta-Yuan Chang; Kai-Jen Chuang; Yueh-Lun Lee; et al. (Environmental Science and Pollution Research, 2022)

Short-term effect of sulfur dioxide (SO2) change on the risk of tuberculosis outpatient visits in 16 cities of Anhui Province, China: the first multi-city study to explore differences in occupational patients - Xin-Qiang Wang; Jia-Wen Zhao; Kang-Di Zhang; Wen-Jie Yu; Jie Wang; Ying-Qing Li; Xin Cheng; Zhen-Hua Li; Yi-Cheng Mao; Cheng-Yang Hu; Kai Huang; Kun Ding; et al. (Environmental Science and Pollution Research, 2022)

Influence of accelerometer type on uncertainties in recorded ground motions and seismic damage assessment - Wenjie Liao; Yifan Fei; Farid Ghahari; Wenyang Zhang; Peng-Yu Chen; Asli Kurtulus; Chu-Han Yen; Qingle Cheng; Xinzheng Lu; Ertugrul Taciroglu (Bulletin of Earthquake Engineering, 2022)

Research on the layout optimization and utilization of floor gas extraction roadway: a case study in Shoushan No.1 Coal Mine, China - Xiong Ding; Cheng Zhai; Jizhao Xu; Xu Yu; Yong Sun; Yuzhou Cong; Yangfeng Zheng; Wei Tang (Arabian Journal of Geosciences, 2022)

Understanding the social impacts of enforcement activities on illegal wildlife trade in China - Sifan Hu; Yu Cheng; Rong Pan; Fasheng Zou; Tien Ming Lee (Ambio, 2022)
Illegal wildlife trade enforcement is a cornerstone conservation strategy worldwide, yet we have a limited understanding on its social impacts. Using Chinese online wildlife seizure news (2003–2018), we evaluated the interactions among enforcement operations, news frequency, and social engagement (i.e., whistle-blowing) frequency. Our results showed that intensive enforcement operations, which commenced after 2012, have social impacts by increasing the frequency of all seizure news significantly by 28% [95% Confidence Interval (CI): 5%, 51%] and those via whistle-blowing by 24% [95% CI: 2%, 45%], when compared to counterfactual models where possible confounding factors were accounted for. Furthermore, we revealed the potential interaction between enforcement seizure news with and without social engagement, and the consequential social feedback process. Of the species identified from ‘whistle-blowing’ news, up to 28% are considered as high conservation priorities. Overall, we expanded our understanding of the enforcement impacts to social dimensions, which could contribute to improving the cost-effectiveness of such conservation efforts.

The effect of meteorological drought on vegetation cover in the Yellow River basin, China - Lu Jia; Kun‐xia Yu; Zhan‐bin Li; Peng Li; Guo‐ce Xu; Yu‐ting Cheng; Xiang Zhang; Zhi Yang (International Journal of Climatology, 2022)
As a widespread natural disaster, drought has a significant impact on changes in regional vegetation cover. Based on 1‐month standardized precipitation index (SPI1), this study took the Yellow River basin (YRB) with frequent droughts as the research object, using NDVI data from 1999 to 2018, Mann–Kendall trend test, and correlation test to study the temporal and spatial characteristics of meteorological drought, explored the response of vegetation cover to meteorological drought, and further discussed the possible factors affecting meteorological drought. The results of the study showed that from 1999 to 2018, the SPI1 in the YRB had not increased significantly in a large area in different months ( p > .05). On the monthly time scale, the NDVI of the YRB gradually increased from north to south, showing a significant increasing trend the central area ( p p p

Investment Feasibility Analysis of Large Submersible Cage Culture in Taiwan: A Case Study of Snubnose Pompano (Trachinotus anak) and Cobia (Rachycentron canadum) - Hsun-Yu Lan; Farok Afero; Cheng-Ting Huang; Bo-Ying Chen; Po-Lin Huang; Yen-Lung Hou (Fishes, 2022)
Onshore farming for premium aquaculture is under scrutiny and criticism partially due to possible causes of adverse environmental impacts on other resource users and the surrounding environment. The best alternative to preventing or minimizing these impacts is to utilize open seawater by large submersible cage culture. The current operation in Taiwan has demonstrated that the culture operation is technically feasible but economically demanding because of high capital and operating costs. Therefore, this study conducted an economic analysis of the expansion of large submersible cage culture by selecting two premium species of snubnose pompano (Trachinotus anak) and cobia (Rachycentron canadum) and examined the profitability of large submersible cage culture investment. This study found that the current operation of four-unit cages highlighted a negative net present value and internal rate of return with a payback period of over ten and six years, respectively. Large submersible cage culture can be financially profitable when its operation unit expands from 8 to 24 units. Increasing unit cages to eight incurred a gross margin of 17.09%, BCR 1.21, with a payback period of 5.36 years. Expanding the operation to 24-unit cages was a potentially lucrative investment with a gross margin of 18.51%, BCR 1.23, PI 2.15, internal rate of return of 20.84%, and a payback period of 3.55 years. Sensitivity analyses revealed that market price and survival rate significantly impact the profitability of large submersible cage culture. Finally, it is suggested that producers could invest in 8-unit cages and maintaining the survival rate of snubnose pompano and cobia at 80% and 40%, respectively.

A Cycle of Wind-Driven Canyon Upwelling and Downwelling at Wilmington Canyon and the Evolution of Canyon-Upwelled Dense Water on the MAB Shelf - Haixing Wang; Donglai Gong; Marjorie A. M. Friedrichs; Courtney K. Harris; Travis Miles; Hao-Cheng Yu; Yinglong Zhang (Frontiers in Marine Science, 2022)
Submarine canyons provide a conduit for shelf-slope exchange via topographically induced processes such as upwelling and downwelling. These processes in the Wilmington Canyon, located along the shelf-break of the Mid-Atlantic Bight (MAB), have not been previously studied, and the associated hydrographic variability inside the canyon and on the adjacent shelf are largely unknown. Observations from an underwater glider deployed in Wilmington Canyon (February 27 - March 8, 2016), along with wind and satellite altimetry data, showed evidence for a wind-driven canyon upwelling event followed by a subsequent downwelling event. Next, a numerical model of the MAB was developed to more fully represent these two events. Modeled results showed that under upwelling-favorable winds during February 25 - March 3, sea level increased seaward, shelf currents flowed northeastward, and canyon upwelling developed. Then under downwelling-favorable winds during March 4-7, sea level increased landward, shelf currents flowed southwestward, and canyon downwelling developed. Modeling experiments showed that canyon upwelling and downwelling were sub-tidal processes driven by winds and pressure gradients (associated with SSH gradients), and they would occur with or without tidal forcing. During the upwelling period, slope water originating from 150-215 m depths within the canyon (75 m below the canyon rim), was advected onto the shelf, forming a cold and dense canyon-upwelled slope-originated overflow water at the bottom of the outer shelf (75-150 m isobaths). The dense overflow current flowed was directed northeastward and expanded in the cross-shelf direction. It was 5-20 km wide and 10-30 m thick. The estimated volume of the plume overflow water exceeded 6×10 9 m 3 at peak. The density front at the shoreward side of the dense overflow water caused a subsurface baroclinic frontal jet, which flowed northeastward and along-shelf with maximum speed exceeding 0.5 m/s. In the ensuing downwelling event, a portion of the previously upwelled dense water was advected back to the canyon, and then flowed down-slope in the upper canyon in ~0.3 m/s bottom-intensified currents. Dynamical investigation of the overflow current showed that its evolution was governed by unbalanced horizontal pressure gradient force in the cross-shelf direction and that the current was geostrophic.

An Improved Discontinuous Deformation Analysis to Solve Numerical Creep Problem in Shear Direction - Pengcheng Yu; Xinyan Peng; Yingbin Zhang; Dejian Li; Haiying Fu; Yin Cheng (Rock Mechanics and Rock Engineering, 2022)

Lactobacillus plantarum PS128 Promotes Intestinal Motility, Mucin Production, and Serotonin Signaling in Mice - Chih-Ming Chen; Chien-Chen Wu; Chin-Lin Huang; Min-Yu Chang; Shih-Hsuan Cheng; Ching-Ting Lin; Ying-Chieh Tsai (Probiotics and Antimicrobial Proteins, 2022)
Lactobacillus plantarum PS128 has been reported as a psychobiotic to improve mental health through the gut–brain axis in experimental animal models. To explore its mechanism of action in the gut, this study aimed to analyze the effects of L. plantarum PS128 ingestion on naïve and loperamide (Lop)-induced constipation mice. We found that, in the two mouse models, the weight, number, and water content of feces in the L. plantarum PS128 group were higher than those in the vehicle control group. Histological observation revealed that L. plantarum PS128 increased the level of colonic mucins including the major mucin MUC2. In addition, the charcoal meal test showed that L. plantarum PS128 significantly increased the small intestine transit in naïve mice, but not in the Lop-treated mice. Since intestinal serotonin has been found to modulate motility, we further analyzed the expression of genes related to serotonin signal transduction in the small intestine of naïve mice. The results showed that L. plantarum PS128 significantly altered the expression levels of Tph1 , Chga , Slc6a4 , and Htr4 , but did not affect the expression levels of Tph2 , Htr3a , and Maoa . Furthermore, immunohistochemistry revealed that L. plantarum PS128 significantly increased the number of serotonin-containing intestinal cells in mice. Taken together, our results suggest that L. plantarum PS128 could promote intestinal motility, mucin production, and serotonin signal transduction, leading to a laxative effect in mice.

Molecular Mechanism of Selenium Affecting the Synthesis of Flavonoids in G. biloba Leaves - Kun Deng; Li Li; Linling Li; Feng Xu; Honghui Yuan; Sanxing Zha; Xian Xiao; Jie Yu; Shuiyuan Cheng; Hua Cheng (Plant Molecular Biology Reporter, 2022)

Quantitative physical model of vulnerability of buildings to urban flow slides in construction solid waste landfills: a case study of the 2015 Shenzhen flow slide - Hualin Cheng; Zhiyi Chen; Yu Huang (Natural Hazards, 2022)

CircRFX3 Up-regulates Its Host Gene RFX3 to Facilitate Tumorigenesis and Progression of Glioma - Yu Qian; Baochun Cheng; Jing Luo; Yangchun Hu; Lu Gao; Hongwei Cheng (Journal of Molecular Neuroscience, 2022)

Use of piggyBac Transposon System Constructed Murine Breast Cancer Model for Reporter Gene Imaging and Characterization of Metastatic Tumor Cells - Ying-Ling Chen; Yung-Cheng Wang; Kuei-Yuan Hou; Min-Ying Lin; Yu-Chuan Lin; Hui-Yen Chuang; Yi-Jang Lee (Journal of Medical and Biological Engineering, 2022)

Detection of bloom-forming dinoflagellates Karenia mikimotoi and Prorocentrum donghaiense using qPCR assays - Xiao-Kun Hu; Zhuo-Ru Lin; Qing-Chun Zhang; Fan-Zhou Kong; Jing-Yi Cen; Yu-Lan Zeng; Ren-Cheng Yu (Journal of Applied Phycology, 2022)

Particle size rather than concentration of silver nanoparticles mainly affects soil N2-fixing bacterial communities - Y. Yu; H. Cheng; J. Zhou; S. Wang; M. Wei; C. Wang (International Journal of Environmental Science and Technology, 2022)

DeepStack-DTIs: Predicting Drug–Target Interactions Using LightGBM Feature Selection and Deep-Stacked Ensemble Classifier - Yan Zhang; Zhiwen Jiang; Cheng Chen; Qinqin Wei; Haiming Gu; Bin Yu (Interdisciplinary Sciences: Computational Life Sciences, 2022)

Prediction of disability-free survival in healthy older people - Johannes Tobias Neumann; Le T. P. Thao; Anne M. Murray; Emily Callander; Prudence R. Carr; Mark R. Nelson; Rory Wolfe; Robyn L. Woods; Christopher M. Reid; Raj C. Shah; Anne B. Newman; Jeff D. Williamson; et al. (GeroScience, 2022)
Prolonging survival in good health is a fundamental societal goal. However, the leading determinants of disability-free survival in healthy older people have not been well established. Data from ASPREE, a bi-national placebo-controlled trial of aspirin with 4.7 years median follow-up, was analysed. At enrolment, participants were healthy and without prior cardiovascular events, dementia or persistent physical disability. Disability-free survival outcome was defined as absence of dementia, persistent disability or death. Selection of potential predictors from amongst 25 biomedical, psychosocial and lifestyle variables including recognized geriatric risk factors, utilizing a machine-learning approach. Separate models were developed for men and women. The selected predictors were evaluated in a multivariable Cox proportional hazards model and validated internally by bootstrapping. We included 19,114 Australian and US participants aged ≥65 years (median 74 years, IQR 71.6–77.7). Common predictors of a worse prognosis in both sexes included higher age, lower Modified Mini-Mental State Examination score, lower gait speed, lower grip strength and abnormal (low or elevated) body mass index. Additional risk factors for men included current smoking, and abnormal eGFR. In women, diabetes and depression were additional predictors. The biased-corrected areas under the receiver operating characteristic curves for the final prognostic models at 5 years were 0.72 for men and 0.75 for women. Final models showed good calibration between the observed and predicted risks. We developed a prediction model in which age, cognitive function and gait speed were the strongest predictors of disability-free survival in healthy older people. Trial registration Clinicaltrials.gov (NCT01038583)

Assessment of urban river water pollution with urbanization in East Africa - Sophia Shuang Chen; Ismael Aaron Kimirei; Cheng Yu; Qiushi Shen; Qun Gao (Environmental Science and Pollution Research, 2022)
Anthropogenic pollution plays an important part in deteriorating the water quality of rivers all over the world, especially in urban areas of Africa where water quality monitoring is still seriously constrained by the limited test facility and capability. In this study, for evaluating the impact of urbanization on the river water quality, we investigated four typical urban rivers of Tanzania through the upper-urban-down gradient assessment approach and analyzed by water quality index (WQI) and statistical methods. The physicochemical indices monitored in these rivers revealed that the contents of those indicators of TN, TP, PO 4 3− , NH 4 + , COD Mn , and NO 3 − were accumulated significantly in the lower reaches of the cities, which indicated the life-type pollution characteristics in such urban rivers of Africa. The following main conclusions are achieved from this study. The water quality of 30% of the investigated river sections is in the medium to good status based on the subjective WQI with sensory factors included. Moreover, the sections with obvious water quality decline are mainly limited to the river segments within the urban central area, and severe pollution of water bodies is closely related to large cities, indicating an increasing pollution tendency with the quickly growing population. Therefore, to help formulate water pollution control policies in response to the rapid urban expansion in African countries, it is necessary to adopt an economical and feasible method to carry out early monitoring of surface water quality timely.

Comparison of Different Chemical Extraction Methods for Predicting the Bioavailability and Phytotoxicity of Soil PAEs to Green Vegetables (Brassica Rapa Var. Chinensis) - Jinjin Cheng; Xiaolong Chen; Lili Tian; Qun Wan; Xiangyang Yu (Bulletin of Environmental Contamination and Toxicology, 2022)

Limit state analysis of stepped sliding of jointed rock slope based on tensile-shear composite failure mode of rock bridges - Dejian Li; Wentao Jia; Xiao Cheng; Lianheng Zhao; Yingbin Zhang; Pengcheng Yu (Bulletin of Engineering Geology and the Environment, 2022)

Estrogen Deficiency Aggravates Fluoride-Induced Liver Damage and Lipid Metabolism Disorder in Rats - Ya-ming Yu; Bian-hua Zhou; Yi-lin Yang; Cheng-Xiang Guo; Jing Zhao; Hong-wei Wang (Biological Trace Element Research, 2022)

Flow-slide characteristics and failure mechanism of shallow landslides in granite residual soil under heavy rainfall - Hui-lin Bai; Wen-kai Feng; Shuang-quan Li; Long-zhen Ye; Zhong-teng Wu; Rui Hu; Hong-chuan Dai; Yun-peng Hu; Xiao-yu Yi; Peng-cheng Deng (Journal of Mountain Science, 2022)

Deep learning of DEM image texture for landform classification in the Shandong area, China - Yuexue Xu; Hongchun Zhu; Changyu Hu; Haiying Liu; Yu Cheng (Frontiers of Earth Science, 2022)

Alteromonas oceanisediminis sp. nov., isolated from deep-sea sediment - Xiao-Yu Zhang; Zhen Wang; Jun-Hui Cheng; Hui-Hui Fu; Yu-Zhong Zhang; Xiu-Lan Chen; Xi-Ying Zhang; Xiao-Yan Song; Yu-Qiang Zhang; Fei Xu (Archives of Microbiology, 2022)

Geographic distance, sedimentation, and substrate shape cryptic crustose coralline algal assemblages in the world’s largest subtropical intertidal algal reef - Shing Hei Zhan; Ling Chen; Chen‐Pan Liao; Wun‐Ruei Chang; Cheng‐Chin Li; Guang‐You Tang; Ching‐Yu Liou; Wei‐Lung Wang; Shih‐Wei Wang; Shao‐Lun Liu (Molecular Ecology, 2022)
Algal reefs, concreted by crustose coralline algae (CCA), are the main biotic reefs in temperate waters but rare in the subtropics and tropics. The world's largest known intertidal algal reef in the subtropics is the Taoyuan Algal Reef (TAR) located in the northwestern coast of Taiwan. The biodiversity and ecology of the TAR are scarcely explored, and now the reef is imperiled by industrialization. Here, we document cryptic species of CCA in Taiwan, particularly the TAR, by sequencing the psb A genes of over 1800 specimens collected across Taiwan. We also examine the ecological background of the TAR by surveying its benthic composition and measuring its environmental parameters. Our data reveal that the TAR harbours a high diversity of cryptic CCA species (27 molecular operational taxonomic units, or mOTUs), many of which are potentially new to science (18 mOTUs) and/or endemic to the TAR (9 mOTUs). Comparing the CCA species inventory of the TAR with the rest of Taiwan shows that the TAR represents a unique hotspot of CCA taxa in the waters of Taiwan. Our analyses show that variation in the CCA assemblages in the TAR is associated with geographic distance, sedimentation, and substrate type (for example, reef vs. hermit crab shell), suggesting that dispersal limitation and contemporary environmental selection shape the CCA assemblages in the TAR. The data from this study can inform the monitoring of human impacts on the health of the TAR and contribute to our understanding of the ecological processes underlying algal reef development.

Quinoline, with the active site of 8‐hydroxyl, efficiently inhibits Micropterus salmoides rhabdovirus (MSRV) infection in vitro and in vivo - Bo‐Yang Li; Fei Yang; Zhong‐Yu Zhang; Yu‐Feng Shen; Tao Wang; Liang Zhao; Jia‐Cheng Qin; Fei Ling; Gao‐Xue Wang (Journal of Fish Diseases, 2022)
Micropterus salmoides rhabdovirus (MSRV) is an significant pathogen that causes high mortality and related economic losses in bass aquaculture. There is no effective or approved therapy to date. In this study, we evaluated the anti‐MSRV effects of 22 quinoline derivatives in grass carp ovary (GCO) cells. Among these compounds, 8‐hydroxyquinoline exhibited valid inhibition in decreasing MSRV nucleoprotein gene expression levels of 99.3% with a half‐maximal inhibitory concentrations (IC 50 ) value of 4.66 μM at 48 h. Moreover, 8‐hydroxyquinoline significantly enhanced a protective effect in GCO cells by reducing the cytopathic effect (CPE). By comparing the anti‐MSRV activity of 22 quinoline derivatives, we found that 8‐hydroxyquinoline possessed the efficient active site of 8‐hydroxyl and inhibited MSRV infection in vitro. For in vivo studies, 8‐hydroxyquinoline via intraperitoneal injection exhibited an antiviral effect in MSRV‐infected largemouth bass by substantially enhancing the survival rate by 15.0%. Importantly, the viral loads in the infected largemouth bass notably reduced in the spleen on the third days post‐infection. Overall, 8‐hydroxyquinoline was considered to be an efficient agent against MSRV in aquaculture.

Volcanic rocks of the Elashan Formation in the Dulan-Xiangride Basin, East Kunlun Orogenic Belt, NW China: Petrogenesis and implications for Late Triassic geodynamic evolution - Xingzhu Fan; Fengyue Sun; Chenghan Xu; Dongqian Wu; Lu Yu; Li Wang; Cheng Yan; Shahzad Bakht (International Geology Review, 2022)

A new highly oxygenated germacranolide from Carpesium nepalense var. lanatum (C.B.Clarke) Kitam - Yi-Fan Yu; Yue-Qian Li; Ru-Yue Wang; Xu Liu; Wen-Bo Cui; Xiao-Han Chen; Cheng-Mu Zhao; Feng-Ming Qi; Zhan-Xin Zhang; Dong-Qing Fei (Natural Product Research, 2022)

Impact of Microstructure on Solar Radiation Transfer Within Sea Ice During Summer in the Arctic: A Model Sensitivity Study - Miao Yu; Peng Lu; Bin Cheng; Matti Leppäranta; Zhijun Li (Frontiers in Marine Science, 2022)
The recent rapid changes in Arctic sea ice have occurred not only in ice thickness and extent, but also in the microstructure of ice. To understand the role of microstructure on partitioning of incident solar shortwave radiation within the ice and upper ocean, this study investigated the sensitivity of the optical properties of summer sea ice on ice microstructures such as the volume fraction, size, and vertical distribution of gas bubbles, brine pockets, and particulate matter (PM). The results show that gas bubbles are the predominant scatterers within sea ice. Their effects on the scattering coefficient and ice albedo are 5 and 20 times stronger respectively than the effect of brine pockets. Albedo and transmittance of ice decrease with higher concentration and larger size of PM particles. A 4-cm top layer of ice with high PM concentration (50 g/m 3 ) results in a 10% increase in radiation absorption. The role of ice microstructure in the partitioning of radiation transfer is more important for seasonal than for multiyear ice, and more important for ponded than for snow-covered ice. Varying ice microstructure can obviously alter solar radiation transfer in the ice-ocean system, even with a constant ice thickness. Our results suggest that numerical models should take the variable microstructure of sea ice into account to improve model accuracy and to understand the interaction between internal variations in Arctic sea ice and the ocean, especially in summer.

Selective ensemble deep bidirectional RVFLN for landslide displacement prediction - Xiaoyang Yu; Cheng Lian; Yixin Su; Bingrong Xu; Xiaoping Wang; Wei Yao; Huiming Tang (Natural Hazards, 2022)

Interleukin-6 transiently promotes proliferation of osteoclast precursors and stimulates the production of inflammatory mediators - Peng-Yuan Chang; Hung-Kang Wu; Yu-Hsu Chen; Yu-Pao Hsu; Ming-Te Cheng; Ching-Hsiao Yu; Shau-Kwaun Chen (Molecular Biology Reports, 2022)

Genome-wide association analysis discovered new loci and candidate genes associated with low-phosphorus tolerance based on shoot mineral elements concentrations in soybean - Qing Wang; Wenkai Du; Wenqing Yu; Weihao Zhang; Fang Huang; Hao Cheng; Deyue Yu (Molecular Genetics and Genomics, 2022)

A deep learning-based approach to automatic proximal femur segmentation in quantitative CT images - Yu Deng; Ling Wang; Chen Zhao; Shaojie Tang; Xiaoguang Cheng; Hong-Wen Deng; Weihua Zhou (Medical & Biological Engineering & Computing, 2022)

The Effects of Ground and Treadmill Running on Energy Metabolism and Muscle Contractile Properties: A Randomized Cross-Over Study - Yuan Zhou; Jian-gang Chen; Xiao-long Li; Xin-liang Pan; Yi-zheng Zhou; Zheng-ao Li; Zhi-cheng Liang; Jia-min Long; Ming-ze Qin; Jing Zhang; Bing Shi; Bing-jun Wan; et al. (Journal of Science in Sport and Exercise, 2022)
Purpose This study aimed to compare the effects of ground and treadmill running on energy metabolism and muscle contractile properties, providing a basis for the general public to choose running venues. Methods Ten male college students (age, 20.10 ± 1.53 years; height, 176.20 ± 5.49 cm; weight, 72.14 ± 8.25 kg; body fat percent, 12.41% ± 4.65%) were recruited in this study. Energy expenditure (EE) was measured using the accelerometer (GT9X) combined with specific estimation equations. Average heart rate (HR) was measured using a heart rate band (Polar). Muscle contractile properties were assessed by measuring muscle displacement (Dm) and contraction velocity (Vc) using tensiomyography (TMG-S1). Blood glucose (Glu) and lactate (Lac) were measured by portable devices (eB-G and Lactate Scout). The running speed was 9 km/h and the duration was 25 min. Two-way ANOVA (protocol × time) was used to analyze the effect of running protocols on energy metabolism and muscle contractile properties. Results EE of treadmill running was significantly higher than EE of ground running (protocol main effect, P < 0.001), and HR of treadmill running was significantly higher than that of ground running in the first testing time (protocol simple effect, P = 0.026; protocol × time interaction P = 0.043). The decrease in Dm of the rectus femoris after treadmill running was significantly higher than that of ground running (protocol main effect, P = 0.009). The interaction of different running protocols and testing times on Lac was significant ( P = 0.025), but all results of the simple effects analysis were not statistically significant ( P > 0.05). Conclusion Our study found a difference in energy expenditure between treadmill and ground running at 9 km/h with duration of 25 min. In addition, treadmills are more likely to cause a decrease in muscle displacement distance of the rectus femoris measured after exercise than ground running. Future studies are needed to further investigate whether the differences are induced by internal metabolism or the environmental conditions of running.

Comparative transcriptomics and multiple phytohormone profiling reveals the molecular immune response of Arabidopsis thaliana to the pathogen Ralstonia solanacearum type III effector RipN - Zhangyong Dong; Xiaoying Zheng; Yongxin Shu; Zhen Meng; Jie Zhang; Lina Xiong; Ping Cheng; Guohui Yu; Yunhao Sun (Journal of Plant Pathology, 2022)

Identification of PDXDC1 as a novel pleiotropic susceptibility locus shared between lumbar spine bone mineral density and birth weight - Yu-Qian Song; Shi-Di Hu; Xu Lin; Xiang-He Meng; Xiao Wang; Yin-Hua Zhang; Cheng Peng; Rui Gong; Tao Xu; Tong Zhang; Chen-Zhong Li; Dao-Yan Pan; et al. (Journal of Molecular Medicine, 2022)
An increasing number of epidemiological studies have suggested that birth weight (BW) may be a determinant of bone health later in life, although the underlying genetic mechanism remains unclear. Here, we applied a pleiotropic conditional false discovery rate (cFDR) approach to the genome-wide association study (GWAS) summary statistics for lumbar spine bone mineral density (LS BMD) and BW, aiming to identify novel susceptibility variants shared between these two traits. We detected 5 novel potential pleiotropic loci which are located at or near 7 different genes ( NTAN1 , PDXDC1 , CACNA1G , JAG1 , FAT1P1 , CCDC170 , ESR1 ), among which PDXDC1 and FAT1P1 have not previously been linked to these phenotypes. To partially validate the findings, we demonstrated that the expression of PDXDC1 was dramatically reduced in ovariectomized (OVX) mice in comparison with sham-operated (SHAM) mice in both the growth plate and trabecula bone. Furthermore, immunohistochemistry assay with serial sections showed that both osteoclasts and osteoblasts express PDXDC1 , supporting its potential role in bone metabolism. In conclusion, our study provides insights into some shared genetic mechanisms for BMD and BW as well as a novel potential therapeutic target for the prevention of OP in the early stages of the disease development. Key messages We investigated pleiotropy-informed enrichment between LS BMD and BW. We identified genetic variants related to both LS BMD and BW by utilizing a cFDR approach. PDXDC1 is a novel pleiotropic gene which may be related to both LS BMD and BW. Elevated expression of PDXDC1 is related to higher BMD and lower ratio n-6/n-3 PUFA indicating a bone protective effect of PDXDC1.

QTL mapping for adult plant resistance to wheat stripe rust in M96-5 × Guixie 3 wheat population - Bin Cheng; Xu Gao; Ning Cao; Yanqing Ding; Tianqing Chen; Qiang Zhou; Yu Gao; Zhihai Xin; Liyi Zhang (Journal of Applied Genetics, 2022)
Development of cultivars with multiple resistances has proven to be an effective way to prevent diseases in wheat breeding. The Guixie 3 variety (GX3) has shown excellent performance in resistance to stripe rust in field for many years. The purpose of this study was to detect quantitative trait loci (QTL) associated with resistance to stripe rust in the adult plant stage and determine closely linked molecular markers. A population of recombinant inbred lines ( n = 228) was derived from a cross between the susceptible landrace Mian 96–5 (M96-5) and GX3 variety and evaluated in multiple field studies, and QTL analysis enabled to elucidate genetic architecture of wheat resistance to stripe rust. A total of 19 QTL for stripe rust resistance were mapped on 12 chromosomes using phenotypic data from multiple field tests over the course of 6 years. These chromosomes included 1B (2), 1D (2), 2A (2), 2B (2), 2D (1), 4B (2), 4D (1), 5A (3), 5B (1), 6A (1), 6B (1), and 7B (1). Two stable QTL on chromosomes 2AS ( Qyr.gaas.2A ) and 6AL ( Qyr.gaas.6A ) were detected in six and five different environments, respectively; in both QTL, positive allele was contributed by GX3 variety. Qyr.gaas.2A was found to be crucial for increasing adult plant resistance, which may explain the large phenotypic variation of 45.52%. Our results provide theoretical and molecular insight for wheat breeding and suggest the cloning of genes associated with the GX3 variety may be beneficial in future studies.

Bioeconomic evaluation of Eleutheronema tetradactylum farming: a case study in Taiwan - Cheng-Ting Huang; Farok Afero; Fang-Yu Lu; Bo-Ying Chen; Po-Lin Huang; Hsun-Yu Lan; Yen-Lung Hou (Fisheries Science, 2022)

Status and changes of water quality in typical near-city zones of three East African Great Lakes in Tanzania - Qiushi Shen; Kurt Friese; Qun Gao; Cheng Yu; Ismael A. Kimirei; Mary A. Kishe-Machumu; Lu Zhang; Guiping Wu; Yuanbo Liu; Jiaqi Zhang; Huruma Mgana; Tallent Dadi; et al. (Environmental Science and Pollution Research, 2022)

Quantitative detection of parasitic ciliate Cryptocaryon irritans in seawater with an optimized sample processing method - Jia‐Jia Tang; Zhi‐Hong Zhong; Zhi‐Cheng Li; Qing‐Kai Guo; Shi‐Yu Li; Yi‐Xuan Guo; Biao Jiang; An‐Xing Li (Journal of Fish Diseases, 2022)
The protozoan Cryptocaryon irritans is one of the most important ectoparasites of marine fish, causing ‘white spot disease’ and mass mortality in aquaculture. To accurately predict disease outbreaks and develop prevention strategies, improved detection methods are required that are sensitive, convenient and rapid. In this study, a pair of specific primers based on the C . irritans 18S rRNA gene was developed and used in a real‐time PCR (qPCR) assay. This assay was able to detect five theronts in 1 L of natural seawater. Furthermore, a linear model was established to analyse the log of Ct value and parasite abundance in seawater (y = –2.9623x + 24.2930), and the coefficient of determination (R 2 ) value was 0.979. A lysis buffer was optimized for theront DNA extraction and used for storage sample. This method was superior to the commercial water DNA kit, and there was no significant degradation of DNA at room temperature for 24–96 hr. A dilution method was developed to manage qPCR inhibitors and used to investigate natural seawater samples in a net cage farm with diseased fish, and the findings were consistent with the actual situation. This study provides a valuable tool for assisting in the early monitoring and control of cryptocaryoniasis in aquaculture.

Alternative Splicing of the Lobster (Homarus americanus) Crustacean Hyperglycemic Hormone A and B Genes Produce 2 Protein Variants Involved in Vitellogenin Inhibition - Cheng Gui Wang; Wei Wang; Li Li Shi; Yu Chun Shen; Siuming F. Chan (Frontiers in Marine Science, 2022)
Current BLASTP search analysis results suggested that the lobster ( Homarus americanus ) HaCHH-A and HaCHH-B may be derived from two different four-exon genes. Repeated tissue expression studies have revealed much different expression patterns of these two genes from those reported in the past. With RT-PCR, rapid amplification of complementary DNA (cDNA) ends (RACE), and genomic DNA cloning, we confirmed that the HaCHH-A and HaCHH-B transcripts were derived from two different four-exon CHH genes. By an alternative splicing mechanism, each gene can produce different but larger transcript variants (i.e., sHaCHH-A and sHaCHH-B ) mainly in different non-eyestalk tissues of the females. The larger and unspliced transcripts can be detected in the hepatopancreas, gill, heart, nerve cord, brain, ovary, and thoracic ganglion of the reproductive females. The expression patterns of sHaCHH-A and sHaCHH-B in other non-eyestalk tissues suggest that these transcripts have a wide spectrum of expressions during the female reproductive cycle. An in vitro organ explant culture system was developed to investigate the reproductive function of these cDNAs. The results showed that the recombinant proteins for sHaCHH-A and sHaCHH-B inhibited the gene expression of vitellogenin, whereas the double-stranded RNA (dsRNA) for sHaCHH-A and sHaCHH-B stimulated the expression of the vitellogenin gene in vitro . The results of the study may provide insights for the development of techniques to induce gonad development without using eyestalk ablation operation. This is the first in-depth report of the characterization of two four-exon CHH genes in a crustacean.

Phenolic glycosides from Sanguisorba officinalis and their anti-inflammatory effects - Jin-feng Chen; Lu Tan; Feng Ju; Qi-xuan Kuang; Tian-long Yang; Fang Deng; Yu-cheng Gu; Li-shi Jiang; Yun Deng; Da-le Guo (Natural Product Research, 2022)

Xidaosterols A and B, two new steroids with unusual α -keto-enol functionality from the South China Sea sponge Neopetrosia chaliniformis - Bao Chen; Yu-Cheng Gu; Nicole J. de Voogd; Chang-Yun Wang; Yue-Wei Guo (Natural Product Research, 2022)

Recognition and application of offlap in endorheic basins: new insights into plateau growth - Xiangjiang Yu; Zhaojie Guo; Yan Chen; Xiang Cheng; Wei Du; Zhendong Wang (International Geology Review, 2022)

Chrysomutanin and related meroterpenoids from a DES mutant of the marine-derived fungus Penicillium chrysogenum S-3-25 - Hua Qiao; Shu-Hua Zhang; Yuan Dong; Yu Yang; Rui Xu; Bo Chen; Yi Wang; Tian-Jiao Zhu; Cheng-Bin Cui; Guo-Gang Zhang; Chang-Wei Li (Natural Product Research, 2022)

Controls of Submarine Canyons Connected to Shore during the LGM Sea-Level Rise: Examples from Taiwan - Cheng-Shing Chiang; Ho-Shing Yu (Journal of Marine Science and Engineering, 2022)
During the Last Glacial Maximum (LGM) (~20,000 years ago), the sea level was lower than that during the present day by 120 m and the heads of most submarine canyons were close or connected to the coastline or shore, with enhanced terrestrial sediment input due to direct connections with river mouths. This was followed by a relative sea-level rise of 120 m and the migration of coastlines landward. As a result, the heads of some paleo-submarine canyons were no longer near river mouths or connected to the shore. Such canyons became inactive due to the lack of terrestrial sediment input. Only 4% of the world’s submarine canyons reach the coastline and remain active today. Among 13 submarine canyons off the shore of Taiwan, we identified seven (n = 7, 54%) that remain connected to the shore and are active during the present-day highstand. The purpose of this study is to determine the key controls of canyon heads that remain connected to the shore with terrestrial sediment input during the Holocene sea-level rise. As a result of high uplift rates, narrow coastal range, steep gradients, frequent earthquakes, and typhoon development in the Taiwan mountain belt, Taiwan has the highest-yield river and sediment supply. This has led to the transportation of large volumes of sediment to the surrounding deep seas. Narrow steep shelves and large sediment volumes associated with small mountain rivers are the main controls involved in the development of shore-connected canyons on the active Taiwan margin. Shore-connected canyons are present in greater numbers in the major earthquake zone on the eastern Taiwan margin. Frequent earthquake events are another significant factor in the occurrence of shore-connected canyons in the Taiwan region.

Flavonoid components and gene expression analysis reveal flower pigmentation difference between Magnolia biondii and its variety M. biondii var. purpurascens - Ning-hang Wang; Meng-yi Dai; Gang Zheng; Peng-jie Chang; Ling-juan Xuan; Zhi-gao Liu; Ya-ling Wang; Shao-yu Cheng; Zhuo-wei Wang; Hai-long Wang; Cui-hua Gu; Chao Zhang; et al. (Trees, 2022)

Quantifying effect of tassels on near-ground maize canopy RGB images using deep learning segmentation algorithm - Mingchao Shao; Chenwei Nie; Minghan Cheng; Xun Yu; Yi Bai; Bo Ming; Hongli Song; Xiuliang Jin (Precision Agriculture, 2022)

Effects of Chemotherapy on Neuroinflammation, Neuronal Damage, Neurogenesis, and Behavioral Performance in Bone Marrow Transplantation Recipient Mice - Zhong-Yuan Yu; Man-Yu Xu; Zhi-Hao Liu; Gui-Hua Zeng; Huan Fan; Cheng-Rong Tan; Yun-Feng Tu; Xian-Le Bu; Yan-Jiang Wang (Neurotoxicity Research, 2022)

Programmed Death-1 Deficiency Aggravates Motor Dysfunction in MPTP Model of Parkinson's Disease by Inducing Microglial Activation and Neuroinflammation in Mice - Ying-Ying Cheng; Bei-Yu Chen; Gan-Lan Bian; Yin-Xiu Ding; Liang-Wei Chen (Molecular Neurobiology, 2022)

DVPred: a disease-specific prediction tool for variant pathogenicity classification for hearing loss - Fengxiao Bu; Mingjun Zhong; Qinyi Chen; Yumei Wang; Xia Zhao; Qian Zhang; Xiarong Li; Kevin T. Booth; Hela Azaiez; Yu Lu; Jing Cheng; Richard J. H. Smith; et al. (Human Genetics, 2022)

Short-term effect of ambient air pollutant change on the risk of tuberculosis outpatient visits: a time-series study in Fuyang, China - Xin-Qiang Wang; Ying-Qing Li; Cheng-Yang Hu; Kai Huang; Kun Ding; Xiao-Jing Yang; Xin Cheng; Kang-Di Zhang; Wen-Jie Yu; Jie Wang; Yong-Zhong Zhang; Zhen-tao Ding; et al. (Environmental Science and Pollution Research, 2022)

Novel bioavailability-based risk assessment of Cd in earthworms and leeches utilizing in vitro digestion/Caco-2 and MDCK cells - Tian-tian Zuo; Fei-ya Luo; Huai-zhen He; Hong-yu Jin; Lei Sun; Shu-xia Xing; Bo Li; Fei Gao; Shuang-cheng Ma; Lang-chong He (Environmental Science and Pollution Research, 2022)

3D carbon aerogel from waste corrugated cardboard as a photothermal reservoir for solar steam generation - Hanxin Huo; Yuhui Ma; Yu Cheng; Junrui Cao (Environmental Science and Pollution Research, 2022)

Polycyclic aromatic hydrocarbons (PAHs) in the upstream rivers of Taihu Lake Basin, China: spatial distribution, sources and environmental risk - Lingling Wang; Xiaoming Ren; Xiaoping Wang; Perran Ye; Fei Wang; Jiade Cheng; Yan Chen; Ang Yu; Limin Zhang; Yang Qiu (Environmental Science and Pollution Research, 2022)

Study on the effect of injection rate on the fracture initiation and extension in cement-sand slurry specimens - Shanwei Hu; Yanbin Yu; Weimin Cheng; Lei Zheng; Tong Lv (Bulletin of Engineering Geology and the Environment, 2022)

Abnormal functional connectivity of the salience network in insomnia - Yongxin Cheng; Ting Xue; Fang Dong; Yiting Hu; Mi Zhou; Xiaojian Li; Ruoyan Huang; Xiaoqi Lu; Kai Yuan; Dahua Yu (Brain Imaging and Behavior, 2022)

The significance of riparian communities in the energy flow of subtropical stream ecosystems - Yi-Chang Liao; An-Cheng Lin; Han-Ni Tsai; Yu-Ting Yen; Chyng-Shyan Tzeng; Man-Miao Yang; Hsing-Juh Lin (Aquatic Sciences, 2022)

Expansion of bilin‐based red light sensors in the subaerial desert cyanobacterium Nostoc flagelliforme - Hai‐Feng Xu; Guo‐Zheng Dai; Yu‐Jie Wang; Chao Cheng; Jin‐Long Shang; Ren‐Han Li; Ke Liu; Deqiang Duanmu; Bao‐Sheng Qiu (Environmental Microbiology, 2022)
Summary Light is the crucial environmental signal for desiccation‐tolerant cyanobacteria to activate photosynthesis and prepare for desiccation at dawn. However, the photobiological characteristics of desert cyanobacteria adaptation to one of the harshest habitats on Earth remain unresolved. In this study, we surveyed the genome of a subaerial desert cyanobacterium Nostoc flagelliforme and identified two phytochromes and seven cyanobacteriochromes (CBCRs) with one or more bilin‐binding GAF (cGMP phosphodiesterase/adenylyl cyclase/FhlA) domains. Biochemical and spectroscopic analyses of 69 purified GAF‐containing proteins from recombinant phycocyanobilin (PCB), biliverdin or phycoerythrobilin‐producing Escherichia coli indicated that nine of these proteins bind chromophores. Further investigation revealed that 11 GAFs form covalent adducts responsive to near‐UV and visible light: eight GAFs contained PCB chromophores, three GAFs contained biliverdin chromophores and one contained the PCB isomer, phycoviolobilin. Interestingly, COO91_03972 is the first‐ever reported GAF‐only CBCR capable of sensing five wavelengths of light. Bioinformatics and biochemical analyses revealed that residue P132 of COO91_03972 is essential for chromophore binding to dual‐cysteine CBCRs. Furthermore, the complement of N . flagelliforme CBCRs is enriched in red light sensors. We hypothesize that these sensors are critical for the acclimatization of N . flagelliforme to weak light environments at dawn.

Unexpected role of electron‐transfer hub in direct degradation of pollutants by exoelectrogenic bacteria - Ting‐Ting Zhu; Zhou‐Hua Cheng; Sheng‐Song Yu; Wen‐Wei Li; Dong‐Feng Liu; Han‐Qing Yu (Environmental Microbiology, 2022)
Summary Exoelectrogenic bacteria (EEB) are capable of anaerobic respiration with diverse extracellular electron acceptors including insoluble minerals, electrodes and flavins, but the detailed electron transfer pathways and reaction mechanisms remain elusive. Here, we discover that CymA, which is usually considered to solely serve as an inner‐membrane electron transfer hub in Shewanella oneidensis MR‐1 (a model EEB), might also function as a reductase for direct reducing diverse nitroaromatic compounds (e.g. 2,4‐dichloronitrobenzene) and azo dyes. Such a process can be accelerated by dosing anthraquinone‐2,6‐disulfonate. The CymA‐based reduction pathways in S . oneidensis MR‐1 for different contaminants could be functionally reconstructed and strengthened in Escherichia coli . The direct reduction of lowly polar contaminants by quinol oxidases like CymA homologues might be universal in diverse microbes. This work offers new insights into the pollutant reduction mechanisms of EEB and unveils a new function of CymA to act as a terminal reductase.

Effects of Antrodia camphorata-Supplemented Diets on the Non-Specific Immune Responses and Disease Resistance of Orange-Spotted Grouper (Epinephelus coioides) against Vibrio alginolyticus and Streptococcus iniae - Hsiang-Chieh Chuang; Yin-Ze Shi; Chiu-Min Cheng; Chieh-Yu Pan; Ann-Chang Cheng (Journal of Marine Science and Engineering, 2022)
In Taiwan, the mushroom Antrodia camphorata (AC) is used for medicinal purposes, including cancer prevention and treatment. This study aimed to investigate the effect of AC-supplemented diets on the innate immunity and disease resistance of the orange-spotted grouper Epinephelus coioides against two bacterial infections—Vibrio alginolyticus and Streptococcus iniae. Orange-spotted groupers were fed AC-supplemented diets at 0 (control), 1.5, 3.0, 4.5, and 6.0 g kg−1 for 28 days and examined for innate immune responses and survival rates against V. alginolyticus and S. iniae. The results showed that the innate cellular and humoral immune parameters, including respiratory burst, phagocytic activity, and lysozyme activity of leukocytes, along with serum alternative complement activity (ACH50) and superoxide dismutase activity, as well as interleukin (IL)-4 and IL-6, were all significantly increased in groupers fed AC-supplemented diets. Groupers fed diets containing AC at doses higher than 3.0 g kg−1 had better survival rates than the control group 3–18 days after V. alginolyticus or S. iniae challenge. The enhanced disease resistance may be attributable to AC-induced innate immunity, suggesting that utilizing AC as a dietary supplement at 3.0 g kg−1 may enhance the disease resistance of orange-spotted groupers against Vibrio or Streptococcus infection.

Synergistic interactions of plant essential oils with antimicrobial agents: a new antimicrobial therapy - Jian Ju; Yunfei Xie; Hang Yu; Yahui Guo; Yuliang Cheng; He Qian; Weirong Yao (Critical Reviews in Food Science and Nutrition, 2022)

Underwater Image Restoration via DCP and Yin–Yang Pair Optimization - Kun Yu; Yufeng Cheng; Longfei Li; Kaihua Zhang; Yanlei Liu; Yufang Liu (Journal of Marine Science and Engineering, 2022)
Underwater image restoration is a challenging problem because light is attenuated by absorption and scattering in water, which can degrade the underwater image. To restore the underwater image and improve its contrast and color saturation, a novel algorithm based on the underwater dark channel prior is proposed in this paper. First of all, in order to reconstruct the transmission maps of the underwater image, the transmission maps of the blue and green channels are optimized by the proposed first-order and second-order total variational regularization. Then, an adaptive model is proposed to improve the first-order and second-order total variation. Finally, to solve the problem of the excessive attenuation of the red channel, the transmission map of the red channel is compensated by Yin–Yang pair optimization. The simulation results show that the proposed restored algorithm outperforms other approaches in terms of the visual effects, average gradient, spatial frequency, percentage of saturated pixels, underwater color image quality evaluation and evaluation metric.

MeSPL9 attenuates drought resistance by regulating JA signaling and protectant metabolite contents in cassava - Shuxia Li; Zhihao Cheng; Zhibo Li; Shiman Dong; Xiaoling Yu; Pingjuan Zhao; Wenbin Liao; Xiang Yu; Ming Peng (Theoretical and Applied Genetics, 2022)

Extensive sequence divergence between the reference genomes of Taraxacum kok-saghyz and Taraxacum mongolicum - Tao Lin; Xia Xu; Huilong Du; Xiuli Fan; Qingwen Chen; Chunyan Hai; Zijian Zhou; Xiao Su; Liquan Kou; Qiang Gao; Lingwei Deng; Jinsheng Jiang; et al. (Science China Life Sciences, 2022)

Safety and Pharmacokinetics of Intranasally Administered Heparin - Hannah M. Harris; Katherine L. Boyet; Hao Liu; Rohini Dwivedi; Nicole M. Ashpole; Ritesh Tandon; Gene L. Bidwell; Zhi Cheng; Lauren A. Fassero; Christian S. Yu; Vitor H. Pomin; Dipanwita Mitra; et al. (Pharmaceutical Research, 2022)

Polysaccharide Krestin Prevents Alzheimer’s Disease-type Pathology and Cognitive Deficits by Enhancing Monocyte Amyloid-β Processing - Si-Han Chen; Chen-Yang He; Ying-Ying Shen; Gui-Hua Zeng; Ding-Yuan Tian; Yuan Cheng; Man-Yu Xu; Dong-Yu Fan; Cheng-Rong Tan; An-Yu Shi; Xian-Le Bu; Yan-Jiang Wang (Neuroscience Bulletin, 2022)

Assessment of potential sediment disasters and resilience management of mountain roads using environmental indicators - Chao-Yuan Lin; Yuan-Chung Lai; Shao-Wei Wu; Fan-Chung Mo; Cheng-Yu Lin (Natural Hazards, 2022)
In recent years, extreme rainfall events occur frequently, causing serious watershed sediment disasters, destroying mountain roads, and endangering the safety of residents' lives and property. This study aims to deal with the spatial change of potential sediment movement on the road slope pre-disaster and to screen disaster hot spots for early warning and control system. The conceptual model is used to simulate the distribution of primary and/or derived disasters on a watershed scale to assess the impact of sediment disasters caused by heavy rain event. Correlation analysis shows that the models in assessment of primary disaster and derived disaster are significantly correlated with the collapse ratio and disaster ratio, respectively. Since the primary disaster has been considered when calculating the derived disaster risk, the terrain subdivision along Provincial Highway 21 (Tai-21) is extracted to understand the derived sediment disaster on the road slope. The model can effectively evaluate the road sections prone to disasters. According to the risk level, the hot spot of road slope disasters and the management of disaster resilience are determined and can be the reference for disaster prevention and control.

Hippocampal SIRT1-Mediated Synaptic Plasticity and Glutamatergic Neuronal Excitability Are Involved in Prolonged Cognitive Dysfunction of Neonatal Rats Exposed to Propofol - Lin-Hui Ma; Jie Wan; Jing Yan; Ning Wang; Yan-Ping Liu; Hai-Bi Wang; Cheng-Hua Zhou; Yu-Qing Wu (Molecular Neurobiology, 2022)

Study on adsorption-degradation of 2,4-dichlorophenol by modified biochar immobilized laccase - Z. Wang; D. Ren; J. Wu; S. Jiang; H. Yu; Y. Cheng; S. Zhang; X. Zhang (International Journal of Environmental Science and Technology, 2022)

Association between maternal exposure to PM10 and risk of anorectal atresia/stenosis in offspring: a population-based case-control study in Liaoning Province, China - Tie-Ning Zhang; Qi-Jun Wu; Yan-Hong Huang; Jing Li; Zong-Jiao Chen; Li-Li Li; Yan-Ling Chen; Shu Liu; Cheng-Zhi Jiang; Yu-Hong Zhao (Environmental Science and Pollution Research, 2022)

Preparation and evaluation of humic acid–based composite dust suppressant for coal storage and transportation - Xiaoxiao Yu; Xiangming Hu; Weimin Cheng; Yanyun Zhao; Zhiang Shao; Di Xue; Mingyue Wu (Environmental Science and Pollution Research, 2022)

Migration and abiotic transformation of estrone (E1) and estrone-3-sulfate (E1-3S) during soil column transport - Banghao Du; Weiwei Yu; Lun Yang; Gongduan Fan; Shuo Yang; Hui Jiang; Shenglan Bi; Cheng Yu (Environmental Geochemistry and Health, 2022)

Haloterrigena gelatinilytica sp. nov., a new extremely halophilic archaeon isolated from salt-lake - Bing-Bing Liu; Nimaichand Salam; Manik Prabhu Narsing Rao; Shuang Cheng; Yuan-Guo Xie; Lai-You Wang; Yuan-ru Zhang; Xin-Yuan Yu; Shu-xian Guo; Wen-Jun Li (Archives of Microbiology, 2022)

Another Record: Ocean Warming Continues through 2021 despite La Niña Conditions - Lijing Cheng; John Abraham; Kevin E. Trenberth; John Fasullo; Tim Boyer; Michael E. Mann; Jiang Zhu; Fan Wang; Ricardo Locarnini; Yuanlong Li; Bin Zhang; Zhetao Tan; et al. (Advances in Atmospheric Sciences, 2022)
The increased concentration of greenhouse gases in the atmosphere from human activities traps heat within the climate system and increases ocean heat content (OHC). Here, we provide the first analysis of recent OHC changes through 2021 from two international groups. The world ocean, in 2021, was the hottest ever recorded by humans, and the 2021 annual OHC value is even higher than last year’s record value by 14 ± 11 ZJ (1 zetta J = 10 21 J) using the IAP/CAS dataset and by 16 ± 10 ZJ using NCEI/NOAA dataset. The long-term ocean warming is larger in the Atlantic and Southern Oceans than in other regions and is mainly attributed, via climate model simulations, to an increase in anthropogenic greenhouse gas concentrations. The year-to-year variation of OHC is primarily tied to the El Niño-Southern Oscillation (ENSO). In the seven maritime domains of the Indian, Tropical Atlantic, North Atlantic, Northwest Pacific, North Pacific, Southern oceans, and the Mediterranean Sea, robust warming is observed but with distinct inter-annual to decadal variability. Four out of seven domains showed record-high heat content in 2021. The anomalous global and regional ocean warming established in this study should be incorporated into climate risk assessments, adaptation, and mitigation.

Comparison of nominal and standardized catch per unit effort data in quantifying habitat suitability of skipjack tuna in the equatorial Pacific Ocean - Cheng Zhou; Yuanyuan Hu; Jie Cao; Liuxiong Xu; Xuefang Wang; Rong Wan; Yu Xiao; Jiangfeng Zhu; Hao Tang (Acta Oceanologica Sinica, 2022)

MoOpy2 is essential for fungal development, pathogenicity, and autophagy in Magnaporthe oryzae - Ying‐Ying Cai; Jing‐Yi Wang; Xi‐Yu Wu; Shuang Liang; Xue‐Ming Zhu; Lin Li; Jian‐Ping Lu; Xiao‐Hong Liu; Fu‐Cheng Lin (Environmental Microbiology, 2022)
Summary The development and pathogenicity of the fungus Magnaporthe oryzae , the causal agent of destructive rice blast disease, require it to perceive external environmental signals. Opy2, an overproduction‐induced pheromone‐resistant protein 2, is a crucial protein for sensing external signals in Saccharomyces cerevisiae . However, the biological functions of the homologue of Opy2 in M. oryzae are unclear. In this study, we identified that MoOPY2 is involved in fungal development, pathogenicity, and autophagy in M. oryzae . Deletion of MoOPY2 resulted in pleiotropic defects in hyphal growth, conidiation, germ tube extension, appressorium formation, appressorium turgor generation, and invasive growth, therefore leading to attenuated pathogenicity. Furthermore, MoOpy2 participates in the Osm1 MAPK pathway and the Mps1 MAPK pathway by interacting with the adaptor protein Mst50. The interaction sites of Mst50 and MoOpy2 colocalized with the autophagic marker protein MoAtg8 in the preautophagosomal structure sites (PAS). Notably, the Δ Moopy2 mutant caused cumulative MoAtg8 lipidation and rapid GFP‐MoAtg8 degradation in response to nitrogen starvation, showing that MoOpy2 is involved in the negative regulation of autophagy activity. Taken together, our study revealed that MoOpy2 of M. oryzae plays an essential role in the orchestration of fungal development, appressorium penetration, autophagy and pathogenesis.

Endosomal sorting complexes required for transport‐0 ( ESCRT ‐0) are essential for fungal development, pathogenicity, autophagy and ER ‐phagy in Magnaporthe oryzae - Li‐Xiao Sun; Hui Qian; Meng‐Yu Liu; Ming‐Hua Wu; Yun‐Yun Wei; Xue‐Ming Zhu; Jian‐Ping Lu; Fu‐Cheng Lin; Xiao‐Hong Liu (Environmental Microbiology, 2022)
Summary Magnaporthe oryzae is an important plant pathogen that causes rice blast. Hse1 and Vps27 are components of ESCRT‐0 involved in the multivesicular body (MVB) sorting pathway and biogenesis. To date, the biological functions of ESCRT‐0 in M. oryzae have not been determined. In this study, we identified and characterized Hse1 and Vps27 in M. oryzae . Disruption of MoHse1 and MoVps27 caused pleiotropic defects in growth, conidiation, sexual development and pathogenicity, thereby resulting in loss of virulence in rice and barley leaves. Disruption of MoHse1 and MoVps27 triggered increased lipidation of MoAtg8 and degradation of GFP‐MoAtg8, indicating that ESCRT‐0 is involved in the regulation of autophagy. ESCRT‐0 was determined to interact with coat protein complex II (COPII), a regulator functioning in homeostasis of the endoplasmic reticulum (ER homeostasis), and disruption of MoHse1 and MoVps27 also blocked activation of the unfolded protein response (UPR) and autophagy of the endoplasmic reticulum (ER‐phagy). Overall, our results indicate that ESCRT‐0 plays critical roles in regulating fungal development, virulence, autophagy and ER‐phagy in M. oryzae .

Prevalence, complete genome, and metabolic potentials of a phylogenetically novel cyanobacterial symbiont in the coral‐killing sponge, Terpios hoshinota - Yu‐Hsiang Chen; Hsing‐Ju Chen; Cheng‐Yu Yang; Jia‐Ho Shiu; Daphne Z. Hoh; Pei‐Wen Chiang; Wenhua Savanna Chow; Chaolun Allen Chen; Tin‐Han Shih; Szu‐Hsien Lin; Chi‐Ming Yang; James Davis Reimer; et al. (Environmental Microbiology, 2022)
Summary Terpios hoshinota is an aggressive, space‐competing sponge that kills various stony corals. Outbreaks of this species have led to intense damage to coral reefs in many locations. Here, the first large‐scale 16S rRNA gene survey across three oceans revealed that bacteria related to the taxa Prochloron , Endozoicomonas , SAR116, Ruegeria , and unclassified Proteobacteria were prevalent in T . hoshinota . A Prochloron ‐related bacterium was the most dominant and prevalent cyanobacterium in T . hoshinota . The complete genome of this uncultivated cyanobacterium and pigment analysis demonstrated that it has phycobiliproteins and lacks chlorophyll b , which is inconsistent with the definition of Prochloron . Furthermore, the cyanobacterium was phylogenetically distinct from Prochloron , strongly suggesting that it should be a sister taxon to Prochloron . Therefore, we proposed this symbiotic cyanobacterium as a novel species under the new genus Candidatus Paraprochloron terpiosi. Comparative genomic analyses revealed that ‘Paraprochloron’ and Prochloron exhibit distinct genomic features and DNA replication machinery. We also characterized the metabolic potentials of ‘Paraprochloron terpiosi’ in carbon and nitrogen cycling and propose a model for interactions between it and T. hoshinota . This study builds a foundation for the study of the T . hoshinota microbiome and paves the way for better understanding of ecosystems involving this coral‐killing sponge.

Phylogeography and Genetic Structure of the Swimming Crabs Portunus sanguinolentus (Herbst, 1783) in East Asia - Yu-Ming Lu; Chun-Han Shih; Po-Cheng Chen; Wei-Chieh Kao; Ying-Chou Lee; Yu-San Han; Tzong-Der Tzeng (Journal of Marine Science and Engineering, 2022)
The three-spot swimming crab (Portunus sanguinolentus) is mainly distributed in South East Asia. An analysis of mitochondrial control region partial sequences allows us to determine the population genetic structure, phylogeography and historical demography of this species in East Asia. The seven populations, which included 110 individuals, were collected from mainland China (Shanghai, SH, Xiamen, XM and Hong Kong, HK), Taiwan (Yilan, YL, Taichung, TC, Donggang, DG) and Singapore (Singapore, SGP). The nucleotide diversity (π) of all individuals was 0.01149, with values ranging from 0.00372 (SGP) to 0.01345 (YL). In total, 90 haplotypes have been identified, which can be divided into two major lineages: lineage A consists of specimens from SH, YL, XM, TC and DG, and lineage B corresponds to specimen from SGP. From the second to the most recent interglacial period, population expansion was observed in each lineage. However, a low level of genetic differentiation was also observed in the three-spotted swimming crab, P. sanguinolentus, according to FST values. Our results suggest that several past and present habitat configurations have shaped the genetic patterns of P. sanguinolentus until now. During Pleistocene glaciations, when sea levels were low, this species may have moved along the coast from Southeast Asia to China. It first colonized the Hong Kong area during this era. After sea levels rose and shorelines receded, it subsequently spread to the coast of mainland China.

Downregulated Calcium-Binding Protein S100A16 and HSP27 in Placenta-Derived Multipotent Cells Induce Functional Astrocyte Differentiation - Yu-Che Cheng; Chi-Jung Huang; Wei-Chi Ku; Shu-Lin Guo; Lu-Tai Tien; Yih-Jing Lee; Chih-Cheng Chien (Stem Cell Reviews and Reports, 2022)
Little is known about genes that induce stem cells differentiation into astrocytes. We previously described that heat shock protein 27 (HSP27) downregulation is directly related to neural differentiation under chemical induction in placenta-derived multipotent stem cells (PDMCs). Using this neural differentiation cell model, we cross-compared transcriptomic and proteomic data and selected 26 candidate genes with the same expression trends in both omics analyses. Those genes were further compared with a transcriptomic database derived from Alzheimer’s disease (AD). Eighteen out of 26 candidates showed opposite expression trends between our data and the AD database. The mRNA and protein expression levels of those candidates showed downregulation of HSP27, S100 calcium-binding protein A16 (S100A16) and two other genes in our neural differentiation cell model. Silencing these four genes with various combinations showed that co-silencing HSP27 and S100A16 has stronger effects than other combinations for astrocyte differentiation. The induced astrocyte showed typical astrocytic star-shape and developed with ramified, stringy and filamentous processes as well as differentiated endfoot structures. Also, some of them connected with each other and formed continuous network. Immunofluorescence quantification of various neural markers indicated that HSP27 and S100A16 downregulation mainly drive PDMCs differentiation into astrocytes. Immunofluorescence and confocal microscopic images showed the classical star-like shape morphology and co-expression of crucial astrocyte markers in induced astrocytes, while electrophysiology and Ca 2+ influx examination further confirmed their functional characteristics. In conclusion, co-silencing of S100A16 and HSP27 without chemical induction leads to PDMCs differentiation into functional astrocytes. Graphical abstract

Damage and Failure of Hot Dry Rock under Cyclic Liquid Nitrogen Cold Shock Treatment: A Non-destructive Ultrasonic Test Method - Yong Sun; Cheng Zhai; Jizhao Xu; Xu Yu; Yuzhou Cong; Yangfeng Zheng; Wei Tang; Yujie Li (Natural Resources Research, 2022)

Lentinan triggers oxidative stress-mediated anti-inflammatory responses in lung cancer cells - Mo Li; Xin Du; Zheng Yuan; Mengzhi Cheng; Penghua Dong; Yu Bai (Molecular and Cellular Biochemistry, 2022)

Structure modification, antialgal, antiplasmodial, and toxic evaluations of a series of new marine-derived 14-membered resorcylic acid lactone derivatives - Wei-Feng Xu; Na-Na Wu; Yan-Wei Wu; Yue-Xuan Qi; Mei-Yan Wei; Laura M. Pineda; Michelle G. Ng; Carmenza Spadafora; Ji-Yong Zheng; Ling Lu; Chang-Yun Wang; Yu-Cheng Gu; et al. (Marine Life Science & Technology, 2022)
Marine natural products play critical roles in the chemical defense of many marine organisms and are essential, reputable sources of successful drug leads. Sixty-seven 14-membered resorcylic acid lactone derivatives 3 – 27 and 30 – 71 of the natural product zeaenol ( 1 ) isolated from the marine-derived fungus Cochliobolus lunatus were semisynthesized by chlorination, acylation, esterification, and acetalization in one to three steps. The structures of these new derivatives were established by HRESIMS and NMR techniques. All the compounds ( 1 – 71 ) were evaluated for their antialgal and antiplasmodial activities. Among them, 14 compounds displayed antifouling activities against adhesion of the fouling diatoms. In particular, 9 and 34 exhibited strong and selective inhibitory effects against the diatoms Navicula laevissima and Navicula exigua (EC 50 = 6.67 and 8.55 μmol/L), respectively, which were similar in efficacy to those of the positive control SeaNine 211 (EC 50 = 2.90 and 9.74 μmol/L). More importantly, 38 , 39 , and 69 – 71 showed potent antiplasmodial activities against Plasmodium falciparum with IC 50 values ranging from 3.54 to 9.72 μmol/L. Very interestingly, the five antiplasmodial derivatives displayed non-toxicity in the cytotoxicity assays and the zebrafish embryos model, thus, representing potential promising antiplasmodial drug agents. The preliminary structure–activity relationships indicated that biphenyl substituent at C-2, acetonide at positions C-5′ and C-6′, and tri- or tetra-substituted of acyl groups increased the antiplasmodial activity. Therefore, combining evaluation of chemical ecology with pharmacological models will be implemented as a systematic strategy, not only for environmentally friendly antifoulants but also for structurally novel drugs.

First report of a crinivirus infecting mulberry (Morus alba L.) in China - Peng Zhang; Yu Ma; Tao-Tao Han; William Kojo Smith; Jing Yu; Yong-Yuan Cheng; Quan-You Lu (Journal of Plant Pathology, 2022)

Spatial heterogeneity of changes in cropland ecosystem water use efficiency and responses to drought in China - Anzhou Zhao; Qiuyan Yu; Dayu Cheng; Anbing Zhang (Environmental Science and Pollution Research, 2022)

Organic carbon and acidic ions in PM2.5 contributed to particle bioreactivity in Chinese megacities during haze episodes - Kin-Fai Ho; Ya-Chun Lee; Xinyi Niu; Hongmei Xu; Renjian Zhang; Jun-Ji Cao; Cheng-Yu Tsai; Ta-Chih Hsiao; Hsiao-Chi Chuang (Environmental Science and Pollution Research, 2022)

Comparative Genomic Analysis of Streptococcus pneumoniae Strains: Penicillin Non-susceptible Multi-drug-Resistant Serotype 19A Isolates - Lifeng Li; Juanjuan Zhou; Mingchao Li; Zengyuan Yu; Kaijie Gao; Junwen Yang; Ping Cheng; Junmei Yang; Wancun Zhang; Zhidan Yu; Huiqing Sun (Current Microbiology, 2022)

Exploring tourism networks in the Guangxi mountainous area using mobility data from user generated content - Yan-hua Liu; Jian-quan Cheng; Yu-lan Lyu (Journal of Mountain Science, 2022)

Spatio-temporal characteristics of population and economy in transitional geographic space at the southern end of “Hu Huan-yong Line” - Wei Deng; Yu-fang Cheng; Huan Yu; Li Peng; Bo Kong; Yu-ting Hou (Journal of Mountain Science, 2022)

Optical Flow Analysis of Left Ventricle Wall Motion with Real-Time Cardiac Magnetic Resonance Imaging in Healthy Subjects and Heart Failure Patients - Yu Y. Li; Jason Craft; Yang Cheng; William Schapiro; Kathleen Gliganic; Elizabeth Haag; J. Jane Cao (Annals of Biomedical Engineering, 2022)

Pre-inoculation with Bradyrhizobium japonicum confers NaCl tolerance by improving nitrogen status and ion homeostasis in wild soybean (Glycine soja L.) seedlings - Ying Wang; Cong Cheng; Ziyi Du; Bingjun Yu (Acta Physiologiae Plantarum, 2022)

A new N -containing phenolic glycoside from Capsicum annuum L. - Changwei Song; Changyan Yu; Xinting Zhu; Xirong Luo; Yong Zhang; Lingjie Meng; Yong Luo; Han Chang; Cheng Qin; Yun Liu (Natural Product Research, 2022)

Environmental Filtering by pH and Salinity Jointly Drives Prokaryotic Community Assembly in Coastal Wetland Sediments - Huang Yu; Qiuping Zhong; Yisheng Peng; Xiafei Zheng; Fanshu Xiao; Bo Wu; Xiaoli Yu; Zhiwen Luo; Longfei Shu; Cheng Wang; Qingyun Yan; Zhili He (Frontiers in Marine Science, 2022)
Understanding the microbial community assembly is an essential topic in microbial ecology. Coastal wetlands are an important blue carbon sink, where microbes play a key role in biogeochemical cycling of nutrients and energy transformation. However, the drivers controlling the distribution patterns and assembly of bacterial and archaeal communities in coastal wetland are unclear. Here we examined the diversity, co-occurrence network, assembly processes and environmental drivers of bacterial and archaeal communities from inshore to offshore sediments by the sequencing of 16S rRNA gene amplicons. The value of α- and β-diversity of bacterial and archaeal communities generally did not change significantly ( P > 0.05) between offshore sites, but changed significantly ( P < 0.05) among inshore sites. Sediment pH and salinity showed significant effects on the diversity and keystone taxa of bacterial and archaeal communities. The bacterial and archaeal co-occurrence networks were inextricably linked with pH and salinity to formed the large network nodes, suggesting that they were the key factors to drive the prokaryotic community. We also identified that heterogeneous and homogeneous selection drove the bacterial and archaeal community assembly, while the two selections became weaker from offshore sites to inshore sites, suggesting that deterministic processes were more important in offshore sites. Overall, these results suggested that the environmental filtering of pH and salinity jointly governed the assembly of prokaryotic community in offshore sediments. This study advances our understanding of microbial community assembly in coastal wetland ecosystems.

Distribution of Coomassie Blue Stainable Particles in the Pearl River Estuary, China, Insight Into the Nitrogen Cycling in Estuarine System - Cui-Ci Sun; Wei-Zhong Yue; You-Shao Wang; Wei-Hong He; Yi-Guo Hong; Fu-Lin Sun; Hao Cheng; Mei-Lin Wu; Zhao-Yu Jiang; Fei Jiao; Yu-Tu Wang (Frontiers in Marine Science, 2022)
Distributions of Coomassie Blue stainable particles (CSP), the sources and transports, as well as their implications for nitrogen biogeochemical cycles in the Pearl River estuary (PRE) were investigated during two cruises in August 2016 and January 2017. CSP color concentrations (CSP concentration determined spectrophotometrically) were 73.7–685.3 μg BSA eq L –1 [μg Bovine serum albumin (BSA) equivalent liter –1 ] in August 2016 and 100.6–396.4 μg BSA eq L –1 in January 2017, respectively. CSP concentrations were high in low-salinity waters (<5), and declined from the river to the middle estuary by 80% in the wet season and 55.6% in the dry season, respectively, then increased again in the lower estuary due to high primary production. CSP concentrations were mainly associated with chlorophyll a (Chl a ) concentration except for the turbid mixing zone, suggesting that autochthonous phytoplankton production served as the primary source of CSP in the PRE. The concentrations of nitrogen (N) as CSP in the PRE were comparable to the nitrogen content of particulate hydrolysable amino acids (PHAA). Pictures of CSP taken by microscopy and the correlation between composition of PHAA and the ratio of Chl a /CSP color showed that CSP were relatively degraded due to delivery of old terrestrial protein to river section and extensive microbial degradation during mixing at the upper and middle parts of the estuary, whereas CSP in lower estuary appeared to be more labile due to higher fresh algal production. The contribution of CSP nitrogen (CSP-N) to the particulate nitrogen (PN) pool was 34.98% in summer and 30.8% in winter. The conservative estimate of CSP-N input flux in the Pearl River Delta was about 6 × 10 6 mol N d –1 . These results suggested that CSP was a significant pool of organic nitrogen in the PRE. The study of CSP composition in terms of nitrogen provides new insight into the roles of CSP on nitrogen biogeochemical processes in the turbid and productive estuarine system.

Genome-wide identification and expression analysis of GL2-interacting-repressor (GIR) genes during cotton fiber and fuzz development - Xiaoxu Feng; Hailiang Cheng; Dongyun Zuo; Youping Zhang; Qiaolian Wang; Limin Lv; Shuyan Li; John Z. Yu; Guoli Song (Planta, 2022)

Association of Increased Amygdala Activity with Stress-Induced Anxiety but not Social Avoidance Behavior in Mice - Shou-He Huang; Wei-Zhu Liu; Xia Qin; Chen-Yi Guo; Qing-Cheng Xiong; Yu Wang; Ping Hu; Bing-Xing Pan; Wen-Hua Zhang (Neuroscience Bulletin, 2022)

Metabolite transporters as regulators of macrophage polarization - Jingwen Cheng; Weiwei Cai; Shiye Zong; Yun Yu; Fang Wei (Naunyn-Schmiedeberg's Archives of Pharmacology, 2022)

Flood vulnerability assessment using the triangular fuzzy number-based analytic hierarchy process and support vector machine model for the Belt and Road region - Yu Duan; Junnan Xiong; Weiming Cheng; Nan Wang; Yi Li; Yufeng He; Jun Liu; Wen He; Gang Yang (Natural Hazards, 2022)

Development of a one-plasmid system to replace the endogenous protein with point mutation for post-translational modification studies - Iqra Ishrat; Aoxing Cheng; Fazhi Yu; Jing Guo; Peng Zhang; Kaiguang Zhang; Zhenye Yang (Molecular Biology Reports, 2022)

Two new species of Ceriporia (Irpicaceae, Basidiomycota) from the Asia Pacific area - Jia-Jia Chen; Ya-Rong Wang; Chao-Ge Wang; Yu-Cheng Dai (Mycological Progress, 2022)

The phenolic acids from Oplopanax elatus Nakai stems and their potential photo-damage prevention activity - Yu Han; Dongsheng Cheng; Mimi Hao; Jiejing Yan; Jingya Ruan; Lifeng Han; Yi Zhang; Tao Wang (Journal of Natural Medicines, 2022)

YAP regulates porcine skin-derived stem cells self-renewal partly by repressing Wnt/β-catenin signaling pathway - Hong-Chen Yan; Yu Sun; Ming-Yu Zhang; Shu-Er Zhang; Jia-Dong Sun; Paul W. Dyce; Francesca Gioia Klinger; Massimo De Felici; Wei Shen; Shun-Feng Cheng (Histochemistry and Cell Biology, 2022)

Associations between lung-deposited dose of particulate matter and culture-positive pulmonary tuberculosis pleurisy - Kuan-Jen Bai; Nguyen Thanh Tung; Ta-Chih Hsiao; Tsai-Ling Chen; Kian Fan Chung; Shu-Chuan Ho; Cheng-Yu Tsai; Jen-Kun Chen; Chun-Nin Lee; Kang-Yun Lee; Chih-Cheng Chang; Tzu-Tao Chen; et al. (Environmental Science and Pollution Research, 2022)

Promotional effect of ZrO2 and WO3 on bimetallic Pt-Pd diesel oxidation catalyst - Rongrong Fan; Zhaoqiang Li; Yu Wang; Yan Wang; Zhiyong Ding; Cheng Zhang; Na Kang; Xin Guo; Rong Wang (Environmental Science and Pollution Research, 2022)

Enhancing denitrification in constructed wetland with algae addition - Shuiping Cheng; Jing Huai; Fei Zhong; Juan Wu; Shaole Yu (Environmental Science and Pollution Research, 2022)

Experimental and numerical investigations of a catastrophic tailings dam break in Daye, Hubei, China - Yu Zhuang; Kaiping Jin; Qiangong Cheng; Aiguo Xing; Hao Luo (Bulletin of Engineering Geology and the Environment, 2022)

Infestation and distribution of mites on the Yunnan red-backed vole (Eothenomys miletus) in Yunnan Province of southwest China between 2001 and 2015 - Rong Xiang; Xian-Guo Guo; Tian-Guang Ren; Cheng-Fu Zhao; Rong Fan; Zhi-Wei Zhang; Ke-Yu Mao; Pei-Ying Peng; Xiao-Bin Huang; Ti-Jun Qian (Biologia, 2022)

A novel alphahypovirus that infects the fungal plant pathogen Sclerotinia sclerotiorum - Weibo Liang; Zhongbo Lu; Jie Duan; Daohong Jiang; Jiatao Xie; Jiasen Cheng; Yanping Fu; Tao Chen; Bo Li; Xiao Yu; Weidong Chen; Yang Lin (Archives of Virology, 2022)

Characterization of a strong constitutive promoter from paper mulberry vein banding virus - William K. Smith; Yu Ma; Jing Yu; Yong-Yuan Cheng; Peng Zhang; Tao-Tao Han; Quan-You Lu (Archives of Virology, 2022)

Isolation and partial characterization of a novel bacteriocin from Pseudomonas azotoformans with antimicrobial activity against Pasterella multocida - Yu Wang; Shuang Lei; Inam Muhammad; Yu Jia; Cheng-guang He; Yi-Ming Wang; Yun-Hang Gao; Ling-Cong Kong; Hong-Xia Ma (Archives of Microbiology, 2022)

Nakamurella leprariae sp. nov., isolated from a lichen sample - De-Feng An; Shao-Juan Yang; Long-Qian Jiang; Xin-Yu Wang; Xiao-Yu Huang; Lei Lang; Xue-Mei Chen; Ming-Qun Fan; Gui-Ding Li; Ming-Guo Jiang; Li-Song Wang; Cheng-Lin Jiang; et al. (Archives of Microbiology, 2022)

Not out of the woods yet: Signatures of the prolonged negative genetic consequences of a population bottleneck in a rapidly re‐expanding wader, the black‐faced spoonbill Platalea minor - Shou‐Hsien Li; Yang Liu; Chia‐Fen Yeh; Yuchen Fu; Carol K. L. Yeung; Chun‐Cheng Lee; Chi‐Cheng Chiu; Tung Hui Kuo; Fang‐Tse Chan; Yu‐Chia Chen; Wen‐Ya Ko; Cheng‐Te Yao (Molecular Ecology, 2022)
The long‐term persistence of a population which has suffered a bottleneck partly depends on how historical demographic dynamics impacted its genetic diversity and the accumulation of deleterious mutations. Here we provide genomic evidence for the genetic effect of a recent population bottleneck in the endangered black‐faced spoonbill ( Platalea minor ) after its rapid population recovery. Our data suggest that the bird's effective population size, N e , had been relatively stable (7500–9000) since 22,000 years ago; however, a recent brief yet severe bottleneck ( N e = 20) which we here estimated to occur around the 1940s wiped out >99% of its historical N e in roughly three generations. Despite a >15‐fold population recovery since 1988, we found that black‐faced spoonbill population has higher levels of inbreeding (7.4 times more runs of homozygosity) than its sister species, the royal spoonbill ( P. regia ), which is not thought to have undergone a marked population contraction. Although the two spoonbills have similar levels of genome‐wide genetic diversity, our results suggest that selection on more genes was relaxed in the black‐faced spoonbill; moreover individual black‐faced spoonbills carry more putatively deleterious mutations (Grantham's score > 50), and may therefore express more deleterious phenotypic effects than royal spoonbills. Here we demonstrate the value of using genomic indices to monitor levels of genetic erosion, inbreeding and mutation load in species with conservation concerns. To mitigate the prolonged negative genetic effect of a population bottleneck, we recommend that all possible measures should be employed to maintain population growth of a threatened species.

Cytotoxic benzopyranone and xanthone derivatives from a coral symbiotic fungus Cladosporium halotolerans GXIMD 02502 - Chao-Nan Wang; Hu-Mu Lu; Cheng-Hai Gao; Lang Guo; Zhen-Yu Zhan; Jun-Jian Wang; Yong-Hong Liu; Song-Tao Xiang; Jian Wang; Xiao-Wei Luo (Natural Product Research, 2021)

Impacts of pavement on the growth and biomass of young pine, ash and maple trees - Bowen Cui; Xuming Wang; Yuebo Su; Yuanyuan Chen; Weiwei Yu; Cheng Gong; Li Li; Abdur Rehim; Xiaoke Wang (Trees, 2021)

Fine mapping and identification of the candidate gene BFS for fruit shape in wax gourd (Benincasa hispida) - Zhikui Cheng; Zhengguo Liu; Yuanchao Xu; Lianlian Ma; Jieying Chen; Jiquan Gou; Liwen Su; Wenting Wu; Yong Chen; Wenjin Yu; Peng Wang (Theoretical and Applied Genetics, 2021)

Endocrine pheromones couple fat rationing to dauer diapause through HNF4α nuclear receptors - Cheng Gao; Qi Li; Jialei Yu; Shiwei Li; Qingpo Cui; Xiao Hu; Lifeng Chen; Shaobing O. Zhang (Science China Life Sciences, 2021)

Longitudinal virological changes and underlying pathogenesis in hospitalized COVID-19 patients in Guangzhou, China - Zhengtu Li; Yinhu Li; Ruilin Sun; Shaoqiang Li; Lingdan Chen; Yangqing Zhan; Mingzhou Xie; Jiasheng Yang; Yanqun Wang; Airu Zhu; Guoping Gu; Le Yu; et al. (Science China Life Sciences, 2021)

Neonatal Anesthesia by Ketamine in Neonatal Rats Inhibits the Proliferation and Differentiation of Hippocampal Neural Stem Cells and Decreases Neurocognitive Function in Adulthood via Inhibition of the Notch1 Signaling Pathway - He Huang; Chao Zhao; Qian Hu; Qiang Liu; Yi-Man Sun; Chen Chen; Hui Huang; Cheng-Hua Zhou; Yu-Qing Wu (Molecular Neurobiology, 2021)

Alantolactone exhibits antiproliferative and apoptosis-promoting properties in colon cancer model via activation of the MAPK-JNK/c-Jun signaling pathway - Yijing Ren; Cheng Lv; Jing Zhang; Beibei Zhang; Bei Yue; Xiaoping Luo; Zhilun Yu; Hao Wang; Junyu Ren; Zhengtao Wang; Wei Dou (Molecular and Cellular Biochemistry, 2021)

c-Abl Tyrosine Kinase-Mediated Neuronal Apoptosis in Subarachnoid Hemorrhage by Modulating the LRP-1-Dependent Akt/GSK3β Survival Pathway - Cong Yan; Hongwei Yu; Yao Liu; Pei Wu; Chunlei Wang; Hongbo Zhao; Kongbin Yang; Qi Shao; Yingqiang Zhong; Wenyang Zhao; Jingwei Li; Nan Liu; et al. (Journal of Molecular Neuroscience, 2021)

Effects of food quantity on aggression and monoamine levels of juvenile pufferfish (Takifugu rubripes) - Yu Hu; Ying Liu; Cheng Zhou; Haixia Li; Jize Fan; Zhen Ma (Fish Physiology and Biochemistry, 2021)

Does the smart city policy promote the green growth of the urban economy? Evidence from China - Yu Qian; Jun Liu; Zhonghua Cheng; Jeffrey Yi-Lin Forrest (Environmental Science and Pollution Research, 2021)

Correction to: Ocean acidification alters the thermal performance curves of brooded larvae from the reef coral Pocillopora damicornis - Lei Jiang; You-Fang Sun; Yu-Yang Zhang; Yuan Tian; Xin-Ming Lei; Guo-Wei Zhou; Tao Yuan; Xiang-Cheng Yuan; Sheng Liu; Hui Huang (Coral Reefs, 2021)

Numerical simulation study on the seepage characteristics of coal seam infusion effected by mining-induced stress - Yanbin Yu; Qilin Xin; Weimin Cheng; Jun Rui; Xin Zhang (Bulletin of Engineering Geology and the Environment, 2021)

Biological synthesis of nicotinamide mononucleotide - Qi Shen; Shi-Jia Zhang; Yu-Zhen Xue; Feng Peng; Dong-Yuan Cheng; Ya-Ping Xue; Yu-Guo Zheng (Biotechnology Letters, 2021)

Individual and combined influences of main loading parameters on granite damage development under ultrasonic vibration - Cheng Zhang; Da-jun Zhao; Shu-lei Zhang; Yu Zhou (Journal of Mountain Science, 2021)

Establishment of an immortalized cell line derived from the pupal ovary of Mythimna separata (Lepidoptera: Noctuidae) and identification of the cell source - Yan Tong; Lu-Qiang Cheng; Xuan Li; Xu-Peng Yu; Rui-Hao Shu; Ji-Hong Zhang; Qian Meng; Qi-Lian Qin; Kai Tang; Jian-Xiang Xu; Huan Zhang (Cell and Tissue Research, 2021)

A novel regQTL-SNP and the risk of lung cancer: a multi-dimensional study - Yuhui Yu; Liping Mao; Zhounan Cheng; Xiaoqi Zhu; Jiahua Cui; Xiaoyu Fu; Jingwen Cheng; Yan Zhou; Anni Qiu; Yang Dong; Xun Zhuang; Yihua Lu; et al. (Archives of Toxicology, 2021)

Investigation on the statistical characteristics of geoelectric field seismic anomalies in the North–South seismic belt of Chinese mainland - Hou Ze-Yu; An Zhang-Hui; Fan Ying-Ying; Tan Da-Cheng; Fu A-Long; Wei Lei (Acta Geophysica, 2021)

Household environmental microbiota influences early‐life eczema development - Le Duc Huy Ta; Carina Jing Xuan Tay; Christophe Lay; Paola Florez de Sessions; Cheryl Pei Ting Tan; Michelle Jia Yu Tay; Hui Xing Lau; Atiqa Binte Zulkifli; Gaik Chin Yap; Elizabeth Huiwen Tham; Eliza Xin Pei Ho; Anne Eng Neo Goh; et al. (Environmental Microbiology, 2021)
Summary Exposure to a diverse microbial environment during pregnancy and early postnatal period is important in determining predisposition towards allergy. However, the effect of environmental microbiota exposure during preconception, pregnancy and postnatal life on development of allergy in the child has not been investigated so far. In the S‐PRESTO (Singapore PREconception Study of long Term maternal and child Outcomes) cohort, we collected house dust during all three critical window periods and analysed microbial composition using 16S rRNA gene sequencing. At 6 and 18 months, the child was assessed for eczema by clinicians. In the eczema group, household environmental microbiota was characterized by presence of human‐associated bacteria Actinomyces , Anaerococcus, Finegoldia, Micrococcus, Prevotella and Propionibacterium at all time points, suggesting their possible contributions to regulating host immunity and increasing the susceptibility to eczema. In the home environment of the control group, putative protective effect of an environmental microbe Planomicrobium ( Planococcaceae family) was observed to be significantly higher than that in the eczema group. Network correlation analysis demonstrated inverse relationships between beneficial Planomicrobium and human‐associated bacteria ( Actinomyces , Anaerococcus, Finegoldia, Micrococcus, Prevotella and Propionibacterium ). Exposure to natural environmental microbiota may be beneficial to modulate shed human‐associated microbiota in an indoor environment.

Morphological Significance and Relation of Ecosystems of Submarine Canyons off SW Taiwan - Cheng-Shing Chiang; Ho-Shing Yu (Journal of Marine Science and Engineering, 2021)
There are four shelf-incising submarine canyons off SW Taiwan. They are distributed along the active continental margin, which is periodically flushed by gravity flows. Shelf-incising canyons, such as Kaoping Canyon, may not only be affected by oceanographic conditions but also by extreme climate change due to the direct input of river sediment. In the canyons along the SW margin of Taiwan, strong sedimentary flows are reflected in highly abundant nutrient input and physical disturbances. The Kaoping Canyon possesses habitats that promote biodiversity but that are sensitive to environmental change. The aims of this study are to review the canyons along the SW margin of Taiwan and to present their geomorphological features and associated ecosystems.

Dammarane-type saponins from Gynostemma pentaphyllum and their cytotoxicities - Wei-Ye Cui; Yulian Jin; Hui Liu; Ma-Li Zu; Xin-Fang Zhai; Ce Yang; Yu-Long Gu; Yong Cheng; Xiang-Lan Piao (Natural Product Research, 2021)

The chemical profile and biological activity of different extracts of Sapindus mukorossi Gaertn. against Cutibacterium acnes - Min-Ping Wei; Jin-Dan Qiu; Lu Li; Yun-Fei Xie; Ya-Hui Guo; Hang Yu; Yu-Liang Cheng; He Qian; Wei-Rong Yao (Natural Product Research, 2021)

Isolation of two sesquiterpene glycosides from Sapindus mukorossi Gaertn. with cytotoxic properties and analysis of their mechanism based on network pharmacology - Min-ping Wei; Xiao-wen Zhu; Hang Yu; Yun-fei Xie; Ya-hui Guo; Yu-liang Cheng; He Qian; Wei-rong Yao (Natural Product Research, 2021)

A Unique Diel Pattern in Carbonate Chemistry in the Seagrass Meadows of Dongsha Island: The Enhancement of Metabolic Carbonate Dissolution in a Semienclosed Lagoon - Wen-Chen Chou; Lan-Feng Fan; Chang-Chang Yang; Ying-Hsuan Chen; Chin-Chang Hung; Wei-Jen Huang; Yung-Yen Shih; Keryea Soong; Hsiao-Chun Tseng; Gwo-Ching Gong; Hung-Yu Chen; Cheng-Kuan Su (Frontiers in Marine Science, 2021)
In contrast to other seagrass meadows where seawater carbonate chemistry generally shows strong diel variations with higher pH but lower partial pressure of CO 2 ( p CO 2 ) during the daytime and lower pH but higher p CO 2 during nighttime due to the alternation in photosynthesis and respiration, the seagrass meadows of the inner lagoon (IL) on Dongsha Island had a unique diel pattern with extremely high pH and low p CO 2 across a diel cycle. We suggest that this distinct diel pattern in pH and p CO 2 could be associated with the enhancement of total alkalinity (TA) production coupled to carbonate sediment dissolution in a semienclosed lagoon. The confinement of the IL may hamper water exchange and seagrass detritus export to the adjacent open ocean, which may result in higher organic matter loading to the sediments, and longer residence time of the water in the IL, accompanied by microbial respiration (both aerobic and anaerobic) that may reduce carbonate saturation level to drive carbonate dissolution and thus TA elevation, thereby forming such a unique diel pattern in carbonate chemistry. This finding further highlights the importance of considering TA production through metabolic carbonate dissolution when evaluating the potential of coastal blue carbon ecosystems to buffer ocean acidification and to absorb atmospheric CO 2 , in particular in a semienclosed setting.

Cytotoxic triterpenoid glycosides from leaves of Cyclocarya paliurus - Hui-Hui Sun; Wen-Yan Lv; Jie Tan; Yu-Cheng Tang; Hui Zhu; Jian-Bo Qu; Jing Li; Jian-Ping Wu; Xi-Wen Chang; Zhi-Chun Yang; Wen-Xuan Wang; Zu-Hui Chen; et al. (Natural Product Research, 2021)

Two new nor-sesquiterpenoids from Fusarium tricinctum , an endophytic fungus isolated from Ligusticum chuanxiong - Yu-Mei Cao; Da-Le Guo; Meng-Ying Jin; Lu Tan; Tian-Long Yang; Fang Deng; Yu-Cheng Gu; Xiao-Hua Li; Zhi-Xing Cao; Yun Deng (Natural Product Research, 2021)

TLR2 Potentiates SR-Marco-Mediated Neuroinflammation by Interacting with the SRCR Domain - Lu Wang; Han-Yu Yang; Cai-Xia Zang; Jun-Mei Shang; Hui Liu; Zi-Hong Zhang; Fang-Yu Yuan; Cheng Ju; Fang-Yuan Li; Xiu-Qi Bao; Dan Zhang (Molecular Neurobiology, 2021)

Correction to: Fluorescence recovery after photobleaching: analyses of cyanobacterial phycobilisomes reveal intrinsic fluorescence recovery - Nan Zhang; Kang Li; Bin-Bin Xie; Xiu-Lan Chen; Bai-Cheng Zhou; Hai-Nan Su; Yu-Zhong Zhang (Marine Life Science & Technology, 2021)

Fluorescence recovery after photobleaching: analyses of cyanobacterial phycobilisomes reveal intrinsic fluorescence recovery - Nan Zhang; Kang Li; Bin-Bin Xie; Xiu-Lan Chen; Bai-Cheng Zhou; Hai-Nan Su; Yu-Zhong Zhang (Marine Life Science & Technology, 2021)

The intriguing chemistry and biology of sulfur-containing natural products from marine microorganisms (1987–2020) - Yang Hai; Mei-Yan Wei; Chang-Yun Wang; Yu-Cheng Gu; Chang-Lun Shao (Marine Life Science & Technology, 2021)
Natural products derived from marine microorganisms have received great attention as a potential resource of new compound entities for drug discovery. The unique marine environment brings us a large group of sulfur-containing natural products with abundant biological functionality including antitumor, antibiotic, anti-inflammatory and antiviral activities. We reviewed all the 484 sulfur-containing natural products (non-sulfated) isolated from marine microorganisms, of which 59.9% are thioethers, 29.8% are thiazole/thiazoline-containing compounds and 10.3% are sulfoxides, sulfones, thioesters and many others. A selection of 133 compounds was further discussed on their structure–activity relationships, mechanisms of action, biosynthesis, and druggability. This is the first systematic review on sulfur-containing natural products from marine microorganisms conducted from January 1987, when the first one was reported, to December 2020.

Effect of Palrnatine on lipopolysaccharide-induced acute lung injury by inhibiting activation of the Akt/NF-κB pathway - Xingchi Kan; Yingsheng Chen; Bingxu Huang; Shoupeng Fu; Wenjin Guo; Xin Ran; Yu Cao; Dianwen Xu; Ji Cheng; Zhanqing Yang; Yanling Xu (Journal of Zhejiang University-SCIENCE B, 2021)

Using time series InSAR to assess the deformation activity of open-pit mine dump site in severe cold area - Chuangang Gong; Shaogang Lei; Zhengfu Bian; Yu Tian; Zhouai Zhang; Haiqiao Guo; Hao Zhang; Wei Cheng (Journal of Soils and Sediments, 2021)

Human umbilical cord-derived mesenchymal stem cell-exosomal miR-627-5p ameliorates non-alcoholic fatty liver disease by repressing FTO expression - Lidan Cheng; Peng Yu; Fangfang Li; Xueling Jiang; Xiaojuan Jiao; Yunfeng Shen; Xiaoyang Lai (Human Cell, 2021)

Impact of rhizosphere microorganisms on arsenic (As) transformation and accumulation in a traditional Chinese medical plant - Jiao-Jiao Li; Long Yang; Cui-Ping Miao; Ya-Jun Teng; Zi-Hao Fu; Chang-Lei Cheng; Xue-Xiu Chang; Yu Qian; Li-Xing Zhao (Environmental Science and Pollution Research, 2021)

Evaluating the energy, health efficiency, and productivity in OECD - Ching-Cheng Lu; Yung-ho Chiu; Chih-Yu Yang; Tai-Yu Lin (Environmental Geochemistry and Health, 2021)

Bacterial community variations in the South China Sea driven by different chemical conditions - Fu-lin Sun; You-Shao Wang; Mei-Lin Wu; Cui-Ci Sun; Zhao-Yu Jiang; Hao Cheng; Jiao Fei (Ecotoxicology, 2021)

Differential metabolism-associated gene expression of duck pancreatic cells in response to two strains of duck hepatitis A virus type 1 - Zhen Chen; Shao-hua Shi; Yu Huang; Cui-qin Huang; Rong-chang Liu; Long-fei Cheng; Guang-hua Fu; Hong-mei Chen; Chun-he Wan; Qiu-ling Fu (Archives of Virology, 2021)
Several outbreaks of duck hepatitis A virus type 1 (DHAV-1), which were characterized by yellow coloration and hemorrhage in pancreatic tissues, have occurred in China. The causative agent is called pancreatitis-associated DHAV-1. The mechanisms involved in pancreatitis-associated DHAV-1 infection are still unclear. Transcriptome analysis of duck pancreas infected with classical-type DHAV-1 and pancreatitis-associated DHAV-1 was carried out. Deep sequencing with Illumina-Solexa resulted in a total of 53.9 Gb of clean data from the cDNA library of the pancreas, and a total of 29,597 unigenes with an average length of 993.43 bp were generated by de novo sequence assembly. The expression levels of D-3-phosphoglycerate dehydrogenase, phosphoserine aminotransferase, and phosphoserine phosphatase, which are involved in glycine, serine, and threonine metabolism pathways, were significantly downregulated in ducks infected with pancreatitis-associated DHAV-1 compared with those infected with classical-type DHAV-1. These findings provide information regarding differences in expression levels of metabolism-associated genes between ducks infected with pancreatitis-associated DHAV-1 and those infected with classical-type DHAV-1, indicating that intensive metabolism disorders may contribute to the different phenotypes of DHAV-1-infection.

The seepage characteristics of coal under the hydraulic-mechanics coupling conditions considering the variation of porosity - Yanbin Yu; Xin Zhang; Weimin Cheng; Xihui Yang; Lei Zheng (Arabian Journal of Geosciences, 2021)

Vertical Nitrate Flux Induced by Kelvin–Helmholtz Billows Over a Seamount in the Kuroshio - Cristy S. Acabado; Yu-Hsin Cheng; Ming-Huei Chang; Chung-Chi Chen (Frontiers in Marine Science, 2021)
Kelvin–Helmholtz (KH) billows can facilitate microscale turbulent mixing around seamounts in the Kuroshio. This study sought to describe the influence of billow intensity (i.e., “intermittent and small” and “steady and large” billows) on vertical nitrate fluxes. KH billows led to turbulent kinetic energy dissipation rates [ε = O (10 –7 to 10 –6 ) W kg –1 ] and eddy diffusivities [K ρ = O (10 –4 to 10 –3 ) m 2 s –1 ] that were significantly stronger than those outside the billow depths. The mean nitrate flux estimated using K ρ in the billow depths had a maximal value of 10.0 mmol m –2 day –1 , which was much higher than estimates for the open ocean. The nitrate flux associated with the shallow KH billows at two vertical levels contributed to enrich the subsurface phytoplankton maximum, while the deeper billows closer to the summit were found to induce a large amount of nitrate flux from the deeper to the subsurface water. This study showed that KH billows make important contributions to seamount ecosystems, particularly in the cycling and vertical mixing of nutrients to make them available for potential downstream transport.

Comparison of Primary Production Using in situ and Satellite-Derived Values at the SEATS Station in the South China Sea - Yung-Yen Shih; Fuh-Kwo Shiah; Chao-Chen Lai; Wen-Chen Chou; Jen-Hua Tai; Yu-Shun Wu; Cheng-Yang Lai; Chia-Ying Ko; Chin-Chang Hung (Frontiers in Marine Science, 2021)
Satellite-based observations of primary production (PP) are broadly used to assess carbon fixation rate of phytoplankton in the global ocean with small spatiotemporal limitations. However, the remote sensing can only reach the ocean surface, the assumption of a PP vertically exponential decrease with increasing depth from the surface to the bottom of euphotic zone may cause a substantial and potential discrepancy between in situ measurements and satellite-based observations of PP. This study compared euphotic zone integrated PP derived from measurements based on ship-based in situ incubation (i.e., PP in situ ) and those derived from the satellite-based vertically generalized production model (VGPM; PP VGPM ) for the period 2003∼2016 at the South East Asian Time-series Study (SEATS) station. PP values obtained during the NE-monsoon (NEM: Nov∼Mar; PP in situ = 323 ± 134; PP VGPM = 443 ± 142 mg-C m –2 d –1 ) were ∼2-fold higher than those recorded during the SW-monsoon (SWM: Apr∼Oct; PP in situ = 159 ± 58; PP VGPM = 250 ± 36 mg-C m –2 d –1 ), regardless of the method used for derivation. The main reason for the higher PP values during the NEM appears to have been a greater abundance of inorganic nutrients were made available by vertical advection. Note that on average, PP in situ estimates were ∼50% lower than PP VGPM estimates, regardless of the monsoon. These discrepancies can be mainly attributed to differences from the euphotic zone depth between satellite-based and in situ measurements. The significantly negative relationship between PP measurements obtained in situ and sea surface temperatures observed throughout this study demonstrates that both methods are effective indicators in estimating PP. Overall, our PP in situ analysis indicates that a warming climate is unfavorable for primary production in low-latitude open ocean ecosystems.

Two new sterol derivatives isolated from the endophytic fungus Aspergillus tubingensis YP-2 - Shui Yu; Yuan-Xing Zhu; Cheng Peng; Jiyang Li (Natural Product Research, 2021)

Aflatoxins from the endophytic fungus Aspergillus sp. Y-2 isolated from the critically endangered conifer Abies beshanzuensis - Yuan-Xing Zhu; Cheng Peng; Shui Yu; Jin-Feng Hu; Jiyang Li (Natural Product Research, 2021)

Implantation of Bone Marrow Mesenchymal Stem Cells into Small Intestinal Submucosa Improves Bile Duct Injury in Rabbits - Ying Li; Piao Wang; Xiao-dong Hu; Jing-da Zeng; Cheng Fang; Yu Gan; Fang-yi Peng; Xiao-li Yang; De Luo; Bo Li; Song Su (Tissue Engineering and Regenerative Medicine, 2021)

Human activity and climate change triggered the expansion of rocky desertification in the karst areas of Southwestern China - Chaojun Chen; Daoxian Yuan; Hai Cheng; Tsailuen Yu; Chuanchou Shen; R. Lawrence Edwards; Yao Wu; Siya Xiao; Jian Zhang; Tao Wang; Ran Huang; Ziqi Liu; et al. (Science China Earth Sciences, 2021)

Identification of RNA helicases in Medicago truncatula and their expression patterns under abiotic stress - Jie Cheng; Songsong Zhou; Kun Yang; Hongyang Yu; Rongrong Chen; Liming Zeng; Hua Li; Yihua Wang; Jianbo Song (Physiology and Molecular Biology of Plants, 2021)

SIRT1 Protects Dopaminergic Neurons in Parkinson’s Disease Models via PGC-1α-Mediated Mitochondrial Biogenesis - Yu Chen; Yuhui Jiang; Yinuo Yang; Xinzhong Huang; Cheng Sun (Neurotoxicity Research, 2021)

Complement C3 Aggravates Post-epileptic Neuronal Injury Via Activation of TRPV1 - Guang-Tong Jiang; Lin Shao; Shuo Kong; Meng-Liu Zeng; Jing-Jing Cheng; Tao-Xiang Chen; Song Han; Jun Yin; Wan-Hong Liu; Xiao-Hua He; Yu-Min Liu; Lanzi Gongga; et al. (Neuroscience Bulletin, 2021)

Investigation of the triggering mechanism and runout characteristics of an earthflow in Zhimei village, Chengduo, Qinghai, China - Mingzhe Zhang; Bao Zhou; Qiangong Cheng; Lingkai Shen; Aiguo Xing; Yu Zhuang (Natural Hazards, 2021)

SETD3 Downregulation Mediates PTEN Upregulation-Induced Ischemic Neuronal Death Through Suppression of Actin Polymerization and Mitochondrial Function - Xiangyu Xu; Yu Cui; Congqin Li; Yuyang Wang; Jing Cheng; Songfeng Chen; Jiangdong Sun; Jinyang Ren; Xujin Yao; Jingchen Gao; Xiaohong Huang; Qi Wan; et al. (Molecular Neurobiology, 2021)

Study on synthesis and anticancer activity of 17beta-estradiol-phenol/aniline nitrogen mustard derivatives - Yu-dong Yin; Jing-jing Liu; Wen-fei Liao; Xian-kun Guo; Li-shan Zhang; Wei-bin Mo; Ke-guang Cheng (Medicinal Chemistry Research, 2021)

Integrated 16S rRNA Gene Sequencing and LC-MS Analysis Revealed the Interplay Between Gut Microbiota and Plasma Metabolites in Rats With Ischemic Stroke - Wanfeng Wu; Yihang Sun; Ning Luo; Cheng Cheng; Chengting Jiang; Qingping Yu; Shaowu Cheng; Jinwen Ge (Journal of Molecular Neuroscience, 2021)

A study on the short-term effect of particulate matter pollution on hospital visits for asthma in children in Shanghai, China - Zhiang Yu; Yuxia Ma; Yifan Zhang; Bowen Cheng; Fengliu Feng; Bingji Ma; Haoran Jiao; Ji Zhou (Environmental Geochemistry and Health, 2021)

Effect of mangrove restoration on sediment properties and bacterial community - Xiao-Xia Ma; Zhao-Yu Jiang; Peng Wu; Yong-Fei Wang; Hao Cheng; You-Shao Wang; Ji-Dong Gu (Ecotoxicology, 2021)

Ocean acidification alters the thermal performance curves of brooded larvae from the reef coral Pocillopora damicornis - Lei Jiang; You-Fang Sun; Yu-Yang Zhang; Yuan Tian; Xin-Ming Lei; Guo-Wei Zhou; Tao Yuan; Xiang-Cheng Yuan; Sheng Liu; Hui Huang (Coral Reefs, 2021)

Plasticity of symbiont acquisition in new recruits of the massive coral Platygyra daedalea under ocean warming and acidification - Lei Jiang; Guo-Wei Zhou; Yu-Yang Zhang; Xin-Ming Lei; Tao Yuan; Ming-Lan Guo; Xiang-Cheng Yuan; Jian-Sheng Lian; Sheng Liu; Hui Huang (Coral Reefs, 2021)

An efficient genetic manipulation protocol for dark septate endophyte Falciphora oryzae - Zhen-Zhu Su; Meng-Di Dai; Jia-Nan Zhu; Yu-Lan Zeng; Xuan-Jun Lu; Xiao-Hong Liu; Fu-Cheng Lin (Biotechnology Letters, 2021)