Development of a dual-labeled, hydrolysis probe-based, real-time quantitative PCR assay for detection of both genotypes of duck circovirus-1 (DuCV-1) and DuCV-2 - Lin Zhang; Wenming Jiang; Fuyou Zhang; Yang Li; Jinping Li; Shaobo Liang; Xiaohui Yu; Cheng Peng; Shuo Liu; Jingjing Wang; Shuhong Sun; Hualei Liu (Virus Genes, 2021)

A Comparative Study of the Seismic Performances and Failure Mechanisms of Slopes Using Dynamic Centrifuge Modeling - Hualin Cheng; Jiamin Zhou; Zhiyi Chen; Yu Huang (Journal of Earth Science, 2021)

Geochemical characteristics of the lower Cambrian Qiongzhusi Formation in Huize area, east Yunnan: implications for paleo-ocean environment and the origin of black rock series - Yong Cheng; Weiqing Liu; Wei Wu; Yu Zhang; Guo Tang; Cong Liu; Qi Nie; Yiming Wen; Ping Lu; Chuanyu Zhang (Arabian Journal of Geosciences, 2021)

Vertical Fine-Scale Distribution of Calanus sinicus in the Yellow Sea Cold Water Mass During the Over-Summering Process - Jun Pan; Fangping Cheng; Fei Yu; Yongqiang Shi; Fan Sun; Guangcheng Si; Chuanjie Wei; Xinyuan Diao; Yongfang Zhao (Frontiers in Marine Science, 2021)
Calanus sinicus , a temperate copepod with a lethal temperature >27°C, is one of the key species in Chinese coastal marine ecosystems. The C. sinicus population increases in spring and declines in early summer annually due to increasing water temperature. Numerous C. sinicus individuals then congregate in the Yellow Sea Cold Water Mass (YSCWM) and remain under the thermocline from early summer to early autumn. Development and reproduction is halted in this cold and foodless bottom water and they avoid ascending to the hot surface water, which is regarded as an over-summering strategy. Based on discrete water sampling approaches, previous studies demonstrated that higher chlorophyll a (Chl a) levels appeared in the mixed hot surface water layer; however, the subsurface chlorophyll a maximum layer (SCML) has seldom been described. In the present study, various probes and a visual plankton recorder (VPR) were used to determine the fine vertical distributions of environmental factors and C. sinicus . VPR observations showed the ecological responses in fine scale and indicated that few C. sinicus individuals ascend at night, the main population preferred to remain below the SCML all day long. The results demonstrated that a constant thin SCML existed in the YSCWM area, and that the SCML location coincided with or was beneath the thermocline and halocline layers, where the temperature was suitable for C. sinicus . The relationship between abundance and Chl a, showed the diel vertical migration trend of C. sinicus to feed at night in the YSCWM area. In addition to temperature as a main influencing factor, dissolved oxygen concentrations and column depth were also influencing factors. Therefore, in addition to avoiding high surface temperature, energy supplement may be an important driving force confining the diel vertical migration of C. sinicus in the Yellow Sea in summer.

Inhibition of Candida albicans and induced vaginitis by sapindus water extract - Lu Li; Jindan Qiu; Minping Wei; Yunfei Xie; Hang Yu; Yahui Guo; Yuliang Cheng; Weirong Yao (Natural Product Research, 2021)

Association between large artery stenosis, cerebral small vessel disease and risk of ischemic stroke - Fei Han; Ding-Ding Zhang; Fei-Fei Zhai; Jun Xue; Jiang-Tao Zhang; Shuang Yan; Li-Xin Zhou; Jun Ni; Ming Yao; Meng Yang; Ming-Li Li; Zheng-Yu Jin; et al. (Science China Life Sciences, 2021)

Correlations between Dual-Pathway White Matter Alterations and Language Impairment in Patients with Aphasia: A Systematic Review and Meta-analysis - Jie Zhang; Shuchang Zhong; Liang Zhou; Yamei Yu; Xufei Tan; Min Wu; Peng Sun; Wei Zhang; Juebao Li; Ruidong Cheng; Yanfei Wu; Yanmei Yu; et al. (Neuropsychology Review, 2021)

Genetic analyses of gynecological disease identify genetic relationships between uterine fibroids and endometrial cancer, and a novel endometrial cancer genetic risk region at the WNT4 1p36.12 locus - Pik Fang Kho; Sally Mortlock; Frederic Amant; Daniela Annibali; Katie Ashton; John Attia; Paul L. Auer; Matthias W. Beckmann; Amanda Black; Louise Brinton; Daniel D. Buchanan; Stephen J. Chanock; et al. (Human Genetics, 2021)

Use of housefly (Musca domestica L.) larvae to bioconversion food waste for animal nutrition and organic fertilizer - Zhang Cheng; Lin Yu; Hahan Li; Xiaoxun Xu; Zhanbiao Yang (Environmental Science and Pollution Research, 2021)

Complex analysis of the personalized pharmacotherapy in the management of COVID-19 patients and suggestions for applications of predictive, preventive, and personalized medicine attitude - Lei-Yun Wang; Jia-Jia Cui; Qian-Ying OuYang; Yan Zhan; Yi-Min Wang; Xiang-Yang Xu; Lu-Lu Yu; Hui Yin; Yang Wang; Chen-Hui Luo; Cheng-Xian Guo; Ji-Ye Yin (EPMA Journal, 2021)
Aims Coronavirus disease 2019 (COVID-19) is rapidly spreading worldwide. Drug therapy is one of the major treatments, but contradictory results of clinical trials have been reported among different individuals. Furthermore, comprehensive analysis of personalized pharmacotherapy is still lacking. In this study, analyses were performed on 47 well-characterized COVID-19 drugs used in the personalized treatment of COVID-19. Methods Clinical trials with published results of drugs use for COVID-19 treatment were collected to evaluate drug efficacy. Drug-to-Drug Interactions (DDIs) were summarized and classified. Functional variations in actionable pharmacogenes were collected and systematically analysed. “Gene Score” and “Drug Score” were defined and calculated to systematically analyse ethnicity-based genetic differences, which are important for the safer use of COVID-19 drugs. Results Our results indicated that four antiviral agents (ritonavir, darunavir, daclatasvir and sofosbuvir) and three immune regulators (budesonide, colchicine and prednisone) as well as heparin and enalapril could generate the highest number of DDIs with common concomitantly utilized drugs. Eight drugs (ritonavir, daclatasvir, sofosbuvir, ribavirin, interferon alpha-2b, chloroquine, hydroxychloroquine (HCQ) and ceftriaxone had actionable pharmacogenomics (PGx) biomarkers among all ethnic groups. Fourteen drugs (ritonavir, daclatasvir, prednisone, dexamethasone, ribavirin, HCQ, ceftriaxone, zinc, interferon beta-1a, remdesivir, levofloxacin, lopinavir, human immunoglobulin G and losartan) showed significantly different pharmacogenomic characteristics in relation to the ethnic origin of the patient. Conclusion We recommend that particularly for patients with comorbidities to avoid serious DDIs, the predictive, preventive, and personalized medicine (PPPM, 3 PM) strategies have to be applied for COVID-19 treatment, and genetic tests should be performed for drugs with actionable pharmacogenes, especially in some ethnic groups with a higher frequency of functional variations, as our analysis showed. We also suggest that drugs associated with higher ethnic genetic differences should be given priority in future pharmacogenetic studies for COVID-19 management. To facilitate translation of our results into clinical practice, an approach conform with PPPM/3 PM principles was suggested. In summary, the proposed PPPM/3 PM attitude should be obligatory considered for the overall COVID-19 management.

Acute associations between air pollution on premature rupture of membranes in Hefei, China - Chao Zhang; Sha Li; Gan-lan Guo; Jing-wen Hao; Peng Cheng; Li-lin Xiong; Shu-ting Chen; Ji-yu Cao; Yu-wen Guo; Jia-hu Hao (Environmental Geochemistry and Health, 2021)

Viable and Heat-Killed Probiotic Strains Improve Oral Immunity by Elevating the IgA Concentration in the Oral Mucosa - Wen-Yang Lin; Yi-Wei Kuo; Ching-Wei Chen; Yu-Fen Huang; Chen-Hung Hsu; Jia-Hung Lin; Cheng-Ruei Liu; Jui-Fen Chen; Ko-Chiang Hsia; Hsieh-Hsun Ho (Current Microbiology, 2021)
Oral-nasal mucosal immunity plays a crucial role in protecting the body against bacterial and viral invasion. Safe probiotic products have been used to enhance human immunity and oral health. In this study, we verified the beneficial effects of mixed viable probiotic tablets, consisting of Lactobacillus salivarius subsp. salicinius AP-32, Bifidobacterium animalis subsp. lactis CP-9, and Lactobacillus paracasei ET-66, and heat-killed probiotic tablets, consisting of L. salivarius subsp. salicinius AP-32 and L. paracasei ET-66, on oral immunity among 45 healthy participants. Participants were randomly divided into viable probiotic, heat-killed probiotic, and placebo groups. The administration of treatment lasted for 4 weeks. Saliva samples were collected at Weeks 0, 2, 4, and 6, and Lactobacillus , Bifidobacterium and Streptococcus mutans populations and IgA concentration were measured. IgA concentrations, levels of TGF-beta and IL-10 in PBMCs cells were quantified by ELISA method. Results showed that salivary IgA levels were significantly increased on administration of both the viable (119.30 ± 12.63%, *** P < 0.001) and heat-killed (116.78 ± 12.28%, *** P < 0.001) probiotics for 4 weeks. Among three probiotic strains, AP-32 would effectively increase the levels of TGF-beta and IL-10 in PBMCs. The oral pathogen Streptococcus mutans was significantly reduced on viable probiotic tablet administration (49.60 ± 31.01%, *** P < 0.001). The in vitro antibacterial test confirmed that viable probiotics effectively limited the survival rate of oral pathogens. Thus, this clinical pilot study demonstrated that oral probiotic tablets both in viable form or heat-killed form could exert beneficial effects on oral immunity via IL-10, TGB-beta mediated IgA secretion. The effective dosage of viable probiotic content in the oral tablet was 10 9 CFUs/g and the heat-killed oral tablet was 1 × 10 10 cells/g.

Apatite as an alternative petrochronometer to trace the evolution of magmatic systems containing metamict zircon - Hao-Cheng Yu; Kun-Feng Qiu; Callum J. Hetherington; David Chew; Ya-Qi Huang; Deng-Yang He; Jian-Zhen Geng; Hai-Yang Xian (Contributions to Mineralogy and Petrology, 2021)

Human Methylmercury Exposure and Potential Impacts in Central Tibet: Food and Traditional Tibetan Medicine - Menghan Cheng; Maodian Liu; Dou Li; Qing Luo; Zhihao Zhang; Liuliang Yuan; Chenghao Yu; Han Xie; Huiming Lin; Qianru Zhang; De Ji; Xuejun Wang (Bulletin of Environmental Contamination and Toxicology, 2021)

Transport patterns and numerical simulation of heavy metal pollutants in soils of lead-zinc ore mines - Jie Cao; Cheng-yu Xie; Zhi-ru Hou (Journal of Mountain Science, 2021)

Antibacterial Mechanism of Liangguoan against Staphylococcus aureus and Escherichia coli - Yaoying Zeng; Qian Yu; Shujun Cheng (Archives of Microbiology, 2021)

Detrimental impact of hypoxia on the mortality, growth, reproduction, and enzyme activities of planktonic mysid Neomysis awatschensis - Qiao-ning Wang; Xiao-dong Li; Tian Yan; Jing-jing Song; Ren-cheng Yu; Ming-jiang Zhou (Aquatic Ecology, 2021)

Spatiotemporal characteristics and trend assessment of Ms ≥ 5.6 earthquakes in the Tianshan area of China based on co-occurrence analysis and commensurability - Jia Wan; Jun-Ping Yan; Zi-Qiang Liu; Xiao-Meng Wang; Yu-Feng Zhang; Cheng-Bo Wang (Applied Geophysics, 2021)

Thinner Sea Ice Contribution to the Remarkable Polynya Formation North of Greenland in August 2018 - Xiaoyi Shen; Chang-Qing Ke; Bin Cheng; Wentao Xia; Mengmeng Li; Xuening Yu; Haili Li (Advances in Atmospheric Sciences, 2021)
In August 2018, a remarkable polynya was observed off the north coast of Greenland, a perennial ice zone where thick sea ice cover persists. In order to investigate the formation process of this polynya, satellite observations, a coupled ice-ocean model, ocean profiling data, and atmosphere reanalysis data were applied. We found that the thinnest sea ice cover in August since 1978 (mean value of 1.1 m, compared to the average value of 2.8 m during 1978−2017) and the modest southerly wind caused by a positive North Atlantic Oscillation (mean value of 0.82, compared to the climatological value of −0.02) were responsible for the formation and maintenance of this polynya. The opening mechanism of this polynya differs from the one formed in February 2018 in the same area caused by persistent anomalously high wind. Sea ice drift patterns have become more responsive to the atmospheric forcing due to thinning of sea ice cover in this region.

Modulation of the 5-HT 3 A receptor current by desacylbaldrinal - Li-Xia Wang; Hu-Lan Chen; Hong-Ling Yan; Fei Tang; Hai Zhang; Hong-Xiang Li; Qiang Ye; Cheng Peng; Yu-Zhu Tan (Natural Product Research, 2021)

Flocculant effects on fluidity and strength behavior of cemented dredged clay with high water content - Gui-Zhong Xu; Cheng-Chun Qiu; Miao-Miao Song; Yu-Peng Cao; Jie- Yin (Marine Georesources & Geotechnology, 2021)

Influence of the Choice of Reference Planes on the Determination of 2D and 3D Joint Roughness Parameters - Louis Ngai Yuen Wong; Fanzhen Meng; Hui Zhou; Jin Yu; Guangtan Cheng (Rock Mechanics and Rock Engineering, 2021)

Investigation on Reservoir Stimulation Characteristics in Hot Dry Rock Geothermal Formations of China During Hydraulic Fracturing - Yuxiang Cheng; Yanjun Zhang; Ziwang Yu; Zhongjun Hu (Rock Mechanics and Rock Engineering, 2021)

GPR40 receptor agonist TAK-875 improves cognitive deficits and reduces β-amyloid production in APPswe/PS1dE9 mice - Chao Liu; Zhao-Yan Cheng; Qing-Peng Xia; Yu-Hui Hu; Chen Wang; Ling He (Psychopharmacology, 2021)

Assessment of climate change effects on alpine summit vegetation in the transition of tropical to subtropical humid climate - Chu-Chia Kuo; Yu Su; Ho-Yih Liu; Cheng-Tao Lin (Plant Ecology, 2021)

The major photoprotective role of anthocyanins in leaves of Arabidopsis thaliana under long-term high light treatment: antioxidant or light attenuator? - Xiao-Ting Zheng; Zheng-Chao Yu; Jun-Wei Tang; Min-Ling Cai; Yi-Lin Chen; Cheng-Wei Yang; Wah Soon Chow; Chang-Lian Peng (Photosynthesis Research, 2021)

Protective effect of myricetin on LPS-induced mastitis in mice through ERK1/2 and p38 protein author - Xingchi Kan; Juxiong Liu; Yingsheng Chen; Wenjin Guo; Dianwen Xu; Ji Cheng; Yu Cao; Zhanqing Yang; Shoupeng Fu (Naunyn-Schmiedeberg's Archives of Pharmacology, 2021)

Molecular cloning and sequence analysis of a mitogen-activated protein kinase gene in the Antarctic yeast Rhodotorula mucilaginosa AN5 - Cuijuan Shi; Hong Zhang; Kai Yu; Yingying Wang; Jie Jiang; Yun Ju; Chuanzhou Zhang; Ziyi Cheng; Guangfeng Kan (Molecular Biology Reports, 2021)

The mTOR/NF-κB Pathway Mediates Neuroinflammation and Synaptic Plasticity in Diabetic Encephalopathy - Ting Xu; Jiao Liu; Xin-rui Li; Yinghua Yu; Xuan Luo; Xian Zheng; Yuan Cheng; Pei-quan Yu; Yi Liu (Molecular Neurobiology, 2021)

Performance Comparison of the Deep Learning and the Human Endoscopist for Bleeding Peptic Ulcer Disease - Hsu-Heng Yen; Ping-Yu Wu; Pei-Yuan Su; Chia-Wei Yang; Yang-Yuan Chen; Mei-Fen Chen; Wen-Chen Lin; Cheng-Lun Tsai; Kang-Ping Lin (Journal of Medical and Biological Engineering, 2021)
Purpose Management of peptic ulcer bleeding is clinically challenging. Accurate characterization of the bleeding during endoscopy is key for endoscopic therapy. This study aimed to assess whether a deep learning model can aid in the classification of bleeding peptic ulcer disease. Methods Endoscopic still images of patients ( n = 1694) with peptic ulcer bleeding for the last 5 years were retrieved and reviewed. Overall, 2289 images were collected for deep learning model training, and 449 images were validated for the performance test. Two expert endoscopists classified the images into different classes based on their appearance. Four deep learning models, including Mobile Net V2, VGG16, Inception V4, and ResNet50, were proposed and pre-trained by ImageNet with the established convolutional neural network algorithm. A comparison of the endoscopists and trained deep learning model was performed to evaluate the model’s performance on a dataset of 449 testing images. Results The results first presented the performance comparisons of four deep learning models. The Mobile Net V2 presented the optimal performance of the proposal models. The Mobile Net V2 was chosen for further comparing the performance with the diagnostic results obtained by one senior and one novice endoscopists. The sensitivity and specificity were acceptable for the prediction of “normal” lesions in both 3-class and 4-class classifications. For the 3-class category, the sensitivity and specificity were 94.83% and 92.36%, respectively. For the 4-class category, the sensitivity and specificity were 95.40% and 92.70%, respectively. The interobserver agreement of the testing dataset of the model was moderate to substantial with the senior endoscopist. The accuracy of the determination of endoscopic therapy required and high-risk endoscopic therapy of the deep learning model was higher than that of the novice endoscopist. Conclusions In this study, the deep learning model performed better than inexperienced endoscopists. Further improvement of the model may aid in clinical decision-making during clinical practice, especially for trainee endoscopist.

Active components from Lagotis brachystachya maintain uric acid homeostasis by inhibiting renal TLR4-NLRP3 signaling in hyperuricemic mice - Ji-Xiao Zhu; Hai-Yan Yang; Wei-Qiong Hu; Jie Cheng; Yang Liu; Li-Tao Yi; Hong-Yu Cheng (Inflammopharmacology, 2021)

The trophocytes and oenocytes of worker and queen honey bees (Apis mellifera) exhibit distinct age-associated transcriptome profiles - Cheng-Yen Lu; Yu-Ting Weng; Bertrand Tan; Chin-Yuan Hsu (GeroScience, 2021)

Physical Model Tests on the Effect of Anchoring on the Splitting Failure of Deep Large-Scale Underground Rock Cavern - Guangyuan Yu; Qiangyong Zhang; Fan Li; Lei Cheng; Xin Guo (Geotechnical and Geological Engineering, 2021)

Maternal exposure to sulfur dioxide and the risk of oral clefts in Liaoning Province, China: a population-based case-control study - Fang-Hua Liu; Ze Xing; Ting-Ting Gong; Jia-Yu Zhang; Yan-Hong Huang; Jing Li; Shu Liu; Yan-Ling Chen; Li-Li Li; Cheng-Zhi Jiang; Zong-Jiao Chen; Yu-Hong Zhao; et al. (Environmental Science and Pollution Research, 2021)

Extensions of the distributed lag non-linear model (DLNM) to account for cumulative mortality - Chao-Yu Guo; Xing-Yi Huang; Pei-Cheng Kuo; Yi-Hau Chen (Environmental Science and Pollution Research, 2021)
The effects of meteorological factors on health outcomes have gained popularity due to climate change, resulting in a general rise in temperature and abnormal climatic extremes. Instead of the conventional cross-sectional analysis that focuses on the association between a predictor and the single dependent variable, the distributed lag non-linear model (DLNM) has been widely adopted to examine the effect of multiple lag environmental factors health outcome. We propose several novel strategies to model mortality with the effects of distributed lag temperature measures and the delayed effect of mortality. Several attempts are derived by various statistical concepts, such as summation, autoregressive, principal component analysis, baseline adjustment, and modeling the offset in the DLNM. Five strategies are evaluated by simulation studies based on permutation techniques. The longitudinal climate and daily mortality data in Taipei, Taiwan, from 2012 to 2016 were implemented to generate the null distribution. According to simulation results, only one strategy, named MV DLNM , could yield valid type I errors, while the other four strategies demonstrated much more inflated type I errors. With a real-life application, the MV DLNM that incorporates both the current and lag mortalities revealed a more significant association than the conventional model that only fits the current mortality. The results suggest that, in public health or environmental research, not only the exposure may post a delayed effect but also the outcome of interest could provide the lag association signals. The joint modeling of the lag exposure and the delayed outcome enhances the power to discover such a complex association structure. The new approach MV DLNM models lag outcomes within 10 days and lag exposures up to 1 month and provide valid results.

Rapid Surface-Enhanced Raman Spectroscopy Detection of Chlorothalonil in Standard Solution and Orange Peels with Pretreatment of Ultraviolet Irradiation - Hang Yu; Lebei Xu; Fangwei Yang; Yunfei Xie; Yahui Guo; Yuliang Cheng; Weirong Yao (Bulletin of Environmental Contamination and Toxicology, 2021)

Sum of High-Risk Gene Mutation (SHGM): A Novel Attempt to Assist Differential Diagnosis for Adrenocortical Carcinoma with Benign Adenoma, Based on Detection of Mutations of Nine Target Genes - Guo-Yang Zheng; Xue-Bin Zhang; Han-Zhong Li; Yu-Shi Zhang; Jian-Hua Deng; Xing-Cheng Wu (Biochemical Genetics, 2021)
There has been no research on applying gene detection to differential diagnosis of adrenocortical carcinoma (ACC). We attempted to explore a novel auxiliary method for differential diagnosis between ACC with benign adrenocortical adenoma (ACA), based on mutations of target genes in tissues. Nine genes were chosen as target genes, including TP53, CTNNB1, ARMC5, PRKAR1A, ZNRF3, RB1, APC, MEN1, and RPL22 . Exons sequencing of target genes were performed in 98 cases of tissue samples by FastTarget technology, including 41 ACC tissues, 32 ACA tissues, and 25 normal adrenal gland tissues. Significant mutations were detected and identified, and the clinical information was collected, for further comparative analysis and application to assist differential diagnosis of ACC. We identified 132 significant gene mutations and 227 significant mutation sites in 37 ACC tissues, much more than ACA and normal adrenal gland tissues. Mutation rates of 6 genes in ACC tissues were obviously higher than ACA tissues, including ZNRF3, ARMC5, TP53, APC, RB1, and PRKAR1A , regarded as high-risk genes. The sum of mutated high-risk genes detected in each sample was denominated sum of high-risk gene mutation (SHGM), and the rates of SHGM > 0 and SHGM > 1 in ACC tissues were 73.0% and 62.2%, respectively, both obviously higher than those in ACA tissues, with significant statistic differences. Especially for 8 cases of ACC with diameter 0 and SHGM > 1 were found in 6 samples (75%) and 4 samples (50%), respectively. However, no relevance was found between SHGM and clinical characteristics of ACC. We identified 6 high-risk genes in ACC tissues, with significantly higher mutation rates than ACA or normal adrenal gland tissues. The sum of mutated high-risk genes detected in ACC tissues was denominated SHGM, which was potential to assist the differential diagnosis of ACC with ACA, especially for the small-size ACC.

Enrichment of marine productivity utilizing steelmaking slag: managing conflicting stakeholders’ interests in Taiwan - Yung-Sheng Chen; Ming-Sheng Ko; Yu-Cheng Wang; Ping Chen; Ta-Kang Liu (Aquaculture International, 2021)

RSF1 requires CEBP/β and hSNF2H to promote IL-1β-mediated angiogenesis: the clinical and therapeutic relevance of RSF1 overexpression and amplification in myxofibrosarcomas - Chien-Feng Li; Ti-Chen Chan; Cheng-I. Wang; Fu-Min Fang; Po-Chun Lin; Shih-Chen Yu; Hsuan-Ying Huang (Angiogenesis, 2021)

5-HTTLPR polymorphism and depression risk in Parkinson's disease: an updated meta-analysis - Pengfei Cheng; Junxiang Zhang; Yu Wu; Wenting Liu; Jiaying Zhu; Ze Chen; Jiarui Zhang; Songwen Guan; Yiming Sun; Jingxia Wang (Acta Neurologica Belgica, 2021)

Quantifying nitrate pollution sources of the drinking water source area using a Bayesian isotope mixing model in the northeastern suburbs of Beijing, China - Liangsuo Ren; Lirong Cheng; Shurong Zhang; Aizhong Ding; Yi Zhu; Chunlei Lu; Yu Li; Qing Yang; Jie Li (Isotopes in Environmental and Health Studies, 2021)

Correction to: Delineation of potential hot spots of aeolian dust using normalized difference water index - Chao-Yuan Lin; Shu-Fen Tsai; Chih-Yun Wang; Cheng-Yu Lin (Theoretical and Applied Climatology, 2021)

Delineation of potential hot spots of aeolian dust using normalized difference water index - Chao-Yuan Lin; Shu-Fen Tsai; Chih-Yun Wang; Cheng-Yu Lin (Theoretical and Applied Climatology, 2021)

Genetic Analysis of ZNF Protein Family Members for Early-Onset Parkinson’s Disease in Chinese Population - Chun Yu Li; Ru Wei Ou; Yong Ping Chen; Xiao Jing Gu; Qian Qian Wei; Bei Cao; Ling Yu Zhang; Yan Bing Hou; Kun Cheng Liu; Xue Ping Chen; Wei Song; Bi Zhao; et al. (Molecular Neurobiology, 2021)

Acute exposure to microcystin-LR induces hepatopancreas toxicity in the Chinese mitten crab (Eriocheir sinensis) - Cheng Chi; Xia-Wei Yu; Cai-Yan Zhang; Jia-Dai Liu; Ming-Wen Ye; Ding-Dong Zhang; Wen-Bin Liu (Archives of Toxicology, 2021)

Glaciibacter flavus sp. nov., isolated from a lichen sample - De-Feng An; Long-Qian Jiang; Kun Zhang; Gui-Ding Li; Xin-Yu Wang; Ming-Guo Jiang; Lei Lang; Li-Song Wang; Johannes F. Imhoff; Cheng-Lin Jiang; Yi Jiang (Archives of Microbiology, 2021)

In-Situ Seawater Gamma Spectrometry with LaBr3 Detector at a Nuclear Power Plant Outlet - Daowei Dou; Zhi Zeng; Wen Yu; Ming Zeng; Wu Men; Feng Lin; Hao Ma; Jianping Cheng; Junli Li (Journal of Marine Science and Engineering, 2021)
In a nuclear emergency, the application of in situ spectrometers for monitoring environmental radioactivity is significantly important, as information on the type and activity of radionuclides released from the accident can be obtained quickly. However, in emergency environmental radiological monitoring, a balance between energy resolution and detecting efficiency must be considered in selecting an appropriate detector. In this study, in situ gamma spectrometry was conducted with the LaBr3 detector to determine the radioactivity of seawater at the discharging outlet of a coastal nuclear power plant in southeast China. The results show that the LaBr3 scintillator has excellent energy resolution and detection efficiency, making it a promising detector for emergency monitoring.

Detection of Vestibular Schwannoma on Triple-parametric Magnetic Resonance Images Using Convolutional Neural Networks - Tzu-Hsuan Huang; Wei-Kai Lee; Chih-Chun Wu; Cheng-Chia Lee; Chia-Feng Lu; Huai-Che Yang; Chun-Yi Lin; Wen-Yuh Chung; Po-Shan Wang; Yen-Ling Chen; Hsiu-Mei Wu; Wan-You Guo; et al. (Journal of Medical and Biological Engineering, 2021)
Purpose The first step in typical treatment of vestibular schwannoma (VS) is to localize the tumor region, which is time-consuming and subjective because it relies on repeatedly reviewing different parametric magnetic resonance (MR) images. A reliable, automatic VS detection method can streamline the process. Methods A convolutional neural network architecture, namely YOLO-v2 with a residual network as a backbone, was used to detect VS tumors from MR images. To heighten performance, T1-weighted–contrast-enhanced, T2-weighted, and T1-weighted images were combined into triple-channel images for feature learning. The triple-channel images were cropped into three sizes to serve as input images of YOLO-v2. The VS detection effectiveness levels were evaluated for two backbone residual networks that downsampled the inputs by 16 and 32. Results The results demonstrated the VS detection capability of YOLO-v2 with a residual network as a backbone model. The average precision was 0.7953 for a model with 416 × 416-pixel input images and 16 instances of downsampling, when both the thresholds of confidence score and intersection-over-union were set to 0.5. In addition, under an appropriate threshold of confidence score, a high average precision, namely 0.8171, was attained by using a model with 448 × 448-pixel input images and 16 instances of downsampling. Conclusion We demonstrated successful VS tumor detection by using a YOLO-v2 with a residual network as a backbone model on resized triple-parametric MR images. The results indicated the influence of image size, downsampling strategy, and confidence score threshold on VS tumor detection.

Three-dimensional Criterion for Predicting Peak Shear Strength of Matched Discontinuities with Different Joint Wall Strengths - Zhi Cheng Tang; Zhi Fei Zhang; Yu-Yong Jiao (Rock Mechanics and Rock Engineering, 2021)

In vitro regeneration and clonal fidelity assessment on induction and differentiation of protocorm-like body from Pleione bulbocodioides (Franch.) - Fangmei Zhou; Weipeng Huang; Wen Cheng; Jingjing Lu; Bingqi Zhu; Jie Yu; Zhishan Ding; Qianxing Jin (Plant Cell, Tissue and Organ Culture (PCTOC), 2021)

Novel disease resistance gene paralogs created by CRISPR/Cas9 in soy - Ervin D. Nagy; Julia L. Stevens; Neil Yu; Chris S. Hubmeier; Nona LaFaver; Megan Gillespie; Brian Gardunia; Qianshun Cheng; Steven Johnson; Audrey L. Vaughn; Miguel E. Vega-Sanchez; Mingqui Deng; et al. (Plant Cell Reports, 2021)
Key message Novel disease resistance gene paralogues are generated by targeted chromosome cleavage of tandem duplicated NBS-LRR gene complexes and subsequent DNA repair in soybean. This study demonstrates accelerated diversification of innate immunity of plants using CRISPR. Abstract Nucleotide-binding-site-leucine-rich-repeat (NBS-LRR) gene families are key components of effector-triggered immunity. They are often arranged in tandem duplicated arrays in the genome, a configuration that is conducive to recombinations that will lead to new, chimeric genes. These rearrangements have been recognized as major sources of novel disease resistance phenotypes. Targeted chromosome cleavage by CRISPR/Cas9 can conceivably induce rearrangements and thus emergence of new resistance gene paralogues. Two NBS-LRR families of soy have been selected to demonstrate this concept: a four-copy family in the Rpp1 region (Rpp1L) and a large, complex locus, Rps1 with 22 copies. Copy-number variations suggesting large-scale, CRISPR/Cas9-mediated chromosome rearrangements in the Rpp1L and Rps1 complexes were detected in up to 58.8% of progenies of primary transformants using droplet-digital PCR. Sequencing confirmed development of novel, chimeric paralogs with intact open reading frames. These novel paralogs may confer new disease resistance specificities. This method to diversify innate immunity of plants by genome editing is readily applicable to other disease resistance genes or other repetitive loci.

An underlying mechanism of qE deficiency in marine angiosperm Zostera marina - Wei Zhao; Quan Sheng Zhang; Ying Tan; Zhe Liu; Ming Yu Ma; Meng Xin Wang; Cheng Ying Luo (Photosynthesis Research, 2021)

Identification of differentially expressed genes associated with aluminum resistance in the soybean plant - Jing-xuan Wang; Bo Wang; Lu-bin Cui; Hao Xie; Run-zhi Li; Cheng Wang; Zhang-jie Nan; Yu-shu Liu; Jing-yu Ma; Yun-jin Sun; Wei-yu Li (Physiology and Molecular Biology of Plants, 2021)

Mucor rongii sp. nov., a New Cold-Tolerant Species from China - Feirong Bai; Su Yao; Chengshan Cai; Tianci Zhang; Yu Wang; Wei Liu; Baowen Ma; Changyuan Rong; Chi Cheng (Current Microbiology, 2021)

Climate response to introduction of the ESA CCI land cover data to the NCAR CESM - Shu Liu; Xiaoxuan Liu; Le Yu; Yong Wang; Guang J. Zhang; Peng Gong; Wenyu Huang; Bin Wang; Mengmiao Yang; Yuqi Cheng (Climate Dynamics, 2021)

A transcription factor TaTCP20 regulates the expression of Ppd-D1b in common wheat - Fan Wei; Tianqi Song; Jianfei Zhou; Jie Cheng; Ruibo Li; Ming Yu; Yunrui Zhang; Yang Yu; Bo Zhang; Xiaoke Zhang (Plant Biotechnology Reports, 2021)

Quantitative characterization of horizontal well production performance with multiple indicators: a case study on the Weiyuan shale gas field in the Sichuan Basin, China - Rongze Yu; Wei Guo; Lin Ding; Meizhu Wang; Feng Cheng; Xiaowei Zhang; Shangwen Zhou; Leifu Zhang (Frontiers of Earth Science, 2021)

Risk assessment of roof water disaster due to multi-seam mining at Wulunshan Coal Mine in China - Xianggang Cheng; Wei Qiao; Guofa Li; Zequan Yu (Arabian Journal of Geosciences, 2021)

Carbonate diagenetic facies of Yijianfang Formation (Shunbei area, Tarim Basin, Southeastern China) - Chuanjie Cheng; Chongyang Wu; Bingsong Yu; Weili Yang; Jun Liu; Rui Zhao; Zhuang Ruan (Arabian Journal of Geosciences, 2021)

Calculation of the safety thickness of water inrush with tunnel axis orthogonal to fault - Helin Fu; Pengtao An; Guowen Cheng; Jie Li; Zhen Huang; Xiaohui Yu (Arabian Journal of Geosciences, 2021)

Effect of selected sampling media, flow rate, and time on the sampling efficiency of a liquid impinger packed with glass beads for the collection of airborne viruses - Yen-Chi Chen; I-Jen Wang; Chih-Ching Cheng; Yu-Chiao Wu; Chun-Hsuan Bai; Kuo-Pin Yu (Aerobiologia, 2021)

Multiple diversity facets of crucial microbial groups in biological soil crusts promote soil multifunctionality - Hua Li; Youxin Chen; Gongliang Yu; Federico Rossi; Da Huo; Roberto De Philippis; Xiaoli Cheng; Weibo Wang; Renhui Li (Global Ecology and Biogeography, 2021)
Aim Microbial diversity is one of the most important factors for maintaining the performance of multiple functions in soils (multifunctionality). However, existing studies typically consider the taxonomic richness or Shannon diversity of the entire community. We know little about the connection network of taxonomic and phylogenetic facets of diversity and their collective impact on multifunctionality. In this study, the linkages of effects of diversity within functional groups were disentangled in drylands. Location The central Tibetan Plateau. Time period Present. Major taxa studied Phototrophs and diazotrophs (mainly cyanobacteria). Methods Given the carbon‐ and nitrogen‐limited nature of drylands, we conducted a high‐throughput sequencing of C/N‐fixing functional groups from biocrusts and evaluated multiple facets of diversity (i.e., richness, evenness and phylogeny‐related trait dissimilarity), together with seven crucial variables of soil functioning to calculate multifunctionality. The relationships between multifaceted diversity and abundance with individual functions and multifunctionality were validated by a set of solid statistical analyses. Results We found that the integrated biodiversity index was a stronger predictor of multifunctionality than richness. The divergent performance of different facets of diversity determined the idiosyncratic effect of each functional group on soil multifunctionality. Moreover, the evaluation of functional significance at the species level gave important clues on the trade‐offs and redundancy in each functional group, explaining the distinct patterns of effects of diversity. Richness was the dominant factor for diazotrophs to maximize multifunctionality, whereas phylogenetic dissimilarity was the essential one for phototrophs. Main conclusions Our study demonstrated that multiple facets of diversity should be considered when assessing the effects of biodiversity. In contrast to the community level, within‐functional group measures might adequately capture the features of diversity that are most correlated with soil multifunctionality. Our results provide a perspective to bridge the gap between taxonomic and trait‐based approaches for elucidating the biodiversity–ecosystem function relationship.

Design of supercontinuum laser hyperspectral light detection and ranging (LiDAR) (SCLaHS LiDAR) - Guoqing Zhou; Xiang Zhou; Youjian Song; Donghui Xie; Long Wang; Guangjian Yan; Minglie Hu; Bowen Liu; Weidong Shang; Chenghu Gong; Cheng Wang; Huaguo Huang; et al. (International Journal of Remote Sensing, 2021)

Chemical food contaminants during food processing: sources and control - Changjian Li; Changyan Li; Hang Yu; Yuliang Cheng; Yunfei Xie; Weirong Yao; Yahui Guo; He Qian (Critical Reviews in Food Science and Nutrition, 2021)

Association between functional brain alterations and neuropsychological scales in male chronic smokers using resting-state fMRI - Jun-Cheng Weng; Shih-Yu Huang; Ming-Shih Lee; Ming-Chou Ho (Psychopharmacology, 2021)

Reduction of OsMPK6 activity by a R89K mutation induces cell death and bacterial blight resistance in rice - Dongfei Wang; Hong Wang; Qunen Liu; Ranran Tu; Xingpeng Zhou; Yingxin Zhang; Weixun Wu; Ping Yu; Daibo Chen; Xiaodeng Zhan; Liyong Cao; Shihua Cheng; et al. (Plant Cell Reports, 2021)

Apatinib regulates the growth of gastric cancer cells by modulating apoptosis and autophagy - Xu Liu; Qiaoyu Zheng; Qiongfang Yu; Yan Hu; Yanmin Cheng; Zhaozhao Shao; Li Chen; Wenjie Ding; Dian Gao (Naunyn-Schmiedeberg's Archives of Pharmacology, 2021)

A comparative analysis of attabad landslide on january 4, 2010, using two numerical models - Hasnain Gardezi; Muhammad Bilal; Qiangong Cheng; Aiguo Xing; Yu Zhuang; Tahir Masood (Natural Hazards, 2021)

Experiments on granular flow behavior and deposit characteristics: implications for rock avalanche kinematics - Kun Li; Yu-Feng Wang; Qi-Wen Lin; Qian-Gong Cheng; Yue Wu (Landslides, 2021)

Establishment and characterization of 38 novel patient-derived primary cancer cell lines using multi-region sampling revealing intra-tumor heterogeneity of gallbladder carcinoma - Feiling Feng; Qingbao Cheng; Bin Li; Chen Liu; Huizhen Wang; Bin Li; Xiaoya Xu; Yong Yu; Zishuo Chen; Xiaobing Wu; Hua Dong; Kaijian Chu; et al. (Human Cell, 2021)
Gallbladder carcinoma (GBC) is a lethal biliary tract malignant neoplasm. Patient-derived primary cancer cell lines (PDPCs) are appropriate models to explore biological characteristics and potential therapeutics; however, there is a lack of PDPCs in GBC. In this study, we aimed to establish and characterize the GBC PDPCs, and further investigated the intra-tumor heterogeneity (ITH). Multi-region sampling (3–9 regions) of the operable tumor tissue samples was used to establish PDPCs. Short tandem repeat genotyping for cell authentication and karyotyping was performed, followed by whole-exome sequencing and RNA sequencing to assess the ITH at the genetic and transcriptional levels, respectively. Thirty-eight PDPCs were successfully established from seven GBC patients and characterized. ITH was observed with a median of 38.3% mutations being heterogeneous (range, 26.6–59.4%) across all patients. Similar with other tumor types, TP53 mutations were always truncal. In addition, there were three genes, KMT2C , CDKN2A , and ARID1A , with truncal mutations in at least two patients. A median of 370 differentially expressed genes (DEGs) was identified per patient. Distinct expression patterns were observed between major histocompatibility complex (MHC) class I and II genes. We found the expression of MHC class II genes in the PDPC samples was closely regulated by CIITA , while that of MHC class I genes were not correlated with CIITA expression. The PDPCs established from GBC patients can serve as novel in vitro models to identify the ITH, which may pave a crucial molecular foundation for enhanced understanding of tumorigenesis and progression.

Prediction of methane production from co-digestion of lignocellulosic biomass with sludge based on the major compositions of lignocellulosic biomass - Pengfei Li; Chao He; Chongbo Cheng; Youzhou Jiao; Dekui Shen; Ran Yu (Environmental Science and Pollution Research, 2021)

A 3-D morphological approach on spatial form and cultural identity of ethnic mountain settlements: Case from Guizhou, China - Zi-yu Jia; Cheng-yu Meng; Zheng-xu Zhou (Journal of Mountain Science, 2021)

Niacin stimulates EPH4EV mammary epithelial cell proliferation and mammary gland development in pubertal mice through activation of AKT/mTOR and ERK1/2 signaling pathways - Yu Cao; Yan Zhang; Lijun Ma; Jiaxin Wang; Wenjin Guo; Ji Cheng; Guiqiu Hu; Shoupeng Fu; Juxiong Liu (Cell and Tissue Research, 2021)

Influence of mechanical grinding on characterization of nanopores of tectonically deformed coal: a comparative study between coal chunks and crushed coal - Guoxi Cheng; Bo Jiang; Fengli Li; Yu Song (Arabian Journal of Geosciences, 2021)

Selection and optimum fertilization of Betula platyphylla hybrid clones for growth - Shuyuan Song; Siqi Cheng; Zhen Jia; Minghui Li; Jiabao Ji; Yifan Yang; Chu Wang; Chenrui Gu; Qibin Yu; Yuhui Weng; Guifeng Liu (Trees, 2021)

Effect of leaf water extracts of four Asteraceae alien invasive plants on germination performance of Lactuca sativa L. under acid deposition - Huiyuan Cheng; Shu Wang; Mei Wei; Youli Yu; Congyan Wang (Plant Ecology, 2021)

Simulation-based hazard management of a constructed landfill for flow slide scenario - Chongqiang Zhu; Hualin Cheng; Zhiyi Chen; Yu Huang (Natural Hazards, 2021)

Genetic Analysis of Prosaposin, the Lysosomal Storage Disorder Gene in Parkinson’s Disease - Yong-Ping Chen; Xiao-Jing Gu; Ru-Wei Ou; Ling-Yu Zhang; Yan-Bing Hou; Kun-Cheng Liu; Bei Cao; Qian-Qian Wei; Wei Song; Bi Zhao; Ying Wu; Jing-Qiu Cheng; et al. (Molecular Neurobiology, 2021)

Late Cretaceous granitic magmatism and Sn mineralization in the giant Yinyan porphyry tin deposit, South China: constraints from zircon and cassiterite U–Pb and molybdenite Re–Os geochronology - Peng-Cheng Hu; Wei-Guang Zhu; Hong Zhong; Rong-Qing Zhang; Xiao-Yu Zhao; Wei Mao (Mineralium Deposita, 2021)

Clinical Utility of Next-Generation Sequencing for Developmental Disorders in the Rehabilitation Department: Experiences from a Single Chinese Center - Yun Liu; Xiaomei Liu; Dongdong Qin; Yiming Zhao; Xuanlan Cao; Xiaoli Deng; Yu Cheng; Fuping Liu; Fang Yang; Tiesong Zhang; Xiu-An Yang (Journal of Molecular Neuroscience, 2021)

Microbiological profiles and antimicrobial resistance patterns of pediatric bloodstream pathogens in China, 2016–2018 - Yue Qiu; Junwen Yang; Yiping Chen; Jinhong Yang; Qingxiong Zhu; Chunhui Zhu; Shuangjie Li; Jing Liu; Chaomin Wan; Yu Zhu; Minxia Chen; Yi Xu; et al. (European Journal of Clinical Microbiology & Infectious Diseases, 2021)

Investigation on the dust migration behavior and safety zone in the fully mechanized mining face - Xin-xiao Lu; Cheng-yan Wang; Yun Xing; Cong Shen; Guo-yu Shi (Environmental Science and Pollution Research, 2021)

Response of non-point source pollution to landscape pattern: case study in mountain-rural region, China - Wuhua Li; Xiangju Cheng; Yu Zheng; Chengguang Lai; David J. Sample; Dantong Zhu; Zhaoli Wang (Environmental Science and Pollution Research, 2021)

Sensory acquisition functions of the cerebellum in verbal working memory - Jutta Peterburs; Yu Liang; Dominic T. Cheng; John E. Desmond (Brain Structure and Function, 2021)
Several fMRI studies have shown that the superior cerebellum exhibits load-dependent activations during encoding of letters in a Sternberg verbal working memory (VWM) task. It has been hypothesized that the cerebellum regulates the acquisition of sensory data across all modalities, and thus, that VWM load activations may reflect high- vs low-load differences in sensory acquisition demands. Therefore, increased difficulty in sensory data acquisition should elicit greater activation in the cerebellum. The present fMRI study manipulated sensory acquisition in VWM by presenting visually degraded and non-degraded stimuli with high and low memory loads, thereby identifying load-dependent regions of interest in the cerebellum, and then testing if these regions showed greater activation for degraded stimuli. Results yielded partial support for the sensory acquisition hypothesis in a load-dependent region of the vermis, which showed significantly greater activation for degraded relative to non-degraded stimuli. Because eye movements did not differ for these stimulus types, and degradation-related activations were present after co-varying eye movements, this activation appears to be related to perceptual rather than oculomotor demands. In contrast to the vermis, load-sensitive regions of the cerebellar hemispheres did not show increased activation for degraded stimuli. These findings point to an overall function of association-based prediction that may underlie general cerebellar function, with perceptual prediction of stimuli from partial representations occurring in the vermis, and articulatory prediction occurring in the hemispheres.

Perinatal Lead Exposure Alters Calsyntenin-2 and Calsyntenin-3 Expression in the Hippocampus and Causes Learning Deficits in Mice Post-weaning - Ning Li; Shuai Cao; Zengli Yu; Mingwu Qiao; Yongxia Cheng; Yue Shen; Lianjun Song; Xianqing Huang; Guojun Yang; Yali Zhao (Biological Trace Element Research, 2021)

Carbon isotope variations of modern soils in the eastern margin of the Tibetan Plateau and their controlling factors - Lin Qi; Yan-song Qiao; Zong-xiu Liu; Sha-sha Peng; Yu Cheng; Yan Wang; Xu-jiao Zhang; Ming-zhong Tian; Shuai-bin Yang; Wen-bin Bai (Journal of Mountain Science, 2021)

Mechanism of colluvial landslide induction by rainfall and slope construction: A case study - Zhou Zhou; Jun-hui Shen; Ying Li; Wei-feng Duan; Ri-chang Yang; Jun-cheng Shu; He-wei Li; Sheng-yu Tao; Sheng-zhe Zheng (Journal of Mountain Science, 2021)

Synchronous Characteristics of Precipitation Extremes in the Yangtze and Murray-Darling River Basins and the Role of ENSO - Yu Gong; Tong Jiang; Buda Su; Jinlong Huang; Zbigniew W. Kundzewicz; Cheng Jing; Hemin Sun (Journal of Meteorological Research, 2021)

Early morphological development of Erromyzon kalotaenia (Teleostei: Gastromyzontidae) - Wei-Cheng Jhuang; Kuo-Hsun Chiu; Te-Yu Liao (Ichthyological Research, 2021)

Carbon monoxide-triggered health effects: the important role of the inflammasome and its possible crosstalk with autophagy and exosomes - Rong-Jane Chen; Yu-Hsuan Lee; Tzu-Hao Chen; Yu-Ying Chen; Ya-Ling Yeh; Ching-Ping Chang; Chien-Cheng Huang; How-Ran Guo; Ying-Jan Wang (Archives of Toxicology, 2021)

The molecular mechanism of a novel derivative of BTO-956 induced apoptosis in human myelomonocytic lymphoma cells - Yu-Lin Li; De-Jun Zhou; Zheng-Guo Cui; Lu Sun; Qian-Wen Feng; Shahbaz Ahmad Zakki; Yusuke Hiraku; Cheng-Ai Wu; Hidekuni Inadera (Apoptosis, 2021)

Upper Ocean Temperatures Hit Record High in 2020 - Lijing Cheng; John Abraham; Kevin E. Trenberth; John Fasullo; Tim Boyer; Ricardo Locarnini; Bin Zhang; Fujiang Yu; Liying Wan; Xingrong Chen; Xiangzhou Song; Yulong Liu; et al. (Advances in Atmospheric Sciences, 2021)

An Insight into the Excavation-Induced Stress Paths on Mechanical Response of Weak Interlayer Zone in Underground Cavern Under High Geostress - Shu-Qian Duan; Quan Jiang; Guo-Feng Liu; Jie-Cheng Xiong; Po Gao; Ding-Ping Xu; Ming-Yu Li (Rock Mechanics and Rock Engineering, 2021)

The allelopathy of horseweed with different invasion degrees in three provinces along the Yangtze River in China - Huiyuan Cheng; Bingde Wu; Youli Yu; Shu Wang; Mei Wei; Congyan Wang; Daolin Du (Physiology and Molecular Biology of Plants, 2021)

Simulation of the fragmentation and propagation of jointed rock masses in rockslides: DEM modeling and physical experimental verification - Qi-wen Lin; Qian-Gong Cheng; Yu Xie; Feng-shou Zhang; Kun Li; Yu-feng Wang; Yuan-yuan Zhou (Landslides, 2021)

Groundwater sources, flow patterns, and hydrochemistry of the Central Yinchuan Plain, China - Ying Li; Ping Wu; Xiao-Qin Huang; Bo Zhang; Zhao-Xiang Xu; Yang Li; Jie Li; Lu-Chen Wang; Yu-Fang Sun; Xu-Chen Meng; Cheng-Wen Wang; Zi-Zhao Cai (Hydrogeology Journal, 2021)

Combining targeted sequencing and ultra-low-pass whole-genome sequencing for accurate somatic copy number alteration detection - Junfeng Fu; Weihua Guo; Cheng Yan; Zhenyang Lv; Yu Wang; Ze Wang; Zhe Fan; Ting Lei (Functional & Integrative Genomics, 2021)

The metabolic and immunological characteristics of pregnant women with COVID-19 and their neonates - Jingjiao Zhou; Yudie Wang; Juan Zhao; Lixing Gu; Cheng Yang; Jun Wang; Heng Zhang; Yu Tian; Hu Tuo; Dan Li; Min Wei; Bing He (European Journal of Clinical Microbiology & Infectious Diseases, 2021)

Maternal exposure to ambient SO2 and risk of polydactyly and syndactyly: a population-based case-control study in Liaoning Province, China - Yu-Ting Jiang; Ting-Ting Gong; Jia-Yu Zhang; Yan-Hong Huang; Jing Li; Shu Liu; Yan-Ling Chen; Li-Li Li; Cheng-Zhi Jiang; Zong-Jiao Chen; Yu-Hong Zhao; Qi-Jun Wu (Environmental Science and Pollution Research, 2021)

Delayed association of acute particulate matter 2.5 air pollution exposure with loss of complexity in cardiac rhythm dynamics: insight from detrended fluctuation analysis - Tsung-Ying Tsai; Li-Wei Lo; Shin-Huei Liu; Wen-Han Cheng; Yu-Hui Chou; Wei-Lun Lin; Yenn-Jiang Lin; Shih-Lin Chang; Yu-Feng Hu; Fa-Po Chung; Jo-Nan Liao; Tze-Fan Chao; et al. (Environmental Science and Pollution Research, 2021)

Long-term study of heavy metal pollution in the northern Hangzhou Bay of China: temporal and spatial distribution, contamination evaluation, and potential ecological risk - Hao Xu; Huahong Yang; Qiyun Ge; Zhenyi Jiang; Yang Wu; Yamei Yu; Deming Han; Jinping Cheng (Environmental Science and Pollution Research, 2021)

Polybrominated diphenyl ethers in soils from Tianjin, North China: distribution, health risk, and temporal trends - Yu Han; Jiali Cheng; Lei He; Minna Zhang; Shan Ren; Jiazheng Sun; Xiangyang Xing; Zhenwu Tang (Environmental Geochemistry and Health, 2021)

An analysis on the adoption of an interregional carbon emission reduction allocation approach in the context of China’s interprovincial carbon emission transfer - Yang Yang; Suocheng Dong; Fujia Li; Hao Cheng; Zehong Li; Yu Li; Shantong Li (Environment, Development and Sustainability, 2021)

Study on dynamic damage characteristics of coal under alternating hydraulic pressure - Qingfeng Xu; Yanbin Yu; Rulin Liu; Weimin Cheng; Haotian Yang (Bulletin of Engineering Geology and the Environment, 2021)

Resting‐State Functional Connectivity and Brain Network Abnormalities in Depressive Patients with Suicidal Ideation - Vincent Chin-Hung Chen; Yu-Syuan Chou; Yuan-Hsiung Tsai; Yin-Cheng Huang; Roger S. McIntyre; Jun-Cheng Weng (Brain Topography, 2021)

Effects of degradation succession of alpine wetland on soil organic carbon and total nitrogen in the Yellow River source zone, west China - Chun-ying Lin; Xi-lai Li; Jing Zhang; Hua-fang Sun; Juan Zhang; Hui-bang Han; Qi-hua Wang; Cheng-biao Ma; Cheng-yi Li; Yu-xing Zhang; Xue-qian Ma (Journal of Mountain Science, 2021)

Genomic characterization of a nebovirus strain with a novel RdRp genotype in yaks - Siyi Li; Huiqiang Ma; Zhonghua Yu; Hua Yue; Cheng Tang (Archives of Virology, 2021)

Pseudomonas laoshanensis sp. nov., isolated from peanut field soil - Ming-Qing Wang; Chu-Shu Zhang; Li-Na Yu; Wei-Qiang Yang; Kun Jiao; Kui-Jie Gong; Xiao-Yuan Chi; Jie Bi; Yu Song; Qing-Li Yang; Jian-Cheng Zhang; Gui-Wen Yang; et al. (Archives of Microbiology, 2021)

Simulation of coalbed methane generation, dissipation, and preservation and analysis of the geological influencing factors: a case study of the Xinjing coal mine, northeastern Qinshui basin, China - Fengli Li; Bo Jiang; Chongtao Wei; Guoxi Cheng; Yu Song (Arabian Journal of Geosciences, 2021)

Transcriptome analysis in Takifugu rubripes and Dicentrarchus labrax gills during Cryptocaryon irritans infection - Jian‐xin Cheng; Yu‐qing Xia; Ya‐fang Liu; Peng‐fei Liu; Ying Liu (Journal of Fish Diseases, 2021)
Takifugu rubripes and Dicentrarchus labrax are important commercial fish in China that are under serious threat from Cryptocaryon irritans . C. irritans is a ciliated obligate parasite that causes marine white spot disease and leads to heavy economic losses. We analysed the transcriptome in the gills of T. rubripes and D. labrax to compare differentially expressed genes (DEGs) and pathways during infection with C. irritans . In total, we identified 6,901 and 35,736 DEGs from T. rubripes and D. labrax , respectively. All DEGs were annotated into GO terms; 6,901 DEGs from T. rubripes were assigned into 991 sub‐categories, and 35,736 DEGs from D. labrax were assigned into 8,517 sub‐categories. We mapped DEGs to the KEGG database and obtained 153 and 350 KEGG signalling pathways from T. rubripes and D. labrax , respectively. Immune‐related categories included Toll‐like receptors, MAPK, lysosome, C‐type lectin receptor and NOD‐like receptor signalling pathways were significantly enriched pathways. In immune‐related signalling pathways, we found that AP‐1 , P38 , IL‐1β , HSP90 and PLA were significantly up‐regulated DEGs in T. rubripes , but P38 and PLA were significantly down‐regulated in D. labrax . In this study, transcriptome was used to analyse the difference between scaly and non‐scaly fish infection by C. irritans , which not only provided a theoretical basis for the infection mechanism of C. irritans , but also laid a foundation for effectively inhibiting the occurrence of this disease. Our work provides further insight into the immune response of host resistance to C. irritans .

The MYB transcription factor Baymax1 plays a critical role in rice male fertility - Xiao-Jiao Xiang; Lian-Ping Sun; Ping Yu; Zheng-Fu Yang; Pei-Pei Zhang; Ying-Xin Zhang; Wei-Xun Wu; Dai-Bo Chen; Xiao-Deng Zhan; Riaz-Muhammad Khan; Adil Abbas; Shi-Hua Cheng; et al. (Theoretical and Applied Genetics, 2021)

Estimation of rice plant potassium accumulation based on non-negative matrix factorization using hyperspectral reflectance - Jingshan Lu; Wanyu Li; Minglei Yu; Xiangbin Zhang; Yong Ma; Xi Su; Xia Yao; Tao Cheng; Yan Zhu; Weixing Cao; Yongchao Tian (Precision Agriculture, 2021)

Heat-Killed Lactobacillus reuteri GMNL-263 Inhibits Systemic Lupus Erythematosus–Induced Cardiomyopathy in NZB/W F1 Mice - Yu-Lan Yeh; Min-Chi Lu; Bruce Chi-Kang Tsai; Bor-Show Tzang; Shiu-Min Cheng; Xiaoyong Zhang; Liang-Yo Yang; B. Mahalakshmi; Wei-Wen Kuo; Peng Xiang; Chih-Yang Huang (Probiotics and Antimicrobial Proteins, 2021)

De novo transcriptome assembly of transgenic tobacco (Nicotiana tabacum NC89) with early senescence characteristic - Heng Liu; Yu Liu; Nini Cheng; Yuanhu Zhang (Physiology and Molecular Biology of Plants, 2021)

Projections from Infralimbic Cortex to Paraventricular Thalamus Mediate Fear Extinction Retrieval - Yan Tao; Cheng-Yun Cai; Jia-Yun Xian; Xiao-Lin Kou; Yu-Hui Lin; Cheng Qin; Hai-Yin Wu; Lei Chang; Chun-Xia Luo; Dong-Ya Zhu (Neuroscience Bulletin, 2021)

Expression of transient receptor potential vanilloid genes and proteins in diabetic rat heart - Xiaoli Jia; Tao Yu; Chao Xiao; Deqiao Sheng; Mengcheng Yang; Quanyi Cheng; Jing Wu; Ting Lian; Yun Zhao; Shizhong Zhang (Molecular Biology Reports, 2021)

Diversity-oriented synthesis and antifungal activities of novel pimprinine derivative bearing a 1,3,4-oxadiazole-5-thioether moiety - Zi-Long Song; Yun Zhu; Jing-Rui Liu; Shu-Ke Guo; Yu-Cheng Gu; Xinya Han; Hong-Qiang Dong; Qi Sun; Wei-Hua Zhang; Ming-Zhi Zhang (Molecular Diversity, 2021)

miR-9-5p facilitates hepatocellular carcinoma cell proliferation, migration and invasion by targeting ESR1 - Libing Wang; Mingxin Cui; Daming Cheng; Fengzhi Qu; Jingkun Yu; Yanbin Wei; Ling Cheng; Xiaotang Wu; Xiaogang Liu (Molecular and Cellular Biochemistry, 2021)

Level of in vitro storage of the European catfish (Silurus glanis L.) eggs at different temperatures - Merve Tinkir; Devrim Memiş; Yu Cheng; Miaomiao Xin; Marek Rodina; David Gela; Vladimíra Tučková; Otomar Linhart (Fish Physiology and Biochemistry, 2021)

Nickel ferrite nanoenabled graphene oxide (NiFe2O4@GO) as photoactive nanocomposites for water treatment - Allen Rhay B. Bayantong; Yu-Jen Shih; Cheng-Di Dong; Sergi Garcia-Segura; Mark Daniel G. de Luna (Environmental Science and Pollution Research, 2021)

Effects of lithium resource exploitation on surface water at Jiajika mine, China - Juan-Qin Gao; Yang Yu; Deng-Hong Wang; Wei Wang; Cheng-Hui Wang; Hong-Zhang Dai; Xue-Feng Hao; Kuang Cen (Environmental Monitoring and Assessment, 2021)

Paracoccus lichenicola sp. nov., Isolated from Lichen - Lei Lang; De-Feng An; Long-Qian Jiang; Gui-Ding Li; Li-Song Wang; Xin-Yu Wang; Qin-Yuan Li; Cheng-Lin Jiang; Yi Jiang (Current Microbiology, 2021)

Rapid assessment of landslide risk level based on deep learning - Fei Tan; Jin Yu; Yu-Yong Jiao; Dawei Lin; Jiahe Lv; Yi Cheng (Arabian Journal of Geosciences, 2021)

Infestation and distribution of gamasid mites on Himalayan field rat (Rattus nitidus) in Yunnan Province of Southwest China - Rong Xiang; Xian-Guo Guo; Cheng-Fu Zhao; Rong Fan; Ke-Yu Mao; Zhi-Wei Zhang; Xiao-Bin Huang (Biologia, 2021)

Prediction of Jacking Force in Vertical Tunneling Projects Based on Neuro-Genetic Models - Xin-Jiang Wei; Xiao Wang; Gang Wei; Cheng-Wei Zhu; Yu Shi (Journal of Marine Science and Engineering, 2021)
The vertical tunneling method is an emerging technique to build sewage inlets or outlets in constructed horizontal tunnels. The jacking force used to drive the standpipes upward is an essential factor during the construction process. This study aims to predict the jacking forces during the vertical tunneling construction process through two intelligence systems, namely, artificial neural networks (ANNs) and hybrid genetic algorithm optimized ANNs (GA-ANNs). In this paper, the Beihai hydraulic tunnel constructed by the vertical tunneling method in China is introduced, and the direct shear tests have been conducted. A database composed of 546 datasets with ten inputs and one output was prepared. The effective parameters are classified into three categories, including tunnel geometry factors, the geological factor, and jacking operation factors. These factors are considered as input parameters. The tunnel geometry factors include the jacking distance, the thickness of overlaying soil, and the height of overlaying water; the geological factor refers to the geological conditions; and the jacking operation factors consist of the dead weight of standpipes, effective overburden soil pressure, effective lateral soil pressure, average jacking speed, construction hours, and soil weakening measure. The output parameter, on the other hand, refers to the jacking force. Performance indices, including the coefficient of determination (R2), root mean square error (RMSE), and the absolute value of relative error (RE), are computed to compare the performance of the ANN models and the GA-ANN models. Comparison results show that the GA-ANN models perform better than the ANN model, especially on the RMSE values. Finally, parametric sensitivity analysis between the input parameters and output parameter is conducted, reaching the result that the height of overlaying water, the average jacking speed, and the geological condition are the most effective input parameters on the jacking force in this study.

Study on the small strain shear modulus of saturated sand-fines mixtures by bender element test - Bin Ruan; Yu Miao; Ke Cheng; Er-lei Yao (European Journal of Environmental and Civil Engineering, 2021)

Risk of incident gastroesophageal reflux disease (GERD) in patients with sleep disorders: a population-based cohort study - Yu-Hsien Cheng; Tao-Hsin Tung; Pei-En Chen; Ching-Yao Tsai (Sleep and Biological Rhythms, 2021)

Mapping the permafrost stability on the Tibetan Plateau for 2005–2015 - Youhua Ran; Xin Li; Guodong Cheng; Zhuotong Nan; Jinxing Che; Yu Sheng; Qingbai Wu; Huijun Jin; Dongliang Luo; Zhiguang Tang; Xiaobo Wu (Science China Earth Sciences, 2021)

MiR396 regulatory network and its expression during grain development in wheat - Yi Yu; Fangyao Sun; Ning Chen; Genlou Sun; Cheng-Yu Wang; De-Xiang Wu (Protoplasma, 2021)

Comparative genomic analysis of superoxide dismutase (SOD) genes in three Rosaceae species and expression analysis in Pyrus bretschneideri - Guohui Li; Fei Hu; Yang Zhang; Yu Zhao; Han Wang; Tianzhe Chen; Xi Cheng; Yongping Cai (Physiology and Molecular Biology of Plants, 2021)

Effects of Different Component Contents of Colistin Methanesulfonate on the Pharmacokinetics of Prodrug and Formed Colistin in Human - Ya-Xin Fan; Yuan-Cheng Chen; Yi Li; Ji-Cheng Yu; Xing-Chen Bian; Xin Li; Wan-Zhen Li; Bei-Ning Guo; Hai-Lan Wu; Xiao-Fen Liu; Yu Wang; Xiao-Yong Xu; et al. (Pharmaceutical Research, 2021)

Two new species of Panellus (Agaricales, Basidiomycota) from China - Qiu-Yue Zhang; Yu-Cheng Dai (Mycological Progress, 2021)

Two new species of Physisporinus (Polyporales, Basidiomycota) from Yunnan, Southwest China - Jia-Jia Chen; Yu-Cheng Dai (Mycological Progress, 2021)

Morphological, anatomical and photosynthetic consequences of artificial allopolyploidization in Cucumis - Xiaqing Yu; Yufei Zhai; Panqiao Wang; Chunyan Cheng; Ji Li; Qunfeng Lou; Jinfeng Chen (Euphytica, 2021)

High bioremediation potential of strain Chenggangzhangella methanolivorans CHL1 for soil polluted with metsulfuron-methyl or tribenuron-methyl in a pot experiment - Ting-Ting Yang; Hui-Wen Zhang; Jian Wang; Xin-Yu Li; Xu Li; Zhen-Cheng Su (Environmental Science and Pollution Research, 2021)

Constructed wetlands integrated with microbial fuel cells for COD and nitrogen removal affected by plant and circuit operation mode - Huiyang Wen; Hui Zhu; Baixing Yan; Brian Shutes; Xiangfei Yu; Rui Cheng; Xin Chen; Xinyi Wang (Environmental Science and Pollution Research, 2021)

Assessment of toxic elements in road dust from Hutou Village, China: implications for the highest incidence of lung cancer - Zailin Chen; Yi Huang; Xin Cheng; Shijun Ni; Jinjin Wang; Bangzheng Ren; Qiulian Yu (Environmental Science and Pollution Research, 2021)

Does regional innovation system efficiency facilitate energy-related carbon dioxide intensity reduction in China? - Kangjuan Lv; Yu Cheng; Yousen Wang (Environment, Development and Sustainability, 2021)

A new self-starting drainage method for slope stabilization and its application - Hong-yue Sun; Qi Ge; Yang Yu; Fei-xiang Shuai; Cheng-cheng Lü (Bulletin of Engineering Geology and the Environment, 2021)

Characterization of a recombinant sucrose isomerase and its application to enzymatic production of isomaltulose - Feng Zhang; Feng Cheng; Dong-Xu Jia; Yue-Hao Gu; Zhi-Qiang Liu; Yu-Guo Zheng (Biotechnology Letters, 2021)

Improving the observation and prediction capabilities for Arctic marine environment: from the perspective of Arctic Shipping - Hui Wang; Qizhen Sun; Lin Zhang; Xi Liang; Qinghua Yang; Na Liu; Chunhua Li; Qingsheng Liu; Bingrui Li; Qian Feng; Xiao Cheng; Yi Yu (Acta Oceanologica Sinica, 2021)

CD40 induces an antimicrobial response against the intracellular pathogen Streptococcus agalactiae in Nile tilapia, Oreochromis niloticus - Hongli Xia; Huimin Fan; Meng Long; Jun Cheng; Wenjie Chen; Dapeng Yu; Liqun Xia; Yishan Lu (Journal of Fish Diseases, 2021)
Streptococcus agalactiae is a Gram‐positive facultative intracellular bacterium that leads to severe economic loss of tilapia worldwide. Previous studies demonstrated that CD40 contributes to host protection against intracellular injection. In this study, CD40 was characterized from Nile tilapia ( Oreochromis niloticus ), named OnCD40. Sequence analysis showed that open reading frame of OnCD40 was 933 bp, containing a single peptide, a transmembrane domain and four cysteine‐rich domains. The qRT‐PCR revealed that OnCD40 was expressed in all examined tissues with the most abundant ones in spleen and thymus. After S. agalactiae stimulation, the expression of OnCD40 was significantly induced in most of the detected organs. Moreover, OnCD40‐overexpressing fish elicited significant protection against subsequent S. agalactiae challenge; approximately 10000‐fold fewer bacteria were detected in spleen of OnCD40‐overexpressing fish in comparison with control fish. Thus, CD40 had protecting function in Nile tilapia against intracellular pathogens.

Climate‐induced nonlinearity in pelagic communities and non‐stationary relationships with physical drivers in the Kuroshio ecosystem - Shuyang Ma; Yongjun Tian; Caihong Fu; Haiqing Yu; Jianchao Li; Yang Liu; Jiahua Cheng; Rong Wan; Yoshiro Watanabe (Fish and Fisheries, 2021)
Climate‐induced nonlinearity in biological variability and non‐stationary relationships with physical drivers are crucial to understand responses of marine organisms to climate variability. These phenomena have raised concerns in the northeastern North Pacific, but are out of the spotlight in the northwestern North Pacific in spite of potential implications for this productive system under increased climate variability. Pelagic communities in the Kuroshio ecosystem have both ecological and economic importance. However, patterns of climate‐induced nonlinearity in pelagic communities are not well understood, and existence of non‐stationarity in their relationships with physical drivers remains obscure. Here, we compile large numbers of climatic, oceanic and biological long‐term time‐series data and employ diverse statistical techniques to reveal such climate‐induced nonlinearity and non‐stationarity. Results show that pelagic communities in the Tsushima and Pacific areas (major areas in the Kuroshio ecosystem) had regime shifts in the late 1990s and late 1980s, respectively. Winter sea surface temperatures in the Kuroshio Current path and in the eastern part of East China Sea, which are respectively affected by the Kuroshio Current and Siberian High, correlate with dominant variability patterns in their pelagic communities. Furthermore, non‐stationarity was identified with threshold years in the 1990s in the Tsushima area and in the 1980s in the Pacific area as a possible result of the declined variances in the Siberian High and Aleutian Low, respectively. Our findings provide insights on spatial differentiation of climate‐induced nonlinearity and non‐stationarity, which are valuable for the management of pelagic communities in the northwestern North Pacific under changing climatic conditions.

Two new lignans from Zanthoxylum armatum - Yan Sun; Qing-Hong Zeng; Hui-Qiang Lu; Fan-Cheng Meng; Yong Shen; Wei-You Zeng; Hao Chi; Yu-Qiang Zhou; Min Chen (Natural Product Research, 2020)

Concurrent increases in post-pacing action potential duration and contractility predict occurrence of ventricular arrhythmia - Chih-Min Liu; Feng-Zhi Lin; Yao-Chang Chen; Yung-Kuo Lin; Yen-Yu Lu; Cheng-I Wu; Satoshi Higa; Shih-Ann Chen; Yi-Jen Chen (Pflügers Archiv - European Journal of Physiology, 2020)

Drought monitoring in Yunnan Province based on a TRMM precipitation product - Yuanhe Yu; Jinliang Wang; Feng Cheng; Huan Deng; Sheng Chen (Natural Hazards, 2020)

Genome-wide analysis of chloride channel-encoding gene family members and identification of CLC genes that respond to Cl−/salt stress in upland cotton - Xun Liu; Boyi Pi; Jianwei Pu; Cong Cheng; Jiajia Fang; Bingjun Yu (Molecular Biology Reports, 2020)

Clinical characteristics and plasma antibody titer of patients with COVID-19 in Zhejiang, China - Wei-ling Xiang; Jing-jing Cheng; Lian-peng Wu; Bing-yu Chen; Wen-xin Li; Dan-ying Qiu; Wei Zhang; Fei-hang Ge; Dong Chen; Zhen Wang (Journal of Zhejiang University-SCIENCE B, 2020)

Rhizobacterial communities and fine root traits together reveal variations in growth performance of Quercus acutissima in different provenances - Xiangrong Cheng; Haijing Yuan; Haidong Xu; Wenli Xing; Yangdong Wang; Mukui Yu (European Journal of Forest Research, 2020)

Effects of provenance and initial planting density on growth and wood properties in young sawtooth oak (Quercus acutissima) plantations - Xiangrong Cheng; Haijing Yuan; Wenli Xing; Yangdong Wang; Mukui Yu (European Journal of Forest Research, 2020)

A review of the impact of outdoor and indoor environmental factors on human health in China - Yuxia Ma; Yifan Zhang; Bowen Cheng; Fengliu Feng; Haoran Jiao; Xiaoyan Zhao; Bingji Ma; Zhiang Yu (Environmental Science and Pollution Research, 2020)

Geographical origin differentiation of Chinese Angelica by specific metal element fingerprinting and risk assessment - Lei Sun; Xiao Ma; Hong-Yu Jin; Chang-jun Fan; Xiao-dong Li; Tian-Tian Zuo; Shuang-Cheng Ma; Sicen Wang (Environmental Science and Pollution Research, 2020)

Variability in the global energy budget and transports 1985–2017 - Chunlei Liu; Richard P. Allan; Michael Mayer; Patrick Hyder; Damien Desbruyères; Lijing Cheng; Jianjun Xu; Feng Xu; Yu Zhang (Climate Dynamics, 2020)
The study of energy flows in the Earth system is essential for understanding current climate change. To understand how energy is accumulating and being distributed within the climate system, an updated reconstruction of energy fluxes at the top of atmosphere, surface and within the atmosphere derived from observations is presented. New satellite and ocean data are combined with an improved methodology to quantify recent variability in meridional and ocean to land heat transports since 1985. A global top of atmosphere net imbalance is found to increase from 0.10 ± 0.61 W m −2 over 1985–1999 to 0.62 ± 0.1 W m −2 over 2000–2016, and the uncertainty of ± 0.61 W m −2 is related to the Argo ocean heat content changes (± 0.1 W m −2 ) and an additional uncertainty applying prior to 2000 relating to homogeneity adjustments. The net top of atmosphere radiative flux imbalance is dominated by the southern hemisphere (0.36 ± 0.04 PW, about 1.41 ± 0.16 W m −2 ) with an even larger surface net flux into the southern hemisphere ocean (0.79 ± 0.16 PW, about 3.1 ± 0.6 W m −2 ) over 2006–2013. In the northern hemisphere the surface net flux is of opposite sign and directed from the ocean toward the atmosphere (0.44 ± 0.16 PW, about 1.7 ± 0.6 W m −2 ). The sea ice melting and freezing are accounted for in the estimation of surface heat flux into the ocean. The northward oceanic heat transports are inferred from the derived surface fluxes and estimates of ocean heat accumulation. The derived cross-equatorial oceanic heat transport of 0.50 PW is higher than most previous studies, and the derived mean meridional transport of 1.23 PW at 26° N is very close to 1.22 PW from RAPID observation. The surface flux contribution dominates the magnitude of the oceanic transport, but the integrated ocean heat storage controls the interannual variability. Poleward heat transport by the atmosphere at 30° N is found to increase after 2000 (0.17 PW decade −1 ). The multiannual mean (2006–2013) transport of energy by the atmosphere from ocean to land is estimated as 2.65 PW, and is closely related to the ENSO variability.

Serological evidence of the infection of H7 virus and the co-infection of H7 and H9 viruses in farmed fur–bearing animals in eastern China - Zhijun Yu; Kaihui Cheng; Jiaqiang Wu (Brazilian Journal of Microbiology, 2020)

Identification of hybrid green peafowl using mitochondrial and nuclear markers - Han Yu Du; Xin Yuan Zhang; Thi Dao Dinh; Yue Ma; Cheng Zong; Guang Long Li; Thomas D. Dahmer; Yan Chun Xu (Conservation Genetics Resources, 2020)

Sphingosylphosphorylcholine alleviates hypoxia-caused apoptosis in cardiac myofibroblasts via CaM/p38/STAT3 pathway - Ying Li; Qi Qi; Wan-cheng Yang; Tian-liang Zhang; Chen-chen Lu; Yu-juan Yao; Wei-hua Kong; Jing Zhao (Apoptosis, 2020)

Chemical constituents from common vetch ( Vicia sativa L.) and their antioxidant and cytotoxic activities - Li-Fang Liu; Wen-Hai Li; Man-Yu Li; Xiao-Zhen Wu; Fan Yang; Jia-Nan Xu; Cheng-Shan Yuan (Natural Product Research, 2020)

Analysis of genetic architecture and favorable allele usage of agronomic traits in a large collection of Chinese rice accessions - Xiuxiu Li; Zhuo Chen; Guomin Zhang; Hongwei Lu; Peng Qin; Ming Qi; Ying Yu; Bingke Jiao; Xianfeng Zhao; Qiang Gao; Hao Wang; Yunyu Wu; et al. (Science China Life Sciences, 2020)

Physiological and transcriptional response to heat stress in heat-resistant and heat-sensitive maize (Zea mays L.) inbred lines at seedling stage - De-Chuan Wu; Jia-Fei Zhu; Zhong-Ze Shu; Wei Wang; Cheng Yan; Shan-Bin Xu; De-Xiang Wu; Cheng-Yu Wang; Zhao-rong Dong; Genlou Sun (Protoplasma, 2020)

WDR5a functions in cadmium-inhibited root meristem growth by regulating nitric oxide accumulation in Arabidopsis - Yu Zhang; Yang-Yang Tian; Lin-Feng Wang; Yun-Hui Li; Ting-Ting Li; Wen-Cheng Liu (Planta, 2020)

Identification of AP2/ERF genes in apple (Malus × domestica) and demonstration that MdERF017 enhances iron deficiency tolerance - Li Cheng; Tong Zhao; Yu-Xia Wu; Hai Wang; Zhong-Xing Zhang; De Zhang; Shuang-Cheng Wang; Yan-Xiu Wang (Plant Cell, Tissue and Organ Culture (PCTOC), 2020)

The effect of blastomere loss during frozen embryo transfer on the transcriptome of offspring’s umbilical cord blood - Yan-Ting Wu; Ze-Han Dong; Cheng Li; Dai-Zhan Zhou; Jun-Yu Zhang; Yan Wu; Jing-Jing Xu; Yu Wang; Xiao-Qun Ye; Jian-Zhong Sheng; Li Wang; He-Feng Huang (Molecular Biology Reports, 2020)

Optimizing the MIC breakpoints of amoxicillin and tetracycline for antibiotic selection in the rescue therapy of H. pylori with bismuth quadruple regimen - Ming-Tsung Hsieh; Wei-Lun Chang; Chung-Tai Wu; Hsiao-Bai Yang; Hsin-Yu Kuo; Meng-Ying Lin; Hsiu-Chi Cheng; Yu-Chin Tsai; Bor-Shyang Sheu (European Journal of Clinical Pharmacology, 2020)

Water quality assessment and pollution source apportionment using multi-statistic and APCS-MLR modeling techniques in Min River Basin, China - Han Zhang; Hongfei Li; Haoran Yu; Siqian Cheng (Environmental Science and Pollution Research, 2020)

Content and health risk assessment of heavy metals and polybrominated diphenyl ethers in fish from Songhua Lake (Jilin City), China - Mengnan Shen; Chunyu Kang; Tiehong Song; Hai Lu; Yuehong Wang; Bowen Yu; Ru Wang; Jie Cheng (Environmental Science and Pollution Research, 2020)

Predicting the spatiotemporal characteristics of flash droughts with downscaled CMIP5 models in the Jinghe River basin of China - Hui Ran; Jing Li; Zixiang Zhou; Cheng Zhang; Chengyan Tang; Yuyang Yu (Environmental Science and Pollution Research, 2020)

Differential distribution of and similar biochemical responses to different species of arsenic and antimony in Vetiveria zizanioides - Huang Yu; Xizhe Yan; Xiafei Zheng; Kui Xu; Qiuping Zhong; Tony Yang; Feifei Liu; Cheng Wang; Longfei Shu; Zhili He; Fanshu Xiao; Qingyun Yan (Environmental Geochemistry and Health, 2020)

Assimilation of exogenous cyanide cross talk in Oryza sativa L. to the key nodes in nitrogen metabolism - Cheng-Zhi Li; Li Yang; Yu-Juan Lin; Hua Zhang; Saeed Rad; Xiao-Zhang Yu (Ecotoxicology, 2020)

Identification and Characterization of the Nuclease Activity of the Extracellular Proteins from Salmonella enterica Serovar Typhimurium - Chengshui Liao; Mengke Zhang; Xiangchao Cheng; Qi Li; Fuchao Mao; Xiaoli Wang; Chuan Yu; Zuhua Yu; Yanyan Jia; Jing Li; Lei He; Chunjie Zhang; et al. (Current Microbiology, 2020)

Characterization of a Protease Hyper-Productive Mutant of Bacillus pumilus by Comparative Genomic and Transcriptomic Analysis - Yong-Cheng Liu; Lin-Li Han; Tian-Yu Chen; Yan-Bing Lu; Hong Feng (Current Microbiology, 2020)

Prevalence of Clonorchis sinensis infection in fish in South‐East Asia: A systematic review and meta‐analysis - Ying Zhang; Qing‐Long Gong; Qing‐Bo Lv; Yang‐Yuan Qiu; Yan‐Chun Wang; Hong‐Yu Qiu; Xin‐Rui Guo; Jun‐Feng Gao; Qiao‐Cheng Chang; Chun‐Ren Wang (Journal of Fish Diseases, 2020)
Clonorchis sinensis , an important fish‐borne zoonotic trematode, is widely distributed in South‐East Asia, especially in China. Infections from human and animal reservoir hosts occur due to the consumption of raw or undercooked fish with C. sinensis metacercariae. This study aimed to evaluate the prevalence of C. sinensis metacercariae in fish in South‐East Asia via systematic review and meta‐analysis. We searched PubMed, ScienceDirect, China National Knowledge Infrastructure, Wanfang and Chongqing VIP databases for studies published between 1976 and 2020 that are related to the prevalence of C. sinensis metacercariae in fish. Studies were screened with keywords based on inclusion and exclusion criteria. Seventy‐one eligible articles were identified, covering three countries: China, Korea and Vietnam. The pooled prevalence of C. sinensis metacercariae in fish from South‐East Asia was 30.5%, with 35.1% in China, 29.7% in Korea and 8.4% in Vietnam. In subgroup analyses of climate, season, water source and publication date, the highest prevalence was identified in the Dwb climate type (43.3%), summer (70.2%), river (34.5%) and pre‐2001 publications (38.9%), respectively. In comparison, the lowest prevalence was found in the Dfa climate type (14.5%), winter (19.5%), lake (8.0%) and post‐2001 publications (23.8%). Meta‐regression results indicated that country ( p = .009), the published time ( p = .035) and water source subgroups ( p = .003) may be the source of heterogeneity. Overall, our study indicates that a high prevalence of C. sinensis infections occurs in fish in China, Korea and Vietnam, illuminating a significant public health concern in these countries.

Isopimarane-type diterpenoids from Croton laevigatus - Man-Yu Li; Zheng-Zhi Han; Li-Fang Liu; Xiao-Zhen Wu; Wen-Jun Huang; Kai Wang; Fan Yang; Cheng-Shan Yuan (Natural Product Research, 2020)

Chemical constituents from Glehnia littoralis and their chemotaxonomic significance - Shouwen Zhang; Fang Cheng; Li Yang; Jinxiang Zeng; Fengyu Han; Xiuling Yu; Yuye Zhu; Guoyue Zhong; Junwei He (Natural Product Research, 2020)

Two new anthraquinone derivatives and one new triarylbenzophenone analog from Selaginella tamariscina - Rui Liu; Hui Zou; Zhen-Xing Zou; Fei Cheng; Xia Yu; Ping-Sheng Xu; Xiao-Min Li; Dai Li; Kang-Ping Xu; Gui-Shan Tan (Natural Product Research, 2020)

Cerebral Organoids Repair Ischemic Stroke Brain Injury - Shu-Na Wang; Zhi Wang; Tian-Ying Xu; Ming-He Cheng; Wen-Lin Li; Chao-Yu Miao (Translational Stroke Research, 2020)
Stroke is the second leading cause of death and main cause of disability worldwide, but with few effective therapies. Although stem cell-based therapy has been proposed as an exciting regenerative medicine strategy for brain injury, there are limitations. The developed cerebral organoids (COs) represent a promising transplantation source for stroke that remains to be answered. Here, we transplanted COs at 55 days and explored the feasibility in the rat middle cerebral artery occlusion (MCAO) model of stroke. COs transplantation at 6 h or even 24 h after MCAO significantly reduces brain infarct volume and improves neurological motor function. Transplanted COs show the potential of multilineage differentiation to mimic in vivo cortical development, support motor cortex region-specific reconstruction, form neurotransmitter-related neurons, and achieve synaptic connection with host brain via in situ differentiation and cell replacement in stroke. Cells from transplanted COs show extensive migration into different brain regions along corpus callosum. The mechanisms underlying COs transplantation therapy are also associated with enhanced neurogenesis, synaptic reconstruction, axonal regeneration and angiogenesis, and decreased neural apoptosis with more survival neurons after stroke. Moreover, COs transplantation promotes predominantly exogenous neurogenesis in the transplantation periphery of ipsilateral cortex and predominantly endogenous neurogenesis in the hippocampus and subventricular zone. Together, we demonstrate the efficacy and underlying mechanisms of COs transplantation in stroke. This preliminary but promising study provides first-hand preclinical evidence for COs transplantation as a potential and effective intervention for stroke treatment.

The completed macronuclear genome of a model ciliate Tetrahymena thermophila and its application in genome scrambling and copy number analyses - Yalan Sheng; Lili Duan; Ting Cheng; Yu Qiao; Naomi A. Stover; Shan Gao (Science China Life Sciences, 2020)

Liquiritin inhibits proliferation and induces apoptosis in HepG2 hepatocellular carcinoma cells via the ROS-mediated MAPK/AKT/NF-κB signaling pathway - Jia-Ru Wang; Tian-Zhu Li; Cheng Wang; Shu-Mei Li; Ying-Hua Luo; Xian-Ji Piao; Yu-Chao Feng; Yi Zhang; Wan-Ting Xu; Yu Zhang; Tong Zhang; Shi-Nong Wang; et al. (Naunyn-Schmiedeberg's Archives of Pharmacology, 2020)

Sulfur isotope and trace element compositions of pyrite determined by NanoSIMS and LA-ICP-MS: new constraints on the genesis of the Shuiyindong Carlin-like gold deposit in SW China - Jin-xiang Li; Rui-zhong Hu; Cheng-hai Zhao; Jing-jing Zhu; Yong Huang; Wei Gao; Jin-wei Li; Yu-zhou Zhuo (Mineralium Deposita, 2020)

Knockdown of Amphiregulin Triggers Doxorubicin-Induced Autophagic and Apoptotic Death by Regulating Endoplasmic Reticulum Stress in Glioblastoma Cells - I-Neng Lee; Jen-Tsung Yang; Ming-Ju Hsieh; Cheng Huang; Hsiu-Chen Huang; Yu-Ju Ku; Yu-Ping Wu; Kuan-Chieh Huang; Jui-Chieh Chen (Journal of Molecular Neuroscience, 2020)

LncRNA ADAMTS9-AS1, as prognostic marker, promotes cell proliferation and EMT in colorectal cancer - Wanjing Chen; Qian Tu; Liang Yu; Yanyan Xu; Gang Yu; Benli Jia; Yunsheng Cheng; Yong Wang (Human Cell, 2020)

Matriptase and prostasin proteolytic activities are differentially regulated in normal and wounded skin - Shun-Cheng Chang; Chien-Ping Chiang; Chih-Hsin Lai; Po-Wen A. Du; Yu-Sin Hung; Yu-Hsuan Chen; Hui-Yu Yang; Hao-Yu Fang; Shiao-Pieng Lee; Hung-Jen Tang; Jehng-Kang Wang; Michael D. Johnson; et al. (Human Cell, 2020)

Short-term effect of extreme air temperature on hospital emergency room visits for cardiovascular diseases from 2009 to 2012 in Beijing, China - Yuxia Ma; Haoran Jiao; Yifan Zhang; Fengliu Feng; Bowen Cheng; Bingji Ma; Zhiang Yu (Environmental Science and Pollution Research, 2020)

Modification-bioremediation of copper, lead, and cadmium-contaminated soil by combined ryegrass (Lolium multiflorum Lam.) and Pseudomonas aeruginosa treatment - Guang-yu Shi; Ying-jia Yan; Zhi-qiang Yu; Lu Zhang; Yuan-yuan Cheng; Wei-lin Shi (Environmental Science and Pollution Research, 2020)

Rejection of parasitic eggs by Yellow-bellied Prinias: importance of egg spot location - Longwu Wang; Yu-Cheng Hsu; Wei Liang (Journal of Ornithology, 2020)

Power-Law Scaling of Turbulence Cospectra for the Stably Stratified Atmospheric Boundary Layer - Yu Cheng; Qi Li; Andrey Grachev; Stefania Argentini; Harindra J. S. Fernando; Pierre Gentine (Boundary-Layer Meteorology, 2020)

Climate Variability Patterns and Their Ecological Effects on Ecosystems in the Northwestern North Pacific - Shuyang Ma; Yongjun Tian; Jianchao Li; Haiqing Yu; Jiahua Cheng; Peng Sun; Caihong Fu; Yang Liu; Yoshiro Watanabe (Frontiers in Marine Science, 2020)

Archaeobotanical evidence reveals the human–environment interactions during the 9th–13th centuries at Turpan, Xinjiang on the ancient Silk Road - Yi-Feng Yao; Xia Wang; Wu Guo; Hong-En Jiang; Min Li; David K. Ferguson; Yu-Fei Wang; Cheng-Sen Li (Vegetation History and Archaeobotany, 2020)

Annual 30-m land use/land cover maps of China for 1980–2015 from the integration of AVHRR, MODIS and Landsat data using the BFAST algorithm - Yidi Xu; Le Yu; Dailiang Peng; Jiyao Zhao; Yuqi Cheng; Xiaoxuan Liu; Wei Li; Ran Meng; Xinliang Xu; Peng Gong (Science China Earth Sciences, 2020)

Combining genome composition and differential gene expression analyses reveals that SmPGH1 contributes to bacterial wilt resistance in somatic hybrids - Haibo Wang; Zhengnan Cheng; Bingsen Wang; Jianke Dong; Wenxuan Ye; Yan Yu; Ting Liu; Xingkui Cai; Botao Song; Jun Liu (Plant Cell Reports, 2020)

Alpinia oxyphylla–Schisandra chinensis Herb Pair Alleviates Amyloid-β Induced Cognitive Deficits via PI3K/Akt/Gsk-3β/CREB Pathway - Yu Qi; Huiting Jing; Xinhui Cheng; Tingxu Yan; Feng Xiao; Bo Wu; Kaishun Bi; Ying Jia (NeuroMolecular Medicine, 2020)

Correction to: Long non-coding RNA H19 promotes osteogenic differentiation of renal interstitial fibroblasts through Wnt-β-catenin pathway - Zewu Zhu; Yu Cui; Fang Huang; Huimin Zeng; Weiping Xia; Feng Zeng; Cheng He; Jinbo Chen; Zhiyong Chen; Hequn Chen; Yang Li (Molecular and Cellular Biochemistry, 2020)

Improving Fruit Coloration, Quality Attributes, and Phenolics Content in ‘Rainier’ and ‘Bing’ Cherries by Gibberellic Acid Combined with Homobrassinolide - Meng Li; Shunchang Cheng; Yan Wang; Yu Dong (Journal of Plant Growth Regulation, 2020)

Energy consumption, environmental pollution, and technological innovation efficiency: taking industrial enterprises in China as empirical analysis object - Cheng-lin Miao; Xiao-na Meng; Meng-meng Duan; Xin-yu Wu (Environmental Science and Pollution Research, 2020)

Phylogenetic analysis of the whole genome sequence of a dog lineage rabies virus detected from cattle in eastern China, 2019 - Kaihui Cheng; Huimeng Chu; Yachu Ren; Xiaoli Xie; Zhijun Yu; Hongjun Yang (Brazilian Journal of Microbiology, 2020)

Key Role of Pro-inflammatory Cytokines in the Toxic Effect of Fluoride on Hepa1-6 Cells - Yan Zhang; Bian-hua Zhou; Pan-pan Tan; Yu Chen; Cheng-yi Miao; Hong-wei Wang (Biological Trace Element Research, 2020)

Ecological analysis of gamasid mites on the body surface of Norway rats (Rattus norvegicus) in Yunnan Province, Southwest China - Zhe Liu; Xian-Guo Guo; Rong Fan; Cheng-Fu Zhao; Ke-Yu Mao; Zhi-Wei Zhang; Yue Zhao (Biologia, 2020)

Genesis of the Linghu Au deposit in Xiaoqinling Region, Henan province, China: Constraints from fluid inclusions and isotope systematics - Wei Zeng; Zhi-gao Wang; Duo Wan; Feng-yue Sun; Cheng-dong Li; Reng-an Yu; Jia-ying Wang; Jian-chang Xu (Arabian Journal of Geosciences, 2020)

Comparing Subsurface Seasonal Deoxygenation and Acidification in the Yellow Sea and Northern East China Sea Along the North-to-South Latitude Gradient - Tian-qi Xiong; Qin-sheng Wei; Wei-dong Zhai; Cheng-long Li; Song-yin Wang; Yi-xing Zhang; Shuo-jiang Liu; Si-qing Yu (Frontiers in Marine Science, 2020)

Power Prediction of Wind Farms via a Simplified Actuator Disk Model - Yen-Cheng Chiang; Yu-Cheng Hsu; Shiu-Wu Chau (Journal of Marine Science and Engineering, 2020)
This paper aims to demonstrate a simplified nonlinear wake model that fills the technical gap between the low-cost and less-accurate linear formulation and the high-cost and high-accuracy large eddy simulation, to offer a suitable balance between the prediction accuracy and the computational cost, and also to establish a robust approach for long-term wind farm power prediction. A simplified actuator disk model based on the momentum theory is proposed to predict the wake interaction among wind turbines along with their power output. The three-dimensional flow field of a wind farm is described by the steady continuity and momentum equation coupled with a k-ε turbulence model, where the body force representing the aerodynamic impact of the rotor blade on the airflow is uniformly distributed in the Cartesian cells within the actuator disk. The characteristic wind conditions identified from the data of the supervisory control and data acquisition (SCADA) system were employed to build the power matrix of these typical wind conditions for reducing the computation demands to estimate the yearly power production. The proposed model was favorably validated with the offshore measurement of Horns Rev wind farm, and three Taiwanese onshore wind farms were forecasted for their yearly capacity factors with an average error less than 5%, where the required computational cost is estimated about two orders of magnitude smaller than that of the large eddy simulation. However, the proposed model fails to pronouncedly reproduce the individual power difference among wind turbines in the investigated wind farm due to its time-averaging nature.

Relationship between the Altyn Tagh strike-slip fault and the Qaidam Basin：New insights from superposed buckle folding in Hongsanhan - Wei Du; Daowei Zhang; Xiangjiang Yu; Xiang Cheng; Zhendong Wang; Qing Bian; Zhaojie Guo (International Geology Review, 2020)