Recycling of ferronickel slag tailing in cementitious materials: Activation and performance - Lin Chi; Shuang Lu; Zhenming Li; Chendong Huang; Hui Jiang; Bin Peng (Science of The Total Environment, 2023)

Ambient relative humidity-dependent obstructive sleep apnea severity in cold season: A case-control study - Kuan-Jen Bai; Wen-Te Liu; Yuan-Chien Lin; Yansu He; Yueh-Lun Lee; Dean Wu; Ta-Yuan Chang; Li-Te Chang; Chun-Yeh Lai; Cheng-Yu Tsai; Kian Fan Chung; Kin-Fai Ho; et al. (Science of The Total Environment, 2023)

Ecological risk assessment and corrective actions for dioxin-polluted sediment in a chemical plant's brine water storage pond - Chi-Wei Huang; Wen-Yen Huang; Chitsan Lin; Yi-Lin Li; Tsung-Po Huang; Xuan-Thanh Bui; Huu Hao Ngo (Science of The Total Environment, 2023)

Spatial allocation of LID practices with a water footprint approach - Wen-Kai Chuang; Zih-Ee Lin; Tzu-Chi Lin; Shang-Lien Lo; Chia-Lin Chang; Pei-Te Chiueh (Science of The Total Environment, 2023)

Seasonal influence on pollution index and risk of multiple compositions of microplastics in an urban river - Chi-Wei Huang; Yi-Lin Li; Chitsan Lin; Xuan-Thanh Bui; Thi-Dieu-Hien Vo; Huu Hao Ngo (Science of The Total Environment, 2023)

Enhanced sulfolane-contaminated groundwater degradation and power generation by a mini tubular microbial fuel cell/electro-Fenton combined system - Shu-Hui Liu; Yen-Ni Tsai; Chiaying Chen; Chi-Wen Lin; Ting-Jun Zhu (Process Safety and Environmental Protection, 2023)

Promoting removal of copper from sediment and production of bioelectricity by sediment microbial fuel cells using tea extracts - Shu-Hui Liu; Chu-Yuan Yang; Chi-Wen Lin; Ting-Jun Zhu (Journal of Water Process Engineering, 2023)

A framework for the sustainable risk assessment of in-river hydraulic structures: A case study of Taiwan’s Daan River - Dong-Sin Shih; Shang-Shu Shih; Shaohua Marko Hsu; Shih-Yuan Lin; Yiching Lin; Chi-Tung Hung; Kai Wang (Journal of Hydrology, 2023)

An assessment of rainfall kinetic energy functional relationships with GPM DPR - Jayalakshmi Janapati; Balaji Kumar Seela; Pay-Liam Lin; Chen-Hau Lan; Chuan-Chi Tu; Utpal Kumar; Mu-Qun Huang (Journal of Hydrology, 2023)

Photothermal and Concus Finn capillary assisted superhydrophobic fibrous network enabling instant viscous oil transport for crude oil cleanup - Ting Dong; Yanhui Liu; Na Tian; Yuanming Zhang; Guangting Han; Fudi Peng; Ching-Wen Lou; Shan Chi; Yanming Liu; Cui Liu; Jia-Horng Lin (Journal of Hazardous Materials, 2023)

Solar photodegradation of the UV filter benzotriazole in the presence of persulfate - Shih-Chieh Lai; Hank Hui-Hsiang Lin; Jheng-Sian Yang; Ming-Chi Hsieh; Angela Yu-Chen Lin (Journal of Environmental Chemical Engineering, 2023)

Generating Sentinel-2 all-band 10-m data by sharpening 20/60-m bands: A hierarchical fusion network - Jingan Wu; Liupeng Lin; Chi Zhang; Tongwen Li; Xiao Cheng; Fang Nan (ISPRS Journal of Photogrammetry and Remote Sensing, 2023)

Universal correlation for falling film evaporation on a horizontal plain tube - Hao-Yu Lin; Muneeshwaran M; Cheng-Min Yang; Kashif Nawaz; Chi-Chuan Wang (International Journal of Refrigeration, 2023)

On the occurrence of low concentration hyperpycnal river plumes in a small mountainous river-canyon system - Sheng-De Tsai; Yu-Chi Lin; Andhy Romdani; Jia-Lin Chen; Ray T. Hsu; James T. Liu (Continental Shelf Research, 2023)

Typhoon-induced destruction and reconstruction of the coastal current system on the inner shelf of East China Sea - Wenqi Chi; Fangfang Shu; Yuting Lin; Yunhai Li; Fusheng Luo; Jia He; Zhijie Chen; Xiaochun Zou; Binxin Zheng (Continental Shelf Research, 2023)

Source-specific health risk analysis on atmospheric hazardous volatile organic compounds (HVOCs) in Nanjing, East China - Yu-Chi Lin; Zi-Jin Zhang; Meng-Yao Cao; Mei-Yi Fan; Ahsan Mozaffar; Ming-Yuan Yu; Feng Xie; Yan-Lin Zhang (Atmospheric Environment, 2023)

Analyzing landslide-induced debris flow and flow-bridge interaction by using a hybrid model of depth-averaged model and discrete element method - Wen-Jie Shiu; Ching-Fang Lee; Chia-Chi Chiu; Meng-Chia Weng; Che-Ming Yang; Wei-An Chao; Chun-Yuan Liu; Cheng-Han Lin; Wei-Kai Huang (Landslides, 2023)

Automatic diagnosis of late-life depression by 3D convolutional neural networks and cross-sample Entropy analysis from resting-state fMRI - Chemin Lin; Shwu-Hua Lee; Chih-Mao Huang; Guan-Yen Chen; Wei Chang; Ho-Ling Liu; Shu-Hang Ng; Tatia Mei-Chun Lee; Shun-Chi Wu (Brain Imaging and Behavior, 2023)
Resting-state fMRI has been widely used in investigating the pathophysiology of late-life depression (LLD). Unlike the conventional linear approach, cross-sample entropy (CSE) analysis shows the nonlinear property in fMRI signals between brain regions. Moreover, recent advances in deep learning, such as convolutional neural networks (CNNs), provide a timely application for understanding LLD. Accurate and prompt diagnosis is essential in LLD; hence, this study aimed to combine CNN and CSE analysis to discriminate LLD patients and non-depressed comparison older adults based on brain resting-state fMRI signals. Seventy-seven older adults, including 49 patients and 28 comparison older adults, were included for fMRI scans. Three-dimensional CSEs with volumes corresponding to 90 seed regions of interest of each participant were developed and fed into models for disease classification and depression severity prediction. We obtained a diagnostic accuracy > 85% in the superior frontal gyrus (left dorsolateral and right orbital parts), left insula, and right middle occipital gyrus. With a mean root-mean-square error (RMSE) of 2.41, three separate models were required to predict depressive symptoms in the severe, moderate, and mild depression groups. The CSE volumes in the left inferior parietal lobule, left parahippocampal gyrus, and left postcentral gyrus performed best in each respective model. Combined complexity analysis and deep learning algorithms can classify patients with LLD from comparison older adults and predict symptom severity based on fMRI data. Such application can be utilized in precision medicine for disease detection and symptom monitoring in LLD.

Intraoperative Detection of Surgical Gauze Using Deep Convolutional Neural Network - Shuo-Lun Lai; Chi-Sheng Chen; Been-Ren Lin; Ruey-Feng Chang (Annals of Biomedical Engineering, 2023)

Fixing sulfur dioxide by feeding calcine oxide into the rotary volatilization kiln in zinc smelting plant - Wei Weng; Wenze Zhang; Hongfu Lin; Xiaopeng Chi; Shuiping Zhong (Environmental Science and Pollution Research, 2023)

Editorial: Oceanographic processes linking nearshore, continental shelf, and shelf break - Feng-Hsun Chang; Yun-Chi Lin; Kuo-Ping Chiang; Ya-Han Nien; Chih-hao Hsieh; Wei-Jen Chen; Chin-Chang Hung; Toru Kobari; Hiroaki Saito; William Savidge (Frontiers in Marine Science, 2023)

Two new chromones and a new coumarin from the fruit of Cnidium monnieri (L.) Cusson - Hui-Chi Huang; Chun-Hsiang Lin; Ching-Chuan Kuo; Ming-Der Wu; Ming-Jen Cheng; Jih-Jung Chen; Che-Yi Chao; Guan-Jhong Huang; Yueh-Hsiung Kuo (Natural Product Research, 2023)

Chromatin modifiers: A new class of pollutants with potential epigenetic effects revealed by in vitro assays and transcriptomic analyses - Chi Tim Leung; Yi Yang; Ting Fung Chan; Xiao Lin; Alice Sze Tsai Wong; Wing Yee Lui; Karen Wing Yee Yuen; Richard Yuen Chong Kong; Keng Po Lai; Rudolf Shiu Sun Wu (Toxicology, 2023)

Seasonal variations of low molecular alkyl amines in PM2.5 in a North China Plain industrial city: Importance of secondary formation and combustion emissions - Xiao-Ying Yang; Fang Cao; Mei-Yi Fan; Yu-Chi Lin; Feng Xie; Yan-Lin Zhang (Science of The Total Environment, 2023)

Continuous inactivation of human adenoviruses in water by a novel g-C3N4/WO3/biochar memory photocatalyst under light-dark cycles - Chi Zhang; Wei Xiong; Yi Li; Li Lin; Xinyi Zhou; Xinyan Xiong (Journal of Hazardous Materials, 2023)

Microbiome reengineering by four environmental factors for the rapid biodegradation of trichloroethylene - Yu-Hsuan Cheng; Shu-Chi Chang; Yan-Lin Lai; Chung-Chi Hu (Journal of Environmental Management, 2023)

Comparison of polycyclic aromatic hydrocarbon accumulation in crab tissues with the ambient marine particles from shallow hydrothermal vents, northeast Taiwan - Fang-Jing Deborah Lee; Jiang-Shiou Hwang; Jing-O Cheng; Huei-Ting Lin; Fung-Chi Ko (Environmental Research, 2023)

Role of chicken fat waste and hydrogen energy ratio as the potential alternate fuel with nano-additives: Insights into resources and atmospheric remediation process - Lin Yi-Chia; Manigandan Sekar; Arunachalam Chinnathambi; Omaima Nasif; Beata Gavurová; G.K. Jhanani; Kathirvel Brindhadevi; Nguyen Thuy Lan Chi (Environmental Research, 2023)

Using cluster algorithms with a machine learning technique and PMF models to quantify local-specific origins of PM2.5 and associated metals in Taiwan - Chin-Yu Hsu; Jhy-Charm Soo; Sheng-Lun Lin; Chih-Da Wu; Kai Hsien Chi; Wen-Chang Hsu; Chun-Chieh Tseng; Yu-Cheng Chen (Environmental Pollution, 2023)

Realizing the bifunctional electrocatalysis via local charge rearrangement of α-CrOOH-modulated Co@CoMoOx for overall water splitting - Suh-Ciuan Lim; Chao-Lung Chiang; Chun-Kuo Peng; Wen-Bin Wu; Yu-Chang Lin; Yu-Ru Lin; Chi-Liang Chen; Yan-Gu Lin (Chemical Engineering Journal, 2023)

A full range of defect passivation strategy targeting efficient and stable planar perovskite solar cells - Yansen Sun; Shuo Yang; Zhenyu Pang; Haipeng Jiang; Shaohua Chi; Xiaoxu Sun; Lin Fan; Fengyou Wang; Xiaoyan Liu; Maobin Wei; Lili Yang; Jinghai Yang (Chemical Engineering Journal, 2023)

Intelligent films of marine polysaccharides and purple cauliflower extract for food packaging and spoilage monitoring - Han-Lun Huang; I-Lin Tsai; Chi Lin; Yu-Hao Hang; Yi-Cheng Ho; Min-Lang Tsai; Fwu-Long Mi (Carbohydrate Polymers, 2023)

Dimerization induces bimodality in protein number distributions - Ming-Yang Ling; Lin-Jie Chiu; Ching-Chu Hsieh; Che-Chi Shu (BioSystems, 2023)

Quantification of fossil and non-fossil sources to the reduction of carbonaceous aerosols in the Yangtze River Delta, China: Insights from radiocarbon analysis during 2014–2019 - Mingyuan Yu; Yan-Lin Zhang; Tian Xie; Wenhuai Song; Yu-Chi Lin; Yuxian Zhang; Fang Cao; Chi Yang; Sӧnke Szidat (Atmospheric Environment, 2023)

Effects of dissolved oxygen on intestinal bacterial community and immunity of Atlantic salmon Salmo salar - Shihong Xu; Yanfeng Wang; Caixia Gao; Sarath Babu V; Jun Li; Qinghua Liu; Zhizhong Xiao; Yingxuan Xu; Chunyan Zhao; Li Lin; Liang Chi (Journal of Oceanology and Limnology, 2023)

Associations between gastrointestinal infection and urinary phthalate metabolite concentrations in US children and adolescents from NHANES 2005–2016 - Chuang Zhang; Weirui Ren; Chi Sun; Lin Liu; Meng Li; Wenbo Wang; Yanbin Fang; Lin Liu; Xiaofeng Yang; Xiangjian Zhang; Suolin Li (Environmental Science and Pollution Research, 2023)

Control measure implications of COVID-19 infection in healthcare facilities reconsidered from human physiological and engineering aspects - Ying-Fei Yang; Yi-Jun Lin; Shu-Han You; Tien-Hsuan Lu; Chi-Yun Chen; Wei-Min Wang; Chung-Min Liao (Environmental Science and Pollution Research, 2022)

Mesenchymal Stem Cell Secreted-Extracellular Vesicles are Involved in Chondrocyte Production and Reduce Adipogenesis during Stem Cell Differentiation - Yu-Chen Tsai; Tai-Shan Cheng; Hsiu-Jung Liao; Ming-Hsi Chuang; Hui-Ting Chen; Chun-Hung Chen; Kai-Ling Zhang; Chih-Hung Chang; Po-Cheng Lin; Chi-Ying F. Huang (Tissue Engineering and Regenerative Medicine, 2022)
Background: Extracellular vesicles (EVs) are derived from internal cellular compartments, and have potential as a diagnostic and therapeutic tool in degenerative disease associated with aging. Mesenchymal stem cells (MSCs) have become a promising tool for functional EVs production. This study investigated the efficacy of EVs and its effect on differentiation capacity. Methods: The characteristics of MSCs were evaluated by flow cytometry and stem cell differentiation analysis, and a production mode of functional EVs was scaled from MSCs. The concentration and size of EVs were quantitated by Nanoparticle Tracking Analysis (NTA). Western blot analysis was used to assess the protein expression of exosome-specific markers. The effects of MSC-derived EVs were assessed by chondrogenic and adipogenic differentiation analyses and histological observation. Results: The range of the particle size of adipose-derived stem cells (ADSCs)- and Wharton’s jelly -MSCs-derived EVs were from 130 to 150 nm as measured by NTA, which showed positive expression of exosomal markers. The chondrogenic induction ability was weakened in the absence of EVs in vitro . Interestingly, after EV administration, type II collagen, a major component in the cartilage extracellular matrix, was upregulated compared to the EV-free condition. Moreover, EVs decreased the lipid accumulation rate during adipogenic induction. Conclusion: The results indicated that the production model could facilitate production of effective EVs and further demonstrated the role of MSC-derived EVs in cell differentiation. MSC-derived EVs could be successfully used in cell-free therapy to guide chondrogenic differentiation of ADSC for future clinical applications in cartilage regeneration.

In silico prediction of parkinsonian motor deficits-related neurotoxicants based on the adverse outcome pathway concept - Hung-Lin Kan; Chun-Wei Tung; Shao-En Chang; Ying-Chi Lin (Archives of Toxicology, 2022)

Coupling Relationship of Geomorphic Evolution and Marine Hydrodynamics in the Stage-Specific Development of Urban Bays: A Modelling Case Study in Quanzhou Bay (1954–2017), China - Xianbiao Xiao; Yunhai Li; Junjian Tang; Fusheng Luo; Fangfang Shu; Liang Wang; Jia He; Xiaochun Zou; Wenqi Chi; Yuting Lin; Binxin Zheng (Journal of Marine Science and Engineering, 2022)
With the development of social economy and human activities, the geomorphology and hydrodynamic conditions of coasts have been dramatically changed, causing serious environmental pollution and resource depletion. Taking Quanzhou Bay as an example, this study combined geomorphologic change with a hydrodynamic model to simulate the change in tidal currents in different periods. The results show a change in the coastline was the main cause of hydrodynamic change during the industrialization reform. During the past 70 years, the tidal prism decreased year by year, and the average velocity of the tidal current in the channel decreased by 33.7% and 30.8% at flood and ebb tide, respectively. In the early stages of industrialization, reclamation land was used in a single way. The tidal prism decreased by 22.2% and 29.8% in the spring and neap tide, respectively. In the middle and later stages, the tidal current velocity increased, and reclamation land was used in a variety of ways. In modern society, the reclamation land-use type was unitary. Based on this research, we show the influence of human activities on the evolution of the bay’s geomorphology and provide suggestions for the management of the bay.

An overview of cotton and polyester, and their blended waste textile valorisation to value-added products: A circular economy approach – research trends, opportunities and challenges - Karpagam Subramanian; Manas Kumar Sarkar; Huaimin Wang; Zi-Hao Qin; Shauhrat S. Chopra; Mushan Jin; Vinod Kumar; Chao Chen; Chi-Wing Tsang; Carol Sze Ki Lin (Critical Reviews in Environmental Science and Technology, 2022)

7,8-Dihydroxyflavone attenuates the virulence of Staphylococcus aureus by inhibiting alpha-hemolysin - Nan Bian; Xiangqian Chen; Xinran Ren; Zishu Yu; Mengli Jin; Xiaoyu Chen; Chang Liu; Yanhe Luan; Lin Wei; Ying Chen; Wu Song; Yicheng Zhao; et al. (World Journal of Microbiology and Biotechnology, 2022)

ACC deaminase-encoding Pseudomonas putida arrests seed germination: an alternative strategy for grass and weed control - Di Zhou; Jia-Ling Zhao; Rui Wang; Hai-Lin Wang; Daniela D. Herrera-Balandrano; Tang-Min Chen; Xiao-Feng Lu; Xu-Chu Duan; Mahdi Shahriar; Xin-Chi Shi; Pedro Laborda; Su-Yan Wang (Plant and Soil, 2022)

Evaluation of the Potential of the Hard Clam (Meretrix meretrix) Shell Which Can Be Used as the Bioindicator for Heavy Metal Accumulation - Yen-Ting Lin; Fang-Chi Chang; Ming-Tsung Chung; Ze-Kai Li; Chang-Chuan Chan; Ying-Sheng Huang; Kuo-Fang Huang; Yu-San Han (Fishes, 2022)
Clams, Meretrix meretrix, were one of the favorite aquatic products in Taiwan and the world. It was reported that the water pollutants such as heavy metals and chemicals might accumulate in the clam body and shell through filter-feeding behavior. Thus, the bivalves could be used as bioindicators in the aquatic environment. The present study analyzed 20 trace elements, Mg, Sr, Li, Cd, Ba, Mn, Al, U, Ti, Pb, Nd, B, S, Zn, Fe, P, Na, K, Cu, and Ni, in the shells of the clams collected from the wild coastal area and cultured ponds to evaluate which elements have the potential to be biomarkers. The concentrations of 20 elements were detected by Solution-Based Inductively Coupled Plasma Mass Spectrometry (SB-ICPMS). Among them, Cd, Al, U, Ti, Nd, S, and K were below the detection limit. The remaining elements were analyzed for accumulation. The levels of Zn, Fe, and Ni possess high variation in an identical environment; so, a PCA was conducted without these three elements to reduce noise. The PCA result proved that the clam could absorb specific trace elements from the habitat. After a period of time, the contents of the absorption in the shells of the clams living in an identical environment became more similar. The analyzed element, Pb, was not found with a special difference in this study. The levels of Na, Sr, Mg, B, Mn, P, Ba, Li, and Cu reflected different sampling sites, which suggested that these elements in the species M. meretrix had the potential to be used as biomarkers for assessing heavy metal accumulation in the environment.

Interaction between seawater carbon dioxide dynamics and stratification in shallow coastal waters: A preliminary study based on a weekly validated three-dimensional ecological model - Bing Xiong; Shinichiro Yano; Katsuaki Komai; Naoki Saito; Hiroto Komori; Baixin Chi; Lin Hao; Keisuke Nakayama (Frontiers in Marine Science, 2022)
Shallow coastal waters (SCWs) have attracted wide attention in recent years due to their strong carbon sequestration capacity. However, the complex carbon dioxide (CO 2 ) dynamics in the water column makes it difficult to estimate the air–water CO 2 fluxes (F CO2 ) accurately. We developed a numerical model of CO 2 dynamics in water based on field measurements for a typical stratified semi-enclosed shallow bay: the Yatsushiro Sea, Japan. The developed model showed an excellent ability to reproduce the stratification and CO 2 dynamics of the Yatsushiro Sea. Through numerical model simulations, we analyzed the annual CO 2 dynamics in the Yatsushiro Sea in 2018. The results show that the effect of stratification on the CO 2 dynamics in seawater varies greatly depending on the distance from the estuary and the period. In the estuarine region, stratification manifests itself throughout the year by promoting the maintenance of a high partial pressure of CO 2 (pCO 2 ) in surface waters, resulting in surface pCO 2 being higher than atmospheric pCO 2 for up to 40 days during the flood period (average surface pCO 2 of 539.94 µatm). In contrast, in areas farther from the estuary, stratification mainly acts to promote the maintenance of high pCO 2 in surface waters during periods of high freshwater influence. Then changes to a lower surface pCO 2 before the freshwater influence leads towards complete dissipation. Finally, we estimated the F CO2 of the Yatsushiro Sea in 2018, and the results showed that the Yatsushiro Sea was a sink area for atmospheric CO 2 in 2018 (−1.70 mmol/m 2 /day).

Plasma Matrix Metalloproeteinase-9 Is Associated with Seizure and Angioarchitecture Changes in Brain Arteriovenous Malformations - Yo-Tsen Liu; Cheng-Chia Lee; Chun-Fu Lin; Hsiu-Mei Wu; Wan-Yuo Guo; Huai-Che Yang; Feng-Chi Chang; Kang-Du Liou; Chung-Jung Lin (Molecular Neurobiology, 2022)

Corrigendum: Effects of dietary glycerol monolaurate on growth, antioxidant capacity and lipid metabolism in cage-farmed pompano (Trachinotus ovatus) juveniles - Huaxing Lin; Beiping Tan; Qihui Yang; Shuyan Chi; Hongjie Wei; Yuancai Wu; Gyan Watson Ray; Mpwaga Alatwinusa Yohana (Frontiers in Marine Science, 2022)

Effects of fuel injection system and exhaust gas catalytic treatments on PAH emissions from motorcycles - Sheng-Lun Lin; Hongjie Zhang; Lin-Chi Wang; Yen-Yi Lee; Chien-Er Huang (Environmental Science and Pollution Research, 2022)

Evaluation of the impact of crop residue on fractional vegetation cover estimation by vegetation indices over conservation tillage cropland: a simulation study - Zewen Dai; Yanling Ding; Chi Xu; Yunchao Chen; Lin Liu (International Journal of Remote Sensing, 2022)

Stochastic analysis of the variability of groundwater flow fields in heterogeneous confined aquifers of variable thickness - Ching-Min Chang; Chuen-Fa Ni; We-Ci Li; Chi-Ping Lin; I-Hsian Lee (Stochastic Environmental Research and Risk Assessment, 2022)

Biomechanical Analysis of Mandibular Implant-Assisted Removable Partial Denture with Distal Extension - Yung-Chung Chen; Chi-Lun Lin; Chen-Han Yu; Hung-Chih Chang; Yang-Ming Lin; Jia-Wei Lin (Journal of Medical and Biological Engineering, 2022)

Effect of application mode (capping and amendment) on the control of cadmium release from sediment by apatite/calcite mixture and its phosphorus release risk - Chi Liu; Jianwei Lin; Zhibin Zhang; Yanhui Zhan; Dazhu Hu (Environmental Science and Pollution Research, 2022)

Association of cognitive impairment and reduced cortical thickness in prefrontal cortex and anterior cingulate cortex with treatment-resistant depression - Mu-Hong Chen; Wan-Chen Chang; Pei-Chi Tu; Wei-Chen Lin; Cheng-Ta Li; Wen-Sheng Huang; Ya-Mei Bai; Shih-Jen Tsai; Tung-Ping Su (Brain Imaging and Behavior, 2022)

Assessing the effect of probiotics on tilapia lake virus‐infected tilapia: Transmission and immune response - Ying‐Fei Yang; Jidapa Yamkasem; Win Surachetpong; Yi‐Jun Lin; Shu‐Han You; Tien‐Hsuan Lu; Chi‐Yun Chen; Wei‐Min Wang; Chung‐Min Liao (Journal of Fish Diseases, 2022)
Probiotics have been used to alleviate disease transmission in aquaculture. However, there are limited studies on probiotic use in modulating tilapia lake virus (TiLV). We assessed commercially available probiotic supplements used in TiLV‐infected tilapia and performed mortality and cohabitation assays. We developed a mechanistic approach to predict dose–response interactions of probiotic effects on mortality and immune gene response. We used a susceptible–infected–mortality disease model to assess key epidemiological parameters such as transmission rate and basic reproduction number ( R 0 ) based on our viral load dynamic data. We found that the most marked benefits of probiotics are significantly associated with immune system enhancements (~30%) and reductions in disease transmission (~80%) and R 0 (~70%) in tilapia populations, resulting in a higher tolerance of farming densities (~400 fold) in aquaculture. These findings provide early insights as to how probiotic use‐related factors may influence TiLV transmission and the immune responses in TiLV‐infected tilapia. Our study facilitates understanding the mode of action of probiotics in disease containment and predicting better probiotic dosages in diet and supplements to achieve the optimal culturing conditions. Overall, our analysis assures that further study of rationally designed and targeted probiotics, or mechanistic modelling is warranted on the basis of promising early data of this approach.

Isolation and identification of two new sargentodoxosides from Sargentodoxa cuneata and their agonistic effects against FXR - Wen Zhang; Cheng-Peng Sun; Yu-Lin Peng; Wen-Yu Zhao; Zheng-Yue Wang; Jing Ning; Xia Lv; Zhen-Long Yu; Shuang Zhou; Wei Peng; Bang-Jiang Fang; Xiao-Chi Ma (Natural Product Research, 2022)

The Spatial Variation in Chlorophyte Community Composition From Coastal to Offshore Waters in a Subtropical Continental Shelf System - Yun-Chi Lin; Chien-Pang Chin; Wei-Ting Chen; Ching-Ting Huang; Gwo-Ching Gong; Kuo-Ping Chiang; Xin-Bei Chen (Frontiers in Marine Science, 2022)
Globally, the continental shelf occupies less than 10% of the total sea surface, but supports substantial primary production and fisheries. Photosynthetic picoeukaryotes (PPE) are important primary producers in marine ecosystems, and chlorophytes make a significant contribution to PPE abundance. Although the distribution of chlorophytes has been widely studied, little is known about how their community composition varies along the coastal-offshore gradient in subtropical continental shelf waters. To better understand their spatial variations, we employed metabarcoding data of 18S rRNA V4 gene to examine chlorophyte composition within the surface and deep chlorophyll maximum (DCM) layers over the continental shelf in the East China Sea (ECS) with high-resolution sampling. Our results indicate a higher chlorophyte diversity in the surface layer than in the DCM. In addition, we found that chlorophytes in oligotrophic Kuroshio surface water were the most diverse, with a higher percentage of Chloropicophyceae, prasinophyte clade V, prasinophyte clade IX, Palmophyllophyceae and Chlorodendrophyceae. In more eutrophic waters along the coast and within the DCM layer, chlorophytes were dominated by Mamiellophyceae. A significant spatial variation in community composition occurred along the nutrient gradient in the subtropical continental shelf ecosystem, varying from Mamiellophyceae-dominant in coastal water to Chloropicophyceae-dominant in offshore water. Furthermore, at a low saline coastal station, which had the lowest chlorophyte diversity, Picochlorum (Trebouxiophyceae) was dominant. Overall, chlorophyte diversity was positively correlated with temperature, and negatively correlated with silicate concentration. This study revealed that terrestrial input into continental systems influences chlorophyte diversity in the subtropical northwestern Pacific Ocean.

Effects of Dietary Glycerol Monolaurate on Growth, Antioxidant Capacity and Lipid Metabolism in Cage-Farmed Pompano (Trachinotus ovatus) Juveniles - Huaxing Lin; Beiping Tan; Qihui Yang; Shuyan Chi; Hongjie Wei; Yuancai Wu; Gyan Watson Ray; Mpwaga Alatwinusa Yohana (Frontiers in Marine Science, 2022)
Glycerol monolaurate (GML), a representative fatty acid glyceride, was used to promote growth. This study investigated the effects of GML in diets on growth, serum biochemical parameters, antioxidant capacity, liver morphology and lipid metabolism for juvenile pompano Trachinotus ovatus . Six groups of T. ovatus (mean weight = 14.00 ± 0.70 g) were fed with six diets, containing varying GML levels of 0.00% (G0), 0.05% (G5), 0.10% (G10), 0.15% (G15), 0.20% (G20), and 0.25% (G25) for 8 weeks. Fish were reared for in floating cages (length: 1 m; width: 1 m; and height: 2 m). The highest weight gain rate (WGR), specific growth rate (SGR), and protein deposit rate (PDR) were observed in the G15 group ( P < 0.05). Hepatic glutathione peroxidase, total antioxidant capacity and superoxide dismutase activities were significantly increased in the G10 and G15 groups compared with the G0 group ( P < 0.05), whereas hepatic malondialdehyde (MDA) was significantly reduced in the G10 and G15 groups ( P < 0.05). The alkaline phosphatase activity was significantly higher in the G5, G10, G15, and G20 groups than in the G0 group ( P < 0.05), and the highest AKP activity was observed in the G15 group. Alanine aminotransferase (ALT) activity was significantly lower in the G10, G15, G20, and G25 groups than in the G0 group ( P < 0.05). The addition of GML to the feed significantly reduced triglyceride (TG) content ( P < 0.05). In comparison with the G0 group, the G15, G20, and G25 groups had significantly lower total cholesterol content and significantly higher high-density lipoprotein content ( P < 0.05). Low-density lipoprotein content was significantly lower in the G5 and G10 groups than in the G0 group ( P < 0.05). Serious vacuolation occurred in the G0 group, but the cell boundaries in all added groups were obvious, and the rate of intracellular vacuolization decreased. As the GML level increased, carnitine palmitoyl-transferase Ι mRNA level was significantly up-regulated ( P < 0.05). The expression of fatty acid synthesis in the G10, G15, G20, and G25 groups was significantly lower than that in the G0 group ( P < 0.05). The expression of sterol regulatory element-binding protein-Ι was significantly lower in the G10, G15, G20, and G25 groups than in the G0 group ( P < 0.05). Based on the broken-line model of WGR and PDR corresponding to GML levels, the optimum addition level of dietary GML was 0.14%-0.16% for juvenile T. ovatus . In conclusion, 0.15% GML significantly improved the growth performance, hepatic antioxidant ability, and lipid metabolism and protected the liver for juvenile pompano T. ovatus .

Preliminary establishment of a mass movement warning system for Taiwan using the soil water index - Chi-Wen Chen; Ching Hung; Guan-Wei Lin; Jun-Jih Liou; Shih-Yao Lin; Hsin-Chi Li; Yung-Ming Chen; Hongey Chen (Landslides, 2022)

SESN1, negatively regulated by miR-377-3p, suppresses invasive growth of head and neck squamous cell carcinoma by interaction with SMAD3 - Chi Zhang; Lin Ren; Hongjian Zhang; Shiwen Yang; Miao Deng; Lihong He; Ruoyan Cao; Chuanjiang Zhao; Juan Xia (Human Cell, 2022)

Fine particulate matter measured by satellites predicts the risk of age-related macular degeneration in a longitudinal cohort study - Chung-Ling Liang; Chi-Min Wang; Chau-Ren Jung; Ya-Chu Chang; Chun-Ju Lin; Yu-Ting Lin; Bing-Fang Hwang (Environmental Science and Pollution Research, 2022)

TREM-2 mediates dendritic cell–induced NO to suppress Th17 activation and ameliorate chronic kidney diseases - Ching-Cheng Lin; Ti-Yung Chang; Yong-Chen Lu; Yun-Syuan Wu; Wei Huang; Wei-Chi Lo; Guan-Fu Liu; Wei-Chan Hsu; Pamela S. Ohashi; Tak W. Mak; Jong-Ling Fuh; Hui-Chen Chen; et al. (Journal of Molecular Medicine, 2022)

Should Plate-Bone Gap be Preserved in Far-Cortical Locking Technique? A Biomechanical Study - Shun-Ping Wang; Yang-Chen Chou; Cheng-En Hsu; Chi-Wen Chou; Chao-Ping Chen; Kun-Jhih Lin; Fuu-Cheng Jiang; Wen-Chuan Chen; Chen-Chiang Lin (Journal of Medical and Biological Engineering, 2022)

Complete genome sequence of Amazon lily mosaic virus isolated from amaryllis (Hippeastrum hybridum Hort.) - Chian-Chi Lin; Shih-Shun Lin; Tsung-Chi Chen (Archives of Virology, 2022)

Exploiting Sentinel-1 data and machine learning–based random forest for collectively mapping rice fields in Taiwan - Nguyen-Thanh Son; Chi-Farn Chen; Cheng-Ru Chen; Youg-Sin Cheng; Piero Toscano; Chein-Hui Syu; Horng-Yuh Guo; Shu-Ling Chen; Tsang-Sen Liu; Yi-Ting Zhang; Huan-Sheng Lin; Shih-Hsiang Chen; et al. (Applied Geomatics, 2022)

Genotyping and phenotyping of Lactococcus garvieae isolates from fish by pulse‐field gel electrophoresis (PFGE) and electron microscopy indicate geographical and capsular variations - Shreesha Rao; Mei‐Yun Chen; Chiranan Sudpraseart; Peiry Lin; Terutoyo Yoshida; Pei‐Chi Wang; Shih‐Chu Chen (Journal of Fish Diseases, 2022)
Lactococcus garvieae is the etiological agent of Lactococcosis, an evolving disease affecting many fish species and causing significant economic losses worldwide. Assessing pathogen relatedness and bacterial population structure is critical for determining the epidemiology of L. garvieae infections and in establishing effective pathogen management methods. The previously published morphological and genetic studies point to a clonal population structure, as seen in other fish bacteria. In the present study, the pulsed‐field gel electrophoresis (PFGE) method was utilized to define a population of 41 Taiwanese isolates from outbreaks with comparisons to four well‐characterized non‐Taiwanese isolates previously published. Two restriction enzymes ( Apa I and Sma I) were utilized individually for PFGE analysis (cut‐off value = 90.0%), revealing genetic heterogeneity across L. garvieae isolates, with Apa I and Sma I yielding 12 and seven distinct PFGE band patterns, respectively. The phylogenic analysis using internal transcribed spacer region clustered all L. garvieae isolates in the same clad. Furthermore, the electron microscopic results confirmed the absence of capsular gene cluster (CGC) in previously characterized Taiwanese vaccine strain (S3) from grey mullet. Overall, our findings emphasize the importance of analysing the morphological and genetic diversity in L. garvieae being correlated for proper taxonomic classification in vaccine strain selection and epidemiological studies.

Differences in the Composition of Abundant Marine Picoeukaryotes in the Marginal Sea Derived from Flooding - Chih-Ching Chung; Gwo-Ching Gong; Yun-Chi Lin; Ching-Wei Hsu (Frontiers in Marine Science, 2022)
The transient impact of flooding on the community composition of marine picoeukaryotes (PEs, cell size ≤5 μm) in the East China Sea (ECS) was revealed in this study. In a summer without flooding (i.e., July 2009), photosynthetic picoeukaryotes (PPEs) were more abundant in the area covered by the Changjiang River diluted water (CDW, salinity ≤31) than in the non-CDW affected area. According to the 18S ribosomal RNA phylogeny, Alveolata (all from the superclass Dinoflagellata) was the main community component accounting for 72 to 99% of the community at each sampling station during the nonflooded summer. In addition to Dinoflagellata, diatoms or Chlorophyta also contributed a considerable proportion to the PE assemblage at the stations close to the edge of CDW coverage. In July 2010, an extreme flooding event occurred in the Changjiang River basin and led to the CDW covering nearly half of the ECS. In the flooded summer, the abundance of PPEs in the CDW-covered area decreased significantly to less than 1 × 10 4 cells ml -1 . Compared to that during the nonflooded summer, the diversity of the PE composition was increased. While Dinophyceae still dominated the surface waters, Syndiniophyceae, which were represented by the uncultured Marine Alveolata Group (MALV)-I and MALV-II, accounted for a substantial amount in the Dinoflagellata superclass relative to this community composition in the nonflooded summer. Furthermore, a variety of plankton, including Cryptophyta, Haptophyta, Picobiliphyta, the uncultured Marine Stramenopiles (MASTs) and heterotrophic nanoflagellates, were observed. The nutrition modes of these PEs have been reported to be mixotrophic or heterotrophic. Therefore, it was inferred that the potentially mixotrophic and heterotrophic PE compositions might be favored in the marginal sea in the flooded summer.

Development of a reverse transcription-loop mediated isothermal amplification assay for detection of wisteria vein mosaic virus - Mi-Chi Yao; Peng-Xiang Zhu; Qin-Qin Zhang; Qi-Ping Zhang; Zhao-Lin Ji; Feng Zhu (European Journal of Plant Pathology, 2022)

Effects of Recovery Ratio on the Fracture Evolution of the Overburden Pressure-Relief Gas Migration Channel for a Fully Mechanized Working Face - Pengxiang Zhao; Jianan Wang; Shugang Li; Hao Li; Lei Qin; Haifei Lin; Chi-Min Shu; Bin Laiwang; Yongyong Jia; Zongyong Wei; Wenbo Pei (Natural Resources Research, 2022)

Anti-inflammatory constituents from Phyllostachys makinoi Hayata - Chia-Ching Liaw; Yu-Chi Lin; Shao-Yu Wu; Jenny Chun-Ling Kuo; Zhi-Hu Lin; Kai-Wei Lin; Huang Hui-Chi; Li-Ming Yang Kuo; Yao-Haur Kuo (Natural Product Research, 2022)

Facing small and biased data dilemma in drug discovery with enhanced federated learning approaches - Zhaoping Xiong; Ziqiang Cheng; Xinyuan Lin; Chi Xu; Xiaohong Liu; Dingyan Wang; Xiaomin Luo; Yong Zhang; Hualiang Jiang; Nan Qiao; Mingyue Zheng (Science China Life Sciences, 2022)

Towards a rapid assessment of highway slope disasters by using multidisciplinary techniques - Meng-Chia Weng; Cheng-Han Lin; Wen-Jie Shiu; Wei-An Chao; Chia-Chi Chiu; Ching-Fang Lee; Wei-Kai Huang; Che-Ming Yang (Landslides, 2022)
Mega-earthquakes and extreme climate events accompanied by intrinsic fragile geology lead to numerous landslides along mountain highways in Taiwan, causing enormous life and economic losses. In this study, a system for rapid slope disaster information integration and assessment is proposed with the aim of providing information on landslide occurrence, failure mechanisms, and subsequent landslide-affected areas to the highway authority rapidly. The functionality of the proposed system is deployed into three units: (1) geohazard rapid report (GeoPORT I), (2) multidisciplinary geological survey report (GeoPORT II), and (3) site-specific landslide simulation report (GeoPORT III). After landslide occurrence, the seismology-based monitoring network rapidly provides the initial slope disaster information, including preliminary location, event magnitude, earthquake activity, and source dynamics, within an hour. Within 3 days of the landslide, a multidisciplinary geological survey is conducted to collect high-precision topographical, geological, and remote-sensing data to determine the possible failure mechanism. After integrating the aforementioned information, a full-scale three-dimensional landslide simulation based on the discrete element method is performed within 10 days to reveal the failure process and to identify the areas potentially affected by subsequent disasters through scenario modeling. Overall, the proposed system can promptly provide comprehensive and objective information to relevant authorities after the event occurrence for hazard assessment. The proposed system was validated using a landslide event in the Central Cross-Island Highway of Taiwan.

Evaluation of acid mine drainage sludge as soil substitute for the reclamation of mine solid wastes - Yihan Chi; Qinru Lin; Rongchuan Zhuang; Mingyu Xiong; Zhihong Ye (Environmental Science and Pollution Research, 2022)

Application of Soil and Water Assessment Tool (SWAT) to evaluate the fates of nitrogenous fertilizer in subtropical mountainous watershed tea farms - Guan-Zhou Lin; Shao-Yiu Hsu; Chia-Chun Ho; Chi-Feng Chen; Jr-Chuan Huang; Tsung-Yu Lee (Environmental Monitoring and Assessment, 2022)

Evaluating coupled hydromechanical behavior of anisotropic rock mass using DEM - Wen-Jie Shiu; Meng-Chia Weng; Chia-Chi Chiu; Po-Lin Wu (Bulletin of Engineering Geology and the Environment, 2022)

Potential anticancer activity analysis of piscidin 5-like from Larimichthys crocea - Libing Zheng; Jiayin Qiu; Huihui Liu; Changfeng Chi; Longshan Lin (Acta Oceanologica Sinica, 2022)

Prevalence, complete genome, and metabolic potentials of a phylogenetically novel cyanobacterial symbiont in the coral‐killing sponge, Terpios hoshinota - Yu‐Hsiang Chen; Hsing‐Ju Chen; Cheng‐Yu Yang; Jia‐Ho Shiu; Daphne Z. Hoh; Pei‐Wen Chiang; Wenhua Savanna Chow; Chaolun Allen Chen; Tin‐Han Shih; Szu‐Hsien Lin; Chi‐Ming Yang; James Davis Reimer; et al. (Environmental Microbiology, 2022)
Summary Terpios hoshinota is an aggressive, space‐competing sponge that kills various stony corals. Outbreaks of this species have led to intense damage to coral reefs in many locations. Here, the first large‐scale 16S rRNA gene survey across three oceans revealed that bacteria related to the taxa Prochloron , Endozoicomonas , SAR116, Ruegeria , and unclassified Proteobacteria were prevalent in T . hoshinota . A Prochloron ‐related bacterium was the most dominant and prevalent cyanobacterium in T . hoshinota . The complete genome of this uncultivated cyanobacterium and pigment analysis demonstrated that it has phycobiliproteins and lacks chlorophyll b , which is inconsistent with the definition of Prochloron . Furthermore, the cyanobacterium was phylogenetically distinct from Prochloron , strongly suggesting that it should be a sister taxon to Prochloron . Therefore, we proposed this symbiotic cyanobacterium as a novel species under the new genus Candidatus Paraprochloron terpiosi. Comparative genomic analyses revealed that ‘Paraprochloron’ and Prochloron exhibit distinct genomic features and DNA replication machinery. We also characterized the metabolic potentials of ‘Paraprochloron terpiosi’ in carbon and nitrogen cycling and propose a model for interactions between it and T. hoshinota . This study builds a foundation for the study of the T . hoshinota microbiome and paves the way for better understanding of ecosystems involving this coral‐killing sponge.

A Challenge to Conventional Fish Meal: Effects of Soy Protein Peptides on Growth, Histomorphology, Lipid Metabolism and Intestinal Health for Juvenile Pompano Trachinotus ovatus - Huaxing Lin; Beiping Tan; Gyan Watson Ray; Min Zeng; Mei Li; Shuyan Chi; Qihui Yang (Frontiers in Marine Science, 2022)
This experiment was conducted to assess the possibility of replacing fish meal (FM) with soy protein peptide (SPP) at different levels—0% (FM), 14.29% (S5), 28.57% (S10), 57.14% (S20), 71.42%(S25)—and its effects on growth, histology, gene expression related to liver lipid metabolism and intestinal immunity in juvenile pompano Trachinotus ovatus (initial mean weight = 39.88 ± 0.15 g). 600 healthy and uniformed-size fish were distributed to five groups of three replicates, each with 40 fish in each floating cage and fed twice daily for 8 weeks. Results showed that no significant difference in the growth was observed with SPP replacing FM ( P > 0.05). Serum glutathione peroxidase activity in the S10 group was significantly higher than that in the FM group, and serum malondialdehyde content significantly decreased ( P < 0.05). SPP significantly improved intestinal immunity by increasing alkaline phosphatase and lysozyme activities and up-regulating interleukin 10 and complement 4 mRNA levels while simultaneously decreasing triglyceride and total cholesterol content and down-regulating interleukin 1β mRNA expression. Villus length and muscle thickness in the S10 group were significantly higher than those in the FM group ( P < 0.05). SPP significantly improved liver fat metabolism by increasing carnitine palmitoyl transferase I mRNA levels, and down-regulating fatty acid synthesis mRNA expression ( P < 0.05). In summary, SPP substitution for FM promoted intestinal health, liver lipid metabolism and reduced liver fat accumulation for juvenile pompano T. ovatus , with no significant effect on growth performance. Based on the second-order polynomial analysis model of LYZ activity, the optimal replacement SPP level for juvenile pompano T. ovatus was 11.82%.

A First Insight Into the Heat-Induced Changes in Proteomic Profiles of the Coral Symbiotic Bacterium Endozoicomonas montiporae - Ya-Fan Chan; Chia-Yu Chen; Chih-Ying Lu; Yung-Chi Tu; Kshitij Tandon; Shinya Shikina; Sen-Lin Tang (Frontiers in Marine Science, 2022)
Endozoicomonas , a core bacterial group in corals, may also be a coral symbiont. Endozoicomonas communities often decrease rapidly in corals under heat stress. However, how the bacteria respond to changes in temperature and coral host during heat stress is unknown. Here, we employed the cultivable, dominant species E. montiporae as a working organism to explore how Endozoicomonas responds to heat stress. We designed two experiments to clarify the extent to which E. montiporae is influenced by temperature and coral host. We detected differentially expressed protein (DEP) profiles in this bacterium at 31 and 33°C compared to 25°C by tandem mass tags-based quantitative proteome analysis. Fifty DEPs, including many heat shock proteins, were detected when the temperature changed. The expression of antioxidant defense proteins and key pyruvate synthase proteins decreased, suggesting that E. montiporae were in a physiology of stress at 33°C. Furthermore, some proteins were differentially expressed because of the heat-stress-treated coral lysate specifically, suggesting that not only heat but also heat-induced host factors can affect the protein expression of the bacterium. This study provides an in-depth analysis of how the molecular mechanisms of Endozoicomonas are affected by heat stress and coral host.

Comprehensive review on catalytic degradation of Cl-VOCs under the practical application conditions - Fawei Lin; Li Xiang; Zhiman Zhang; Na Li; BeiBei Yan; Chi He; Zhengping Hao; Guanyi Chen (Critical Reviews in Environmental Science and Technology, 2022)

Downregulated Calcium-Binding Protein S100A16 and HSP27 in Placenta-Derived Multipotent Cells Induce Functional Astrocyte Differentiation - Yu-Che Cheng; Chi-Jung Huang; Wei-Chi Ku; Shu-Lin Guo; Lu-Tai Tien; Yih-Jing Lee; Chih-Cheng Chien (Stem Cell Reviews and Reports, 2022)
Little is known about genes that induce stem cells differentiation into astrocytes. We previously described that heat shock protein 27 (HSP27) downregulation is directly related to neural differentiation under chemical induction in placenta-derived multipotent stem cells (PDMCs). Using this neural differentiation cell model, we cross-compared transcriptomic and proteomic data and selected 26 candidate genes with the same expression trends in both omics analyses. Those genes were further compared with a transcriptomic database derived from Alzheimer’s disease (AD). Eighteen out of 26 candidates showed opposite expression trends between our data and the AD database. The mRNA and protein expression levels of those candidates showed downregulation of HSP27, S100 calcium-binding protein A16 (S100A16) and two other genes in our neural differentiation cell model. Silencing these four genes with various combinations showed that co-silencing HSP27 and S100A16 has stronger effects than other combinations for astrocyte differentiation. The induced astrocyte showed typical astrocytic star-shape and developed with ramified, stringy and filamentous processes as well as differentiated endfoot structures. Also, some of them connected with each other and formed continuous network. Immunofluorescence quantification of various neural markers indicated that HSP27 and S100A16 downregulation mainly drive PDMCs differentiation into astrocytes. Immunofluorescence and confocal microscopic images showed the classical star-like shape morphology and co-expression of crucial astrocyte markers in induced astrocytes, while electrophysiology and Ca 2+ influx examination further confirmed their functional characteristics. In conclusion, co-silencing of S100A16 and HSP27 without chemical induction leads to PDMCs differentiation into functional astrocytes. Graphical abstract

Structure related α-glucosidase inhibitory activity and molecular docking analyses of phenolic compounds from Paeonia suffruticosa - Po-Chun Chen; Bongani Sicelo Dlamini; Chiy-Rong Chen; Yueh-Hsiung Kuo; Wen-Ling Shih; Yun-Sheng Lin; Chien-Hsing Lee; Chi-I Chang (Medicinal Chemistry Research, 2022)

Feasibility and usability of a mobile health tool on anticoagulation management for patients with atrial fibrillation: a pilot study - Chi Zhang; Mang-Mang Pan; Na Wang; Wei-Wei Wang; Zheng Li; Zhi-Chun Gu; Hou-Wen Lin (European Journal of Clinical Pharmacology, 2022)

Otolith Microstructure Analysis Reveals Different Growth Histories of Japanese Sardine (Sardinops melanostictus) in the Oyashio Waters - Chunlin Liu; Chi Zhang; Yongjun Tian; Liangming Wang; Longshan Lin; Yuan Li; Yoshiro Watanabe (Journal of Ocean University of China, 2022)

Research on hoop capacity of composite foundation of discarded rubber tires - Feng-Chi Wang; Jun Li; Zhen-Huan Lin; Pei-Pei Tian; Han-Yu Zhao (European Journal of Environmental and Civil Engineering, 2022)

miRNA–mRNA Integrative Analysis Reveals the Roles of miRNAs in Hypoxia-Altered Embryonic Development- and Sex Determination-Related Genes of Medaka Fish - Keng Po Lai; Nathan Yi Kan Tam; Yuelong Chen; Chi Tim Leung; Xiao Lin; Chau Fong Tsang; Yin Cheung Kwok; William Ka Fai Tse; Shuk Han Cheng; Ting Fung Chan; Richard Yuen Chong Kong (Frontiers in Marine Science, 2022)
Recent studies have shown hypoxia to be an endocrine disruptor that impairs sex differentiation and reproductive function, leading to male-biased F1 populations in fish. However, the molecular mechanisms through which hypoxia alters fish sex differentiation and therefore sex ratios remain poorly understood. In order to understand the potential role of miRNAs in mediating hypoxia-altered sex determination and differentiation in fish, we conducted small RNA sequencing and transcriptome sequencing on marine medaka ( Oryzias melastigma ) embryos that were exposed to hypoxia (2.0 ± 0.2 mg O 2 L – 1) for 40 h (encompassing a critical window of sex determination). We identified dysregulated miRNAs and mRNAs in the hypoxia-exposed embryo, and bioinformatic analysis of the integrative small RNA sequencing and transcriptome sequencing results revealed hypoxia to cause alterations of genes related to embryonic development through miRNA regulation. Importantly, we have identified miRNA-mRNA pairs that were reported to play roles in gonad development (novel miR-145-col9a3 and novel miRNA-94- arid5b), in sex hormone response (novel miRNA-210-ca2, novel miRNA-106-nr2f2, nbr-miR-29c-nr4a1, and ola-miR-92b-akr1d1), and in sex characteristic development (novel miRNA-145-mns1, nle-miR-20-sord, and ipu-miR-219b-abcc8). Our findings highlighted the possible roles of miRNA–mRNA in regulation of embryonic development and sex determination in response to hypoxic stress.

Coupling Relationship of Human Activity and Geographical Environment in Stage-Specific Development of Urban Coastal Zone: A Case Study of Quanzhou Bay, China (1954–2020) - Xianbiao Xiao; Yunhai Li; Fangfang Shu; Liang Wang; Jia He; Xiaochun Zou; Wenqi Chi; Yuting Lin; Binxin Zheng (Frontiers in Marine Science, 2022)
Owing to the development of the social economy, the geographical environment and ocean utilization patterns of urban coastal zones have changed. This change, in turn, has influenced the socio-economic development of urban coastal zones. Based on the Geographic Information System technology, the area, coastline length, and shoreland use function of reclamation areas were obtained from the geographic charts (1954–2020) and remote sensing data (1988–2017) of Quanzhou Bay. In this study, we analyzed the geomorphologic change process and the relationship between land use patterns and economic development in Quanzhou Bay from the perspectives of hydrodynamics, sediments, and human activity. Our results indicated that over the past 70 years, the bay area has reduced by 21.5%. The length of the coastline decreased from 208.36 km in 1959 to 149.11 km in 1988, whereas the shape index of the bay (SIB) decreased from 3.09 to 2.41 during the same period. Between 1988 and 2017, the coastline increased to 162.91 km, causing the SIB to increase to 2.72. The artificial index of the bay increased from 0.28 in 1959 to 0.90 in 2017. The intensity of bay the development (IBD) first increased from 0.27 in 1959 to 0.77 in 2006. During the transition to a more modern society (2006 to present), the IBD slightly decreased to 0.73 in 2017. Affected by human activity, the transformation of the reclaimed land in Quanzhou Bay can be divided into four stages that are closely linked to the economic development in the region. In the early industrialization period, reclaimed land in the region was used for agricultural production, whereas in the mid-industrialization period, it was gradually transformed into a combination of industrial (29.8%) and agricultural (56.1%) lands. In the later period of industrialization, the reclaimed land was gradually converted into urban industrial and port lands. Finally, with further refinement and upgrading of economic and industrial structures, the socio-economic and environmental benefits from coastal reclamation projects have been increasing, whereas the proportion of economic benefits (in the total benefits) has been decreasing. The results of this study can provide decision-making references for the optimization of utilization patterns and the economic development of reclamation lands in coastal areas.

Identification and Expression Characterization of the Smad3 Gene and SNPs Associated with Growth Traits in the Hard Clam (Meretrix meretrix) - Lulu Fu; Qiudie Chi; Yongbo Bao; Hanhan Yao; Zhihua Lin; Yinghui Dong (Fishes, 2021)
It has been demonstrated that the sekelsky mothers against decapentaplegic homolog 3 (Smad3) plays an important role in the growth and development of vertebrates. However, little is known about the association between the Smad3 gene and the growth traits of mollusks. In this study, Smad3 from the hard clam Meretrix meretrix (Mm-Smad3) was cloned, characterized, and screened for growth-related single nucleotide polymorphisms (SNPs) in its exons. The full-length cDNA of Mm-Smad3 was 1938 bp, encoding a protein with 428 amino acid residues. The protein sequence included an MH1 (27–135 aa) and MH2 domain (233–404 aa). Promoter analysis showed that the promoter sequence of Mm-Smad3 was 2548 bp, and the binding sites of Pit-1a, Antp, Hb, and other transcription factors are related to the growth and development of hard clams. The phylogenetic tree was divided into two major clusters, including mollusks and vertebrate. The expression level of Mm-Smad3 was predominantly detected in the mantle and foot, while extremely less expression was observed in the digestive gland. The low expression level of Mm-Smad3 was detected at the stages of unfertilized mature eggs, fertilized eggs, four-cell embryos, blastula, gastrulae, trochophore, and D-shaped larvae, whereas an opposite trend was observed regarding the highest expression at the umbo larvae stage (p T, c.660 C > T, c.792 A > T) were significantly related to the growth traits of clam (p

Strategies for the Low Sulfur Policy of IMO—An Example of a Container Vessel Sailing through a European Route - Pei-Chi Wu; Cherng-Yuan Lin (Journal of Marine Science and Engineering, 2021)
Ships are an important part in international trade transportation and a major source of pollution. Therefore, the International Maritime Organization (IMO) implemented an amendment to the International Convention for the Prevention of Pollution from Ships (MARPOL) Annex VI, which stipulates that the sulfur content in marine fuel oil shall not exceed 0.5 wt.% starting in 2020. In order to meet the IMO low sulfur policy, shipping lines could adopt one of the following strategies: (1) using very low sulfur fuel oil (VLSFO), i.e., with sulfur content less than 0.5 wt.%; (2) installing scrubbers or other exhaust gas aftertreatment systems; or (3) replacing current fuels with clean alternative fuels such as natural gas. This study evaluates the feasibility and benefits of these strategies for shipping lines in order to determine the most cost-effective measures. First, according to the feasibility of the strategies evaluated by SWOT analysis, although scrubbers can reduce emissions of sulfur oxides into the atmosphere, more and more countries are restricting the discharge of wastewater from open-loop scrubbers into their waters. Instead, VLSFO and liquefied natural gas (LNG) are good choices in terms of environmental protection and economic benefits. Therefore, this study further evaluates the two strategies of replacing high sulfur fuel oil (HSFO) with VLSFO and converting diesel engines to LNG engines based on a cost-benefit methodology. This study took an 8500 TEU container vessel, which is powered by a marine diesel engine with the nominal power of 61,800 kW, sailing the Asian-European route as an example, and calculated the total incremental costs, pollutant emission reductions, and cost benefits arising from the implementation of the VLSFO and LNG strategies, respectively. According to the results of this study, the total incremental cost of LNG is higher than that of VLSFO in the first 4.7 years, but this gradually decreases, making the gap of the total incremental costs between the two strategies wider year by year. In comparison with using HSFO without any improvement, the total incremental costs of the VLSFO and LNG strategies increase by 12.94% and 22.16% over the following five years, respectively. The use of LNG can significantly reduce SOx, PM, NOx, and CO2 emissions; on the other hand, it leads to more CH4 emissions than the VLSFO strategy. Compared to doing nothing, the cumulative reduction rates of SOx, PM, NOx, and CO2 emissions over the next five years after the adoption of the LNG strategy are 3.6%, 7.0%, 70.4%, and 15.7%, respectively. The higher emission reduction rates of LNG compared to VLSFO illustrate that the former has a good effect on the suppression of exhaust gas pollution. In terms of the cost-benefit evaluation of the two strategies, this study shows that the VLSFO strategy is more cost-effective than the LNG strategy in the first 2.5 years, but that the cost-benefit ratio of the latter increases year by year and exceeds that of the former, and the gap between them widens year by year. Based on the evaluation results of this study, the LNG strategy is suitable for ocean-going container vessels with fixed routes and younger or larger sized vessels to meet the IMO low sulfur policy. In contrast, the VLSFO strategy is appropriate for old merchant ships with fewer container spaces. LNG is a suitable medium- and long-term strategy, i.e., for more than 2.5 years, for shipping lines to meet the IMO low sulfur policy, while VLSFO is a suitable short-term strategy.

Intramyocardial injection of human adipose-derived stem cells ameliorates cognitive deficit by regulating oxidative stress–mediated hippocampal damage after myocardial infarction - Tsung-Ming LEE; Cheng-Che LEE; Horng-Jyh HARN; Tzyy-Wen Chiou; Ming-Hsi CHUANG; Chun-Hung CHEN; Chi-Hsuan CHUANG; Po-Cheng LIN; Shinn-Zong LIN (Journal of Molecular Medicine, 2021)
Cognitive impairment is a serious side effect of post-myocardial infarction (MI) course. We have recently demonstrated that human adipose-derived stem cells (hADSCs) ameliorated myocardial injury after MI by attenuating reactive oxygen species (ROS) levels. Here, we studied whether the beneficial effects of intramyocardial hADSC transplantation can extend to the brain and how they may attenuate cognitive dysfunction via modulating ROS after MI. After coronary ligation, male Wistar rats were randomized via an intramyocardial route to receive either vehicle, hADSC transplantation (1 × 10 6 cells), or the combination of hADSCs and 3-Morpholinosydnonimine (SIN-1, a peroxynitrite donor). Whether hADSCs migrated into the hippocampus was assessed by using human-specific primers in qPCR reactions. Passive avoidance test was used to assess cognitive performance. Postinfarction was associated with increased oxidative stress in the myocardium, circulation, and hippocampus. This was coupled with decreased numbers of dendritic spines as well as a significant downregulation of synaptic plasticity consisting of synaptophysin and PSD95. Step-through latency during passive avoidance test was impaired in vehicle-treated rats after MI. Intramyocardial hADSC injection exerted therapeutic benefits in improving cardiac function and cognitive impairment. None of hADSCs was detected in rat’s hippocampus at the 3rd day after intramyocardial injection. The beneficial effects of hADSCs on MI-induced histological and cognitive changes were abolished after adding SIN-1. MI-induced ROS attacked the hippocampus to induce neurodegeneration, resulting in cognitive deficit. The remotely intramyocardial administration of hADSCs has the capacity of improved synaptic neuroplasticity in the hippocampus mediated by ROS, not the cell engraftment, after MI. Key messages Human adipose-derived stem cells (hADSCs) ameliorated injury after myocardial infarction by attenuating reactive oxygen species (ROS) levels. Intramyocardial administration of hADSCs remotely exerted therapeutic benefits in improving cognitive impairment after myocardial infarction. The improved synaptic neuroplasticity in the hippocampus was mediated by hADSC-inhibiting ROS, not by the stem cell engraftment.

Realization of Natural Human Motion on a 3D Biped Robot For Studying the Exoskeleton Effective - Chi-Ying Lee; Shih Chieh Lan; Jung-Ji Lin; Yu-Ting Lin; Po-Shen Chiang; Wei-Li Hsu; Kuo-Kuang Jen; Andy Y. S. Huang; Jia-Yush Yen (Journal of Medical and Biological Engineering, 2021)

The Rapidly Evolving Fudu Estuary Sandbar Lagoon Landform on the East Coast of the Bohai Sea: Recent Changes and Mechanism - Lianjie Zhang; Jishun Yan; Bo Zhao; Xia Lin; Peng Wang; Chi Zhang; Yonghai Yu; Pan Zhang (Journal of Marine Science and Engineering, 2021)
The Fudu Estuary Sandbar Lagoon is one of the most representative sandbar-lagoon landforms in China, and has undergone drastic evolution in recent years, accompanied by increased coastal engineering activities. The evolution process and its control factors are studied through remote sensing interpretation and coastal sediment transport calculations. During 2010–2021, the sandbar quickly extended at an average speed of 49.5 m/a, but the annual growth has shown a decreasing trend in both area and width, and the shoreline has retreated by 25–45 m. The recent changes are the result of the combined action of natural conditions and human activities. Coastal sediment transport from west to east under the action of W-oriented waves is the natural cause of extension. An estuary dam and artificial island block the sediment transport path, and the material for the new growth of the sandbar comes from the erosion of its west side, which has directly caused the retreat and narrowing of the sandbar. The reduction in sediments from the river further aggravates the shrinkage. It is predicted that the sandbar will continue its eastward extension to connect with the coast in about 2–3 years. The erosion status is unlikely to change before the sediment supply is restored. Measures such as dismantling the estuary dam are recommended.

A New Instrumental Array in Sichuan, China, to Monitor Vibrations and Perturbations of the Lithosphere, Atmosphere, and Ionosphere - Chieh-Hung Chen; Yang-Yi Sun; Kai Lin; Chen Zhou; Rui Xu; Haiyin Qing; Yongxin Gao; Tao Chen; Fei Wang; Huaizhong Yu; Peng Han; Chi-Chia Tang; et al. (Surveys in Geophysics, 2021)

Three new species of Cylindrobasidium (Physalacriaceae, Agaricales) from East Asia - Yi-Chung Lin; Chia-Ling Wei; Chi-Yu Chen; Che-Chih Chen; Sheng-Hua Wu (Mycological Progress, 2021)

Effect of dietary supplementation with Chlorella sorokiniana meal on the growth performance, antioxidant status, and immune response of rainbow trout (Oncorhynchus mykiss) - Weijun Chen; Lin Luo; Danxiang Han; Feiping Long; Qinglei Chi; Qiang Hu (Journal of Applied Phycology, 2021)

Comparing the clinical outcomes across different sodium/glucose cotransporter 2 (SGLT2) inhibitors in heart failure patients: a systematic review and network meta-analysis of randomized controlled trials - Yao Hao Teo; Celine Shuen Yin Yoong; Nicholas L. Syn; Yao Neng Teo; Jia Yang Alex Cheong; Yoke-Ching Lim; Chi-Hang Lee; Tiong-Cheng Yeo; Ping Chai; Raymond C. C. Wong; Weiqin Lin; Ching-Hui Sia (European Journal of Clinical Pharmacology, 2021)

Resveratrol Mitigates Cerebral Ischemic Injury by Altering Levels of Trace Elements, Toxic Metal, Lipid Peroxidation, and Antioxidant Activity - Ju-Hai Ro; Chien-Chi Liu; Ming-Cheng Lin (Biological Trace Element Research, 2021)

Exercise renovates H2S and Nrf2-related antioxidant pathways to suppress apoptosis in the natural ageing process of male rat cortex - Jing-Ying Lin; Tsung-Jung Ho; Bruce Chi-Kang Tsai; Chien-Yi Chiang; Hui-Chuan Kao; Wei-Wen Kuo; Ray-Jade Chen; Vijaya Padma Viswanadha; Chi-Wen Huang; Chih-Yang Huang (Biogerontology, 2021)

Anti-Inflammatory and anti-proliferative oleanane-type triterpene glycosides from the vine of Momordica cochinchinensis - Hung-Tse Huang; Yu-Chi Lin; Li-Jie Zhang; Chia-Ching Liaw; Hsin-Yen Chen; Ming-Tung Hsueh; Yao-Haur Kuo (Natural Product Research, 2021)

Association Between Estuary Characteristics and Activities of the Critically Endangered Indo-Pacific Humpback Dolphin (Sousa chinensis) - Chi-hung Lin; Hsing-Juh Lin; Jian-Ping Suen; Lien-Siang Chou (Frontiers in Marine Science, 2021)
The Indo-Pacific humpback dolphin ( Sousa chinensis ) has been reported to prefer estuary habitats. This study explored the environmental factors affecting a critically endangered population off the coast of Yunlin, Taiwan. We measured dolphin sighting rates and estuary characteristics affected by the watershed, including seven physical factors (watershed rainfall, watershed runoff, estuarine turbidity, pH, salinity, temperature, and dissolved oxygen) and two biological factors (estuarine net primary production and chlorophyll a concentration), at the Hsinhuwei River estuary in Taiwan. Dolphin activity was measured by sighting rate and behavioral indices for feeding and traveling between 2017 and 2018. We observed that when the maximum net production increased alongside rising temperatures in spring, both the dolphin sighting rate and foraging activity increased. This trend was maintained until heavy rainfall or increased river runoff occurred during late summer, which resulted in high turbidity in autumn and winter. Turbidity was significantly negatively correlated with dolphin activity (sighting rate and foraging). Furthermore, we found that dolphin traveling positively correlated with the chlorophyll a concentration and maximum net production factors, which could attract dolphins expecting more abundant prey fish in the estuary supported by the high primary production. This study provides empirical evidence on how estuary characteristics affected by the watershed can affect the sighting rate and behavioral activities of Indo-Pacific humpback dolphins.

Wogonin Accelerates Hematoma Clearance and Improves Neurological Outcome via the PPAR-γ Pathway After Intracerebral Hemorrhage - Jianfeng Zhuang; Yucong Peng; Chi Gu; Huihui Chen; Zheng Lin; Hang Zhou; Xiao Wu; Jianru Li; Xiaobo Yu; Yang Cao; Hanhai Zeng; Xiongjie Fu; et al. (Translational Stroke Research, 2021)

Spontaneous thought-related network connectivity predicts sertraline effect on major depressive disorder - Li-Ming Hsu; Timothy Joseph Lane; Changwei W. Wu; Chien-Yuan Lin; Chi-Bin Yeh; Hung-Wen Kao; Ching-Po Lin (Brain Imaging and Behavior, 2021)

Efficacy of Entomopathogenic fungus Aspergillus nomius against Dolichoderus thoracicus - Wei-Jiun Lin; Ming-Chung Chiu; Chung-Chi Lin; Yuan-Kai Chung; Jui-Yu Chou (BioControl, 2021)

Pomelo fruit wastes are potentially valuable antioxidants, anti-inflammatories, antihypertensives, and antihyperglycemics - Li-Yun Lin; Chi-Yun Huang; Kuan-Chou Chen; Robert Y. Peng (Horticulture, Environment, and Biotechnology, 2021)
Grapefruit (G) parts contain abundant phenolic acids and flavonoids (PPNs and FLVs). The wastes created from exocarps, mesocarps (G wastes, GW) and waste blanching water (WBW) lead to a considerable loss of PPNs and FLVs. Here, we assessed Buntan (CB), Buntan Hayata (CBH), and Peiyu (CP) cultivars and observed considerable amounts of PPNs and FLVs. The ethanolic extracts of GW (GWE) and WBW contained gallic acid, protocatechuic acid, chlorogenic acid, caffeic acid, ferulic acid, coumaric acid, naringin, hesperidin, diosmin, quercetin, hesperetin, nobiletin, and tangeretin (GWC). GWE has previously been reported to be a relatively active antioxidant, anti-inflammatory (based on the expression of TNF-α in Raw264.7 cells), antihypertensive, and anti-hyperglycemic compound. The IC 50 values for antihyperglycemic activity with WBW for α-amylase were as follows: CB (27.96 ± 0.03 mg/mL) < CP (28.13 ± 0.19 mg/mL) < CBH (41.60 ± 0.16 mg/mL), and those for α-glucosidase were CB (1.80 ± 0.03 mg/mL) < CP (2.97 ± 0.29 mg/mL) < CBH (9.10 ± 0.51 mg/mL). GWC upregulated Glut4 in HepG2 cells, as well as the insulin secretion capability, and intracellular levels in RIN-m5F cells, and it downregulated DPP4 in HepG2 cells. The IC 50 values for the angiotensin-converting enzyme activity were: CBP (5.10 ± 0.02 mg/mL) < CB (7.24 ± 0.65 mg/mL) < CP (8.60 ± 2.03 mg/mL). Our results indicate that PPNs and FLVs present in GW are worth reclaiming.

Environmental microorganism classification using optimized deep learning model - Chih-Ming Liang; Chun-Chi Lai; Szu-Hong Wang; Yu-Hao Lin (Environmental Science and Pollution Research, 2021)

Effect of dermal phthalate levels on lung function tests in residential area near a petrochemical complex - Chih-Wen Wang; Szu-Chia Chen; Da-Wei Wu; Huang-Chi Chen; Hung-Hsun Lin; Hung Su; Jen-taie Shiea; Wen-Yi Lin; Chih-Hsing Hung; Chao-Hung Kuo (Environmental Science and Pollution Research, 2021)

A dye combination for the staining of pollen coat and pollen wall - Xin-Lei Jia; Jing-Shi Xue; Fang Zhang; Chi Yao; Shi-Yi Shen; Chang-Xu Sui; Yu-Jia Peng; Qin-Lin Xu; Yi-Feng Feng; Wen-Jing Hu; Ping Xu; Zhong-Nan Yang (Plant Reproduction, 2021)

Computed Tomography Super-Resolution Using a Generative Adversarial Network in Bronchoscopy: A Clinical Feasibility Study - Heng-sheng Chao; Tsu-Hui Shiao; Chung-Wei Chou; Fang-Chi Lin; Yu-Te Wu; Der-Ming Liou (Journal of Medical and Biological Engineering, 2021)

MiR-124 and Small Molecules Synergistically Regulate the Generation of Neuronal Cells from Rat Cortical Reactive Astrocytes - Yangyang Zheng; Zhehao Huang; Jinying Xu; Kun Hou; Yifei Yu; Shuang Lv; Lin Chen; Yulin Li; Chengshi Quan; Guangfan Chi (Molecular Neurobiology, 2021)

Influence of different fluidization and gasification parameters on syngas composition and heavy metal retention in a two-stage fluidized bed gasification process - Jia-Hong Kuo; Chiou-Liang Lin; Chang-Yu Ho; Jia-Chi Hung (Environmental Science and Pollution Research, 2021)

Effects of Climate Change in Marine Ecosystems Based on the Spatiotemporal Age Structure of Top Predators: A Case Study of Bigeye Tuna in the Pacific Ocean - Kuo-Wei Lan; Yan-Lun Wu; Lu-Chi Chen; Muhamad Naimullah; Tzu-Hsiang Lin (Frontiers in Marine Science, 2021)
How top predators behave and are distributed depend on the conditions in their marine ecosystem through bottom−up forcing; this is because where and when these predators can feed and spawn are limited and change often. This study investigated how the catch rates of immature and mature cohorts of bigeye tuna (BET) varied across space and time; this was achieved by analyzing data on the Taiwanese longline fishery in the western and central Pacific Ocean (WCPO). We also conducted a case study on the time series patterns of BET cohorts to explore the processes that underlie the bottom-up control of the pelagic ecosystem that are influenced by decadal climate events. Wavelet analysis results revealed crucial synchronous shifts in the connection between the pelagic ecosystems at low trophic levels in relation to the immature BET cohort. Many variables exhibited decreasing trends after 2004–2005, and we followed the Pacific Decadal Oscillation (PDO) as a bottom-up control regulator. The results indicated that low recruitment into the mature cohort occurs 3 years after a decrease in the immature cohort’s food stocks, as indicated by a 3-year lag in our results. This finding demonstrated that, by exploring the connection between low-trophic-level species and top predators at various life stages, we can better understand how climate change affects the distribution and abundance of predator fish.

New secondary metabolite with cytotoxicity from spawning soft coral Asterospicularia laurae in Taiwan - Jui-Hsin Su; Chih-I Liu; Mei-Chin Lu; Chi-I Chang; Min-Ying Hsieh; Yu-Chi Lin; Chang-Feng Dai; Ya-Han Zhang; Zheng-Yu Lin; Yun-Sheng Lin (Natural Product Research, 2021)

Microbiome Reengineering by Heat Selection for Rapid Biodegradation of Trichloroethylene with Minimal Vinyl Chloride Formation - Ai-Lin Chan; Chien-Yun Tseng; Tzu-Wen Chen; Yi-Hsuan Lo; Shu-Chi Chang (Water, Air, & Soil Pollution, 2021)

Interest-activity symptom severity predicts response to ketamine infusion in treatment-resistant depression - Mu-Hong Chen; Wei-Chen Lin; Hui-Ju Wu; Ya-Mei Bai; Cheng-Ta Li; Shih-Jen Tsai; Chen-Jee Hong; Pei-Chi Tu; Tung-Ping Su (Psychopharmacology, 2021)

Syndecan-3 contributes to the regulation of the microenvironment at the node of Ranvier following end-to‑side neurorrhaphy: sodium image analysis - Chiung-Hui Liu; Yu-Chen Kuo; Che-Yu Wang; Chao-Chun Hsu; Ying-Jui Ho; Yun-Chi Chiang; Fu-Der Mai; Wei-Jhih Lin; Wen-Chieh Liao (Histochemistry and Cell Biology, 2021)

The Biomechanical Response of the Lower Cervical Spine Post Laminectomy: Geometrically-Parametric Patient-Specific Finite Element Analyses - Mohammad Nikkhoo; Chih-Hsiu Cheng; Jaw-Lin Wang; Chi-Chien Niu; Mohamad Parnianpour; Kinda Khalaf (Journal of Medical and Biological Engineering, 2021)

Reliability and Validity of a Mobile Device for Assessing Head Control Ability - Mohammad Nikkhoo; Chi-Chien Niu; Chen-Ju Fu; Meng-Ling Lu; Wen-Chien Chen; Yang-Hua Lin; Chih-Hsiu Cheng (Journal of Medical and Biological Engineering, 2021)

Direct Calculation Method for the Analysis of Non-linear Behavior of Ground-Support Interaction of a Circular Tunnel Using Convergence Confinement Approach - Yu-Lin Lee; Wen-Kuei Hsu; Chi-Min Lee; Yi-Xian Xin; Bo-Yu Zhou (Geotechnical and Geological Engineering, 2021)

Patterns of chronic disease management and health outcomes in a population-based cohort of Black women with breast cancer - Michelle Doose; Jennifer Tsui; Michael B. Steinberg; Cathleen Y. Xing; Yong Lin; Joel C. Cantor; Chi-Chen Hong; Kitaw Demissie; Elisa V. Bandera (Cancer Causes & Control, 2021)

Analysis of Meteorological Drought Resilience and Risk Assessment of Groundwater Using Signal Analysis Method - Yuan-Chien Lin; En-Dian Kuo; Wan-Ju Chi (Water Resources Management, 2021)

Risk of mental illness after the diagnosis of occupational injury or disease: a retrospective cohort study - Ming-Hung Lin; Ya-Lun Yang; Fung-Chung Sung; Chiu-Shong Liu; Chi-Hsuan Lung; Jong-Yi Wang (International Archives of Occupational and Environmental Health, 2021)

Cost-Benefit Evaluation on Promising Strategies in Compliance with Low Sulfur Policy of IMO - Pei-Chi Wu; Cherng-Yuan Lin (Journal of Marine Science and Engineering, 2020)
According to the amendment of the “International Convention for the Marine Prevention of Pollution from Ships” (MARPOL), Annex VI stating that the sulfur content in marine fuel oil cannot exceed 0.5 wt. % came into effect in 2020. This study uses cost-benefit analysis method to evaluate the feasibility and implementation benefits of those strategies. A container ship serving on the ship route is selected as a representative. It is found that the very low-sulfur fuel oil (VLSFO) strategy has a higher total incremental cost than the scrubber strategy in the first 4.14 years, but then, the trend is reversed. After this container ship is equipped with a scrubber, the pollutant emission reduction is 5% higher than the condition of VLSFO only in the first year. The SOx and PM emission reduction rates of VLSFO strategy are higher than that of the scrubber strategy by 9% and 25%, respectively, within five years. In addition, during 3.3 years after the scrubber is installed, the cost-benefit ratio is higher than that of the VLSFO strategy. Hence, the scrubber for the ocean route container ships is merely a short-term compliance strategy within 3.3 years. In contrast, the low sulfur fuel oil strategy that less pollutant is emitted is a compliance strategy for periods longer than 3.3 years.

Urbanization and carbon emission: causality evidence from the new industrialized economies - Khalid Khan; Chi-Wei Su; Ran Tao; Lin-Na Hao (Environment, Development and Sustainability, 2020)

Optimizing the MIC breakpoints of amoxicillin and tetracycline for antibiotic selection in the rescue therapy of H. pylori with bismuth quadruple regimen - Ming-Tsung Hsieh; Wei-Lun Chang; Chung-Tai Wu; Hsiao-Bai Yang; Hsin-Yu Kuo; Meng-Ying Lin; Hsiu-Chi Cheng; Yu-Chin Tsai; Bor-Shyang Sheu (European Journal of Clinical Pharmacology, 2020)

Correction to: Complete genome sequences of two novel dicistroviruses detected in yellow crazy ants (Anoplolepis gracilipes) - Chih-Chi Lee; Chun-Yi Lin; Hung-Wei Hsu; Chin-Cheng Scotty Yang (Archives of Virology, 2020)

Complete genome sequences of two novel dicistroviruses detected in yellow crazy ants (Anoplolepis gracilipes) - Chih-Chi Lee; Chun-Yi Lin; Hung-Wei Hsu; Chin-Cheng Scotty Yang (Archives of Virology, 2020)

The Bearing Capacity Evaluations of a Spread Footing on Single Thick Stratum or Two-Layered Cohesive Soils - Chao-Ming Chi; Zheng-Shan Lin (Journal of Marine Science and Engineering, 2020)
Nowadays many countries plan to increase the percentages of renewable energies by developing offshore wind power. Due to the large sizes of offshore foundations, such as spudcan footings of jack-up barges or pile anchors of wind turbines, the affected soil depth range caused by the foundation under loading can be relatively deep, so the affected range may include a single thick layer or stratified soils. This paper utilizes limit analysis and FLAC numerical simulation to investigate the bearing capacity of a footing on single thick stratum or two-layered cohesive soils. Under nature deposition condition, the undrained shear strength of most cohesive soil approximately increases linearly as the depth increases. The closed-form upper bound solutions of fully rough or fully smooth footings on thick cohesive soils are provided, for the purpose of fast evaluations in practical engineering, and the outcomes are within the results from the FLAC simulation and slip circle method. The problems of punch-through shear failure or soil squeezing could be critical for two-layered soils under some conditions, and the associated bearing factors and the failure mechanisms from different methods are demonstrated and discussed in the article.

Machine learning approaches for rice crop yield predictions using time-series satellite data in Taiwan - Nguyen-Thanh Son; Chi-Farn Chen; Cheng-Ru Chen; Horng-Yuh Guo; Youg-Sing Cheng; Shu-Ling Chen; Huan-Sheng Lin; Shih-Hsiang Chen (International Journal of Remote Sensing, 2020)

A new macrocyclic diterpenoid from Anisomeles indica - Chen-Liang Chao; Hui-Chi Huang; Hsiou-Yu Ding; Jenn-Haung Lai; Hang-Ching Lin; Wen-Liang Chang (Natural Product Research, 2020)

Mild acidity likely accelerates the physiological matriptase autoactivation process: a comparative study between spontaneous and acid-induced matriptase zymogen activation - Bailing Jia; Hamishi A. Thompson; Robert B. Barndt; Yi-Lin Chiu; Mon-Juan Lee; See-Chi Lee; Jehng-Kang Wang; Hung-Jen Tang; Chen-Yong Lin; Michael D. Johnson (Human Cell, 2020)

Feasibility of using bed filters packed with rice-straw-based activated carbon and selected biomass waste for the control of frying fume exhaust - Yen-Chi Chen; Xuan-En Yang; Kun-Yi Lin; Wei-Wen Huang; Chi-Chi Lin; Kuo-Pin Yu (Environmental Science and Pollution Research, 2020)

An ensemble learning based hybrid model and framework for air pollution forecasting - Yue-Shan Chang; Satheesh Abimannan; Hsin-Ta Chiao; Chi-Yeh Lin; Yo-Ping Huang (Environmental Science and Pollution Research, 2020)

Assessment of heavy metal contamination and adverse biological effects of an industrially affected river - Gavin Yeh; Hong-Giang Hoang; Chitsan Lin; Xuan-Thanh Bui; Huu-Tuan Tran; Chien-Chuan Shern; Chi-Thanh Vu (Environmental Science and Pollution Research, 2020)

Small RNA profiling reveal regulation of microRNAs in field peanut pod rot pathogen infection - Mian Wang; Chao-xin Zhang; Li-juan Pan; Tong Wang; Na Chen; Ming-na Chen; Zhen Yang; Xin-gang Guo; Shan-lin Yu; Xiao-yuan Chi (Biologia, 2020)

Using High-resolution Remote Sensing Images to Detect Freshwater Ecosystem Changes – a New Perspective of Different Ecosystem Types and Shapes - Chen Lin; Hao Cheng; Chi Zhang; Yang Zhang; Liangjie Wang (Water Resources Management, 2020)

Evaluating the severity of building fires with the analytical hierarchy process, big data analysis, and remote sensing - Ching-An Lee; Yu-Chi Sung; Yuan-Shang Lin; Gary Li-Kai Hsiao (Natural Hazards, 2020)

TNFSF13 upregulation confers chemotherapeutic resistance via triggering autophagy initiation in triple-negative breast cancer - Hui-Yu Lin; Chia-Hao Kuei; Hsun-Hua Lee; Che-Hsuan Lin; Yen-Lin Chen; Chi-Long Chen; Yuan-Feng Lin (Journal of Molecular Medicine, 2020)

On the mechanism of soft clay being improved entirely in the ECT treatment - Chang-Yu Ou; Chien-Yu Lin; Shao-Chi Chien (Bulletin of Engineering Geology and the Environment, 2020)

Two new diprenylated flavanones from Derris laxiflora Benth - Hui-Chi Huang; Shih-Chang Chien; Ching-Chuan Kuo; Ming-Der Wu; Ming-Jen Cheng; Jih-Jung Chen; Hsi-Lin Chiu; Yueh-Hsiung Kuo (Natural Product Research, 2020)

Neuroimaging Spectrum at Pre-, Early, and Late Symptomatic Stages of SCA17 Mice - Chiao-Chi Chen; Nai-Wei Yao; Chia-Wei Lin; Wei-Shuo Su; Chin-Tien Wu; Chen Chang; Hsiu Mei Hsieh-Li (The Cerebellum, 2020)

Herpud1 deficiency could reduce amyloid-β40 expression and thereby suppress homocysteine-induced atherosclerosis by blocking the JNK/AP1 pathway - Feidan Gao; Jie Zhang; Tingjuan Ni; Na Lin; Hui Lin; Hangqi Luo; Hangyuan Guo; Jufang Chi (Journal of Physiology and Biochemistry, 2020)

Household airborne endotoxin associated with asthma and allergy in elementary school-age children: a case–control study in Kaohsiung, Taiwan - Yu-Chuan Yen; Chun-Yuh Yang; Tsu-Nai Wang; Pei-Chun Yen; Chi-Kung Ho; Kristina D. Mena; Tzu-Chi Lee; Kang-Shin Chen; Yuan-Chung Lin; Pei-Shih Chen (Environmental Science and Pollution Research, 2020)
To evaluate the association between the presence of asthma and allergy, and airborne endotoxin in homes of school-age children in Kaohsiung City, Taiwan, with a case–control study design by matching the age and class exposure. Data collection of home visits included an interviewer-administered questionnaire and air sampling of participants’ homes for endotoxin, bacteria, and fungi, as well as temperature and relative humidity measurements. Endotoxin was detected in all air samples with a median value of 0.67 EU m −3 . In the adjusted logistic regression model, household airborne endotoxin was associated with higher prevalence of asthma and allergy; OR = 4.88 (95% CI 1.16–20.55) for Q3 (between 0.67 and 1.97 EU m −3 ) vs. Q1 (< 0.31 EU m −3 ), with statistical significance. Airborne fungi were associated with higher prevalence of asthma and allergy; OR = 4.47 (95% CI 1.13–17.69) for Q3 (between 314 and 699 CFU m −3 ) vs. Q1 (< 159 CFU m −3 ) in adjusted logistic regression models. Airborne endotoxin and fungi were significantly associated with children’s asthma and allergy.

Combined effect of polymorphisms of MTHFR and MTR and arsenic methylation capacity on developmental delay in preschool children in Taiwan - Yu-Mei Hsueh; Ying-Chin Lin; Chi-Jung Chung; Ya-Li Huang; Ru-Lan Hsieh; Pai-Tsang Huang; Mei-Yi Wu; Horng-Sheng Shiue; Ssu-Ning Chien; Chih-Ying Lee; Ming-I. Lin; Shu-Chi Mu; et al. (Archives of Toxicology, 2020)

The evaluation of BTEX and carbonyls emissions from recycled building materials - Yu-Hsiang Cheng; Chi-Chi Lin; Yun-Tai Lee; Yu-Chun Lin (Environmental Monitoring and Assessment, 2020)

Effects of high-frequency surface wind on the intraseasonal SST associated with the Madden-Julian oscillation - Yingxia Gao; Pang-Chi Hsu; Lin Chen; Lu Wang; Tim Li (Climate Dynamics, 2020)

Prior Antiplatelet Therapy, Excluding Phosphodiesterase Inhibitor Is Associated with Poor Outcome in Patients with Spontaneous Intracerebral Haemorrhage - Zhuo-Hao Liu; Chi-Hung Liu; Po-Hsun Tu; Ping K. Yip; Ching-Chang Chen; Yu-Chi Wang; Nan-Yu Chen; Yu-Sheng Lin (Translational Stroke Research, 2020)

Cerebellar Volume Is Associated with Cognitive Decline in Mild Cognitive Impairment: Results from ADNI - Chi-Ying Lin; Chi-Hua Chen; Sarah E. Tom; Sheng-Han Kuo (The Cerebellum, 2020)

Diverse Community Structures in the Neuronal-Level Connectome of the Drosophila Brain - Chi-Tin Shih; Yen-Jen Lin; Cheng-Te Wang; Ting-Yuan Wang; Chih-Chen Chen; Ta-Shun Su; Chung-Chuang Lo; Ann-Shyn Chiang (Neuroinformatics, 2020)

Assessing dietary exposure risk to neonicotinoid residues among preschool children in regions of Taiwan - Min-Pei Ling; Huai-An Hsiao; Szu-Chieh Chen; Wei-Yu Chen; Wei-Chun Chou; Yi-Jun Lin; Shu-Han You; Ying-Fei Yang; Hsing-Chieh Lin; Chi-Yun Chen; Tien-Hsuan Lu; Chung-Min Liao (Environmental Science and Pollution Research, 2020)

Rock mass permeability classification schemes to facilitate groundwater availability assessment in mountainous areas: a case study in Jhuoshuei river basin of Taiwan - Shih-Meng Hsu; Jun-Pu Hsu; Chien-Chung Ke; Yen-Tsu Lin; Chi-Chao Huang (Geosciences Journal, 2020)

Protective Effect of (−)Epigallocatechin-3-gallate on Rotenone-Induced Parkinsonism-like Symptoms in Rats - Hsiang-Chien Tseng; Mao-Hsien Wang; Kuo-Chi Chang; Hung-Sheng Soung; Chih-Hsiang Fang; Yi-Wen Lin; Keng-Yuan Li; Chih-Chuan Yang; Cheng-Chia Tsai (Neurotoxicity Research, 2020)

Chemical fingerprint and source apportionment of PM2.5 in highly polluted events of southern Taiwan - Huazhen Shen; Tsung-mou Yang; Chun-chung Lu; Chung-shin Yuan; Chung-Hsuang Hung; Chi-tsan Lin; Chia-wei Lee; Guohua Jing; Gongren Hu; Kuo-cheng Lo (Environmental Science and Pollution Research, 2020)

New insights into antimetastatic signaling pathways of melatonin in skeletomuscular sarcoma of childhood and adolescence - Ko-Hsiu Lu; Chiao-Wen Lin; Yi-Hsien Hsieh; Shih-Chi Su; Russel J. Reiter; Shun-Fa Yang (Cancer and Metastasis Reviews, 2020)

Mercury exposure in sedentary and migratory Charadrius plovers distributed widely across China - Tongping Su; Xin Lin; Qin Huang; Demeng Jiang; Chi Zhang; Xuecong Zhang; Caroline Dingle; Eben Goodale; Pinjia Que; Rui Wang; Yang Liu (Environmental Science and Pollution Research, 2020)

Leveraging complementary computational models for prioritizing chemicals of developmental and reproductive toxicity concern: an example of food contact materials - Chun-Wei Tung; Hsien-Jen Cheng; Chia-Chi Wang; Shan-Shan Wang; Pinpin Lin (Archives of Toxicology, 2020)

Spatiotemporal assessment of mortality attributable to ambient PM2.5 exposure in Taiwan during 2008–2015 - Su-Lun Hwang; Yu-Ching Lin; Kuang-Yu Hsiao; Chieh-Mo Lin; Miao-Ching Chi (Air Quality, Atmosphere & Health, 2020)

Resource availability affects temporal variation of phytoplankton size structure in the Kuroshio east of Taiwan - Fan‐Sian Lin; Pei‐Chi Ho; Akash R. Sastri; Chung‐Chi Chen; Gwo‐Ching Gong; Sen Jan; Chih‐hao Hsieh (Limnology and Oceanography, 2020)
The on‐going discussion concerning how environmental factors determine phytoplankton size structure has centered around two hypotheses: (H1) The resource‐size relationship predicts that normalized biovolume size spectrum (NBSS) slopes for phytoplankton are progressively shallower with increasing resource availability and (H2) The temperature‐size relationship predicts that phytoplankton NBSS slopes steepen with increasing water temperature. To test these hypotheses, we examined 72 phytoplankton assemblage collections in the Kuroshio east of Taiwan. Total phytoplankton biomass was used as a proxy for resource availability instead of nutrients because nutrients are depleted and do not represent resource availability for oligotrophic seas. We found no significant relationship between NBSS slopes with temperature, providing little support for the temperature‐size rule. In contrast, a positive relationship between NBSS slopes and total biomass for most of the year lends general support to the resource‐size relationship, except during the winter and early spring. To explain this exception, we hypothesize that resource pulses occurring during the cold seasons are used more efficiently by small cells and promote faster growth of small relative to large phytoplankton because these pulses take place after a long period of resource depletion in oligotrophic seas; thus, the NBSS slopes become much steeper than would be expected from a positive resource‐size relationship. This deviation can be considered as nonsteady state in terms of phytoplankton size structure relative to resources. Nevertheless, we cannot rule out the possibility that grazing effects also play an important role in controlling phytoplankton size structure.

Applying Iterative Method to Solving High-Order Terms of Seafloor Topography - Diao Fan; Shanshan Li; Shuyu Meng; Yi Lin; Zhibin Xing; Chi Zhang; Junjun Yang; Xiaoyun Wan; Zhenhao Qu (Marine Geodesy, 2020)

Methamphetamine-Induced Cognitive Deficits and Psychiatric Symptoms Are Associated with Serum Markers of Liver Damage - Tingting Zhao; Changping Zhai; Hongmei Song; Yanhai Wu; Chuanhui Ge; Yonglin Zhang; Hongxia Xu; Zhengsuo Chi; Hui Chu; Wei Shi; Xiaodong Cheng; Xin Li; et al. (Neurotoxicity Research, 2020)

Gallic Acid Attenuated LPS-Induced Neuroinflammation: Protein Aggregation and Necroptosis - Yu-Ling Liu; Chia-Chi Hsu; Hui-Ju Huang; Chih-Jung Chang; Shu-Hui Sun; Anya Maan-Yuh Lin (Molecular Neurobiology, 2020)

Anti-inflammatory Effect of AZD6244 on Acrolein-Induced Neuroinflammation - Wen-Chien Ho; Chia-Chi Hsu; Hui-Ju Huang; Hsiang-Tsui Wang; Anya Maan-Yuh Lin (Molecular Neurobiology, 2020)

Sarocladium species associated with rice in Taiwan - Jie-Hao Ou; Guo-Cih Lin; Chi-Yu Chen (Mycological Progress, 2020)

Correction to: Soluble Epoxide Hydrolase Inhibition Attenuates Excitotoxicity Involving 14,15-Epoxyeicosatrienoic Acid–Mediated Astrocytic Survival and Plasticity to Preserve Glutamate Homeostasis - Yi-Min Kuo; Pei-Chien Hsu; Chia-Chi Hung; Ya-Yu Hu; Yu-Jie Huang; Yu-Ling Gan; Chun-Hua Lin; Feng-Shiun Shie; Wen-Kuei Chang; Lung-Sen Kao; Mei-Yung Tsou; Yi-Hsuan Lee (Molecular Neurobiology, 2019)

Soluble Epoxide Hydrolase Inhibition Attenuates Excitotoxicity Involving 14,15-Epoxyeicosatrienoic Acid–Mediated Astrocytic Survival and Plasticity to Preserve Glutamate Homeostasis - Yi-Min Kuo; Pei-Chien Hsu; Chia-Chi Hung; Ya-Yu Hu; Yu-Jie Huang; Yu-Ling Gan; Chun-Hua Lin; Feng-Shiun Shie; Wen-Kuei Chang; Lung-Sen Kao; Mei-Yung Tsou; Yi-Hsuan Lee (Molecular Neurobiology, 2019)

Mutational signatures and mutagenic impacts associated with betel quid chewing in oral squamous cell carcinoma - Shih-Chi Su; Lun-Ching Chang; Chiao-Wen Lin; Mu-Kuan Chen; Chun-Ping Yu; Wen-Hung Chung; Shun-Fa Yang (Human Genetics, 2019)

Pathological and therapeutic aspects of matrix metalloproteinases: implications in childhood leukemia - Yi-Hsuan Hsiao; Shih-Chi Su; Chiao-Wen Lin; Yu-Hua Chao; Wei-En Yang; Shun-Fa Yang (Cancer and Metastasis Reviews, 2019)

Seasonal precipitation change in the Western North Pacific and East Asia under global warming in two high-resolution AGCMs - Chao-An Chen; Huang-Hsiung Hsu; Chi-Cherng Hong; Ping-Gin Chiu; Chia-Ying Tu; Shian-Jiann Lin; Akio Kitoh (Climate Dynamics, 2019)

Rapamycin Removes Damaged Mitochondria and Protects Human Trabecular Meshwork (TM-1) Cells from Chronic Oxidative Stress - Jing Na He; Shao Dan Zhang; Yang Qu; Hai Lin Wang; Clement C. Tham; Chi Pui Pang; Wai Kit Chu (Molecular Neurobiology, 2019)

Association of plasma folate, vitamin B12 levels, and arsenic methylation capacity with developmental delay in preschool children in Taiwan - Ying-Chin Lin; Chi-Jung Chung; Ya-Li Huang; Ru-Lan Hsieh; Pai-Tsang Huang; Mei-Yi Wu; Pui-Lam Ao; Horng-Sheng Shiue; Shiau-Rung Huang; Chien-Tien Su; Ming-I Lin; Shu-Chi Mu; et al. (Archives of Toxicology, 2019)

Steroid-Enriched Fraction of Achyranthes bidentata Protects Amyloid β Peptide 1–40-Induced Cognitive Dysfunction and Neuroinflammation in Rats - Li-Wei Lin; Fan-Hsuan Tsai; Wan-Cheng Lan; Yih-Dih Cheng; Sheng-Chi Lee; Chi-Rei Wu (Molecular Neurobiology, 2019)

Impaired autophagy mediates hyperhomocysteinemia-induced HA-VSMC phenotypic switching - Tingjuan Ni; Feidan Gao; Jie Zhang; Hui Lin; Hangqi Luo; Jufang Chi; Hangyuan Guo (Journal of Molecular Histology, 2019)

Progressive multifocal leukoencephalopathy in a renal transplant patient - Tsu-Chen Lin; Mei-Yi Wu; Hui-Tzung Luh; Shiou-Fu Lin; Chien-Min Lin; Ying-Chi Tseng; Yung-Ching Liu; Mai-Szu Wu (Journal of NeuroVirology, 2019)

Characterization of the endonuclease activity of the replication-associated protein of beak and feather disease virus - Jui-Kai Chen; Chiaolong Hsiao; Jian-Shin Wu; Shin-Yi Lin; Chi-Young Wang (Archives of Virology, 2019)

Using a numerical method to precisely evaluate the alpha angle in a hip image - Chung-Liang Lai; Wei-Min Chi; Ying-Jui Ho; Chien-Chung Lin; Hsiao-Che Lin; Chin-Liang Kuo; Jian-Horng Chen (Medical & Biological Engineering & Computing, 2019)

Preparation of AgCl/TNTs nanocomposites for organic dyes and inorganic heavy metal removal - Cheng-Yen Tsai; Chen-Wuing Liu; Hsing-Cheng Hsi; Kuen-Song Lin; Yi-Wen Lin; Li-Chi Lai; Tsung-Nan Weng (Environmental Science and Pollution Research, 2019)

Removal of chlorpheniramine and variations of nitrosamine formation potentials in municipal wastewaters by adsorption onto the GO-Fe3O4 - Chih-Hsien Lin; Chi-Min Li; Chun-Hu Chen; Wei-Hsiang Chen (Environmental Science and Pollution Research, 2019)

Quantitative phosphoproteomic analyses provide evidence for extensive phosphorylation of regulatory proteins in the rhizobia–legume symbiosis - Zaibao Zhang; Danxia Ke; Menghui Hu; Chi Zhang; Lijun Deng; Yuting Li; Jiuli Li; Hai Zhao; Lin Cheng; Lei Wang; Hongyu Yuan (Plant Molecular Biology, 2019)

An Adult Drosophila Glioma Model for Studying Pathometabolic Pathways of Gliomagenesis - Kuan-Cheng Chi; Wen-Chiuan Tsai; Chia-Lin Wu; Tzu-Yang Lin; Dueng-Yuan Hueng (Molecular Neurobiology, 2019)

Modeling Alzheimer’s Disease by Induced Pluripotent Stem Cells Carrying APP D678H Mutation - Kuo-Hsuan Chang; Guey-Jen Lee-Chen; Ching-Chang Huang; Jia-Li Lin; Yi-Jing Chen; Pei-Chi Wei; Yen-Shi Lo; Chin-Fa Yao; Ming-Wei Kuo; Chiung-Mei Chen (Molecular Neurobiology, 2019)

PARK14 (D331Y) PLA2G6 Causes Early-Onset Degeneration of Substantia Nigra Dopaminergic Neurons by Inducing Mitochondrial Dysfunction, ER Stress, Mitophagy Impairment and Transcriptional Dysregulation in a Knockin Mouse Model - Ching-Chi Chiu; Chin-Song Lu; Yi-Hsin Weng; Ying-Ling Chen; Ying-Zu Huang; Rou-Shayn Chen; Yi-Chuan Cheng; Yin-Cheng Huang; Yu-Chuan Liu; Szu-Chia Lai; Kun-Jun Lin; Yan-Wei Lin; et al. (Molecular Neurobiology, 2019)

Transcription Factor 2I Regulates Neuronal Development via TRPC3 in 7q11.23 Disorder Models - Marielle H. S. Deurloo; Ekaterina Turlova; Wen-Liang Chen; You Wei Lin; Elaine Tam; Nardos G. Tassew; Michael Wu; Ya-Chi Huang; Jacqueline N. Crawley; Philippe P. Monnier; Alexander J. A. Groffen; Hong-Shuo Sun; et al. (Molecular Neurobiology, 2019)

Cover Image - Theeraporn Pulpipat; Kuo‐Hua Lin; Ying‐Hao Chen; Pei‐Chi Wang; Shih‐Chu Chen (Journal of Fish Diseases, 2019)

Molecular characterization and pathogenicity of Francisella noatunensis subsp. orientalis isolated from cultured tilapia ( Oreochromis sp.) in Taiwan - Theeraporn Pulpipat; Kuo‐Hua Lin; Ying‐Hao Chen; Pei‐Chi Wang; Shih‐Chu Chen (Journal of Fish Diseases, 2019)
Francisella noatunensis subsp. orientalis is a causative agent of systemic granulomatous disease in tilapia. The present study was designed to understand the genetic and phenotypic diversities among Taiwanese Fno isolates obtained from tilapia ( n = 17) and green Texas cichlid ( Herichthys cyanoguttatus ) ( n = 1). The enzymatic profiles of the isolates were studied using the API ZYM system. Phylogenetic tree analysis of the 16S rRNA and housekeeping gene and pulsed‐field gel electrophoresis (PFGE) were carried out to determine the genotypic characters of all isolates. The phylogenetic tree showed similarity of 99%–100% nucleotide sequences of 16S rRNA and housekeeping genes compared to the Fno references genes from GenBank database. Comparatively, the results revealed an identical profile of enzymatic and PFGE pattern which was distincted from that of F. philomiragia . To understand the pathogenicity, the isolates were intraperitoneal injected to tilapia the gross lesions were observed concomitant with natural outbreak. Median lethal dose upon Nile tilapia and red tilapia were 9.06 × 10 3 CFU/fish and 2.08 × 10 2 CFU/fish, respectively. Thus, our data provide understanding the epidemiology of Taiwanese Fno isolates, and help in development of future control and prevention.

Structural Properties of the San Jacinto Fault Zone at Blackburn Saddle from Seismic Data of a Dense Linear Array - Pieter-Ewald Share; Amir A. Allam; Yehuda Ben-Zion; Fan-Chi Lin; Frank L. Vernon (Pure and Applied Geophysics, 2019)

Genome-wide analysis identified 17 new loci influencing intraocular pressure in Chinese population - Lulin Huang; Yuhong Chen; Ying Lin; Pancy O. S. Tam; Yilian Cheng; Yi Shi; Bo Gong; Fang Lu; Jialiang Yang; Haixin Wang; Yi Yin; Yong Cao; et al. (Science China Life Sciences, 2019)

Benefit analysis of flood adaptation under climate change scenario - Hsin-Chi Li; Shih-Yun Kuo; Wei-Bo Chen; Lee-yaw Lin (Natural Hazards, 2019)

Effects of a Web-based Health Education Program on Quality of Life and Symptom Distress of Initially Diagnosed Advanced Non-Small Cell Lung Cancer Patients: A Randomized Controlled Trial - Chi-Chin Huang; Han-Pin Kuo; Yueh-E Lin; Shu-Ching Chen (Journal of Cancer Education, 2019)

Numerical assessments of recharge-dominated groundwater flow and transport in the nearshore reclamation area in western Taiwan - Chuen-Fa Ni; Wei-Ci Li; Shaohua Marko Hsu; I-Hsien Lee; Chi-Ping Lin (Environmental Monitoring and Assessment, 2019)

Sigma-1 receptor protects against endoplasmic reticulum stress-mediated apoptosis in mice with cerebral ischemia/reperfusion injury - Xuemei Zhao; Lin Zhu; Danyang Liu; Tianyan Chi; Xuefei Ji; Peng Liu; Xuexue Yang; Xinxin Tian; Libo Zou (Apoptosis, 2019)

Exercise Rehabilitation Attenuates Cognitive Deficits in Rats with Traumatic Brain Injury by Stimulating the Cerebral HSP20/BDNF/TrkB Signalling Axis - Willy Chou; Yu-Fan Liu; Cheng-Hsien Lin; Mao-Tsun Lin; Chi-Chun Chen; Wen-Pin Liu; Ching-Ping Chang; Chung-Ching Chio (Molecular Neurobiology, 2018)

In vitro assessment of the toxicity of small silver nanoparticles and silver ions to the red blood cells - Zhenxing Chi; Hongwei Lin; Weiguo Li; Xunuo Zhang; Qiang Zhang (Environmental Science and Pollution Research, 2018)

Response to “Letter to the editor re: Cheng YH, Chou WC, Yang YF, et al. Environ Sci Pollut Res (2018). https://doi.org/10.107/s11356-017-0875-4” - Yi-Hsien Cheng; Wei-Chun Chou; Ying-Fei Yang; Chi-Wei Huang; Chun Ming How; Szu-Chieh Chen; Wei-Yu Chen; Nan-Hung Hsieh; Yi-Jun Lin; Shu-Han You; Chung-Min Liao (Environmental Science and Pollution Research, 2018)

Analysis of the Aso-Bridge landslide during the 2016 Kumamoto earthquakes in Japan - Ching Hung; Guan-Wei Lin; Huei-Sian Syu; Chi-Wen Chen; Hsin-Yi Yen (Bulletin of Engineering Geology and the Environment, 2018)

Dendrocoumarin: a new benzocoumarin derivative from the stem of Dendrobium nobile - Xue-Ming Zhou; Bin Zhang; Guang-Ying Chen; Chang-Ri Han; Kun-Chi Jiang; Ming-Yue Luo; Bo-Zheng Meng; Wen-Xin Li; Shi-Dai Lin (Natural Product Research, 2018)

The effects of El Niño‐Southern Oscillation events on intertidal seagrass beds over a long‐term timescale - Hsing‐Juh Lin; Chen‐Lu Lee; Shang‐En Peng; Meng‐Chi Hung; Pi‐Jen Liu; Anderson B. Mayfield (Global Change Biology, 2018)
El Niño‐Southern Oscillation (ENSO) events can cause dramatic changes in marine communities. However, we know little as to how ENSO events affect tropical seagrass beds over decadal timescales. Therefore, a diverse array of seagrass ( Thalassia hemprichii ) habitat types were surveyed once every 3 months for 16 years (January 2001 to February 2017) in a tropical intertidal zone that is regularly affected by both ENSO events and anthropogenic nutrient enrichment. La Niña and El Niño events had distinct effects on the biomass and growth of T. hemprichii . During La Niña years, higher (a) precipitation levels and (b) seawater nitrogen concentrations led to increases in seagrass leaf productivity, canopy height, and biomass. However, the latter simultaneously stimulated the growth of periphyton on seagrass leaves; this led to decreases in seagrass cover and shoot density. More frequent La Niña events could, then, eventually lead to either a decline in intertidal seagrass beds or a shift to another, less drought‐resistant seagrass species in those regions already characterized by eutrophication due to local anthropogenic activity.

Dynamic response of a dip slope with multi-slip planes revealed by shaking table tests - Hung-Hui Li; Cheng-Han Lin; Wei Zu; Chi-Chieh Chen; Meng-Chia Weng (Landslides, 2018)

Assessing the population transmission dynamics of tilapia lake virus in farmed tilapia - Ying‐Fei Yang; Tien‐Hsuan Lu; Hsing‐Chieh Lin; Chi‐Yun Chen; Chung‐Min Liao (Journal of Fish Diseases, 2018)
A novel virus, tilapia lake virus (Ti LV ), has been identified as a key pathogen responsible for disease outbreak and mass mortality of farmed tilapia. We used a deterministic susceptible‐infectious‐mortality ( SIM ) model to derive key disease information appraised with published Ti LV ‐induced cumulative mortality data. The relationship between tilapia mortality and Ti LV exposure dosages was described by the Hill model. Furthermore, a disease control model was proposed to determine the status of controlled Ti LV infection using a parsimonious control reproduction number ( R C )‐control line criterion. Results showed that the key disease determinants of transmission rate and basic reproduction number ( R 0 ) could be derived. The median R 0 estimate was 2.59 in a cohabitation setting with 2.6 × 10 5 TCID 50 fish −1 Ti LV . The present R C ‐control model can be employed to determine whether Ti LV containment is feasible in an outbreak farm by quantifying the current level of transmission. The SIM model can then be applied to predict what additional control is required to manage R C

Reach and messages of the world's largest ivory burn - Alexander Braczkowski; Matthew H. Holden; Christopher O'Bryan; Chi‐Yeung Choi; Xiaojing Gan; Nicholas Beesley; Yufang Gao; James Allan; Peter Tyrrell; Daniel Stiles; Peadar Brehony; Revocatus Meney; et al. (Conservation Biology, 2018)
Recent increases in ivory poaching have depressed African elephant populations. Successful enforcement has led to ivory stockpiling. Stockpile destruction is becoming increasingly popular, and most destruction has occurred in the last 5 years. Ivory destruction is intended to send a strong message against ivory consumption, both in promoting a taboo on ivory use and catalyzing policy change. However, there has been no effort to establish the distribution and extent of media reporting on ivory destruction events globally. We analyzed media coverage of the largest ivory destruction event in history (Kenya, 30 April 2016) across 11 nation states connected to ivory trade. We used an online‐media crawling tool to search online media outlets and subjected 5 of the largest print newspapers (by circulation) in 5 nations of interest to content analysis. Most online news on the ivory burn came from the United States (81% of 1944 articles), whereas most of the print news articles came from Kenya (61% of 157 articles). Eighty‐six to 97% of all online articles reported the burn as a positive conservation action, whereas 4–50% discussed ivory burning as having a negative impact on elephant conservation. Most articles discussed law enforcement and trade bans as effective for elephant conservation. There was more relative search interest globally in the 2016 Kenyan ivory burn than any other burn in 5 years. Ours is the first attempt to track the reach of media coverage relative to an ivory burn and provides a case study in tracking the effects of a conservation‐marketing event.

Sodium Metabisulfite: Effects on Ionic Currents and Excitotoxicity - Ming-Chi Lai; Te-Yu Hung; Kao-Min Lin; Pi-Shan Sung; Shyh-Jong Wu; Chih-Sheng Yang; Yi-Jen Wu; Jing-Jane Tsai; Sheng-Nan Wu; Chin-Wei Huang (Neurotoxicity Research, 2018)

D-Cycloserine Ameliorates Autism-Like Deficits by Removing GluA2-Containing AMPA Receptors in a Valproic Acid-Induced Rat Model - Han-Fang Wu; Po See Chen; Ya-Ting Hsu; Chi-Wei Lee; Tzu-Feng Wang; Yi-Ju Chen; Hui-Ching Lin (Molecular Neurobiology, 2018)

Peri-Therapeutic Quantitative Flow Analysis of Endovascular Revascularization for Ischemic Stroke Patients on Digital Subtraction Angiography - Shih-Neng Yang; Yu-Yi Lin; Tsung-Jung Ho; Shi-Yann Cheng; Yu-Rou Chiou; Chun-Han Liao; Geoffrey G. Zhang; Tzung-Chi Huang (Journal of Medical and Biological Engineering, 2018)