Carbon-based and carbon-supported nanomaterials for the catalytic conversion of biomass: a review - Dong Xia; Huayang Yu; Heng Li; Peng Huang; Qun Li; Yuanpeng Wang (Environmental Chemistry Letters, 2022)

DNA aptamers specific for Legionella pneumophila: systematic evolution of ligands by exponential enrichment in whole bacterial cells - Lina Xiong; Mingchen Xia; Qinglin Wang; Zhen Meng; Jie Zhang; Guohui Yu; Zhangyong Dong; Yongjun Lu; Yunhao Sun (Biotechnology Letters, 2022)

Evaluation of Chito-Oligosaccharide (COS) in Vitro and in Vivo: Permeability Characterization in Caco-2 Cells Monolayer and Pharmacokinetics Properties in Rats - Pengpeng Zhang; Miaomiao Zhang; Kaiyu Dong; Yicong Zhang; Shuang Yang; Yuanhong Wang; Tingfu Jiang; Mingming Yu; Zhihua Lv (Journal of Ocean University of China, 2022)

Updating a New Semi-nested PCR Primer Pair for the Specific Detection of GII Norovirus in Oysters - Lei Dong; Tianhui Jia; Yongxin Yu; Yongjie Wang (Food and Environmental Virology, 2022)

Unsaturated soil deformation theory and test verification based on the catastrophe model - Xiao-wen Liu; Wen-dong Wang; Yu Shi (Arabian Journal of Geosciences, 2022)

Evaluation of Arctic Sea Ice Drift and its Relationship with Near-surface Wind and Ocean Current in Nine CMIP6 Models from China - Xiaoyong Yu; Chengyan Liu; Xiaocun Wang; Jian Cao; Jihai Dong; Yu Liu (Advances in Atmospheric Sciences, 2022)

Optimization of aquaculture sustainability through ecological intensification in China - Shuang‐lin Dong; Yun‐wei Dong; Ling Cao; Johan Verreth; Yngvar Olsen; Wen‐jing Liu; Qi‐zhi Fang; Yan‐gen Zhou; Li Li; Jing‐yu Li; Yong‐tong Mu; Patrick Sorgeloos (Reviews in Aquaculture, 2022)
As the world's leading producer of farmed aquatic food products, China faces great uncertainty concerning the further sustainable development of its aquaculture industry due to high and increasing pressure from environmental and resource constraints. To realize truly sustainable development, it is imperative to establish an evaluation system that integrates social, economic, environmental and resource criteria, and optimizes aquaculture systems through a holistic approach. Here, we used analytical hierarchy processes combined with expert judgment and objective data to assess the sustainability of 10 major aquaculture production systems (APSs) in China. Based on the evaluation results, we propose the ecological intensification of aquaculture systems (ELIAS), rationally integrating anthropogenic inputs with aquaculture ecosystem services, to improve the sustainability of APSs. The holistic evaluation system and ELIAS are fundamental and critical for the future development of aquaculture in China and globally.

Cover Image, Volume 14, Issue 3 - Shuang‐lin Dong; Yun‐wei Dong; Ling Cao; Johan Verreth; Yngvar Olsen; Wen‐jing Liu; Qi‐zhi Fang; Yan‐gen Zhou; Li Li; Jing‐yu Li; Yong‐tong Mu; Patrick Sorgeloos (Reviews in Aquaculture, 2022)
The cover image is based on the Review Article Optimization of aquaculture sustainability through ecological intensification in China by Shuang‐lin Dong et al., https://doi.org/10.1111/raq.12648 image

A Discontinuous Individual Growth Model of Swimming Crab Portunus trituberculatus and Its Application in the Nutrient Dynamic Simulation in an Intensive Mariculture Pond - Shipeng Dong; Xian Xu; Fan Lin; Liye Yu; Hongwei Shan; Fang Wang (Frontiers in Marine Science, 2022)
Environmental problems such as organic pollution and eutrophication caused by highly intensive mariculture activities constrain the sustainable and healthy development of industry. Therefore, it is necessary to quantify the nutrient dynamics of aquaculture animals in order to reduce the risk of environmental pollution. In this study, a discontinuous individual growth model of Portunus trituberculatus in an intensive mariculture pond of P. trituberculatus – Penaeus japonicus – Sinonovacula constricta was constructed based on a dynamic energy budget theory combined with the index of condition factor. This model better predicted the growth and molting behavior of P. trituberculatus , and an acceptable fit was obtained through model parameterization using the Add-my-Pet (AmP) method (mean relative error = 0.058, symmetric mean squared error = 0.007). Ten molts were simulated over 180 days and generally coincided with the recorded molt time points. Based on this model and P. trituberculatus populations, the dynamic processes of carbon, nitrogen, and phosphorus in ingestion, respiration, excretion, feces, residual feed, dead crabs, seeding, molt, and harvest were simulated. The carbon, nitrogen, and phosphorus ingested during the 180-day culture period were 4,938.57 kg ha -1 , 1,255.88 kg ha -1 , and 244.16 kg ha -1 , respectively. Carbon, nitrogen, and phosphorus removal by harvest accounted for 1.06%, 1.03% and 0.62% of the total ingestion, respectively, while carbon, nitrogen, and phosphorus removal by dead crabs accounted for 6.84%, 6.63%, and 4.04%, respectively, and carbon, nitrogen, and phosphorus released from residual feed into the water accounted for 41.43% of the total feed. The accurate simulation of molting behavior and nutrient dynamics in this study provides a theoretical basis for molting risk prevention and environmental stress assessment of P. trituberculatus and provides basic modules and data support for the construction of the integrated mariculture ecosystem model.

Multiple Lenses of N-Isotopes Reveal Active Dissolved Organic Nitrogen Cycling in a Subtropical Estuary and Marginal Sea - Xiaosong Zhong; Maojun Yan; Wenqi Xu; Zhenwei Yan; Feng Xu; Shuhang Dong; Yu Xin; Xiaoyong Shi (Frontiers in Marine Science, 2022)
Dissolved organic nitrogen (DON) is an important component of the marine nitrogen (N) inventory and plays an essential role in N cycling in global estuaries and marginal seas. Understanding DON cycling is important but challenging. Global estuaries and marginal seas are experiencing significant anthropogenic impacts and have intensive physical/biochemical gradients. Therefore, high-quality DON concentration and N-isotope (δ 15 N–DON) data are very difficult to obtain. To enrich this knowledge, we take the Changjiang Estuary and the adjacent East China Sea shelf seas as a representative example and analyzed multiple isotopes and the concentrations of nitrate ( N O 3 − ), particulate nitrogen (PN), and DON. N isotopes combined with optimum multiparameter analysis proved to be very informative. This integrated analysis discriminates active DON production and consumption from a seemingly conservative distribution pattern of DON. The study area was divided into DON production zones 1 and 2 (P-zone 1 and 2) and DON consumption zones 1 and 2 (C-zone 1 and 2). For P-zone 1, the PN-originated DON elevated the δ 15 N–DON, while in P-zone 2, the DON excreted by phytoplankton was characterized by low δ 15 N and lowered δ 15 N–DON. DON consumption occurred in the N O 3 − depleted surface waters (C-zone 1) as well as the shelf middle and bottom waters (C-zone 2). This study discovers and consolidates the active and dynamical zoning of DON cycling from the estuary to the offshore marginal sea and establishes a useful means that is of valuable reference to DON cycling studies in global estuaries and marginal seas.

A new highly oxygenated germacranolide from Carpesium nepalense var. lanatum (C.B.Clarke) Kitam - Yi-Fan Yu; Yue-Qian Li; Ru-Yue Wang; Xu Liu; Wen-Bo Cui; Xiao-Han Chen; Cheng-Mu Zhao; Feng-Ming Qi; Zhan-Xin Zhang; Dong-Qing Fei (Natural Product Research, 2022)

Quasi-Synchronous Accumulation of Apparent Oxygen Utilization and Inorganic Carbon in the South Yellow Sea Cold Water Mass From Spring to Autumn: The Acidification Effect and Roles of Community Metabolic Processes, Water Mixing, and Spring Thermal State - Si-qing Yu; Tian-qi Xiong; Wei-dong Zhai (Frontiers in Marine Science, 2022)
To better understand seasonal acidification in the South Yellow Sea (SYS), four field surveys conducted in 2019 and the historical data obtained in 2018 were incorporated in this study. The lowest aragonite saturation state (Ω arag ) value of 1.15 was observed in the central SYS in late autumn. Despite interannual variations in the rate of net community respiration, the quasi-synchronous accumulation of apparent oxygen utilization and excess dissolved inorganic carbon (DIC) relative to the air equilibrium were revealed in the SYS cold water mass (SYSCWM) from late spring to autumn. Correspondingly, the two acidification indexes (Ω arag and pH) decreased in logarithmic forms in the SYSCWM in warm seasons. To examine the potential influences of hydrological dynamics on seasonal acidification in the SYSCWM, a three-endmember water-mixing model was applied. The results showed that the cumulative effect of various non-conservative processes on DIC was comparable with the excess DIC relative to the air equilibrium. This implied that the summer and autumn carbonate dynamics and the acidification status of the cold water mass were almost free from the potential impacts of the weak water mixing and internal circulation in summer and autumn in a given year. The Yellow Sea Warm Current carries oceanic DIC into the SYS only in winter and early spring. This study also showed that the re-equilibrium with atmospheric CO 2 at given temperature in early spring determined the initial Ω arag of the SYS before Ω arag declining in late spring, summer, and autumn. The sensitivity of coastal Ω arag changes to DIC addition is subject to both spatial and temporal variations.

The kinesin-13 protein BR HYPERSENSITIVE 1 is a negative brassinosteroid signaling component regulating rice growth and development - Yanli Zhang; Guojun Dong; Fei Chen; Erhui Xiong; Huijie Liu; Yaohuang Jiang; Guosheng Xiong; Banpu Ruan; Qian Qian; Dali Zeng; Dianrong Ma; Yanchun Yu; et al. (Theoretical and Applied Genetics, 2022)

Kai-Xin-San Inhibits Tau Pathology and Neuronal Apoptosis in Aged SAMP8 Mice - Ya-Nan Jiao; Jing-Sheng Zhang; Wen-Jun Qiao; Shu-Yu Tian; Yi-Bin Wang; Chun-Yan Wang; Yan-Hui Zhang; Qi Zhang; Wen Li; Dong-Yu Min; Zhan-You Wang (Molecular Neurobiology, 2022)
Alzheimer’s disease (AD) is an age-related neurological disorder. Currently, there is no effective cure for AD due to its complexity in pathogenesis. In light of the complex pathogenesis of AD, the traditional Chinese medicine (TCM) formula Kai-Xin-San (KXS), which was used for amnesia treatment, has been proved to improve cognitive function in AD animal models. However, the active ingredients and the mechanism of KXS have not yet been clearly elucidated. In this study, network pharmacology analysis predicts that KXS yields 168 candidate compounds acting on 863 potential targets, 30 of which are associated with AD. Enrichment analysis revealed that the therapeutic mechanisms of KXS for AD are associated with the inhibition of Tau protein hyperphosphorylation, inflammation, and apoptosis. Therefore, we chose 7-month-old senescence-accelerated mouse prone 8 (SAMP8) mice as AD mouse model, which harbors the behavioral and pathological hallmarks of AD. Subsequently, the potential underlying action mechanisms of KXS on AD predicted by the network pharmacology analyses were experimentally validated in SAMP8 mice after intragastric administration of KXS for 3 months. We observed that KXS upregulated AKT phosphorylation, suppressed GSK3β and CDK5 activation, and inhibited the TLR4/MyD88/NF-κB signaling pathway to attenuate Tau hyperphosphorylation and neuroinflammation, thus suppressing neuronal apoptosis and improving the cognitive impairment of aged SAMP8 mice. Taken together, our findings reveal a multi-component and multi-target therapeutic mechanism of KXS for attenuating the progression of AD, contributing to the future development of TCM modernization, including KXS, and broader clinical application. Graphical abstract

Cultivation of gut microorganisms of the marine ascidian Halocynthia roretzi reveals their potential roles in the environmental adaptation of their host - Yang Yang; Yuting Zhu; Haiming Liu; Jiankai Wei; Haiyan Yu; Bo Dong (Marine Life Science & Technology, 2022)
It has long been known that abundant symbiotic bacteria exist in the tunic and gut of marine ascidians, and that these play crucial roles in host development, physiological metabolism, and environmental adaptation. However, the identity, roles and functions of these symbiotic bacteria are known for only a few strains. In this study, we isolated and cultivated 263 strains of microorganisms from the intestine of the marine ascidian Halocynthia roretzi through a combination of aerobic and anaerobic culture approaches. Most cultivated species, both aerobic and anaerobic, from ascidian stool samples belonged to the genus Bacillus based on 16S rDNA sequencing identification and phylogenetic assays. The distribution of cultured bacteria varied with seasonal changes in environmental conditions. To explore the functions of cultured bacteria, we screened out a strain of Serratia sp. whose extracts showed high antibacterial activity against aquatic pathogens. These findings revealed the potential roles of gut microorganisms in ascidian defense and environmental adaptation, thus providing insights into the interaction and co-evolution between gut bacteria and their hosts.

Comparative transcriptomics and multiple phytohormone profiling reveals the molecular immune response of Arabidopsis thaliana to the pathogen Ralstonia solanacearum type III effector RipN - Zhangyong Dong; Xiaoying Zheng; Yongxin Shu; Zhen Meng; Jie Zhang; Lina Xiong; Ping Cheng; Guohui Yu; Yunhao Sun (Journal of Plant Pathology, 2022)

Renal tubule ectopic lipid deposition in diabetic kidney disease rat model and in vitro mechanism of leptin intervention - Shasha Liu; Jingjing Da; Jiali Yu; Rong Dong; Jing Yuan; Fuxun Yu; Yan Zha (Journal of Physiology and Biochemistry, 2022)

Low-field nuclear magnetic resonance detection of changes in the water distribution in citric acid biosludge during dewatering - Y. F. Liu; L. M. Dong; G. N. Cui; X. Y. Hu; Z. Q. Yu; S. Liang (International Journal of Environmental Science and Technology, 2022)

Oxalic acid activated bone meal for immobilization of Pb and Cd contaminated soils - Yi-Zhao Liu; Ri-Dong Fan; Song-Yu Liu; Huan He (Environmental Science and Pollution Research, 2022)

Stable Isotopes Reveal Water Vapor Sources of Precipitation over the Jiaolai Plain, Shandong Peninsula, China - Ying Wang; Bu-li Cui; Dong-sheng Li; Ya-xuan Wang; Wan-xin Yu; He-hua Zong (Asia-Pacific Journal of Atmospheric Sciences, 2022)

Genome-based reclassification of the genus Meiothermus along with the proposal of a new genus Allomeiothermus gen. nov - Jian-Yu Jiao; Zheng-Han Lian; Ze-Tao Liu; Lan Liu; Meng-Meng Li; Ai-Ping Lv; Wen-Dong Xian; Ting Zhou; Zhitang Lyu; Nimaichand Salam; Wen-Jun Li (Antonie van Leeuwenhoek, 2022)

Short-term variations and influencing factors of suspended sediment concentrations at the Heisha Beach, Guangdong, China - Jintang Ou; Haoyan Dong; Liangwen Jia; Xiangxin Luo; Zixiao He; Kanglin Chen; Jing Liu; Yitong Lin; Mingdong Yu; Mingen Liang (Acta Oceanologica Sinica, 2022)

Filter-Feeding Bivalve Weakens Food Competition Between Crustaceans (Portunus trituberculatus, Marsupenaeus japonicus) in Integrated Culture Ponds: Evidence From 18S rDNA Barcoding and Stable Isotope Analysis - Xian Xu; Shipeng Dong; Dongxu Zhang; Liye Yu; Weijia Pu; Yicheng Xie; Hongwei Shan; Fang Wang (Frontiers in Marine Science, 2022)
In order to investigate the effects of razor clams ( Sinonovacula constricta ) on the food composition and isotopic niches of swimming crabs ( Portunus trituberculatus ) and kuruma shrimp ( Marsupenaeus japonicus ) in polyculture systems, this study analyzed 60 P . trituberculatus , 60 M. japonicus and 30 S. constricta to quantify the food sources, food source contributions, and isotopic niches of cultured organisms using 18S rDNA barcoding and stable isotope techniques. The results were as follows: (1) In the P. trituberculatus - M. japonicus (PM) polyculture system, the Sobs and Shannon-Wiener indices of the stomach contents of P. trituberculatus and M. japonicus were not significantly different ( P > 0.05). In the P. trituberculatus - M. japonicus - S. constricta polyculture (PMS) system, the Sobs and Shannon-Wiener indices of the stomach contents of P. trituberculatus and M. japonicus were also not significantly different ( P > 0.05), but the Sobs indices of P. trituberculatus in the PMS system were significantly higher than those in the PM system ( P < 0.05), M. japonicus shows a similar pattern. (2) 18S rDNA barcoding analysis showed the dominant taxa in the stomach contents of both P. trituberculatus and M. japonicus in the PM system were Trebouxiophyceae, Embryophyta and Rotifera, and the food overlap between them was 0.8992, which was significant (Q > 0.6). In the PMS system, the dominant taxa in the stomach contents of P. trituberculatus were Chrysophyceae, Intramacronucleata, and Embryophyta, and in M. japonicus were Chrysophyceae, Embryophyta, and Bacillariophyceae, in this system the food overlap was 0.2061, which was not significant (Q < 0.6). (3) Stable isotope analysis suggested, in both systems, the main food sources of P. trituberculatus and M. japonicus were iced trash fish, zooplankton, phytoplankton, and organic particulate matter (POM). Iced trash fish accounted 77.67% of food sources for P. trituberculatus and 69.42% for M. japonicus in the PM system, and 60.82% and 57.60% in the PMS system. (4) The isotopic niche overlap between P. trituberculatus and M. japonicus was 5.69% in the PM system and 1.21% in the PMS system. These results suggested food competition between P. trituberculatus and M. japonicus , and S. constricta can reduce the competition and isotopic niche overlap, improve the contribution of food sources such as phytoplankton. Razor clams also serve to purify the water and improve the utilization of iced trash fish by filtering phytoplankton (51.10%), POM (32.25%), SOM (7.47%), and iced trash fish (9.18%). Thus, P. trituberculatus - M. japonicus - S. constricta is a healthy and sustainable culture model.

Chrysomutanin and related meroterpenoids from a DES mutant of the marine-derived fungus Penicillium chrysogenum S-3-25 - Hua Qiao; Shu-Hua Zhang; Yuan Dong; Yu Yang; Rui Xu; Bo Chen; Yi Wang; Tian-Jiao Zhu; Cheng-Bin Cui; Guo-Gang Zhang; Chang-Wei Li (Natural Product Research, 2022)

Ancient genomes reveal the genetic inheritance and recent introgression in Chinese indigenous pigs - Jia Wen; Zhuqing Zheng; Mian Gong; Dong Li; Songmei Hu; Yudong Cai; Yongdi Wang; Hojjat Asadollahpour Nanaei; Naifan Zhang; Taiyong Yu; Dawei Cai; Yu Jiang (Science China Life Sciences, 2022)

Arabidopsis CPR5 plays a role in regulating nucleocytoplasmic transport of mRNAs in ethylene signaling pathway - Jiacai Chen; Xinying Sui; Binran Ma; Yuetong Li; Na Li; Longfei Qiao; Yanchong Yu; Chun-Hai Dong (Plant Cell Reports, 2022)

Metabolomic profiling of brassinolide and abscisic acid in response to high-temperature stress - Jinhua Lv; Tianyu Dong; Yanping Zhang; Yu Ku; Ting Zheng; Haifeng Jia; Jinggui Fang (Plant Cell Reports, 2022)

Application of the hydrothermally treated oxytetracycline fermentation residue in agriculture: concentrations of antibiotic and resistance genes in soil and plant - Mohammed Awad; Zhe Tian; Ziming Han; Xiao Luan; Yu Zhang; Min Yang; Liping Dong (Journal of Soils and Sediments, 2022)

Whole-Exome Sequencing Identified a Novel Mutation in RNF216 in a Family with Gordon Holmes Syndrome - Ke-Liang Chen; He Wang; Gui-Xian Zhao; Lei Wei; Yu-Yuan Huang; Shi-Dong Chen; Jian Sun; Qiang Dong; Mei Cui; Jin-Tai Yu (Journal of Molecular Neuroscience, 2022)

The synergistic effects of TGF-β1 and RUNX2 on enamel mineralization through regulating ODAPH expression during the maturation stage - Yuan Tian; Haiyu Mu; Zhiheng Dong; Yu Wang; Yuguang Gao; Yan Gao; Li Zhang (Journal of Molecular Histology, 2022)

The impact of particulate matter 2.5 on the risk of hepatocellular carcinoma: a meta-analysis - Zeng-Hong Wu; Meng Zhao; Hong Yu; Hua-Dong Li (International Archives of Occupational and Environmental Health, 2022)

A genetic-based population PK/PD modeling of methadone in Chinese opiate dependence patients - Dong Guo; Zhirong Tan; Xiaoya Lou; Shan Shi; Yan Shu; Honghao Zhou; Li Yu; Hong Yang (European Journal of Clinical Pharmacology, 2022)

Production of sesquiterpene patchoulol in mitochondrion-engineered Saccharomyces cerevisiae - Xin-Yi Tao; Yang-Chen Lin; Feng-Qing Wang; Qing-Hai Liu; Yu-Shu Ma; Min Liu; Dong-Zhi Wei (Biotechnology Letters, 2022)

Abnormal functional connectivity of the salience network in insomnia - Yongxin Cheng; Ting Xue; Fang Dong; Yiting Hu; Mi Zhou; Xiaojian Li; Ruoyan Huang; Xiaoqi Lu; Kai Yuan; Dahua Yu (Brain Imaging and Behavior, 2022)

Petrogenesis and tectonic implications of Late Triassic dikes from the Suolun within the central Great Xing’an Range, NE China: constraints from geochronology and geochemistry - Yan Li; Hai-yin Xi; Feng-Jun Nie; Yao Zhang; Yue-ye Fan; Dong-yu Fang; Zhao-Bin Yan (Arabian Journal of Geosciences, 2022)

Effects of different stocking densities on the growth performance and antioxidant capacity of Chinese mitten crab (Eriocheir sinensis) in rice crab culture system - Xin Wang; Qi Yao; Xin-yu Lei; Dong-ming Zhang; Sen Wang; Ji-wu Wan; Hong-jian Liu; Yu-ke Chen; Yun-long Zhao; Gui-qin Wang; Qiu-ju Wang; Zhi-xin Guo (Aquaculture International, 2022)

Unexpected role of electron‐transfer hub in direct degradation of pollutants by exoelectrogenic bacteria - Ting‐Ting Zhu; Zhou‐Hua Cheng; Sheng‐Song Yu; Wen‐Wei Li; Dong‐Feng Liu; Han‐Qing Yu (Environmental Microbiology, 2022)
Summary Exoelectrogenic bacteria (EEB) are capable of anaerobic respiration with diverse extracellular electron acceptors including insoluble minerals, electrodes and flavins, but the detailed electron transfer pathways and reaction mechanisms remain elusive. Here, we discover that CymA, which is usually considered to solely serve as an inner‐membrane electron transfer hub in Shewanella oneidensis MR‐1 (a model EEB), might also function as a reductase for direct reducing diverse nitroaromatic compounds (e.g. 2,4‐dichloronitrobenzene) and azo dyes. Such a process can be accelerated by dosing anthraquinone‐2,6‐disulfonate. The CymA‐based reduction pathways in S . oneidensis MR‐1 for different contaminants could be functionally reconstructed and strengthened in Escherichia coli . The direct reduction of lowly polar contaminants by quinol oxidases like CymA homologues might be universal in diverse microbes. This work offers new insights into the pollutant reduction mechanisms of EEB and unveils a new function of CymA to act as a terminal reductase.

Hydroxytyrosol Attenuates High-Fat-Diet-Induced Oxidative Stress, Apoptosis and Inflammation of Blunt Snout Bream (Megalobrama amblycephala) through Its Regulation of Mitochondrial Homeostasis - Yanzou Dong; Tian Xia; Manhan Yu; Ling Wang; Kai Song; Chunxiao Zhang; Kangle Lu (Fishes, 2022)
The present study was conducted to investigate the effects of dietary hydroxytyrosol (HT) on oxidative stress, inflammation and mitochondrial homeostasis in blunt snout bream (Megalobrama amblycephala). Fish were fed a low-fat diet (LFD, 5% lipid), a high-fat diet (HFD, 15% lipid), an LFD supplementing 200 mg/kg HT, or an HFD supplementing 200 mg/kg HT. After 10-week feeding, significant reduction of growth was observed in fish fed HFD, compared with other groups. HFD caused oxidative stress and more apoptosis of hepatocytes, while HT addition resulted in significant decrease of ROS and MDA contents, and the apoptotic hepatocytes. Moreover, the expression of genes involving inflammation of HFD group were elevated. Supplementing HT to HFD can attenuate this. All the activities of complexes of mitochondria in the HFD group were decreased compared with those in the LFD group, while supplementing HT to HFD significantly increased complex I-III activities. Furthermore, HFD downregulated the expressions of Atg5 and NRF-1 which induced the failure of mitophagy and biogenesis, while, supplementing HT to HFD reversed these expressions involving mitochondrial autophagy and biogenesis. In summary, adding HT to HFD relieved oxidative stress, apoptosis and inflammation, likely due to its regulation of mitochondrial homeostasis.

Magnesium Isotopes in Pore Water of Active Methane Seeps of the South China Sea - Meng Jin; Dong Feng; Kangjun Huang; Shanggui Gong; Min Luo; Jörn Peckmann; Xudong Wang; Yu Hu; Duofu Chen (Frontiers in Marine Science, 2022)
The magnesium (Mg) isotopic composition of marine authigenic carbonates is considered as promising archive of ancient seawater geochemistry and paleoenvironments. Previous experimental and theoretical work has shown that Mg isotope fractionation during carbonate mineral formation is a function of mineralogy and precipitation rate. However, information on Mg isotope fractionation is limited for well-defined precipitation rates in natural settings. Here, we investigate pore waters from sediments of an area of active methane seepage in the South China Sea. Low δ 13 C values (< −48.3‰ VPDB) of dissolved inorganic carbon (DIC) near the sulfate-methane transition zone (SMTZ) indicate that sulfate-driven anaerobic oxidation of methane (SD-AOM) is the predominant biogeochemical process. Pore water composition of dissolved Mg, calcium (Ca), and strontium (Sr) agrees with aragonite as the dominant carbonate mineral at the site ROV1, and high Mg-calcite at sites ROV2 and ROV4. Calculated carbonate precipitation rates are 0.92 μmol cm −2 yr −1 for site ROV2 and 1.24 μmol cm −2 yr −1 for site ROV4; these estimates are similar to previous calculations for seeps from other areas. The pore water δ 26 Mg values (−0.88‰ to −0.71‰) obtained for the three study sites are similar to those of seawater, in accord with a minor effect of Rayleigh fractionation due to abundant supply of Mg from seawater and insignificant consumption of Mg during carbonate precipitation. The modeled Mg isotope fractionation (ϵ = −2.0‰ to −1.0‰ for core ROV2; ϵ = −1.3‰ to −0.3‰ for core ROV4) can be explained by kinetic isotope fractionation during carbonate precipitation. The calculated carbonate precipitation rates and the degree of fractionation of Mg isotopes support the notion that fractionation is small at high precipitation rates. However, the carbonate precipitation rates calculated for the studied seep environments are much smaller than those in laboratory experiments, documenting a discrepancy of isotopic fractionation between carbonate authigenesis in laboratory experiments and natural environments. These results, including the modeled precipitation rates, provide new constraints for Mg isotope fractionation in natural settings.

Observational angular analysis of Moon-based Earth observations - Jing Huang; Huadong Guo; Guang Liu; Hairong Wang; Yu Deng; Runbo Dong (International Journal of Remote Sensing, 2022)

Evacuation Strategy Considering Path Capacity and Risk Level for Cruise Ship - Yang Liu; Huajun Zhang; Yu Zhan; Kunxiang Deng; Liangzhi Dong (Journal of Marine Science and Engineering, 2022)
Cruise ships are large and complex, and it is difficult to manually make a plan to evacuate people to safe areas in a short time. Evacuation time and personnel safety are both important for emergency evacuation. This paper proposes an evacuation strategy that considers the path capacity and risk level to guide evacuees in fire; it not only ensures the safety of people on dangerous paths but also reduces road congestion to shorten evacuation time. High crowd density means slow moving speed, an exponential function including straight path and stairs speed characteristics is proposed to illustrate the relationship between crowd density and moving speed. Path capacity constraints are used to avoid the congestion caused by the evacuees in a panic. In order to evacuate the evacuees in the risk areas as soon as possible, this paper divides the path into three risk levels according to carbon monoxide concentration, visibility, and temperature along the paths. The people on the higher-risk paths are given higher priority to enter evacuation paths than those on lower risk. The priority strategy evacuates the people on risk paths to safe areas in less time. This paper models the evacuation network topology of a cruise ship and simulates the evacuation process of some situations that have different numbers of evacuees and path capacity constraints. The evacuation strategies and simulation results are guidelines for the crews to guide the people to evacuate to safe areas when there is a fire accident on the cruise ship.

MeSPL9 attenuates drought resistance by regulating JA signaling and protectant metabolite contents in cassava - Shuxia Li; Zhihao Cheng; Zhibo Li; Shiman Dong; Xiaoling Yu; Pingjuan Zhao; Wenbin Liao; Xiang Yu; Ming Peng (Theoretical and Applied Genetics, 2022)

Neural circuit control of innate behaviors - Wei Xiao; Zhuo-Lei Jiao; Esra Senol; Jiwei Yao; Miao Zhao; Zheng-Dong Zhao; Xiaowei Chen; Peng Cao; Yu Fu; Zhihua Gao; Wei L. Shen; Xiao-Hong Xu (Science China Life Sciences, 2022)

Screening and identification of HLA-A2-restricted neoepitopes for immunotherapy of non-microsatellite instability-high colorectal cancer - Ranran Shi; Yubing Li; Ling Ran; Yu Dong; Xiuman Zhou; Jingwen Tang; Lu Han; Mingshuang Wang; Liwei Pang; Yuanming Qi; Yahong Wu; Yanfeng Gao (Science China Life Sciences, 2022)

Functional characterization of tyrosine decarboxylase genes that contribute to acteoside biosynthesis in Rehmannia glutinosa - Yan Hui Yang; Mu Rong Yang; Jian Yu Zhu; Ke Wei Dong; Yan Jie Yi; Rui Fang Li; Lei Zeng; Chang Fu Zhang (Planta, 2022)

Redescription of the Sanqiaspidae (Galeaspida) from the Lower Devonian of South China and its biostratigraphic significance - Zhi-Kun Gai; Wen-Yu Jiang; Wen-Jin Zhao; Qiang Li; Xiao-Dong Shi; Min Zhu (Palaeobiodiversity and Palaeoenvironments, 2022)

Polysaccharide Krestin Prevents Alzheimer’s Disease-type Pathology and Cognitive Deficits by Enhancing Monocyte Amyloid-β Processing - Si-Han Chen; Chen-Yang He; Ying-Ying Shen; Gui-Hua Zeng; Ding-Yuan Tian; Yuan Cheng; Man-Yu Xu; Dong-Yu Fan; Cheng-Rong Tan; An-Yu Shi; Xian-Le Bu; Yan-Jiang Wang (Neuroscience Bulletin, 2022)

Multi-omics analysis reveals metabolism of okadaic acid in gut lumen of rat - Yang Liu; Yang Lu; Yu-Hu Jiao; Da-Wei Li; Hong-Ye Li; Wei-Dong Yang (Archives of Toxicology, 2022)

Propagation and Separation of Downslope Gravity Currents over Rigid and Emergent Vegetation Patches in Linearly Stratified Environments - Ying-Tien Lin; Yi-Qi Ye; Dong-Rui Han; Yu-Jia Chiu (Journal of Marine Science and Engineering, 2022)
Large eddy simulation (combined with the mixture model) and laboratory experiment were used to investigate the impact of emergent and rigid vegetation on the dynamics of downslope gravity currents in stratified environments. The reliability of the numerical model was assessed with the corresponding laboratory measurements. The results show that the vegetation cylinders lead to severe lateral non-uniformity of the current front, causing more evident lobe and cleft structures. In stratified environments, the smaller driving force leads to less propagating velocity until the current separates from the slope. The transition point (from acceleration to deceleration phases) of current velocity appears earlier as the vegetation becomes denser. The peak value of the bulk entrainment coefficient Ebuik is inversely proportional to the vegetation density, while the final converged value of Ebuik is proportional to the vegetation density. Vegetation patches make the degree of fluctuation of the instantaneous entrainment coefficient Einst more intense, and even negative values appear locally, indicating that the gravity current is detrained into the ambient fluid. The velocity profiles of gravity current develop multi-peak patterns in stratified environments due to fingering intrusive patterns. Our analysis reveals that as the vegetation density increases, the generated wakes behind vegetation cylinders increase local entrainment and mixing, causing the density of current flow from vegetation to decrease and reach the neutral buoyancy layer of ambient fluids earlier, finally leading to a smaller separation depth.

Transition in tectonic regime from the Paleo-Asian Ocean to Paleo-Pacific Ocean: constraints from the Jurassic adakitic and I-type granites, and calc-alkaline diorites at the northern margin of the North China Craton - Yan Jing; Wen-Chun Ge; Yu Dong; Hao Yang; Zheng Ji; Jun-Hui Bi; Hong-Ying Zhou; De-He Xing (International Geology Review, 2022)

Three new terpenoids from Chonemorpha megacalyx - Fang-Yu Yuan; Xiao-Ling Wang; Shu-Qi Wang; Tao Shen; Dong-Mei Ren; Hong-Xiang Lou; Xiao-Ning Wang (Natural Product Research, 2022)

Study on Runoff Control Effect of Different Drainage Schemes in Sponge Airport - Jing Peng; Lei Yu; Xiang Zhong; Tiansong Dong (Water Resources Management, 2022)

Response of soil respiration to water and nitrogen addition and its influencing factors: a four-year field experiment in a temperate steppe - ZhaoLin Li; Qin Peng; YunShe Dong; YunLong He; ZhongQing Yan; Yu Guo; Shuqi Qin; Yuchun Qi (Plant and Soil, 2022)

Oxygen Metabolism-induced Stress Response Underlies Heart–brain Interaction Governing Human Consciousness-breaking and Attention - Xiao-Juan Xue; Rui Su; Ze-Feng Li; Xiao-Ou Bu; Peng Dang; Si-Fang Yu; Zhi-Xin Wang; Dong-Mei Chen; Tong-Ao Zeng; Ming Liu; Hai-Lin Ma; De-Long Zhang (Neuroscience Bulletin, 2022)

Anshen-Buxin-Liuwei pill, a Mongolian medicinal formula could alleviate cardiomyocyte hypoxia/reoxygenation injury via mitochondrion pathway - Yu-Jia Huang; Hai‑Ying Tong; Xian‑Ju Huang; Xin-Cai Xiao; Yue Dong; Muhammad Sarfaraz Iqbal (Molecular Biology Reports, 2022)

Lentinan triggers oxidative stress-mediated anti-inflammatory responses in lung cancer cells - Mo Li; Xin Du; Zheng Yuan; Mengzhi Cheng; Penghua Dong; Yu Bai (Molecular and Cellular Biochemistry, 2022)

Ginkgolide B inactivates the NLRP3 inflammasome by promoting autophagic degradation to improve learning and memory impairment in Alzheimer’s disease - Li Shao; Chen Dong; Deqin Geng; Qing He; Yu Shi (Metabolic Brain Disease, 2022)

Caveolin-1 knockout mice have altered serum N-glycan profile and sialyltransferase tissue expression - Xixi Chen; Liping Wang; Yinshuang Wu; Hongshuo Zhang; Weijie Dong; Xiao Yu; Chuncui Huang; Yan Li; Shujing Wang; Jianing Zhang (Journal of Physiology and Biochemistry, 2022)

Association between non-optimal temperature and hospitalizations for gout in Anqing, China: a time-series analysis - Yi-Sheng He; Gui-Hong Wang; Zheng-Dong Wu; Napoleon Bellua Sam; Yue Chen; Jin-Hui Tao; Xin-Yu Fang; Zhiwei Xu; Hai-Feng Pan (Environmental Science and Pollution Research, 2022)

A Simple Protocol for Thallus Culture-Based Genetic Transformation of the Liverwort Marchantia polymorpha - Dong Hye Seo; Sojung Kim; Hyeon Ji Seo; Seung Eun Lee; Cheol Jin Lim; Hee Woong Yang; Li Hua Cui; Min Yong Ahn; Seong Gwan Yu; Na Hyun Cho; So Young Park; Ji Hee Lee; et al. (Journal of Plant Biology, 2022)

Characterization of BRASSINOSTEROID F-BOX Proteins BRFPs that Regulate BRASSINOSTEROID-INSENSITIVE 2 Kinase - Yu Jeong Jeong; June Seung Lee; Dong-Gwan Kim (Journal of Plant Biology, 2022)

Effect of freeze—thaw cycle on hydraulic conductivity of compacted clayey soil - Lei Guo; Qi-hao Yu; Na Yin; Dong-ming Zhang; Deng-ping Zhang; Xiu-ling Ren; Yan-hui You; Zhen-yu Zhang; Hui Bing; Shi-jie Chen (Journal of Mountain Science, 2022)

Optimal array layout of cylindrical baffles to reduce energy of rock avalanche - Yu-zhang Bi; Dong-po Wang; Xian-lei Fu; Yi-xiong Lin; Xin-po Sun; Zhe-yuan Jiang (Journal of Mountain Science, 2022)

Geochronology and Geochemistry of Late Devonian I- and A-Type Granites from the Xing’an Block, NE China: Implications for Slab Break-off during Subduction of the Hegenshan-Heihe Ocean - Zheng Ji; Wenchun Ge; Hao Yang; Yanlong Zhang; Yu Dong; Junhui Bi; Xiwen Liu (Journal of Earth Science, 2022)

A galacturonan from Dioscorea opposita Thunb. regulates fecal and impairs IL-1 and IL-6 expression in diarrhea mice - Hao-Yu Pan; Chun-Qian Zhang; Xiu-Qi Zhang; Hui Zeng; Chun-hong Dong; Xia Chen; Kan Ding (Glycoconjugate Journal, 2022)

Reoxygenation of the Hypoxia in the East China Sea: A Ventilation Opening for Marine Life - Chung-Chi Chen; Dong S. Ko; Gwo-Ching Gong; Chun-Chi Lien; Wen-Chen Chou; Hung-Jen Lee; Fuh-Kwo Shiah; Yu-Sin Wita Huang (Frontiers in Marine Science, 2022)
Hypoxia and upwelling co-occur in the summer, and well-mixed water typically reaches the subsurface in the East China Sea (ECS), especially off the Changjiang River estuary. The impact of upwelling on hypoxia and, therefore, on the ecosystem in the ECS is not known. This study demonstrates both positive and negative effects of upwelling on hypoxia and its impact on the ecosystem. With upwelling, the spatial extent of hypoxic water increases with a lower pH but waters with high regenerated nutrients and fugacity of CO 2 ( f CO 2 ), which are normally confined to the near-bottom, are found just up to 5–10 m below the surface. This upwelled high nutrient water can enhance phytoplankton growth in this region. On one occasion in August 2014, upwelling reached to the surface and lasted for 3 weeks, with the area of coverage ranging from 326.8 to 24,368.0 km 2 . During this event, the water was mixed thoroughly throughout the water column, with high concentrations of nutrients, chlorophyll a , and slightly undersaturated dissolved oxygen but saturated f CO 2 , alongside a normal pH. This event may have served as an important pathway from the ocean to the atmosphere for the regenerated CO 2 . It also provided a productive and suitable environment for marine life and ventilation to alleviate low-oxygen stress in this hypoxic but upwelling region in the ECS.

Two new benzoic acid derivatives from endophytic fungus Aspergillus versicolor - Yanqing Ye; Yanjun Chen; Yuting Hou; Hongmei Yu; Lijun Zhu; Yanqi Sun; Min Zhou; Yijian Chen; Miao Dong (Natural Product Research, 2022)

YAP regulates porcine skin-derived stem cells self-renewal partly by repressing Wnt/β-catenin signaling pathway - Hong-Chen Yan; Yu Sun; Ming-Yu Zhang; Shu-Er Zhang; Jia-Dong Sun; Paul W. Dyce; Francesca Gioia Klinger; Massimo De Felici; Wei Shen; Shun-Feng Cheng (Histochemistry and Cell Biology, 2022)

Sustainable development of China's regions from the perspective of ecological welfare performance: analysis based on GM(1,1) and the malmquist index - Yu Song; Dong Mei (Environment, Development and Sustainability, 2022)

Paracoccus shandongensis sp. nov., Isolated from Activated Sludge - Xiao-Fan Gong; Fang Wang; Dong Meng; Yu-Ling Liu; Peng-Fei Gu; Xiang-Yu Fan; Zhao-Song Huang; Zong-Jun Du; Qiang Li (Current Microbiology, 2022)

Alteribacter salitolerans sp. nov., isolated from a saline-alkaline soil - Shuang Wang; Lei Sun; Manik Prabhu Narsing Rao; Guo-Hong Liu; Pin-Jiao Jin; Zhou-Yan Dong; Zheng-Han Lian; Xiao-Yu Hao; Ming-Yi Zhang; Wen-Jun Li (Archives of Microbiology, 2022)

Mesorhizobium xinjiangense sp. nov., isolated from rhizosphere soil of Alhagi sparsifolia - Dong Meng; Yu-Ling Liu; Jun-Jie Zhang; Peng-Fei Gu; Xiang-Yu Fan; Zhao-Song Huang; Yan Ji; Heng Meng; Zong-Jun Du; Wei-Min Li; Qiang Li (Archives of Microbiology, 2022)

Laser ablation inductively coupled plasma mass spectrometry analysis of Chinese lead-barium glass: combining multivariate kernel density estimation and maximum mean discrepancy to reinterpret the raw glass used for producing lead-barium glass - Qian Ma; Rui Wen; Yifan Yu; Long Wang; Man Li; Luwu Cai; Li Ping; Zhiqiang Zhao; Dong Wang; Xiang Wang; Ruoyu Shi; A. Mark Pollard (Archaeological and Anthropological Sciences, 2022)

Ocean Response to a Climate Change Heat-Flux Perturbation in an Ocean Model and Its Corresponding Coupled Model - Jiangbo Jin; Xiao Dong; Juanxiong He; Yi Yu; Hailong Liu; Minghua Zhang; Qingcun Zeng; He Zhang; Xin Gao; Guangqing Zhou; Yaqi Wang (Advances in Atmospheric Sciences, 2022)

Benzofuran derivatives with nerve growth factor-potentiating activity from Phellinus ribis - Mei-Yue Dong; Yan Zhang; Hai-Qiang Jiang; Wen-Jing Ren; Ling-Chuan Xu; Yong-Qing Zhang; Yu-Hong Liu (Natural Product Research, 2021)

Two new troponoides with anti-inflammatory activity from the stems of Juniperus formosana Hayata - Dong Zheng; Jian-Yu Zhang; Wen-Hao Fu; Shun-Zhi Liu; Su-Zhi Xie; Zheng Wang; Ying-Kun Qiu (Natural Product Research, 2021)

A Preclinical Study of Human Embryonic Stem Cell-Derived Mesenchymal Stem Cells for Treating Detrusor Underactivity by Chronic Bladder Ischemia - Hwan Yeul Yu; Jung Hyun Shin; HongDuck Yun; Chae-Min Ryu; Seungun Lee; Jinbeom Heo; Jisun Lim; Juhyun Park; Ki-Sung Hong; Hyung-Min Chung; Dong-Myung Shin; Myung-Soo Choo (Stem Cell Reviews and Reports, 2021)
Background The therapeutic effects of human embryonic stem cell-derived multipotent mesenchymal stem cells (M-MSCs) were evaluated for detrusor underactivity (DUA) in a rat model with atherosclerosis-induced chronic bladder ischemia (CBI) and associated mechanisms. Methods Sixteen-week-old male Sprague–Dawley rats were divided into five groups ( n = 10). The DUA groups underwent 30 bilateral repetitions of endothelial injury to the iliac arteries to induce CBI, while the sham control group underwent a sham operation. All rats used in this study received a 1.25% cholesterol diet for 8 weeks. M-MSCs at a density of 2.5, 5.0, or 10.0 × 10 5 cells (250 K, 500 K, or 1000 K; K = a thousand) were injected directly into the bladder 7 weeks post-injury, while the sham and DUA group were treated only with vehicle (phosphate buffer solution). One week after M-MSC injection, awake cystometry was performed on the rats. Then, the bladders were harvested, studied in an organ bath, and prepared for histological and gene expression analyses. Results CBI by iliac artery injury reproduced voiding defects characteristic of DUA with decreased micturition pressure, increased micturition interval, and a larger residual volume. The pathological DUA properties were improved by M-MSC treatment in a dose-dependent manner, with the 1000 K group producing the best efficacy. Histological analysis revealed that M-MSC therapy reduced CBI-induced injuries including bladder fibrosis, muscular loss, and apoptosis. Transplanted M-MSCs mainly engrafted as vimentin and NG2 positive pericytes rather than myocytes, leading to increased angiogenesis in the CBI bladder. Transcriptomes of the CBI-injured bladders were characterized by the complement system, inflammatory, and ion transport-related pathways, which were restored by M-MSC therapy. Conclusions Single injection of M-MSCs directly into the bladder of a CBI-induced DUA rat model improved voiding profiles and repaired the bladder muscle atrophy in a dose-dependent manner. Graphical abstract

Recent advances in tissue stem cells - Xin Fu; Qiang He; Yu Tao; Mengdi Wang; Wei Wang; Yalong Wang; Qing Cissy Yu; Fang Zhang; Xiaoyu Zhang; Ye-Guang Chen; Dong Gao; Ping Hu; et al. (Science China Life Sciences, 2021)

The regulation of DKGA2ox1 and miR171f_3 in scion dwarfing with Diospyros kaki Thunb. cv. ‘Nan-tong-xiao-fang-shi’ as interstocks - Yuhan Dong; Xialin Ye; Lifang Cao; Xinyi Yu; Shenchun Qu (Planta, 2021)

In Silico Analysis of Potential Outer Membrane Beta-Barrel Proteins in Aeromonas hydrophila Pangenome - Furqan Awan; Muhammad Muddassir Ali; Yuhao Dong; Yong Yu; Zhenling Zeng; Yongjie Liu (International Journal of Peptide Research and Therapeutics, 2021)

Source analysis and health risk assessment of groundwater pollution based on multivariate statistical techniques in Kashgar Delta Area, Xinjiang, China - Dong Yu; Jinlong Zhou; Ailihamu Aikelamu; Wei Fan; Yanyan Zeng; Jie Zhang (Environmental Monitoring and Assessment, 2021)

Astaxanthin Ameliorates Blood Pressure in Salt-Induced Prehypertensive Rats Through ROS/MAPK/NF-κB Pathways in the Hypothalamic Paraventricular Nucleus - Hong-Li Gao; Xiao-Jing Yu; Yan Zhang; Chen-Long Wang; Yi-Ming Lei; Jia-Yue Yu; Dong-Miao Zong; Kai-Li Liu; Dong-Dong Zhang; Ying Li; Hua Tian; Nian-Ping Zhang; et al. (Cardiovascular Toxicology, 2021)

Biological synthesis of nicotinamide mononucleotide - Qi Shen; Shi-Jia Zhang; Yu-Zhen Xue; Feng Peng; Dong-Yuan Cheng; Ya-Ping Xue; Yu-Guo Zheng (Biotechnology Letters, 2021)

Analysis of expression characteristics of soybean leaf and root tissue-specific promoters in Arabidopsis and soybean - Hongwei Xun; Xue Zhang; Jiamiao Yu; Jinsong Pang; Shucai Wang; Bao Liu; Yingshan Dong; Lili Jiang; Dongquan Guo (Transgenic Research, 2021)

Omi inhibition ameliorates neuron apoptosis and neurological deficit after subarachnoid hemorrhage in rats - Yuanfeng Du; Dingbo Yang; Xiaoqiao Dong; Quan Du; Ding Wang; Yongfeng Shen; Wenhua Yu (Genes & Genomics, 2021)
Background Subarachnoid hemorrhage (SAH) is a severe neurological emergency, resulting in cognitive impairments and threatening human's health. Currently, SAH has no effective treatment. It is urgent to search for an effective therapy for SAH. Objective To explore the expression of Omi protein after subarachnoid hemorrhage in rats. Methods SAH rat model was established by injecting blood into the prechiasmatic cistern. Neurological deficit was assessed by detecting neurological deficit scores and brain tissue water contents. Apoptotic cells were evaluated by TUNEL staining and IHC staining. Omi and Cleaved caspase 3 expressions in nerve cells were determined by double staining using IF. Apoptosis-related proteins were measured by Western blotting assay. Results SAH rat model was successfully established, showing more apoptotic cells and high neurological deficit scores in SAH rat. In SAH rat model, Omi expression in nerve cells was elevated and the upregulation of Omi mainly occurred in cytoplasm, accompanied by the degradation of XIAP and the increased cleaved caspase 3/9 and cleaved PARP. Once treated with UCF-101, a specific inhibitor of Omi, the increased cell apoptosis, left/right brain moisture contents and neurological deficits were notably reversed in SAH rat brain. Of note, SAH-induced the increases of apoptosis-related protein in nerve cells were also rescued by the administration of UCF-101. Conclusions UCF-101-mediated Omi inhibition decreased the degradation of XIAP and subsequently inhibited the activation of apoptosis-related proteins, decreased nerve cell apoptosis, leading to the improvement on early brain injury in SAH rat. UCF-101-based Omi inhibition may be used to treat SAH with great potential application.

A novel regQTL-SNP and the risk of lung cancer: a multi-dimensional study - Yuhui Yu; Liping Mao; Zhounan Cheng; Xiaoqi Zhu; Jiahua Cui; Xiaoyu Fu; Jingwen Cheng; Yan Zhou; Anni Qiu; Yang Dong; Xun Zhuang; Yihua Lu; et al. (Archives of Toxicology, 2021)

Truffle species strongly shape their surrounding soil mycobiota in a Pinus armandii forest - Dong Liu; Mariana Herrera; Peng Zhang; Xinhua He; Jesús Perez-Moreno; Caspar C. C. Chater; Fuqiang Yu (Archives of Microbiology, 2021)

Effects of replacing fishmeal with soybean protein concentrate (SPC) on growth, blood biochemical indexes, non-specific immune enzyme activity, and nutrient apparent digestibility for juvenile Litopenaeus vannamei - Zhan-Hao Zhu; Qi-hui Yang; Bei-ping Tan; Xiao-Qiu Zhou; Xiao-hui Dong; Shu-yan Chi; Hong-yu Liu; Shuang Zhang (Aquaculture International, 2021)

Controlling pathogenic risks of water treatment biotechnologies at the source by genetic editing means - Jie Wu; Dong‐Feng Liu; Hui‐Hui Li; Di Min; Jia‐Qi Liu; Peng Xu; Wen‐Wei Li; Han‐Qing Yu; Yong‐Guan Zhu (Environmental Microbiology, 2021)
Summary Antimicrobial‐resistant pathogens in the environment and wastewater treatment systems, many of which are also important pollutant degraders and are difficult to control by traditional disinfection approaches, have become an unprecedented treat to ecological security and human health. Here, we propose the adoption of genetic editing techniques as a highly targeted, efficient and simple tool to control the risks of environmental pathogens at the source. An ‘all‐in‐one’ plasmid system was constructed in Aeromonas hydrophila to accurately identify and selectively inactivate multiple key virulence factor genes and antibiotic resistance genes via base editing, enabling significantly suppressed bacterial virulence and resistance without impairing their normal phenotype and pollutant‐degradation functions. Its safe application for bioaugmented treatment of synthetic textile wastewater was also demonstrated. This genetic‐editing technique may offer a promising solution to control the health risks of environmental microorganisms via targeted gene inactivation, thereby facilitating safer application of water treatment biotechnologies.

Functional Trait Responses of Macrobenthos to Anthropogenic Pressure in Three Temperate Intertidal Communities - Jian-Yu Dong; Linlin Zhao; Xiaolong Yang; Xin Sun; Xiumei Zhang (Frontiers in Marine Science, 2021)
With the increasing impact of human activities on marine ecosystems, there is a growing need to assess how the components of marine ecosystems (e.g., macrobenthos) respond to these anthropogenic pressures. In this work, the trait-based approach was used to assess the effects of anthropogenic pressures represented by the area of land-based aquaculture pond (Pond Area) and heavy metals on the macrobenthic communities in three intertidal zones[Aoshan Bay (AO), Wenquan River and Daren River (RW), and Xiaodao Bay (XD)] of Laoshan Bay, Shandong Peninsula, China. Compared with RW and XD, AO was under more pressure in terms of the average concentrations of heavy metals and total organic carbon (TOC) in sediments and also in the Pond Area. Fuzzy correspondence analysis (FCA) showed that there were significant differences in the composition of functional traits among the three regions (PERMANOVA; p < 0.05). In the highly polluted area, macrobenthic communities exhibited a combination of traits, such as relatively short life span, weak mobility, feeding on deposits, and more tolerant to organic matter, whereas in a less polluted area, they exhibited a combination of traits, such as relatively long life span, relatively high mobility, and more sensitivity to organic matter. The RDA results showed that the distribution of the trait modalities was significantly affected by heavy metals (Hg and Cd), TOC, Pond Area, and sampled location. Variation partitioning analysis (VPA) indicated that the shared influence of sediment-related pollution factors and Pond Area contributed most to the variance of the functional traits, which implied that human activities directly and/or indirectly lead to changes in functional traits of macrobenthic communities in the intertidal zones.

Three new diterpenoids from Euphorbia peplus - Yan-Ni Chen; Qing-Yun Lu; Dong-Mei Li; Ying-Yao Li; Xue-Xue Pu; Bo-Ting Li; Xiao-Han Tang; Hong-Yu Tang; Shuai Liu; Lei Yang; Yu Zhang; Ying-Tong Di; et al. (Natural Product Research, 2021)

An Ensemble Hybrid Forecasting Model for Annual Runoff Based on Sample Entropy, Secondary Decomposition, and Long Short-Term Memory Neural Network - Wen-chuan Wang; Yu-jin Du; Kwok-wing Chau; Dong-mei Xu; Chang-jun Liu; Qiang Ma (Water Resources Management, 2021)

Multi-model streamflow prediction using conditional bias-penalized multiple linear regression - Ali Jozaghi; Haojing Shen; Mohammadvaghef Ghazvinian; Dong-Jun Seo; Yu Zhang; Edwin Welles; Seann Reed (Stochastic Environmental Research and Risk Assessment, 2021)

The Beneficial Role of Exercise on Treating Alzheimer’s Disease by Inhibiting β-Amyloid Peptide - Zi-Xuan Tan; Fang Dong; Lin-Yu Wu; Ya-Shuo Feng; Feng Zhang (Molecular Neurobiology, 2021)

Emerging Benefits: Pathophysiological Functions and Target Drugs of the Sigma-1 Receptor in Neurodegenerative Diseases - Ning-hua Wu; Yu Ye; Bin-bin Wan; Yuan-dong Yu; Chao Liu; Qing-jie Chen (Molecular Neurobiology, 2021)

Evaluation of the antifungal activity of Lysurus mokusin extract against Pestalotiopsis neglecta and GC–MS analysis of the active components - Lian-Nan Lin; Jing Yang; Guo-Cai Zhang; Xiao-Bo Zhang; Ting-Yu Wang; De-Dong Wu (Journal of Plant Pathology, 2021)

Temporal trends and source apportionment of water pollution in Honghu Lake, China - Shuai Chen; Simeng Wang; Yanxi Yu; Mingjun Dong; Yanqiang Li (Environmental Science and Pollution Research, 2021)

Assessing vegetation community distribution characteristics and succession stages in mountainous areas hosting coming Winter Olympics Games - Heng-shuo Zhang; Tong-gang Zha; Yang Yu; Xiao-dong Ji; Rodrigo-Comino Jesús (Journal of Mountain Science, 2021)

Diagnostic evaluation of qRT-PCR-based kit and dPCR-based kit for COVID-19 - Cherl-Joon Lee; Wonseok Shin; Seyoung Mun; Minjae Yu; Young-Bong Choi; Dong Hee Kim; Kyudong Han (Genes & Genomics, 2021)

A strain of highly pathogenic porcine reproductive and respiratory syndrome virus: genomic characterization, pathogenicity, and construction of an infectious full-length cDNA clone - Shuangyun Wang; Yanling Liu; Linyang Yu; Tairun Liang; Pengfei Zhang; Jianguo Dong; Leyi Zhang; Pengshuai Liang; Lei Wang; Zheng Xu; Changxu Song (Archives of Virology, 2021)

Understanding the Yanshan volcano eruption in the Chaihe–Arxan volcanic field, northeastern China - Xiao-ge Cui; Jian-dong Xu; Hong-mei Yu; Bo Zhao; Wen-jian Yang (Arabian Journal of Geosciences, 2021)

Induced production of a new polyketide in Penicillium sp. HS-11 by chemical epigenetic manipulation - You-Min Ying; Ling Li; Hang-Fei Yu; Yi-Lian Xu; Lu Huang; Wei Mao; Cui-Ping Tong; Zhi-Dong Zhang; Zha-Jun Zhan; Yun Zhang (Natural Product Research, 2021)

Global spatio-temporal sampling characteristics of Moon-based Earth observations - Yu Deng; Huadong Guo; Guang Liu; Jing Huang; Runbo Dong; Hairong Wang; Hanlin Ye (International Journal of Remote Sensing, 2021)

Assessment of the Carrying Capacity of Integrated Pond Aquaculture of Portunus trituberculatus at the Ecosystem Level - Shipeng Dong; Fang Wang; Dongxu Zhang; Liye Yu; Weijia Pu; Xian Xu; Yicheng Xie (Frontiers in Marine Science, 2021)
In recent years, integrated pond aquaculture under controlled management has been crucial in improving the supply of aquatic products and ensuring food security. This study constructed two trophic models of integrated pond aquaculture ecosystems of Portunus trituberculatus – Penaeus japonicus (PP) and P. trituberculatus – P. japonicus – Sinonovacula constricta (PPS) using Ecopath with Ecosim software. The energy flows, ecosystem properties, and carrying capacities of the two ecosystems were analyzed and evaluated. The results showed that the ecotrophic efficiency values in the PP and PPS ecosystems were 0.962 and 0.954 for P. trituberculatus and P. japonicus and 0.952 for S. constricta . The effective trophic levels of P. trituberculatus and P. japonicus were 2.065 and 2.027 in the PP system, and those of P. trituberculatus , P. japonicus , and S. constricta were 2.057, 2.018, and 2.010 in the PPS system. The primary productivities of the PP and PPS ecosystems were 2623.79 and 2781.48 g/m 2 /240 days, with 2.13 and 37.83% of the energy flowing to trophic level II and 97.87 and 62.17% flowing to the detritus, respectively. The total energy of the detritus group was 2900.89 and 2372.98 g/m 2 /240 days, with 931.02 and 1505.35 g/m 2 /240 days flowing to trophic level II, respectively. The total primary production/total respiration ratio of the PPS ecosystem (1.632) was lower than that of the PP ecosystem (4.824), indicating that the former had a greater degree of exploitation. At the current feeding level, the carrying capacities of P. trituberculatus and P. japonicus were 65.15 and 47.62 g/m 2 in the PP ecosystem, and those of P. trituberculatus , P. japonicus , and S. constricta were 64.96, 48.06, and 100.79 g/m 2 in the PPS ecosystem, respectively. At adequate feeding levels, the carrying capacities of P. trituberculatus and P. japonicus were 83.76 and 48.52 g/m 2 in the PP ecosystem and 81.82 and 53.44 g/m 2 in the PPS ecosystem. The ecotrophic efficiency values and energy flow parameters of the two integrated pond aquaculture ecosystems indicated that S. constricta was a suitable collocation culture species for P. trituberculatus and P. japonicus , and there is room for further improvement in yields of this integrated aquaculture ecosystem.

Evaluation of grain size and content of nonplastic fines on undrained behavior of sandy soils - Ling-Yu Xu; Fei Cai; Jing-Zhe Zhang; Dong-Dong Pan; Qi Wu; Guo-Xing Chen (Marine Georesources & Geotechnology, 2021)

Implantation of Bone Marrow Mesenchymal Stem Cells into Small Intestinal Submucosa Improves Bile Duct Injury in Rabbits - Ying Li; Piao Wang; Xiao-dong Hu; Jing-da Zeng; Cheng Fang; Yu Gan; Fang-yi Peng; Xiao-li Yang; De Luo; Bo Li; Song Su (Tissue Engineering and Regenerative Medicine, 2021)

Development and application of the Faba_bean_130K targeted next-generation sequencing SNP genotyping platform based on transcriptome sequencing - Chenyu Wang; Rong Liu; Yujiao Liu; Wanwei Hou; Xuejun Wang; Yamei Miao; Yuhua He; Yu Ma; Guan Li; Dong Wang; Yishan Ji; Hongyan Zhang; et al. (Theoretical and Applied Genetics, 2021)

iTRAQ-based proteomic analysis provides insights into the molecular mechanisms of rice formyl tetrahydrofolate deformylase in salt response - Erhui Xiong; Chen Zhang; Chenxi Ye; Yaohuang Jiang; Yanli Zhang; Fei Chen; Guojun Dong; Dali Zeng; Yanchun Yu; Limin Wu (Planta, 2021)

Study on synthesis and anticancer activity of 17beta-estradiol-phenol/aniline nitrogen mustard derivatives - Yu-dong Yin; Jing-jing Liu; Wen-fei Liao; Xian-kun Guo; Li-shan Zhang; Wei-bin Mo; Ke-guang Cheng (Medicinal Chemistry Research, 2021)

Elabela prevents angiotensin II-induced apoptosis and inflammation in rat aortic adventitial fibroblasts via the activation of FGF21–ACE2 signaling - Juan-Juan Song; Mei Yang; Ying Liu; Jia-Wei Song; Xiao-Yan Liu; Ran Miao; Zhen-Zhou Zhang; Yu Liu; Yi-Fan Fan; Qian Zhang; Ying Dong; Xin-Chun Yang; et al. (Journal of Molecular Histology, 2021)

Influences and mechanisms of nanoparticles on pentachloronitrobenzene accumulation by earthworms - Ming Li; Guanghui Xu; Na Guo; Na Zheng; Weihua Dong; Xiao Li; Yong Yu (Environmental Science and Pollution Research, 2021)

Effect of mangrove restoration on sediment properties and bacterial community - Xiao-Xia Ma; Zhao-Yu Jiang; Peng Wu; Yong-Fei Wang; Hao Cheng; You-Shao Wang; Ji-Dong Gu (Ecotoxicology, 2021)

Collinsella acetigenes sp. nov., an Anaerobic Actinobacterium Isolated from Human Feces, and Emended Description of the Genus Collinsella and Collinsella aerofaciens - Kook-Il Han; Ji-Sun Kim; Mi Kyung Eom; Keun Chul Lee; Min Kuk Suh; Han Sol Kim; Seung-Hwan Park; Ju Huck Lee; Se Won Kang; Jam-Eon Park; Byeong Seob Oh; Seoung Woo Ryu; et al. (Current Microbiology, 2021)

Sandaracinobacteroides hominis gen. nov., sp. nov., isolated from human skin - Ping-Hua Qu; Hai-Min Luo; Jun-Hui Feng; Song Li; Cha Chen; Lei Dong; Yu-Zhen Ming; Wen-Jun Li; Ying Lin (Archives of Microbiology, 2021)

Polycyclic Aromatic Hydrocarbons (PAHs) in Indoor Dust Across China: Occurrence, Sources and Cancer Risk Assessment - Baolin Liu; Fei Huang; Yong Yu; Weihua Dong (Archives of Environmental Contamination and Toxicology, 2021)

Eddy diffusivity and coherent mesoscale eddy analysis in the Southern Ocean - Wenjin Sun; Jingsong Yang; Wei Tan; Yu Liu; Baojun Zhao; Yijun He; Changming Dong (Acta Oceanologica Sinica, 2021)

Three-dimensional properties of mesoscale cyclonic warm-core and anticyclonic cold-core eddies in the South China Sea - Wenjin Sun; Yu Liu; Gengxin Chen; Wei Tan; Xiayan Lin; Yuping Guan; Changming Dong (Acta Oceanologica Sinica, 2021)

High-resolution genome-wide association study and genomic prediction for disease resistance and cold tolerance in wheat - Yunlong Pang; Yuye Wu; Chunxia Liu; Wenhui Li; Paul St. Amand; Amy Bernardo; Danfeng Wang; Lei Dong; Xiufang Yuan; Huirui Zhang; Meng Zhao; Linzhi Li; et al. (Theoretical and Applied Genetics, 2021)

Arabidopsis AtPRP17 functions in embryo development by regulating embryonic patterning - Dong Jie Shao; Yi Ming Wei; Zhong Qing Yu; Xinren Dai; Xin-Qi Gao (Planta, 2021)

Growth Differentiation Factor-15 Produces Analgesia by Inhibiting Tetrodotoxin-Resistant Nav1.8 Sodium Channel Activity in Rat Primary Sensory Neurons - Wei Lin; Wen-Wen Zhang; Ning Lyu; Hong Cao; Wen-Dong Xu; Yu-Qiu Zhang (Neuroscience Bulletin, 2021)
Growth differentiation factor 15 (GDF-15) is a member of the transforming growth factor-β superfamily. It is widely distributed in the central and peripheral nervous systems. Whether and how GDF-15 modulates nociceptive signaling remains unclear. Behaviorally, we found that peripheral GDF-15 significantly elevated nociceptive response thresholds to mechanical and thermal stimuli in naïve and arthritic rats. Electrophysiologically, we demonstrated that GDF-15 decreased the excitability of small-diameter dorsal root ganglia (DRG) neurons. Furthermore, GDF-15 concentration-dependently suppressed tetrodotoxin-resistant sodium channel Nav1.8 currents, and shifted the steady-state inactivation curves of Nav1.8 in a hyperpolarizing direction. GDF-15 also reduced window currents and slowed down the recovery rate of Nav1.8 channels, suggesting that GDF-15 accelerated inactivation and slowed recovery of the channel. Immunohistochemistry results showed that activin receptor-like kinase-2 (ALK2) was widely expressed in DRG medium- and small-diameter neurons, and some of them were Nav1.8-positive. Blockade of ALK2 prevented the GDF-15-induced inhibition of Nav1.8 currents and nociceptive behaviors. Inhibition of PKA and ERK, but not PKC, blocked the inhibitory effect of GDF-15 on Nav1.8 currents. These results suggest a functional link between GDF-15 and Nav1.8 in DRG neurons via ALK2 receptors and PKA associated with MEK/ERK, which mediate the peripheral analgesia of GDF-15.

Disruption of Circadian Clocks Promotes Progression of Alzheimer’s Disease in Diabetic Mice - Jiaojiao Huang; Xuemin Peng; Rongping Fan; Kun Dong; Xiaoli Shi; Shujun Zhang; Xuefeng Yu; Yan Yang (Molecular Neurobiology, 2021)

Identification and quantification of lead source in sediment in the northern East China Sea using stable lead isotopes - Yu Yu; Yingxia Li; Bing Li; Yichao Ren; Xiaoyu Dong (Journal of Oceanology and Limnology, 2021)

KGF Phage Model Peptide Accelerates Cutaneous Wound Healing in a Diabetic Rat Model - Hong Du; Guodong Song; Chunyan Cao; Dong Zhang; Panxi Yu; Xiaolei Jin; Xianlei Zong (International Journal of Peptide Research and Therapeutics, 2021)

Provenance and tectonic implications of early Paleozoic sedimentary rocks in the Central Altyn Tagh terrane, southeast of the Tarim craton - Qian Liu; Toshiaki Tsunogae; Guochun Zhao; Yigui Han; Zengchan Dong; Ningchao Zhou; Jinlong Yao; Peng Wang; Yu Wu (International Journal of Earth Sciences, 2021)

Apigenin Improves Hypertension and Cardiac Hypertrophy Through Modulating NADPH Oxidase-Dependent ROS Generation and Cytokines in Hypothalamic Paraventricular Nucleus - Hong-Li Gao; Xiao-Jing Yu; Han-Bo Hu; Qian-Wen Yang; Kai-Li Liu; Yan-Mei Chen; Yan Zhang; Dong-Dong Zhang; Hua Tian; Guo-Qing Zhu; Jie Qi; Yu-Ming Kang (Cardiovascular Toxicology, 2021)

Transcriptome analysis of flower color variation in five Rhododendron species (Ericaceae) - Zhiliang Li; Qiaofeng Yang; Xue Dong; Yu Zhu; Shuang Zhao; Wenying Zhang; Shuzhen Wang (Brazilian Journal of Botany, 2021)

Influencing factors and physiochemical changes of embryogenesis through in vitro isolated microspore culture in Brassica species - Yan-Qi Dong; Yu-Hong Gao; Te Zhao; Guang-Qian Ren; Yan-Li Liu; Bin Guan; Rong-Xian Jin; Fei Gao; Yan-Li Zhang; Xiu-Fang Tan; Hong-Cai Zhu; Yu-Hong Zhang; et al. (Biologia, 2021)

Detrimental impact of hypoxia on the mortality, growth, reproduction, and enzyme activities of planktonic mysid Neomysis awatschensis - Qiao-ning Wang; Xiao-dong Li; Tian Yan; Jing-jing Song; Ren-cheng Yu; Ming-jiang Zhou (Aquatic Ecology, 2021)

Reconstruction method of irregular seismic data with adaptive thresholds based on different sparse transform bases - Hu Zhao; Tun Yang; Yu-Dong Ni; Xing-Gang Liu; Yin-Po Xu; Yi-Lei Zhang; Guang-Rong Zhang (Applied Geophysics, 2021)

Establishment of a visualized isothermal nucleic acid amplification method for on‐site diagnosis of acute hepatopancreatic necrosis disease in shrimp farm - Xiaohan Yang; Yu Dong; Chao Ma; Yi Qiao; Ge Jiang; Shiqi Chen; Jingquan Dong; Hui Shen; Song Gao (Journal of Fish Diseases, 2021)
Acute hepatopancreatic necrosis disease (AHPND) is a significant deadly infectious disease in the shrimp farming industry, causing serious economic losses globally every year. Because of the rapid progress speed, lack of effective treatment and high mortality rate of AHPND, monitoring with frequent diagnostic tests is vital for a successful prevention. The conventional histopathological diagnosis fell far short of the requirement for efficient monitoring, and the polymerase chain reaction (PCR)‐based molecular diagnostic methods that rely on sophisticated thermocycler and trained personnel are hardly applicable in the field. Combining the recombinase polymerase amplification (RPA) and the lateral flow strips (LFSs), a diagnostic method suitable for on‐site everyday monitoring of AHPND has been established in this study. This RPA‐LFS method targeted the binary toxic photorhabdus insect‐related genes PirA and PirB on a virulence plasmid of the AHPND‐causative Vibrio parahaemolyticus strains. The diagnostic test was completed within 30 min at 37°C and showed good specificity and good sensitivity of 20 fg DNA of the AHPND shrimp or one colony‐forming unit of the causative bacterium per reaction, which was better than the administration‐approved standard AP4 assay. Crude templates from sample boiling could be directly used. Tests of clinical samples showed 100% consistency of this method with the standard AP4 assay. This RPA‐LFS method can be a good choice for on‐site diagnosis of AHPND with quick response time, easy procedure and low demand for resources, and should have significant value for the control of spreading of this dangerous disease in farmed shrimp.

Pyricularia sp. jiangsuensis , a new cryptic rice panicle blast pathogen from rice fields in Jiangsu Province, China - Yan Du; Zhongqiang Qi; Dong Liang; Junjie Yu; Mina Yu; Rongsheng Zhang; Huijuan Cao; Mingli Yong; Xiayan Pan; Xiaole Yin; Junqing Qiao; Youzhou Liu; et al. (Environmental Microbiology, 2021)
Summary Pyricularia oryzae is a multi‐host pathogen causing cereal disease, including the devastating rice blast. Panicle blast is a serious stage, leading to severe yield loss. Thirty‐one isolates (average 4.1%) were collected from the rice panicle lesions at nine locations covering Jiangsu province from 2010 to 2017. These isolates were characterized as Pyricularia sp. jiangsuensis distinct from known Pyricularia species. The representative strain 18‐2 can infect rice panicle, root and five kinds of grasses. Intriguingly, strain 18‐2 can co‐infect rice leaf with P . oryzae Guy11. The whole genome of P . sp. jiangsuensis 18‐2 was sequenced. Nine effectors were distributed in translocation or inversion region, which may link to the rapid evolution of effectors. Twenty‐one homologues of known blast‐effectors were identified in strain 18‐2, seven effectors including the homologues of SLP1 , BAS2 , BAS113 , CDIP2/3 , MoHEG16 and Avr‐Pi54 , were upregulated in the sample of inoculated panicle with strain 18‐2 at 24 hpi compared with inoculation at 8 hpi. Our results provide evidences that P . sp. jiangsuensis represents an addition to the mycobiota of blast disease. This study advances our understanding of the pathogenicity of P . sp. jiangsuensis to hosts, which sheds new light on the adaptability in the co‐evolution of pathogen and host.

Associations of Sleep Characteristics with Cerebrospinal Fluid sTREM2 in Cognitively Normal Older Adults: the CABLE Study - He-Ying Hu; Ling-Zhi Ma; Hao Hu; Yan-Lin Bi; Ya-Hui Ma; Xue-Ning Shen; Ya-Nan Ou; Qiang Dong; Lan Tan; Jin-Tai Yu (Neurotoxicity Research, 2021)

A novel artificial intelligence protocol to investigate potential leads for diabetes mellitus - Jia-Ning Gong; Lu Zhao; Guanxing Chen; Xu Chen; Zhi-Dong Chen; Calvin Yu-Chian Chen (Molecular Diversity, 2021)

Genetic diversity of potato virus Y potato isolates from Shandong province, China - Meng-Ao Jia; Lu Wang; Ji-Wu Zhang; Yu-Shuang Guo; Xiang-Dong Li; Yan-Ping Tian (Journal of Plant Pathology, 2021)

Hydrogen alleviates cell damage and acute lung injury in sepsis via PINK1/Parkin-mediated mitophagy - Hongguang Chen; Huaying Lin; Beibei Dong; Yaoqi Wang; Yonghao Yu; Keliang Xie (Inflammation Research, 2021)

Correlation study of parabens in urine, serum, and seminal plasma of adult men in Beijing, China - Lijia Yu; Fangda Peng; Dong Yuan; Linyuan Zhang; Ying Guo; Bing Chang; Xiaodong Shi; Chunguang Ding; Xiaowei Liang (Environmental Science and Pollution Research, 2021)

Residues and Safety Evaluation of Etoxazole, Bifenazate and Its Metabolite Bifenazate-diazene in Citrus Under Open-Field Conditions - Huizhen Hou; Xiaoxu Yu; Bizhang Dong; Jiye Hu (Bulletin of Environmental Contamination and Toxicology, 2021)

Porcine circovirus type 3 capsid protein induces NF-κB activation and upregulates pro-inflammatory cytokine expression in HEK-293T cells - Xianhui Liu; Hanqin Shen; Xinming Zhang; Tairun Liang; Yanfang Ban; Linyang Yu; Leyi Zhang; Yanling Liu; Jianguo Dong; Pengfei Zhang; Kaiqi Lian; Changxu Song (Archives of Virology, 2021)

Paracoccus binzhouensis sp. nov., isolated from activated sludge - Fang Wang; Xiao-Fan Gong; Dong Meng; Yu-Ling Liu; Peng-Fei Gu; Xiang-Yu Fan; Zhao-Song Huang; Zong-Jun Du; Qiang Li (Archives of Microbiology, 2021)

Effect of Modified Clay on the Growth Dynamics and Physio—Biochemical Response of Newly Hatched Larvae of the Marine Medaka (Oryzias melastigma) - Peipei Zhang; Xiuxian Song; Yue Zhang; Huihui Shen; Xueyi Dong; Jing Li; Zhiming Yu (Journal of Marine Science and Engineering, 2021)
An outbreak of harmful algal blooms (HABs) often leads to the death of fish and other marine organisms and causes serious losses to human economic activities. Modified clay (MC) technology is an effective way to control HABs. Although the material and preparation process are based on the premise of green and safety, the potential eco-environmental impacts of MC on non-target organisms should still have to receive attention before field applications can occur. Therefore, the effects of one commonly used modified clay, polyaluminum chloride-modified clay (PAC-MC), on the survival, growth, and oxidative stress of the marine medaka (Oryzias melastigma) were studied. The toxicity test results showed that the 96-h median lethal concentration (96-h LC50) of PAC-MC for newly hatched medaka larvae was 5.204 g/L, which was much higher than the concentration used on site (4–10 t/km2). Within the concentration range of PAC-MC used in this experiment (≤2 g/L), the morphology, heart rate, growth, and aluminum content of larvae did not change with the increase in the modified clay concentration. Low concentrations of PAC-MC (≤0.5 g/L) did not significantly affect catalase (CAT) activity, superoxide dismutase (SOD) activity, peroxidase (POD) activity, and the content of malondialdehyde (MDA), but higher concentrations of PAC-MC (such as 2 g/L) caused oxidative damage to the larvae and increased the antioxidant enzyme activity of the larvae. The present study revealed that under an effective dosage for treating harmful algal blooms on site, PAC-MC had no adverse effects on the survival, growth, oxidative stress, and aluminum content of the newly hatched marine medaka, which provides a scientific basis for the field application of modified clay.

Ectopic expression of DoFLS1 from Dendrobium officinale enhances flavonol accumulation and abiotic stress tolerance in Arabidopsis thaliana - Zhenming Yu; Wei Dong; Jaime A. Teixeira da Silva; Chunmei He; Can Si; Jun Duan (Protoplasma, 2021)

OsPUB41, a U-box E3 ubiquitin ligase, acts as a negative regulator of drought stress response in rice (Oryza Sativa L.) - Dong Hye Seo; Andosung Lee; Seong Gwan Yu; Li Hua Cui; Hye Jo Min; Seung Eun Lee; Na Hyun Cho; Sojung Kim; Hansol Bae; Woo Taek Kim (Plant Molecular Biology, 2021)

Predicting gene phenotype by multi-label multi-class model based on essential functional features - Lei Chen; Zhandong Li; Tao Zeng; Yu-Hang Zhang; Hao Li; Tao Huang; Yu-Dong Cai (Molecular Genetics and Genomics, 2021)

Analyses of the Impacts of Climate Change and Forest Fire on Cold Region Slopes Stability by Random Finite Element Method - Shaoyang Dong; Yusheng Jiang; Xiong Yu (Landslides, 2021)

Reference Electrode Standardization Interpolation Technique (RESIT): A Novel Interpolation Method for Scalp EEG - Li Dong; Lingling Zhao; Yufan Zhang; Xue Yu; Fali Li; Jianfu Li; Yongxiu Lai; Tiejun Liu; Dezhong Yao (Brain Topography, 2021)
“Bad channels” are common phenomena during scalp electroencephalography (EEG) recording that arise due to various technique-related reasons, and reconstructing signals from bad channels is an inevitable choice in EEG processing. However, current interpolation methods are all based on purely mathematical interpolation theory, ignoring the neurophysiological basis of the EEG signals, and their performance needs to be further improved, especially when there are many scattered or adjacent bad channels. Therefore, a new interpolation method, named the reference electrode standardization interpolation technique (RESIT), was developed for interpolating scalp EEG channels. Resting-state and event-related EEG datasets were used to investigate the performance of the RESIT. The main results showed that (1) assuming 10% bad channels, RESIT can reconstruct the bad channels well; (2) as the percentage of bad channels increased (from 2% to 85%), the absolute and relative errors between the true and RESIT-reconstructed signals generally increased, and the correlations between the true and RESIT signals decreased; (3) for a range of bad channel percentages (2% ~ 85%), the RESIT had lower absolute error (approximately 2.39% ~ 33.5% reduction), lower relative errors (approximately 1.3% ~ 35.7% reduction) and higher correlations (approximately 2% ~ 690% increase) than traditional interpolation methods, including neighbor interpolation (NI) and spherical spline interpolation (SSI). In addition, the RESIT was integrated into the EEG preprocessing pipeline on the WeBrain cloud platform ( https://webrain.uestc.edu.cn/ ). These results suggest that the RESIT is a promising interpolation method for both separate and simultaneous EEG preprocessing that benefits further EEG analysis, including event-related potential (ERP) analysis, EEG network analysis, and strict group-level statistics.

Multipath mitigation in GNSS precise point positioning based on trend-surface analysis and multipath hemispherical map - Ran Lu; Wen Chen; Danan Dong; Zhiren Wang; Chenglong Zhang; Yu Peng; Chao Yu (GPS Solutions, 2021)

TRIM21 inhibits porcine epidemic diarrhea virus proliferation by proteasomal degradation of the nucleocapsid protein - Hua Wang; Xiaoyong Chen; Ning Kong; Yajuan Jiao; Dage Sun; Sujie Dong; Wenzhen Qin; Huanjie Zhai; Lingxue Yu; Hao Zheng; Wu Tong; Hai Yu; et al. (Archives of Virology, 2021)

Acute exposure to microcystin-LR induces hepatopancreas toxicity in the Chinese mitten crab (Eriocheir sinensis) - Cheng Chi; Xia-Wei Yu; Cai-Yan Zhang; Jia-Dai Liu; Ming-Wen Ye; Ding-Dong Zhang; Wen-Bin Liu (Archives of Toxicology, 2021)

Distribution Characteristics, Pollution Assessment, and Source Identification of Heavy Metals in Soils Around a Landfill-Farmland Multisource Hybrid District - Honghua Liu; Yuan Wang; Jie Dong; Lixue Cao; Lili Yu; Jia Xin (Archives of Environmental Contamination and Toxicology, 2021)

The effect of consecutive ambient air pollution on the hospital admission from chronic obstructive pulmonary disease in the Chengdu region, China - Yi Zhang; Ziyue Wang; Yu Cao; Lifu Zhang; Guan Wang; Fangjie Dong; Ren Deng; Baogen Guo; Li Zeng; Peng Wang; Ruimei Dai; Yu Ran; et al. (Air Quality, Atmosphere & Health, 2021)

Photooxidation of Methacrolein in Fe(III)-Oxalate Aqueous System and Its Atmospheric Implication - Yu Wang; Jie Zhao; Huihui Liu; Yuan Li; Wenbo Dong; Yanlin Wu (Advances in Atmospheric Sciences, 2021)

Critical thinking on amyloid-beta-targeted therapy: challenges and perspectives - Bin-lu Sun; Yang Chen; Dong-yu Fan; Chi Zhu; Fan Zeng; Yan-jiang Wang (Science China Life Sciences, 2021)

MYC-associated protein X binding with the variant rs72780850 in RNA helicase DEAD box 1 for susceptibility to neuroblastoma - Yaqiong Jin; Jin Shi; Huanmin Wang; Jie Lu; Chenghao Chen; Yongbo Yu; Yaru Wang; Yeran Yang; Dong Ren; Qi Zeng; Xin Ni; Yongli Guo (Science China Life Sciences, 2021)

Genome-Wide Identification and Expression Analysis of Heavy Metal Stress–Responsive Metallothionein Family Genes in Nicotiana tabacum - Qin Yu; Linshen He; Chunsong Huo; Xiaohan Jiang; Hua Chen; Run Wang; Minzhi Tang; Ling Dong; Ji Chen; Yonghao Li; Shunqin Zhu; Wanhong Liu (Plant Molecular Biology Reporter, 2021)

Ziziphus jujuba Mill., a plant used as medicinal food: a review of its phytochemistry, pharmacology, quality control and future research - Shi-Jun Liu; Yan-Ping Lv; Zhi-Shu Tang; Yu Zhang; Hong-Bo Xu; Dong-Bo Zhang; Chun-Li Cui; Hong-Bo Liu; Huan-Huan Sun; Zhong-Xing Song; Si-Min Wei (Phytochemistry Reviews, 2021)

Serum Calcium Predicts Cognitive Decline and Clinical Progression of Alzheimer’s Disease - Ling-Zhi Ma; Zi-Xuan Wang; Zuo-Teng Wang; Xiao-He Hou; Xue-Ning Shen; Ya-Nan Ou; Qiang Dong; Lan Tan; Jin-Tai Yu (Neurotoxicity Research, 2021)

A comparative study of the recent most potent small-molecule PD-L1 inhibitors: what can we learn? - Mei Liu; Yu Zhang; Yu Guo; Jian Gao; Wenhai Huang; Xiaowu Dong (Medicinal Chemistry Research, 2021)

The role of HIF-1α in BCG-stimulated macrophages polarization and their tumoricidal effects in vitro - Pei Zhu; Yuyang Hou; Mengyan Tang; Zheng Jin; Youran Yu; Dong Li; Dongmei Yan; Zehua Dong (Medical Microbiology and Immunology, 2021)

Neuroprotective Effect of Phthalide Derivative CD21 against Ischemic Brain Injury:Involvement of MSR1 Mediated DAMP peroxiredoxin1 Clearance and TLR4 Signaling Inhibition - Xiao Zou; Xiao-Jia Yang; Yu-Miao Gan; Dong-Ling Liu; Chu Chen; Wei Duan; Jun-Rong Du (Journal of Neuroimmune Pharmacology, 2021)

Wound Healing Activity of Phage-Sisplayed TGF-β1 Model Peptide in Streptozotocin-Induced Diabetic Rats - Hong Du; Duyin Jiang; Guodong Song; Chunyan Cao; Dong Zhang; Panxi Yu; Chenzhi Lai; Xiaoshuang Guo; Xianlei Zong; Xiaolei Jin (International Journal of Peptide Research and Therapeutics, 2021)

Numerical simulation of hydraulic properties of soil in the GSPAC system under variable water-levels - Rui Dong; Yu-jiang He (Earth Science Informatics, 2021)

Influence of reservoir water level variations on slope stability and evaluation of landslide tsunami - Wen-Jie Xu; Yu-Jie Wang; Xue-Yang Dong (Bulletin of Engineering Geology and the Environment, 2021)

Altered structural and functional connectivity in CSF1R-related leukoencephalopathy - Fei-Xia Zhan; Ze-Yu Zhu; Qing Liu; Hai-Yan Zhou; Xing-Hua Luan; Xiao-Jun Huang; Xiao-Li Liu; Wo-Tu Tian; Shi-Ge Wang; Xiao-Xuan Song; Guang Chen; Ming-Liang Zhao; et al. (Brain Imaging and Behavior, 2021)

Assessment of the safety and anti‐inflammatory effects of three Bacillus strains in the respiratory tract - Hye‐Shin Kim; Karina Arellano; Haryung Park; Svetoslav D. Todorov; Bobae Kim; Hyeji Kang; Yu Jin Park; Dong Ho Suh; Eun Sung Jung; Yosep Ji; Wilhelm H. Holzapfel (Environmental Microbiology, 2021)
Summary Chronic respiratory diseases are part of accumulating health problems partly due to worldwide increase in air pollution. By their antimicrobial and immunomodulatory properties, some probiotics constitute promising alternatives for the prevention and treatment of chronic respiratory diseases. We have isolated Bacillus strains from Korean fermented foods and selected three potentially probiotic strains (two Bacillus subtilis and one Bacillus amyloliquefaciens ) based on safety, antimicrobial efficacy, activity against airborne pathogens and their immunomodulatory properties in vivo . Safety evaluation included in silico analysis for confirming absence of virulence genes. Safety for the respiratory tract was confirmed by an in vivo pathogenicity test using a murine model. Antimicrobial activity was displayed against several airborne pathogens. Potential antimicrobial metabolites such as 2,3‐butanediol and propylene glycol were identified as possible antagonistic agents. Immunomodulatory properties in vitro were confirmed by upregulation of IL‐10 expression in a macrophage cell line. Intranasal instillation and inhalation in an ovalbumin (OVA)‐induced lung inflammation murine model reduced T helper type 2 (Th2) cytokines at transcriptional and protein levels in the lungs. The safety and potentially beneficial role of these Bacillus strains could be demonstrated for the respiratory tract of a murine model.

Design of supercontinuum laser hyperspectral light detection and ranging (LiDAR) (SCLaHS LiDAR) - Guoqing Zhou; Xiang Zhou; Youjian Song; Donghui Xie; Long Wang; Guangjian Yan; Minglie Hu; Bowen Liu; Weidong Shang; Chenghu Gong; Cheng Wang; Huaguo Huang; et al. (International Journal of Remote Sensing, 2021)

Formyl tetrahydrofolate deformylase affects hydrogen peroxide accumulation and leaf senescence by regulating the folate status and redox homeostasis in rice - Erhui Xiong; Guojun Dong; Fei Chen; Chen Zhang; Shan Li; Yanli Zhang; Jahidul Islam Shohag; Xiaoe Yang; Yihua Zhou; Qian Qian; Limin Wu; Yanchun Yu (Science China Life Sciences, 2021)

NTP4 modulates miRNA accumulation via asymmetric modification of miRNA/miRNA* duplex - Wenwen Kong; Xianxin Dong; Yongbing Ren; Yuan Wang; Xintong Xu; Beixin Mo; Yu Yu; Xiaoyan Wang (Science China Life Sciences, 2021)

Synthesis and antitumor evaluation of (aryl)methyl-amine derivatives of dehydroabietic acid-based B ring-fused-thiazole as potential PI3K/AKT/mTOR signaling pathway inhibitors - Nai-Yuan Chen; Yu-Lan Xie; Guo-Dong Lu; Fang Ye; Xin-Yu Li; Yu-Wen Huang; Ming-Li Huang; Tie-Yu Chen; Cui-Ping Li (Molecular Diversity, 2021)

Establishment and characterization of 38 novel patient-derived primary cancer cell lines using multi-region sampling revealing intra-tumor heterogeneity of gallbladder carcinoma - Feiling Feng; Qingbao Cheng; Bin Li; Chen Liu; Huizhen Wang; Bin Li; Xiaoya Xu; Yong Yu; Zishuo Chen; Xiaobing Wu; Hua Dong; Kaijian Chu; et al. (Human Cell, 2021)
Gallbladder carcinoma (GBC) is a lethal biliary tract malignant neoplasm. Patient-derived primary cancer cell lines (PDPCs) are appropriate models to explore biological characteristics and potential therapeutics; however, there is a lack of PDPCs in GBC. In this study, we aimed to establish and characterize the GBC PDPCs, and further investigated the intra-tumor heterogeneity (ITH). Multi-region sampling (3–9 regions) of the operable tumor tissue samples was used to establish PDPCs. Short tandem repeat genotyping for cell authentication and karyotyping was performed, followed by whole-exome sequencing and RNA sequencing to assess the ITH at the genetic and transcriptional levels, respectively. Thirty-eight PDPCs were successfully established from seven GBC patients and characterized. ITH was observed with a median of 38.3% mutations being heterogeneous (range, 26.6–59.4%) across all patients. Similar with other tumor types, TP53 mutations were always truncal. In addition, there were three genes, KMT2C , CDKN2A , and ARID1A , with truncal mutations in at least two patients. A median of 370 differentially expressed genes (DEGs) was identified per patient. Distinct expression patterns were observed between major histocompatibility complex (MHC) class I and II genes. We found the expression of MHC class II genes in the PDPC samples was closely regulated by CIITA , while that of MHC class I genes were not correlated with CIITA expression. The PDPCs established from GBC patients can serve as novel in vitro models to identify the ITH, which may pave a crucial molecular foundation for enhanced understanding of tumorigenesis and progression.

Spatiotemporal variation of nitrogen and phosphorus and its main influencing factors in Huangshui River basin - Biqiong Dong; Tianling Qin; Yu Wang; Yan Zhao; Shanshan Liu; Jianming Feng; Chenhao Li; Xin Zhang (Environmental Monitoring and Assessment, 2021)
The foundation of managing excess nutrients in river is the identification of key physical processes and the control of decisive influencing factors. The existing studies seldom consider the influence of rainfall-runoff relationship and only focus on a few anthropogenic activities and natural attributes factors. To address this issue, a comprehensive set of influencing factors including rainfall-runoff relationship (represented by runoff coefficient), basic physical and chemical parameters of water quality, land use types, landscape patterns, topography, and socioeconomic development was constructed in this study. M–K test and cluster analysis were conducted to identify the temporal mutation and spatial clustering characteristics of NH 3 -N and TP in Huangshui River basin, respectively. Partial least squares regression was used to elucidate the linkages between water contaminants and the factors. As shown in the results, the temporal mutations of NH 3 -N and TP were obvious in the middle reaches, with 4 out of 7 catchments in the middle reaches have a larger number of mutations of NH 3 -N than other catchments. The cluster analysis results of NH 3 -N and TP among catchments were similar. This study also indicated that although the Huangshui River basin was located in the upper reaches of the Yellow River, the influences of rainfall-runoff relationship on spatiotemporal changes of NH 3 -N and TP in its sub-basins were limited. Only the temporal change of NH 3 -N in Jintan catchment in the upstream area was significantly affected by runoff coefficient. The indexes of proportion of water area (PWA), proportion of impervious area (PIA), and proportion of primary industry (PPI) were the top three influencing factors of temporal variation of NH 3 -N and TP for most catchments in the middle reaches. The temporal change of NH 3 -N in Jintan catchment in the upstream area was obviously affected by runoff coefficient. The spatial variation of NH 3 -N and TP were all affected by PWA and proportion of secondary industry significantly. The results of this study can provide theoretical basis and technical support for the control and management of nitrogen and phosphorus pollution in upper reaches of rivers.

Assessing ecological health of mangrove ecosystems along South China Coast by the pressure–state–response (PSR) model - Yu-Tu Wang; You-Shao Wang; Mei-Lin Wu; Cui-Ci Sun; Ji-Dong Gu (Ecotoxicology, 2021)

Characteristics of soil erosion and sediment size distribution for different land uses in the Chinese Mollisol region - Hai-ou Shen; Jun Feng; Dong-li Wang; Hong-li Li; Yu Wang (Journal of Mountain Science, 2021)

Wnt5a-induced docking of Plk1 on HEF1 promotes HEF1 translocation and tumorigenesis - Jeong-Ah Hwang; Ji Eun Yu; Sun-Ok Kim; Dong Hyun Kim; Kyoung Sang Cho; Kyung Ho Lee (Genes & Genomics, 2021)

Genome analysis of Salmonella phage vB_SalM_8-19 (genus Rosemountvirus) - Cong Cong; Wei Bing Dong; Cui Hui Jing; Yuan Yu Yu; Xu Yong Ping; Wang Li Li; Li Shu Ying; Li Ji Bin; Xu Mu; Li Xiao Yu (Archives of Microbiology, 2021)

In Silico Ventilation Within the Dose-Volume is Predictive of Lung Function Post-radiation Therapy in Patients with Lung Cancer - Yu Dong; H. Kumar; M. Tawhai; C. Veiga; A. Szmul; D. Landau; J. McClelland; L. Lao; K. S. Burrowes (Annals of Biomedical Engineering, 2021)
Lung cancer is a leading cause of death worldwide. Radiation therapy (RT) is one method to treat this disease. A common side effect of RT for lung cancer is radiation-induced lung damage (RILD) which leads to loss of lung function. RILD often compounds pre-existing smoking-related regional lung function impairment. It is difficult to predict patient outcomes due to large variability in individual response to RT. In this study, the capability of image-based modelling of regional ventilation in lung cancer patients to predict lung function post-RT was investigated. Twenty-five patient-based models were created using CT images to define the airway geometry, size and location of tumour, and distribution of emphysema. Simulated ventilation within the 20 Gy isodose volume showed a statistically significant negative correlation with the change in forced expiratory volume in 1 s 12-months post-RT ( p = 0.001, R = − 0.61). Patients with higher simulated ventilation within the 20 Gy isodose volume had a greater loss in lung function post-RT and vice versa. This relationship was only evident with the combined impact of tumour and emphysema, with the location of the emphysema relative to the dose-volume being important. Our results suggest that model-based ventilation measures can be used in the prediction of patient lung function post-RT.

Ammonia Toxicity Induces Oxidative Stress, Inflammatory Response and Apoptosis in Hybrid Grouper (♀ Epinephelus fuscoguttatus × ♂ E. lanceolatu) - Xiaobo Yan; Yu Chen; Xiaohui Dong; Beiping Tan; Hao Liu; Shuang Zhang; Shuyan Chi; Qihui Yang; Hongyu Liu; Yuanzhi Yang (Frontiers in Marine Science, 2021)
To study the effects of acute ammonia stress on the poisoning reaction of the hybrid grouper (♀ Epinephelus fuscoguttatus × ♂ E. lanceolatu ), 300 healthy grouper juveniles with an initial body weight of 51.4 ± 2.57 g were selected for an acute ammonia stress experiment using a half-lethal concentration of ammonia for 24, 48, 72, and 96 h with triplicate. The results show that (1) The half-lethal concentrations of ammonia for a hybrid grouper were 39.5 mg/L for 24 h, 27.3 mg/L for 48 h, 26.5 mg/L for 72 h, and 25.0 mg/L for 96 h, and the safe concentration was 2.50 mg/L. (2) The biochemical indices of the serum and livers of the groupers fluctuated under acute ammonia stress ( P < 0.05), and the contents of serum cortisol and lactate reached the maximum value in 72 h ( P < 0.05). (3) 24 h ammonia stress increased the activities of alkaline phosphatase, acid phosphatase, catalase, glutathione peroxidase, superoxide dismutase, lysozyme, and the content of immunoglobulin M in the liver ( P < 0.05). Meanwhile, all ammonia-stressed fish groups had an increased amount of malondialdehyde in the liver ( P < 0.05). (4) The ammonia poisoning caused significantly up-regulation of antioxidant genes, inflammatory cytokines, and apoptosis genes ( P < 0.05), and the expression of inflammatory cytokines and apoptosis genes were the highest in 24 h ammonia stress group. (5) The ammonia content in the water changed the abundance and evenness of intestinal microbes in grouper, mainly in that ammonia stress significantly increased the relative abundance of fusobacteria, but significantly decreased the relative abundance of gemmatimonadetes ( P < 0.05). It was speculated that apoptosis induced by ammonia poisoning in grouper may be related to oxidative stress and the activation of inflammatory factors, and excessive inflammatory stress may be one of the causes of ammonia poisoning in the hybrid grouper.

Abundance-weighted plant functional trait variation differs between terrestrial and wetland habitats along wide climatic gradients - Yu-Kun Hu; Guo-Fang Liu; Xu Pan; Yao-Bin Song; Ming Dong; Johannes H. C. Cornelissen (Science China Life Sciences, 2021)

Combined Use of Bacillus subtilis yb-114,246 and Bacillus licheniformis yb-214,245 Improves Body Growth Performance of Chinese Huainan Partridge Shank Chickens by Enhancing Intestinal Digestive Profiles - Jiajun Yang; Kehe Huang; Jing Wang; Dong Wu; Zongliang Liu; Pengcheng Yu; Zhanyong Wei; Fu Chen (Probiotics and Antimicrobial Proteins, 2021)

Associations between SNP83 of phosphodiesterase 4D gene and carotid atherosclerosis in a southern Chinese Han population: a case–control study - Liu-yu Liu; Dong-can Mo; Jian-li Li; Yi-ying Jiang; Guo-qiu Zhou; Dong-dong Jiang; Li-jie Chen; Xiao-ju Wu; Jiao-xing Li; Man Luo (Mammalian Genome, 2021)

EEG-Based Anxious States Classification Using Affective BCI-Based Closed Neurofeedback System - Chao Chen; Xuecong Yu; Abdelkader Nasreddine Belkacem; Lin Lu; Penghai Li; Zufeng Zhang; Xiaotian Wang; Wenjun Tan; Qiang Gao; Duk Shin; Changming Wang; Sha Sha; et al. (Journal of Medical and Biological Engineering, 2021)

The prevalence and risks of major comorbidities among inpatients with pulmonary tuberculosis in China from a gender and age perspective: a large-scale multicenter observational study - Wanli Kang; Jian Du; Song Yang; Jiajia Yu; Hongyan Chen; Jianxiong Liu; Jinshan Ma; Mingwu Li; Jingmin Qin; Wei Shu; Peilan Zong; Yi Zhang; et al. (European Journal of Clinical Microbiology & Infectious Diseases, 2021)

Chelativorans alearense sp. nov., A Novel Bacterial Species Isolated From Soil in Alear, China - Dong Meng; Yu-Ling Liu; Peng-Fei Gu; Xiang-Yu Fan; Zhao-Song Huang; Yan Ji; Wei-Min Li; Zong-Jun Du; Qiang Li (Current Microbiology, 2021)

The changes of brain functional networks in young adult smokers based on independent component analysis - XianFu Wang; Ting Xue; Fang Dong; Yangding Li; Dongdong Xie; Chang Liu; Ming Zhang; Yanzhi Bi; Kai Yuan; Dahua Yu (Brain Imaging and Behavior, 2021)

The effect of conservation tillage in managing climate change in arid and semiarid areas—a case study in Northwest China - Lin Dong; Tong Si; Yu-e Li; Xiao-Xia Zou (Mitigation and Adaptation Strategies for Global Change, 2021)

The dynamics in rhizosphere microbial communities under bacterial wilt resistance by mulberry genotypes - Zhaoxia Dong; Yao Guo; Cui Yu; Zhu Zhixian; Mo Rongli; Wen Deng; Yong Li; Xingming Hu (Archives of Microbiology, 2021)

Characterization and complete genome analysis of Bacillus velezensis CB6 revealed ATP synthase subunit α against foodborne pathogens - Haipeng Zhang; Guan-yi Xu; Changsi Mao; Yuxuan Xu; Wenlong Dong; Muhammad Inam; Siyu Pan; Renge Hu; Yiming Wang; Yu Wang; Hongxia Ma; Lingcong Kong (Archives of Microbiology, 2021)

Selective regulation in ribosome biogenesis and protein production for efficient viral translation - Hui-Jun Dong; Rui Zhang; Yu Kuang; Xiao-Jia Wang (Archives of Microbiology, 2021)

Nesterenkonia haasae sp. nov., an alkaliphilic actinobacterium isolated from a degraded pasture in Songnen Plain - Shuang Wang; Lei Sun; Dan Wei; Nimaichand Salam; Bao-Zhu Fang; Zhou-Yan Dong; Xiao-Yu Hao; Mingyi Zhang; Zhe Zhang; Wen-Jun Li (Archives of Microbiology, 2021)

Thermaurantiacus tibetensis gen. nov., sp. nov., a novel moderately thermophilic bacterium isolated from hot spring microbial mat in Tibet - Yu-Zhen Ming; Lan Liu; Ai-Ping Lv; Wen-Dong Xian; Ze-Tao Liu; Meng-Meng Li; Jian-Yu Jiao; Bao-Zhu Fang; Wen-Jun Li (Antonie van Leeuwenhoek, 2021)

Reduction in extreme climate events and potential impacts by the use of technological advances - Ting Wei; Changxin Liu; Wenjie Dong; Haipeng Yu; Shili Yang; Qing Yan; Zhixin Hao (International Journal of Climatology, 2021)
Technological advances have the potential to balance climate change mitigation and economic development. However, it remains unclear how much technological advances alone can mitigate climate change and the associated economic losses in the future. Through designing a suite of technological advances scenarios and using an earth system model with an integrated assessment model, we illustrate that rapid technological progress without production control might achieve the 2°C global warming target in the 2100s. Relative to a world of stagnant technology, the frequency (intensity) of extreme warm events at the end of the 21st century (2081–2100) would be reduced by ∼21% (5.5°C) via rapid technological advances, with a reduction in extreme precipitation (droughts) by ∼41% (10 times). Furthermore, fast technological advances may reduce the global economic losses linked with climate change at 2081–2100 by ∼21% and those in China related to floods (droughts) by 86% (67%). Our results highlight the potential of technological advances to fill the emission gap between the Paris Agreement and unconditional Nationally Determined Contributions and hence to efficiently mitigate global warming.

Dominant modes of interannual variability in precipitation over the Hengduan Mountains during rainy seasons - Weichen Tao; Gang Huang; Danhong Dong; Pengfei Wang; Ting Yu; Hainan Gong (International Journal of Climatology, 2021)
Present study investigates the dominant modes of interannual variability in precipitation over the Hengduan Mountains (HM) during rainy seasons. The leading two empirical orthogonal function (EOF) modes of HM precipitation explain 28.4 and 13.9% of the total variance, respectively. Positive EOF1 phase features enhanced precipitation anomalies over the southern HM, and a dipole structure with wet anomalies occupying large areas from the YunGui plateau to Tibetan Plateau is observed in positive EOF2 phase. Analysis of moisture budget and omega equation indicate the importance of leading EOF modes related circulation anomalies, which bring the horizontal warm advection to the HM, favouring the anomalous upward motions and precipitation increase there. For EOF1, the HM is controlled by an anomalous quasi‐barotropic cyclone. This cyclone is one part of a zonally oriented barotropic wave‐like pattern highly resembling the Silk Road pattern. Besides, the SST anomalies over the Indo‐Pacific sector are similar to the decaying phase of La Niña, which induces the wet anomalies and further triggers the anomalous lower‐level cyclone as a Rossby wave response. For EOF2, an anomalous cyclone appears over the Northeast Asia from lower to upper levels, and southerly wind anomalies prevail over the HM. The North Atlantic Oscillation and its coupled tripole SST pattern trigger a zonal wave‐like pattern at middle and high latitudes emanating from the Central Europe, across Mongolia to Northeast Asia. Moreover, the SST anomalies over the Indo‐Pacific sector resemble the developing phase of El Niño, which induces the meridional Pacific‐Japan/East Asia‐Pacific teleconnection from tropical NWP to Northeast Asia.

Decreased grain size1, a C3HC4-type RING protein, influences grain size in rice (Oryza sativa L.) - Xingjie Zhu; Shengzhong Zhang; Yaping Chen; Changlin Mou; Yunshuai Huang; Xi Liu; Jingli Ji; Jiangfeng Yu; Qixian Hao; Chunyan Yang; Mengying Cai; Thanhliem Nguyen; et al. (Plant Molecular Biology, 2021)

Sri Lanka seasonal warm pools - Guoqing Han; Changming Dong; Jingsong Yang; Yu Liu (Journal of Oceanology and Limnology, 2021)

Antimonate removal by diatomite modified with Fe-Mn oxides: application and mechanism study - Qiu-Yi Dong; Yu-Chun Fang; Bin Tan; Aura Ontiveros-Valencia; Ang Li; He-Ping Zhao (Environmental Science and Pollution Research, 2021)

Response of sulfhydryl compounds in subcells of Cladophora rupestris under Pb stress - Qiu-yu Chen; Lei Liu; Liu Yang; Bei Dong; Yi-zheng Wen; Zhe Zhang; Qian Zhang; De-ju Cao (Environmental Science and Pollution Research, 2021)

An analysis on the adoption of an interregional carbon emission reduction allocation approach in the context of China’s interprovincial carbon emission transfer - Yang Yang; Suocheng Dong; Fujia Li; Hao Cheng; Zehong Li; Yu Li; Shantong Li (Environment, Development and Sustainability, 2021)

Automatic mapping of river canyons using a digital elevation model and vector river data - Shi-Yu Xu; An-Bo Li; Tian-Tian Dong; Xian-Li Xie (Earth Science Informatics, 2021)

Alcanivorax profundimaris sp. nov., a Novel Marine Hydrocarbonoclastic Bacterium Isolated from Seawater and Deep-Sea Sediment - Chunming Dong; Qiliang Lai; Xiupian Liu; Li Gu; Yu Zhang; Zhangxian Xie; Dazhi Wang; Zongze Shao (Current Microbiology, 2021)

Influence of the roots of mixed-planting species on the shear strength of saline loess soil - Ya-bin Liu; Xia-song Hu; Dong-mei Yu; Hai-li Zhu; Guo-rong Li (Journal of Mountain Science, 2021)

Chelativorans xinjiangense sp. nov., a novel bacterial species isolated from soil in Xinjiang, China - Dong Meng; Yu-Ling Liu; Peng-Fei Gu; Xiang-Yu Fan; Zhao-Song Huang; Yan Ji; Wei-Min Li; Zong-Jun Du; Qiang Li (Archives of Microbiology, 2021)