Design of overburden thickness for underground arsenals based on numerical simulation of underground explosion caves - Xingui Zhang; Jiaxiong Zhu; Li’e Yan; Yi Zeng; Qingsheng Chen; Mangyuan Li (Arabian Journal of Geosciences, 2021)

Fractal approach in expansive clay-based materials with special focus on compacted GMZ bentonite in nuclear waste disposal: a systematic review - Fazal E. Jalal; Yongfu Xu; Xiaoyue Li; Babak Jamhiri; Mudassir Iqbal (Environmental Science and Pollution Research, 2021)

Molecular Identification of Dried Shellfish Products Sold on the Market Using DNA Barcoding - Shao’e Sun; Xiaojie Zhang; Lingfeng Kong; Qi Li (Journal of Ocean University of China, 2021)

The first complete genome sequence of an iflavirus from the endoparasitoid wasp Tetrastichus brontispae - E Meng; Baozhen Tang; Jingyi Li; Lang Fu; Youming Hou (Archives of Virology, 2021)

Pathogenic variants in CDH11 impair cell adhesion and cause Teebi hypertelorism syndrome - Dong Li; Michael E. March; Paola Fortugno; Liza L. Cox; Leticia S. Matsuoka; Rosanna Monetta; Christoph Seiler; Louise C. Pyle; Emma C. Bedoukian; María José Sánchez-Soler; Oana Caluseriu; Katheryn Grand; et al. (Human Genetics, 2021)

Does It Pay to Conduct Midrotation Competition Control and/or Fertilization? Results from Two Thinned Loblolly Pine Studies in the Coastal Plain of Georgia - Yanshu Li; E David Dickens; Matthew Sault; Jacek P Siry; Robert L Izlar; David C Clabo; William G Tyson (Journal of Forestry, 2021)
The effects of midrotation competition control and fertilization were studied in two loblolly pine stands in the Coastal Plain of Georgia. The use of fertilizer or herbicide alone did not enhance wood yields above the control, which negates the cost spent to conduct these practices. The combined treatment of fertilization and herbicide promoted higher average pine annual increment and greater proportion of sawtimber. Site limiting factors, most likely both competing woody vegetation and low nutrient status, largely determined the effectiveness and priority of midrotation treatments. The economic returns of the combined treatment varied considerably depending on stumpage prices, treatment costs, and magnitude and duration of the growth response. Sawtimber prices (absolute value and relative to pulpwood and chip-n-saw) play a critical role in the marginal returns of midrotation treatments. Continued depressed sawtimber prices will discourage private landowners from investing in midrotation vegetation control and fertilization.

Ivermectin effectively inhibits hepatitis E virus replication, requiring the host nuclear transport protein importin α1 - Yunlong Li; Zhijiang Miao; Pengfei Li; Ruyi Zhang; Denis E. Kainov; Zhongren Ma; Robert A. de Man; Maikel P. Peppelenbosch; Qiuwei Pan (Archives of Virology, 2021)
We show that ivermectin, an FDA-approved anti-parasitic drug, effectively inhibits infection with hepatitis E virus (HEV) genotypes 1 and 3 in a range of cell culture models, including hepatic and extrahepatic cells. Long-term treatment showed no clear evidence of the development of drug resistance. Gene silencing of importin-α1, a cellular target of ivermectin and a key member of the host nuclear transport complex, inhibited viral replication and largely abolished the anti-HEV effect of ivermectin.

Lipophilic Salts and Lipid-Based Formulations: Enhancing the Oral Delivery of Octreotide - Peng Li; Leigh Ford; Shadabul Haque; Mitchell P. McInerney; Hywel D. Williams; Peter J. Scammells; Philip E. Thompson; Vincent Jannin; Christopher J. H. Porter; Hassan Benameur; Colin W. Pouton (Pharmaceutical Research, 2021)

The LBPM software package for simulating multiphase flow on digital images of porous rocks - James E. McClure; Zhe Li; Mark Berrill; Thomas Ramstad (Computational Geosciences, 2021)

Variations of carbon allocation and turnover time across tropical forests - Hui Yang; Philippe Ciais; Yilong Wang; Yuanyuan Huang; Jean‐Pierre Wigneron; Ana Bastos; Jérôme Chave; Jinfeng Chang; Christopher E. Doughty; Lei Fan; Daniel Goll; Emilie Joetzjer; et al. (Global Ecology and Biogeography, 2021)
Aim The carbon sink in tropical forests is a highly uncertain component of the global carbon budget. An understanding of the processes controlling this sink requires better quantification of carbon allocation, stocks and turnover times. Location Tropical forests. Time period 2010–2017. Major taxa studied Tropical forest ecosystem. Methods We develop a novel data assimilation system using satellite‐based annual above‐ground biomass derived from L‐band vegetation optical depth with 25 km × 25 km grid spacing, together with leaf area, to constrain the 25 km × 25 km carbon allocation patterns of net primary productivity (NPP) into the wood, leaf and root pools, and their turnover times. Our average data‐driven estimates of these variables are broadly consistent with independent ground‐based estimates of NPP allocation and wood turnover from forest inventory plots. Results In tropical forest, on average, the NPP allocation into wood (0.30 ± 0.04) is significantly higher than that into leaves (0.24 ± 0.07). From the wet to dry tropics, forest NPP allocation into both wood and leaves declines slightly. The turnover times of forest leaf pools exhibit little spatial variation, whereas the turnover times of wood pools in Africa (median and interquartile range: years) are slightly longer than those in South America ( years) and Southeast Asia ( years). Our datasets reveal emergent trade‐offs across climatic and vegetation gradients between growth and life span/turnover for both wood and leaves. The spatial gradients of NPP allocation to wood/leaves are associated with canopy height, adjusted by climate condition and nutrient acquisition. The spatial gradients of wood and leaf turnover times are influenced mainly by climate and leaf characteristics. Main conclusions Our data‐driven estimates of carbon allocation and turnover times provide a basis for more detailed exploration of these mechanisms in field studies. This highlights that improved model representation of carbon allocation and turnover is necessary for more accurate prediction of future carbon dynamics.

Dose-Dependent Effects of Di-(2-Ethylhexyl) Phthalate (DEHP) in Mussel Mytilus galloprovincialis - Hai’e Xu; Wanshuang Cao; Hongliang Sun; Shougang Zhang; Pan Li; Surong Jiang; Caiyun Zhong (Frontiers in Marine Science, 2021)
Phthalic acid esters (PAEs) are environmental organic pollutants that are ubiquitous in the ocean, and di-(2-ethylhexyl) phthalate (DEHP) is the most widely used PAE. The environmental concentration of DEHP was reported to be up to 42.52 μg/L in seawater in the estuaries located in Jiaozhou Bay along the Yellow Sea. DEHP has been investigated with respect to its toxicity in marine organisms. However, evidence on the dose-dependent effects of DEHP remains contradictory and limited. We used marine mussel Mytilus galloprovincialis as the experimental animal to study the dose-dependent effects of various levels of exposure to DEHP (concentrations of 4, 12, 36, 108, and 324 μg/L). These effects and the underlying mechanisms were elucidated by the levels of antioxidant enzyme activity, gene expression, and metabolite. The results indicated that, at environmentally relevant concentrations (12 and 36 μg/L), DEHP induced significant hormetic effects. This was indicated by the U-shaped or inverted U-shaped responses of the gene expression levels related to stress response ( CAT , GST , and MgGLYZ ) and antioxidant enzyme activities (SOD and CAT). The metabolic profiles revealed that DEHP generally caused monophasic response in osmotic regulation (homarine) and biphasic response (hormesis) in energy metabolism (glucose, glycogen, and amino acids), respectively. These findings can aid in ecological risk assessment with respect to DEHP and the determination of hormetic dose responses.

A Multifaceted Approach to Advance Oil Spill Modeling and Physical Oceanographic Research at the United States Bureau of Ocean Energy Management - Zhen Li; Caryn Smith; Christopher DuFore; Susan F. Zaleski; Guillermo Auad; Walter Johnson; Zhen-Gang Ji; S. E. O’Reilly (Journal of Marine Science and Engineering, 2021)
The Environmental Studies Program (ESP) at the United States Bureau of Ocean Energy Management (BOEM) is funded by the United States Congress to support BOEM’s mission, which is to use the best available science to responsibly manage the development of the Nation’s offshore energy and mineral resources. Since its inception in 1973, the ESP has funded over $1 billion of multidisciplinary research across four main regions of the United States Outer Continental Shelf: Gulf of Mexico, Atlantic, Alaska, and Pacific. Understanding the dynamics of oil spills and their potential effects on the environment has been one of the primary goals of BOEM’s funding efforts. To this end, BOEM’s ESP continues to support research that improves oil spill modeling by advancing our understanding and the application of meteorological and oceanographic processes to improve oil spill modeling. Following the Deepwater Horizon oil spill in 2010, BOEM has invested approximately $28 million on relevant projects resulting in 73 peer-reviewed journal articles and 42 technical reports. This study describes the findings of these projects, along with the lessons learned and research information needs identified. Additionally, this paper presents a path forward for BOEM’s oil spill modeling and physical oceanographic research.

Isolation and identification of antimicrobial metabolites from sea anemone-derived fungus Emericella sp. SMA01 - Yang Yue; Huahua Yu; Rongfeng Li; Linfeng Hu; Song Liu; Rong’e Xing; Pengcheng Li (Journal of Oceanology and Limnology, 2021)

Whole genome sequencing analysis of multidrug-resistant tuberculosis in Singapore, 2006–2018 - Cynthia B. E. Chee; Leo K. Y. Lim; Rick T. H. Ong; Li Hwei Sng; Li Yang Hsu; Vernon J. M. Lee; Yee Tang Wang (European Journal of Clinical Microbiology & Infectious Diseases, 2021)

Invasion of an inconspicuous ambrosia beetle and fungus may affect wood decay in Southeastern North America - Jiri Hulcr; Demian F. Gomez; James Skelton; Andrew J. Johnson; Sawyer Adams; You Li; Michelle A. Jusino; Matthew E. Smith (Biological Invasions, 2021)

Soil engineering by ants facilitates plant compensation for large herbivore removal of aboveground biomass - Zhiwei Zhong; Xiaofei Li; Dirk Sanders; Yiming Liu; Ling Wang; Yvette K. Ortega; Dean E. Pearson; Deli Wang (Ecology, 2021)
The interplay between top‐down and bottom‐up processes determines ecosystem productivity. Yet, the factors that mediate the balance between these opposing forces remain poorly understood. Furthering this challenge, complex and often cryptic factors like ecosystem engineering and trait‐mediated interactions may play major roles in mediating the outcomes of top‐down and bottom‐up interactions. In semiarid grasslands of northeastern China, we conducted a large‐scale, three‐year experiment to evaluate how soil engineering by ants and plasticity in plants independently and jointly influenced the top‐down effects of grazing by a ubiquitous herbivore (cattle) on aboveground standing biomass of the dominant perennial grass, Leymus chinensis . Herbivory had strong top‐down effects, reducing L. chinensis AB by 25% relative to baseline levels without cattle or ants. In contrast, soil engineering by ants facilitated weak bottom‐up effects in the absence of herbivory. However, in the presence of herbivory, soil engineering effects were strong enough to fully offset herbivore removal of aboveground biomass. This outcome was mediated by L. chinensis ’s plasticity in reallocating growth from below‐ to aboveground biomass, a result linked to additive effects of engineers and herbivores increasing soil N availability and engineering effects improving soil structure. Soil engineering increased soil N by 12%, promoting aboveground biomass. Herbivores increased soil N by 13% via defecation, but this increase failed to offset their reductions in aboveground biomass in isolation. However, when combined, engineers and herbivores increased soil N by 26% and engineers improved soil bulk density, facilitating L. chinensis to shift resource allocations from below‐ to aboveground biomass sufficiently to fully offset herbivore suppression of aboveground biomass. Our results demonstrate that soil engineering and trait‐mediated effects of plant plasticity can strongly mediate the outcome of top‐down and bottom‐up interactions. These cryptic but perhaps ubiquitous processes may help to explain the long‐debated phenomenon of plant compensatory responses to large grazers.

A Photopolymerized Semi-Interpenetrating Polymer Networks-Based Hydrogel Incorporated with Nanoparticle for Local Chemotherapy of Tumors - Yeying Wang; Qilong Li; Jing-e Zhou; Jingwen Tan; Minghao Li; Nan Xu; Feng Qu; Jian Chen; Ji Li; Jing Wang; Zhiqiang Liang; Lei Yu; et al. (Pharmaceutical Research, 2021)

The Fracture Induced Electromagnetic Radiation: Approach and Protocol for the Stress State Assessment for Mining - V. Frid; E. Y. Wang; S. N. Mulev; D. X. Li (Geotechnical and Geological Engineering, 2021)

QTL mapping of lentil anthracnose (Colletotrichum lentis) resistance from Lens ervoides accession IG 72815 in an interspecific RIL population - Tadesse S. Gela; Chu Shin Koh; Carolyn T. Caron; Li-An Chen; Albert Vandenberg; Kirstin E. Bett (Euphytica, 2021)

Toward a global and reproducible science for brain imaging in neurotrauma: the ENIGMA adult moderate/severe traumatic brain injury working group - Alexander Olsen; Talin Babikian; Erin D. Bigler; Karen Caeyenberghs; Virginia Conde; Kristen Dams-O’Connor; Ekaterina Dobryakova; Helen Genova; Jordan Grafman; Asta K. Håberg; Ingrid Heggland; Torgeir Hellstrøm; et al. (Brain Imaging and Behavior, 2021)
The global burden of mortality and morbidity caused by traumatic brain injury (TBI) is significant, and the heterogeneity of TBI patients and the relatively small sample sizes of most current neuroimaging studies is a major challenge for scientific advances and clinical translation. The ENIGMA (Enhancing NeuroImaging Genetics through Meta-Analysis) Adult moderate/severe TBI (AMS-TBI) working group aims to be a driving force for new discoveries in AMS-TBI by providing researchers world-wide with an effective framework and platform for large-scale cross-border collaboration and data sharing. Based on the principles of transparency, rigor, reproducibility and collaboration, we will facilitate the development and dissemination of multiscale and big data analysis pipelines for harmonized analyses in AMS-TBI using structural and functional neuroimaging in combination with non-imaging biomarkers, genetics, as well as clinical and behavioral measures. Ultimately, we will offer investigators an unprecedented opportunity to test important hypotheses about recovery and morbidity in AMS-TBI by taking advantage of our robust methods for large-scale neuroimaging data analysis. In this consensus statement we outline the working group’s short-term, intermediate, and long-term goals.

The effect of conservation tillage in managing climate change in arid and semiarid areas—a case study in Northwest China - Lin Dong; Tong Si; Yu-e Li; Xiao-Xia Zou (Mitigation and Adaptation Strategies for Global Change, 2021)

Initial ingestion of CMV-infected plants reduces subsequent aphid performance - Xiao-bin Shi; Jun Deng; Zhuo Zhang; Shuo Yan; Li-min Zheng; Shu-e Sun; Yang Gao; Xu-guo Zhou; De-yong Zhang; Yong Liu (Arthropod-Plant Interactions, 2021)

NABat: A top-down, bottom-up solution to collaborative continental-scale monitoring - Brian E. Reichert; Mylea Bayless; Tina L. Cheng; Jeremy T. H. Coleman; Charles M. Francis; Winifred F. Frick; Benjamin S. Gotthold; Kathryn M. Irvine; Cori Lausen; Han Li; Susan C. Loeb; Jonathan D. Reichard; et al. (Ambio, 2021)
Collaborative monitoring over broad scales and levels of ecological organization can inform conservation efforts necessary to address the contemporary biodiversity crisis. An important challenge to collaborative monitoring is motivating local engagement with enough buy-in from stakeholders while providing adequate top-down direction for scientific rigor, quality control, and coordination. Collaborative monitoring must reconcile this inherent tension between top-down control and bottom-up engagement. Highly mobile and cryptic taxa, such as bats, present a particularly acute challenge. Given their scale of movement, complex life histories, and rapidly expanding threats, understanding population trends of bats requires coordinated broad-scale collaborative monitoring. The North American Bat Monitoring Program (NABat) reconciles top-down, bottom-up tension with a hierarchical master sample survey design, integrated data analysis, dynamic data curation, regional monitoring hubs, and knowledge delivery through web-based infrastructure. NABat supports collaborative monitoring across spatial and organizational scales and the full annual lifecycle of bats.

Regional Differences in Antifungal Susceptibility of the Prevalent Dermatophyte Trichophyton rubrum - Y. Jiang; W. Luo; P. E. Verweij; Y. Song; B. Zhang; Z. Shang; A. M. S. Al-Hatmi; S. A. Ahmed; Z. Wan; R. Li; G. S. de Hoog (Mycopathologia, 2021)
In vitro susceptibility testing for Trichophyton rubrum has shown resistance to terbinafine, azoles and amorolfine, locally, but epidemiological cutoffs are not available. In order to assess the appropriateness of current first-line antifungal treatment for T. rubrum in China, we characterized antifungal susceptibility patterns of Chinese T. rubrum strains to nine antifungals and also described the upper limits of wild-type (WT) minimal inhibitory concentrations (MIC) (UL-WT) based on our study and another six studies published during the last decades. Sixty-two clinical isolates originating from seven provinces in China were identified as T. rubrum sensu stricto; all Chinese strains showed low MICs to eight out of nine antifungal drugs. Terbinafine (TBF) showed the lowest MICs of all antifungal classes tested in both the Chinese and global groups, with a 97.5% UL-WT MIC-value of 0.03 mg/L. No non-WT isolates were observed for TBF in China, but were reported in 18.5% of the global group. Our study indicated that TBF was still the most active drug for Chinese T. rubrum isolates, and all strains were within the WT-population. TBF therefore remains recommended for primary therapy to dermatophytosis caused by T. rubrum in China now, but regular surveillance of dermatophytes and antifungal susceptibility is recommended.

EPG-recorded Feeding Behaviors Reveal Adaptability and Competitiveness in Two Species of Bemisia tabaci (Hemiptera: Aleyrodidae) - Shao-hua Lu; Jing-jing Li; Run-e Bai; Feng-ming Yan (Journal of Insect Behavior, 2021)

Responses of submerged macrophytes and periphyton to warming under two nitrogen scenarios: A microcosm study - Yang Liu; Celina Aznarez; Erik Jeppesen; Hu He; Wei Li; Eti E. Levi; Juan Pablo Pacheco; Yu Cao (Hydrobiologia, 2021)

Mechanism of pore water seepage in soil reinforced by step vacuum preloading - Wenchong Shan; Hui-e Chen; Xiaoqing Yuan; Wenliang Ma; Hui Li (Bulletin of Engineering Geology and the Environment, 2021)

Regional Comparison of Snow Leopard (Panthera uncia) Diet using DNA Metabarcoding - Charlotte E. Hacker; Matthew Jevit; Shafqat Hussain; Ghulam Muhammad; Bariushaa Munkhtsog; Bayaraa Munkhtsog; Yuguang Zhang; Diqiang Li; Yanlin Liu; John D. Farrington; Farida Balbakova; Azat Alamanov; et al. (Biodiversity and Conservation, 2021)

Host genetics and gut microbiota cooperatively contribute to azoxymethane-induced acute toxicity in Collaborative Cross mice - Chenhan Zhong; Li He; Sun-Young Lee; Hang Chang; Yuqing Zhang; David W. Threadgill; Ying Yuan; Fuling Zhou; Susan E. Celniker; Yankai Xia; Antoine M. Snijders; Jian-Hua Mao (Archives of Toxicology, 2021)

Moisture availability mediates the relationship between terrestrial gross primary production and solar‐induced chlorophyll fluorescence: Insights from global‐scale variations - Anping Chen; Jiafu Mao; Daniel Ricciuto; Jingfeng Xiao; Christian Frankenberg; Xing Li; Peter E. Thornton; Lianhong Gu; Alan K. Knapp (Global Change Biology, 2021)
Effective use of solar‐induced chlorophyll fluorescence (SIF) to estimate and monitor gross primary production (GPP) in terrestrial ecosystems requires a comprehensive understanding and quantification of the relationship between SIF and GPP. To date, this understanding is incomplete and somewhat controversial in the literature. Here we derived the GPP/SIF ratio from multiple data sources as a diagnostic metric to explore its global‐scale patterns of spatial variation and potential climatic dependence. We found that the growing season GPP/SIF ratio varied substantially across global land surfaces, with the highest ratios consistently found in boreal regions. Spatial variation in GPP/SIF was strongly modulated by climate variables. The most striking pattern was a consistent decrease in GPP/SIF from cold‐and‐wet climates to hot‐and‐dry climates. We propose that the reduction in GPP/SIF with decreasing moisture availability may be related to stomatal responses to aridity. Furthermore, we show that GPP/SIF can be empirically modeled from climate variables using a machine learning (random forest) framework, which can improve the modeling of ecosystem production and quantify its uncertainty in global terrestrial biosphere models. Our results point to the need for targeted field and experimental studies to better understand the patterns observed and to improve the modeling of the relationship between SIF and GPP over broad scales.

Sensitive quantification of dipicolinic acid from bacterial endospores in soils and sediments - Jayne E. Rattray; Anirban Chakraborty; Carmen Li; Gretta Elizondo; Nisha John; Michelle Wong; Jagoš R. Radović; Thomas B. P. Oldenburg; Casey R. J. Hubert (Environmental Microbiology, 2021)
Summary Endospore‐forming bacteria make up an important and numerically significant component of microbial communities in a range of settings including soils, industry, hospitals and marine sediments extending into the deep subsurface. Bacterial endospores are non‐reproductive structures that protect DNA and improve cell survival during periods unfavourable for bacterial growth. An important determinant of endospores withstanding extreme environmental conditions is 2,6‐pyridine dicarboxylic acid (i.e. dipicolinic acid, or DPA), which contributes heat resistance. This study presents an improved HPLC‐fluorescence method for DPA quantification using a single 10‐min run with pre‐column Tb 3+ chelation. Relative to existing DPA quantification methods, specific improvements pertain to sensitivity, detection limit and range, as well as the development of new free DPA and spore‐specific DPA proxies. The method distinguishes DPA from intact and recently germinated spores, enabling responses to germinants in natural samples or experiments to be assessed in a new way. DPA‐based endospore quantification depends on accurate spore‐specific DPA contents, in particular, thermophilic spores are shown to have a higher DPA content, meaning that marine sediments with plentiful thermophilic spores may require spore number estimates to be revisited. This method has a wide range of potential applications for more accurately quantifying bacterial endospores in diverse environmental samples.

Whole-cell bioreporters for evaluating petroleum hydrocarbon contamination - Bo Jiang; Yizhi Song; Zengjun Liu; Wei E. Huang; Guanghe Li; Songqiang Deng; Yi Xing; Dayi Zhang (Critical Reviews in Environmental Science and Technology, 2021)

Multi-scaling Properties of 2D Reservoir Micro-pore Heterogeneity Based on Digital Casting Thin-Section Images - Lihong Zhou; Mutian Qin; Dunqing Xiao; Chongbiao Leng; Hongjun Li; Shuyun Xie; E. J. M. Carranza; Jinning Zhang (Natural Resources Research, 2021)

Differential Regional Responses in Soluble Monomeric Alpha Synuclein Abundance Following Traumatic Brain Injury - S. W. Carlson; H. Q. Yan; Y. Li; J. Henchir; X. Ma; M. S. Young; M. D. Ikonomovic; C. E. Dixon (Molecular Neurobiology, 2021)

Target region sequencing and applications in plants - Alexandra Ostezan; Samuel Clay McDonald; Dung Thuy Tran; Renan Silva E Souza; Zenglu Li (Journal of Crop Science and Biotechnology, 2021)

High increase in biodegradability of coking wastewater enhanced by Mn ore tailings in Fenton/O3 combined processes - H. Liu; T. Xu; C. Li; W. Liu; E. Lichtfouse (International Journal of Environmental Science and Technology, 2021)

Systematically gap-filling the genome-scale metabolic model of CHO cells - Hamideh Fouladiha; Sayed-Amir Marashi; Shangzhong Li; Zerong Li; Helen O. Masson; Behrouz Vaziri; Nathan E. Lewis (Biotechnology Letters, 2021)

Parasitic begging calls of nestmate-evictor common cuckoos stimulate more parental provisions by red-winged blackbirds than calls of nest-sharing brown-headed cowbirds - Donglai Li; Mark E Hauber (Behavioral Ecology and Sociobiology, 2021)

Plasticity in the grazing ecophysiology of Florenciella (Dichtyochophyceae), a mixotrophic nanoflagellate that consumes Prochlorococcus and other bacteria - Qian Li; Kyle F. Edwards; Christopher R. Schvarcz; Karen E. Selph; Grieg F. Steward (Limnology and Oceanography, 2021)
Mixotrophic nanoflagellates can account for more than half of the bacterivory in the sunlit ocean, yet very little is known about their ecophysiology. Here, we characterize the grazing ecology of an open‐ocean mixotroph in the genus Florenciella (class Dictyochophyceae). Members of this class were indirectly implicated as major consumers of Prochlorococcus and Synechococcus in the oligotrophic North Pacific Subtropical Gyre, but their phagotrophic capabilities have never been investigated. Our studies showed that Florenciella readily consumed Prochlorococcus , Synechococcus , and heterotrophic bacteria, and that the ingested prey relieved nutrient limitations on growth. Florenciella grew faster (3 d −1 ) in nitrogen‐deplete medium given sufficient live Synechococcus , than in nitrogen‐replete K medium (2 d −1 ), but it did not grow in continuous darkness. Grazing rates were substantially higher under nutrient limitation and showed a hint of diel variability, with rates tending to be highest near the end of the light period. An apparent trade‐off between the maximum clearance rate (5 nL Florenciella −1 h −1 ) and the maximum ingestion rate (up to ∼ 10 prey cells Florenciella −1 h −1 ) across experiments suggests that grazing behavior may also vary in response to prey concentration. If the observed grazing rates are representative of other open‐ocean mixotrophs, their collective activity could account for a significant fraction of the daily cyanobacterial mortality. This study provides essential parameters for understanding the grazing ecology of a common marine mixotroph and the first characterization of mixotrophic nanoflagellate functional responses when feeding on unicellular cyanobacteria, the dominant marine primary producers in the oligotrophic ocean.

Large CO 2 release and tidal flushing in salt marsh crab burrows reduce the potential for blue carbon sequestration - Kai Xiao; Alicia M. Wilson; Hailong Li; Isaac R. Santos; Joseph Tamborski; Erik Smith; Susan Q. Lang; Chunmiao Zheng; Xin Luo; Meiqing Lu; Rogger E. Correa (Limnology and Oceanography, 2021)
Abundant crab burrows in carbon‐rich, muddy salt marsh soils act as preferential water flow conduits, potentially enhancing carbon transport across the soil–water interface. With increasing recognition of blue carbon systems (salt marshes, mangroves, and seagrass) as hotspots of soil carbon sequestration, it is important to understand drivers of soil carbon cycling and fluxes. We conducted field observations and flow modeling to assess how crab burrows drive carbon exchange over time scales of minutes to weeks in an intertidal marsh in South Carolina. Results showed that continuous advective porewater exchange between the crab burrows and the surrounding soil matrix occurs because of tidally driven hydraulic gradients. The concentrations of dissolved inorganic (DIC) and organic (DOC) carbon in crab burrow porewater differ with that in the surrounding soil matrix, implying a diffusive C flux in the low‐permeability marsh soil. Gas‐phase concentrations of CO 2 in ∼ 300 crab burrows were approximately six times greater than ambient air. The estimated total C export rate via porewater exchange (1.0 ± 0.7 g C m −2 d −1 ) was much greater than via passive diffusion transport (6.7 ± 2 mg C m −2 d −1 ) and gas‐phase CO 2 release (0.93 mg C m −2 d −1 ). The burrow‐related carbon export was comparable to the regional salt marsh DIC export, groundwater‐derived DIC export, and the net primary production previously estimated using ecosystem‐scale approaches. These insights reveal how crab burrows modify blue carbon sequestration in salt marshes and contribute to coastal carbon budgets.

Knowledge of Cervical Cancer, Human Papilloma Virus (HPV) and HPV Vaccination Among Women in Northeast China - Yu-e Ning; Yao Liu; Xiao-yu Xu; Xin-yu Zhang; Ning Wang; Li-qiang Zheng (Journal of Cancer Education, 2020)
This study aimed to research the understanding and knowledge of cervical cancer, human papilloma virus (HPV), and HPV vaccination, and the acceptance of HPV vaccination, among a population of women in northeastern China. A cross-sectional survey was carried out by questionnaire to investigate knowledge of cervical cancer, HPV, and HPV vaccination. The 230 female participants were native residents of northeastern China, and their ages ranged between 18 and 65 years. Questionnaires were randomly acquired by the respondents from online and paper questionnaire distribution. The questionnaire included questions on three major aspects to record people’s perceptions of cervical cancer, HPV, and vaccines. Of the sample of 230 women surveyed, 80.9% had heard of cervical cancer, but understanding was only 15.7%; 38.3% knew about HPV; 20% knew about HPV vaccine; 39.6% agreed to receive HPV vaccination, and the remainder were mainly concerned about its safety and effectiveness. Data analysis showed that age, family income, and whether there was experience of screening all influenced knowledge of cervical cancer, but this was not statistically significant. The level of education had no obvious effect on the degree of knowledge about cervical cancer; however, with an improvement in education, women’s awareness of HPV vaccine improved significantly ( p < 0.05). Women who have received cervical cancer screening had significantly greater knowledge about cervical cancer and HPV than those with no screening ( p < 0.05). Women in northeastern China have little knowledge of cervical cancer, HPV, and HPV vaccine, lack disease knowledge, and hold a skeptical attitude about HPV vaccination. Medical institutions are the main channel providing information to these women.

The influence on carbon, nitrogen recycling, and greenhouse gas emissions under different C/N ratios by black soldier fly - Wancheng Pang; Dejia Hou; Elhosseny E. Nowar; Huanchun Chen; Jibin Zhang; Guoping Zhang; Qing Li; Shucai Wang (Environmental Science and Pollution Research, 2020)

Reassessing zircon-monazite thermometry with thermodynamic modelling: insights from the Georgetown igneous complex, NE Australia - S. Volante; W. J. Collins; E. Blereau; A. Pourteau; C. Spencer; N. J. Evans; V. Barrote; A. R. Nordsvan; Z.-X. Li; J. Li (Contributions to Mineralogy and Petrology, 2020)
Accessory mineral thermometry and thermodynamic modelling are fundamental tools for constraining petrogenetic models of granite magmatism. U–Pb geochronology on zircon and monazite from S-type granites emplaced within a semi-continuous, whole-crust section in the Georgetown Inlier (GTI), NE Australia, indicates synchronous crystallisation at 1550 Ma. Zircon saturation temperature ( T zr ) and titanium-in-zircon thermometry ( T (Ti–zr) ) estimate magma temperatures of ~ 795 ± 41 °C ( T zr ) and ~ 845 ± 46 °C ( T (Ti-zr) ) in the deep crust, ~ 735 ± 30 °C ( T zr ) and ~ 785 ± 30 °C ( T (Ti-zr) ) in the middle crust, and ~ 796 ± 45 °C ( T zr ) and ~ 850 ± 40 °C ( T (Ti-zr) ) in the upper crust. The differing averages reflect ambient temperature conditions ( T zr ) within the magma chamber, whereas the higher T (Ti-zr) values represent peak conditions of hotter melt injections. Assuming thermal equilibrium through the crust and adiabatic ascent, shallower magmas contained 4 wt% H 2 O, whereas deeper melts contained 7 wt% H 2 O. Using these H 2 O contents, monazite saturation temperature ( T mz ) estimates agree with T zr values. Thermodynamic modelling indicates that plagioclase, garnet and biotite were restitic phases, and that compositional variation in the GTI suites resulted from entrainment of these minerals in silicic (74–76 wt% SiO 2 ) melts. At inferred emplacement P–T conditions of 5 kbar and 730 °C, additional H 2 O is required to produce sufficient melt with compositions similar to the GTI granites. Drier and hotter magmas required additional heat to raise adiabatically to upper-crustal levels. S-type granites are low- T mushes of melt and residual phases that stall and equilibrate in the middle crust, suggesting that discussions on the unreliability of zircon-based thermometers should be modulated.

A global coral reef probability map generated using convolutional neural networks - Jiwei Li; David E. Knapp; Nicholas S. Fabina; Emma V. Kennedy; Kirk Larsen; Mitchell B. Lyons; Nicholas J. Murray; Stuart R. Phinn; Chris M. Roelfsema; Gregory P. Asner (Coral Reefs, 2020)

SNP of AHSA2 gene in three cattle breeds using snapshot technology - Shu-Zhu Cheng; E. Guang-Xin; Cheng-Li Liu; Wang-Dui Basang; Yan-Bin Zhu; Ri-Su Na; Yan-Guo Han; Yan Zeng; Xiao Wang; Wei-Wei Ni; Bai-Gao Yang; Xing-Hai Duan; et al. (Journal of Genetics, 2020)

A Predictive, Two-Parameter Model for the Movement of Reservoir Landslides - Robert E. Criss; Wenmin Yao; Changdong Li; Huiming Tang (Journal of Earth Science, 2020)

2020 taxonomic update for phylum Negarnaviricota (Riboviria: Orthornavirae), including the large orders Bunyavirales and Mononegavirales - Jens H. Kuhn; Scott Adkins; Daniela Alioto; Sergey V. Alkhovsky; Gaya K. Amarasinghe; Simon J. Anthony; Tatjana Avšič-Županc; María A. Ayllón; Justin Bahl; Anne Balkema-Buschmann; Matthew J. Ballinger; Tomáš Bartonička; et al. (Archives of Virology, 2020)

Gravity Measurements along Commercial Ferry Lines in the Baltic Sea and Their Use for Geodetic Purposes - E. Sinem Ince; Christoph Förste; Franz Barthelmes; Hartmut Pflug; Min Li; Jānis Kaminskis; Karl-Hans Neumayer; Grzegorz Michalak (Marine Geodesy, 2020)

Environmentally responsive QTL controlling surface wax load in switchgrass - Jennifer Bragg; Pernell Tomasi; Li Zhang; Tina Williams; Delilah Wood; John T. Lovell; Adam Healey; Jeremy Schmutz; Jason E. Bonnette; Prisca Cheng; Lisa Chanbusarakum; Thomas Juenger; et al. (Theoretical and Applied Genetics, 2020)

Low Static Shear Modulus Along Foliation and Its Influence on the Elastic and Strength Anisotropy of Poorman Schist Rocks, Homestake Mine, South Dakota - Katherine J. Condon; Hiroki Sone; Herbert F. Wang; J. Ajo-Franklin; T. Baumgartner; K. Beckers; D. Blankenship; A. Bonneville; L. Boyd; S. Brown; J. A. Burghardt; C. Chai; et al. (Rock Mechanics and Rock Engineering, 2020)

Correction to: Reassessment of the 1907 Sumatra “Tsunami Earthquake” Based on Macroseismic, Seismological, and Tsunami Observations, and Modeling - Stacey Servito Martin; Linlin Li; Emile A. Okal; Julie Morin; Alexander E. G. Tetteroo; Adam D. Switzer; Kerry E. Sieh (Pure and Applied Geophysics, 2020)

Population pharmacokinetics and dose optimization of ceftriaxone for children with community-acquired pneumonia - Muhammad Wasim Khan; Ya-Kun Wang; Yue-E Wu; Bo-Hao Tang; Min Kan; Hai-Yan Shi; Yi Zheng; Bao-Ping Xu; A-Dong Shen; Evelyne Jacqz-Aigrain; Li-Yuan Tian; Wei Zhao (European Journal of Clinical Pharmacology, 2020)

PSD-93 Interacts with SynGAP and Promotes SynGAP Ubiquitination and Ischemic Brain Injury in Mice - Qingxiu Zhang; Hui Yang; Hong Gao; Xiaomei Liu; Qingjie Li; Rong Rong; Zhenqian Liu; Xiu-e Wei; Liping Kong; Yun Xu; Liangqun Rong (Translational Stroke Research, 2020)

Application of Pharmacokinetic-Pharmacodynamic Modeling to Inform Translation of In Vitro NaV1.7 Inhibition to In Vivo Pharmacological Response in Non-human Primate - Jeanine E. Ballard; Parul Pall; Joshua Vardigan; Fuqiang Zhao; Marie A. Holahan; Richard Kraus; Yuxing Li; Darrell Henze; Andrea Houghton; Christopher S. Burgey; Christopher Gibson (Pharmaceutical Research, 2020)
Purpose This work describes a staged approach to the application of pharmacokinetic-pharmacodynamic (PK-PD) modeling in the voltage-gated sodium ion channel (NaV1.7) inhibitor drug discovery effort to address strategic questions regarding in vitro to in vivo translation of target modulation. Methods PK-PD analysis was applied to data from a functional magnetic resonance imaging (fMRI) technique to non-invasively measure treatment mediated inhibition of olfaction signaling in non-human primates (NHPs). Initial exposure-response was evaluated using single time point data pooled across 27 compounds to inform on in vitro to in vivo correlation (IVIVC). More robust effect compartment PK-PD modeling was conducted for a subset of 10 compounds with additional PD and PK data to characterize hysteresis. Results The pooled compound exposure-response facilitated an early exploration of IVIVC with a limited dataset for each individual compound, and it suggested a 2.4-fold in vitro to in vivo scaling factor for the NaV1.7 target. Accounting for hysteresis with an effect compartment PK-PD model as compounds advanced towards preclinical development provided a more robust determination of in vivo potency values, which resulted in a statistically significant positive IVIVC with a slope of 1.057 ± 0.210, R-squared of 0.7831, and p value of 0.006. Subsequent simulations with the PK-PD model informed the design of anti-nociception efficacy studies in NHPs. Conclusions A staged approach to PK-PD modeling and simulation enabled integration of in vitro NaV1.7 potency, plasma protein binding, and pharmacokinetics to describe the exposure-response profile and inform future study design as the NaV1.7 inhibitor effort progressed through drug discovery.

The Toxicology Investigators Consortium Case Registry—the 2019 Annual Report - Meghan B. Spyres; Lynn A. Farrugia; A. Min Kang; Kim Aldy; Diane P. Calello; Sharan L. Campleman; Shao Li; Gillian A Beauchamp; Timothy Wiegand; Paul M. Wax; Jeffery Brent; P. A. Akpunonu; et al. (Journal of Medical Toxicology, 2020)

Angiotensin (1–7) delivered orally via probiotic, but not subcutaneously, benefits the gut-brain axis in older rats - Thomas W. Buford; Yi Sun; Lisa M. Roberts; Anisha Banerjee; Sujitha Peramsetty; Anthony Knighton; Amrisha Verma; Drake Morgan; Gonzalo E. Torres; Qiuhong Li; Christy S. Carter (GeroScience, 2020)

Reduced regional cerebral venous oxygen saturation is a risk factor for the cognitive impairment in hemodialysis patients: a quantitative susceptibility mapping study - Chao Chai; Huiying Wang; Zhiqiang Chu; Jinping Li; Tianyi Qian; E. Mark Haacke; Shuang Xia; Wen Shen (Brain Imaging and Behavior, 2020)

Seasonal Rainfall Forecasts for the Yangtze River Basin of China in Summer 2019 from an Improved Climate Service - Philip E. Bett; Nicola Martin; Adam A. Scaife; Nick Dunstone; Gill M. Martin; Nicola Golding; Joanne Camp; Peiqun Zhang; Chris D. Hewitt; Leon Hermanson; Chaofan Li; Hong-Li Ren; et al. (Journal of Meteorological Research, 2020)

Noise does not equal bias in assessing the evolutionary history of the angiosperm flora of China: A response to Qian (2019) - Li‐Min Lu; Hai‐Hua Hu; Dan‐Xiao Peng; Bing Liu; Jian‐Fei Ye; Tuo Yang; Hong‐Lei Li; Miao Sun; Stephen A. Smith; Pamela S. Soltis; Douglas E. Soltis; Zhi‐Duan Chen (Journal of Biogeography, 2020)
In response to our paper on the evolutionary history of the Chinese flora, Qian suggests that certain features of the divergence time estimation employed might have led to biased conclusions in Lu et al (2018). Here, we consider Qian's specific criticisms, explore the extent of uncertainty in the data and demonstrate that (i) no systematic bias toward dates that are too young or too old is detected in Lu et al.; (ii) constraint of the crown age of angiosperms does not bias the generic ages estimated by Lu et al.; and (iii) ages derived from the Chinese regional phylogeny do not bias the conclusions reported by Lu et al. All these analyses confirm that the conclusions reported previously are robust. We argue that, like many large‐scale biodiversity analyses, sources of noise in divergence time estimation are to be expected, but these should not be confused with bias.

Identifying areas at risk of drought‐induced tree mortality across South‐Eastern Australia - Martin G. De Kauwe; Belinda E. Medlyn; Anna M. Ukkola; Mengyuan Mu; Manon E. B. Sabot; Andrew J. Pitman; Patrick Meir; Lucas A. Cernusak; Sami W. Rifai; Brendan Choat; David T. Tissue; Chris J. Blackman; et al. (Global Change Biology, 2020)
South‐East Australia has recently been subjected to two of the worst droughts in the historical record (Millennium Drought, 2000–2009 and Big Dry, 2017–2019). Unfortunately, a lack of forest monitoring has made it difficult to determine whether widespread tree mortality has resulted from these droughts. Anecdotal observations suggest the Big Dry may have led to more significant tree mortality than the Millennium drought. Critically, to be able to robustly project future expected climate change effects on Australian vegetation, we need to assess the vulnerability of Australian trees to drought. Here we implemented a model of plant hydraulics into the Community Atmosphere Biosphere Land Exchange (CABLE) land surface model. We parameterized the drought response behaviour of five broad vegetation types, based on a common garden dry‐down experiment with species originating across a rainfall gradient (188–1,125 mm/year) across South‐East Australia. The new hydraulics model significantly improved (~35%–45% reduction in root mean square error) CABLE’s previous predictions of latent heat fluxes during periods of water stress at two eddy covariance sites in Australia. Landscape‐scale predictions of the greatest percentage loss of hydraulic conductivity (PLC) of about 40%–60%, were broadly consistent with satellite estimates of regions of the greatest change in both droughts. In neither drought did CABLE predict that trees would have reached critical PLC in widespread areas (i.e. it projected a low mortality risk), although the model highlighted critical levels near the desert regions of South‐East Australia where few trees live. Overall, our experimentally constrained model results imply significant resilience to drought conferred by hydraulic function, but also highlight critical data and scientific gaps. Our approach presents a promising avenue to integrate experimental data and make regional‐scale predictions of potential drought‐induced hydraulic failure.

Early use of dexamethasone increases Nr4a1 in Kupffer cells ameliorating acute liver failure in mice in a glucocorticoid receptor-dependent manner - Jing-wen Deng; Qin Yang; Xiao-peng Cai; Jia-ming Zhou; Wei-gao E; Yan-dong An; Qiu-xian Zheng; Meng Hong; Yan-li Ren; Jun Guan; Gang Wang; Shu-jing Lai; et al. (Journal of Zhejiang University-SCIENCE B, 2020)

Molecular characterization of gut microbial shift in SD rats after death for 30 days - Huan Li; E. Yang; Siruo Zhang; Jing Zhang; Lu Yuan; Ruina Liu; Shakir Ullah; Qi Wang; Nosheen Mushtaq; Yi Shi; Cuihong An; Zhenyuan Wang; et al. (Archives of Microbiology, 2020)

A bacterial polysaccharide biosynthesis-related gene inversely regulates larval settlement and metamorphosis of Mytilus coruscus - Li-Hua Peng; Xiao Liang; Rui-Heng Chang; Jia-Yi Mu; Hui-E Chen; Asami Yoshida; Kiyoshi Osatomi; Jin-Long Yang (Biofouling, 2020)

10th Anniversary of the European Association for Predictive, Preventive and Personalised (3P) Medicine - EPMA World Congress Supplement 2020 - Olga Golubnitschaja; Ondrej Topolcan; Radek Kucera; Vincenzo Costigliola; M. Akopyan; S. N. Akulov; O Alexandrova; Angel Alonso; Russell J. Andrews; A Assuane Duarte; O. Azarova; Maximilian Babel; et al. (EPMA Journal, 2020)
In 2019, the EPMA celebrated its 10th anniversary at the 5th World Congress in Pilsen, Czech Republic. The history of the International Professional Network dedicated to Predictive, Preventive and Personalised Medicine (PPPM / 3PM) is rich in achievements. Facing the coronavirus COVID-19 pandemic it is getting evident globally that the predictive approach, targeted prevention and personalisation of medical services is the optimal paradigm in healthcare demonstrating the high potential to save lives and to benefit the society as a whole. The EPMA World Congress Supplement 2020 highlights advances in 3P medicine.

Constitutive androstane receptor (CAR) mediates dieldrin-induced liver tumorigenesis in mouse - Zemin Wang; Qiangen Wu; Xilin Li; James E. Klaunig (Archives of Toxicology, 2020)

Population dynamics of threadfin porgy Evynnis cardinalis , an endangered species on the IUCN red list in the Beibu Gulf, South China Sea - Kui Zhang; Yancong Cai; Baochao Liao; Yan'e Jiang; Mingshuai Sun; Li Su; Zuozhi Chen (Journal of Fish Biology, 2020)
Threadfin porgy Evynnis cardinalis is both a dominant fish species and an important fishing target in bottom trawl fisheries in the Beibu Gulf, South China Sea. It was listed as endangered (EN) in a recent International Union for Conservation of Nature (IUCN) red list. Despite its economic importance and endangered status, limited research on its biological characteristics and spatial–temporal distribution has been undertaken this last decade, creating uncertainty in current conservation and management. We analyse this species' spatial distribution characteristics using data from four seasonal bottom trawl surveys in 2014–2015, and report average catch per unit effort to vary seasonally, from 49.1 to 594.5 ind h −1 . Growth, mortality and sexual maturity are reported for four time periods based on data from bottom trawl fishery surveys over 1961–1962, 1998–1999, 2006, and 2014–2015. Length frequency distributions changed from bimodal to unimodal, and the female‐to‐male ratio increased. Mean body length and length at first maturity decreased, whereas the growth coefficient increased, indicating miniaturization, early sexual maturity and accelerated growth, respectively . We report sparid catch to have first exceeded maximum sustainable yield in 2001, and to have remained overfished from 2010 to 2015. Since the 1980s, low‐trophic‐level fishes such as E. cardinalis have replaced high‐trophic‐level fishes such as Crimson snapper Lutjanus erythropterus to become dominant species. As catches have increased substantially, these species have been faced with overfishing, driving the ecosystem into an unstable state.

Causes of slowing‐down seasonal CO 2 amplitude at Mauna Loa - Kai Wang; Yilong Wang; Xuhui Wang; Yue He; Xiangyi Li; Ralph F. Keeling; Philippe Ciais; Martin Heimann; Shushi Peng; Frédéric Chevallier; Pierre Friedlingstein; Stephen Sitch; et al. (Global Change Biology, 2020)
Changing amplitude of the seasonal cycle of atmospheric CO 2 (SCA) in the northern hemisphere is an emerging carbon cycle property. Mauna Loa (MLO) station (20°N, 156°W), which has the longest continuous northern hemisphere CO 2 record, shows an increasing SCA before the 1980s ( p 2 fertilization. This challenges the view that CO 2 fertilization is the dominant cause of emergent SCA trends at northern sites south of 40°N. The contribution of agricultural intensification on the deceleration of SCA at MLO was elusive according to land–atmosphere CO 2 flux estimated by DGVMs and atmospheric inversions. Our results also show the necessity to adequately account for changing circulation patterns in understanding carbon cycle dynamics observed from atmospheric observations and in using these observations to benchmark DGVMs.

Lessening the Hazards of Florida Red Tides: A Common Sense Approach - Porter Hoagland; Barbara Kirkpatrick; Di Jin; Gary Kirkpatrick; Lora E. Fleming; Steven G. Ullmann; Andrew Beet; Gary Hitchcock; Kate K. Harrison; Zongchao C. Li; Bruce Garrison; Roberto E. Diaz; et al. (Frontiers in Marine Science, 2020)

Effect of Chinese Rice Wine on the Endogenous Protease Activity, Myofibrillar Degradation, and Quality Characteristics in Topmouth Culter ( Culter alburnus ) - Fan Wang; Jia-Liang He; Tursunay Turgun; Da-E Ge; Nurgul Rahman; Jian-Zhong Zhou; Xiao-Li Liu (Journal of Aquatic Food Product Technology, 2020)

Retention of Swine Slurry Constituents in Soil and Crop Residue as Affected by Setback Distance - John E. Gilley; Shannon L. Bartelt-Hunt; Kent M. Eskridge; Xu Li; Amy M. Schmidt; Daniel D. Snow (Water, Air, & Soil Pollution, 2020)

Moringa Oleifera Oil Modulates Rumen Microflora to Mediate In Vitro Fermentation Kinetics and Methanogenesis in Total Mix Rations - Hossam M. Ebeid; Li Mengwei; Ahmed E. Kholif; Faiz-ul Hassan; Peng Lijuan; Liang Xin; Yang Chengjian (Current Microbiology, 2020)

Unique microRNA alterations in hepatocellular carcinomas arising either spontaneously or due to chronic exposure to Ginkgo biloba extract (GBE) in B6C3F1/N mice - Haruhiro Yamashita; Sailesh Surapureddi; Ramesh C. Kovi; Sachin Bhusari; Thai Vu Ton; Jian-Liang Li; Keith R. Shockley; Shyamal D. Peddada; Kevin E. Gerrish; Cynthia V. Rider; Mark J. Hoenerhoff; Robert C. Sills; et al. (Archives of Toxicology, 2020)

How pathogens affect the marine habitat use and migration of sea trout ( Salmo trutta ) in two Norwegian fjord systems - Robert J. Lennox; Sindre H. Eldøy; Knut W. Vollset; Kristi M. Miller; Shaorong Li; Karia H. Kaukinen; Trond E. Isaksen; Jan G. Davidsen (Journal of Fish Diseases, 2020)
Wild fish are confronting changing pathogen dynamics arising from anthropogenic disturbance and climate change. Pathogens can influence animal behaviour and life histories, yet there are little such data from fish in the high north where pathogen dynamics may differ from comparatively southern regions. We aimed to compare the pathogen communities of 160 wild anadromous brown trout in two fjords in northern Norway and to determine whether pathogens influenced area use or return to spawn. Application of high‐throughput qPCR detected 11 of the 46 pathogens screened for; most frequently encountered were Ichthyobodo spp., Flavobacterium psychrophilum and Candidatus Branchiomonas cysticola. The rate of returning to freshwater during the spawning season was significantly lower for the Skjerstadfjord fish. Piscichlamydia salmonis and F. psychrophilum were indicator species for the Skjerstadfjord and pathogen communities in the two fjords differed according to perMANOVA. Individual length, Fulton's condition factor and the time between first and last detection of the fish were not related to the presence of pathogens ordinated using non‐metric multidimensional scaling (NMDS). However, there was evidence that pathogen load was correlated with the expression of smoltification genes, which are upregulated by salmonids in freshwater. Correspondingly, percentage of time in freshwater after release was longer for fish with greater pathogen burdens.

RESPONSES OF SOIL WATER‐SALT VARIATION AND COTTON GROWTH TO DRIP IRRIGATION WITH SALINE WATER IN THE LOW PLAIN NEAR THE BOHAI SEA - Anqi Zhang; Chunlian Zheng; Kejiang Li; Hongkai Dang; Caiyun Cao; Abbas E. Rahma; Junpeng Zhang; Di Feng (Irrigation and Drainage, 2020)
To test the feasibility and sustainability of drip irrigation with saline water in the Low Plain near the Bohai Sea (BHLP) in North China, the effects of drip irrigation using saline water on soil water salt, cotton growth, seed cotton yield and fibre quality were conducted during 2017–2018. Five salinity levels of irrigation water were set up: 1.3, 5.4, 8.8, 12.4 and 15.9 dS m‾¹. Cotton evapotranspiration increased first and then decreased with increasing salinity of irrigation water. Soil EC e within the cotton root zone at each stage increased with greater salinity of irrigation water. After a 2‐year experiment soil desalination occurred in the main root layer (top 0–60 cm soil layer) when water salinity was less than 8.8 dS m‾¹. The significant ( p

Comparison of forest above‐ground biomass from dynamic global vegetation models with spatially explicit remotely sensed observation‐based estimates - Hui Yang; Philippe Ciais; Maurizio Santoro; Yuanyuan Huang; Wei Li; Yilong Wang; Ana Bastos; Daniel Goll; Almut Arneth; Peter Anthoni; Vivek K. Arora; Pierre Friedlingstein; et al. (Global Change Biology, 2020)
Gaps in our current understanding and quantification of biomass carbon stocks, particularly in tropics, lead to large uncertainty in future projections of the terrestrial carbon balance. We use the recently published GlobBiomass data set of forest above‐ground biomass (AGB) density for the year 2010, obtained from multiple remote sensing and in situ observations at 100 m spatial resolution to evaluate AGB estimated by nine dynamic global vegetation models (DGVMs). The global total forest AGB of the nine DGVMs is 365 ± 66 Pg C, the spread corresponding to the standard deviation between models, compared to 275 Pg C with an uncertainty of ~13.5% from GlobBiomass. Model‐data discrepancy in total forest AGB can be attributed to their discrepancies in the AGB density and/or forest area. While DGVMs represent the global spatial gradients of AGB density reasonably well, they only have modest ability to reproduce the regional spatial gradients of AGB density at scales below 1000 km. The 95th percentile of AGB density (AGB 95 ) in tropics can be considered as the potential maximum of AGB density which can be reached for a given annual precipitation. GlobBiomass data show local deficits of AGB density compared to the AGB 95 , particularly in transitional and/or wet regions in tropics. We hypothesize that local human disturbances cause more AGB density deficits from GlobBiomass than from DGVMs, which rarely represent human disturbances. We then analyse empirical relationships between AGB density deficits and forest cover changes, population density, burned areas and livestock density. Regression analysis indicated that more than 40% of the spatial variance of AGB density deficits in South America and Africa can be explained; in Southeast Asia, these factors explain only ~25%. This result suggests TRENDY v6 DGVMs tend to underestimate biomass loss from diverse and widespread anthropogenic disturbances, and as a result overestimate turnover time in AGB.

Raman‐activated sorting of antibiotic‐resistant bacteria in human gut microbiota - Yi Wang; Jiabao Xu; Lingchao Kong; Bei Li; Hang Li; Wei E. Huang; Chunmiao Zheng (Environmental Microbiology, 2020)
Summary The antibiotic‐resistant bacteria (ARB) and antibiotic‐resistant genes (ARGs) in human gut microbiota have significant impact on human health. While high throughput metagenomic sequencing reveals genotypes of microbial communities, the functionality, phenotype and heterogeneity of human gut microbiota are still elusive. In this study, we applied Raman microscopy and deuterium isotope probing (Raman–DIP) to detect metabolic active ARB (MA‐ARB) in situ at the single‐cell level in human gut microbiota from two healthy adults. We analysed the relative abundances of MA‐ARB under different concentrations of amoxicillin, cephalexin, tetracycline, florfenicol and vancomycin. To establish the link between phenotypes and genotypes of the MA‐ARB, Raman‐activated cell sorting (RACS) was used to sort MA‐ARB from human gut microbiota, and mini‐metagenomic DNA of the sorted bacteria was amplified, sequenced and analysed. The sorted MA‐ARB and their associated ARGs were identified. Our results suggest a strong relation between ARB in human gut microbiota and personal medical history. This study demonstrates that the toolkit of Raman–DIP, RACS and DNA sequencing can be useful to unravel both phenotypes and genotypes of ARB in human gut microbiota at the single‐cell level.

Early Life Exposure to Environmentally Relevant Levels of Endocrine Disruptors Drive Multigenerational and Transgenerational Epigenetic Changes in a Fish Model - Kaley M. Major; Bethany M. DeCourten; Jie Li; Monica Britton; Matthew L. Settles; Alvine C. Mehinto; Richard E. Connon; Susanne M. Brander (Frontiers in Marine Science, 2020)

Modeling Geometric State for Fluids in Porous Media: Evolution of the Euler Characteristic - James E. McClure; Thomas Ramstad; Zhe Li; Ryan T. Armstrong; Steffen Berg (Transport in Porous Media, 2020)

Small Molecules that Promote Self-Renewal of Stem Cells and Somatic Cell Reprogramming - Guofang Chen; Yu’e Guo; Chao Li; Shuangdi Li; Xiaoping Wan (Stem Cell Reviews and Reports, 2020)

Scutellarin Exerts Anti-Inflammatory Effects in Activated Microglia/Brain Macrophage in Cerebral Ischemia and in Activated BV-2 Microglia Through Regulation of MAPKs Signaling Pathway - Hao-Lun Chen; Wen-Ji Jia; Hong-E Li; Hong Han; Fan Li; Xiao-Li-Na Zhang; Juan-Juan Li; Yun Yuan; Chun-Yun Wu (NeuroMolecular Medicine, 2020)

First Case of Rhinocerebral Mucormycosis Caused by Lichtheimia ornata, with a Review of Lichtheimia Infections - Junling Pan; Clement Tsui; Mengxing Li; Kun Xiao; G. Sybren de Hoog; Paul E. Verweij; Yu Cao; Hongguang Lu; Yanping Jiang (Mycopathologia, 2020)

An easy and robust method for isolation and validation of single-nucleotide polymorphic markers from a first Erysiphe alphitoides draft genome - C. Dutech; N. Feau; I. Lesur; F. Ehrenmann; T. Letellier; B. Li; C. Mouden; E. Guichoux; M.L. Desprez-Loustau; A. Gross (Mycological Progress, 2020)

Microsatellite records for volume 12, issue 2 - In-Chul Bang; Fleur Bruggemann; Chen Chen; Quentin D’Alexis; Hongmei Gao; Pauline Gélin; Xiaoyou Hong; Miho Inoue-Murayama; Kang-Rae Kim; Yeong-Ho Kwak; Wei Li; Haitao Ma; et al. (Conservation Genetics Resources, 2020)

Rainfall manipulation experiments as simulated by terrestrial biosphere models: Where do we stand? - Athanasios Paschalis; Simone Fatichi; Jakob Zscheischler; Philippe Ciais; Michael Bahn; Lena Boysen; Jinfeng Chang; Martin De Kauwe; Marc Estiarte; Daniel Goll; Paul J. Hanson; Anna B. Harper; et al. (Global Change Biology, 2020)
Changes in rainfall amounts and patterns have been observed and are expected to continue in the near future with potentially significant ecological and societal consequences. Modelling vegetation responses to changes in rainfall is thus crucial to project water and carbon cycles in the future. In this study, we present the results of a new model‐data intercomparison project, where we tested the ability of 10 terrestrial biosphere models to reproduce the observed sensitivity of ecosystem productivity to rainfall changes at 10 sites across the globe, in nine of which, rainfall exclusion and/or irrigation experiments had been performed. The key results are as follows: (a) Inter‐model variation is generally large and model agreement varies with timescales. In severely water‐limited sites, models only agree on the interannual variability of evapotranspiration and to a smaller extent on gross primary productivity. In more mesic sites, model agreement for both water and carbon fluxes is typically higher on fine (daily–monthly) timescales and reduces on longer (seasonal–annual) scales. (b) Models on average overestimate the relationship between ecosystem productivity and mean rainfall amounts across sites (in space) and have a low capacity in reproducing the temporal (interannual) sensitivity of vegetation productivity to annual rainfall at a given site, even though observation uncertainty is comparable to inter‐model variability. (c) Most models reproduced the sign of the observed patterns in productivity changes in rainfall manipulation experiments but had a low capacity in reproducing the observed magnitude of productivity changes. Models better reproduced the observed productivity responses due to rainfall exclusion than addition. (d) All models attribute ecosystem productivity changes to the intensity of vegetation stress and peak leaf area, whereas the impact of the change in growing season length is negligible. The relative contribution of the peak leaf area and vegetation stress intensity was highly variable among models.

Sedimentary filling characteristics of the South China Sea oceanic basin, with links to tectonic activity during and after seafloor spreading - Shaoru Yin; Jiabiao Li; Weiwei Ding; Derek E. Sawyer; Ziyin Wu; Yong Tang (International Geology Review, 2020)

Multiscale Study of Physical and Mechanical Properties of Sandstone in Three Gorges Reservoir Region Subjected to Cyclic Wetting–Drying of Yangtze River Water - Wenmin Yao; Changdong Li; Hongbin Zhan; Jia-Qing Zhou; Robert E. Criss; Shuang Xiong; Xihui Jiang (Rock Mechanics and Rock Engineering, 2020)

Medicago truncatula adjusts root proliferation, nodule formation, and partner choice in response to local N heterogeneity - Xuechun Zhang; Lucian Wang; Judith Li; Rebecca T. Batstone; Megan E. Frederickson (Plant and Soil, 2020)

Preparation, characterization, and antifungal evaluation of a new type of aminourea chitooligosaccharide derivatives - Jun Zhu; Song Liu; Yukun Qin; Rong’e Xing; Huahua Yu; Xiaolin Chen; Pengcheng Li (Journal of Oceanology and Limnology, 2020)

PI3K/Akt pathway is involved in the activation of RAW 264.7 cells induced by hydroxypropyltrimethyl ammonium chloride chitosan - Yue Yang; Rong’e Xing; Song Liu; Yukun Qin; Kecheng Li; Huahua Yu; Pengcheng Li (Journal of Oceanology and Limnology, 2020)

Mitogenomic phylogeny of the Naticidae (Gastropoda: Littorinimorpha) reveals monophyly of the Polinicinae - Hongyue Liu; Yi Yang; Shao'e Sun; Lingfeng Kong; Qi Li (Zoologica Scripta, 2020)
The Naticidae is a species‐rich family of predatory marine gastropods with substantial interspecific morphological diversity. The classification of the Naticidae has been traditionally based on morphology data, but the phylogenetic relationships within the family are debated due to conflicting molecular results, especially regarding the monophyly of subfamilies Polinicinae and Naticinae. To further resolve the phylogenetic controversies within the Naticidae, we undertake a phylogenetic approach using 14 newly sequenced complete or nearly complete (only lacking a control region) mitochondrial genomes. Both the maximum likelihood and Bayesian inference analyses supported monophyly of the Polinicinae, but paraphyly of the Naticinae due to the placement of the enigmatic genus Notocochlis . The ancestral character reconstruction suggests that the operculum, a character that currently defines the two subfamilies, evolved from an ancestor with a calcareous operculum in the evolutionary history of naticids. In addition, the chronogram estimates that naticids was originated in late Triassic (about 227 million years ago), consistent with previous hypotheses. Our study highlights the importance of using complete mitochondrial genomes while reconstructing phylogenetic relationships within the Naticidae. The evolution scenario of the naticid operculum contributes new insights into the classification of Naticidae.

Quantifying irrigation cooling benefits to maize yield in the US Midwest - Yan Li; Kaiyu Guan; Bin Peng; Trenton E. Franz; Brian Wardlow; Ming Pan (Global Change Biology, 2020)
Irrigation is an important adaptation strategy to improve crop resilience to global climate change. Irrigation plays an essential role in sustaining crop production in water‐limited regions, as irrigation water not only benefits crops through fulfilling crops' water demand but also creates an evaporative cooling that mitigates crop heat stress. Here we use satellite remote sensing and maize yield data in the state of Nebraska, USA, combined with statistical models, to quantify the contribution of cooling and water supply to the yield benefits due to irrigation. Results show that irrigation leads to a considerable cooling on daytime land surface temperature (−1.63°C in July), an increase in enhanced vegetation index (+0.10 in July), and 81% higher maize yields compared to rainfed maize. These irrigation effects vary along the spatial and temporal gradients of precipitation and temperature, with a greater effect in dry and hot conditions, and decline toward wet and cool conditions. We find that 16% of irrigation yield increase is due to irrigation cooling, while the rest (84%) is due to water supply and other factors. The irrigation cooling effect is also observed on air temperature (−0.38 to −0.53°C) from paired flux sites in Nebraska. This study highlights the non‐negligible contribution of irrigation cooling to the yield benefits of irrigation, and such an effect may become more important in the future with continued warming and more frequent droughts.

Microbial communities from Arctic marine sediments respond slowly to methane addition during ex situ enrichments - Scott Klasek; Marta E. Torres; Douglas H. Bartlett; Madeline Tyler; Wei‐Li Hong; Frederick Colwell (Environmental Microbiology, 2020)
Summary Anaerobic methanotrophic archaea (ANME) consume methane in marine sediments, limiting its release to the water column, but their responses to changes in methane and sulfate supplies remain poorly constrained. To address how methane exposure may affect microbial communities and methane‐ and sulfur‐cycling gene abundances in Arctic marine sediments, we collected sediments from offshore Svalbard that represent geochemical horizons where anaerobic methanotrophy is expected to be active, previously active, and long‐inactive based on reaction‐transport biogeochemical modelling of porewater sulfate profiles. Sediment slurries were incubated at in situ temperature and pressure with different added methane concentrations. Sediments from an active area of seepage began to reduce sulfate in a methane‐dependent manner within months, preceding increased relative abundances of anaerobic methanotrophs ANME‐1 within communities. In previously active and long‐inactive sediments, sulfur‐cycling Deltaproteobacteria became more dominant after 30 days, though these communities showed no evidence of methanotrophy after nearly 8 months of enrichment. Overall, enrichment conditions, but not methane, broadly altered microbial community structure across different enrichment times and sediment types. These results suggest that active ANME populations may require years to develop, and consequently microbial community composition may affect methanotrophic responses to potential large‐scale seafloor methane releases in ways that provide insight for future modelling studies.

Taxonomic revision, phylogeny, and cyst wall composition of the dinoflagellate cyst genus Votadinium Reid (Dinophyceae, Peridiniales, Protoperidiniaceae) - Pieter R. Gurdebeke; Kenneth N. Mertens; Vera Pospelova; Kazumi Matsuoka; Zhen Li; Kristin E. Gribble; Haifeng Gu; Kara Bogus; Henk Vrielinck; Stephen Louwye (Palynology, 2020)

Cytoplasmic Autoinhibition in HCN Channels is Regulated by the Transmembrane Region - Dana A. Page; Kaylee E. A. Magee; Jessica Li; Matthew Jung; Edgar C. Young (The Journal of Membrane Biology, 2020)
Hyperpolarization-activated cation-nonselective (HCN) channels regulate electrical activity in the brain and heart in a cAMP-dependent manner. The voltage-gating of these channels is mediated by a transmembrane (TM) region but is additionally regulated by direct binding of cAMP to a cyclic nucleotide-binding (CNB) fold in the cytoplasmic C-terminal region. Cyclic AMP potentiation has been explained by an autoinhibition model which views the unliganded CNB fold as an inhibitory module whose influence is disrupted by cAMP binding. However, the HCN2 subtype uses two other CNB fold-mediated mechanisms called open-state trapping and Quick-Activation to respectively slow the deactivation kinetics and speed the activation kinetics, against predictions of an autoinhibition model. To test how these multiple mechanisms are influenced by the TM region, we replaced the TM region of HCN2 with that of HCN4. This HCN4 TM-replacement preserved cAMP potentiation but augmented the magnitude of autoinhibition by the unliganded CNB fold; it moreover disrupted open-state trapping and Quick-Activation so that autoinhibition became the dominant mechanism contributed by the C-terminal region to determine kinetics. Truncation within the CNB fold partially relieved this augmented autoinhibition. This argues against the C-terminal region acting like a portable module with consistent effects on TM regions of different subtypes. Our findings provide evidence that functional interactions between the HCN2 TM region and C-terminal region govern multiple CNB fold-mediated mechanisms, implying that the molecular mechanisms of autoinhibition, open-state trapping, and Quick-Activation include participation of TM region structures.

Cochlear protein biomarkers as potential sites for targeted inner ear drug delivery - James G. Naples; Lauren E. Miller; Andrew Ramsey; Daqing Li (Drug Delivery and Translational Research, 2020)
The delivery of therapies to the cochlea is notoriously challenging. It is an organ protected by a number of barriers that need to be overcome in the drug delivery process. Additionally, there are multiple sites of possible damage within the cochlea. Despite the many potential sites of damage, acquired otologic insults preferentially damage a single location. While progress has been made in techniques for inner ear drug delivery, the current techniques remain non-specific and our ability to deliver therapies in a cell-specific manner are limited. Fortunately, there are proteins specific to various cell-types within the cochlea (e.g., hair cells, spiral ganglion cells, stria vascularis) that function as biomarkers of site-specific damage. These protein biomarkers have potential to serve as targets for cell-specific inner ear drug delivery. In this manuscript, we review the concept of biomarkers and targeted- inner ear drug delivery and the well-characterized protein biomarkers within each of the locations of interest within the cochlea. Our review will focus on targeted drug delivery in the setting of acquired otologic insults (e.g., ototoxicity, noise-induce hearing loss). The goal is not to discuss therapies to treat acquired otologic insults, rather, to establish potential concepts of how to deliver therapies in a targeted, cell-specific manner. Based on our review, it is clear that future of inner ear drug delivery is a discipline filled with potential that will require collaborative efforts among clinicians and scientists to optimize treatment of otologic insults.

Study of the closure temperature of (U-Th)/He in detrital zircon obtained from natural evolution samples - Chang’e Cai; Nansheng Qiu; Huili Li; Daniel F. Stockli; Jian Chang; Nian Liu (Science China Earth Sciences, 2020)

Reduced growth responses of mesosulfuron-methyl-resistant blackgrass to allelopathic wheat are driven by underground chemical interaction - Xuefang Yang; Yingying He; Xi’E Song; Xiangyang Yuan; Yongfeng Li; Dasheng Sun (Plant and Soil, 2020)

Retraction Note: Aluminum in Neurological and Neurodegenerative Disease - Donald R. C. McLachlan; Catherine Bergeron; Peter N. Alexandrov; William J. Walsh; Aileen I. Pogue; Maire E. Percy; Theodore P. A. Kruck; Zhide Fang; Nathan M. Sharfman; Vivian Jaber; Yuhai Zhao; Wenhong Li; et al. (Molecular Neurobiology, 2020)

Safety, pharmacokinetic and pharmacodynamic properties of single ascending dose and continuous infusion of remimazolam besylate in healthy Chinese volunteers - Xiao-yan Sheng; Yan Liang; Xue-yuan Yang; Li-e Li; Xia Ye; Xia Zhao; Yi-min Cui (European Journal of Clinical Pharmacology, 2020)

Arsenic Distribution, Accumulation and Tolerance Mechanisms of Typha angustifolia in Different Phenological Growth Stages - Guiying Yang; Huan Zhong; Xue Liu; Chang’e Liu; Shiyu Li; Lei Hou; Yungen Liu; Yan Wang; Wei Ren; Changqun Duan (Bulletin of Environmental Contamination and Toxicology, 2020)

Population-based meta-analysis of bortezomib exposure–response relationships in multiple myeloma patients - Li Zhang; Donald E. Mager (Journal of Pharmacokinetics and Pharmacodynamics, 2020)

Analysis of an Ensemble of High-Resolution WRF Simulations for the Rapid Intensification of Super Typhoon Rammasun (2014) - Xun Li; Noel E. Davidson; Yihong Duan; Kevin J. Tory; Zhian Sun; Qinbo Cai (Advances in Atmospheric Sciences, 2020)

Returning Degraded Soils to Productivity: an Examination of the Potential of Coarse Woody Amendments for Improved Water Retention and Nutrient Holding Capacity - E. G. Menzies Pluer; R.L. Schneider; S.J. Morreale; M.A. Liebig; J. Li; C.X. Li; M.T. Walter (Water, Air, & Soil Pollution, 2020)

Carbon and nitrogen mineralization differ between incorporated shoots and roots of legume versus non-legume based cover crops - Fucui Li; Peter Sørensen; Xiaoxi Li; Jørgen E. Olesen (Plant and Soil, 2020)

Atmospheric mercury accumulation rate in northeastern China during the past 800 years as recorded by the sediments of Tianchi Crater Lake - Tao Zhan; Xin Zhou; Wenhan Cheng; Xiaoqing He; Luyao Tu; Xiaoyan Liu; Junyi Ge; Yuanyun Xie; Jun Zhang; Yongfa Ma; E Li; Yansong Qiao (Environmental Science and Pollution Research, 2020)

The global Microcystis interactome - Katherine V. Cook; Chuang Li; Haiyuan Cai; Lee R. Krumholz; K. David Hambright; Hans W. Paerl; Morgan M. Steffen; Alan E. Wilson; Michele A. Burford; Hans‐Peter Grossart; David P. Hamilton; Helong Jiang; et al. (Limnology and Oceanography, 2020)
Bacteria play key roles in the function and diversity of aquatic systems, but aside from study of specific bloom systems, little is known about the diversity or biogeography of bacteria associated with harmful cyanobacterial blooms (cyanoHABs). CyanoHAB species are known to shape bacterial community composition and to rely on functions provided by the associated bacteria, leading to the hypothesized cyanoHAB interactome, a coevolved community of synergistic and interacting bacteria species, each necessary for the success of the others. Here, we surveyed the microbiome associated with Microcystis aeruginosa during blooms in 12 lakes spanning four continents as an initial test of the hypothesized Microcystis interactome. We predicted that microbiome composition and functional potential would be similar across blooms globally. Our results, as revealed by 16S rRNA sequence similarity, indicate that M. aeruginosa is cosmopolitan in lakes across a 280° longitudinal and 90° latitudinal gradient. The microbiome communities were represented by a wide range of operational taxonomic units and relative abundances. Highly abundant taxa were more related and shared across most sites and did not vary with geographic distance, thus, like Microcystis , revealing no evidence for dispersal limitation. High phylogenetic relatedness, both within and across lakes, indicates that microbiome bacteria with similar functional potential were associated with all blooms. While Microcystis and the microbiome bacteria shared many genes, whole‐community metagenomic analysis revealed a suite of biochemical pathways that could be considered complementary. Our results demonstrate a high degree of similarity across global Microcystis blooms, thereby providing initial support for the hypothesized Microcystis interactome.

Methane production in the oxygenated water column of a perennially ice‐covered Antarctic lake - Wei Li; John E. Dore; August J. Steigmeyer; Yong‐Joon Cho; Ok‐Sun Kim; Yongqin Liu; Rachael M. Morgan‐Kiss; Mark L. Skidmore; John C. Priscu (Limnology and Oceanography, 2020)
Aerobic methane production in aquatic ecosystems impacts the global atmospheric budget of methane, but the extent, mechanism, and taxa responsible for producing this greenhouse gas are not fully understood. Lake Bonney (LB), a perennially ice‐covered Antarctic lake, has cold hypersaline waters underlying an oxygenated freshwater layer. We present temporal methane concentration profiles in LB indicating methane production in the oxygenated (> 200% air saturation) water. Experiments amended with methylphosphonate (MPn) yielded methane generation, suggesting in situ methanogenesis via the carbon‐phosphorus (C‐P) lyase pathway. Enrichment cultures from the lake were used to isolate five bacterial strains capable of generating methane when supplied with MPn as the sole P source. Based on 16S rRNA gene sequencing, the isolates belong to the Proteobacteria (closely related to Marinomonas , Hoeflea , and Marinobacter genera) and Bacteroidetes ( Algoriphagus genus). 16S rRNA metagenomic sequencing confirms the presence of these taxa in LB. None of the isolated species were reported to be capable to produce methane. In addition, orthologs of the phosphoenolpyruvate mutase gene ( PepM ) and methylphosphonate synthase ( MPnS ), enzymes involved in phosphonate and MPn biosynthesis, were widely spread in the LB shotgun metagenomic libraries; genes related to C‐P lyase pathways ( phn gene clusters) were also abundant. 16S rRNA and mcrA genes of anaerobic methanogens were absent in both 16S rRNA and metagenomics libraries. These data reveal that in situ aerobic biological methane production is likely a significant source of methane in LB.

Nonlinear responses of soil nematode community composition to increasing aridity - Dan Xiong; CunZheng Wei; E. R. Jasper Wubs; G. F. Veen; Wenju Liang; Xiaobo Wang; Qi Li; Wim H. Van der Putten; Xingguo Han (Global Ecology and Biogeography, 2020)
Aim Increasing aridity under global change is predicted to have a profound impact on the structure and functioning of terrestrial ecosystems, yet we have a poor understanding of how belowground communities respond. In order to understand the longer term responses of different trophic levels in the soil food web to increasing aridity, we investigated the abundance, richness and community similarity of the soil nematode community along a 3,200 km aridity gradient. Location A transect across semi‐arid and arid grasslands in Northern China, where the aridity ranges from .43 to .97. Time period July and August 2012. Major taxa studied Soil‐borne Nematoda. Methods We used generalized additive (mixed) models to analyse the abundance, richness and community similarity patterns of soil nematodes. We used structural equation modelling (SEM) to disentangle the direct and indirect environmental drivers (aridity, soil and plant variables) of the nematode community. Results The abundance, richness and similarity of nematode communities declined nonlinearly with increasing aridity. The most pronounced decline in nematode richness and community similarity occurred in arid conditions (aridity > .80). However, the shape of the response to aridity differed among nematode feeding groups. In arid conditions, the abundance and richness of bacterial feeders were less sensitive to changes in aridity than for fungal feeders. The SEM analysis revealed that nematode community responses to aridity were not mediated via changes in plant and soil variables, but instead were affected directly by aridity. Main conclusions Our results showed that in mesic grasslands, increasing aridity primarily caused a decline in nematode abundance, whereas increasing aridity in xeric grasslands led to a loss of nematode diversity. The nonlinear responses of nematodes to aridity could also result in nonlinear shifts in ecosystem functioning, because soil nematodes operate at various trophic levels in the soil food web, thereby influencing the performance of plants, soil biodiversity and biogeochemical cycling.

TRY plant trait database – enhanced coverage and open access - Jens Kattge; Gerhard Bönisch; Sandra Díaz; Sandra Lavorel; Iain Colin Prentice; Paul Leadley; Susanne Tautenhahn; Gijsbert D. A. Werner; Tuomas Aakala; Mehdi Abedi; Alicia T. R. Acosta; George C. Adamidis; et al. (Global Change Biology, 2020)
Plant traits—the morphological, anatomical, physiological, biochemical and phenological characteristics of plants—determine how plants respond to environmental factors, affect other trophic levels, and influence ecosystem properties and their benefits and detriments to people. Plant trait data thus represent the basis for a vast area of research spanning from evolutionary biology, community and functional ecology, to biodiversity conservation, ecosystem and landscape management, restoration, biogeography and earth system modelling. Since its foundation in 2007, the TRY database of plant traits has grown continuously. It now provides unprecedented data coverage under an open access data policy and is the main plant trait database used by the research community worldwide. Increasingly, the TRY database also supports new frontiers of trait‐based plant research, including the identification of data gaps and the subsequent mobilization or measurement of new data. To support this development, in this article we evaluate the extent of the trait data compiled in TRY and analyse emerging patterns of data coverage and representativeness. Best species coverage is achieved for categorical traits—almost complete coverage for ‘plant growth form’. However, most traits relevant for ecology and vegetation modelling are characterized by continuous intraspecific variation and trait–environmental relationships. These traits have to be measured on individual plants in their respective environment. Despite unprecedented data coverage, we observe a humbling lack of completeness and representativeness of these continuous traits in many aspects. We, therefore, conclude that reducing data gaps and biases in the TRY database remains a key challenge and requires a coordinated approach to data mobilization and trait measurements. This can only be achieved in collaboration with other initiatives.

One bis-indole alkaloid-voacamine from Voacanga africana Stapf: biological activity evaluation of PTP1B in vitro utilizing enzymology method based on SPRi expriment - Yan-Qiu Wang; Hong-Xiang Li; Xiao-Chun Liu; Jin-Shuang Zhao; Rong-Qiang Liu; Wen-ying Huai; Wei-Jun Ding; Tian-E Zhang; Yun Deng (Natural Product Research, 2019)

Correction to: Recombination between homoeologous chromosomes induced in durum wheat by the Aegilops speltoides Su1-Ph1 suppressor - Hao Li; Le Wang; Ming-Cheng Luo; Fang Nie; Yun Zhou; Patrick E. McGuire; Assaf Distelfeld; Xiongtao Dai; Chun-Peng Song; Jan Dvorak (Theoretical and Applied Genetics, 2019)

Recombination between homoeologous chromosomes induced in durum wheat by the Aegilops speltoides Su1-Ph1 suppressor - Hao Li; Le Wang; Ming-Cheng Luo; Fang Nie; Yun Zhou; Patrick E. McGuire; Assaf Distelfeld; Xiongtao Dai; Chun-Peng Song; Jan Dvorak (Theoretical and Applied Genetics, 2019)

Effects of Modifiers on the Growth, Photosynthesis, and Antioxidant Enzymes of Cotton Under Cadmium Toxicity - MengJie An; HaiJiang Wang; Hua Fan; J. A. Ippolito; Chunmei Meng; Yulian E.; Yingbin Li; Kaiyong Wang; Changzhou Wei (Journal of Plant Growth Regulation, 2019)

A prospective comparative study of children with gastroenteritis: emergency department compared with symptomatic care at home - Otto G. Vanderkooi; Jianling Xie; Bonita E. Lee; Xiao-Li Pang; Linda Chui; Daniel C. Payne; Judy MacDonald; Samina Ali; Shannon MacDonald; Steve Drews; Lara Osterreicher; Kelly Kim; et al. (European Journal of Clinical Microbiology & Infectious Diseases, 2019)

Tropical cyclone damages in Mainland China over 2005–2016: losses analysis and implications - Hong Wang; Min Xu; Anselem Onyejuruwa; Yanjun Wang; Shanshan Wen; Andrew E. Gao; Yubin Li (Environment, Development and Sustainability, 2019)

Distinctiveness, speciation and demographic history of the rare endemic conifer Juniperus erectopatens in the eastern Qinghai-Tibet Plateau - Jingjing Xu; Xinya Song; Markus Ruhsam; Tingxuan Liu; Jialiang Li; Linda E. Neaves; Jibin Miao; Siyu Xie; Qingyu Meng; Kangshan Mao (Conservation Genetics, 2019)

Microbial Transformation of A Sulfonamide Antibiotic Under Various Background Nutrient Conditions - Rachel E. Levine; Yuping Zhang; Yifei Leng; Daniel D. Snow; David Cassada; Lisa M. Durso; Xu Li (Bulletin of Environmental Contamination and Toxicology, 2019)

Association Between Cystatin C and the Risk of Ischemic Stroke: a Systematic Review and Meta-analysis - Yan Wang; Wei Li; Jun Yang; Mijuan Zhang; Chun’e Tian; Minjiang Ma; Qian Zhang (Journal of Molecular Neuroscience, 2019)

Identification of a novel locus, BPH38(t), conferring resistance to brown planthopper (Nilaparvata lugens Stal.) using early backcross population in rice (Oryza sativa L.) - C. H. Balachiranjeevi; G. D. Prahalada; A. Mahender; Md. Jamaloddin; M. A. L. Sevilla; C. M. Marfori-Nazarea; R. Vinarao; U. Sushanto; S. E. Baehaki; Z. K. Li; J. Ali (Euphytica, 2019)
Rice is the most important staple food crop, and it feeds more than half of the world population. Brown planthopper (BPH) is a major insect pest of rice that causes 20–80% yield loss through direct and indirect damage. The identification and use of BPH resistance genes can efficiently manage BPH. A molecular marker-based genetic analysis of BPH resistance was carried out using 101 BC 1 F 5 mapping population derived from a cross between a BPH-resistant indica variety Khazar and an elite BPH-susceptible line Huang–Huan–Zhan. The genetic analysis indicated the existence of Mendelian segregation for BPH resistance. A total of 702 high-quality polymorphic single nucleotide polymorphism (SNP) markers, genotypic data, and precisely estimated BPH scores were used for molecular mapping, which resulted in the identification of the BPH38 (t) locus on the long arm of chromosome 1 between SNP markers 693,369 and id 10,112,165 of 496.2 kb in size with LOD of 20.53 and phenotypic variation explained of 35.91%. A total of 71 candidate genes were predicted in the detected locus. Among these candidate genes, LOC_Os01g37260 was found to belong to the FBXL class of F-box protein possessing the LRR domain, which is reported to be involved in biotic stress resistance. Furthermore, background analysis and phenotypic selection resulted in the identification of introgression lines (ILs) possessing at least 90% recurrent parent genome recovery and showing superior performance for several agro-morphological traits. The BPH resistance locus and ILs identified in the present study will be useful in marker-assisted BPH resistance breeding programs.

Heat shock protein 70 is a key molecule to rescue imbalance caused by low-frequency noise - Reina Negishi-Oshino; Nobutaka Ohgami; Tingchao He; Xiang Li; Masashi Kato; Masayoshi Kobayashi; Yishuo Gu; Kanako Komuro; Charalampos E. Angelidis; Masashi Kato (Archives of Toxicology, 2019)

The effect of substrate grain size on burrowing ability and distribution characteristics of Perinereis aibuhitensis - Tao Sun; Chun’e Liu; Xingzuo Li; Dongzhengyang An; Hairui Yu; Zheng Ma; Feng Liu (Acta Oceanologica Sinica, 2019)

Cryptic phenology in plants: Case studies, implications, and recommendations - Loren P. Albert; Natalia Restrepo‐Coupe; Marielle N. Smith; Jin Wu; Cecilia Chavana‐Bryant; Neill Prohaska; Tyeen C. Taylor; Giordane A. Martins; Philippe Ciais; Jiafu Mao; M. Altaf Arain; Wei Li; et al. (Global Change Biology, 2019)
Plant phenology—the timing of cyclic or recurrent biological events in plants—offers insight into the ecology, evolution, and seasonality of plant‐mediated ecosystem processes. Traditionally studied phenologies are readily apparent, such as flowering events, germination timing, and season‐initiating budbreak. However, a broad range of phenologies that are fundamental to the ecology and evolution of plants, and to global biogeochemical cycles and climate change predictions, have been neglected because they are “cryptic”—that is, hidden from view (e.g., root production) or difficult to distinguish and interpret based on common measurements at typical scales of examination (e.g., leaf turnover in evergreen forests). We illustrate how capturing cryptic phenology can advance scientific understanding with two case studies: wood phenology in a deciduous forest of the northeastern USA and leaf phenology in tropical evergreen forests of Amazonia. Drawing on these case studies and other literature, we argue that conceptualizing and characterizing cryptic plant phenology is needed for understanding and accurate prediction at many scales from organisms to ecosystems. We recommend avenues of empirical and modeling research to accelerate discovery of cryptic phenological patterns, to understand their causes and consequences, and to represent these processes in terrestrial biosphere models.

Supporting Spartina : Interdisciplinary perspective shows Spartina as a distinct solid genus - Alejandro Bortolus; Paul Adam; Janine B. Adams; Malika L. Ainouche; Debra Ayres; Mark D. Bertness; Tjeerd J. Bouma; John F. Bruno; Isabel Caçador; James T. Carlton; Jesus M. Castillo; Cesar S. B. Costa; et al. (Ecology, 2019)
In 2014, a DNA‐based phylogenetic study confirming the paraphyly of the grass subtribe Sporobolinae proposed the creation of a large monophyletic genus Sporobolus , including (among others) species previously included in the genera Spartina , Calamovilfa , and Sporobolus. Spartina species have contributed substantially (and continue contributing) to our knowledge in multiple disciplines, including ecology, evolutionary biology, molecular biology, biogeography, experimental ecology, biological invasions, environmental management, restoration ecology, history, economics, and sociology. There is no rationale so compelling to subsume the name Spartina as a subgenus that could rival the striking, global iconic history and use of the name Spartina for over 200 yr. We do not agree with the subjective arguments underlying the proposal to change Spartina to Sporobolus . We understand the importance of both the objective phylogenetic insights and of the subjective formalized nomenclature and hope that by opening this debate we will encourage positive feedback that will strengthen taxonomic decisions with an interdisciplinary perspective. We consider that the strongly distinct, monophyletic clade Spartina should simply and efficiently be treated as the genus Spartina .

Skilful seasonal prediction of winter wind speeds in China - Julia F. Lockwood; Hazel E. Thornton; Nick Dunstone; Adam A. Scaife; Philip E. Bett; Chaofan Li; Hong-Li Ren (Climate Dynamics, 2019)

The conserved CDC motif in the yeast iron regulator Aft2 mediates iron–sulfur cluster exchange and protein–protein interactions with Grx3 and Bol2 - Haoran Li; Caryn E. Outten (JBIC Journal of Biological Inorganic Chemistry, 2019)

Effect of pyrolysis condition on the adsorption mechanism of heavy metals on tobacco stem biochar in competitive mode - Nan Zhou; Junning Zu; Qiuju Feng; Huanli Chen; Juan Li; Mei-e Zhong; Zhi Zhou; Shuxin Zhuang (Environmental Science and Pollution Research, 2019)

Diversification of mitogenomes in three sympatric Altica flea beetles (Insecta, Chrysomelidae) - Rui‐E Nie; Jing Wei; Shou‐Ke Zhang; Alfried P. Vogler; Ling Wu; Alexander S. Konstantinov; Wen‐Zhu Li; Xing‐Ke Yang; Huai‐Jun Xue (Zoologica Scripta, 2019)
The Asian flea beetles Altica cirsicola , Altica fragariae and Altica viridicyanea are broadly sympatric and morphologically highly similar but feed on distantly related host plants. They have been suggested as a model for ecological speciation studies. However, their phylogeny and species limits remain uncertain. In this study, we added mitochondrial genomes from multiple individuals of each species to the growing database. Phylogenetic analyses based on 15 genes showed clear interspecific divergences of A. fragariae from the other species, but A. cirsicola and A. viridicyanea were not distinguishable by distance‐based or tree‐based methods of species delimitation due to non‐monophyly of mitogenomes relative to the morphologically defined entities, possibly affected by interspecific introgression. This was confirmed by wider sampling of mitochondrial COX1 (58 individuals) and the second internal transcribed spacer of nuclear ribosomal RNA cluster (ITS2; 68 individuals), which showed that ITS2, but not COX1, coincided with the morphological species limits. The full mitochondrial genomes are not able to shed further light on the species status, even with the most sensitive approach based on diagnostic characters, yet the whole mitogenome is useful to get improved estimates of intra‐ and interspecific variation, not affected by the stochastic error seen in individual genes.

It’s about time: A synthesis of changing phenology in the Gulf of Maine ecosystem - Michelle D. Staudinger; Katherine E. Mills; Karen Stamieszkin; Nicholas R. Record; Christine A. Hudak; Andrew Allyn; Antony Diamond; Kevin D. Friedland; Walt Golet; Meghan Elisabeth Henderson; Christina M. Hernandez; Thomas G. Huntington; et al. (Fisheries Oceanography, 2019)
The timing of recurring biological and seasonal environmental events is changing on a global scale relative to temperature and other climate drivers. This study considers the Gulf of Maine ecosystem, a region of high social and ecological importance in the Northwest Atlantic Ocean and synthesizes current knowledge of (a) key seasonal processes, patterns, and events; (b) direct evidence for shifts in timing; (c) implications of phenological responses for linked ecological‐human systems; and (d) potential phenology‐focused adaptation strategies and actions. Twenty studies demonstrated shifts in timing of regional marine organisms and seasonal environmental events. The most common response was earlier timing, observed in spring onset, spring and winter hydrology, zooplankton abundance, occurrence of several larval fishes, and diadromous fish migrations. Later timing was documented for fall onset, reproduction and fledging in Atlantic puffins, spring and fall phytoplankton blooms, and occurrence of additional larval fishes. Changes in event duration generally increased and were detected in zooplankton peak abundance, early life history periods of macro‐invertebrates, and lobster fishery landings. Reduced duration was observed in winter–spring ice‐affected stream flows. Two studies projected phenological changes, both finding diapause duration would decrease in zooplankton under future climate scenarios. Phenological responses were species‐specific and varied depending on the environmental driver, spatial, and temporal scales evaluated. Overall, a wide range of baseline phenology and relevant modeling studies exist, yet surprisingly few document long‐term shifts. Results reveal a need for increased emphasis on phenological shifts in the Gulf of Maine and identify opportunities for future research and consideration of phenological changes in adaptation efforts.

Biogeographic freshwater fish pattern legacy revealed despite rapid socio‐economic changes in China - Chuanbo Guo; Yushun Chen; Rodolphe E. Gozlan; Zhongjie Li; Thomas Mehner; Sovan Lek; Craig P. Paukert (Fish and Fisheries, 2019)
Understanding drivers of freshwater fish assemblages is critically important for biodiversity conservation strategies, especially in rapidly developing countries, which often have environmental protections lagging behind economic development. The influences of natural and human factors in structuring fish assemblages and their relative contributions are likely to change given the increasing magnitude of human activities. To discriminate natural and human drivers of fish diversity and assemblage patterns in developing countries with rapid socio‐economic development, a dataset of 908 freshwater fish species and 13 metrics including three categories of both natural (i.e., biogeographic) and human drivers (i.e., economic growth, inland fisheries) in China were analysed with machine learning algorithms (i.e., self‐organizing map, random forest). Here, we found that biogeographic drivers explained 21.8% of the observed fish assemblage patterns in China and remained stronger predictors when compared to human drivers (i.e., 15.6%, respectively). Freshwater fish species richness was positively correlated to rainfall, air temperature, surface water area and inland fisheries production but negatively correlated with urbanization. In addition, the strong structuring effects of climatic variables on Chinese fish richness patterns suggested that the fish assemblages could be particularly vulnerable to climate change. Our results showed that natural biogeographic factors still dominate in driving freshwater fish assemblage patterns despite increased human disturbances on aquatic ecosystems in a rapidly developing country. These findings consequently suggested that we should consider both natural (e.g., climate) and human (e.g., urbanization, inland fisheries) factors when establishing aquatic conservation strategies and priorities for developing countries that are experiencing rapid socio‐economic changes.

For common community phylogenetic analyses, go ahead and use synthesis phylogenies - Daijiang Li; Lauren Trotta; Hannah E. Marx; Julie M. Allen; Miao Sun; Douglas E. Soltis; Pamela S. Soltis; Robert P. Guralnick; Benjamin Baiser (Ecology, 2019)
Should we build our own phylogenetic trees based on gene sequence data, or can we simply use available synthesis phylogenies? This is a fundamental question that any study involving a phylogenetic framework must face at the beginning of the project. Building a phylogeny from gene sequence data (purpose‐built phylogeny) requires more effort, expertise, and cost than subsetting an already available phylogeny (synthesis‐based phylogeny). However, we still lack a comparison of how these two approaches to building phylogenetic trees influence common community phylogenetic analyses such as comparing community phylogenetic diversity and estimating trait phylogenetic signal. Here, we generated three purpose‐built phylogenies and their corresponding synthesis‐based trees (two from Phylomatic and one from the Open Tree of Life, OTL ). We simulated 1,000 communities and 12,000 continuous traits along each purpose‐built phylogeny. We then compared the effects of different trees on estimates of phylogenetic diversity (alpha and beta) and phylogenetic signal (Pagel's λ and Blomberg's K). Synthesis‐based phylogenies generally yielded higher estimates of phylogenetic diversity when compared to purpose‐built phylogenies. However, resulting measures of phylogenetic diversity from both types of phylogenies were highly correlated (Spearman's > 0.8 in most cases). Mean pairwise distance (both alpha and beta) is the index that is most robust to the differences in tree construction that we tested. Measures of phylogenetic diversity based on the OTL showed the highest correlation with measures based on the purpose‐built phylogenies. Trait phylogenetic signal estimated with synthesis‐based phylogenies, especially from the OTL , was also highly correlated with estimates of Blomberg's K or close to Pagel's λ from purpose‐built phylogenies when traits were simulated under Brownian motion. For commonly employed community phylogenetic analyses, our results justify taking advantage of recently developed and continuously improving synthesis trees, especially the Open Tree of Life.

Species interactions affect the spread of vector‐borne plant pathogens independent of transmission mode - David W. Crowder; Jing Li; Elizabeth T. Borer; Deborah L. Finke; Rakefet Sharon; David E. Pattemore; Jan Medlock (Ecology, 2019)
Within food webs, vectors of plant pathogens interact with individuals of other species across multiple trophic levels, including predators, competitors, and mutualists. These interactions may in turn affect vector‐borne pathogens by altering vector fitness and behavior. Predators, for example, consume vectors and reduce their abundance, but often spur movement of vectors as they seek to avoid predation. However, a general framework to predict how species interactions affect vectors of plant pathogens, and the resulting spread of vector‐borne pathogens, is lacking. Here we developed a mathematical model to assess whether interactions such as predation, competition, and mutualism affected the spread of vector‐borne plant pathogens with nonpersistent or persistent transmission modes. We considered transmission mode because interactions affecting vector–host encounter rates were expected to most strongly affect nonpersistent pathogens that are transmitted with short feeding bouts; interactions that affect vector feeding duration were expected to most strongly affect persistent pathogens that require long feeding bouts for transmission. Our results show that interactions that affected vector behavior (feeding duration, vector–host encounter rates) substantially altered rates of spread for vector‐borne plant pathogens, whereas those affecting vector fitness (births, deaths) had relatively small effects. These effects of species interactions were largely independent of transmission mode, except when interactions affected vector–host encounter rates, where effects were strongest for nonpersistent pathogens. Our results suggest that a better understanding of how vectors interact with other species within food webs could enhance our understanding of disease ecology.

Rapid Increases in Bat Activity and Diversity after Wetland Construction in an Urban Ecosystem - Kevin A. Parker; Brian T. Springall; Reuben A. Garshong; Ashley N. Malachi; Lauren E. Dorn; Alicia Costa-Terryll; Rachael A. Mathis; Alayna N. Lewis; Cassandra L. MacCheyne; Tronjay T. Davis; Alexis D. Rice; Nyla Y. Varh; et al. (Wetlands, 2019)

Fluorophenols bearing nitrogenated heterocycle moieties, a class of novel Keap1-Nrf2 protein-protein interaction inhibitors: synthesis, antioxidant stress screening and molecular docking - Xiu E Feng; De Peng Kong; Shu Rong Ban; Rui Ge; Qing Shan Li (Medicinal Chemistry Research, 2019)

Correction to: Internet gaming disorder: deficits in functional and structural connectivity in the ventral tegmental area-Accumbens pathway - Ruonan Wang; Min Li; Meng Zhao; Dahua Yu; Yu Hu; Corinde E. Wiers; Gene-Jack Wang; Nora D. Volkow; Kai Yuan (Brain Imaging and Behavior, 2019)

Internet gaming disorder: deficits in functional and structural connectivity in the ventral tegmental area-Accumbens pathway - Ruonan Wang; Min Li; Meng Zhao; Dahua Yu; Yu Hu; Corinde E. Wiers; Gene-Jack Wang; Nora D. Volkow; Kai Yuan (Brain Imaging and Behavior, 2019)

Anti-secretogranin III therapy of oxygen-induced retinopathy with optimal safety - Fen Tang; Michelle E. LeBlanc; Weiwen Wang; Dan Liang; Ping Chen; Tsung-Han Chou; Hong Tian; Wei Li (Angiogenesis, 2019)

Identifying loci with breeding potential across temperate and tropical adaptation via EigenGWAS and EnvGWAS - Jing Li; Guo‐Bo Chen; Awais Rasheed; Delin Li; Kai Sonder; Cristian Zavala Espinosa; Jiankang Wang; Denise E. Costich; Patrick S. Schnable; Sarah J. Hearne; Huihui Li (Molecular Ecology, 2019)
Understanding the genomic basis of adaptation in maize is important for gene discovery and the improvement of breeding germplasm, but much remains a mystery in spite of significant population genetics and archaeological research. Identifying the signals underpinning adaptation are challenging as adaptation often coincided with genetic drift, and the base genomic diversity of the species in massive. In this study, tGBS technology was used to genotype 1,143 diverse maize accessions including landraces collected from 20 countries and elite breeding lines of tropical lowland, highland, subtropical/midaltitude and temperate ecological zones. Based on 355,442 high‐quality single nucleotide polymorphisms, 13 genomic regions were detected as being under selection using the bottom‐up searching strategy, EigenGWAS. Of the 13 selection regions, 10 were first reported, two were associated with environmental parameters via EnvGWAS, and 146 genes were enriched. Combining large‐scale genomic and ecological data in this diverse maize panel, our study supports a polygenic adaptation model of maize and offers a framework to enhance our understanding of both the mechanistic basis and the evolutionary consequences of maize domestication and adaptation. The regions identified here are promising candidates for further, targeted exploration to identify beneficial alleles and haplotypes for deployment in maize breeding.

Reassessment of the 1907 Sumatra “Tsunami Earthquake” Based on Macroseismic, Seismological, and Tsunami Observations, and Modeling - Stacey Servito Martin; Linlin Li; Emile A. Okal; Julie Morin; Alexander E. G. Tetteroo; Adam D. Switzer; Kerry E. Sieh (Pure and Applied Geophysics, 2019)

Correction to: Genetic variant predictors of gene expression provide new insight into risk of colorectal cancer - Stephanie A. Bien; Yu-Ru Su; David V. Conti; Tabitha A. Harrison; Conghui Qu; Xingyi Guo; Yingchang Lu; Demetrius Albanes; Paul L. Auer; Barbara L. Banbury; Sonja I. Berndt; Stéphane Bézieau; et al. (Human Genetics, 2019)

Integration of Food Animal Residue Avoidance Databank (FARAD) empirical methods for drug withdrawal interval determination with a mechanistic population-based interactive physiologically based pharmacokinetic (iPBPK) modeling platform: example for flunixin meglumine administration - Miao Li; Yi-Hsien Cheng; Jason T. Chittenden; Ronald E. Baynes; Lisa A. Tell; Jennifer L. Davis; Thomas W. Vickroy; Jim E. Riviere; Zhoumeng Lin (Archives of Toxicology, 2019)

Spatial feedbacks and the dynamics of savanna and forest - Qianxiao Li; A. Carla Staver; Weinan E; Simon A. Levin (Theoretical Ecology, 2019)

Oreocharis rubrostriata (Gesneriaceae), a new species from Guangxi, China - Li-E Yang; Hua-Fei Cen; Hang Sun; Michael LoFurno; Stephen Maciejewski; Winston J. Goretsky; Fang Wen (Kew Bulletin, 2019)

Methods for monitoring construction off-road vehicle emissions: a critical review for identifying deficiencies and directions - Samad M. E. Sepasgozar; Heng Li; Sara Shirowzhan; Vivian W. Y. Tam (Environmental Science and Pollution Research, 2019)

Correction to: Neighborhood Parks and Recreationists' Exposure to Ozone: A Comparison of Disadvantaged and Affluent Communities in Los Angeles, California - Patricia L. Winter; Pamela E. Padgett; Lee-Anne S. Milburn; Weimin Li (Environmental Management, 2019)

Intravitreal Ets1 siRNA alleviates choroidal neovascularization in a mouse model of age-related macular degeneration - Manhui Zhu; Li Jiang; You Yuan; Lili Chen; Xiaojuan Liu; Juan Liang; Qiujian Zhu; Dongmei Ding; E. Song (Cell and Tissue Research, 2019)

The Construction of Full-Length cDNA Library for Otodectes cynotis - Li Hu; Ya-e Zhao; Dong-ling Niu; Rui Yang; Ji-hui Zeng (Acta Parasitologica, 2019)

A novel variant of Gh_D02G0276 is required for root-knot nematode resistance on chromosome 14 (D02) in Upland cotton - Martin J. Wubben; Gregory N. Thyssen; Franklin E. Callahan; David D. Fang; Dewayne D. Deng; Jack C. McCarty; Ping Li; Md Sariful Islam; Johnie N. Jenkins (Theoretical and Applied Genetics, 2019)

Interfacial Stress in the Development of Biologics: Fundamental Understanding, Current Practice, and Future Perspective - Jinjiang Li; Mary E. Krause; Xiaodong Chen; Yuan Cheng; Weiguo Dai; John J. Hill; Min Huang; Susan Jordan; Daniel LaCasse; Linda Narhi; Evgenyi Shalaev; Ian C. Shieh; et al. (The AAPS Journal, 2019)

Geophysical evidence for thrusting of crustal materials from orogenic belts over both sides of the Yangtze Block and its geological significance - Yingkang Li; Jianwei Gao; Jian Han; Yu’e Yang (Science China Earth Sciences, 2019)

Copy number variation of bovine SHH gene is associated with body conformation traits in Chinese beef cattle - Mei Liu; Bo Li; Tao Shi; Yongzhen Huang; George E. Liu; Xianyong Lan; Chuzhao Lei; Hong Chen (Journal of Applied Genetics, 2019)

Computational detection and experimental validation of segmental duplications and associated copy number variations in water buffalo ( Bubalus bubalis ) - Shuli Liu; Xiaolong Kang; Claudia R. Catacchio; Mei Liu; Lingzhao Fang; Steven G. Schroeder; Wenli Li; Benjamin D. Rosen; Daniela Iamartino; Leopoldo Iannuzzi; Tad S. Sonstegard; Curtis P. Van Tassell; et al. (Functional & Integrative Genomics, 2019)

Characterizing the changing environment of cropland in the Songnen Plain, Northeast China, from 1990 to 2015 - Yuan Zhang; Shuying Zang; Li Sun; Binghe Yan; Tianpeng Yang; Wenjia Yan; Michael E. Meadows; Cuizhen Wang; Jiaguo Qi (Journal of Geographical Sciences, 2019)

Sox11-modified mesenchymal stem cells accelerate cartilage defect repair in SD rats - Liangliang Xu; E Shunmei; Sien Lin; Yonghui Hou; Weiping Lin; Wei He; Haibin Wang; Gang Li (Cell and Tissue Research, 2019)

Life table invasion models: spatial progression and species‐specific partitioning - Zihua Zhao; Cang Hui; Richard E. Plant; Min Su; Tim Carpenter; Nikos Papadopoulos; Zhihong Li; James R. Carey (Ecology, 2019)
Biological invasions are increasingly being considered important spatial processes that drive global changes, threatening biodiversity, regional economies, and ecosystem functions. A unifying conceptual model of the invasion dynamics could serve as a useful tool for comparison and classification of invasion processes involving different species across large geographic ranges. By dividing these geographic ranges that are subject to invasions into discrete spatial units, we here conceptualize the invasion process as the transition from pristine to invaded spatial units. We use California cities as the spatial units and a long‐term database of invasive tropical tephritids to characterize the invasion patterns. A new life‐table method based on insect demography, including the progression model of invasion stage transition and the species‐specific partitioning model of multispecies invasions, was developed to analyze the invasion patterns. The progression model allows us to estimate the probability and rate of transition for individual cities from pristine to infested stages and subsequently differentiate the first year of detection from detection recurrences. Importantly, we show that the interval of invasive tephritid recurrence in a city declines with increasing invasion stages of the city. The species‐specific partitioning model revealed profound differences in invasion outcome depending on which tephritid species was first detected (and then locally eradicated) in the early stage of invasion. Taken together, we discuss how these two life‐table invasion models can cast new light on existing invasion concepts; in particular, on formulating invasion dynamics as the state transition of cities and partitioning species‐specific roles during multispecies invasions. These models provide a new set of tools for predicting the spatiotemporal progression of invasion and providing early warnings of recurrent invasions for efficient management.

Topological evolution of coexpression networks by new gene integration maintains the hierarchical and modular structures in human ancestors - Jian Zu; Yuexi Gu; Yu Li; Chentong Li; Wenyu Zhang; Yong E. Zhang; UnJin Lee; Li Zhang; Manyuan Long (Science China Life Sciences, 2019)

Timing and genesis of Cu–(Au) mineralization in the Khetri Copper Belt, northwestern India: constraints from in situ U–Pb ages and Sm–Nd isotopes of monazite-(Ce) - Xiao-Chun Li; Mei-Fu Zhou; A. E. Williams-Jones; Yue-Heng Yang; Jian-Feng Gao (Mineralium Deposita, 2019)

Cancer Survivorship Care Plan Utilization and Impact on Clinical Decision-Making at Point-of-Care Visits with Primary Care: Results from an Engineering, Primary Care, and Oncology Collaborative for Survivorship Health - SarahMaria Donohue; James E. Haine; Zhanhai Li; David A. Feldstein; Mark Micek; Elizabeth R. Trowbridge; Sandra A. Kamnetz; James M. Sosman; Lee G. Wilke; Mary E. Sesto; Amye J. Tevaarwerk (Journal of Cancer Education, 2019)

Genetic variant predictors of gene expression provide new insight into risk of colorectal cancer - Stephanie A. Bien; Yu-Ru Su; David V. Conti; Tabitha A. Harrison; Conghui Qu; Xingyi Guo; Yingchang Lu; Demetrius Albanes; Paul L. Auer; Barbara L. Banbury; Sonja I. Berndt; Stéphane Bézieau; et al. (Human Genetics, 2019)

The effect of rhizosphere microbes outweighs host plant genetics in reducing insect herbivory - Charley J. Hubbard; Baohua Li; Robby McMinn; Marcus T. Brock; Lois Maignien; Brent E. Ewers; Daniel Kliebenstein; Cynthia Weinig (Molecular Ecology, 2019)
Rhizosphere microbes affect plant performance, including plant resistance against insect herbivores; yet, a direct comparison of the relative influence of rhizosphere microbes versus plant genetics on herbivory levels and on metabolites related to defence is lacking. In the crucifer Boechera stricta , we tested the effects of rhizosphere microbes and plant population on herbivore resistance, the primary metabolome, and select secondary metabolites. Plant populations differed significantly in the concentrations of six glucosinolates (GLS), secondary metabolites known to provide herbivore resistance in the Brassicaceae. The population with lower GLS levels experienced ~60% higher levels of aphid ( Myzus persicae ) attack; no association was observed between GLS and damage by a second herbivore, flea beetles ( Phyllotreta cruciferae ). Rhizosphere microbiome (disrupted vs. intact native microbiome) had no effect on plant GLS concentrations. However, aphid number and flea beetle damage were respectively about three‐ and seven‐fold higher among plants grown in the disrupted versus intact native microbiome treatment. These differences may be attributable to shifts in primary metabolic pathways previously implicated in host defence against herbivores, including increases in pentose and glucoronate interconversion among plants grown with an intact microbiome. Furthermore, native microbiomes with distinct community composition (as estimated from 16s rRNA amplicon sequencing) differed two‐fold in their effect on host plant susceptibility to aphids. The findings suggest that rhizosphere microbes, including distinct native microbiomes, can play a greater role than population in defence against insect herbivores, and act through metabolic mechanisms independent of population.

CCR2 on Peripheral Blood CD14+CD16+ Monocytes Correlates with Neuronal Damage, HIV-Associated Neurocognitive Disorders, and Peripheral HIV DNA: reseeding of CNS reservoirs? - Mike Veenstra; Desiree A. Byrd; Matilde Inglese; Korhan Buyukturkoglu; Dionna W. Williams; Lazar Fleysher; Ming Li; Lucio Gama; Rosiris León-Rivera; Tina M. Calderon; Janice E. Clements; Susan Morgello; et al. (Journal of Neuroimmune Pharmacology, 2019)

Population-based estimates of the burden of pneumonia hospitalizations in Hong Kong, 2011–2015 - Xue Li; Joseph E. Blais; Ian C. K. Wong; Anthony W. Y. Tam; Benjamin J. Cowling; Ivan F. N. Hung; Esther W. Y. Chan (European Journal of Clinical Microbiology & Infectious Diseases, 2019)

Value of pre-operative CTX serum levels in the prediction of medication-related osteonecrosis of the jaw (MRONJ): a retrospective clinical study - Martin Salgueiro; Michael Stribos; Li Fang Zhang; Mark Stevens; Mohamed E. Awad; Mohammed Elsalanty (EPMA Journal, 2019)

Neighborhood Parks and Recreationists’ Exposure to Ozone: A Comparison of Disadvantaged and Affluent Communities in Los Angeles, California - Patricia L. Winter; Pamela E. Padgett; Lee-Anne S. Milburn; Weimin Li (Environmental Management, 2019)

Risk and dynamics of unprecedented hot months in South East China - Vikki Thompson; Nick J. Dunstone; Adam A. Scaife; Doug M. Smith; Steven C. Hardiman; Hong-Li Ren; Bo Lu; Stephen E. Belcher (Climate Dynamics, 2019)

Changes in retinal and choroidal morphology after cerebrospinal fluid pressure reduction: a Beijing iCOP study - Lu Liu; Xiaoxia Li; Hanspeter E. Killer; Kai Cao; Jing Li; Ningli Wang (Science China Life Sciences, 2019)

RETRACTED ARTICLE: Aluminum in Neurological and Neurodegenerative Disease - Donald R. C. McLachlan; Catherine Bergeron; Peter N. Alexandrov; William J. Walsh; Aileen I. Pogue; Maire E. Percy; Theodore P. A. Kruck; Zhide Fang; Nathan M. Sharfman; Vivian Jaber; Yuhai Zhao; Wenhong Li; et al. (Molecular Neurobiology, 2019)

Monogenic, Polygenic, and MicroRNA Markers for Ischemic Stroke - Wu Chen; Bharati Sinha; Yi Li; Larry Benowitz; Qinhua Chen; Zhenghong Zhang; Nirav J. Patel; Ali M. Aziz-Sultan; Antonio E. Chiocca; Xin Wang (Molecular Neurobiology, 2019)

Depositional mechanisms and morphology of debris flow: physical modelling - Gordon G. D. Zhou; Shuai Li; Dongri Song; Clarence E. Choi; Xiaoqing Chen (Landslides, 2019)

The Impact of a Primary Care Education Program Regarding Cancer Survivorship Care Plans: Results from an Engineering, Primary Care, and Oncology Collaborative for Survivorship Health - SarahMaria Donohue; James E. Haine; Zhanhai Li; Elizabeth R. Trowbridge; Sandra A. Kamnetz; David A. Feldstein; James M. Sosman; Lee G. Wilke; Mary E. Sesto; Amye J. Tevaarwerk (Journal of Cancer Education, 2019)

Theoretical study of the mechanism of the manganese catalase KatB - Xi-Xi Yang; Qiu-Yun Mao; Xiao-Ting An; Xi-Chen Li; Per E. M. Siegbahn; Guang-Ju Chen; Hong-Wei Tan (JBIC Journal of Biological Inorganic Chemistry, 2019)

Leveraging linkage evidence to identify low-frequency and rare variants on 16p13 associated with blood pressure using TOPMed whole genome sequencing data - Karen Y. He; Xiaoyin Li; Tanika N. Kelly; Jingjing Liang; Brian E. Cade; Themistocles L. Assimes; Lewis C. Becker; Amber L. Beitelshees; Adam P. Bress; Yen-Pei Christy Chang; Yii-Der Ida Chen; Paul S. de Vries; et al. (Human Genetics, 2019)

Effects of chronic kidney disease stage 4, end-stage renal disease, or dialysis on the plasma concentrations of ombitasvir, paritaprevir, ritonavir, and dasabuvir in patients with chronic HCV infection: pharmacokinetic analysis of the phase 3 RUBY-I and RUBY-II trials - Diana L. Shuster; Rajeev M. Menon; Bifeng Ding; Amit Khatri; Hong Li; Eric Cohen; Melissa Jewett; Daniel E. Cohen; Jiuhong Zha (European Journal of Clinical Pharmacology, 2019)

Adsorption performance and mechanisms of Pb(II), Cd(II), and Mn(II) removal by a β-cyclodextrin derivative - Mengjiao Zhang; Liyun Zhu; Changhua He; Xiaojun Xu; Zhengyang Duan; Shuli Liu; Mingyao Song; Shumin Song; Jiemei Shi; Yu’e Li; Guangzhu Cao (Environmental Science and Pollution Research, 2019)

Atmospheric histories, growth rates and solubilities in seawater and other natural waters of the potential transient tracers HCFC-22, HCFC-141b, HCFC-142b, HFC-134a, HFC-125, HFC-23, PFC-14 and PFC-116 - Pingyang Li; Jens Mühle; Stephen A. Montzka; David E. Oram; Benjamin R. Miller; Ray F. Weiss; Paul J. Fraser; Toste Tanhua (Ocean Science, 2019)
We present consistent annual mean atmospheric histories and growth rates for the mainly anthropogenic halogenated compounds HCFC-22, HCFC-141b, HCFC-142b, HFC-134a, HFC-125, HFC-23, PFC-14 and PFC-116, which are all potentially useful oceanic transient tracers (tracers of water transport within the ocean), for the Northern and Southern Hemisphere with the aim of providing input histories of these compounds for the equilibrium between the atmosphere and surface ocean. We use observations of these halogenated compounds made by the Advanced Global Atmospheric Gases Experiment (AGAGE), the Scripps Institution of Oceanography (SIO), the Commonwealth Scientific and Industrial Research Organization (CSIRO), the National Oceanic and Atmospheric Administration (NOAA) and the University of East Anglia (UEA). Prior to the direct observational record, we use archived air measurements, firn air measurements and published model calculations to estimate the atmospheric mole fraction histories. The results show that the atmospheric mole fractions for each species, except HCFC-141b and HCFC-142b, have been increasing since they were initially produced. Recently, the atmospheric growth rates have been decreasing for the HCFCs (HCFC-22, HCFC-141b and HCFC-142b), increasing for the HFCs (HFC-134a, HFC-125, HFC-23) and stable with little fluctuation for the PFCs (PFC-14 and PFC-116) investigated here. The atmospheric histories (source functions) and natural background mole fractions show that HCFC-22, HCFC-141b, HCFC-142b, HFC-134a, HFC-125 and HFC-23 have the potential to be oceanic transient tracers for the next few decades only because of the recently imposed bans on production and consumption. When the atmospheric histories of the compounds are not monotonically changing, the equilibrium atmospheric mole fraction (and ultimately the age associated with that mole fraction) calculated from their concentration in the ocean is not unique, reducing their potential as transient tracers. Moreover, HFCs have potential to be oceanic transient tracers for a longer period in the future than HCFCs as the growth rates of HFCs are increasing and those of HCFCs are decreasing in the background atmosphere. PFC-14 and PFC-116, however, have the potential to be tracers for longer periods into the future due to their extremely long lifetimes, steady atmospheric growth rates and no explicit ban on their emissions. In this work, we also derive solubility functions for HCFC-22, HCFC-141b, HCFC-142b, HFC-134a, HFC-125, HFC-23, PFC-14 and PFC-116 in water and seawater to facilitate their use as oceanic transient tracers. These functions are based on the Clark–Glew–Weiss (CGW) water solubility function fit and salting-out coefficients estimated by the poly-parameter linear free-energy relationships (pp-LFERs). Here we also provide three methods of seawater solubility estimation for more compounds. Even though our intention is for application in oceanic research, the work described in this paper is potentially useful for tracer studies in a wide range of natural waters, including freshwater and saline lakes, and, for the more stable compounds, groundwaters.

Construction of a high-density linkage map and QTL detection of downy mildew resistance in Vitis aestivalis-derived ‘Norton’ - Surya Sapkota; Li-Ling Chen; Shanshan Yang; Katie E. Hyma; Lance Cadle-Davidson; Chin-Feng Hwang (Theoretical and Applied Genetics, 2019)

Vertical distribution of fluorine in farmland soil profiles around phosphorous chemical industry factories - Mei Wang; Jin-yan Yang; Wen-yan He; Jin-xin Li; Yan-yuan Zhu; Xiao-e Yang (Environmental Science and Pollution Research, 2019)

Reproductive and menopausal factors and risk of second primary breast cancer after in situ breast carcinoma - Michelle L. Baglia; Mei-Tzu C. Tang; Kathleen E. Malone; Peggy Porter; Christopher I. Li (Cancer Causes & Control, 2019)

Irinotecan Alters the Disposition of Morphine Via Inhibition of Organic Cation Transporter 1 (OCT1) and 2 (OCT2) - Peng Zhu; Zhi Ye; Dong Guo; Zongping Xiong; Shiqiong Huang; Jun Guo; Wei Zhang; James E. Polli; Honghao Zhou; Qing Li; Yan Shu (Pharmaceutical Research, 2018)

Analyses of LMNA-negative juvenile progeroid cases confirms biallelic POLR3A mutations in Wiedemann–Rautenstrauch-like syndrome and expands the phenotypic spectrum of PYCR1 mutations - Davor Lessel; Ayse Bilge Ozel; Susan E. Campbell; Abdelkrim Saadi; Martin F. Arlt; Keisha Melodi McSweeney; Vasilica Plaiasu; Katalin Szakszon; Anna Szőllős; Cristina Rusu; Armando J. Rojas; Jaime Lopez-Valdez; et al. (Human Genetics, 2018)

Effect of lead on plant availability of phosphorus and potassium in a vegetable–soil system - Wen-yan He; Xiao-e Yang; Jin-yan Yang; Zhen-li He (Environmental Science and Pollution Research, 2018)

An integrated method for calculating DEM-based RUSLE LS - Meng Wang; Jantiene E. M. Baartman; Hongming Zhang; Qinke Yang; Shuqin Li; Jiangtao Yang; Cheng Cai; Meili Wang; Coen J. Ritsema; Violette Geissen (Earth Science Informatics, 2018)

Selective Inhibition on Organic Cation Transporters by Carvedilol Protects Mice from Cisplatin-Induced Nephrotoxicity - Dong Guo; Hong Yang; Qing Li; Hyo Jung Bae; Obinna Obianom; Sujuan Zeng; Tong Su; James E. Polli; Yan Shu (Pharmaceutical Research, 2018)

Label-Free Assessment of Collagenase Digestion on Bovine Pericardium Properties by Fluorescence Lifetime Imaging - Cai Li; Jeny Shklover; Mojtaba Parvizi; Benjamin E. Sherlock; Alba Alfonso Garcia; Anne K. Haudenschild; Leigh G. Griffiths; Laura Marcu (Annals of Biomedical Engineering, 2018)

Quantifying cold front induced water transport of a bay with in situ observations using manned and unmanned boats - Eddie Weeks; Mark E Robinson; Chunyan Li (Acta Oceanologica Sinica, 2018)

Emergence of soil bacterial ecotypes along a climate gradient - Alexander B. Chase; Zulema Gomez‐Lunar; Alberto E. Lopez; Junhui Li; Steven D. Allison; Adam C. Martiny; Jennifer B. H. Martiny (Environmental Microbiology, 2018)
Summary The high diversity of soil bacteria is attributed to the spatial complexity of soil systems, where habitat heterogeneity promotes niche partitioning among bacterial taxa. This premise remains challenging to test, however, as it requires quantifying the traits of closely related soil bacteria and relating these traits to bacterial abundances and geographic distributions. Here, we sought to investigate whether the widespread soil taxon Curtobacterium consists of multiple coexisting ecotypes with differential geographic distributions. We isolated Curtobacterium strains from six sites along a climate gradient and assayed four functional traits that may contribute to niche partitioning in leaf litter, the top layer of soil. Our results revealed that cultured isolates separated into fine‐scale genetic clusters that reflected distinct suites of phenotypic traits, denoting the existence of multiple ecotypes. We then quantified the distribution of Curtobacterium by analysing metagenomic data collected across the gradient over 18 months. Six abundant ecotypes were observed with differential abundances along the gradient, suggesting fine‐scale niche partitioning. However, we could not clearly explain observed geographic distributions of ecotypes by relating their traits to environmental variables. Thus, while we can resolve soil bacterial ecotypes, the traits delineating their distinct niches in the environment remain unclear.

Climatic response of Pinus cembroides Zucc. radial growth in Sierra del Cubo, Guanajuato, Mexico - Teodoro Carlón Allende; Manuel E. Mendoza; José Villanueva Díaz; Yanmei Li (Trees, 2018)

Genome-wide association study of primary open-angle glaucoma in continental and admixed African populations - Pieter W. M. Bonnemaijer; Adriana I. Iglesias; Girish N. Nadkarni; Anna J. Sanyiwa; Hassan G. Hassan; Colin Cook; Mark Simcoe; Kent D. Taylor; Claudia Schurmann; Gillian M. Belbin; Eimear E. Kenny; Erwin P. Bottinger; et al. (Human Genetics, 2018)

Fecal Bacteriome and Mycobiome in Bats with Diverse Diets in South China - Juan Li; Linmiao Li; Haiying Jiang; Lihong Yuan; Libiao Zhang; Jing-e Ma; Xiujuan Zhang; Minhua Cheng; Jinping Chen (Current Microbiology, 2018)

Racial variation in receipt of quality radiation therapy for prostate cancer - Daniel J. Lee; Zhiguo Zhao; Li-Ching Huang; Tatsuki Koyoma; Matthew J. Resnick; David F. Penson; Daniel A. Barocas; Karen E. Hoffman (Cancer Causes & Control, 2018)

Competition for electrons between mono-oxygenations of pyridine and 2-hydroxypyridine - Chao Yang; Yingxia Tang; Hua Xu; Ning Yan; Naiyu Li; Yongming Zhang; Bruce E. Rittmann (Biodegradation, 2018)

Anxiolytic potency of iridoid fraction extracted from Valeriana jatamansi Jones and its mechanism: a preliminary study - Xue-Mei Zhang; Jia-Li Zhu; Yong Sun; Yao-Lan Dai; Xiu Chen; Jia-Hong Cao; Ruo-Cong Yang; Chang Chen; Chao-Ying Ma; Tian-E Zhang; Yun-Hui Chen; Zhi-Yong Yan (Natural Product Research, 2018)

Climate change favours a destructive agricultural pest in temperate regions: late spring cold matters - Shimin Gu; Peng Han; Zhengpei Ye; Lynda E. Perkins; Jing Li; Huiqing Wang; Myron P. Zalucki; Zhaozhi Lu (Journal of Pest Science, 2018)

A process systems framework for rapid generation of life cycle inventories for pollution control and sustainability evaluation - Shuyun Li; Yacine Feliachi; Selorme Agbleze; Gerardo J. Ruiz-Mercado; Raymond L. Smith; David E. Meyer; Michael A. Gonzalez; Fernando V. Lima (Clean Technologies and Environmental Policy, 2018)

Comparative Biology of Cycad Pollen, Seed and Tissue - A Plant Conservation Perspective - J. Nadarajan; E. E. Benson; P. Xaba; K. Harding; A. Lindstrom; J. Donaldson; C. E. Seal; D. Kamoga; E. M. G. Agoo; N. Li; E. King; H. W. Pritchard (The Botanical Review, 2018)

Attributing high-impact extreme events across timescales—a case study of four different types of events - Friederike E. L. Otto; Sjoukje Philip; Sarah Kew; Sihan Li; Andrew King; Heidi Cullen (Climatic Change, 2018)

Collapse behavior and microstructural evolution of loess soils from the Loess Plateau of China - Wan-li Xie; Ping Li; Mao-sheng Zhang; Tian-e Cheng; Yong Wang (Journal of Mountain Science, 2018)

Taxonomy of the family Arenaviridae and the order Bunyavirales: update 2018 - Piet Maes; Sergey V. Alkhovsky; Yīmíng Bào; Martin Beer; Monica Birkhead; Thomas Briese; Michael J. Buchmeier; Charles H. Calisher; Rémi N. Charrel; Il Ryong Choi; Christopher S. Clegg; Juan Carlos de la Torre; et al. (Archives of Virology, 2018)

Skillful Seasonal Forecasts of Summer Surface Air Temperature in Western China by Global Seasonal Forecast System Version 5 - Chaofan Li; Riyu Lu; Philip E. Bett; Adam A. Scaife; Nicola Martin (Advances in Atmospheric Sciences, 2018)

Seasonal Forecasts of the Summer 2016 Yangtze River Basin Rainfall - Philip E. Bett; Adam A. Scaife; Chaofan Li; Chris Hewitt; Nicola Golding; Peiqun Zhang; Nick Dunstone; Doug M. Smith; Hazel E. Thornton; Riyu Lu; Hong-Li Ren (Advances in Atmospheric Sciences, 2018)

Responses of biotic interactions of dominant and subordinate species to decadal warming and simulated rotational grazing in Tibetan alpine meadow - Xin’e Li; Xiaoxue Zhu; Shiping Wang; Shujuan Cui; Caiyun Luo; Zhenhua Zhang; Lirong Zhang; Lili Jiang; Wangwang Lü (Science China Life Sciences, 2018)