Neuroprotective carbazole alkaloids from Streptomyces sp. HS-NF-1322 by inhibition of ferroptosis - Yuan Peng; Yi-Tong Luo; Qian-Qing Liu; Si-Qing Lou; Dong-E. Liang; Zha-Jun Zhan; Zhi-Fang Xi; Lie-Feng Ma (Phytochemistry Letters, 2023)

Two new metabolites from a marine-derived fungus Penicillium ochrochloron - Peter M. Eze; Yang Liu; Viktor E. Simons; Sherif S. Ebada; Tibor Kurtán; Sándor Balázs Király; Charles O. Esimone; Festus B.C. Okoye; Peter Proksch; Rainer Kalscheuer (Phytochemistry Letters, 2023)

Chocolate Consumption in Relation to All-Cause and Cause-Specific Mortality in Women: The Women’s Health Initiative - Yangbo Sun; Buyun Liu; Linda G. Snetselaar; Robert B. Wallace; Aladdin H. Shadyab; Guo-Chong Chen; James M. Shikany; JoAnn E. Manson; Wei Bao (Journal of the Academy of Nutrition and Dietetics, 2023)

Microbial diversity in stingless bee gut is linked to host wing size and influenced by the environment - Hongwei Liu; Mark A. Hall; Laura E. Brettell; Juntao Wang; Megan Halcroft; Scott Nacko; Robert Spooner-Hart; James M. Cook; Markus Riegler; Brajesh K. Singh (Journal of Invertebrate Pathology, 2023)

A rapid chemometrics model for antioxidant substance mining of Chinese dwarf cherry [Cerasus humilis (Bge.) Sok.] based on polyphenol profile and antioxidant capacity of 30 germplasms - Yushi Zhang; Qingyu Cui; Chang-e Guo; Xiaobing Zhang; Shupeng Liu; Xiaoxue Wang; Jinjiang Zhao; Zihan Zhao; Weidong Li (Food Bioscience, 2023)

Long-term application of controlled-release potassium chloride increases maize yield by affecting soil bacterial ecology, enzymatic activity and nutrient supply - Zeli Li; Lixue Qiu; Tianjiao Zhang; Gaoyang E; Lili Zhang; Lingli Wang; Liang Wu; Yanfeng Wang; Yunfeng Zhang; Jun Dong; Wenjing Li; Zhiguang Liu; et al. (Field Crops Research, 2023)

Associations between prenatal exposure to second hand smoke and infant self-regulation in a New York city longitudinal prospective birth cohort - Amy E. Margolis; Sang Han Lee; Ran Liu; Lindsay Goolsby; Frances Champagne; Julie Herbstman; Beatrice Beebe (Environmental Research, 2023)

Geomorphological characterization, remote sensing monitoring, and modeling of a slow-moving landslide in Alcoy (Southern Spain) - R. Tomás; E. Díaz; W. T. Szeibert; X. Liu; J. M. Lopez-Sanchez; C. Zhao (Landslides, 2023)

Treating colorectal peritoneal metastases with an injectable cytostatic loaded supramolecular hydrogel in a rodent animal model - Anne G. W. E. Wintjens; Hong Liu; Peter-Paul K.H. Fransen; Kaatje Lenaerts; Geert C. van Almen; Marion J. Gijbels; M’hamed Hadfoune; Bas T.C. Boonen; Natasja G. Lieuwes; Rianne Biemans; Ludwig J. Dubois; Patricia Y.W. Dankers; et al. (Clinical & Experimental Metastasis, 2023)
Patients with peritoneal metastases (PM) of colorectal cancer have a very poor outcome. Intraperitoneal delivery of chemotherapy is the preferred route for PM treatment. The main limitation of the treatment options is the short residence time of the cytostatic, with subsequent short exposure of the cancer cells. To address this, a supramolecular hydrogel has been developed that allows both local and slow release of its encapsulated drug, mitomycin C (MMC) or cholesterol-conjugated MMC (cMMC), respectively. This experimental study investigates if drug delivery using this hydrogel improves the therapeutic efficacy against PM. PM was induced in WAG/Rij rats (n = 72) by intraperitoneally injecting syngeneic colon carcinoma cells (CC531) expressing luciferase. After seven days, animals received a single intraperitoneal injection with saline (n = 8), unloaded hydrogel (n = 12), free MMC (n = 13), free cMMC (n = 13), MMC-loaded hydrogel (n = 13), or cMMC-loaded hydrogel (n = 13). Primary outcome was overall survival with a maximum follow-up of 120 days. Intraperitoneal tumor development was non-invasive monitored via bioluminescence imaging. Sixty-one rats successfully underwent all study procedures and were included to assess therapeutic efficacy. After 120 days, the overall survival in the MMC-loaded hydrogel and free MMC group was 78% and 38%, respectively. A trend toward significance was found when comparing the survival curves of the MMC-loaded hydrogel and free MMC (p = 0.087). No survival benefit was found for the cMMC-loaded hydrogel compared to free cMMC. Treating PM with our MMC-loaded hydrogel, exhibiting prolonged MMC exposure, seems effective in improving survival compared to treatment with free MMC.

Another Year of Record Heat for the Oceans - Lijing Cheng; John Abraham; Kevin E. Trenberth; John Fasullo; Tim Boyer; Michael E. Mann; Jiang Zhu; Fan Wang; Ricardo Locarnini; Yuanlong Li; Bin Zhang; Fujiang Yu; et al. (Advances in Atmospheric Sciences, 2023)
Changes in ocean heat content (OHC), salinity, and stratification provide critical indicators for changes in Earth’s energy and water cycles. These cycles have been profoundly altered due to the emission of greenhouse gasses and other anthropogenic substances by human activities, driving pervasive changes in Earth’s climate system. In 2022, the world’s oceans, as given by OHC, were again the hottest in the historical record and exceeded the previous 2021 record maximum. According to IAP/CAS data, the 0–2000 m OHC in 2022 exceeded that of 2021 by 10.9 ± 8.3 ZJ (1 Zetta Joules = 10 21 Joules); and according to NCEI/NOAA data, by 9.1 ± 8.7 ZJ. Among seven regions, four basins (the North Pacific, North Atlantic, the Mediterranean Sea, and southern oceans) recorded their highest OHC since the 1950s. The salinity-contrast index, a quantification of the “salty gets saltier—fresh gets fresher” pattern, also reached its highest level on record in 2022, implying continued amplification of the global hydrological cycle. Regional OHC and salinity changes in 2022 were dominated by a strong La Niña event. Global upper-ocean stratification continued its increasing trend and was among the top seven in 2022.

Macroalgae exhibit diverse responses to human disturbances on coral reefs - Sara E. Cannon; Simon D. Donner; Angela Liu; Pedro C. González Espinosa; Andrew H. Baird; Julia K. Baum; Andrew G. Bauman; Maria Beger; Cassandra E. Benkwitt; Matthew J. Birt; Yannick Chancerelle; Joshua E. Cinner; et al. (Global Change Biology, 2023)
Scientists and managers rely on indicator taxa such as coral and macroalgal cover to evaluate the effects of human disturbance on coral reefs, often assuming a universally positive relationship between local human disturbance and macroalgae. Despite evidence that macroalgae respond to local stressors in diverse ways, there have been few efforts to evaluate relationships between specific macroalgae taxa and local human‐driven disturbance. Using genus‐level monitoring data from 1205 sites in the Indian and Pacific Oceans, we assess whether macroalgae percent cover correlates with local human disturbance while accounting for factors that could obscure or confound relationships. Assessing macroalgae at genus level revealed that no genera were positively correlated with all human disturbance metrics. Instead, we found relationships between the division or genera of algae and specific human disturbances that were not detectable when pooling taxa into a single functional category, which is common to many analyses. The convention to use percent cover of macroalgae as an indication of local human disturbance therefore likely obscures signatures of local anthropogenic threats to reefs. Our limited understanding of relationships between human disturbance, macroalgae taxa, and their responses to human disturbances impedes the ability to diagnose and respond appropriately to these threats.

Combining exercise with cognitive training and vitamin D3 to improve functional brain connectivity (FBC) in older adults with mild cognitive impairment (MCI). Results from the SYNERGIC trial - Nick W. Bray; Frederico Pieruccini-Faria; Suzanne T. Witt; Robert Bartha; Timothy J. Doherty; Lindsay S. Nagamatsu; Quincy J. Almeida; Teresa Liu-Ambrose; Laura E. Middleton; Louis Bherer; Manuel Montero-Odasso (GeroScience, 2023)

Decreasing expression of Prohibitin-2 lowers the oncogenicity of renal cell carcinoma cells by suppressing eIF4E-mediated oncogene translation via MNK inhibition - Jie Yang; Gang Li; Yue'e Huang; Ying Liu (Toxicology and Applied Pharmacology, 2023)

Revised Paleozoic depositional history of the central Rocky Mountains (Utah and Colorado) - Paul M. Myrow; Michael Hasson; John F. Taylor; Lidya Tarhan; David A. Fike; Gerardo Ramirez; George Fowlkes; Leonid E. Popov; Hangyu Liu; Jitao Chen (Sedimentary Geology, 2023)

Artificial intelligence and real-world data for drug and food safety – A regulatory science perspective - Shraddha Thakkar; William Slikker; Frank Yiannas; Primal Silva; Burton Blais; Kern Rei Chng; Zhichao Liu; Alok Adholeya; Francesco Pappalardo; Mônica da Luz Carvalho Soares; Patrick E. Beeler; Maurice Whelan; et al. (Regulatory Toxicology and Pharmacology, 2023)

Dynamic Genomes - Mechanisms and consequences of genomic diversity impacting plant-fungal interactions - Jun Huang; Sanzhen Liu; David E. Cook (Physiological and Molecular Plant Pathology, 2023)

Analysis of the characteristics of the gas–liquid mixed artificial snow-making - Bin Liu; Hengxiang Hu; Lisen Bi; Panagiotis E. Theodorakis (International Journal of Refrigeration, 2023)

Machine learning and deep learning based on the small FT-MIR dataset for fine-grained sampling site recognition of boletus tomentipes - Jian-E Dong; Jieqing Li; Honggao Liu; Yuan-Zhong Wang (Food Research International, 2023)

Barriers to training Hmong produce farmers in the United States: A qualitative study - Pei Liu; Touria E. Eaton (Food Control, 2023)

Multidecadal pre- and post-collapse dynamics of the northern Larsen Ice Shelf - Shujie Wang; Hongxing Liu; Richard B. Alley; Kenneth Jezek; Patrick Alexander; Karen E. Alley; Zhengrui Huang; Lei Wang (Earth and Planetary Science Letters, 2023)

Mesoscale numerical simulation on the precipitation enhancement of stratiform clouds with embedded convection - Hui He; Xiang'e Liu; Lulin Xue; Qian Gao (Atmospheric Research, 2023)

Plant and fungal species interactions differ between aboveground and belowground habitats in mountain forests of eastern China - Teng Yang; Leho Tedersoo; Pamela S. Soltis; Douglas E. Soltis; Miao Sun; Yuying Ma; Yingying Ni; Xu Liu; Xiao Fu; Yu Shi; Han-Yang Lin; Yun-Peng Zhao; et al. (Science China Life Sciences, 2023)

A new anthraquinone from mangrove endophytic fungus Aspergillus sp. 16-5C - Ze’en Xiao; Shao’e Lin; Zhigang She; Yongjun Lu; Zhen Tan; Yonghong Liu (Natural Product Research, 2023)

RETRACTED ARTICLE: Nexus between economic policy uncertainty and green growth in BRICS countries: evidence from panel quantile regression - Yaofei Liu; Muhammad Sibt e Ali; Phan The Cong (Environmental Science and Pollution Research, 2023)

Assessing and optimizing the hydrological performance of Grey-Green infrastructure systems in response to climate change and non-stationary time series - Mo Wang; Ming Liu; Dongqing Zhang; Jinda Qi; Weicong Fu; Yu Zhang; Qiuyi Rao; Amin E. Bakhshipour; Soon Keat Tan (Water Research, 2023)

Assessing hydrological performance for optimized integrated grey-green infrastructure in response to climate change based on shared socio-economic pathways - Mo Wang; Ming Liu; Dongqing Zhang; Yu Zhang; Jin Su; Shiqi Zhou; Amin E. Bakhshipour; Soon Keat Tan (Sustainable Cities and Society, 2023)

Ustiloxin A inhibits proliferation of renal tubular epithelial cells in vitro and induces renal injury in mice by disrupting structure and respiratory function of mitochondria - Yongkang Zhang; Qiaolin Xu; Qian Sun; Ren Kong; Hao Liu; Xun’e Yi; Zhengqi Liang; Robert J. Letcher; Chunsheng Liu (Journal of Hazardous Materials, 2023)

Analysis of the effect of Rhodopseudomonas palustris on the lead exposure rat model using 1H-NMR-based metabolomics of urine and plasma - Shutong Chai; Ziyun Zheng; Yani Liu; Yanhui Liang; Hong Yang; Jie Chen; Hongjuan Bai; Guan-e Yang (Molecular & Cellular Toxicology, 2023)

Frailty and functional brain connectivity (FBC) in older adults with mild cognitive impairment (MCI): baseline results from the SYNERGIC Trial - Nick W. Bray; Frederico Pieruccini-Faria; Suzanne T. Witt; Kenneth Rockwood; Robert Bartha; Timothy J. Doherty; Lindsay S. Nagamatsu; Quincy J. Almeida; Teresa Liu-Ambrose; Laura E. Middleton; Louis Bherer; Manuel Montero-Odasso (GeroScience, 2023)

Characterization of a QTL on 7B for tiller number at the seedling stage in wheat landrace Yanda 1817 - Jian Yang; Yu’e Zhang; Weiguo Hu; Yanjie Zhou; Xicheng Wang; Hong Zhao; Shenghui Zhou; Zhiyong Liu; Tingjie Cao (Euphytica, 2023)

Long-term probabilistic temperature projections for all locations - Xin Chen; Adrian E. Raftery; David S. Battisti; Peiran R. Liu (Climate Dynamics, 2023)
The climate change projections of the Intergovernmental Panel on Climate Change are based on scenarios for future emissions, but these are not statistically-based and do not have a full probabilistic interpretation. Raftery et al. (Nat Clim Change 7:637–641, 2017) and Liu and Raftery (Commun Earth Environ 2:1–10, 2021) developed probabilistic forecasts for global average temperature change to 2100, but these do not give forecasts for specific parts of the globe. Here we develop a method for probabilistic long-term spatial forecasts of local average annual temperature change, combining the probabilistic global method with a pattern scaling approach. This yields a probability distribution for temperature in any year and any part of the globe in the future. Out-of-sample predictive validation experiments show the method to be well calibrated. Consistent with previous studies, we find that for long-term temperature changes, high latitudes warm more than low latitudes, continents more than oceans, and the Northern Hemisphere more than the Southern Hemisphere, except for the North Atlantic. There is a 5% chance that the temperature change for the Arctic would reach 16 $$^° $$ ∘ C. With probability 95%, the temperature of North Africa, West Asia and most of Europe will increase by at least 2 $$^° $$ ∘ C. We find that natural variability is a large part of the uncertainty in early years, but this declines so that by 2100 most of the overall uncertainty comes from model uncertainty and uncertainty about future emissions.

Carbon uptake in Eurasian boreal forests dominates the high‐latitude net ecosystem carbon budget - Jennifer D. Watts; Mary Farina; John S. Kimball; Luke D. Schiferl; Zhihua Liu; Kyle A. Arndt; Donatella Zona; Ashley Ballantyne; Eugénie S. Euskirchen; Frans‐Jan W. Parmentier; Manuel Helbig; Oliver Sonnentag; et al. (Global Change Biology, 2023)
Arctic‐boreal landscapes are experiencing profound warming, along with changes in ecosystem moisture status and disturbance from fire. This region is of global importance in terms of carbon feedbacks to climate, yet the sign (sink or source) and magnitude of the Arctic‐boreal carbon budget within recent years remains highly uncertain. Here, we provide new estimates of recent (2003–2015) vegetation gross primary productivity (GPP), ecosystem respiration ( R eco ), net ecosystem CO 2 exchange (NEE; R eco − GPP), and terrestrial methane (CH 4 ) emissions for the Arctic‐boreal zone using a satellite data‐driven process‐model for northern ecosystems (TCFM‐Arctic), calibrated and evaluated using measurements from >60 tower eddy covariance (EC) sites. We used TCFM‐Arctic to obtain daily 1‐km 2 flux estimates and annual carbon budgets for the pan‐Arctic‐boreal region. Across the domain, the model indicated an overall average NEE sink of −850 Tg CO 2 ‐C year −1 . Eurasian boreal zones, especially those in Siberia, contributed to a majority of the net sink. In contrast, the tundra biome was relatively carbon neutral (ranging from small sink to source). Regional CH 4 emissions from tundra and boreal wetlands (not accounting for aquatic CH 4 ) were estimated at 35 Tg CH 4 ‐C year −1 . Accounting for additional emissions from open water aquatic bodies and from fire, using available estimates from the literature, reduced the total regional NEE sink by 21% and shifted many far northern tundra landscapes, and some boreal forests, to a net carbon source. This assessment, based on in situ observations and models, improves our understanding of the high‐latitude carbon status and also indicates a continued need for integrated site‐to‐regional assessments to monitor the vulnerability of these ecosystems to climate change.

Association of the urinary polycyclic aromatic hydrocarbons with sex hormones stratified by menopausal status older than 20 years: a mixture analysis - Xihui Zhu; Yancen Meng; Yaru Ju; Yanjing Yang; Su’e Zhang; Liye Miao; Zhan Liu (Environmental Science and Pollution Research, 2023)

Recent advances in the fabrication of pH-sensitive indicators films and their application for food quality evaluation - Qingying Luo; Alomgir Hossen; Dur E Sameen; Saeed Ahmed; Jianwu Dai; Suqing Li; Wen Qin; Yaowen Liu (Critical Reviews in Food Science and Nutrition, 2023)

Far UV-C radiation: An emerging tool for pandemic control - Ernest R. Blatchley; David J. Brenner; Holger Claus; Troy E. Cowan; Karl G. Linden; Yijing Liu; Ted Mao; Sung-Jin Park; Patrick J. Piper; Richard M. Simons; David H. Sliney (Critical Reviews in Environmental Science and Technology, 2023)

Study on dust suppression performance of a new spray device during drilling and blasting construction in the metro tunnel - Ning Liu; Kun Chen; E. Deng; Weichao Yang; Youwu Wang (Tunnelling and Underground Space Technology, 2023)

Assessing aerobic biotransformation of 8:2 fluorotelomer alcohol in aqueous film-forming foam (AFFF)-impacted soils: Pathways and microbial community dynamics - Sheng Dong; Peng-Fei Yan; Chen Liu; Katherine E. Manz; Melissa P. Mezzari; Linda M. Abriola; Kurt D. Pennell; Natalie L. Cápiro (Journal of Hazardous Materials, 2023)

Simple and efficient solid phase extraction based on molecularly imprinted resorcinol–formaldehyde resin nanofibers for determination of trace sulfonamides in animal-origin foods - Yuanyuan Dai; Niu Wu; Li-e Liu; Fei Yu; Yongjun Wu; Ningge Jian (Food Chemistry, 2023)

Trends in elemental Pb concentrations within atmospheric PM2.5 and associated risk to human health in major cities of China - Qian Cui; Liangzhong Li; Yaqiang Cao; Bo Yang; Lindou Liu; Xiaoyan Dong; Yu'e Cha; Hongjie Ruan; Song Tang; Qiong Wang (Environmental Pollution, 2023)

A 1000-year hydroclimate record from the Asian summer monsoon-Westerlies transition zone in the northeastern Qinghai-Tibetan Plateau - Luo Qin; Guangxin Liu; Xiangzhong Li; E. Chongyi; Jiang Li; Changrun Wu; Xin Guan; Yuan Wang (Climatic Change, 2023)

Spatio‐temporal patterns in the woodiness of flowering plants - Ao Luo; Xiaoting Xu; Yunpeng Liu; Yaoqi Li; Xiangyan Su; Yichao Li; Tong Lyu; Dimitar Dimitrov; Markku Larjavaara; Shijia Peng; Yongsheng Chen; Qinggang Wang; et al. (Global Ecology and Biogeography, 2023)
Aim Woody and herbaceous habits represent one of the most distinct contrasts among angiosperms, and the proportion of woody species in floras (i.e., “woodiness” hereafter) represents a fundamental structural element of plant diversity. Despite its core influence on ecosystem processes, spatio‐temporal patterns in woodiness remain poorly understood. Here, we aim to demonstrate the global spatio‐temporal patterns in angiosperm woodiness and their relationship with environmental factors. Location Global. Time period Cenozoic, 66 Ma to present. Major taxa studied Angiosperms. Methods Using newly compiled data on the growth forms and distributions of c . 300,000 angiosperm species and an angiosperm phylogeny, we mapped the current global geographical patterns in angiosperm woodiness, reconstructed ancestral states of growth forms through the angiosperm phylogeny and demonstrated the Cenozoic evolutionary dynamics of woodiness. We evaluated the relationships between woodiness and current climate and palaeoclimate. Results We found that c . 42.7% of angiosperms are woody. Woodiness decreased spatially from the equator towards high latitudes, temporally since the early Cenozoic. Temperature was the best predictor of the spatio‐temporal decline in woodiness and was positively correlated with woodiness. Despite the temporal decline in woodiness, macroevolutionary herbaceous‐to‐woody transitions increased through time and contributed to the evolution of woody floras in temperate drylands, whereas the opposite transitions decreased through time and contributed to herbaceous floras in tropical and subtropical drylands. Main conclusions Our study improves understanding of the spatio‐temporal dynamics of angiosperm woodiness. Our findings suggest that temperature is likely to be a determinant of spatio‐temporal variations in woodiness, highlighting the role of temperature in maintaining the growth form composition of ecosystems. Our study also calls for attention to growth form transitions (e.g., secondary woodiness) in temperate drylands that have been neglected before.

A critical thermal transition driving spring phenology of Northern Hemisphere conifers - Jian‐Guo Huang; Yaling Zhang; Minhuang Wang; Xiaohan Yu; Annie Deslauriers; Patrick Fonti; Eryuan Liang; Harri Mäkinen; Walter Oberhuber; Cyrille B. K. Rathgeber; Roberto Tognetti; Václav Treml; et al. (Global Change Biology, 2023)
Despite growing interest in predicting plant phenological shifts, advanced spring phenology by global climate change remains debated. Evidence documenting either small or large advancement of spring phenology to rising temperature over the spatio‐temporal scales implies a potential existence of a thermal threshold in the responses of forests to global warming. We collected a unique data set of xylem cell‐wall‐thickening onset dates in 20 coniferous species covering a broad mean annual temperature (MAT) gradient (−3.05 to 22.9°C) across the Northern Hemisphere (latitudes 23°–66° N). Along the MAT gradient, we identified a threshold temperature (using segmented regression) of 4.9 ± 1.1°C, above which the response of xylem phenology to rising temperatures significantly decline. This threshold separates the Northern Hemisphere conifers into cold and warm thermal niches, with MAT and spring forcing being the primary drivers for the onset dates (estimated by linear and Bayesian mixed‐effect models), respectively. The identified thermal threshold should be integrated into the Earth‐System‐Models for a better understanding of spring phenology in response to global warming and an improved prediction of global climate‐carbon feedbacks.

Microbiome resilience of Amazonian forests: Agroforest divergence to bacteria and secondary forest succession convergence to fungi - Márcio Fernandes Alves Leite; Binbin Liu; Ernesto Gómez Cardozo; Hulda Rocha e Silva; Ronildson Lima Luz; Karol Henry Mavisoy Muchavisoy; Flávio Henrique Reis Moraes; Guillaume Xavier Rousseau; George Kowalchuk; Christoph Gehring; Eiko Eurya Kuramae (Global Change Biology, 2023)
An alarming and increasing deforestation rate threatens Amazon tropical ecosystems and subsequent degradation due to frequent fires. Agroforestry systems (AFS) may offer a sustainable alternative, reportedly mimicking the plant–soil interactions of the natural mature forest (MF). However, the role of microbial community in tropical AFS remains largely unknown. This knowledge is crucial for evaluating the sustainability of AFS and practices given the key role of microbes in the aboveground–belowground interactions. The current study, by comparing different AFS and successions of secondary and MFs, showed that AFS fostered distinct groups of bacterial community, diverging from the MFs, likely a result of management practices while secondary forests converged to the same soil microbiome found in the MF, by favoring the same groups of fungi. Model simulations reveal that AFS would require profound changes in aboveground biomass and in soil factors to reach the same microbiome found in MFs. In summary, AFS practices did not result in ecosystems mimicking natural forest plant–soil interactions but rather reshaped the ecosystem to a completely different relation between aboveground biomass, soil abiotic properties, and the soil microbiome.

How Comamonas testosteroni and Rhodococcus ruber enhance nitrification in the presence of quinoline - Ge Zhu; Haiyun Zhang; Ru Yuan; Meng Huang; Fei Liu; Mo Li; Yongming Zhang; Bruce E. Rittmann (Water Research, 2023)

Loss of microbial diversity weakens specific soil functions, but increases soil ecosystem stability - Xueling Yang; Jie Cheng; Ashley E. Franks; Xiaowei Huang; Qi Yang; Zhongyi Cheng; Yuanhui Liu; Bin Ma; Jianming Xu; Yan He (Soil Biology and Biochemistry, 2023)

A U-shaped spray device on a front boom-type roadheader for dust suppression in a metro tunnel - Ning Liu; Xiong Wu; E. Deng; Xinyuan Liu; Youwu Wang (Sustainable Cities and Society, 2023)

Multi-stage planning of LID-GREI urban drainage systems in response to land-use changes - Yu Zhang; Mo Wang; Dongqing Zhang; Zhongming Lu; Amin E. Bakhshipour; Ming Liu; Zhiyu Jiang; Jianjun Li; Soon Keat Tan (Science of The Total Environment, 2023)

Rapid nitrification using nitrifying biomass acclimated to sulfamethoxazole (SMX) - Xinyue Zhang; Jiayu Huang; Song Chen; Ning Yan; Rui Liu; Yongming Zhang; Bruce E. Rittmann (Journal of Environmental Chemical Engineering, 2023)

Correlation to predict conditions that lead to liquid-flooding at compressor start-up as a function of evaporator size and fluid properties - Leon P.M. Brendel; Smrithi Pranatharthi Haran; Haotian Liu; James E. Braun; Eckhard A. Groll (International Journal of Refrigeration, 2023)

Ground surface temperature monitoring data analysis and applications to geothermal exploration in volcanic areas, Mount Meager, western Canada - Zhuoheng Chen; Stephen E. Grasby; Wanju Yuan; Xiaojun Liu (Geothermics, 2023)

Diverse oxygen isotopic compositions among cometary vapor-phase condensates - Kainen L. Utt; Ryan C. Ogliore; Nan Liu; Alexander N. Krot; John P. Bradley; Donald E. Brownlee; David J. Joswiak (Geochimica et Cosmochimica Acta, 2023)

Performance comparison of black liquor gasification and oxidation in supercritical water from thermodynamic, environmental, and techno-economic perspectives - Jiamin Liang; Yang Liu; Jingwei Chen; Jiaqiang E; Erwei Leng; Feng Zhang; Gaoliang Liao (Fuel, 2023)

A coupling analysis method of foundation soil dynamic responses induced by metro train based on PDEM and stochastic field theory - E Deng; Xin-Yuan Liu; Yi-Qing Ni; You-Wu Wang; Chen-Yang Zhao (Computers and Geotechnics, 2023)

Calcification of cell membranes: From ions to minerals - Xiao Gao; Jie Li; Kaiming Hu; Yanyang Zhao; Yu Han; Fang Liu; Maurice E. Tucker; Zuozhen Han (Chemical Geology, 2023)

Oxidative stress induced by plasma-activated water stimulates astaxanthin production in Phaffia rhodozyma - Wenshao Li; Carlos H. Luna-Flores; Raveendra Anangi; Renwu Zhou; Xinle Tan; Marius Jessen; Lian Liu; Rusen Zhou; Tianqi Zhang; Alexander Gissibl; Patrick J. Cullen; Kostya (Ken) Ostrikov; et al. (Bioresource Technology, 2023)

Retrospective analysis of measures to reduce large whale entanglements in a lucrative commercial fishery - Leena Riekkola; Owen R. Liu; Blake E. Feist; Karin A. Forney; Briana Abrahms; Elliott L. Hazen; Jameal F. Samhouri (Biological Conservation, 2023)

Development and Evaluation of High-Density SNP Arrays for the Eastern Oyster Crassostrea virginica - Ximing Guo; Jonathan B. Puritz; Zhenwei Wang; Dina Proestou; Standish Allen; Jessica Small; Klara Verbyla; Honggang Zhao; Jaime Haggard; Noah Chriss; Dan Zeng; Kathryn Lundgren; et al. (Marine Biotechnology, 2023)

Potato wilt caused by co-infection of Fusarium spp. and Verticillium dahliae in potato plants - Ruifang Jia; Liru Kang; Mandela E. Addrah; Jian Zhang; Limin Xu; Zhiwei Zhang; Weidong Chen; Jiecai Liu; Jun Zhao (European Journal of Plant Pathology, 2023)

The East Asian Summer Monsoon Response to Global Warming in a High Resolution Coupled Model: Mean and Extremes - Zhen Liu; Sun-Seon Lee; Arjun Babu Nellikkattil; June-Yi Lee; Lan Dai; Kyung-Ja Ha; Christian L. E. Franzke (Asia-Pacific Journal of Atmospheric Sciences, 2023)
Current climate models still have considerable biases in the simulation of the East Asian summer monsoon (EASM), which in turn reduces their reliability of monsoon projections under global warming. We hypothesize that a higher-resolution coupled climate model with atmospheric and oceanic components at horizontal resolutions of 0.25° and 0.1°, respectively, will better capture regional details and extremes of the EASM. Present-day (PD), 2 × CO 2 and 4 × CO 2 simulations are conducted with the Community Earth System Model (CESM1.2.2) to evaluate PD simulation performance and quantify future changes. Indeed, our PD simulation well reproduces the climatological seasonal mean and intra-seasonal northward advancement of the monsoon rainband, as well as climate extremes. Compared with the PD simulation, the perturbed CO 2 experiments show an intensified EASM response to CO 2 -induced warming. We find that the precipitation increases of the Meiyu-Baiu-Changma band are caused by comparable contributions from the dynamical and thermodynamical components in 2 × CO 2 , while they are more driven by the thermodynamical component in 4 × CO 2 due to stronger upper atmospheric stability. The regional changes in the probability distribution of the temperature show that extreme temperatures warm faster than the most often temperatures, increasing the skewness. Fitting extreme precipitation values with a generalized Pareto distribution model reveals that they increase significantly in 4 × CO 2 . Changes of temperature extremes scale with the CO 2 concentrations over the monsoon domain but not for precipitation extreme changes. The 99 th percentile of precipitation over the monsoon region increases at a super Clausius-Clapeyron rate, ~ 8% K –1 , which is mainly caused by increased moisture transport through anomalous southerly winds.

RecruitNet : A global database of plant recruitment networks - Miguel Verdú; Jose L. Garrido; Julio M. Alcántara; Alicia Montesinos‐Navarro; Salomón Aguilar; Marcelo A. Aizen; Ali A. Al‐Namazi; Mohamed Alifriqui; David Allen; Kristina J. Anderson‐Teixeira; Cristina Armas; Jesús M. Bastida; et al. (Ecology, 2023)
Plant recruitment interactions (i.e., what recruits under what) shape the composition, diversity, and structure of plant communities. Despite the huge body of knowledge on the mechanisms underlying recruitment interactions among species, we still know little about the structure of the recruitment networks emerging in ecological communities. Modeling and analyzing the community‐level structure of plant recruitment interactions as a complex network can provide relevant information on ecological and evolutionary processes acting both at the species and ecosystem levels. We report a data set containing 143 plant recruitment networks in 23 countries across five continents, including temperate and tropical ecosystems. Each network identifies the species under which another species recruits. All networks report the number of recruits (i.e., individuals) per species. The data set includes >850,000 recruiting individuals involved in 118,411 paired interactions among 3318 vascular plant species across the globe. The cover of canopy species and open ground is also provided. Three sampling protocols were used: (1) The Recruitment Network (RN) protocol (106 networks) focuses on interactions among established plants (“canopy species”) and plants in their early stages of recruitment (“recruit species”). A series of plots was delimited within a locality, and all the individuals recruiting and their canopy species were identified; (2) The paired Canopy‐Open (pCO) protocol (26 networks) consists in locating a potential canopy plant and identifying recruiting individuals under the canopy and in a nearby open space of the same area; (3) The Georeferenced plot (GP) protocol (11 networks) consists in using information from georeferenced individual plants in large plots to infer canopy‐recruit interactions. Some networks incorporate data for both herbs and woody species, whereas others focus exclusively on woody species. The location of each study site, geographical coordinates, country, locality, responsible author, sampling dates, sampling method, and life habits of both canopy and recruit species are provided. This database will allow researchers to test ecological, biogeographical, and evolutionary hypotheses related to plant recruitment interactions. There are no copyright restrictions on the data set; please cite this data paper when using these data in publications.

Appraisal of climate change and source of heavy metals, sediments in water of the Kunhar River watershed, Pakistan - Shan-e-hyder Soomro; Xiaotao Shi; Jiali Guo; Caihong Hu; Haider M. Zwain; Chengshuai Liu; Muhammad Zeb Khan; Chaojie Niu; Chenchen Zhao; Zubair Ahmed (Natural Hazards, 2023)

Implicit satiety goals and food-related expectations predict portion size in older adults: Findings from the BAMMBE cohort - Aimee E. Pink; Li Ling Lee; Dorrain Yanwen Low; Yifan Yang; LaiGuan Zoey Fong; Alicia Yi Hui Kang; Peijia Liu; Hyejin Kim; Yulan Wang; Parasuraman Padmanabhan; Lynne Cobiac; Balázs Gulyás; et al. (Appetite, 2023)

Environmental-friendly hydrochar-montmorillonite composite for efficient catalytic degradation of dicamba and alleviating its damage to crops - Chunxia Ding; Guangyong Zeng; Yaping Tao; Xiuyu Long; Daoxin Gong; Nan Zhou; Rongying Zeng; Xiangying Liu; Yaocheng Deng; Mei-E Zhong (Science of The Total Environment, 2023)

In situ formed CaSO4 on waste dander biochar to inhibit the mineralization of soil organic carbon - Cheng Ji; Shuyi Yang; Ying Cheng; Lin Liu; Daohan Wang; Shujing Zhu; Tao E; Yun Li (Science of The Total Environment, 2023)

Nutrient dynamics and microbial community response in macrophyte-dominated lakes: Implications for improved restoration strategies - Shuai Ma; Huanhuan Geng; Changchun Yan; Xiaomin Han; Dan Xu; Furong Zhao; Ruth E. Blake; Beihai Zhou; Huilun Chen; Rongfang Yuan; Baoshi Jin; Haijun Liu; et al. (Journal of Environmental Management, 2023)

Mobility and flexibility enable resilience of human harvesters to environmental perturbation - Owen R. Liu; Mary Fisher; Blake E. Feist; Briana Abrahms; Kate Richerson; Jameal F. Samhouri (Global Environmental Change, 2023)

Experimental and theoretical study of the catalytic effects of potassium and calcium additives on the pyrolysis of β-O-4 type lignin model compounds - Yilin Guo; Yang Fang; Xun Gong; Shuai Liu; Hong Tian; Jingwei Chen; Jiaqiang E; Erwei Leng (Fuel, 2023)

Presence of novel and legacy flame retardants and other pollutants in an e-waste site in China and associated risks - Pablo Zapata-Corella; Zi-He Ren; Yin-E Liu; Anna Rigol; Silvia Lacorte; Xiao-Jun Luo (Environmental Research, 2023)

Analysis of steel baffle installed on footing with dowels for resisting boulder impact - Charles W.W. Ng; Dingchen Zhang; Clarence E. Choi; Haiming Liu; Raymond C.H. Koo; Rui Chen (Engineering Geology, 2023)

Otoliths of marine fishes record evidence of low oxygen, temperature and pH conditions of deep Oxygen Minimum Zones - Leticia Maria Cavole; Karin E. Limburg; Natalya D. Gallo; Anne Gro Vea Salvanes; Arturo Ramírez-Valdez; Lisa A. Levin; Octavio Aburto Oropeza; Andreas Hertwig; Ming-Chang Liu; Kevin D. McKeegan (Deep Sea Research Part I: Oceanographic Research Papers, 2023)

Toughing epoxy nanocomposites with graphene-encapsulated liquid metal framework - Da Li; E Peng; Fei Lu; Baolong Wang; Yibo Shen; Pengxiang Liu; Li Liu; Yudong Huang; Zhen Hu (Chemical Engineering Journal, 2023)

Regulating monolayer WO4 tetrahedral units to promote a sustainable 4,4-Bisphenol-A industrial process - San Hua Lim; Shibo Xi; Takashi Sato; Norikazu Konishi; Jia'E Zheng; Yan Liu; Masaru Utsunomiya; Armando Borgna (Chemical Engineering Journal, 2023)

Differential effects of soil texture and root traits on the spatial variability of soil infiltrability under natural revegetation in the Loess Plateau of China - Peipei Wang; Xuemeng Su; Zhengchao Zhou; Ning Wang; Jun'e Liu; Bingbing Zhu (CATENA, 2023)

Distribution of diatoms in seafloor surface sediments of the Laptev, East Siberian, and Chukchi seas: implication for environmental reconstructions - Maria S. Obrezkova; Ira B. Tsoy; Anastasya E. Kolyada; Xuefa Shi; Yanguang Liu (Polar Biology, 2023)

Improved assessment of rainfall-induced railway infrastructure risk in China using empirical data - Weihua Zhu; Kai Liu; Ming Wang; Sadhana Nirandjan; Elco E. Koks (Natural Hazards, 2023)

Tilapia introduction in China: Economic boom in aquaculture versus ecological threats to ecosystems - Wen Xiong; Chuanbo Guo; Rodolphe E. Gozlan; Jiashou Liu (Reviews in Aquaculture, 2023)
The introduction and use of non‐native species in aquaculture have played a central role in the development of this economic sector worldwide. Tilapia is one of the most widely introduced species in the world, and China has become the largest producer and consumer of tilapia. While non‐native tilapia in China support provisioning ecosystem services of substantial economic value, the invasion also poses potential threats to native fish diversity, ecosystems and ultimately the sustainable fisheries development. However, knowledge regarding the invading pathway, aquaculture development, economic benefits and the ecological impacts of such important non‐native species is still limited, especially in China. Based on thorough literature review as well as field surveys, this paper has comprehensively presented the introduction of tilapia species across a range of aquatic habitats and its role in the aquaculture industry growth, emphasising the economic benefits in China. In addition, we also synthesised the potential negative ecological impacts caused by tilapia invasion with global evidences, which will provide excellent lessons and management recommendations for China and other countries worldwide. Future trends tend to indicate an increase in the number and frequency of tilapia's introduction in China, with an increasing likelihood of environmental impacts. However, it is apparent that the aquaculture of non‐native tilapias is a highly profitable activity in China which makes the introductions inevitable, therefore, alternative management strategies and implications are further discussed to seek to achieve more sustainable and ecosystem‐friendly aquaculture, reduce the risks and negative impacts on ecosystems while still maintaining the economic benefits.

Expansion of Human Megakaryocyte-Lineage Progeny via Aryl Hydrocarbon Receptor Antagonism with CH223191 - Dongchan Kim; Dong-Yeop Shin; Jun Liu; Na-rae Jeong; Youngil Koh; Junshik Hong; Xinxin Huang; Hal E. Broxmeyer; Sung-Soo Yoon (Stem Cell Reviews and Reports, 2022)

Hyperspectral imaging predicts yield and nitrogen content in grass–legume polycultures - K. R. Ball; H. Liu; C. Brien; B. Berger; S. A. Power; E. Pendall (Precision Agriculture, 2022)

Mitochondrial Localization of SARM1 in Acrylamide Intoxication Induces Mitophagy and Limits Neuropathy - Shuai Wang; Mingxue Song; Hui Yong; Cuiqin Zhang; Kang Kang; Zhidan Liu; Yiyu Yang; Zhengcheng Huang; Shu’e Wang; Haotong Ge; Xiulan Zhao; Fuyong Song (Molecular Neurobiology, 2022)

An interaction of inorganic arsenic exposure with body weight and composition on type 2 diabetes indicators in Diversity Outbred mice - James G. Xenakis; Christelle Douillet; Timothy A. Bell; Pablo Hock; Joseph Farrington; Tianyi Liu; Caroline E. Y. Murphy; Avani Saraswatula; Ginger D. Shaw; Gustavo Nativio; Qing Shi; Abhishek Venkatratnam; et al. (Mammalian Genome, 2022)

Acute vs. chronic vs. intermittent hypoxia in breast Cancer: a review on its application in in vitro research - Qiuyu Liu; Victoria A.C. Palmgren; Erik HJ Danen; Sylvia E. Le Dévédec (Molecular Biology Reports, 2022)
Hypoxia has been linked to elevated instances of therapeutic resistance in breast cancer. The exposure of proliferating cancer cells to hypoxia has been shown to induce an aggressive phenotype conducive to invasion and metastasis. Regions of the primary tumors in the breast may be exposed to different types of hypoxia including acute, chronic or intermittent. Intermittent hypoxia (IH), also called cyclic hypoxia, is caused by exposure to cycles of hypoxia and reoxygenation (H-R cycles). Importantly, there is currently no consensus amongst the scientific community on the total duration of hypoxia, the oxygen level, and the possible presence of H-R cycles. In this review, we discuss current methods of hypoxia research, to explore how exposure regimes used in experiments are connected to signaling by different hypoxia inducible factors (HIFs) and to distinct cellular responses in the context of the hallmarks of cancer. We highlight discrepancies in the existing literature on hypoxia research within the field of breast cancer in particular and propose a clear definition of acute, chronic, and intermittent hypoxia based on HIF activation and cellular responses: (i) acute hypoxia is when the cells are exposed for no more than 24 h to an environment with 1% O 2 or less; (ii) chronic hypoxia is when the cells are exposed for more than 48 h to an environment with 1% O 2 or less and (iii) intermittent hypoxia is when the cells are exposed to at least two rounds of hypoxia (1% O 2 or less) separated by at least one period of reoxygenation by exposure to normoxia (8.5% O 2 or higher). Our review provides for the first time a guideline for definition of hypoxia related terms and a clear foundation for hypoxia related in vitro (breast) cancer research.

Effects of polysaccharides on the hydrodynamic parameters of sheet erosion on loessial slopes - Liting Yang; Jun’e Liu; Xiaoqian Qi; Xike Cheng; Chunyan Ma; Zhanli Wang (Environmental Science and Pollution Research, 2022)

Astrocyte-derived lactate/NADH alters methamphetamine-induced memory consolidation and retrieval by regulating neuronal synaptic plasticity in the dorsal hippocampus - Xu Tan; Xiaoyu Liu; E Liu; Min Liu; Shouhong Mu; Zhaofang Hang; Weikai Han; Tingting Wang; Yang Zhang; Jing Zhang; Qingwei Yue; Jinhao Sun (Brain Structure and Function, 2022)

Anti-drug Antibody Sample Testing and Reporting Harmonization - Darshana Jani; Robin Marsden; Michele Gunsior; Laura Schild Hay; Bethany Ward; Kyra J. Cowan; Mitra Azadeh; Breann Barker; Liching Cao; Kristin R. Closson; Kelly Coble; Sanjay L. Dholakiya; et al. (The AAPS Journal, 2022)
A clear scientific and operational need exists for harmonized bioanalytical immunogenicity study reporting to facilitate communication of immunogenicity findings and expedient review by industry and health authorities. To address these key bioanalytical reporting gaps and provide a report structure for documenting immunogenicity results, this cross-industry group was formed to establish harmonized recommendations and a develop a submission template to facilitate agency filings. Provided here are recommendations for reporting clinical anti-drug antibody (ADA) assay results using ligand-binding assay technologies. This publication describes the essential bioanalytical report (BAR) elements such as the method, critical reagents and equipment, study samples, results, and data analysis, and provides a template for a suggested structure for the ADA BAR. This publication focuses on the content and presentation of the bioanalytical ADA sample analysis report. The interpretation of immunogenicity data, including the evaluation of the impact of ADA on safety, exposure, and efficacy, is out of scope of this publication. Graphical Abstract

Predictors of muscle hypertrophy responsiveness to electrically evoked resistance training after spinal cord injury - Ashraf S. Gorgey; Jacob A. Goldsmith; Refka E. Khalil; Xin-hua Liu; Jiangping Pan; Christopher Cardozo; Robert A. Adler (European Journal of Applied Physiology, 2022)

Effect of posaconazole on the concentration of intravenous and oral cyclosporine in patients undergoing hematopoietic stem cell transplantation - Li-E Zhu; Hui-Ping Huang; Yi-Peng Cai; Yan Wang; Bao-Hua Xu; Mao-Bai Liu; Xue-Mei Wu (European Journal of Clinical Pharmacology, 2022)

Genome-wide identification of the MAPK gene family in turbot and its involvement in abiotic and biotic stress responses - Weiwei Zheng; Xi-wen Xu; Zechen E; Yingjie Liu; Songlin Chen (Frontiers in Marine Science, 2022)
The mitogen-activated protein kinase (MAPK) gene family performs crucial roles in cell division, migration, development, apoptosis, inflammatory response, and abiotic and biotic stress responses. However, very little information is available about the MAPKs in turbot ( Scophthalmus maximus ). In this study, 15 turbot MAPKs ( Sm MAPKs) were identified throughout the whole genome, and their basic chemical and physical properties and subcellular localization were illustrated. All Sm MAPKs contained the serine/threonine protein kinases, catalytic domain (S_TKc, SMART00220). Phylogenetic analysis revealed that Sm MAPKs were classified into three subfamilies, namely, c-Jun NH 2 -terminal kinase (JNK), extracellular signal-regulated kinase (ERK), and p38. Conserved motif and gene structure analysis revealed high levels of conservation within and between phylogenetic subfamilies. Expression patterns of MAPKs in distinct tissues and under diverse abiotic and biotic stresses were examined using the published available RNA-seq data sets. As a result, Sm MAPKs showed obviously tissue-specific expression. Furthermore, 7 and 10 candidate stress-responsive MAPK genes were detected under abiotic and biotic stresses, respectively, among which five common MAPK genes, namely, Sm MAPK4 (ERK4), Sm MAPK6 (ERK3), Sm MAPK11 (p38β), Sm MAPK12b (p38γ), and Sm MAPK15 (ERK7/8) showed extremely significant responses to both abiotic and biotic stresses, demonstrating their potential functions in comprehensive antistress. These results demonstrate that MAPKs might play vital roles in response to various abiotic and biotic stresses in turbot, which would contribute to making scientific preventive measures to environmental changes in the process of farming and promoting the development of selective breeding for comprehensive stress resistance in turbot.

Tallo: A global tree allometry and crown architecture database - Tommaso Jucker; Fabian Jörg Fischer; Jérôme Chave; David A. Coomes; John Caspersen; Arshad Ali; Grace Jopaul Loubota Panzou; Ted R. Feldpausch; Daniel Falster; Vladimir A. Usoltsev; Stephen Adu‐Bredu; Luciana F. Alves; et al. (Global Change Biology, 2022)
Data capturing multiple axes of tree size and shape, such as a tree's stem diameter, height and crown size, underpin a wide range of ecological research—from developing and testing theory on forest structure and dynamics, to estimating forest carbon stocks and their uncertainties, and integrating remote sensing imagery into forest monitoring programmes. However, these data can be surprisingly hard to come by, particularly for certain regions of the world and for specific taxonomic groups, posing a real barrier to progress in these fields. To overcome this challenge, we developed the Tallo database, a collection of 498,838 georeferenced and taxonomically standardized records of individual trees for which stem diameter, height and/or crown radius have been measured. These data were collected at 61,856 globally distributed sites, spanning all major forested and non‐forested biomes. The majority of trees in the database are identified to species (88%), and collectively Tallo includes data for 5163 species distributed across 1453 genera and 187 plant families. The database is publicly archived under a CC‐BY 4.0 licence and can be access from: https://doi.org/10.5281/zenodo.6637599 . To demonstrate its value, here we present three case studies that highlight how the Tallo database can be used to address a range of theoretical and applied questions in ecology—from testing the predictions of metabolic scaling theory, to exploring the limits of tree allometric plasticity along environmental gradients and modelling global variation in maximum attainable tree height. In doing so, we provide a key resource for field ecologists, remote sensing researchers and the modelling community working together to better understand the role that trees play in regulating the terrestrial carbon cycle.

Glucose metabolism patterns: A potential index to characterize brain ageing and predict high conversion risk into cognitive impairment - Jiehui Jiang; Can Sheng; Guanqun Chen; Chunhua Liu; Shichen Jin; Lanlan Li; Xueyan Jiang; Ying Han; Michael W. Weiner; Paul Aisen; Ronald Petersen; Clifford R. Jack; et al. (GeroScience, 2022)

Comparing the Pb(II) binding with different fluorescent components of dissolved organic matter from typical sources - Fang Liu; Wan-E Zhuang; Liyang Yang (Environmental Science and Pollution Research, 2022)

Assessing the joint effects of brain aging and gut microbiota on the risks of psychiatric disorders - Huijie Zhang; Li Liu; Shiqiang Cheng; Yumeng Jia; Yan Wen; Xuena Yang; Peilin Meng; Chun’e Li; Chuyu Pan; Yujing Chen; Zhen Zhang; Jingxi Zhang; et al. (Brain Imaging and Behavior, 2022)

Electrospun nanofibers food packaging: trends and applications in food systems - Dur E. Sameen; Saeed Ahmed; Rui Lu; Rui Li; Jianwu Dai; Wen Qin; Qing Zhang; Suqing Li; Yaowen Liu (Critical Reviews in Food Science and Nutrition, 2022)

Spatial Ecology of Atlantic Halibut across the Northwest Atlantic: A Recovering Species in an Era of Climate Change - Nancy L. Shackell; Jonathan A. D. Fisher; Cornelia E. den Heyer; Daniel R. Hennen; Andrew C. Seitz; Arnault Le Bris; Dominique Robert; Michael E. Kersula; Steven X. Cadrin; Richard S. McBride; Christopher H. McGuire; Tony Kess; et al. (Reviews in Fisheries Science & Aquaculture, 2022)

Semi-synthesis and cytotoxicity evaluation of pyrimidine, thiazole, and indole analogues of argentatins A–C from guayule (Parthenium argentatum) resin - Chandrashekhar Madasu; Ya-Ming Xu; E. M. Kithsiri Wijeratne; Manping X. Liu; István Molnár; A. A. Leslie Gunatilaka (Medicinal Chemistry Research, 2022)

Potassium phosphite enhanced the suppressive capacity of the soil microbiome against the tomato pathogen Ralstonia solanacearum - Lv Su; Haichao Feng; Xingxia Mo; Juan Sun; Pengfei Qiu; Yunpeng Liu; Ruifu Zhang; Eiko E. Kuramae; Biao Shen; Qirong Shen (Biology and Fertility of Soils, 2022)

Evidence of interactions between sharks and Indo‐Pacific humpback dolphins ( Sousa chinensis ) in the northern South China Sea - Agathe Serres; Wenzhi Lin; Eric E. G. Clua; Mingli Lin; Mingming Liu; Songhai Li (Marine Mammal Science, 2022)

Re‐description of the loach species Homatula variegata (Dabry de Thiersant, 1874) (Pisces: Nemacheilidae) from the middle Huang‐He basin in Shaanxi Province of Central China - Yi Liu; Liang Cao; E. Zhang (Journal of Fish Biology, 2022)
Despite the wide recognition of Homatula variegata (Dabry de Thiersant, 1874) as a valid Chinese loach, its type locality, identity and distribution still remain contentious. A molecular phylogenetic analysis based on the mitochondrial cytochrome b (cyt b) gene for samples from all known range of the species showed that three distinct species are involved. Morphological comparisons, coupled with examination on the types, confirmed that H. variegata s. str. is characterized by having a sparsely scaled predorsal body, an adipose crest along the dorsal midline of the caudal peduncle that extends forward to the vertical through the posterior end of the anal‐fin base and a broadly rounded caudal fin. It is found merely in the Wei‐He of the Huang‐He basin. The Jinsha‐Jiang population, previously misidentified as H. variegata , represents a distinct species, for which Homatula oxygnathra is the available name. Homatula laxiclathra , endemic to the Wei‐He, is also a valid species distinct from H. variegata .

Comprehensive analysis of epigenetic clocks reveals associations between disproportionate biological ageing and hippocampal volume - Lidija Milicic; Michael Vacher; Tenielle Porter; Vincent Doré; Samantha C. Burnham; Pierrick Bourgeat; Rosita Shishegar; James Doecke; Nicola J. Armstrong; Rick Tankard; Paul Maruff; Colin L. Masters; et al. (GeroScience, 2022)
The concept of age acceleration, the difference between biological age and chronological age, is of growing interest, particularly with respect to age-related disorders, such as Alzheimer’s Disease (AD). Whilst studies have reported associations with AD risk and related phenotypes, there remains a lack of consensus on these associations. Here we aimed to comprehensively investigate the relationship between five recognised measures of age acceleration, based on DNA methylation patterns (DNAm age), and cross-sectional and longitudinal cognition and AD-related neuroimaging phenotypes (volumetric MRI and Amyloid-β PET) in the Australian Imaging, Biomarkers and Lifestyle (AIBL) and the Alzheimer’s Disease Neuroimaging Initiative (ADNI). Significant associations were observed between age acceleration using the Hannum epigenetic clock and cross-sectional hippocampal volume in AIBL and replicated in ADNI. In AIBL, several other findings were observed cross-sectionally, including a significant association between hippocampal volume and the Hannum and Phenoage epigenetic clocks. Further, significant associations were also observed between hippocampal volume and the Zhang and Phenoage epigenetic clocks within Amyloid-β positive individuals. However, these were not validated within the ADNI cohort. No associations between age acceleration and other Alzheimer’s disease-related phenotypes, including measures of cognition or brain Amyloid-β burden, were observed, and there was no association with longitudinal change in any phenotype. This study presents a link between age acceleration, as determined using DNA methylation, and hippocampal volume that was statistically significant across two highly characterised cohorts. The results presented in this study contribute to a growing literature that supports the role of epigenetic modifications in ageing and AD-related phenotypes.

Prediction of disability-free survival in healthy older people - Johannes Tobias Neumann; Le T. P. Thao; Anne M. Murray; Emily Callander; Prudence R. Carr; Mark R. Nelson; Rory Wolfe; Robyn L. Woods; Christopher M. Reid; Raj C. Shah; Anne B. Newman; Jeff D. Williamson; et al. (GeroScience, 2022)
Prolonging survival in good health is a fundamental societal goal. However, the leading determinants of disability-free survival in healthy older people have not been well established. Data from ASPREE, a bi-national placebo-controlled trial of aspirin with 4.7 years median follow-up, was analysed. At enrolment, participants were healthy and without prior cardiovascular events, dementia or persistent physical disability. Disability-free survival outcome was defined as absence of dementia, persistent disability or death. Selection of potential predictors from amongst 25 biomedical, psychosocial and lifestyle variables including recognized geriatric risk factors, utilizing a machine-learning approach. Separate models were developed for men and women. The selected predictors were evaluated in a multivariable Cox proportional hazards model and validated internally by bootstrapping. We included 19,114 Australian and US participants aged ≥65 years (median 74 years, IQR 71.6–77.7). Common predictors of a worse prognosis in both sexes included higher age, lower Modified Mini-Mental State Examination score, lower gait speed, lower grip strength and abnormal (low or elevated) body mass index. Additional risk factors for men included current smoking, and abnormal eGFR. In women, diabetes and depression were additional predictors. The biased-corrected areas under the receiver operating characteristic curves for the final prognostic models at 5 years were 0.72 for men and 0.75 for women. Final models showed good calibration between the observed and predicted risks. We developed a prediction model in which age, cognitive function and gait speed were the strongest predictors of disability-free survival in healthy older people. Trial registration Clinicaltrials.gov (NCT01038583)

An adaptive data cleaning framework: a case study of the water quality monitoring system in China - Zeng Chen; Peng Jiang; Jun Liu; Song Zheng; Zhenyu Shan; Zhihua Li; Huan Xu; Igor V. Bychkov; Alexei E. Hmelnov (Hydrological Sciences Journal, 2022)

River Flood Susceptibility and Basin Maturity Analyzed Using a Coupled Approach of Geo-morphometric Parameters and SWAT Model - Shan-e-hyder Soomro; Caihong Hu; Muhammad Waseem Boota; Zubair Ahmed; Liu Chengshuai; Han Zhenyue; Li Xiang; Mairaj Hyder Alias Aamir Soomro (Water Resources Management, 2022)

Identification and fine mapping of a major QTL (qRtsc8-1) conferring resistance to maize tar spot complex and validation of production markers in breeding lines - Jiaojiao Ren; Penghao Wu; Gordon M. Huestis; Ao Zhang; Jingtao Qu; Yubo Liu; Hongjian Zheng; Amos E. Alakonya; Thanda Dhliwayo; Michael Olsen; Felix San Vicente; Boddupalli M. Prasanna; et al. (Theoretical and Applied Genetics, 2022)
Key message A major QTL of qRtsc8-1 conferring TSC resistance was identified and fine mapped to a 721 kb region on chromosome 8 at 81 Mb, and production markers were validated in breeding lines. Abstract Tar spot complex (TSC) is a major foliar disease of maize in many Central and Latin American countries and leads to severe yield loss. To dissect the genetic architecture of TSC resistance, a genome-wide association study (GWAS) panel and a bi-parental doubled haploid population were used for GWAS and selective genotyping analysis, respectively. A total of 115 SNPs in bin 8.03 were detected by GWAS and three QTL in bins 6.05, 6.07, and 8.03 were detected by selective genotyping. The major QTL qRtsc8-1 located in bin 8.03 was detected by both analyses, and it explained 14.97% of the phenotypic variance. To fine map qRtsc8-1, the recombinant-derived progeny test was implemented. Recombinations in each generation were backcrossed, and the backcross progenies were genotyped with Kompetitive Allele Specific PCR (KASP) markers and phenotyped for TSC resistance individually. The significant tests for comparing the TSC resistance between the two classes of progenies with and without resistant alleles were used for fine mapping. In BC 5 generation, qRtsc8-1 was fine mapped in an interval of ~ 721 kb flanked by markers of KASP81160138 and KASP81881276. In this interval, the candidate genes GRMZM2G063511 and GRMZM2G073884 were identified, which encode an integral membrane protein-like and a leucine-rich repeat receptor-like protein kinase, respectively. Both genes are involved in maize disease resistance responses. Two production markers KASP81160138 and KASP81160155 were verified in 471 breeding lines. This study provides valuable information for cloning the resistance gene, and it will also facilitate the routine implementation of marker-assisted selection in the breeding pipeline for improving TSC resistance.

Effects of root density on soil detachment capacity by overland flow during one growing season - Junyang Liu; Zhengchao Zhou; Jun`e Liu; Xuemeng Su (Journal of Soils and Sediments, 2022)

Immunostimulatory effect of quaternary degree and acetyl group of quaternized chitosan on macrophages RAW 264.7 - Xiaomin Li; Rong’e Xing; Chaojie Xu; Song Liu; Yukun Qin; Kecheng Li; Huahua Yu; Pengcheng Li (Journal of Oceanology and Limnology, 2022)

Impact of land use on surface water quality: a case study of active agriculturally disturbed basin in China - L. Zhang; X. Liu; H. Wei; C. Yang; E. Li; Z. Wang (International Journal of Environmental Science and Technology, 2022)

Research progress on antimicrobial materials for food packaging - Saeed Ahmed; Dur E. Sameen; Rui Lu; Rui Li; Jianwu Dai; Wen Qin; Yaowen Liu (Critical Reviews in Food Science and Nutrition, 2022)

Active edible coatings and films with Mediterranean herbs to improve food shelf-life - Cristina Pérez-Santaescolástica; Paulo E. S. Munekata; Xi Feng; Ying Liu; Paulo Cezar Bastianello Campagnol; Jose M. Lorenzo (Critical Reviews in Food Science and Nutrition, 2022)

Sterols and triterpenoids from Ganoderma lucidum and their reversal activities of tumor multidrug resistance - Min Wu; Cui-e Shen; Qiao-fa Lin; Jin-yi Zhong; Yan-fei Zhou; Ben-chen Liu; Jian-hua Xu; Zhi-qiang Zhang; Peng Li (Natural Product Research, 2022)

Light at night disrupts biological clocks, calendars, and immune function - William H. Walker; Jacob R. Bumgarner; Darius D. Becker-Krail; Laura E. May; Jennifer A. Liu; Randy J. Nelson (Seminars in Immunopathology, 2022)

Optimal recycle price game theory model for second-hand mobile phone recycling - Kennedy E. Ehimwenma; Sujatha Krishnamoorthy; Zixuan Liu; Yang Qiu; Yihang Liu; Wangying Dou (Environmental Science and Pollution Research, 2022)

Impact of ambient temperature on life loss per death from cardiovascular diseases: a multicenter study in central China - Ling-Shuang Lv; Chun-Liang Zhou; Dong-Hui Jin; Wen-Jun Ma; Tao Liu; Yi-Jun Xie; Yi-Qing Xu; Xing-E Zhang (Environmental Science and Pollution Research, 2022)
Background In the context of global climate change, studies have focused on the ambient temperature and mortality of cardiovascular diseases (CVDs). However, little is known about the effect of ambient temperature on year of life lost (YLL), especially the life loss per death caused by ambient temperature. In this study, we aimed to assess the relationship between ambient temperature and life loss and estimate the impact of ambient temperature on life loss per death. Methods We collected daily time series of mortality and meteorological data from 70 locations in Hunan province, central China, in periods ranging from Jan. 1, 2013, to Dec. 31, 2017. Crude rates of YLL were calculated per 100,000 people per year (YLL/100,000 population) for each location. A distributed lag nonlinear model and multivariate meta-regression were used to estimate the associations between ambient temperature and YLL rates. Then, the average life loss per death attributable to ambient temperature was calculated. Results There were 711,484 CVD deaths recorded within the study period. The exposure-response curve between ambient temperature and YLL rates was inverted J or U-shaped. Relative to the minimum YLL rate temperature, the life loss risk of extreme cold temperature lasted for 10 to 12 days, whereas the risk of extreme hot temperature appeared immediately and lasted for 3 days. On average, the life loss per death attributable to non-optimum ambient temperatures was 1.89 (95% CI, 1.21-2.56) years. Life loss was mainly caused by cold temperature (1.13, 95% CI, 0.89‑1.37), particularly moderate cold (1.00, 95% CI, 0.78‑1.23). For demographic characteristics, the mean life loss per death was relatively higher for males (2.07, 95% CI, 1.44‑2.68) and younger populations (3.72, 95% CI, 2.06‑5.46) than for females (1.88, 95% CI, 1.21-2.57) and elderly people (1.69, 95% CI, 1.28-2.10), respectively. Conclusions We found that both cold and hot temperatures significantly aggravated premature death from CVDs. Our results indicated that the whole range of effects of ambient temperature on CVDs should be given attention.

A bi-scale assessing framework for aesthetic ecosystem services of villages in a world heritage site - Yin-ping Ding; Zhi-lin Liu; Yuan-mei Jiao; Qiu-e Xu; Kan-feng Zhang; Cheng-jing Liu; Fan Chen (Journal of Mountain Science, 2022)

Another Record: Ocean Warming Continues through 2021 despite La Niña Conditions - Lijing Cheng; John Abraham; Kevin E. Trenberth; John Fasullo; Tim Boyer; Michael E. Mann; Jiang Zhu; Fan Wang; Ricardo Locarnini; Yuanlong Li; Bin Zhang; Zhetao Tan; et al. (Advances in Atmospheric Sciences, 2022)
The increased concentration of greenhouse gases in the atmosphere from human activities traps heat within the climate system and increases ocean heat content (OHC). Here, we provide the first analysis of recent OHC changes through 2021 from two international groups. The world ocean, in 2021, was the hottest ever recorded by humans, and the 2021 annual OHC value is even higher than last year’s record value by 14 ± 11 ZJ (1 zetta J = 10 21 J) using the IAP/CAS dataset and by 16 ± 10 ZJ using NCEI/NOAA dataset. The long-term ocean warming is larger in the Atlantic and Southern Oceans than in other regions and is mainly attributed, via climate model simulations, to an increase in anthropogenic greenhouse gas concentrations. The year-to-year variation of OHC is primarily tied to the El Niño-Southern Oscillation (ENSO). In the seven maritime domains of the Indian, Tropical Atlantic, North Atlantic, Northwest Pacific, North Pacific, Southern oceans, and the Mediterranean Sea, robust warming is observed but with distinct inter-annual to decadal variability. Four out of seven domains showed record-high heat content in 2021. The anomalous global and regional ocean warming established in this study should be incorporated into climate risk assessments, adaptation, and mitigation.

Causal Evidence for a Role of Cerebellar Lobulus Simplex in Prefrontal-Hippocampal Interaction in Spatial Working Memory Decision-Making - Yu Liu; Samuel S. McAfee; Meike E. Van Der Heijden; Mukesh Dhamala; Roy V. Sillitoe; Detlef H. Heck (The Cerebellum, 2022)

Associational resistance to nematodes and its effects on interspecific interactions among grassland plants - Xiangyu Liu; Ciska Raaijmakers; Klaas Vrieling; Suzanne T. E. Lommen; T. Martijn Bezemer (Plant and Soil, 2022)

Antibiotics Alter Pocillopora Coral-Symbiodiniaceae-Bacteria Interactions and Cause Microbial Dysbiosis During Heat Stress - Michael T. Connelly; Crystal J. McRae; Pi-Jen Liu; Cecily E. Martin; Nikki Traylor-Knowles (Frontiers in Marine Science, 2022)
Symbioses between eukaryotes and their associated microbial communities are fundamental processes that affect organisms’ ecology and evolution. A unique example of this is reef-building corals that maintain symbiotic associations with dinoflagellate algae (Symbiodiniaceae) and bacteria that affect coral health through various mechanisms. However, little is understood about how coral-associated bacteria communities affect holobiont heat tolerance. In this study, we investigated these interactions in four Pocillopora coral colonies belonging to three cryptic species by subjecting fragments to treatments with antibiotics intended to suppress the normal bacteria community, followed by acute heat stress. Separate treatments with only antibiotics or heat stress were conducted to compare the effects of individual stressors on holobiont transcriptome responses and microbiome shifts. Across all Pocillopora species examined, combined antibiotics and heat stress treatment significantly altered coral-associated bacteria communities and caused major changes in both coral and Cladocopium algal symbiont gene expression. Individually, heat stress impaired Pocillopora protein translation and activated DNA repair processes, while antibiotics treatments caused downregulation of Pocillopora amino acid and inorganic ion transport and metabolism genes and Cladocopium photosynthesis genes. Combined antibiotics-heat stress treatments caused synergistic effects on Pocillopora and Cladocopium gene expression including enhanced expression of oxidative stress response genes, programed cell death pathways and proteolytic enzymes that indicate an exacerbated response to heat stress following bacteria community suppression. Collectively, these results provide further evidence that corals and their Symbiodiniaceae and bacteria communities engage in highly coordinated metabolic interactions that are crucial for coral holobiont health, homeostasis, and heat tolerance.

The Synergistic Impacts of Anthropogenic Stressors and COVID-19 on Aquaculture: A Current Global Perspective - G. Sarà; M. C. Mangano; M. Berlino; L. Corbari; M. Lucchese; G. Milisenda; S. Terzo; M. S. Azaza; J. M. F. Babarro; R. Bakiu; B. R. Broitman; A. H. Buschmann; et al. (Reviews in Fisheries Science & Aquaculture, 2022)

Anti-drug Antibody Validation Testing and Reporting Harmonization - Heather Myler; João Pedras-Vasconcelos; Kelli Phillips; Charles Scott Hottenstein; Paul Chamberlain; Viswanath Devanaryan; Carol Gleason; Joanne Goodman; Marta Starcevic Manning; Shobha Purushothama; Susan Richards; Honglue Shen; et al. (The AAPS Journal, 2022)
Evolving immunogenicity assay performance expectations and a lack of harmonized anti-drug antibody validation testing and reporting tools have resulted in significant time spent by health authorities and sponsors on resolving filing queries. Following debate at the American Association of Pharmaceutical Sciences National Biotechnology Conference, a group was formed to address these gaps. Over the last 3 years, 44 members from 29 organizations (including 5 members from Europe and 10 members from FDA) discussed gaps in understanding immunogenicity assay requirements and have developed harmonization tools for use by industry scientists to facilitate filings to health authorities. Herein, this team provides testing and reporting strategies and tools for the following assessments: (1) pre-study validation cut point; (2) in-study cut points, including procedures for applying cut points to mixed populations; (3) system suitability control criteria for in-study plate acceptance; (4) assay sensitivity, including the selection of an appropriate low positive control; (5) specificity, including drug and target tolerance; (6) sample stability that reflects sample storage and handling conditions; (7) assay selectivity to matrix components, including hemolytic, lipemic, and disease state matrices; (8) domain specificity for multi-domain therapeutics; (9) and minimum required dilution and extraction-based sample processing for titer reporting. Graphical Abstract

Circular RNA screening identifies circMYLK4 as a regulator of fast/slow myofibers in porcine skeletal muscles - Haigang Cao; Jieming Liu; Tianning Du; Yihao Liu; Xiaoyu Zhang; Yuan Guo; Jie Wang; Xiaomin Zhou; Xiao Li; Gongshe Yang; Xin’e Shi (Molecular Genetics and Genomics, 2022)
The type of myofiber is related to the quality of meat. The slow oxidized myofiber helps to increase the tenderness and juiciness of muscle. Numerous studies have shown that circRNA plays a key role in skeletal muscle development. However, the role of circRNA in porcine skeletal myofiber types is unclear. In this study, we performed high-throughput RNA sequencing to study the differential expression of circRNA in the longissimus dorsi and the soleus muscle. A total of 40,757 circRNAs were identified, of which 181 were significantly different. Interestingly, some circRNAs were involved in metabolism pathways, AMPK, FoxO, and PI3K-Akt signaling pathways. Besides, we focused on a novel circRNA-circMYLK4. By injecting circMYLK4-AAV into piglets, we found that circMYLK4 significantly increased the mRNA and protein levels of the slow muscle marker genes. In summary, our study laid an essential foundation for further research of circRNA in myofiber type conversion and higher meat quality.

Tolypocladium reniformisporum sp. nov. and Tolypocladium cylindrosporum (Ophiocordycipitaceae, Hypocreales) co-occurring on Ophiocordyceps sinensis - Yao Wang; Yan-Fang Liu; De-Xiang Tang; Yuan-Bing Wang; Alison E. M. Adams; Hong Yu (Mycological Progress, 2022)

Genome-wide analysis of mitochondrial DNA copy number reveals loci implicated in nucleotide metabolism, platelet activation, and megakaryocyte proliferation - R. J. Longchamps; S. Y. Yang; C. A. Castellani; W. Shi; J. Lane; M. L. Grove; T. M. Bartz; C. Sarnowski; C. Liu; K. Burrows; A. L. Guyatt; T. R. Gaunt; et al. (Human Genetics, 2022)
Mitochondrial DNA copy number (mtDNA-CN) measured from blood specimens is a minimally invasive marker of mitochondrial function that exhibits both inter-individual and intercellular variation. To identify genes involved in regulating mitochondrial function, we performed a genome-wide association study (GWAS) in 465,809 White individuals from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium and the UK Biobank (UKB). We identified 133 SNPs with statistically significant, independent effects associated with mtDNA-CN across 100 loci. A combination of fine-mapping, variant annotation, and co-localization analyses was used to prioritize genes within each of the 133 independent sites. Putative causal genes were enriched for known mitochondrial DNA depletion syndromes ( p = 3.09 × 10 –15 ) and the gene ontology (GO) terms for mtDNA metabolism ( p = 1.43 × 10 –8 ) and mtDNA replication ( p = 1.2 × 10 –7 ). A clustering approach leveraged pleiotropy between mtDNA-CN associated SNPs and 41 mtDNA-CN associated phenotypes to identify functional domains, revealing three distinct groups, including platelet activation, megakaryocyte proliferation, and mtDNA metabolism. Finally, using mitochondrial SNPs, we establish causal relationships between mitochondrial function and a variety of blood cell-related traits, kidney function, liver function and overall ( p = 0.044) and non-cancer mortality ( p = 6.56 × 10 –4 ).

Evaluation of pharmacogenomics and hepatic nuclear imaging–related covariates by population pharmacokinetic models of irinotecan and its metabolites - Zheng Liu; Jennifer H. Martin; Winston Liauw; Sue-Anne McLachlan; Emma Link; Anetta Matera; Michael Thompson; Michael Jefford; Rod J. Hicks; Carleen Cullinane; Athena Hatzimihalis; Ian Campbell; et al. (European Journal of Clinical Pharmacology, 2022)

Characterizing unforced decadal climate variability in global climate model large ensembles - Bin Yao; Yangyang Xu; Andrew E. Dessler; Chao Liu (Climate Dynamics, 2022)

Integer ambiguity resolution and precise positioning for tight integration of BDS-3, GPS, GALILEO, and QZSS overlapping frequencies signals - Guang’e Chen; Bofeng Li; Zhiteng Zhang; Tianxia Liu (GPS Solutions, 2022)

Underground pumped hydroelectric schemes: the Madeira Island case - Luis Ribeiro e Sousa; Liu Gouzhao; Paulo Cafofo; Rita Leal Sousa; António Topa Gomes; Daniel Dias; Eurípedes Vargas (Arabian Journal of Geosciences, 2022)

Bmi1 Regulates Wnt Signaling in Hematopoietic Stem and Progenitor Cells - Hao Yu; Rui Gao; Sisi Chen; Xicheng Liu; Qiang Wang; Wenjie Cai; Sasidhar Vemula; Aidan C. Fahey; Danielle Henley; Michihiro Kobayashi; Stephen Z. Liu; Zhijian Qian; et al. (Stem Cell Reviews and Reports, 2021)

Effect of Biochar on Urea Hydrolysis Rate and Soil ureC Gene Copy Numbers - Zunqi Liu; Yang E; Yu Lan; Tianyi He; Wenfu Chen; Jun Meng (Journal of Soil Science and Plant Nutrition, 2021)

Chlorogenic acid inhibits apoptosis in thiram-induced tibial dyschondroplasia via intrinsic pathway - Jialu Zhang; Bihao Luo; Juanjuan Liu; Muhammad Waqas; Muhammad Fakhar-e-Alam Kulyar; Kangkang Guo; Jiakui Li (Environmental Science and Pollution Research, 2021)

Data-driven modelling techniques for earth-air heat exchangers to reduce energy consumption in buildings: a review - Shams Forruque Ahmed; Suvash C. Saha; J. C. Debnath; G. Liu; M. Mofijur; Ali Baniyounes; S. M. E. K. Chowdhury; Dai-Viet N. Vo (Environmental Chemistry Letters, 2021)

Correction to: 2021 Taxonomic update of phylum Negarnaviricota (Riboviria: Orthornavirae), including the large orders Bunyavirales and Mononegavirales - Jens H. Kuhn; Scott Adkins; Bernard R. Agwanda; Rim Al Kubrusli; Sergey V. Alkhovsky; Gaya K. Amarasinghe; Tatjana Avšič-Županc; María A. Ayllón; Justin Bahl; Anne Balkema-Buschmann; Matthew J. Ballinger; Christopher F. Basler; et al. (Archives of Virology, 2021)

2021 Taxonomic update of phylum Negarnaviricota (Riboviria: Orthornavirae), including the large orders Bunyavirales and Mononegavirales - Jens H. Kuhn; Scott Adkins; Bernard R. Agwanda; Rim Al Kubrusli; Sergey V. Alkhovsky; Gaya K. Amarasinghe; Tatjana Avšič-Županc; María A. Ayllón; Justin Bahl; Anne Balkema-Buschmann; Matthew J. Ballinger; Christopher F. Basler; et al. (Archives of Virology, 2021)

Virus infection modulates male sexual behaviour in Caenorhabditis elegans - Lisa van Sluijs; Jie Liu; Mels Schrama; Sanne van Hamond; Sophie P. J. M. Vromans; Marèl H. Scholten; Nika Žibrat; Joost A. G. Riksen; Gorben P. Pijlman; Mark G. Sterken; Jan E. Kammenga (Molecular Ecology, 2021)
Mating dynamics follow from natural selection on mate choice and individuals maximizing their reproductive success. Mate discrimination reveals itself by a plethora of behaviours and morphological characteristics, each of which can be affected by pathogens. A key question is how pathogens affect mate choice and outcrossing behaviour. Here we investigated the effect of Orsay virus on the mating dynamics of the androdiecious (male and hermaphrodite) nematode Caenorhabditis elegans . We tested genetically distinct strains and found that viral susceptibility differed between sexes in a genotype‐dependent manner with males of reference strain N2 being more resistant than hermaphrodites. Males displayed a constitutively higher expression of intracellular pathogen response (IPR) genes, whereas the antiviral RNAi response did not have increased activity in males. Subsequent monitoring of sex ratios over 10 generations revealed that viral presence can change mating dynamics in isogenic populations. Sexual attraction assays showed that males preferred mating with uninfected rather than infected hermaphrodites. Together our results illustrate for the first time that viral infection can significantly affect male mating choice and suggest altered mating dynamics as a novel cause benefitting outcrossing under pathogenic stress conditions in C . elegans .

Assessing the population‐level conservation effects of marine protected areas - Daniel Ovando; Jennifer E. Caselle; Christopher Costello; Olivier Deschenes; Steven D. Gaines; Ray Hilborn; Owen Liu (Conservation Biology, 2021)
Marine protected areas (MPAs) cover 3–7% of the world's ocean, and international organizations call for 30% coverage by 2030. Although numerous studies show that MPAs produce conservation benefits inside their borders, many MPAs are also justified on the grounds that they confer conservation benefits to the connected populations that span beyond their borders. A network of MPAs covering roughly 20% of the Channel Islands National Marine Sanctuary was established in 2003, with a goal of providing regional conservation and fishery benefits. We used a spatially explicit bioeconomic simulation model and a Bayesian difference‐in‐difference regression to examine the conditions under which MPAs can provide population‐level conservation benefits inside and outside their borders and to assess evidence of those benefits in the Channel Islands. As of 2017, we estimated that biomass densities of targeted fin‐fish had a median value 81% higher (90% credible interval: 23–148) inside the Channel Island MPAs than outside. However, we found no clear effect of these MPAs on mean total biomass densities at the population level: estimated median effect was –7% (90% credible interval: –31 to 23) from 2015 to 2017. Our simulation model showed that effect sizes of MPAs of

Sequestration and Cyanobacterial Diet Preferences in the Opisthobranch Molluscs Dolabrifera nicaraguana and Stylocheilus rickettsi - Kasey E. Clark; Angela Capper; Wei-Ting Liu; Amanda M. Fenner; Alejandro Almanza; Gina Della Togna; Liuris Herrera; Timothy Johns; Valerie J. Paul; Pieter C. Dorrestein; Todd L. Capson; Marcy J. Balunas (Frontiers in Marine Science, 2021)
A multidisciplinary approach was used to assess chemical ecological dietary interactions between marine organisms as a tool to isolate novel ecologically relevant compounds with biotechnological potential. First, laboratory-based feeding preference assays of the sea hare Dolabrifera nicaraguana (previously known as D. dolabrifera ), an anaspidean mollusc, were conducted by simultaneously offering six food options collected from nearby tidal pools in the Coiba National Park in the Tropical Eastern Pacific of Panama. An evaluation of preferred dietary repertoire revealed D. nicaraguana significantly preferred cf. Lyngbya sp. over the cyanobacterium Symploca sp., green alga Chaetomorpha sp., and red alga Spyridia sp. A no-choice feeding assay using cf. Lyngbya sp. or green alga Cladophora sp. supported this finding. Secondly, we conducted bioactivity-guided fractionation using the preferred food source of D. nicaraguana , the ‘hair-like” cf. Lyngbya sp. from which we also isolated and elucidated two new depsipeptide compounds, veraguamide M ( 1 ) and veraguamide N ( 2 ). Veraguamides M ( 1 ) and N ( 2 ) showed in vitro activity toward the malaria-causing parasite Plasmodium falciparum with GI 50 values of 4.2 and 4.3 μM, respectively, and therapeutic windows of 7.0–8.0 (based on moderate cytotoxicities to mammalian Vero cells with GI 50 values of 29.3 and 34.1 μM, respectively). Veraguamide N ( 2 ) was also active against Leishmania donovani , the causative agent of visceral leishmaniasis, with a GI 50 value of 6.9 μM. We then evaluated sequestration of these new compounds by D. nicaraguana used in the feeding assays and found trace amounts of the dietary sequestered compounds. Finally, we evaluated sequestration of these new compounds by the sea hare Stylocheilus rickettsi (previously known as S. striatus ) that were grazing on the cf. Lyngbya sp. used in the feeding assays and found both to be sequestered. This study is the first example whereby compounds with significant activity against tropical parasites have been found in both the sea hare S. rickettsi and its cyanobacterial food source. These results suggest that chemical ecological studies involving sea hares and cyanobacteria continue to provide a diverse source of bioactive compounds with biotechnological potential.

Dolutegravir Inhibition of Matrix Metalloproteinases Affects Mouse Neurodevelopment - Aditya N. Bade; JoEllyn M. McMillan; Yutong Liu; Benson J. Edagwa; Howard E. Gendelman (Molecular Neurobiology, 2021)
Dolutegravir (DTG) is a first-line antiretroviral drug (ARV) used in combination therapy for the treatment of human immunodeficiency virus type-1 (HIV-1) infection. The drug is effective, safe, and well tolerated. Nonetheless, concerns have recently emerged for its usage in pregnant women or those of child-bearing age. Notably, DTG-based ARV regimens have been linked to birth defects seen as a consequence of periconceptional usages. To this end, uncovering an underlying mechanism for DTG-associated adverse fetal development outcomes has gained clinical and basic research interest. We now report that DTG inhibits matrix metalloproteinases (MMPs) activities that could affect fetal neurodevelopment. DTG is a broad-spectrum MMPs inhibitor and binds to Zn ++ at the enzyme’s catalytic domain. Studies performed in pregnant mice show that DTG readily reaches the fetal central nervous system during gestation and inhibits MMP activity. Postnatal screenings of brain health in mice pups identified neuroinflammation and neuronal impairment. These abnormalities persist as a consequence of in utero DTG exposure. We conclude that DTG inhibition of MMPs activities during gestation has the potential to affect prenatal and postnatal neurodevelopment.

A 168-year temperature recording based on tree rings and latitude differences in temperature changes in northeast China - Yangao Jiang; Yuting Cao; Junhui Zhang; Zhuo Li; Guoqiang Shi; Shijie Han; Cassius E. O. Coombs; Chuan Liu; Xiaoguang Wang; Junwei Wang; Lin Hao; Qi Xu; et al. (International Journal of Biometeorology, 2021)

Emergy-based ecological efficiency evaluation and optimization method for logistics park - Cui Wang; Cuixia Zhang; Fagang Hu; Yuan Wang; Li’e Yu; Conghu Liu (Environmental Science and Pollution Research, 2021)

Bacterial Viruses Subcommittee and Archaeal Viruses Subcommittee of the ICTV: update of taxonomy changes in 2021 - Mart Krupovic; Dann Turner; Vera Morozova; Mike Dyall-Smith; Hanna M. Oksanen; Rob Edwards; Bas E. Dutilh; Susan M. Lehman; Alejandro Reyes; Diana P. Baquero; Matthew B. Sullivan; Jumpei Uchiyama; et al. (Archives of Virology, 2021)
In this article, we – the Bacterial Viruses Subcommittee and the Archaeal Viruses Subcommittee of the International Committee on Taxonomy of Viruses (ICTV) – summarise the results of our activities for the period March 2020 – March 2021. We report the division of the former Bacterial and Archaeal Viruses Subcommittee in two separate Subcommittees, welcome new members, a new Subcommittee Chair and Vice Chair, and give an overview of the new taxa that were proposed in 2020, approved by the Executive Committee and ratified by vote in 2021. In particular, a new realm, three orders, 15 families, 31 subfamilies, 734 genera and 1845 species were newly created or redefined (moved/promoted).

Overcoming the acquired resistance to gefitinib in lung cancer brain metastasis in vitro and in vivo - Zhongwei Liu; Neal Shah; Kent L. Marshall; Samuel A. Sprowls; Pushkar Saralkar; Afroz Mohammad; Kathryn E. Blethen; Tasneem A. Arsiwala; Ross Fladeland; Paul R. Lockman; Weimin Gao (Archives of Toxicology, 2021)

Changes in the chemical composition of the organic carbon in Spartina alterniflora litter during decomposition in saltmarsh sediments - Jin-e Liu; Zihao Shu; Yan-ping Zhao; Dailan Deng; Caiyu Zou; Yue Xin; Limin Zhang (Journal of Soils and Sediments, 2021)

Spartina alterniflora saltmarsh soil organic carbon properties and sources in coastal wetlands - Jin-e Liu; Dailan Deng; Caiyu Zou; Ruiming Han; Yue Xin; Zihao Shu; Li-min Zhang (Journal of Soils and Sediments, 2021)

Evaluation of dsRNA delivery methods for targeting macrophage migration inhibitory factor MIF in RNAi-based aphid control - Shaoshuai Liu; Maria Jose Ladera-Carmona; Minna M. Poranen; Aart J. E. van Bel; Karl-Heinz Kogel; Jafargholi Imani (Journal of Plant Diseases and Protection, 2021)
Macrophage migration inhibitory factors (MIFs) are multifunctional proteins regulating major processes in mammals, including activation of innate immune responses. In invertebrates, MIF proteins participate in the modulation of host immune responses when secreted by parasitic organisms, such as aphids. In this study, we assessed the possibility to use MIF genes as targets for RNA interference (RNAi)-based control of the grain aphid Sitobion avenae ( Sa ) on barley ( Hordeum vulgare ). When nymphs were fed on artificial diet containing double-stranded (ds)RNAs ( SaMIF -dsRNAs) that target sequences of the three MIF genes SaMIF1 , SaMIF2 and SaMIF3 , they showed higher mortality rates and these rates correlated with reduced MIF transcript levels as compared to the aphids feeding on artificial diet containing a control dsRNA ( GFP -dsRNA). Comparison of different feeding strategies showed that nymphs’ survival was not altered when they fed from barley seedlings sprayed with naked SaMIF -dsRNAs, suggesting they did not effectively take up dsRNA from the sieve tubes of these plants. Furthermore, aphids’ survival was also not affected when the nymphs fed on leaves supplied with dsRNA via basal cut ends of barley leaves. Consistent with this finding, the use of sieve tube-specific YFP-labeled Arabidopsis reporter lines confirmed that fluorescent 21 nt dsRNA Cy3 , when supplied via petioles or spraying, co-localized with xylem structures, but not with phloem tissue. Our results suggest that MIF genes are a potential target for insect control and also imply that application of naked dsRNA to plants for aphid control is inefficient. More efforts should be put into the development of effective dsRNA formulations.

The Toxicology Investigators Consortium 2020 Annual Report - Meghan B. Spyres; Kim Aldy; Lynn A Farrugia; A. Min Kang; Jennifer S. Love; Sharan L. Campleman; Shao Li; Alexandra Amaducci; Evan Schwarz; Paul M. Wax; Jeffery Brent; J. Acciani; et al. (Journal of Medical Toxicology, 2021)

sPlotOpen – An environmentally balanced, open‐access, global dataset of vegetation plots - Francesco Maria Sabatini; Jonathan Lenoir; Tarek Hattab; Elise Aimee Arnst; Milan Chytrý; Jürgen Dengler; Patrice De Ruffray; Stephan M. Hennekens; Ute Jandt; Florian Jansen; Borja Jiménez‐Alfaro; Jens Kattge; et al. (Global Ecology and Biogeography, 2021)
Motivation Assessing biodiversity status and trends in plant communities is critical for understanding, quantifying and predicting the effects of global change on ecosystems. Vegetation plots record the occurrence or abundance of all plant species co‐occurring within delimited local areas. This allows species absences to be inferred, information seldom provided by existing global plant datasets. Although many vegetation plots have been recorded, most are not available to the global research community. A recent initiative, called ‘sPlot’, compiled the first global vegetation plot database, and continues to grow and curate it. The sPlot database, however, is extremely unbalanced spatially and environmentally, and is not open‐access. Here, we address both these issues by (a) resampling the vegetation plots using several environmental variables as sampling strata and (b) securing permission from data holders of 105 local‐to‐regional datasets to openly release data. We thus present sPlotOpen, the largest open‐access dataset of vegetation plots ever released. sPlotOpen can be used to explore global diversity at the plant community level, as ground truth data in remote sensing applications, or as a baseline for biodiversity monitoring. Main types of variable contained Vegetation plots ( n = 95,104) recording cover or abundance of naturally co‐occurring vascular plant species within delimited areas. sPlotOpen contains three partially overlapping resampled datasets ( c . 50,000 plots each), to be used as replicates in global analyses. Besides geographical location, date, plot size, biome, elevation, slope, aspect, vegetation type, naturalness, coverage of various vegetation layers, and source dataset, plot‐level data also include community‐weighted means and variances of 18 plant functional traits from the TRY Plant Trait Database. Spatial location and grain Global, 0.01–40,000 m². Time period and grain 1888–2015, recording dates. Major taxa and level of measurement 42,677 vascular plant taxa, plot‐level records. Software format Three main matrices (.csv), relationally linked.

Design, Development, In Vitro and Preliminary In Vivo Evaluation of a Novel Photo-Angioplasty Device: Lumi-Solve - HongBin Liu; Gopal R. Sama; Andrea Robinson; Simon Mountford; Philip E. Thompson; Andrew Rodda; John Forsythe; Patrick J. Mornane; Paul Pasic; Helmut Thissen; Melissa Byrne; David M. Kaye; et al. (Cardiovascular Engineering and Technology, 2021)

Lower cardiac output is associated with neurodegeneration among older adults with normal cognition but not mild cognitive impairment - Elizabeth E. Moore; Dandan Liu; Corey W. Bown; Hailey A. Kresge; Deepak K. Gupta; Kimberly R. Pechman; Lisa A. Mendes; L. Taylor Davis; Katherine A. Gifford; Adam W. Anderson; Thomas J. Wang; Bennett A. Landman; et al. (Brain Imaging and Behavior, 2021)

Loss of endothelial glucocorticoid receptor promotes angiogenesis via upregulation of Wnt/β-catenin pathway - Bing Liu; Han Zhou; Tiening Zhang; Xixiang Gao; Bo Tao; Hao Xing; Zhenwu Zhuang; Alan Dardik; Themis R. Kyriakides; Julie E. Goodwin (Angiogenesis, 2021)
Objective The glucocorticoid receptor (GR) is a member of the nuclear receptor family that controls key biological processes in the cardiovascular system and has recently been shown to modulate Wnt signaling in endothelial cells. Wnt/β-catenin signaling has been demonstrated to be crucial in the process of angiogenesis. In the current study, we studied whether GR could regulate angiogenesis via the Wnt/β-catenin pathway. Approach and Resultsa Key components of the Wnt/β-catenin pathway were evaluated using quantitative PCR and Western blot in the presence or absence of GR. Enhanced angiogenesis was found in GR deficiency in vitro and confirmed with cell viability assays, proliferation assays and tube formation assays. Consistent with these in vitro findings, endothelial cell-specific GR loss GR in vivo promoted angiogenesis in both a hind limb ischemia model and sponge implantation assay. Results were further verified in a novel mouse model lacking endothelial LRP5/6, a key receptor in canonical Wnt signaling, and showed substantially suppressed angiogenesis using these same in vitro and in vivo assays. To further investigate the mechanism of GR regulation of Wnt signaling, autophagy flux was investigated in endothelial cells by visualizing auto phagolysosomes as well as by assessing P62 degradation and LC3B conversion. Results indicated that potentiated autophagy flux participated in GR-Wnt regulation. Conclusions Lack of endothelial GR triggers autophagy flux, leads to activation of Wnt/β-catenin signaling and promotes angiogenesis. There may also be a synergistic interaction between autophagy and Wnt/β-catenin signaling.

Type of pulse crop included in a 2-year rotation with wheat affects total N2O loss and intensity - Liting Liu; J. Diane Knight; Reynald L. Lemke; Richard E. Farrell (Biology and Fertility of Soils, 2021)

The interplay between ABA/ethylene and NAC TFs in tomato fruit ripening: a review - XiaoHong Kou; JiaQian Zhou; Cai E Wu; Sen Yang; YeFang Liu; LiPing Chai; ZhaoHui Xue (Plant Molecular Biology, 2021)

Correction to: The Case for a Critical Zone Science Approach to Research on Estuarine and Coastal Wetlands in the Anthropocene - Min Liu; Lijun Hou; Yi Yang; Limin Zhou; Michael E. Meadows (Estuaries and Coasts, 2021)
In the original version of the article Min Liu’s first and last names were transposed. It is correct as shown here.

The Case for a Critical Zone Science Approach to Research on Estuarine and Coastal Wetlands in the Anthropocene - Min Liu; Lijun Hou; Yi Yang; Limin Zhou; Michael E. Meadows (Estuaries and Coasts, 2021)
As the focus of land-sea interactions, estuarine and coastal ecosystems perform numerous vital ecological service functions, although they are highly vulnerable to various kinds of disturbance, both directly and indirectly related to human activity, that have attracted much recent attention. Critical zone science (CZS) has emerged as a valuable conceptual framework that focuses on quantitative interactions between diverse components of the environment and is able to integrate anthropogenic disturbance with a view to predicting future trajectories of change. However, coastal and estuarine environments appear to have been overlooked in CZS and are notably under-represented, indeed not explicitly represented at all, in the global network of critical zone observatories (CZOs). Even in the wider network of environmental observatories globally, estuarine and coastal wetland ecosystems are only very rarely an explicit focus. Further strengthening of integrated research in coastal and estuarine environments is required, more especially given the threats these ecosystems face due to growing population at the coast and against the background of climate change and sea level rise. The establishment of one or more CZOs, or their functional equivalents, with a strong focus on estuarine and coastal wetlands, should be urgently attended to.

Alzheimer’s disease pathology in a community-based sample of older adults without dementia: The MYHAT neuroimaging study - Kevin J. Sullivan; Anran Liu; Chung-Chou H. Chang; Ann D. Cohen; Brian J. Lopresti; Davneet S. Minhas; Charles M. Laymon; William E. Klunk; Howard Aizenstein; Neelesh K. Nadkarni; David Loewenstein; M. Ilyas Kamboh; et al. (Brain Imaging and Behavior, 2021)

Efficiency comparison of B6(Cg)-Tyrc−2j /J and C57BL/6NTac embryos as hosts for the generation of knockout mice - Yu’e Ma; Lei He; Lijie Xiang; Jie Zhang; Jing Wang; Wenjing Zhu; Wenni Cao; Yichen Zhu; Man Gao; Fei Zhou; Zhiwei Liu (Transgenic Research, 2021)
Careful selection of the host embryo is critical to the efficient production of knockout (KO) mice when injecting mouse embryonic stem (mES) cells into blastocysts. B6(Cg)-Tyr c−2j /J (B6 albino) and C57BL/6NTac (B6NTac) strains of mice are widely used to produce host blastocysts for such procedures. Here, we tested these two strains to identify an appropriate match for modified agouti C57BL/6N (JM8A3.N1) mES cells. When comparing blastocyst yield, super-ovulated B6NTac mice produced more injectable blastocysts per female than B6 albino mice (8.2 vs. 5.4). There was no significant difference in birth rate when injected embryos were transferred to the same pseudopregnant recipient strain. However, the live birth rate was significantly higher for B6NTac blastocysts than B6 albino blastocysts (62.7% vs. 50.2%). In addition, the proportion of pups exhibiting high-level and complete chimerism, as identified by coat color, was also significantly higher in the B6NTac strain. There was no obvious difference in the efficiency of germline transmission (GLT) when compared between B6NTac and B6 albino host embryos (61.5% vs. 63.3% for mES clones; 64.5% vs. 67.9% for genes, respectively), thus suggesting that an equivalent GLT rate could be obtained with only a few blastocyst injections for B6NTac embryos. In conclusion, our data indicate that B6NTac blastocysts are a better choice for the microinjection of JM8A3.N1 mES cells than B6 albino blastocysts.

Three novel transcription factors involved in cannabinoid biosynthesis in Cannabis sativa L. - Yuanyuan Liu; Panpan Zhu; Sen Cai; George Haughn; Jonathan E. Page (Plant Molecular Biology, 2021)

Isolation and identification of antimicrobial metabolites from sea anemone-derived fungus Emericella sp. SMA01 - Yang Yue; Huahua Yu; Rongfeng Li; Linfeng Hu; Song Liu; Rong’e Xing; Pengcheng Li (Journal of Oceanology and Limnology, 2021)

Soil engineering by ants facilitates plant compensation for large herbivore removal of aboveground biomass - Zhiwei Zhong; Xiaofei Li; Dirk Sanders; Yiming Liu; Ling Wang; Yvette K. Ortega; Dean E. Pearson; Deli Wang (Ecology, 2021)
The interplay between top‐down and bottom‐up processes determines ecosystem productivity. Yet, the factors that mediate the balance between these opposing forces remain poorly understood. Furthering this challenge, complex and often cryptic factors like ecosystem engineering and trait‐mediated interactions may play major roles in mediating the outcomes of top‐down and bottom‐up interactions. In semiarid grasslands of northeastern China, we conducted a large‐scale, three‐year experiment to evaluate how soil engineering by ants and plasticity in plants independently and jointly influenced the top‐down effects of grazing by a ubiquitous herbivore (cattle) on aboveground standing biomass of the dominant perennial grass, Leymus chinensis . Herbivory had strong top‐down effects, reducing L. chinensis AB by 25% relative to baseline levels without cattle or ants. In contrast, soil engineering by ants facilitated weak bottom‐up effects in the absence of herbivory. However, in the presence of herbivory, soil engineering effects were strong enough to fully offset herbivore removal of aboveground biomass. This outcome was mediated by L. chinensis ’s plasticity in reallocating growth from below‐ to aboveground biomass, a result linked to additive effects of engineers and herbivores increasing soil N availability and engineering effects improving soil structure. Soil engineering increased soil N by 12%, promoting aboveground biomass. Herbivores increased soil N by 13% via defecation, but this increase failed to offset their reductions in aboveground biomass in isolation. However, when combined, engineers and herbivores increased soil N by 26% and engineers improved soil bulk density, facilitating L. chinensis to shift resource allocations from below‐ to aboveground biomass sufficiently to fully offset herbivore suppression of aboveground biomass. Our results demonstrate that soil engineering and trait‐mediated effects of plant plasticity can strongly mediate the outcome of top‐down and bottom‐up interactions. These cryptic but perhaps ubiquitous processes may help to explain the long‐debated phenomenon of plant compensatory responses to large grazers.

The Kallianos Au-Ag-Te mineralization, Evia Island, Greece: a detachment-related distal hydrothermal deposit of the Attico-Cycladic Metallogenetic Massif - Stylianos F. Tombros; Sotirios Kokkalas; Karen St. Seymour; Panagiotis C. Voudouris; Anthony E. Williams-Jones; Degao Zhai; Jiajun Liu; Michalis G. Fitros (Mineralium Deposita, 2021)

Initial ingestion of CMV-infected plants reduces subsequent aphid performance - Xiao-bin Shi; Jun Deng; Zhuo Zhang; Shuo Yan; Li-min Zheng; Shu-e Sun; Yang Gao; Xu-guo Zhou; De-yong Zhang; Yong Liu (Arthropod-Plant Interactions, 2021)

Assessment of the impact of mitochondrial genotype upon drug-induced mitochondrial dysfunction in platelets derived from healthy volunteers - Amy L. Ball; Katarzyna M. Bloch; Lucille Rainbow; Xuan Liu; John Kenny; Jonathan J. Lyon; Richard Gregory; Ana Alfirevic; Amy E. Chadwick (Archives of Toxicology, 2021)
Mitochondrial DNA (mtDNA) is highly polymorphic and encodes 13 proteins which are critical to the production of ATP via oxidative phosphorylation. As mtDNA is maternally inherited and undergoes negligible recombination, acquired mutations have subdivided the human population into several discrete haplogroups. Mitochondrial haplogroup has been found to significantly alter mitochondrial function and impact susceptibility to adverse drug reactions. Despite these findings, there are currently limited models to assess the effect of mtDNA variation upon susceptibility to adverse drug reactions. Platelets offer a potential personalised model of this variation, as their anucleate nature offers a source of mtDNA without interference from the nuclear genome. This study, therefore, aimed to determine the effect of mtDNA variation upon mitochondrial function and drug-induced mitochondrial dysfunction in a platelet model. The mtDNA haplogroup of 383 healthy volunteers was determined using next-generation mtDNA sequencing (Illumina MiSeq). Subsequently, 30 of these volunteers from mitochondrial haplogroups H , J , T and U were recalled to donate fresh, whole blood from which platelets were isolated. Platelet mitochondrial function was tested at basal state and upon treatment with compounds associated with both mitochondrial dysfunction and adverse drug reactions, flutamide, 2-hydroxyflutamide and tolcapone (10–250 μM) using extracellular flux analysis. This study has demonstrated that freshly-isolated platelets are a practical, primary cell model, which is amenable to the study of drug-induced mitochondrial dysfunction. Specifically, platelets from donors of haplogroup J have been found to have increased susceptibility to the inhibition of complex I-driven respiration by 2-hydroxyflutamide. At a time when individual susceptibility to adverse drug reactions is not fully understood, this study provides evidence that inter-individual variation in mitochondrial genotype could be a factor in determining sensitivity to mitochondrial toxicants associated with costly adverse drug reactions.

Upper Ocean Temperatures Hit Record High in 2020 - Lijing Cheng; John Abraham; Kevin E. Trenberth; John Fasullo; Tim Boyer; Ricardo Locarnini; Bin Zhang; Fujiang Yu; Liying Wan; Xingrong Chen; Xiangzhou Song; Yulong Liu; et al. (Advances in Atmospheric Sciences, 2021)

Responses of submerged macrophytes and periphyton to warming under two nitrogen scenarios: A microcosm study - Yang Liu; Celina Aznarez; Erik Jeppesen; Hu He; Wei Li; Eti E. Levi; Juan Pablo Pacheco; Yu Cao (Hydrobiologia, 2021)

Regional Comparison of Snow Leopard (Panthera uncia) Diet using DNA Metabarcoding - Charlotte E. Hacker; Matthew Jevit; Shafqat Hussain; Ghulam Muhammad; Bariushaa Munkhtsog; Bayaraa Munkhtsog; Yuguang Zhang; Diqiang Li; Yanlin Liu; John D. Farrington; Farida Balbakova; Azat Alamanov; et al. (Biodiversity and Conservation, 2021)

Whole-cell bioreporters for evaluating petroleum hydrocarbon contamination - Bo Jiang; Yizhi Song; Zengjun Liu; Wei E. Huang; Guanghe Li; Songqiang Deng; Yi Xing; Dayi Zhang (Critical Reviews in Environmental Science and Technology, 2021)

Early-life cancer, infertility, and risk of adverse pregnancy outcomes: a registry linkage study in Massachusetts - Leslie V. Farland; Judy E. Stern; Sunah S. Hwang; Chia-ling Liu; Howard Cabral; Richard Knowlton; Susan T. Gershman; Charles C. Coddington; Stacey A. Missmer (Cancer Causes & Control, 2021)

Environmental microbiology in China - Wei E. Huang; Shuang‐Jiang Liu; Xiao‐Lei Wu; Yu‐Zhong Zhang; Fengping Wang (Environmental Microbiology, 2021)

Characteristics and mechanism of the landslide in Yongguang village, Minxian County, China - Qian Wang; Zhenming Wang; Yongqi Su; Xiumei Zhong; Lanmin Wang; Haiping Ma; Guoxing Zhang; Edward E. Woolery; Kun Liu (Natural Hazards, 2021)

High increase in biodegradability of coking wastewater enhanced by Mn ore tailings in Fenton/O3 combined processes - H. Liu; T. Xu; C. Li; W. Liu; E. Lichtfouse (International Journal of Environmental Science and Technology, 2021)

Tree ring width‐based January–March mean minimum temperature reconstruction from Larix gmelinii in the Greater Khingan Mountains, China since AD 1765 - Yangao Jiang; Chuan Liu; Junhui Zhang; Shijie Han; Cassius E. O. Coombs; Xiaoguang Wang; Junwei Wang; Lin Hao; Shengzhong Dong (International Journal of Climatology, 2021)
A ring‐width chronology of Larix gmelinii (LG) was developed in the northern Greater Khingan Mountains region of China. The response function analyses revealed that the local mean minimum temperature of January–March ( T 1–3 ) was the most limiting factor affecting the radial growth of LG trees. Based on correlation analysis, a reconstructed T 1–3 series from 1765 to 2013 was produced using standard ring‐width chronology. The reconstruction explained 41.2% of the total variance in recorded monthly mean minimum temperatures from 1960 to 2013. The reconstructed T 1–3 series had similar variability when compared with the May–September mean temperature reconstruction in Inner Mongolia (IM) and the February–March mean minimum temperature reconstruction in Yichun (YC). This reconstructed T 1–3 series also captured the severe snow disaster and cold wave events recorded from historical documents in Heilongjiang and Inner Mongolia. Spatial correlations between reconstructed series and gridded temperature data also provided a high level of confidence. In addition, significant relationships between the reconstructed T 1–3 series and the Pacific Decadal Oscillation (PDO), El Niño–Southern Oscillation (ENSO), North Atlantic Oscillation (NAO), solar activity, indicated that the T 1–3 variation might be influenced by large‐scale ocean–atmosphere interactions.

Fate of Hematopoiesis During Aging. What Do We Really Know, and What are its Implications? - Hal E. Broxmeyer; Yan Liu; Reuben Kapur; Christie M. Orschell; Arafat Aljoufi; James P. Ropa; Thao Trinh; Sarah Burns; Maegan L. Capitano (Stem Cell Reviews and Reports, 2020)

The effects of nicotine and cannabis co-use during adolescence and young adulthood on white matter cerebral blood flow estimates - Kelly E. Courtney; Rachel Baca; Neal Doran; Aaron Jacobson; Thomas T. Liu; Joanna Jacobus (Psychopharmacology, 2020)

Effects and Mechanism of Continuous Liming on Cadmium Immobilization and Uptake by Rice Grown on Acid Paddy Soils - Zhaobing Liu; Ying Huang; Xionghui Ji; Yunhe Xie; Jianwei Peng; Mamdouh A. Eissa; Ahmed E. Fahmy; Salah F. Abou-Elwafa (Journal of Soil Science and Plant Nutrition, 2020)

Knowledge of Cervical Cancer, Human Papilloma Virus (HPV) and HPV Vaccination Among Women in Northeast China - Yu-e Ning; Yao Liu; Xiao-yu Xu; Xin-yu Zhang; Ning Wang; Li-qiang Zheng (Journal of Cancer Education, 2020)
This study aimed to research the understanding and knowledge of cervical cancer, human papilloma virus (HPV), and HPV vaccination, and the acceptance of HPV vaccination, among a population of women in northeastern China. A cross-sectional survey was carried out by questionnaire to investigate knowledge of cervical cancer, HPV, and HPV vaccination. The 230 female participants were native residents of northeastern China, and their ages ranged between 18 and 65 years. Questionnaires were randomly acquired by the respondents from online and paper questionnaire distribution. The questionnaire included questions on three major aspects to record people’s perceptions of cervical cancer, HPV, and vaccines. Of the sample of 230 women surveyed, 80.9% had heard of cervical cancer, but understanding was only 15.7%; 38.3% knew about HPV; 20% knew about HPV vaccine; 39.6% agreed to receive HPV vaccination, and the remainder were mainly concerned about its safety and effectiveness. Data analysis showed that age, family income, and whether there was experience of screening all influenced knowledge of cervical cancer, but this was not statistically significant. The level of education had no obvious effect on the degree of knowledge about cervical cancer; however, with an improvement in education, women’s awareness of HPV vaccine improved significantly ( p < 0.05). Women who have received cervical cancer screening had significantly greater knowledge about cervical cancer and HPV than those with no screening ( p < 0.05). Women in northeastern China have little knowledge of cervical cancer, HPV, and HPV vaccine, lack disease knowledge, and hold a skeptical attitude about HPV vaccination. Medical institutions are the main channel providing information to these women.

Identifying the sources of seasonal predictability based on climate memory analysis and variance decomposition - Da Nian; Naiming Yuan; Kairan Ying; Ge Liu; Zuntao Fu; Yanjun Qi; Christian L. E. Franzke (Climate Dynamics, 2020)

Comparative performance assessment of landslide susceptibility models with presence-only, presence-absence, and pseudo-absence data - Dong-mei Zhao; Yuan-mei Jiao; Jin-liang Wang; Yin-ping Ding; Zhi-lin Liu; Cheng-jing Liu; Ying-mei Qiu; Juan Zhang; Qiu-e Xu; Chang-run Wu (Journal of Mountain Science, 2020)

SNP of AHSA2 gene in three cattle breeds using snapshot technology - Shu-Zhu Cheng; E. Guang-Xin; Cheng-Li Liu; Wang-Dui Basang; Yan-Bin Zhu; Ri-Su Na; Yan-Guo Han; Yan Zeng; Xiao Wang; Wei-Wei Ni; Bai-Gao Yang; Xing-Hai Duan; et al. (Journal of Genetics, 2020)

Migratory Zooplankton Excreta and Its Influence on Prokaryotic Communities - Amy E. Maas; Shuting Liu; Luis M. Bolaños; Brittany Widner; Rachel Parsons; Elizabeth B. Kujawinski; Leocadio Blanco-Bercial; Craig A. Carlson (Frontiers in Marine Science, 2020)
Particulate organic matter (POM) (fecal pellets) from zooplankton has been demonstrated to be an important nutrient source for the pelagic prokaryotic community. Significantly less is known about the chemical composition of the dissolved organic matter (DOM) produced by these eukaryotes and its influence on pelagic ecosystem structure. Zooplankton migrators, which daily transport surface-derived compounds to depth, may act as important vectors of limiting nutrients for mesopelagic microbial communities. In this role, zooplankton may increase the DOM remineralization rate by heterotrophic prokaryotes through the creation of nutrient rich “hot spots” that could potentially increase niche diversity. To explore these interactions, we collected the migratory copepod Pleuromamma xiphias from the northwestern Sargasso Sea and sampled its excreta after 12–16 h of incubation. We measured bulk dissolved organic carbon (DOC), dissolved free amino acids (DFAA) via high performance liquid chromatography and dissolved targeted metabolites via quantitative mass spectrometry (UPLC-ESI-MSMS) to quantify organic zooplankton excreta production and characterize its composition. We observed production of labile DOM, including amino acids, vitamins, and nucleosides. Additionally, we harvested a portion of the excreta and subsequently used it as the growth medium for mesopelagic (200 m) bacterioplankton dilution cultures. In zooplankton excreta treatments we observed a four-fold increase in bacterioplankton cell densities that reached stationary growth phase after five days of dark incubation. Analyses of 16S rRNA gene amplicons suggested a shift from oligotrophs typical of open ocean and mesopelagic prokaryotic communities to more copiotrophic bacterial lineages in the presence of zooplankton excreta. These results support the hypothesis that zooplankton and prokaryotes are engaged in complex and indirect ecological interactions, broadening our understanding of the microbial loop.

Correction: Impact of river reconstruction on groundwater flow during bank filtration assessed by transient three-dimensional modelling of flow and heat transport - Wei-shi Wang; Sascha E. Oswald; Thomas Gräff; Hermann-Josef Lensing; Tie Liu; Daniel Strasser; Matthias Munz (Hydrogeology Journal, 2020)

PSD-93 Interacts with SynGAP and Promotes SynGAP Ubiquitination and Ischemic Brain Injury in Mice - Qingxiu Zhang; Hui Yang; Hong Gao; Xiaomei Liu; Qingjie Li; Rong Rong; Zhenqian Liu; Xiu-e Wei; Liping Kong; Yun Xu; Liangqun Rong (Translational Stroke Research, 2020)

Joint Multi-modal Parcellation of the Human Striatum: Functions and Clinical Relevance - Xiaojin Liu; Simon B. Eickhoff; Felix Hoffstaedter; Sarah Genon; Svenja Caspers; Kathrin Reetz; Imis Dogan; Claudia R. Eickhoff; Ji Chen; Julian Caspers; Niels Reuter; Christian Mathys; et al. (Neuroscience Bulletin, 2020)

Experimental evidence for a protracted enrichment of tungsten in evolving granitic melts: implications for scheelite mineralization - Meng Wang; Jun Deng; Tong Hou; Insa T. Derrey; Roman E. Botcharnikov; Xi Liu; Chao Zhang; Dong-Mei Qi; Zhaochong Zhang; François Holtz (Mineralium Deposita, 2020)

Development of nuclear microsatellite markers to facilitate germplasm conservation and population genetics studies of five groups of tropical perennial plants with edible fruits and shoots: rambutan (Nephelium lappaceum L.), sapodilla (Manilkara zapota (L.) P. Royen), lychee (Litchi chinensis Sonn.), mangosteen (Garcinia mangostana Linn. and Garcinia cochinchinensis (Lour.) Choisy) and bamboo (Bambusa vulgaris Schrad. ex J.C. Wendl and Guadua angustifolia Kunth) - Renée S. Arias; Linda L. Ballard; Mary V. Duke; Sheron A. Simpson; Xiaofen F. Liu; Valerie A. Orner; Victor S. Sobolev; Brian E. Scheffler; Jaime Martinez-Castillo (Genetic Resources and Crop Evolution, 2020)

Seasonal Rainfall Forecasts for the Yangtze River Basin of China in Summer 2019 from an Improved Climate Service - Philip E. Bett; Nicola Martin; Adam A. Scaife; Nick Dunstone; Gill M. Martin; Nicola Golding; Joanne Camp; Peiqun Zhang; Chris D. Hewitt; Leon Hermanson; Chaofan Li; Hong-Li Ren; et al. (Journal of Meteorological Research, 2020)

Noise does not equal bias in assessing the evolutionary history of the angiosperm flora of China: A response to Qian (2019) - Li‐Min Lu; Hai‐Hua Hu; Dan‐Xiao Peng; Bing Liu; Jian‐Fei Ye; Tuo Yang; Hong‐Lei Li; Miao Sun; Stephen A. Smith; Pamela S. Soltis; Douglas E. Soltis; Zhi‐Duan Chen (Journal of Biogeography, 2020)
In response to our paper on the evolutionary history of the Chinese flora, Qian suggests that certain features of the divergence time estimation employed might have led to biased conclusions in Lu et al (2018). Here, we consider Qian's specific criticisms, explore the extent of uncertainty in the data and demonstrate that (i) no systematic bias toward dates that are too young or too old is detected in Lu et al.; (ii) constraint of the crown age of angiosperms does not bias the generic ages estimated by Lu et al.; and (iii) ages derived from the Chinese regional phylogeny do not bias the conclusions reported by Lu et al. All these analyses confirm that the conclusions reported previously are robust. We argue that, like many large‐scale biodiversity analyses, sources of noise in divergence time estimation are to be expected, but these should not be confused with bias.

Argo Data 1999–2019: Two Million Temperature-Salinity Profiles and Subsurface Velocity Observations From a Global Array of Profiling Floats - Annie P. S. Wong; Susan E. Wijffels; Stephen C. Riser; Sylvie Pouliquen; Shigeki Hosoda; Dean Roemmich; John Gilson; Gregory C. Johnson; Kim Martini; David J. Murphy; Megan Scanderbeg; T. V. S. Udaya Bhaskar; et al. (Frontiers in Marine Science, 2020)

Analytical and Computational Advances, Opportunities, and Challenges in Marine Organic Biogeochemistry in an Era of “Omics” - Andrew D. Steen; Stephanie Kusch; Hussain A. Abdulla; Nevenka Cakić; Sarah Coffinet; Thorsten Dittmar; James M. Fulton; Valier Galy; Kai-Uwe Hinrichs; Anitra E. Ingalls; Boris P. Koch; Elizabeth Kujawinski; et al. (Frontiers in Marine Science, 2020)

Knockouts of a late flowering gene via CRISPR–Cas9 confer early maturity in rice at multiple field locations - Guokui Wang; Changgui Wang; Guihua Lu; Wei Wang; Guanfan Mao; Jeffrey E. Habben; Chao Song; Jiantao Wang; Jian Chen; Yang Gao; Junhua Liu; Thomas W. Greene (Plant Molecular Biology, 2020)

Molecular characterization of gut microbial shift in SD rats after death for 30 days - Huan Li; E. Yang; Siruo Zhang; Jing Zhang; Lu Yuan; Ruina Liu; Shakir Ullah; Qi Wang; Nosheen Mushtaq; Yi Shi; Cuihong An; Zhenyuan Wang; et al. (Archives of Microbiology, 2020)

Drivers of future alien species impacts: An expert‐based assessment - Franz Essl; Bernd Lenzner; Sven Bacher; Sarah Bailey; Cesar Capinha; Curtis Daehler; Stefan Dullinger; Piero Genovesi; Cang Hui; Philip E. Hulme; Jonathan M. Jeschke; Stelios Katsanevakis; et al. (Global Change Biology, 2020)
Understanding the likely future impacts of biological invasions is crucial yet highly challenging given the multiple relevant environmental, socio‐economic and societal contexts and drivers. In the absence of quantitative models, methods based on expert knowledge are the best option for assessing future invasion trajectories. Here, we present an expert assessment of the drivers of potential alien species impacts under contrasting scenarios and socioecological contexts through the mid‐21st century. Based on responses from 36 experts in biological invasions, moderate (20%–30%) increases in invasions, compared to the current conditions, are expected to cause major impacts on biodiversity in most socioecological contexts. Three main drivers of biological invasions—transport, climate change and socio‐economic change—were predicted to significantly affect future impacts of alien species on biodiversity even under a best‐case scenario. Other drivers (e.g. human demography and migration in tropical and subtropical regions) were also of high importance in specific global contexts (e.g. for individual taxonomic groups or biomes). We show that some best‐case scenarios can substantially reduce potential future impacts of biological invasions. However, rapid and comprehensive actions are necessary to use this potential and achieve the goals of the Post‐2020 Framework of the Convention on Biological Diversity.

Effectiveness of beta blockers in patients with and without a history of myocardial infarction - Sanjay Verma; Edward L. Peterson; Bin Liu; Hani N. Sabbah; L. Keoki Williams; David E. Lanfear (European Journal of Clinical Pharmacology, 2020)

Identification by mass spectrometry and immunoblotting of xenogeneic antigens in the N- and O-glycomes of porcine, bovine and equine heart tissues - Chunsheng Jin; Reeja Maria Cherian; Jining Liu; Heribert Playà-Albinyana; Cesare Galli; Niclas G. Karlsson; Michael E. Breimer; Jan Holgersson (Glycoconjugate Journal, 2020)
Animal bioprosthetic heart valves (BHV) are used to replace defective valves in patients with valvular heart disease. Especially young BHV recipients may experience a structural valve deterioration caused by an immune reaction in which α-Gal and Neu5Gc are potential target antigens. The expression of these and other carbohydrate antigens in animal tissues used for production of BHV was explored. Protein lysates of porcine aortic and pulmonary valves, and porcine, bovine and equine pericardia were analyzed by Western blotting using anti-carbohydrate antibodies and lectins. N -glycans were released by PNGase F digestion and O -glycans by β-elimination. Released oligosaccharides were analyzed by liquid chromatography – tandem mass spectrometry. In total, 102 N -glycans and 40 O -glycans were identified in animal heart tissue lysates. The N - and O -glycan patterns were different between species. α-Gal and Neu5Gc were identified on both N - and O -linked glycans, N,N´ -diacetyllactosamine (LacdiNAc) on N -glycans only and sulfated O -glycans. The relative amounts of α-Gal-containing N -glycans were higher in bovine compared to equine and porcine pericardia. In contrast to the restricted number of proteins carrying α-Gal and LacdiNAc, the distribution of proteins carrying Neu5Gc-determinants varied between species and between different tissues of the same species. Porcine pericardium carried the highest level of Neu5Gc-sialylated O -glycans, and bovine pericardium the highest level of Neu5Gc-sialylated N -glycans. The identified N- and O- linked glycans, some of which may be immunogenic and remain in BHVs manufactured for clinical use, could direct future genetic engineering to prevent glycan expression rendering the donor tissues less immunogenic in humans.

Free fatty acid receptor 4 activation protects against choroidal neovascularization in mice - Yohei Tomita; Bertan Cakir; Chi-Hsiu Liu; Zhongjie Fu; Shuo Huang; Steve S. Cho; William R. Britton; Ye Sun; Mark Puder; Ann Hellström; Saswata Talukdar; Lois E. H. Smith (Angiogenesis, 2020)

Effect of Chinese Rice Wine on the Endogenous Protease Activity, Myofibrillar Degradation, and Quality Characteristics in Topmouth Culter ( Culter alburnus ) - Fan Wang; Jia-Liang He; Tursunay Turgun; Da-E Ge; Nurgul Rahman; Jian-Zhong Zhou; Xiao-Li Liu (Journal of Aquatic Food Product Technology, 2020)

Anisotropy of quartz mica schist based on quantitative extraction of fabric information - Xiaomeng Yin; E-chuan Yan; Lunan Wang; Linchao Liu; Bo Feng; Pengzhen Wang (Bulletin of Engineering Geology and the Environment, 2020)

Revisiting high-resolution crystal structure of Phormidium rubidum phycocyanin - Ravi R. Sonani; Aleksander W. Roszak; Haijun Liu; Michael L. Gross; Robert E. Blankenship; Datta Madamwar; Richard J. Cogdell (Photosynthesis Research, 2020)

Dual-sectored transurethral ultrasound for thermal treatment of stress urinary incontinence: in silico studies in 3D anatomical models - Dong Liu; Matthew Adams; E. Clif Burdette; Chris J. Diederich (Medical & Biological Engineering & Computing, 2020)

Activation of the Protective Arm of the Renin Angiotensin System in Demyelinating Disease - Roslynn E. Stone; Siyu Liu; Alexander M. Levy; Nicole Kashani; Stan G. Louie; Kathleen E. Rodgers; Eve E. Kelland; Brett T. Lund (Journal of Neuroimmune Pharmacology, 2020)

Expanding Urgent Oncofertility Services for Reproductive Age Women Remote from a Tertiary Level Fertility Centre by Use of Telemedicine and an On-site Nurse Navigator - Rhonda Zwingerman; Karen Melenchuk; Eileen McMahon; Kimberly E. Liu; Andrew Siren; Nicole Laferriere; Ellen M. Greenblatt (Journal of Cancer Education, 2020)

Pericytes, inflammation, and diabetic retinopathy - Benjamin G. Spencer; Jose J. Estevez; Ebony Liu; Jamie E. Craig; John W. Finnie (Inflammopharmacology, 2020)

Vehicular Particulate Matter (PM) Characteristics Impact Vascular Outcomes Following Inhalation - Katherine E. Zychowski; Christina R. Steadman Tyler; Bethany Sanchez; Molly Harmon; June Liu; Hammad Irshad; Jacob D. McDonald; Barry E. Bleske; Matthew J. Campen (Cardiovascular Toxicology, 2020)

Interaction with ectopic cochlear crista sensory epithelium disrupts basal cochlear sensory epithelium development in Lmx1a mutant mice - David H. Nichols; Judith E. Bouma; Benjamin J. Kopecky; Israt Jahan; Kirk W. Beisel; David Z. Z. He; Huizhan Liu; Bernd Fritzsch (Cell and Tissue Research, 2020)