Both AMP-activated and cAMP-dependent protein kinase regulate the expression of heat shock protein 70-2 gene in Neopyropia yezoensis - Zhenjie Sun; Wenhui Gu; Zezhong Feng; Yaqin Fan; Jianfeng Niu; Guangce Wang (Frontiers in Marine Science, 2022)
The upregulation of heat shock protein 70 ( hsp70 ) gene under high temperature stress is a common phenomenon. Although heat shock protein-mediated stress responses play an important role in intertidal Neopyropia yezoensis , the detailed regulatory mechanism of the hsp70 gene expression is still unclear. Here, a full-length sequence of the hsp70-2 gene was cloned and its’ expression regulation was analyzed. There was an activating transcription factors element (ATFE) of cAMP-dependent protein kinase (PKA) was found at the gene promoter region and a highly conserved deduced amino acid sequence with calmodulin-binding activity was detected. Reagents implicated in the induction of the hsp70 gene were then selected to treat the algal samples at 24°C, and the photosynthetic parameters, transcription and translation of this gene were determined. Results showed that quercetin inhibited the transcription of the hsp70-2 gene, significantly decreased the synthesis of the HSP70-2 protein, and lowered the photosynthetic activity of N. yezoensis under high temperature stress conditions. Although the addition of trifluoperazine (TFP), an inhibitor of calmodulin (CAM), downregulated the photosynthetic parameters, the transcription of the hsp70-2 gene was not influenced at high temperature treatment, implying that CAM was not involved in the transcription of the hsp70-2 gene but involved in the heat stress reponding pathways. 5′-aminoimidasole-4-carboxamide-1-β-d-ribofuranoside (AICAR) promoted the synthesis of hsp70-2 transcripts significantly and HSP70-2 protein slightly, which indicated that AMPK regulated the induction of the hsp70-2 gene in N. yezoensis . Forskolin also promoted the upregulation of the hsp70-2 gene. Thus, both AMPK and cAMP-dependent protein kinase (PKA) could phosphorylate HSF and activate the expression of the hsp70-2 gene in N. yezoensis . However, there was no strict correlation between transcripts of the hsp70-2 gene and HSP70-2 protein contents. It was proposed that the posttranscriptional mechanisms were involved in regulating the synthesis of the HSP70-2 protein. Which allowed it to adapt to the extremely variable intertidal environments with an instant responding manner, since the accumulated transcripts could be translated rapidly when needed.

Prediction of the Pitch and Heave Motions in Regular Waves of the DTMB 5415 Ship Using CFD and MMG - Han-Bing Sun; Shu-Qi Yang; Yang-Fan Xu; Jia-Feng Xiao (Journal of Marine Science and Engineering, 2022)
According to the requirement of high-performance development of modern ships, it is necessary to quickly and accurately predict the maneuverability of ships under wave conditions. In this paper, based on the CFD (Computational Fluid Dynamics) method in the commercial software STAR-CCM+, the numerical simulation of roll decay motion, pure heel motion, pure heave motion, and pure pitch motion of ship model 5415 is carried out. The relevant hydrodynamic derivatives are obtained, and the results are in good agreement with the experimental values. The equations of motion related to the heave and pitch motions are established according to the MMG (Maneuvering Motion Equation Research Group) model. Then, based on the above dynamic equations, the wave force module is added to successfully simulate and predict the pitch and heave responses of the ship under regular wave conditions, and it is concluded that the simulation model for rapid prediction is also applicable under waves.

Wheat bran, as the resource of dietary fiber: a review - Wen Cheng; Yujie Sun; Mingcong Fan; Yan Li; Li Wang; Haifeng Qian (Critical Reviews in Food Science and Nutrition, 2022)

Overexpression of PYGO1 promotes early cardiac lineage development in human umbilical cord mesenchymal stromal/stem cells by activating the Wnt/β-catenin pathway - Jie Shen; Xiushan Wu; Ping Zhu; Jian Zhuang; Bin Qin; Fang Sun; Wuzhou Yuan; Xiongwei Fan; Zhigang Jiang; Fang Li; Yongqing Li; Yuequn Wang; et al. (Human Cell, 2022)

Community structure and ecological quality assessment of macrobenthos in the coastal sea areas of Northern Yantai, China - Fan Li; Yuanqing Ma; Xiukai Song; Shaowen Li; Xiaomin Zhang; Xiuxia Wang; Tiantian Wang; Zhenning Sun (Frontiers in Marine Science, 2022)
Four cruises in the Bohai Sea and northern Yellow Sea off Yantai, China, in April and August of 2020, collected data on the species composition and community structure characteristics of macrobenthos in these sea areas. Temporal and spatial changes in the dominant macrobenthic species between April and August were also analyzed. The M-AMBI and environmental data were used to assess the benthic ecological quality of the coastal waters off Yantai. The results revealed differences in macrobenthic community structure and ecological quality status between the two sea areas. The main findings are as follows: A total of 7 phyla and 153 macrobenthic species were collected; 113 and 101 species were recorded in the Bohai Sea and northern Yellow Sea areas, respectively, and estimated abundance was 301 ind. m -2 and 598 ind. m -2 ( p < 0.01), and biomass was 10.20 g m -2 and 14.65 g m -2 , respectively. The dominant species comprised small-sized polychaetes and bivalves. The main dominant species were Glycinde bonhourei , Micronephthys oligobranchia , Sternaspis chinensis , and Moerella hilaris . The number of species differed significantly between seasons ( p < 0.05). A comparison of the dominant species and community structure of the macrobenthos between seasons showed that more obvious replacement occurred in the Bohai Sea. There were major differences in community structure of the macrobenthos between the two areas. Macrobenthos abundance was positively correlated with depth, dissolved oxygen, and sand substrate, and negatively correlated with bottom-water temperature, pH, and fine silt or clay substrate. In April, sites with low ecological value were at the ports of Laizhou and Longkou and Yangma Island, with the water quality likely affected by intensive bivalve aquaculture, port activities, and river discharge; in August, low-ecological-value sites were the middle of Laizhou Bay, Longkou Port, west of Daheishan Island, and coastal water between the cities of Yantai and Weihai. Overall, the sea areas off Yantai were generally deemed to be in a “good” state of ecological quality.

In vitro anti-PRV activity of dihydromyricetin from Ampelopsis grossedentata - Wei Sun; Shanshan Liu; Anfa Lu; Fan Yang; Junhong Duan (Natural Product Research, 2022)

Naturally-Occurring Antibodies Against Bim are Decreased in Alzheimer’s Disease and Attenuate AD-type Pathology in a Mouse Model - Jie-Ming Jian; Dong-Yu Fan; Ding-Yuan Tian; Yuan Cheng; Pu-Yang Sun; Cheng-Rong Tan; Gui-Hua Zeng; Chen-Yang He; Ye-Ran Wang; Jie Zhu; Xiu-Qing Yao; Yan-Jiang Wang; et al. (Neuroscience Bulletin, 2022)

MicroRNA alteration in cerebrospinal fluid from comatose patients with traumatic brain injury after right median nerve stimulation - Ying Jia; Yi-fan He; Ye Tian; Yuan-zhi Wang; Rui-ting Zhao; Xiao-chun Li; Jian Sun; Ying-sheng Wei; Shuo An; Heng-jie Yuan; Chun-xiao Wan; Rong-cai Jiang (Experimental Brain Research, 2022)

Establishment of pediatric developmental dysplasia of the hip biobank: Shanghai children’s hospital experience - Dan Yang; Shiqi Wang; Chenghui Ke; Qichao Ma; Lingyan Fan; Yichen Wang; Mengjie Chen; Hao Ying; Sun Wang; Qin Jiao; Yang Shen; Lihua Zhao (Cell and Tissue Banking, 2022)
Developmental dysplasia of the hip (DDH) is a debilitating condition that affects 1–7% of newborns. Children with DDH, not treated early and effectively, will easily lead to disability. A better understanding of the biology of DDH is critical to the development of prognostic biomarkers and novel therapies. The purpose of this study was to establish a biobank of DDH genetic resources, to facilitate clinical and basic scientific research. The biological specimen and clinical data of DDH were collected in Shanghai Children’s Hospital from 2014 to 2021. The collection of blood samples was performed at definitive diagnosis and review, tissue specimens were performed at definitive surgery. The clinical data was collected at the whole stage of DDH patients at diagnosis, treatment and follow-up. A total of 528 patients with DDH were enrolled in this study, 90 were men and 438 were women, with the mean age of 4.67 years. The numbers of tissue and blood specimens reached 2172 and 1490, respectively. The quality test results showed that the DNA concentration decreased slightly with the extension of storage time, but the DNA purity did not change. Meanwhile, the extension of storage time slightly affected the stability of protein of tissue samples but did not affect the expression of the housekeeping gene. The DDH biobank built has the potential of monitoring disease pathogenesis and progress, which could provide specimens to the researchers improving the biological understanding and provide guidance of clinical treatment of this disease to clinicians.

Soil causes gut microbiota to flourish and total serum IgE levels to decrease in mice - Dongrui Zhou; Na Li; Fan Yang; Honglin Zhang; Zhimao Bai; Yangyang Dong; Mengjie Li; Wenyong Zhu; Zhongjie Fei; Pengfeng Xiao; Xiao Sun; Zuhong Lu (Environmental Microbiology, 2022)
Summary Traditional farm environments induce protection from allergic diseases. In this study, farm environmental factors were classified into three categories, environmental microbes, soil, and organic matter. To explore the impact of soil and environmental microorganisms on gut microbiota and immune function, mice were fed sterilized soil and inhaling microbes, soil microbes, or non‐sterilized soil. Metagenomic sequencing results showed the intake of sterile soil, that is, inhaling a small amount of soil microbes in the air increased gut microbial diversity and the abundance of type III secretion system (T3SS) genes, and decreased serum immune IgE levels induced by 2‐4‐dinitrofluorobenzene (DNFB). The intake of soil microbes increased the abundance of genes involved in the metabolism of short‐chain fatty acids and amino acid biosynthesis. Meanwhile, the intake of soil increased gut microbial diversity, the abundance of T3SS genes and related infectious elements, and genes associated with the metabolism of short‐chain fatty acids and amino acid biosynthesis, and decreased serum IgE levels. Therefore, soil may be useful as a potential ‘prebiotic’ promoting the reproduction and growth of some intestinal microorganisms that harbour bacterial secretion system genes, especially those of T3SS, whose abundance was positively and significantly correlated with innate immune function of mice.

Real wine or not? Protecting wine with traceability and authenticity for consumers: chemical and technical basis, technique applications, challenge, and perspectives - Xiangyu Sun; Fan Zhang; Gastón Gutiérrez-Gamboa; Qian Ge; Pingkang Xu; Qianwen Zhang; Yulin Fang; Tingting Ma (Critical Reviews in Food Science and Nutrition, 2022)

PTEN-induced kinase 1 enhances the reparative effects of bone marrow mesenchymal stromal cells on mice with renal ischaemia/reperfusion-induced acute kidney injury - Chenyu Lin; Wen Chen; Yong Han; Yujie Sun; Xiaoqiong Zhao; Yuan Yue; Binyu Li; Wenmei Fan; Tao Zhang; Li Xiao (Human Cell, 2022)
Acute kidney injury (AKI) is a common severe acute syndrome caused by multiple factors and is characterized by a rapid decline in renal function during a short period. Bone marrow mesenchymal stromal cells (BMSCs) are effective in treating AKI. However, the mechanism of their beneficial effects remains unclear. PTEN-induced kinase 1 (PINK1) may play an important role in kidney tissue repair. In this study, we explored the effect of PINK1 overexpression on enhancing BMSC-mediated repair of AKI. In this study, ischaemia/reperfusion-induced AKI (IRI-AKI) in mice and a hypoxia-reoxygenation model in cells were established, and the indices were examined by pathology and immunology experiments. After ischaemia/reperfusion, PINK1 overexpression reduced apoptosis in injured kidney tissue cell, decreased T lymphocyte infiltration, increased macrophage infiltration, and alleviated the inflammatory response. PINK1 relieved the stress response of BMSCs and renal tubular epithelial cells (RTECs), reduced apoptosis, altered the release of inflammatory factors, and reduced the proliferation of peripheral blood mononuclear cells (PBMCs). In conclusion, BMSCs and RTECs undergo stress responses in response to hypoxia, inflammation and other conditions, and overexpressing PINK1 in BMSCs could enhance their ability to resist these stress reactions. Furthermore, PINK1 overexpression can regulate the distribution of immune cells and improve the inflammatory response. The regulation of mitochondrial autophagy during IRI-AKI maintains mitochondrial homeostasis and protects renal function. The results of this study provide new strategies and experimental evidence for BMSC-mediated repair of IRI-AKI.

Cellular Heterogeneity Facilitates the Functional Differences Between Hair Follicle Dermal Sheath Cells and Dermal Papilla Cells: A New Classification System for Mesenchymal Cells within the Hair Follicle Niche - Yuyang Gan; Hailin Wang; Lijuan Du; Kaitao Li; Qian Qu; Weiwen Liu; Pingping Sun; Zhexiang Fan; Jin Wang; Ruosi Chen; Zhiqi Hu; Yong Miao (Stem Cell Reviews and Reports, 2022)

Adipose Mesenchymal Stem Cell-Derived Exosomes Promote Wound Healing Through the WNT/β-catenin Signaling Pathway in Dermal Fibroblasts - Cong Li; Yu An; Yu Sun; Fan Yang; Quanchen Xu; Zhiguo Wang (Stem Cell Reviews and Reports, 2022)
The differentiation, migration, and proliferation of skin fibroblasts are identified as key factors in cutaneous wound healing. Adipose-derived mesenchymal stem cells (ADMSCs) and their exosomes (ADMSC-Exos) have been considered as potential therapeutic tools for tissue regeneration; however, the underlying mechanisms on cutaneous wound healing are still not well understood. In this study, we successfully obtained ADMSC-Exos and found ADMSC-Exos significantly promoted the migration and proliferation of fibroblasts in a dose-dependent manner in vitro. The expression levels of COL-I and COL-III in fibroblasts treated with ADMSC-Exos were significantly increased, while the expression level of α-SMA was decreased. In addition, the enhanced protein expression of WNT2b and β-catenin confirmed the activation of the WNT/β-catenin signaling pathway and the WNT/β-catenin inhibitor (XAV939) reversed the promoting effect of ADMSC-Exos on wound healing and the β-catenin expression. Taken together, our study partially elucidates the mechanism of ADMSC-Exos in wound healing, illustrating the potential of ADMSC-Exos as a new therapeutic approach to promote skin wound healing. Graphical Abstract

Benefits of Endophytic Fungus Phomopsis liquidambaris Inoculation for Improving Mineral Nutrition, Quality, and Yield of Rice Grains Under Low Nitrogen and Phosphorus Condition - Meng-Jun Tang; Fan Lu; Yang Yang; Kai Sun; Qiang Zhu; Fang-Ji Xu; Wei Zhang; Chuan-Chao Dai (Journal of Plant Growth Regulation, 2022)

Feed types affect the growth, nutrient utilization, digestive capabilities, and endocrine functions of Megalobrama amblycephala: a comparative study between pelleted and extruded feed - Chao-Fan He; Xiang-Fei Li; Guang-Zhen Jiang; Ling Zhang; Miao Sun; Ya-Ping Ge; Wei-Liang Chen; Wen-Bin Liu (Fish Physiology and Biochemistry, 2022)

Different toxicity to liver and gill of zebrafish by selenium nanoparticles derived from bio/chemical methods - Shuling Fan; Ying Yang; Lu Sun; Bin Yu; Chunxiao Dai; Yuanyuan Qu (Environmental Science and Pollution Research, 2022)

Altered topological properties of the intrinsic functional brain network in patients with right-sided unilateral hearing loss caused by acoustic neuroma - Zhiyuan Fan; Zhen Fan; Tianming Qiu; Liuxun Hu; Yuan Shi; Yunman Xia; Xiaoyi Sun; Yingjun Liu; Sichen Li; Mingrui Xia; Wei Zhu (Brain Imaging and Behavior, 2022)

Molecular characteristics and pathogenicity of an equid alphaherpesvirus 1 strain isolated in China - Yue Hu; Qinrui Jia; Jianhua Liu; Wencheng Sun; Zilei Bao; Chuanzhong Che; Guiling Wu; Bin Fan; Jarhen; Duoliang Ran (Virus Genes, 2022)

Variation of the floral traits and sexual allocation patterns of Clematis tangutica to the altitudinal gradient of the eastern Qinghai- Tibet Plateau - Xiang Zhao; Qinzheng Hou; Xue Su; Bo Qu; Baoli Fan; Hui Zhang; Kun Sun (Biologia, 2022)

Research on target detection of Engraulis japonicus purse seine based on improved model of YOLOv5 - Jiaze Zhang; Shuxian Wang; Shengmao Zhang; Fenghua Tang; Wei Fan; Shenglong Yang; Yongwen Sun; Yang Liu; Wenbin Zhu; Shan Zhang; Ruilin He (Frontiers in Marine Science, 2022)
The refined monitoring and identification of fishing operations by fishing vessels is of great significance and value to fishing vessels. In order to solve the problem of inaccurate statistics of current Engraulis japonicus fishing quota and classification, this paper proposes an improved identification algorithm based on YOLOv5. This method introduces the SENet attention mechanism into the YOLOv5 backbone network structure, integrates the target information in different periods of fishing operations, reduces the interference of complex backgrounds, improves the precision of model detection, and ensures real-time detection efficiency. The artificially shot Engraulis japonicus videos are used as the dataset of the study, and the video is converted into a picture format to realize pre-labeling and processing. The 5550 images are divided into the training set, validation set, and test set according to 8:1:1. In order to verify the validity of the data, a set of in the control experiment, the YOLOv5 backbone network was replaced by MobileNetV2 and the SENet attention mechanism was introduced, and four models were implemented for comparison. The experimental results show that the research algorithm can obtain a mean average precision (mAP) of 99.3%, a precision of 98.9%, and a recall of 98.7%, which are improved by 1.4%, 1.7% and 2.5% respectively compared with the original model. The experimental results match the expectations. According to the statistics of some categories, the Kalman filter and the Hungarian matching method are used to count the main categories of fishing baskets, and an accuracy of 96.5% can be obtained. The threshold method for fishing nets and processing vessels can obtain 85.8% and 75% accuracy. These results shows that this target detection research can provide new ideas for job identification of Engraulis japonicus and provide auxiliary means for job statistics.

Evaluation of LAI Estimation of Mangrove Communities Using DLR and ELR Algorithms With UAV, Hyperspectral, and SAR Images - Bolin Fu; Jun Sun; Yeqiao Wang; Wenlan Yang; Hongchang He; Lilong Liu; Liangke Huang; Donglin Fan; Ertao Gao (Frontiers in Marine Science, 2022)
The high-precision estimation of mangrove leaf area index (LAI) using a deep learning regression algorithm (DLR) always requires a large amount of training sample data. However, it is difficult for LAI field measurements to collect a sufficient amount of sample data in mangrove wetlands. To tackle this challenge, this paper proposed an approach for expanding training samples and quantitatively evaluated the performance of estimating LAI for mangrove communities using Deep Neural Networks (DNN) and Transformer algorithms. This study also explored the effects of unmanned aerial vehicle (UAV) and Sentinel-2A multispectral, orbital hyper spectral (OHS), and GF-3 SAR images on LAI estimation of different mangrove communities. Finally, this paper evaluated the LAI estimation ability of mangrove communities using ensemble learning regression (ELR) and DLR algorithms. The results showed that: (1) the UAV images achieved the better LAI estimation of different mangrove communities (R 2 = 0.5974–0.6186), and GF-3 SAR images were better for LAI estimation of Avicennia marina with high coverage (R 2 = 0.567). The optimal spectral range for estimating LAI for mangroves in the optical images was between 650–680 nm. (2) The ELR model outperformed single base model, and produced the high-accuracy LAI estimation (R 2 = 0.5266–0.713) for different mangrove communities. (3) The average accuracy (R 2 ) of the ELR model was higher by 0.0019–0.149 than the DLR models, which demonstrated that the ELR model had a better capability (R 2 = 0.5865–0.6416) in LAI estimation. The Transformer-based LAI estimation of A. marina (R 2 = 0.6355) was better than the DNN model, while the DNN model produced higher accuracy for Kandelia candel (KC) (R 2 = 0.5577). (4) With the increase in the expansion ratio of the training sample (10–50%), the LAI estimation accuracy (R 2 ) of DNN and Transformer models for different mangrove communities increased by 0.1166–0.2037 and 0.1037–0.1644, respectively. Under the same estimation accuracy, the sample enhancement method in this paper could reduce the number of filed measurements by 20–40%.

A review of seismo-electromagnetic research in China - Guoze Zhao; Xuemin Zhang; Juntao Cai; Yan Zhan; Qinzhong Ma; Ji Tang; Xuebin Du; Bing Han; Lifeng Wang; Xiaobin Chen; Qibin Xiao; Xiangyu Sun; et al. (Science China Earth Sciences, 2022)

Protective effect of nicorandil against myocardial ischemia/reperfusion injury mediated via IL33/ST2 signaling pathway - Yi Zheng; Xueyin Li; Fan Zhang; Bo Zhao; Wanting Du; Da Sun; Guangping Li (Molecular and Cellular Biochemistry, 2022)

High-throughput “read-on-ski” automated imaging and label-free detection system for toxicity screening of compounds using personalised human kidney organoids - Qizheng Wang; Jun Lu; Ke Fan; Yiwei Xu; Yucui Xiong; Zhiyong Sun; Man Zhai; Zhizhong Zhang; Sheng Zhang; Yan Song; Jianzhong Luo; Mingliang You; et al. (Journal of Zhejiang University-SCIENCE B, 2022)

Bacterial communities associated with hydromedusa Gonionemus vertens in different regions in Chinese coastal waters - Wenjin Hao; Lei Wang; Fan Li; Tingting Sun; Saijun Peng; Yongxue Li; Jianmin Zhao; Zhijun Dong (Journal of Oceanology and Limnology, 2022)

Microbial composition and nitrogen removal pathways in a novel sequencing batch reactor integrated with semi-fixed biofilm carrier: evidence from a pilot study for low- and high-strength sewage treatment - Peng-fei Chen; Rui-jian Zhang; Zhi-li Du; Guang-hua Wang; Hao-tao Dong; Bin Cui; Ru-pei Fan; Lu-xin Li; Qian-bin Wang; Ying-shi Liu; Zhi-min Sun (Environmental Science and Pollution Research, 2022)

The functional evolution and system equilibrium of urban and rural territories - Jie Fan; Sisi Li; Zhongrui Sun; Rui Guo; Kan Zhou; Dong Chen; Jianxiong Wu (Journal of Geographical Sciences, 2022)

Application of high-precision 3D seismics for gas hydrate exploration in Muli area of Qinghai Province, China—a case study - Baoqiang Zhang; Changqing Yu; Guowei Fan; Yinyin Sun; Jinbin Li (Arabian Journal of Geosciences, 2022)

Long-term trend analysis of wave characteristics in the Bohai Sea based on interpolated ERA5 wave reanalysis from 1950 to 2020 - Jichao Wang; Peidong Sun; Zhihong Liao; Fan Bi; Guiyan Liu (Acta Oceanologica Sinica, 2022)

Characteristics and influencing factors of frontal upwelling in the Yellow Sea in summer - Fan Sun; Fei Yu; Guangcheng Si; Jianfeng Wang; Anqi Xu; Jun Pan; Ying Tang (Acta Oceanologica Sinica, 2022)

Establishment and evaluation of qPCR and real‐time recombinase‐aided amplification assays for detection of largemouth bass ranavirus - Yanmin Guo; Yahui Wang; Zhaobin Fan; Xianlin Zhao; Sven M. Bergmann; Hanxu Dong; Yuqi Jin; Dongli Sun; Qianyi Mai; Weiqiang Liu; Weiwei Zeng (Journal of Fish Diseases, 2022)
Largemouth bass ranavirus disease (LMBVD) caused by largemouth bass ranavirus (LMBV) has resulted in severe economic losses in the largemouth bass ( Micropterus salmoide s) farming industry in China. Early and accurate diagnosis is the key measure for the prevention and control of LMBVD. In this study, a quantitative polymerase chain reaction (qPCR) and a real‐time recombinase‐aided amplification (real‐time RAA) assay were established for the detection of LMBV. The sensitivity and specificity of these two methods, and the efficacy for detection of LMBV from clinical samples were also evaluated. Results showed that the real‐time RAA reaction was completed in

Metagenomic analysis of the microbiome of the upper reproductive tract: combating ovarian cancer through predictive, preventive, and personalized medicine - Xu Qin; Jianglin Zhou; Zizhuo Wang; Chenzhao Feng; Junpeng Fan; Jia Huang; Dianxing Hu; Babak Baban; Shengqi Wang; Ding Ma; Chaoyang Sun; Zhe Zhou; et al. (EPMA Journal, 2022)
Purpose We investigated whether ovarian cancer could alter the genital microbiota in a specific way with clinical values. Furthermore, we proposed how such changes could be envisioned in a paradigm of predictive, preventive, and personalized medicine (PPPM). Methods The samples were collected using cotton swabs from the cervical, uterine cavity, fallopian tubes, and ovaries of patients subjected to the surgical procedures for the malignant/benign lesions. All samples were then analyzed by metagenomic shotgun sequencing. The distribution patterns and characteristics of the microbiota in the reproductive tract of subjects were analyzed and were interpreted in relation to the clinical outcomes of the subjects. Results While the ovarian cancer was able to alter the genital microbiota, the bacteria were the dominant microorganisms in all samples across all cohorts in the study (median 99%). The microbiota of the upper female reproductive tract were mainly from the cervical, identified by low bacterial biomass and high bacterial diversity. Ovarian cancer had a distinct microbiota signature. The tubal ligation affects its microbial distribution. There were no different species on the surface of platinum-sensitive ovarian tissues compared to samples from platinum-resistant patients. Conclusion The ovarian cancer–induced changes in microbiota magnify the potential of microbiota as a biotherapeutic modality in the treatment of ovarian cancer in this study and very likely for several malignancies and other conditions. Our findings demonstrated, for the first time, that microbiota could be dissected and applied in more specific fashion based on a predictive, preventive, and personalized medicine (PPPM) model in the treatment of ovarian cancer. Utilizing microbiota portfolio in a PPPM system in ovarian cancer would provide a unique opportunity to a clinically intelligent and novel approach in the treatment of ovarian cancer as well as several other conditions and malignancies.

Hasubanan alkaloids with anti-inflammatory activity from Stephania longa - Hui Liu; Wan-Qin Liao; Rong-Xiao Lin; Lixia Fan; Jinyan Sun; Hong-Yuan Chen; Fang Liu; An-Ping Yang (Natural Product Research, 2022)

Recent Progress in Modeling and Control of Bio-Inspired Fish Robots - Boai Sun; Weikun Li; Zhangyuan Wang; Yunpeng Zhu; Qu He; Xinyan Guan; Guangmin Dai; Dehan Yuan; Ang Li; Weicheng Cui; Dixia Fan (Journal of Marine Science and Engineering, 2022)
Compared with traditional underwater vehicles, bio-inspired fish robots have the advantages of high efficiency, high maneuverability, low noise, and minor fluid disturbance. Therefore, they have gained an increasing research interest, which has led to a great deal of remarkable progress theoretically and practically in recent years. In this review, we first highlight our enhanced scientific understanding of bio-inspired propulsion and sensing underwater and then present the research progress and performance characteristics of different bio-inspired robot fish, classified by the propulsion method. Like the natural fish species they imitate, different types of bionic fish have different morphological structures and distinctive hydrodynamic properties. In addition, we select two pioneering directions about soft robotic control and multi-phase robotics. The hybrid dynamic control of soft robotic systems combines the accuracy of model-based control and the efficiency of model-free control, and is considered the proper way to optimize the classical control model with the intersection of multiple machine learning algorithms. Multi-phase robots provide a broader scope of application compared to ordinary bionic robot fish, with the ability of operating in air or on land outside the fluid. By introducing recent progress in related fields, we summarize the advantages and challenges of soft robotic control and multi-phase robotics, guiding the further development of bionic aquatic robots.

Application of enzymatic hydrolysate of Ulva clathrata as biostimulant improved physiological and metabolic adaptation to salt-alkaline stress in wheat - Feiyu Li; Zhihua Wu; Siqi Zuo; Li Fan; Zhengpeng Wei; Ling Ma; Wenke Sun; Chunying Du; Ruizhi Liu; Peng Wang (Journal of Applied Phycology, 2022)

Itraconazole-Induced the Activation of Adenosine 5'-Monophosphate (Amp)-Activated Protein Kinase Inhibits Tumor Growth of Melanoma via Inhibiting ERK Signaling - Ni Fan; Yueping Sun; Lv Yan; Weining Chen; Yueping Wang; Shusheng Wang; Yu Song (Cell Biochemistry and Biophysics, 2022)

Investigating the effect of compaction on the anaerobic digestion process of rice straw - Guang-Yin Chen; Hai-Nan Cao; Xue-Qian Fan; Yi-Chen Sun; Jing Wang; Jin-Zhu Dong; Pei Wu (BioEnergy Research, 2022)

Liver transcriptome analyses of acute poisoning and recovery of male ICR mice exposed to the mushroom toxin α-amanitin - Zhijun Wu; Haijiao Li; Yizhe Zhang; Chunguang Ding; Wenjin Zhao; Jing Dai; Chengmin Yu; Qunmei Yao; Fenshuang Zheng; Jingguang Fan; Chengye Sun (Archives of Toxicology, 2022)

Volcanic rocks of the Elashan Formation in the Dulan-Xiangride Basin, East Kunlun Orogenic Belt, NW China: Petrogenesis and implications for Late Triassic geodynamic evolution - Xingzhu Fan; Fengyue Sun; Chenghan Xu; Dongqian Wu; Lu Yu; Li Wang; Cheng Yan; Shahzad Bakht (International Geology Review, 2022)

Biocontrol potential of endophytic Trichoderma citrinoviride HT-1 against root rot of Rheum palmatum through both antagonistic effects and induced systemic resistance - DaWei Chen; QinZheng Hou; BaoLi Fan; Hui Zhang; LingYun Jia; Kun Sun (World Journal of Microbiology and Biotechnology, 2022)

Ultrasound-induced biophysical effects in controlled drug delivery - Lulu Zhang; Zhuohua Lin; Lan Zeng; Fan Zhang; Lihong Sun; Suhui Sun; Ping Wang; Menghong Xu; Jinxia Zhang; Xiaolong Liang; Huiyu Ge (Science China Life Sciences, 2022)

Alpine soil microbial community structure and diversity are largely influenced by moisture content in the Zoige wetland - S. Fan; J. Qin; H. Sun; Z. Jia; Y. Chen (International Journal of Environmental Science and Technology, 2022)

Fluoride contamination, spatial variation, and health risk assessment of groundwater using GIS: a high-density survey sampling in Weifang City, North China - Jiutan Liu; Yuanyuan Ma; Zongjun Gao; Yuqi Zhang; Zengbing Sun; Tianzhu Sun; Haibin Fan; Bin Wu; Mingbo Li; Lili Qian (Environmental Science and Pollution Research, 2022)

Random forest method-based prediction and control of bridge pier displacements during construction of two overlapped EPBM tunnels - Gang Zheng; Xingyuan Gu; Tianqi Zhang; Jibin Sun; Weihong Zheng; Qi Fan; Jingbo Tong; Yu Diao (European Journal of Environmental and Civil Engineering, 2022)

Berberisides A-D: three novel prenylated benzoic acid derivatives and a clerodane glycoside from Berberis tsarica aherndt. - Zhao-Yue Dong; Qing-Hong Zeng; Lin Wei; Xin Guo; Yan Sun; Fan-Cheng Meng; Guo-Wei Wang; Xiao-Zhong Lan; Zhi-Hua Liao; Min Chen (Natural Product Research, 2022)

Analytical and experimental analysis of the shear strength of bolted saw-tooth joints - Hang Lin; Penghui Sun; Yifan Chen; Youyan Zhu; Xiang Fan; Yanlin Zhao (European Journal of Environmental and Civil Engineering, 2022)

Review of construction methods for whole-cell computational models - Jingru Zhou; Xingcun Fan; Lingfeng Cao; Huijie Sun; Jianye Xia; XueFeng Yan (Systems Microbiology and Biomanufacturing, 2022)

New Target of Oxidative Stress Regulation in Cochleae: Alternative Splicing of the p62/Sqstm1 Gene - Pengjun Li; Dan Bing; Xiaodi Wang; Jin Chen; Zhihui Du; Yanbo Sun; Fan Qi; Hanqi Chu (Journal of Molecular Neuroscience, 2022)

How habitat heterogeneity shapes bacterial and protistan communities in temperate coastal areas near estuaries - Zelong Zhao; Hongjun Li; Yi Sun; Kuishuang Shao; Xiaocheng Wang; Xindong Ma; Anyi Hu; Haikun Zhang; Jinfeng Fan (Environmental Microbiology, 2022)
Summary In this study, we investigated microbial communities (bacteria and protist) in two coastal areas near the estuaries of the Liaohe (LH) River and Yalujiang (YLJ) River in the Northwestern Pacific Ocean. Due to the existence of Liaodong Peninsula and different levels of urbanization, geographical segregation and significant environmental heterogeneity were observed between these two areas. There were significantly different regional species pools and biogeographic patterns for both bacterial and protistan communities between LH and YLJ coastal areas. Species turnover was the main mechanism driving β‐diversity patterns of both bacterial and protistan communities in each area. In addition, the contributed ratio of nestedness to the β‐diversity patterns was significantly higher for protists compared to bacteria. Variation in regional species pools was found to be the dominant driver of differences of bacterial and protistan communities between the LH and YLJ coastal areas. For a single‐studied area, local community assembly mechanisms, including heterogeneous selection and dispersal limitation, were found to shape the bacterial and protistan communities through calculation of the β‐deviation index. Among them, the relative importance of heterogeneous selection and dispersal limitation on the community assembly varied according to microorganism type and habitat.

Aldosterone dysregulation predicts the risk of mortality and rehospitalization in heart failure with a preserved ejection fraction - Bingbing Ke; Xin Tan; Lu Ren; Yangkai Fan; Yixin Zhang; Fengjuan Li; Qiqi Sun; Tong Liu; Lixin Jia; Yuan Wang; Jie Du (Science China Life Sciences, 2022)

Flavonoid biosynthesis in four Dendrobium species based on transcriptome sequencing and metabolite analysis - Yajuan Wang; Ning Jia; Peiyu Wang; Jiameng Liu; Jing Sun; Wei Ye; Bei Fan (Molecular Biology Reports, 2022)

Vermicompost Application Enhances Halophyte Suaeda salsa Performance and Improves Coastal Saline Soil Quality - Jing-Fang Cai; Xuan-Shao Liu; Kai Sun; Fan Jiang; Ming-Xiang Zhang; Hong-Li Li; Fei-Hai Yu (Journal of Soil Science and Plant Nutrition, 2022)

Alternation of stromatolites and vertical burrows controlled by storm processes and sea-level changes in the middle Cambrian carbonates of central China - Bingchen Liu; Mingyue Dai; Yong’an Qi; Xiaofang Sun; Wei Zheng; Min Wang; Zhifeng Xing; Da Li; Yuchao Fan (Journal of Earth System Science, 2022)

Identification of Benign and Malignant Lung Nodules in CT Images Based on Ensemble Learning Method - Yifei Xu; Shijie Wang; Xiaoqian Sun; Yanjun Yang; Jiaxing Fan; Wenwen Jin; Yingyue Li; Fangchu Su; Weihua Zhang; Qingli Cui; Yanhui Hu; Sheng Wang; et al. (Interdisciplinary Sciences: Computational Life Sciences, 2022)

Cross-Hole Radar Fractures Detection of Tunnel Side Wall Based on Full Waveform Inversion and Reverse Time Migration - Fahe Sun; Jiaxing Wang; Chuanyi Ma; Wenhan Li; Fengkai Zhang; Kerui Fan (Geotechnical and Geological Engineering, 2022)

Enhanced antibacterial effect against Enterococcus faecalis by silver ions plus Triton X-100 with low concentrations and cytotoxicity - Mengting Duan; Qing Sun; Wei Fan; Bing Fan (Brazilian Journal of Microbiology, 2022)

Hydro-thermal characteristics and deformation behaviors of silty clay subjected to freeze–thaw cycles - Jianguo Lu; Xusheng Wan; Zhongrui Yan; Nima Pirhadi; Xiaoyi Fan; Mingnan Sun (Arabian Journal of Geosciences, 2022)

Mesoporous Silica Carrier-Based Composites for Taste-Masking of Bitter Drug: Fabrication and Palatability Evaluation - Weifeng Zhang; Guoxiang Li; Chaoqiang Xiao; Xin Chang; Ying Sun; Weiping Fan; Bing Tian; Di Gao; Yao Xiao; Xueping Wu; Shuwang He; Guangxi Zhai (AAPS PharmSciTech, 2022)

Single-cell RNA sequencing reveals Nestin+ active neural stem cells outside the central canal after spinal cord injury - Muya Shu; Xiaoyu Xue; Hu Nie; Xianming Wu; Minghan Sun; Lianyong Qiao; Xing Li; Bai Xu; Zhifeng Xiao; Yannan Zhao; Yongheng Fan; Bing Chen; et al. (Science China Life Sciences, 2022)

Variations of human cerebral and ocular blood flow during exposure to multi-axial accelerations - Weipeng Li; Bitian Wang; Yawei Wang; Xiaoyu Liu; Wentao Feng; Tianya Liu; Zhujun Sun; Yu Liu; Songyang Liu; Yubo Fan (Medical & Biological Engineering & Computing, 2022)

MSTN is an important myokine for weight-bearing training to attenuate bone loss in ovariectomized rats - Liang Tang; Tingting Zhao; Yiting Kang; Shasha An; Xiushan Fan; Lijun Sun (Journal of Physiology and Biochemistry, 2022)

Seasonal Variation and Contamination Risk Assessment of Heavy Metals in Surface Sediment of an Estuary Alluvial Island in Eastern China - Yafeng Liu; Jiaxun Sun; Menglu Zhao; Yiyao Ni; Xiangrong Wang; Zhengqiu Fan (Bulletin of Environmental Contamination and Toxicology, 2022)

Integrative testing device for investigating the hydro-mechanical behavior of highly expansive clay - Yun-zhi Tan; Fan Peng; Hui Li; Hua-jun Ming; De-an Sun (Arabian Journal of Geosciences, 2022)

An innovative targeted therapy for fluoroscopy-induced chronic radiation dermatitis - Kai-Che Wei; Shih-Fan Lai; Wei-Lun Huang; Kuo-Chung Yang; Ping-Chin Lai; Wan-Ju Wei; Tsung-Hsien Chang; Yun-Chen Huang; Ya-Chuan Tsai; Shin-Chih Lin; Sun-Jang Lin; Shih-Chieh Lin (Journal of Molecular Medicine, 2022)
Fluoroscopy-induced chronic radiation dermatitis (FICRD) is a complication of fluoroscopy-guided intervention. Unlike acute radiation dermatitis, FICRD is different as delayed onset and usually appears without preexisting acute dermatitis. Unfortunately, the chronic and progressive pathology of FICRD makes it difficult to treat, and some patients need to receive wide excision and reconstruction surgery. Due to lack of standard treatment, investigating underlying mechanism is needed in order to develop an effective therapy. Herein, the Hippo pathway is specifically identified using an RNA-seq analysis in mild damaged skin specimens of patients with FICRD. Furthermore, specific increase of the Yes-associated protein (YAP1), an effector of the Hippo pathway, in skin region with mild damage plays a protective role for keratinocytes via positively regulating the numerous downstream genes involved in different biological processes. Interestingly, irradiated-keratinocytes inhibit activation of fibroblasts under TGF-β1 treatment via remote control by an exosome containing YAP1. More importantly, targeting one of YAP1 downstream genes, nuclear receptor subfamily 3 group C member 1 (NR3C1), which encodes glucocorticoid receptor, has revealed its therapeutic potential to treat FICRD by inhibiting fibroblasts activation in vitro and preventing formation of radiation ulcers in a mouse model and in patients with FICRD. Taken together, this translational research demonstrates the critical role of YAP1 in FICRD and identification of a feasible, effective therapy for patients with FICRD. Key messages • YAP1 overexpression in skin specimens of radiation dermatitis from FICRD patient. • Radiation-induced YAP1 expression plays protective roles by promoting DNA damage repair and inhibiting fibrosis via remote control of exosomal YAP1. • YAP1 positively regulates NR3C1 which encodes glucocorticoid receptor expression. • Targeting glucocorticoid receptor by prednisolone has therapeutic potential for FICRD patient.

Retraction Note to: Revisiting the male genetic landscape of China: a multi-center study of almost 38,000 Y-STR haplotypes - Michael Nothnagel; Guangyao Fan; Fei Guo; Yongfeng He; Yiping Hou; Shengping Hu; Jiang Huang; Xianhua Jiang; Wook Kim; Kicheol Kim; Chengtao Li; Hui Li; et al. (Human Genetics, 2022)

The influence of social pain experience on empathic neural responses: the moderating role of gender - Min Fan; Gaowen Yu; Donghuan Zhang; Nan Sun; Xifu Zheng (Experimental Brain Research, 2022)

Association of urinary phthalate metabolites with sarcopenia in US adults: NHANES 1999–2006 - Ye Yang; Li Ju; Jiayao Fan; Shaofang Cai; Lingling Sun; Yingjun Li (Environmental Science and Pollution Research, 2022)

Optimization and Application of an Efficient and Stable Inhalation Exposure System for Rodents - Zi Fan; Bo Zhou; Yujia Liu; Wu Sun; Yuntao Fang; Hongguo Lu; Dongya Chen; Kuikui Lu; Xinyue Wu; Tian Xiao; Wenjing Xie; Qian Bian (AAPS PharmSciTech, 2022)

A Comparative Study on the Characteristics of the Urbanization Processes Between China and India from 1992 to 2013 Using DMSP-OLS NTL Images - Guangwei Sun; Mengzhen Zhang; Junfu Fan; Qi Jiang; Jiahao Chen; Panpan Zhang (Journal of the Indian Society of Remote Sensing, 2021)

Replacement of dietary kelp meal with three macroalgae sources on the growth performance, immune responses and anti-stress capacity of abalone Haliotis discus hannai - Li Sun; Yanlin Guo; Suoli Ma; Wenhao Fan; Yue Liu; Danni Liu; Yanjiao Zhang; Wenbing Zhang; Kangsen Mai (Journal of Applied Phycology, 2021)

Elevated CO2 accelerated the bloom of three Ulva species after one life cycle culture - Yitao Wang; Dong Xu; Jian Ma; Xiaowen Zhang; Xiao Fan; Yan Zhang; Wei Wang; Ke Sun; Naihao Ye (Journal of Applied Phycology, 2021)

Practices of environmental protection, technological innovation, economic promotion and social equity in hydropower development: a case study of cascade hydropower exploitation in China’s Dadu River basin - Xuan Zhou; Shiyu Fan; Hui Sun; Liu Tang; Feiwen Ma (Clean Technologies and Environmental Policy, 2021)

Luteirhabdus pelagi gen. nov., sp. nov., a novel member of the family Flavobacteriaceae, isolated from the West Pacific Ocean - Wen-Ting Ren; Fan-Xu Meng; Li-Li Guo; Li Sun; Xue-Wei Xu; Peng Zhou; Yue-Hong Wu (Archives of Microbiology, 2021)
A Gram-stain-negative, aerobic, and yellow-pigmented bacterium, designated A3-108 T , was isolated from seawater of the West Pacific Ocean. Cells were non-motile and rod-shaped, with carotenoid-type pigments. Strain A3-108 T grew at pH 6.0–8.5 (optimum 6.5) and 15–40 °C (optimum 28 °C), in the presence of 0.5–10% (w/v) NaCl (optimum 1.0%). It possessed the ability to produce H 2 S. Based on the 16S rRNA gene analysis, strain A3-108 T exhibited highest similarity with Aureisphaera salina A6D-50 T (90.6%). Phylogenetic analysis shown that strain A3-108 T affiliated with members of the family Flavobacteriaceae and represented an independent lineage. The principal fatty acids were iso-C 15:0 , iso-C 17:0 3-OH, iso-C 15:1 G, and summed feature 3 (C 16:1 ω 7 c and/or C 16:1 ω 6 c ). The sole isoprenoid quinone was MK-6. The major polar lipids were phosphatidylethanolamine, one unidentified aminophospholipid, one unidentified aminolipid and one unidentified lipid. The ANIb, in silico DDH and AAI values among the genomes of strain A3-108 T and three reference strains were 67.3–71.1%, 18.7–22.1%, and 58.8–71.4%, respectively. The G + C content was 41.0%. Distinctness of the phylogenetic position as well as differentiating chemotaxonomic and other phenotypic traits revealed that strain A3-108 T represented a novel genus and species of the family Flavobacteriaceae , for which the name Luteirhabdus pelagi gen. nov., sp. nov. is proposed (type strain, A3-108 T = CGMCC 1.18821 T = KCTC 82563 T ).

Blasting relaxation characteristics of columnar jointed rock mass with AE technology - Xiang Xin; Fan Lei; Sun Zhiyu; Zhang Guangcheng; Zhang Shu; Zhang Yihu (Arabian Journal of Geosciences, 2021)

Tobacco as a potential raw material for drug production - Hao Niu; Peng Zhang; Bin Li; Shuguang Sun; Xiaoliang Yang; Fan He (Acta Physiologiae Plantarum, 2021)

The use of Eulerian finite element method in face stability analysis of shield tunnels in undrained clay - Gang Zheng; Jibin Sun; Tianqi Zhang; Qi Fan; Jingbo Tong; Haizuo Zhou; Yu Diao (European Journal of Environmental and Civil Engineering, 2021)

Culture Enrichment Combined With Long-Read Sequencing Facilitates Genomic Understanding of Hadal Sediment Microbes - Huan Wang; Meng Wang; Shen Fan; Jie Lu; Yi Lan; Menggong Li; Jiangyan Li; Rulong Liu; Jin Sun; Jiasong Fang; Pei-Yuan Qian; Yu-Zhong Zhang; et al. (Frontiers in Marine Science, 2021)
Culture enrichment was developed to discover the uncharted microbial species in the environmental microbiota. Yet this strategy has not been widely used to study microbes of deep-sea environments. Here, we report the cultivation and metagenomic analysis of oceanic sediment microbiota collected from 6,477 m deep in the Mariana Trench. The sediment samples were cultured anaerobically in the laboratory for 4 months, before being subjected to full-length 16S rRNA gene sequencing using the PacBio technique and metagenome sequencing using both the Illumina and Oxford Nanopore techniques. The 16S rRNA gene analyses revealed 437 operational taxonomic units specific to the cultured microbes, despite the lower diversity of the cultured microbiota in comparison with the original. Metagenome analyses revealed the prevalence of functions related to respiration, energy production, and stress response in the cultured microbes, suggesting these functions may contribute to microbial proliferation under laboratory conditions. Binning of the assembled metagenome contigs of the cultured microbiota generated four nearly complete genomes affiliated to yet unclassified species under the genera Alcanivorax , Idiomarina , Sulfitobacter , and Erythrobacter . Excepting Alcanivorax , the other three genera were almost undetectable in the original samples and largely enriched in the cultured samples. The four genomes possessed a variety of genes for carbohydrate utilization and nitrite reduction, pointing to an ability to respire diverse carbon sources using nitrite as the final electron acceptor. Taken together, the findings suggest that a combination of culture enrichment and long-read sequencing is an ideal way to mine novel microbial species in the hadal environment, particularly species that are rare in their native environmental niches, and thus expand our understanding of the hadal microbial diversity and function.

cFos-ANAB: A cFos-based Web Tool for Exploring Activated Neurons and Associated Behaviors - Fan Wang; Wenjie Sun; Lei Chang; Kefang Sun; Leying Hou; Linna Qian; Chaoyin Jin; Jiandong Chen; Jiali Pu; Panmeng Ye; Shuang Qiu; Jianhong Luo; et al. (Neuroscience Bulletin, 2021)

A landslide in Heifangtai, northwest of the Chinese Loess Plateau: triggered factors, movement characteristics, and failure mechanism - Jia-xu Kong; Jian-qi Zhuang; Jie-wei Zhan; Zheng-wei Bai; Yan-qiu Leng; Peng-hui Ma; Jian-bing Peng; Zuo-peng Wang; Tian-feng Gu; Jia-xing Sun; Fan-chen Zhang; Yuan-jun Xu; et al. (Landslides, 2021)

Two Foxo1 homologues in the orange-spotted grouper Epinephelus coioides: sequences, expression, and possible involvement in the activation of cyp19a1a expression in the ovary - Yunfeng Ning; Miao Fan; Qiongyou Liu; Huijie Lu; Shangyong Qian; Xin Cui; Feiyan Meng; Xi Li; Xing Xu; Shu Sun; Youwei Zhang; Lihong Zhang; et al. (Fish Physiology and Biochemistry, 2021)

3D surface-related multiples elimination based on improved apex-shifted Radon transform - Fan Yang; Deli Wang; Bin Hu; Hongyu Zhu; Jing Sun (Acta Geophysica, 2021)

Evaluation of the antiviral activity of naringenin, a major constituent of Typha angustifolia , against white spot syndrome virus in crayfish Procambarus clarkii - Zhong‐Chen Sun; Cheng Chen; Fei‐Fan Xu; Bing‐Ke Li; Jing‐Lei Shen; Tao Wang; Hai‐Feng Jiang; Gao‐Xue Wang (Journal of Fish Diseases, 2021)
White spot syndrome virus (WSSV) is a serious pathogen threatening global crustacean aquaculture with no commercially available drugs. Herbal medicines widely used in antiviral research offer a rich reserve for drug discovery. Here, we investigated the inhibitory activity of 13 herbal medicines against WSSV in crayfish Procambarus clarkii and discovered that naringenin (NAR) has potent anti‐WSSV activity. In the preliminary screening, the extracts of Typha angustifolia displayed the highest inhibitory activity on WSSV replication (84.62%, 100 mg/kg). Further, NAR, the main active compound of T. angustifolia, showed a much higher inhibition rate (92.85%, 50 mg/kg). NAR repressed WSSV proliferation followed a dose‐dependent manner and significantly improved the survival of WSSV‐challenged crayfish. Moreover, pre‐ or post‐treatment of NAR displayed a comparable inhibition on the viral loads. NAR decreased the transcriptional levels of vital genes in viral life cycle, particularly for the immediately early‐stage gene ie1 . Further results showed that NAR could decrease the STAT gene expression to block ie1 transcription. Besides, NAR modulated immune‐related gene Hsp70 , antioxidant ( cMnSOD, mMnSOD, CAT, GST ), anti‐inflammatory ( COX‐1 , COX‐2 ) and pro‐apoptosis‐related factors (Bax and BI‐1) to inhibit WSSV replication. Overall, these results suggest that NAR may have the potential to be developed as preventive or therapeutic agent against WSSV.

Vertical Fine-Scale Distribution of Calanus sinicus in the Yellow Sea Cold Water Mass During the Over-Summering Process - Jun Pan; Fangping Cheng; Fei Yu; Yongqiang Shi; Fan Sun; Guangcheng Si; Chuanjie Wei; Xinyuan Diao; Yongfang Zhao (Frontiers in Marine Science, 2021)
Calanus sinicus , a temperate copepod with a lethal temperature >27°C, is one of the key species in Chinese coastal marine ecosystems. The C. sinicus population increases in spring and declines in early summer annually due to increasing water temperature. Numerous C. sinicus individuals then congregate in the Yellow Sea Cold Water Mass (YSCWM) and remain under the thermocline from early summer to early autumn. Development and reproduction is halted in this cold and foodless bottom water and they avoid ascending to the hot surface water, which is regarded as an over-summering strategy. Based on discrete water sampling approaches, previous studies demonstrated that higher chlorophyll a (Chl a) levels appeared in the mixed hot surface water layer; however, the subsurface chlorophyll a maximum layer (SCML) has seldom been described. In the present study, various probes and a visual plankton recorder (VPR) were used to determine the fine vertical distributions of environmental factors and C. sinicus . VPR observations showed the ecological responses in fine scale and indicated that few C. sinicus individuals ascend at night, the main population preferred to remain below the SCML all day long. The results demonstrated that a constant thin SCML existed in the YSCWM area, and that the SCML location coincided with or was beneath the thermocline and halocline layers, where the temperature was suitable for C. sinicus . The relationship between abundance and Chl a, showed the diel vertical migration trend of C. sinicus to feed at night in the YSCWM area. In addition to temperature as a main influencing factor, dissolved oxygen concentrations and column depth were also influencing factors. Therefore, in addition to avoiding high surface temperature, energy supplement may be an important driving force confining the diel vertical migration of C. sinicus in the Yellow Sea in summer.

Interference of anthocyanin extracted from black soybean coats on aflatoxin B 1 -human serum albumin in the binding process - Tingting Fan; Yanli Xie; Shumin Sun (Food Additives & Contaminants: Part A, 2021)

Transcriptomics and targeted metabolomics reveal the regulatory network of Lilium davidii var. unicolor during bulb dormancy release - Xinyue Fan; Yue Yang; Min Li; Linlan Fu; Yuqing Zang; Chunxia Wang; Tianyou Hao; Hongmei Sun (Planta, 2021)

Octamer transcription factor-1 induces the Warburg effect via up-regulation of hexokinase 2 in non-small cell lung cancer - Zhen Li; Jin Su; Mingming Sun; Jiaqi Song; Huanran Sun; Jun Fan; Guo Chen; Changliang Shan; Qi Qi; Shuai Zhang (Molecular and Cellular Biochemistry, 2021)

Endoplasmic reticulum stress is involved in retinal injury induced by repeated transient spikes of intraocular pressure - Xue Yang; Xiaowei Yu; Zhenni Zhao; Yuqing He; Jiamin Zhang; Xiaoqian Su; Nannan Sun; Zhigang Fan (Journal of Zhejiang University-SCIENCE B, 2021)

Quantitative assessment of the habitat quality dynamics in Yellow River Basin, China - Yanan Song; Meng Wang; Xiaofang Sun; Zemeng Fan (Environmental Monitoring and Assessment, 2021)

Microbiogenic thrombolites from the Cambrian Miaolingian Series of southern North China Craton - Xiaofang Sun; Mingyue Dai; Yong’an Qi; Bingchen Liu; Wei Zheng; Zhifeng Xing; Min Wang; Da Li; Yuchao Fan (Carbonates and Evaporites, 2021)

Urban spatial structure analysis: quantitative identification of urban social functions using building footprints - Zhiyao Zhao; Xianwei Zheng; Hongchao Fan; Mengqi Sun (Frontiers of Earth Science, 2021)

Experimental study on grouting of elliptical fractured rock mass at various temperatures - Yongqiang Yu; Jiyun Zhang; Lidan Fan; Zhijie Shi; Liang Sun (Arabian Journal of Geosciences, 2021)

CsKTN1 for a katanin p60 subunit is associated with the regulation of fruit elongation in cucumber (Cucumis sativus L.) - Hui Wang; Jing Sun; Fan Yang; Yiqun Weng; Peng Chen; Shengli Du; Aimin Wei; Yuhong Li (Theoretical and Applied Genetics, 2021)

Coupling loss characteristics of N-P-C through runoff and sediment in the hilly region of SE China under simulated rainfall - Longzhou Deng; Tianyu Sun; Kai Fei; Liping Zhang; Xiaojuan Fan; Yanhong Wu; Liang Ni; Rui Sun (Environmental Science and Pollution Research, 2021)

Molecular mechanisms of heavy metals resistance of Stenotrophomonas rhizophila JC1 by whole genome sequencing - Shang-Chen Sun; Ji-Xiang Chen; Yong-Gang Wang; Fei-Fan Leng; Jian Zhao; Kai Chen; Qing-Chun Zhang (Archives of Microbiology, 2021)

Evaluating satellite hyperspectral (Orbita) and multispectral (Landsat 8 and Sentinel-2) imagery for identifying cotton acreage - Changwei Wang; Qi Chen; Haisheng Fan; Chaolong Yao; Xin Sun; Ji Chan; Jizhong Deng (International Journal of Remote Sensing, 2021)

Exploring marine endosymbiosis systems with omics techniques - Yisi Hu; Shuyan Sun; Huizhong Fan; Wenliang Zhou; Fuwen Wei (Science China Life Sciences, 2021)

Critical thinking on amyloid-beta-targeted therapy: challenges and perspectives - Bin-lu Sun; Yang Chen; Dong-yu Fan; Chi Zhu; Fan Zeng; Yan-jiang Wang (Science China Life Sciences, 2021)

Dynamic Breakage Characteristics of Shale with Different Bedding Angles under the Different Ambient Temperatures - Xueru Fan; Ning Luo; Hanliang Liang; Xin Sun; Cheng Zhai; Lixiang Xie (Rock Mechanics and Rock Engineering, 2021)

DNA Methyltransferase 1 Is Dysregulated in Parkinson’s Disease via Mediation of miR-17 - Hong-Qiu Zhang; Jian-Yong Wang; Zhao-Feng Li; Lei Cui; Shi-Shi Huang; Lan-Bing Zhu; Yue Sun; Rui Yang; Hui-Hui Fan; Xiong Zhang; Jian-Hong Zhu (Molecular Neurobiology, 2021)

The benefit of leafy vegetable as catch crop to mitigate N and P leaching losses in intensive plastic-shed production system - Hongdong Xiao; Xin Fan; Haijun Sun; Min Yu; Weiming Shi; Bhupinder Pal Singh; Dan A; Hailong Wang (Journal of Soils and Sediments, 2021)

Optimal Blends of Controlled-Release Urea and Conventional Urea Improved Nitrogen Use Efficiency in Wheat and Maize with Reduced Nitrogen Application - Zhen Fan; Jinxiu Chen; Sheng Zhai; Xinhui Ding; Huaizhen Zhang; Shuchen Sun; Xiaofei Tian (Journal of Soil Science and Plant Nutrition, 2021)

Using water-based drilling cuttings from shale gas development to manufacture sintered bricks: a case study in the southern Sichuan Basin, China - Wenshi Liu; Hui Yuan; Zhenzhen Fan; Jing Li; Lingru Sun (Environmental Science and Pollution Research, 2021)

Effects of high temperature on the mechanical behaviors of sandstone under true-triaxial unloading conditions - Fan Xiao; Deyi Jiang; Fei Wu; Quanle Zou; Jie Chen; Bo Chen; Zhongguang Sun (Bulletin of Engineering Geology and the Environment, 2021)

Age of the Silurian Lower Red Beds in South China: Stratigraphical Evidence from the Sanbaiti Section - Zhongyang Chen; Peep Männik; Junxuan Fan; Chengyuan Wang; Qing Chen; Zongyuan Sun; Dongyang Chen; Chao Li (Journal of Earth Science, 2021)

Transcriptome analysis reveals the effects of temperature on growth in tadpoles of spiny-bellied frog (Quasipaa boulengeri) - Wenqiao Fan; Mengjun Huang; Jingming Xu; Meixia Zhang; Yusong Jiang; Mingcheng Cai; Hanchang Sun; Xiaoying Li (Aquaculture International, 2021)

Two novel diterpenes from the stems and leaves of tropical seagrass Enhalus acoroides in the South China sea - Xiao-Bing Wang; Zhong-Hao Sun; Li-Xia Fan; Yang-Yang Liu; Jian Feng; Guo-Xu Ma; De-Li Chen (Natural Product Research, 2021)

Development of a pyrF-based counterselectable system for targeted gene deletion in Streptomyces rimosus - Yiying Yang; Qingqing Sun; Yang Liu; Hanzhi Yin; Wenping Yang; Yang Wang; Ying Liu; Yuxian Li; Shen Pang; Wenxi Liu; Qian Zhang; Fang Yuan; et al. (Journal of Zhejiang University-SCIENCE B, 2021)

Weight-bearing exercise prevents skeletal muscle atrophy in ovariectomized rats - Liang Tang; Wenxin Cao; Tingting Zhao; Kang Yu; Lijun Sun; Jianzhong Guo; Xiushan Fan; Dean Ta (Journal of Physiology and Biochemistry, 2021)

Divergent responses in morphology and life history to an Asplanchna kairomone between attached and free-swimming Brachionus dorcas (Rotifera) - Shan Jiang; Yan Bai; Fan Sun; Le-Le Ge; Yi-Long Xi (Hydrobiologia, 2021)

Nucleoprotein phosphorylation site (Y385) mutation confers temperature sensitivity to influenza A virus due to impaired nucleoprotein oligomerization at a lower temperature - Weinan Zheng; Liang Cui; Minghui Li; Yun Li; Wenhui Fan; Limin Yang; Jing Li; Lei Sun; Wenjun Liu (Science China Life Sciences, 2021)

Flavonoids improve drought tolerance of maize seedlings by regulating the homeostasis of reactive oxygen species - Baozhu Li; Ruonan Fan; Guiling Sun; Ting Sun; Yanting Fan; Shenglong Bai; Siyi Guo; Shiquan Huang; Jiong Liu; Hui Zhang; Pengtao Wang; Xiaohong Zhu; et al. (Plant and Soil, 2021)
Background and aims As drought threatens the yield and quality of maize ( Zea mays L.), it is important to dissect the molecular basis of maize drought tolerance. Flavonoids, participate in the scavenging of oxygen free radicals and alleviate stress-induced oxidative damages. This study aims to dissect the function of flavonoids in the improvement of maize drought tolerance. Methods Using far-infrared imaging screening, we previously isolated a drought overly insensitivity ( doi ) mutant from an ethyl methanesulfonate (EMS)-mutagenized maize library and designated it as doi57 . In this study, we performed a physiological characterization and transcriptome profiling of doi57 in comparison to corresponding wild-type B73 under drought stress. Results Under drought stress, doi57 seedlings displayed lower leaf-surface temperature (LST), faster water loss, and better performance in growth than B73. Transcriptome analysis reveals that key genes involved in flavonoid biosynthesis are enriched among differentially expressed genes in doi57 . In line with these results, more flavonols and less hydrogen peroxide (H 2 O 2 ) were accumulated in guard cells of doi57 than in those of B73 with the decrease of soil water content (SWC). Moreover, the capacity determined from doi57 seedling extracts to scavenge oxygen free radicals was more effective than that of B73 under the drought treatment. Additionally, doi57 seedlings had higher photosynthetic rates, stomatal conductance, transpiration rates, and water use efficiency than B73 exposed to drought stress, resulting in high biomass and greater root/shoot ratios in doi57 mutant plants. Conclusion Flavonoids may facilitate maize seedling drought tolerance by lowering drought-induced oxidative damage as well regulating stomatal movement.

Transgenic eukaryotic microalgae as green factories: providing new ideas for the production of biologically active substances - Qianwen Shi; Cheng Chen; Wei Zhang; Ping Wu; Meng Sun; Hui Wu; Haizhen Wu; Pengcheng Fu; Jianhua Fan (Journal of Applied Phycology, 2021)

Dynamics of leukocyte telomere length in adults aged 50 and older: a longitudinal population-based cohort study - Zhezhou Huang; Chazhen Liu; Ye Ruan; Yanfei Guo; Shuangyuan Sun; Yan Shi; Fan Wu (GeroScience, 2021)

Removal of Hg0, NO, and SO2 by the surface dielectric barrier discharge coupled with Mn/Ce/Ti-based catalyst - Ben Wang; Fan Yang; Zijian Song; Lushi Sun (Environmental Science and Pollution Research, 2021)

Abnormalities in the thalamo-cortical network in patients with functional constipation - Lei Liu; Chunxin Hu; Yang Hu; Wenchao Zhang; Zhida Zhang; Yueyan Ding; Yuanyuan Wang; Karen M. von Deneen; Lijuan Sun; Huaning Wang; Shijun Duan; Kuanrong Mao; et al. (Brain Imaging and Behavior, 2021)

Cotton seedling drought tolerance is improved via salt preconditioning - Rong Fan; Xiujuan Su; Yaping Guo; Fenglei Sun; Yanying Qu; Quanjia Chen (Protoplasma, 2021)

Peanut preinoculation with a root endophyte induces plant resistance to soil-borne pathogen Fusarium oxysporum via activation of salicylic acid-dependent signaling - Kai Sun; Xing-Guang Xie; Fan Lu; Feng-Min Zhang; Wei Zhang; Wei He; Chuan-Chao Dai (Plant and Soil, 2021)

Molecular diversity and genetic structure of wild rice accessions (Oryza rufipogon Griff.) in Guangdong Province, China, as revealed by SNP markers - Jing Zhang; Bingrui Sun; Chen Li; Wenfeng Chen; Liqun Jiang; Shuwei Lv; Zhilan Fan; Dajian Pan (Genetic Resources and Crop Evolution, 2021)

Contribution of groundwater discharge and associated contaminants input to Dongting Lake, Central China, using multiple tracers (222Rn, 18O, Cl−) - Xiaoliang Sun; Yao Du; Yamin Deng; Hongchen Fan; Yanqiu Tao; Teng Ma (Environmental Geochemistry and Health, 2021)

Pseudomonas pratensis sp. nov., Isolated from Grassland Soil from Inner Mongolia, China - Meng Zhang; Lixin Shen; Jiajia Shi; Linxia Chen; Ying Luo; Jiquan Sun; Deliang Fan; Shintaro Hara; Zhihua Bao (Current Microbiology, 2021)

Improved control of Frankliniella occidentalis on greenhouse pepper through the integration of Orius sauteri and neonicotinoid insecticides - Qing-cai Lin; Hao Chen; Dirk Babendreier; Jin-ping Zhang; Feng Zhang; Xiao-yan Dai; Zuo-wen Sun; Zhao-peng Shi; Xiao-lin Dong; Guang-an Wu; Yi Yu; Li Zheng; et al. (Journal of Pest Science, 2021)

Review on the treatment of organic wastewater by discharge plasma combined with oxidants and catalysts - Jiawei Fan; Haixia Wu; Ruoyu Liu; Liyuan Meng; Yongjun Sun (Environmental Science and Pollution Research, 2021)

Effects of tall fescue biochar on the adsorption and desorption of atrazine in different types of soil - Wanting Li; Ruifeng Shan; Yuna Fan; Xiaoyin Sun (Environmental Science and Pollution Research, 2021)

Characterization and Genomic Analysis of Escherichia coli O157:H7 Bacteriophage FEC14, a New Member of Genus Kuttervirus - Congcong Fan; Dandan Tie; Yanbo Sun; Jie Jiang; Honglan Huang; Yunwei Gong; Chunyan Zhao (Current Microbiology, 2021)

Adsorptive Removal of Low-Concentration Cr(VI) in Aqueous Solution by Mg–Al Layered Double Oxides - Lin Fan; Bo Zhou; Sheng Zhang; Sihai Hu; Xiaohui Mi; Ran Sun; Yaoguo Wu (Bulletin of Environmental Contamination and Toxicology, 2021)

Male Great Tits (Parus major) adjust dear enemy effect expression in different breeding stages - Longru Jin; Jingnan Liang; Qianxi Fan; Jiangping Yu; Keping Sun; Haitao Wang (Journal of Ornithology, 2021)

Two new lignans from Zanthoxylum armatum - Yan Sun; Qing-Hong Zeng; Hui-Qiang Lu; Fan-Cheng Meng; Yong Shen; Wei-You Zeng; Hao Chi; Yu-Qiang Zhou; Min Chen (Natural Product Research, 2020)

Effect of peach shell as lightweight aggregate on mechanics and creep properties of concrete - Fan Wu; Changwu Liu; Wei Sun; Yuanjun Ma; Lianwei Zhang (European Journal of Environmental and Civil Engineering, 2020)

BnA10.RCO, a homeobox gene, positively regulates leaf lobe formation in Brassica napus L. - Limin Hu; Hao Zhang; Yunxia Sun; Xiaoxiao Shen; Olalekan Amoo; Yuguang Wang; Chuchuan Fan; Yongming Zhou (Theoretical and Applied Genetics, 2020)

The Arabidopsis KH-domain protein FLOWERING LOCUS Y delays flowering by upregulating FLOWERING LOCUS C family members - Guang-Yi Dai; Ding-Kang Chen; Yun-Peng Sun; Wei-Yi Liang; Yu Liu; Li-Qun Huang; Yong-Kang Li; Jia-Fan He; Nan Yao (Plant Cell Reports, 2020)

Vision Fixation of Flightless Monophagous Leaf Beetle Ambrostoma quadriimpressum in Relation to Host Location - Fan Sun; Tianzhong Jing; Chao Bao; Jihua Hu (Journal of Insect Behavior, 2020)

Geographical origin differentiation of Chinese Angelica by specific metal element fingerprinting and risk assessment - Lei Sun; Xiao Ma; Hong-Yu Jin; Chang-jun Fan; Xiao-dong Li; Tian-Tian Zuo; Shuang-Cheng Ma; Sicen Wang (Environmental Science and Pollution Research, 2020)

Leaf nitrate accumulation influences the photorespiration of rice (Oryza sativa L.) seedlings - Yuming Sun; Yingrui Li; Bo Wang; Yong Li; Lei Ding; Min Wang; Luis Alejandro Jose Mur; Xiaorong Fan; Qirong Shen; Shiwei Guo (Plant and Soil, 2020)

Artemisinin suppresses myocardial ischemia–reperfusion injury via NLRP3 inflammasome mechanism - Fengyue Wang; Qianping Gao; Jing Yang; Can Wang; Junxian Cao; Junfeng Sun; Zhixin Fan; Lu Fu (Molecular and Cellular Biochemistry, 2020)

Structural Variability and Functional Prediction in the Epiphytic Bacteria Assemblies of Myriophyllum spicatum - Ling Xian; Tao Wan; Yu Cao; Junyao Sun; Ting Wu; Andrew Apudo Apudo; Wei Li; Fan Liu (Current Microbiology, 2020)

Toward Understanding the Differences of PM2.5 Characteristics Among Five China Urban Cities - Kaiyang Zhang; Chuanfeng Zhao; Hao Fan; Yikun Yang; Yue Sun (Asia-Pacific Journal of Atmospheric Sciences, 2020)

Distinct lung microbial community states in patients with pulmonary tuberculosis - Yongfeng Hu; Ying Kang; Xi Liu; Min Cheng; Jie Dong; Lilian Sun; Yafang Zhu; Xianwen Ren; Qianting Yang; Xinchun Chen; Qi Jin; Fan Yang (Science China Life Sciences, 2020)

LMDS-1, a potential TrkB receptor agonist provides a safe and neurotrophic effect for early-phase Alzheimer’s disease - Chia-Hao Fan; Chia-Wei Lin; Hei-Jen Huang; Guey-Jen Lee-Chen; Ying-Chieh Sun; Wenwei Lin; Chiung-Mei Chen; Kuo-Hsuan Chang; Ming-Tsan Su; Hsiu Mei Hsieh-Li (Psychopharmacology, 2020)

Air moisture and soil texture are crucial for the water dynamics of riparian bamboo in a subtropical region - Guo Chen; Xiaolu Tang; Chunju Cai; Shaohui Fan; Luanzi Sun; Fang Yang; Haitao Liu (Plant and Soil, 2020)

Screening for natural inhibitors of human topoisomerases from medicinal plants with bio-affinity ultrafiltration and LC–MS - Minxia Fan; Guilin Chen; Baoqing Sun; Jianlin Wu; Na Li; Satyajit D. Sarker; Lutfun Nahar; Mingquan Guo (Phytochemistry Reviews, 2020)

Occurrence and partitioning of brominated flame retardants (BFRs) in indoor air and dust: a 15-month case study in a test home - Jia-Qi Guo; Yong-feng Li; Li-Yan Liu; Chun-Yan Huo; Yu Sun; Wan-li Ma; Zi-feng Zhang; Yi-Fan Li (Environmental Science and Pollution Research, 2020)

Irregular structural networks of gray matter in patients with type 2 diabetes mellitus - Chuanlong Cao; Wanqing Liu; Qing Zhang; Jian-lin Wu; Yumei Sun; Danyang Li; Hongyu Fan; Feifei Wang (Brain Imaging and Behavior, 2020)

High-Resolution Projections of Mean and Extreme Precipitation over China by Two Regional Climate Models - Zhiyu Jiang; Zhan Tian; Guangtao Dong; Laixiang Sun; Peiqun Zhang; Erasmo Buonomo; Dongli Fan (Journal of Meteorological Research, 2020)

Polycyclic aromatic hydrocarbons (PAHs) and esophageal carcinoma in Handan-Xingtai district, North China: a preliminary study based on cancer risk assessment - Minmin Zhang; Jinxi Wang; Qiaojing Zhao; Vivek Mishra; Jingsen Fan; Yuzhuang Sun (Environmental Monitoring and Assessment, 2020)

Effect of rpoE on the Non-coding RNA Expression Profiles of Salmonella enterica serovar Typhi under the Stress of Ampicillin - Biying Zhang; Yinyin Fan; Min Wang; Jingnan Lv; Haifang Zhang; Lanyun Sun; Hong Du (Current Microbiology, 2020)

The correlation analyses of bacterial community composition and spatial factors between freshwater and sediment in Poyang Lake wetland by using artificial neural network (ANN) modeling - Ran Sun; Zuxin Tu; Lin Fan; Zixia Qiao; Xiaoyan Liu; Sihai Hu; Guohua Zheng; Yaoguo Wu; Ruiwu Wang; Xiaohui Mi (Brazilian Journal of Microbiology, 2020)

Extracellular ATP affects cell viability, respiratory O2 uptake, and intracellular ATP production of tobacco cell suspension culture in response to hydrogen peroxide-induced oxidative stress - Qin-zheng Hou; Yu-pei Wang; Bao-qiang Fan; Kun Sun; Jun-yu Liang; Han-qing Feng; Ling-yun Jia (Biologia, 2020)

A fundamental theorem for eco-environmental surface modelling and its applications - Tianxiang Yue; Na Zhao; Yu Liu; Yifu Wang; Bin Zhang; Zhengping Du; Zemeng Fan; Wenjiao Shi; Chuanfa Chen; Mingwei Zhao; Dunjiang Song; Shihai Wang; et al. (Science China Earth Sciences, 2020)

Sirt1-ROS-TRAF6 Signaling-Induced Pyroptosis Contributes to Early Injury in Ischemic Mice - Weijie Yan; Wei Sun; Jiahui Fan; Haiqing Wang; Song Han; Junfa Li; Yanling Yin (Neuroscience Bulletin, 2020)

Eukaryotic translation initiation factor 3 subunit b is a novel oncogenic factor in prostate cancer - Ping Xiang; Youwen Sun; Zhiqing Fang; Keqiang Yan; Yidong Fan (Mammalian Genome, 2020)

Light inhibition of carbon mineralization associated with iron redox processes in calcareous paddy soil - Xugang Wang; Lirong Sun; Zhihuai Chen; Dayong Guo; Haolong Fan; Xiaofeng Xu; Zhaoyong Shi; Xianni Chen (Journal of Soils and Sediments, 2020)

SCFAs induce autophagy in intestinal epithelial cells and relieve colitis by stabilizing HIF-1α - Chao Zhou; Liangzi Li; Teming Li; Lihua Sun; Jiuheng Yin; Haidi Guan; Liucan Wang; Hongbing Zhu; Peng Xu; Xin Fan; Baifa Sheng; Weidong Xiao; et al. (Journal of Molecular Medicine, 2020)

Establishment and characterization of silver-resistant Enterococcus faecalis - Jingwen Cui; Qing Sun; Mengting Duan; Danfeng Liu; Wei Fan (Folia Microbiologica, 2020)

Correction to: Characteristics of phosphorus adsorption and desorption in erosive weathered granite area and effects of soil properties - Tianyu Sun; Longzhou Deng; Kai Fei; Liping Zhang; Xiaojuan Fan (Environmental Science and Pollution Research, 2020)

Bioaccessibility and health risk assessment of trace metals in soils of greenhouse vegetable production near the industrial areas of the Yangtze River Delta, China - Lanqin Yang; Lin Di; Feili Sun; Wenfei Tian; Biao Huang; Gang Fan (Environmental Science and Pollution Research, 2020)

Characteristics of phosphorus adsorption and desorption in erosive weathered granite area and effects of soil properties - Tianyu Sun; Longzhou Deng; Kai Fei; Liping Zhang; Xiaojuan Fan (Environmental Science and Pollution Research, 2020)

Characteristics and Origins of Suspended Pyrite in the Mixing Zone of the Yangtze Estuary - Yue Pang; Dejiang Fan; Xiaoxia Sun; Xueshi Sun; Ming Liu; Zuosheng Yang (Journal of Ocean University of China, 2020)

Cytochrome P450 1A mRNA in the Gambusia affinis and Response to Several PAHs - Shaolin Xie; Aiguo Zhou; Yongyong Feng; Yue Zhang; Junyi Li; Zhuolin Sun; Lanfen Fan; Jixing Zou (Biochemical Genetics, 2020)

Characterization of a major quantitative trait locus on the short arm of chromosome 4B for spike number per unit area in common wheat (Triticum aestivum L.) - Jinghui Li; Shaozhe Wen; Chaofeng Fan; Minghu Zhang; Shuai Tian; Wenjing Kang; Wenxin Zhao; Chan Bi; Qiuyan Wang; Shuang Lu; Weilong Guo; Zhongfu Ni; et al. (Theoretical and Applied Genetics, 2020)

Characterization of viromes within mosquito species in China - Jiang Du; Fan Li; Yelin Han; Shihong Fu; Bo Liu; Nan Shao; Haoxiang Su; Weijia Zhang; Dandan Zheng; Wenwen Lei; Jie Dong; Lilian Sun; et al. (Science China Life Sciences, 2020)

To be the best in marine sciences - Song Sun; Fan Wang (Journal of Oceanology and Limnology, 2020)

Immersion test of loess in ground fissures in Shuanghuaishu, Shaanxi Province, China - Quanzhong Lu; Yang Liu; Jianbing Peng; Liang Li; Wen Fan; Nina Liu; Kai Sun; Rendao Liu (Bulletin of Engineering Geology and the Environment, 2020)

A stable regularization method of downward continuation of potential field - Jinpeng Li; Yingtang Zhang; Hongbo Fan; Zhining Li; Fucheng Sun (Studia Geophysica et Geodaetica, 2020)

Mixed secondary chromatin structure revealed by modeling radiation-induced DNA fragment length distribution - Wenzong Ma; Chenyang Gu; Lin Ma; Caoqi Fan; Chao Zhang; Yujie Sun; Cheng Li; Gen Yang (Science China Life Sciences, 2020)

Correction to: The structure–activity relationship review of the main bioactive constituents of Morus genus plants - Jiejing Yan; Jingya Ruan; Peijian Huang; Fan Sun; Dandan Zheng; Yi Zhang; Tao Wang (Journal of Natural Medicines, 2020)
The article The structure–activity relationship review of the main bioactive constituents of Morus genus plants, written by Jiejing Yan, Jingya Ruan, Peijian Huang, Fan Sun, Dandan Zheng, Yi Zhang and Tao Wang was originally published Online First without Open Access.

The Late Ordovician granitoids in the East Kunlun Orogenic Belt, Northwestern China: petrogenesis and constraints for tectonic evolution of the Proto-Tethys Ocean - Jinyu Li; Ye Qian; Haoran Li; Jinlei Sun; Ximing Yang; Bo Chen; Xingzhu Fan; Fengyue Sun (International Journal of Earth Sciences, 2020)

Geochemical characteristics of carbonate rocks in a salinized lacustrine basin: a case study from Oligocene formation in the Qaidam Basin, northwestern China - Qilin Chen; Daowei Zhang; Jiangong Wang; Fan Zhao; Yingru Liu; Zhenggang Zhang; Xiujian Sun; Chenggang Huang; Yadong Bai (Carbonates and Evaporites, 2020)

A flagellin-adjuvanted inactivated porcine epidemic diarrhea virus (PEDV) vaccine provides enhanced immune protection against PEDV challenge in piglets - Xiangwei Xu; Luping Du; Baochao Fan; Bing Sun; Jinzhu Zhou; Rongli Guo; Zhengyu Yu; Danyi Shi; Kongwang He; Bin Li (Archives of Virology, 2020)

A new diterpenoid alkaloid from Aconitum hemsleyanum - Zhi-Hui Luo; Yang Chen; Xin-Yi Sun; Hua Fan; Wei Li; Liang Deng; Tian-Peng Yin (Natural Product Research, 2020)

Biomechanical influence of anchorages on orthodontic space closing mechanics by sliding method - Zhan Liu; Tinghui Sun; Yubo Fan (Medical & Biological Engineering & Computing, 2020)

Spatio-temporal characteristics of agro-climatic indices and extreme weather events during the growing season for summer maize (Zea mays L.) in Huanghuaihai region, China - Zhentao Zhang; Xiaoguang Yang; Zhijuan Liu; Fan Bai; Shuang Sun; Jiayi Nie; Jiqing Gao; Bo Ming; Ruizhi Xie; Shaokun Li (International Journal of Biometeorology, 2020)

The soluble fraction from straw-derived biochar supplies nutrients and affects carbon storage of coastal mudflat soil in rice paddy - Jining Zhang; Sheng Zhou; Huifeng Sun; Fan Lü; Pinjing He (Environmental Science and Pollution Research, 2020)

Combined effects of nitrogen fertilizer and biochar on greenhouse gas emissions and net ecosystem economic budget from a coastal saline rice field in southeastern China - Liying Sun; Junyin Deng; Changhua Fan; Jia Li; Yinglie Liu (Environmental Science and Pollution Research, 2020)

Analysis of critical river discharge for saltwater intrusion control in the upper South Branch of the Yangtze River Estuary - Zhaohua Sun; Jiewei Fan; Xin Yan; Cuisong Xie (Journal of Geographical Sciences, 2020)

Genome-wide identification of long non-coding RNAs and circular RNAs reveal their ceRNA networks in response to cucumber green mottle mosaic virus infection in watermelon - Yuyan Sun; Huiqing Zhang; Min Fan; Yanjun He; Pingan Guo (Archives of Virology, 2020)

Advances in Studies on Toxic Effects of Short-Chain Chlorinated Paraffins (SCCPs) and Characterization of Environmental Pollution in China - Xin Zheng; Qianhang Sun; Shuping Wang; Xiaoqian Li; Peiyuan Liu; Zhenguang Yan; Xianghui Kong; Juntao Fan (Archives of Environmental Contamination and Toxicology, 2020)

Provenance analysis of the Cretaceous Laiyang Group on Lingshan Island (western Yellow Sea, China) and its tectono-sedimentary implications - A. P. Fan; S. N. Sun; R. C. Yang; Z. Zhang; S. De; J. D. N. Nenzhelele; Y. Li; H. P. Liu; Y. Q. Zhou; J. Yuan (Australian Journal of Earth Sciences, 2020)

Simvastatin decreases the silver resistance of E. faecalis through compromising the entrapping function of extracellular polymeric substances against silver - Jingwen Cui; Mengting Duan; Qing Sun; Wei Fan (World Journal of Microbiology and Biotechnology, 2020)

A fast, simple, high efficient and one-step generation of composite cucumber plants with transgenic roots by Agrobacterium rhizogenes-mediated transformation - Yinglun Fan; Fenglin Xu; Huizhen Zhou; Xinxin Liu; Xinyue Yang; Kaixia Weng; Xinlu Sun; Shanhua Lyu (Plant Cell, Tissue and Organ Culture (PCTOC), 2020)
Agrobacterium rhizogenes -mediated transformation is widely used in different species with various purposes. The development of composite plants (wild-type shoot with transgenic roots) has been a milestone for functional characterization of genes. Previously, composite plants were generated by two steps from inducing of hairy roots to growing in the growth medium. Hairy roots were induced in an induction medium and the growth of composite plants generated were in another different growth medium. The composite plants produced was subject to transplanting. Here, we describe an improved and optimized protocol for generation of composite plant achieved by one-step in cucumber, which has not been reported previously in living plants. Incubation of explants post inoculation to induce transgenic roots and the growth of rooted explants were in the same medium. The primary root of 5-day-old seedling was excised and the slant cut of residual hypocotyl with 1 cm length was inoculated with A. rhizogenes harboring the desired gene construct followed by directly planted into a pot with wet sterile vermiculite. More than 90% of the infected seedlings can produce positive transgenic root. In addition, we further used the one-step transformation protocol to analyze the function of Arabidopsis YAO promoter. The result indicated that p YAO :: GUS was highly conserved expression in whole root and high activity in the root tips. Therefore, a fast, expedient, high efficient, and one-step transformation method of composite cucumber produced is established, which is suitable for promoter functional analysis and other root-related events.

Characterization of brain microstructural abnormalities in cirrhotic patients without overt hepatic encephalopathy using diffusion kurtosis imaging - Qing Sun; Wenliang Fan; Yuan Liu; Yan Zou; Natalie Wiseman; Zhifeng Kou; Ping Han (Brain Imaging and Behavior, 2020)
Cirrhosis is a major public health concern. However, little is known about the neurobiological mechanisms underlying brain microstructure alterations in cirrhotic patients. The purpose of this prospective study was to investigate brain microstructural alterations in cirrhosis with or without minimal hepatic encephalopathy (MHE) and their relationship with patients’ neurocognitive performance and disease duration using voxel-based analysis of diffusion kurtosis imaging (DKI). DKI data were acquired from 30 cirrhotic patients with MHE, 31 patients without MHE (NMHE) and 59 healthy controls. All DKI-derived parametric maps were compared across the three groups to investigate their group differences. Correlation analyses were further performed to assess relationships between altered imaging parameters and clinical data. Voxel-based analysis of DKI data results showed that MHE/NMHE patients had increased radial diffusivity, axial diffusivity (AD) and mean diffusivity in addition to decreased axial kurtosis (AK) and fractional anisotropy of kurtosis in several regions. Compared to controls, these regions were primarily the cingulum, temporal and frontal cortices. The DKI metrics (i.e., AK and AD) were correlated with clinical variables in the two patient groups. In conclusion, DKI is useful for detecting brain microstructural abnormalities in MHE and NMHE patients. Abnormal DKI parameters suggest alterations in brain microstructural complexity in cirrhotic patients, which may contribute to the neurobiological basis of neurocognitive impairment. These results may provide additional information on the pathophysiology of cirrhosis.

Landcover classification of satellite images based on an adaptive interval fuzzy c-means algorithm coupled with spatial information - Jindong Xu; Guozheng Feng; Baode Fan; Weiqing Yan; Tianyu Zhao; Xiao Sun; Meng Zhu (International Journal of Remote Sensing, 2020)

Atorvastatin ameliorates depressive behaviors and neuroinflammatory in streptozotocin-induced diabetic mice - Zhang Hai-Na; Yu Xu-Ben; Tang Cong-Rong; Cao Yan-Cheng; Yang Fan; Xu Lei-Mei; Sun Ruo-Lan; Ye-Zi; Wang Ye-Xuan; Liang Jing (Psychopharmacology, 2020)

ABA and sucrose co-regulate strawberry fruit ripening and show inhibition of glycolysis - Ya Luo; Cong Ge; Yajie Ling; Fan Mo; Min Yang; Leiyu Jiang; Qing Chen; Yuanxiu Lin; Bo Sun; Yong Zhang; Yan Wang; Mengyao Li; et al. (Molecular Genetics and Genomics, 2020)

The structure–activity relationship review of the main bioactive constituents of Morus genus plants - Jiejing Yan; Jingya Ruan; Peijian Huang; Fan Sun; Dandan Zheng; Yi Zhang; Tao Wang (Journal of Natural Medicines, 2020)
Morus genus plants are mainly distributed in the temperate to tropical areas over the world and include 17 species and two subspecies. Due to their excellent pharmacological activity, security in food additives and high value in the national economy, Morus genus plants have drawn more and more attention in recent years. In the light of the references published over the last few decades, flavonoids, benzofurans, stilbenes, and Diels–Alder adducts have been reported to be the main bioactive constituents of Morus genus plants. This review summarizes the compounds with excellent bioactivities isolated from Morus genus plants as well as their structure–activity relationships (SARs), which might be useful for the further research and development of Morus genus plants. Graphic abstract The aromatic heterocycles with excellent bioactivities isolated from Morus genus plants as well as their structure–activity relationships (SARs) were summarized.

Prolonged Neo-Tethyan magmatic arc in Myanmar: evidence from geochemistry and Sr–Nd–Hf isotopes of Cretaceous mafic–felsic intrusions in the Banmauk–Kawlin area - Jin-Xiang Li; Wei-Ming Fan; Li-Yun Zhang; Tou-Ping Peng; Ya-Li Sun; Lin Ding; Fu-Long Cai; Kyaing Sein (International Journal of Earth Sciences, 2020)

Agro-ecological suitability assessment of Chinese Medicinal Yam under future climate change - Dongli Fan; Honglin Zhong; Biao Hu; Zhan Tian; Laixiang Sun; Günther Fischer; Xiangyi Wang; Zhiyu Jiang (Environmental Geochemistry and Health, 2020)
Chinese Medicinal Yam (CMY) has been prescribed as medicinal food for thousand years in China by Traditional Chinese Medicine (TCM) practitioners. Its medical benefits include nourishing the stomach and spleen to improve digestion, replenishing lung and kidney, etc., according to the TCM literature. As living standard rises and public health awareness improves in recent years, the potential medicinal benefits of CMY have attracted increasing attention in China. It has been found that the observed climate change in last several decades, together with the change in economic structure, has driven significant shift in the pattern of the traditional CMY planting areas. To identify suitable planting area for CMY in the near future is critical for ensuring the quality and supply quantity of CMY, guiding the layout of CMY industry, and safeguarding the sustainable development of CMY resources for public health. In this study, we first collect 30-year records of CMY varieties and their corresponding phenology and agro-meteorological observations. We then consolidate these data and use them to enrich and update the eco-physiological parameters of CMY in the agro-ecological zone (AEZ) model. The updated CMY varieties and AEZ model are validated using the historical planting area and production under observed climate conditions. After the successful validation, we use the updated AEZ model to simulate the potential yield of CMY and identify the suitable planting regions under future climate projections in China. This study shows that regions with high ecological similarity to the genuine and core producing areas of CMY mainly distribute in eastern Henan, southeastern Hebei, and western Shandong. The climate suitability of these areas will be improved due to global warming in the next 50 years, and therefore, they will continue to be the most suitable CMY planting regions.

Seismic design and behavior of self-centering energy dissipation braced steel frame - Long-He Xu; Yu-Sheng Sun; Xiao-Wei Fan; Zhong-Xian Li (Bulletin of Earthquake Engineering, 2020)

Inulin catabolism in Saccharomyces cerevisiae is affected by some key glycosylation sequons of invertase Suc2 - Fan Yang; Xinyu Zhang; Yuting Lu; Biying Wang; Xiaoyi Chen; Zhen Sun; Xianzhen Li (Biotechnology Letters, 2020)

Genetic architecture of subspecies divergence in trace mineral accumulation and elemental correlations in the rice grain - Yongjun Tan; Liang Sun; Qingnan Song; Donghai Mao; Jieqiang Zhou; Youru Jiang; Jiurong Wang; Tony Fan; Qihong Zhu; Daoyou Huang; Han Xiao; Caiyan Chen (Theoretical and Applied Genetics, 2020)

Heavy metals in soil of an urban industrial zone in a metropolis: risk assessment and source apportionment - Yanyao Li; Yuan Yuan; Chengju Sun; Ting Sun; Xianglin Liu; Jianbin Li; Lei Fang; Zhengqiu Fan (Stochastic Environmental Research and Risk Assessment, 2020)

Influence of Pore Water (Ice) Content on the Strength and Deformability of Frozen Argillaceous Siltstone - Hailiang Jia; Fan Zi; Gengshe Yang; Guoyu Li; Yanjun Shen; Qiang Sun; Pengyu Yang (Rock Mechanics and Rock Engineering, 2020)

Debunking the forest rent model fallacy in a fully regulated forest - Sun Joseph Chang; Yan Chen; Fan Zhang (European Journal of Forest Research, 2020)

Uptake, depuration, bioaccumulation, and selective enrichment of dechlorane plus in common carp (Cyprinus carpio) - Dapeng Wang; Hongliang Jia; Wen-Jun Hong; Xiaohong Xue; Yeqing Sun; Yi-Fan Li; Weijun Guo (Environmental Science and Pollution Research, 2020)

Autophagy May Be Involved in Fluoride-Induced Learning Impairment in Rats - Chengzhi Zhang; Simeng Huo; Yumei Fan; Yanhui Gao; Yanmei Yang; Dianjun Sun (Biological Trace Element Research, 2020)

The Mineral Composition and Sources of the Fine-Grained Sediments from the 49.6°E Hydrothermal Field at the SWIR - Wenqiang Zhang; Xiaoxia Sun; Dejiang Fan; Ming Liu; Qi Jia; Zuosheng Yang (Journal of Ocean University of China, 2020)

Spatial distribution characteristics of bacterial community structure and gene abundance in sediments of the Bohai Sea - Quanrui Chen; Jingfeng Fan; Jie Su; Hongxia Ming; Zhihao Sun; Mengfei Li; Xiaohui Zhao; Yantao Wang; Yingxue Zhang; Huizhen Zhang; Yuan Jin; Xiaowan Ma; et al. (Acta Oceanologica Sinica, 2020)

Eddy induced SST variation and heat transport in the western North Pacific Ocean - Bowen Sun; Chuanyu Liu; Fan Wang (Journal of Oceanology and Limnology, 2020)

Physiological response of Secale cereale L. seedlings under freezing-thawing and alkaline salt stress - Ze Gong; Weiwei Chen; Guozhang Bao; Jiaxing Sun; Xuemei Ding; Cunxin Fan (Environmental Science and Pollution Research, 2020)

Determination of Reference Intervals of Ratios of Concentrations of Urinary Iodine to Creatinine and Thyroid Hormone Concentrations in Pregnant Women Consuming Adequate Iodine in Harbin, Heilongjiang Province - Chunlei Ji; Ye Bu; Chunyuan Tian; Lijun Fan; Shoujun Liu; Ying Liu; Dianjun Sun (Biological Trace Element Research, 2020)