A robust trend estimator for GNSS time series in the presence of complex periodicity and its evaluation on multi-source products of IGS and IGMAS - Xiaohui Zhou; Yilin Yang; Qusen Chen; Wenlan Fan; Yifang Ma (GPS Solutions, 2022)

Identification of terrigenous and autochthonous organic carbon in sediment cores from cascade reservoirs in the upper stream of Pearl River and Wujiang River, southwest China: lignin phenol as a tracer - Li Gao; Xin Lin; Jun Fan; Ming Yang; Xueping Chen; Fushun Wang; Jing Ma (Acta Geochimica, 2022)

Establishment and characterization of a spinal cord tissue cell line from mandarin fish, Siniperca chuatsi and its susceptibility to several viruses - Jinpeng Gong; Xiaoyi Pan; Lingyun Lin; Yue Zhu; Jiayun Yao; Congxu Wang; Wenlin Yin; Lei Huang; Yihan Liu; Fan Chen; Jinyu Shen (Journal of Fish Diseases, 2022)
In this study, we established and characterized a continuous cell line from the spinal cord tissue of mandarin fish, Siniperca chuatsi and assessed its susceptibility to infectious spleen and kidney necrosis virus (ISKNV), Siniperca chuatsi ranavirus (SCRaV) and Siniperca chuatsi rhabdovirus (SCRV). The cell line, named SCC, has been successively cultured up to 40 passages. The optimal growing conditions of SCC cells were in Leibovitz's L‐15 medium supplemented with 20% foetal bovine serum (FBS) at 28°C. Karyotype analysis demonstrated 48 normal diploid chromosomes in the cells. The identity of S. chuatsi origin of SCC cells was confirmed by partial sequencing of the 16S rRNA and cytochrome oxidase I ( COI ) genes. Infection susceptibility assessment showed that ISKNV, SCRIV and SCRV and can be stably produced and transmitted in SCC cells, and the replication efficiency of ISKNV, SCRaV and SCRV ranged from 10 7.4 to 10 9.6 TCID 50 /ml. In addition, transmission electron microscopy analysis of ISKNV, SCRAV and SCRV infected SCC cells showed numerous viral particles. In conclusion, the newly established SCC cells provide an important tool for isolation and production of viruses, as well as for molecular and cell biology studies.

Stable carbon isotopes of dissolved inorganic carbon in the Western North Pacific Ocean: Proxy for water mixing and dynamics - Tiantian Ge; Chunle Luo; Peng Ren; Hongmei Zhang; Di Fan; Hongtao Chen; Zhaohui Chen; Jing Zhang; Xuchen Wang (Frontiers in Marine Science, 2022)
The uptake of atmospheric CO 2 and the cycle of dissolved inorganic carbon (DIC) in the ocean are the major mechanisms and pathways controlling global climate change and carbon cycling. The stable carbon isotope (δ 13 C) of DIC, therefore, provides an important tracer for processes such as air-sea exchange, photosynthesis, and water dynamics in the ocean. Here, we present new δ 13 C-DIC data on water samples collected from a north-south transect (13°N–40°N, 150°E) in the western North Pacific (NP) Ocean in November 2019 and compare the results with those previously reported for similar transects (149.3°E) during WOCE and CLIVAR projects over the past three decades. The values of δ 13 C-DIC, ranging from -0.83‰ to 0.86‰, were higher in the surface waters and decreased with depth. The high δ 13 C-DIC values in the surface waters were influenced primarily by isotopic fractionation during air-sea exchange and photosynthesis. With depth, the movement of different water masses and mixing, as well as bathypelagic respiration in the dark water of the ocean, all play important roles in influencing the distribution and isotopic signatures of δ 13 C-DIC in the western NP Ocean. The δ 13 C-DIC values of the 0–200 m water layer varied from -0.17‰ to 0.86‰, with lower values at high latitudes, affected by the low δ 13 C-DIC values carried by the Oyashio Current to the Kuroshio Extension (KE) region. A downward trend was present in the δ 13 C-DIC signature from north to south in the North Pacific Intermediate Water (NPIW) and Pacific Deep Water (PDW) in the western NP, which reflected the remineralization of organic matter with a horizontal transport of NPIW and PDW. We found a strong 13 C Suess Effect in the upper 2,000 m in the western NP Ocean, and δ 13 C-DIC at the surface (<50 m) has decreased by 0.60‰-0.85‰ since 1993. The mean δ 13 C-DIC change in the surface ocean was estimated at 0.28‰ per decade between 1993 and 2019. The air-sea exchange and water mixing in the study area may have accelerated the absorption of anthropogenic CO 2 in recent years, which likely caused a slightly faster rate of decrease in the δ 13 C-DIC from 2005–2019 than that observed from 1993–2005.

Development of spirotetramat nanoparticles based on mesoporous silica: improving the uptake and translocation of spirotetramat in plants - Zhichao Wang; Wangjin Xu; Zhiyuan Meng; Tianle Fan; Chunmei Yang; Jianjun Wang; Xiaojun Chen (Environmental Science and Pollution Research, 2022)

A real-time passive acoustic monitoring system to detect Yangtze finless porpoise clicks in Ganjiang River, China - Weilun Li; Jiansong Qiu; Peiyu Lei; Xiaohong Chen; Fei Fan; Xiaojun Deng; Yingen Dai; Yanqing Deng; Kexiong Wang; Zhigang Mei (Frontiers in Marine Science, 2022)
Phocoenidae live in fresh, coastal waters where they often share a significant portion of their habitat with humans. As a result, local activities (e.g., coastal fisheries and shipments) cause underwater noise pollution and threaten their ecosystem. To better conserve the habitat of porpoises, we aimed to study their activities in these waters by recording their echolocation clicks using a passive acoustic monitoring (PAM) system. However, because the off-line PAM instruments were often used in the past that need to be periodically deployed and recovered, data acquisition is typically obtained and analyzed in batches, rather than in real-time. A real-time PAM detection system would help minimize the impact of underwater noise on approaching porpoises. Furthermore, issues of bad quality data–with gaps due to loss or damage of the off-line PAM instruments–could be avoided with a real-time detection system. Therefore, in this study, we developed the Real-time Porpoise Click Detector-II (RPCD-II), equipped with a digital hydrophone, main memory (2 TB storage), a central processing unit, and a wireless transmission module. We deployed the RPCD-II under a docked fishing vessel at the Ganjiang River in Yangzi Zhou Town Fisheries Village, Nanchang City (8–9 December 2021), where it recorded signals of Yangtze finless porpoise and produced a real-time report. To validate the results of RPCD-II, another underwater sound recorder, the SoundTrap 300HF (ST), was also set up (as a control device) under the docked fishing vessel. Both devices recorded consistent results of 9330 clicks, further demonstrating RPCD-II’s ability for the real-time detection of Yangtze finless porpoise in the field.

Investigation of Energy Losses Induced by Non-Uniform Inflow in a Coastal Axial-Flow Pump - Fan Meng; Yanjun Li; Jia Chen (Journal of Marine Science and Engineering, 2022)
A non-uniform velocity profile occurs at the inlet of a coastal axial-flow pump which is placed downstream of the forebay with side-intake. As a result, the actual efficiency and head of the pump is dissimilar to the design parameters, and the lack of the theoretical investigation on the relationship between inflow distortion and energy losses restricts the application of the coastal axial-flow pump in the drainage project. In this paper, the unsteady numerical simulation and entropy production theory are employed to obtain the internal flow structure and quantify energy losses, respectively, with three inflow deflection angles (θ = 0°, 15°, or 30°). It is reported that the best efficiency point (BEP) shifts to large flow rate with θ increasing, due to the decline of the velocity component in axial direction at the impeller inlet. Therefore, the total entropy production (TEP) of the coastal axial-flow pump rises with θ increasing under small flow rates, but it decreases with θ increasing under large flow rates. The high total entropy production rate (TEPR) in the vicinity of the tailing edge of the impeller and guide vanes rises with θ increasing, caused by the enhanced wake vortex strength. In addition, the high TEPR area near the inlet of outflow conduit rises with θ increasing, originated from the improvement of secondary vortices intensity.

Insights into the characteristics, adsorption and desorption behaviors of microplastics aged with or without fulvic acid - Xiulei Fan; Ya Xie; Shenwen Qian; Yuan Xiang; Qing Chen; YangYang Yang; Jiaqiang Liu; Jiankun Zhang; Jun Hou (Environmental Science and Pollution Research, 2022)

Insulin receptor tyrosine kinase substrate (IRTKS) promotes the tumorigenesis of pancreatic cancer via PI3K/AKT signaling - Yu Lu; Xin-Yuan Zhou; Cheng-Liang Zhou; Jie Liu; Tao Yong; Yong Fan; Chen Wang (Human Cell, 2022)

Mapping of the novel powdery mildew resistance gene Pm2Mb from Aegilops biuncialis based on ph1b-induced homoeologous recombination - Wenqiang Men; Ziwei Fan; Chao Ma; Yue Zhao; Chaoli Wang; Xiubin Tian; Qifan Chen; Jingnan Miao; Jinqiu He; Jiajun Qian; Sunish K. Sehgal; Huanhuan Li; et al. (Theoretical and Applied Genetics, 2022)

Ectopic Expression of Erigeron breviscapus JAZ1 Affects JA-Induced Development Processes in Transgenic Arabidopsis - Mo Chen; Wei Zhang; Mi Yan; Simei He; Yingchun Lu; Guanghui Zhang; Bing Hao; Wei Fan; Yanru Hu; Shengchao Yang (Plant Molecular Biology Reporter, 2022)

Naturally-Occurring Antibodies Against Bim are Decreased in Alzheimer’s Disease and Attenuate AD-type Pathology in a Mouse Model - Jie-Ming Jian; Dong-Yu Fan; Ding-Yuan Tian; Yuan Cheng; Pu-Yang Sun; Cheng-Rong Tan; Gui-Hua Zeng; Chen-Yang He; Ye-Ran Wang; Jie Zhu; Xiu-Qing Yao; Yan-Jiang Wang; et al. (Neuroscience Bulletin, 2022)

Refined-JinQi-JiangTang tablet ameliorates hypertension through activation of FGF21/FGFR1 axis in fructose-fed rats - Siming Li; Xiaoling Li; Jing Fan; Xinhang Jia; Hemeng Wang; Fangxin Dong; Haoyang Mao; Chen Zhang; Wenfei Wang; Ye Jiang; Lijun Yan; Na Zhang (Journal of Natural Medicines, 2022)

Evaluating different metrics from the thermal-based two-source energy balance model for monitoring grapevine water stress - Héctor Nieto; María Mar Alsina; William P. Kustas; Omar García-Tejera; Fan Chen; Nicolas Bambach; Feng Gao; Joseph G. Alfieri; Lawrence E. Hipps; John H. Prueger; Lynn G. McKee; Einara Zahn; et al. (Irrigation Science, 2022)
Precision irrigation management requires operational monitoring of crop water status. However, there is still some controversy on how to account for crop water stress. To address this question, several physiological, several physiological metrics have been proposed, such as the leaf/stem water potentials, stomatal conductance, or sap flow. On the other hand, thermal remote sensing has been shown to be a promising tool for efficiently evaluating crop stress at adequate spatial and temporal scales, via the Crop Water Stress Index (CWSI), one of the most common indices used for assessing plant stress. CWSI relates the actual crop evapotranspiration ET (related to the canopy radiometric temperature) to the potential ET (or minimum crop temperature). However, remotely sensed surface temperature from satellite sensors includes a mixture of plant canopy and soil/substrate temperatures, while what is required for accurate crop stress detection is more related to canopy metrics, such as transpiration, as the latter one avoids the influence of soil/substrate in determining crop water status or stress. The Two-Source Energy Balance (TSEB) model is one of the most widely used and robust evapotranspiration model for remote sensing. It has the capability of partitioning ET into the crop transpiration and soil evaporation components, which is required for accurate crop water stress estimates. This study aims at evaluating different TSEB metrics related to its retrievals of actual ET, transpiration and stomatal conductance, to track crop water stress in a vineyard in California, part of the GRAPEX experiment. Four eddy covariance towers were deployed in a Variable Rate Irrigation system in a Merlot vineyard that was subject to different stress periods. In addition, root-zone soil moisture, stomatal conductance and leaf/stem water potential were collected as proxy for in situ crop water stress. Results showed that the most robust variable for tracking water stress was the TSEB derived leaf stomatal conductance, with the strongest correlation with both the measured root-zone soil moisture and stomatal conductance gas exchange measurements. In addition, these metrics showed a better ability in tracking stress when the observations are taken early after noon.

Application of the vineyard data assimilation (VIDA) system to vineyard root-zone soil moisture monitoring in the California Central Valley - Fan Chen; Fangni Lei; Kyle Knipper; Feng Gao; Lynn McKee; Maria del Mar Alsina; Joseph Alfieri; Martha Anderson; Nicolas Bambach; Sebastian J. Castro; Andrew J. McElrone; Karrin Alstad; et al. (Irrigation Science, 2022)

Household solid fuel use with diabetes and fasting blood glucose levels among middle-aged and older adults in China - Yuxiong Chen; Siqin Feng; Zhen’ge Chang; Yakun Zhao; Jia Fu; Yijie Liu; Siqi Tang; Yitao Han; Yanbo Liu; Yuanxun Zhang; Shuyang Zhang; Zhongjie Fan (Environmental Science and Pollution Research, 2022)

Investigation on the application of by-product steam in iron ore sintering: performance and function mechanism - Yufeng Wu; Xiaohui Fan; Zhiyun Ji; Min Gan; Haoyu Zhou; Haorui Li; Xuling Chen; Yuanjie Zhao; Rongchang Zhang; Ruisi Lai (Environmental Science and Pollution Research, 2022)

Sustainability-oriented system dynamics method for coordinated megacity ecosystem development: the case of Beijing, China - Guojiao Chen; Cuiyou Yao; Lurong Fan; Linze Li; Haiqing Cao (Environment, Development and Sustainability, 2022)

Disciplinary structure of geographic science in China - Fahu Chen; Xin Li; Shaohong Wu; Jie Fan; Juhua Xiong; Guoyou Zhang (Journal of Geographical Sciences, 2022)

Disciplinary structure and development strategy of human geography in China - Jie Fan; Pengjun Zhao; Shangyi Zhou; Xiangzheng Deng; Chen Wang (Journal of Geographical Sciences, 2022)

Establishment of pediatric developmental dysplasia of the hip biobank: Shanghai children’s hospital experience - Dan Yang; Shiqi Wang; Chenghui Ke; Qichao Ma; Lingyan Fan; Yichen Wang; Mengjie Chen; Hao Ying; Sun Wang; Qin Jiao; Yang Shen; Lihua Zhao (Cell and Tissue Banking, 2022)
Developmental dysplasia of the hip (DDH) is a debilitating condition that affects 1–7% of newborns. Children with DDH, not treated early and effectively, will easily lead to disability. A better understanding of the biology of DDH is critical to the development of prognostic biomarkers and novel therapies. The purpose of this study was to establish a biobank of DDH genetic resources, to facilitate clinical and basic scientific research. The biological specimen and clinical data of DDH were collected in Shanghai Children’s Hospital from 2014 to 2021. The collection of blood samples was performed at definitive diagnosis and review, tissue specimens were performed at definitive surgery. The clinical data was collected at the whole stage of DDH patients at diagnosis, treatment and follow-up. A total of 528 patients with DDH were enrolled in this study, 90 were men and 438 were women, with the mean age of 4.67 years. The numbers of tissue and blood specimens reached 2172 and 1490, respectively. The quality test results showed that the DNA concentration decreased slightly with the extension of storage time, but the DNA purity did not change. Meanwhile, the extension of storage time slightly affected the stability of protein of tissue samples but did not affect the expression of the housekeeping gene. The DDH biobank built has the potential of monitoring disease pathogenesis and progress, which could provide specimens to the researchers improving the biological understanding and provide guidance of clinical treatment of this disease to clinicians.

Moisture sources for the weather pattern classified extreme precipitation in the first rainy season over South China - Fan Xin; Dongdong Peng; Run Liu; Shaw Chen Liu (International Journal of Climatology, 2022)
Moisture transport, associated with moisture sources and synoptic‐scale weather conditions, is a key dynamic process of precipitation events. Using the K ‐means clustering method and the FLEXPART Lagrangian particle dispersion model, this paper investigates moisture contributions from different source regions to extreme precipitation in the first rainy season (hereafter FRS) over South China. In average, land regions contribute more to the FRS extreme precipitation over South China than the ocean regions. The main source regions are Southeast Asia (22.7%), South China (17.2%), the South China Sea (14.3%), and the Bay of Bengal (8.3%). Extreme precipitation events are classified into three types by the K ‐means clustering based on 850 hPa geopotential height, which are all characterized by an anomalous low‐pressure system over South China with varying intensity and locations. The distribution of geopotential height anomaly for Type I (30.3%) is characterized the low trough extending from Japan to South China, while Type II (42.5%) and Type III (27.2%) are characterized by “west negative–east positive” and “north positive–south negative” patterns over East Asia with anomalous cyclone over South China, respectively. The much larger contribution of land sources than ocean regions are mainly concentrated in Type I and Type III, of which the contribution from each source region is similar. Ocean sources play a more important role in Type II and are mainly from the Indian Ocean (16.2%) associated with the onset of South China Sea summer monsoon.

Global evaluation of inhibitor impacts on ammonia and nitrous oxide emissions from agricultural soils: A meta‐analysis - Daijia Fan; Wentian He; Ward N. Smith; Craig F. Drury; Rong Jiang; Brian B. Grant; Yaoyao Shi; Daping Song; Yanhua Chen; Xuexia Wang; Ping He; Guoyuan Zou (Global Change Biology, 2022)
Inhibitors are widely considered an efficient tool for reducing nitrogen (N) loss and improving N use efficiency, but their effectiveness is highly variable across agroecosystems. In this study, we synthesized 182 studies (222 sites) worldwide to evaluate the impacts of inhibitors (urease inhibitors [UI], nitrification inhibitors [NI] and combined inhibitors) on crop yields and gaseous N loss (ammonia [NH 3 ] and nitrous oxide [N 2 O] emissions) and explored their responses to different management and environmental factors including inhibitor application timing, fertilization regime, cropping system, water management, soil properties and climatic conditions using subgroup meta‐analysis, meta‐regression and multivariate analyses. The UI were most effective in enhancing crop yields (by 5%) and reducing NH 3 volatilization (by 51%), whereas NI were most effective at reducing N 2 O emissions (by 49%). The application of UI mitigates NH 3 loss and increases crop yields especially in high NH 3 ‐N loss scenarios, whereas NI application would minimize the net N 2 O emissions and the resultant environmental impacts especially in low NH 3 ‐N loss scenarios. Alternatively, the combined application of UI and NI enables producers to balance crop production and environmental conservation goals without pollution tradeoffs. The inhibitor efficacy for decreasing gaseous N loss was dependent upon soil and climatic conditions and management practices. Notably, both meta‐regression and multivariate analyses suggest that inhibitors provide a greater opportunity for reducing fertilizer N inputs in high‐N‐surplus systems and presumably favor crop yield enhancement under soil N deficiency situations. The pursuit of an improved understanding of the interactions between plant‐soil‐climate‐management systems and different types of inhibitors should continue to optimize the effectiveness of inhibitors for reducing environmental losses while increasing productivity.

Exploring the Spatial and Temporal Distribution of Frigate Tuna (Auxis thazard) Habitat in the South China Sea in Spring and Summer during 2015–2019 Using Fishery and Remote Sensing Data - Xingxing Zhou; Zuozhi Chen; Pengli Xiong; Yancong Cai; Jie Li; Peng Zhang; Jun Zhang; Miao Li; Jiangtao Fan (Fishes, 2022)
Frigate tuna Auxis thazard fishery is considered a potential marine resource in the open South China Sea (SCS). However, little is known about the spatial and temporal distribution of its habitat, and how this may respond to environmental changes. Using fish survey and remote sensing data from 2015–2019, we applied generalized additive models to identify relationships between environmental factors and the distribution of A. thazard in the SCS. To examine seasonal patterns in the habitat of A. thazard in the SCS, we generated a habitat suitability index model using environmental factors screened by generalized additive models. Results showed that A. thazard migrates from south to north in the SCS, and its suitable habitat is patchily distributed. Significant environmental factors affecting the habitat of A. thazard distribution were different in different seasons; we demonstrated A. thazard to be sensitive to Chl-a in spring (optimum 0.155, optimal range ~0.1252–0.1840), and in summer to be sensitive to SST (optimum 30.405, optimal range ~29.789–31.021) and SSH (optimum 0.741, optimal range ~0.618–0.864). Suitable habitat in spring occurs mainly in northeastern areas, while in summer it occurs mainly around the southeastern Nansha Islands. Compared with that in spring, the area of suitable habitat increases in summer, as does the habitat suitability index of the entire sea area. These results improve our understanding of environmental factors that affect the distribution of A. thazard habitat in the SCS, and provide a scientific basis for the development and management of A. thazard resources.

PTEN-induced kinase 1 enhances the reparative effects of bone marrow mesenchymal stromal cells on mice with renal ischaemia/reperfusion-induced acute kidney injury - Chenyu Lin; Wen Chen; Yong Han; Yujie Sun; Xiaoqiong Zhao; Yuan Yue; Binyu Li; Wenmei Fan; Tao Zhang; Li Xiao (Human Cell, 2022)
Acute kidney injury (AKI) is a common severe acute syndrome caused by multiple factors and is characterized by a rapid decline in renal function during a short period. Bone marrow mesenchymal stromal cells (BMSCs) are effective in treating AKI. However, the mechanism of their beneficial effects remains unclear. PTEN-induced kinase 1 (PINK1) may play an important role in kidney tissue repair. In this study, we explored the effect of PINK1 overexpression on enhancing BMSC-mediated repair of AKI. In this study, ischaemia/reperfusion-induced AKI (IRI-AKI) in mice and a hypoxia-reoxygenation model in cells were established, and the indices were examined by pathology and immunology experiments. After ischaemia/reperfusion, PINK1 overexpression reduced apoptosis in injured kidney tissue cell, decreased T lymphocyte infiltration, increased macrophage infiltration, and alleviated the inflammatory response. PINK1 relieved the stress response of BMSCs and renal tubular epithelial cells (RTECs), reduced apoptosis, altered the release of inflammatory factors, and reduced the proliferation of peripheral blood mononuclear cells (PBMCs). In conclusion, BMSCs and RTECs undergo stress responses in response to hypoxia, inflammation and other conditions, and overexpressing PINK1 in BMSCs could enhance their ability to resist these stress reactions. Furthermore, PINK1 overexpression can regulate the distribution of immune cells and improve the inflammatory response. The regulation of mitochondrial autophagy during IRI-AKI maintains mitochondrial homeostasis and protects renal function. The results of this study provide new strategies and experimental evidence for BMSC-mediated repair of IRI-AKI.

Archives of short-term fluid flow dynamics and possible influence of human activities at methane seeps: Evidence from high-resolution element geochemistry of chemosynthetic bivalve shells - Xudong Wang; Danling Fan; Steffen Kiel; Shanggui Gong; Qiangyong Liang; Jun Tao; Duofu Chen; Dong Feng (Frontiers in Marine Science, 2022)
The natural dynamics of fluid flow at methane seeps and increasingly human activities influence the biogeochemistry of the microenvironment and further determine the activity of the chemosynthetic communities within these ecosystems. However, ways to reconstruct short-term fluid flow dynamics and to decipher the influence of scientific exploration at seeps are limited. In this study, we present high-resolution trace elements/Ca ratios (Li/Ca, Mg/Ca, Ti/Ca, Mn/Ca, Co/Ca, Cu/Ca, Zn/Ca, Sr/Ca, Zr/Ca, Mo/Ca, Ba/Ca, Th/Ca and U/Ca ratios) from the shells of two species of chemosymbiotic bivalves (the thiotrophic vesicomyid clam Archivesica marissinica and the methanotrophic mussel Gigantidas haimaensis ) from the Haima cold seeps of the South China Sea. We found that the complex distribution patterns of some trace elements (Mg/Ca, Sr/Ca, Mo/Ca and U/Ca ratios) in G. haimaensis are largely controlled by mineral composition or age. The observation of Co/Ca and Ba/Ca ratios in both species indicate strong physiological and environmental control on the incorporation of trace elements during the biomineralization process. Besides, the distribution patterns of other trace elements provide information that can be used to discuss open issues such as the loss of trace elements after death of the bivalves, and the possible influence of human activities such as sediment disturbance. Overall, this study emphasizes the potential for using high-resolution element geochemistry of seep bivalve shells to reveal the physiological and environmental factors that control the growth of bivalves, and to elucidate the potential history of fluid discharge at cold seeps.

Genome-wide association study of SARS-CoV-2 infection in Chinese population - Jie Fan; Quan-Xin Long; Ji-Hua Ren; Hao Chen; Meng-Meng Li; Zheng Cheng; Juan Chen; Li Zhou; Ai-Long Huang (European Journal of Clinical Microbiology & Infectious Diseases, 2022)

Dolominol a and B, two new neolignans from Dolomiaea souliei (Franch.) C.Shih - Man Yi; Fan-Cheng Meng; Shen-Yue Qu; Jing-Xin Mao; Guowei Wang; Mingxing Liu; Zhi-Hua Liao; Min Chen (Natural Product Research, 2022)

Retraction Note to: Exosomes derived from bone mesenchymal stem cells attenuate myocardial fibrosis both in vivo and in vitro via autophagy activation: the key role of miR-199a-3p/mTOR pathway - Chenrong Fan; Qizeng Wang; Youjin Chen; Tingting Ye; Yuncao Fan (Human Cell, 2022)

Human Umbilical Cord-Derived Mesenchymal Stem Cells Ameliorate Skin Aging of Nude Mice Through Autophagy-Mediated Anti-Senescent Mechanism - Ting Li; Li Zhou; Mengqiang Fan; Zuxiang Chen; Li Yan; Haishan Lu; Ming Jia; Huiling Wu; Letian Shan (Stem Cell Reviews and Reports, 2022)

Cellular Heterogeneity Facilitates the Functional Differences Between Hair Follicle Dermal Sheath Cells and Dermal Papilla Cells: A New Classification System for Mesenchymal Cells within the Hair Follicle Niche - Yuyang Gan; Hailin Wang; Lijuan Du; Kaitao Li; Qian Qu; Weiwen Liu; Pingping Sun; Zhexiang Fan; Jin Wang; Ruosi Chen; Zhiqi Hu; Yong Miao (Stem Cell Reviews and Reports, 2022)

A Hybrid Logistic Regression: Gene Expression Programming Model and Its Application to Mineral Prospectivity Mapping - Fan Xiao; Weilin Chen; Jun Wang; Oktay Erten (Natural Resources Research, 2022)

Mineral Prospectivity Mapping based on Isolation Forest and Random Forest: Implication for the Existence of Spatial Signature of Mineralization in Outliers - Shuai Zhang; Emmanuel John M. Carranza; Keyan Xiao; Hantao Wei; Fan Yang; Zhenghui Chen; Nan Li; Jie Xiang (Natural Resources Research, 2022)

Investigation and experimental validation of curcumin-related mechanisms against hepatocellular carcinoma based on network pharmacology - Yang Chen; Qian Li; Sisi Ren; Ting Chen; Bingtao Zhai; Jiangxue Cheng; Xiaoyan Shi; Liang Song; Yu Fan; Dongyan Guo (Journal of Zhejiang University-SCIENCE B, 2022)

Knockdown of Chk1 inhibits proliferation and promotes apoptosis in mouse granulosa cells and its regulation mechanism by miR-15a and miR-16 - Xiao-Ming Liu; Fang Chen; Fan Zhang; Hai-Tao Xi; Jun-Zhao Zhao (In Vitro Cellular & Developmental Biology - Animal, 2022)

Feed types affect the growth, nutrient utilization, digestive capabilities, and endocrine functions of Megalobrama amblycephala: a comparative study between pelleted and extruded feed - Chao-Fan He; Xiang-Fei Li; Guang-Zhen Jiang; Ling Zhang; Miao Sun; Ya-Ping Ge; Wei-Liang Chen; Wen-Bin Liu (Fish Physiology and Biochemistry, 2022)

Association of caffeine and caffeine metabolites with obesity among children and adolescents: National Health and Nutrition Examination Survey (NHANES) 2009–2014 - Linling Yu; Hong Mei; Da Shi; Xing Wang; Man Cheng; Lieyang Fan; Yang Xiao; Ruyi Liang; Bin Wang; Meng Yang; Weihong Chen (Environmental Science and Pollution Research, 2022)

High removal of nitrogen and phosphorus from black-odorous water using a novel aeration-adsorption system - Guocheng Zhu; Junming Chen; Shanshan Zhang; Zilong Zhao; Huihao Luo; Andrew S. Hursthouse; Peng Wan; Gongduan Fan (Environmental Chemistry Letters, 2022)
Black-odorous waters are an increasingly common phenomenon characterized by excessive levels of nutrients, the formation of metal sufide precipitates, volatile sulfurous compounds, low dissolved oxygen and high chemical oxygen demand. Black-odorous waters frequently occur in lake and river systems where inputs have restricted circulation. The key remediation issue is the removal of nitrogen and phosphorus. Here, we present a novel aeration-adsorption system using fiber balls and we study treatment parameters and removal mechanism. Kinetics and changes of the solid phase were followed using Fourier transform infrared spectroscopy, X-ray photoelectron spectroscopy, and X-ray diffraction. Results show complete removal of ammonia N, initially at 31 mg/L, and 92.8% removal of total nitrogen, initially at 29 mg/L, after a 24 h reaction time at pH 9.67. At pH 5.67 and 9.67, total phosphorus and phosphate could be significantly reduced by 90–92% at 3.2–5.2 mg/L after 24 h. Treatment met China’s integrated wastewater discharge standards, demonstrating an effective and robust treatment capability. First-order and second-order kinetic models provided a good fit to the treatment data, indicating physical and chemical adsorption were involved in the treatment reactions. The reaction mechanism involved hydrogen substitution and binding to oxygen. These results present a cost effective and robust approach for the removal of N and P from black, odorous water, providing opportunity to abate environmental contamination.

History of suicide attempts associated with the thinning right superior temporal gyrus among individuals with schizophrenia - Yi Yin; Jinghui Tong; Junchao Huang; Baopeng Tian; Song Chen; Shuping Tan; Zhiren Wang; Fude Yang; Yongsheng Tong; Fengmei Fan; Peter Kochunov; Neda Jahanshad; et al. (Brain Imaging and Behavior, 2022)

Deep learning based diagnosis of Parkinson’s Disease using diffusion magnetic resonance imaging - Hengling Zhao; Chih-Chien Tsai; Mingyi Zhou; Yipeng Liu; Yao-Liang Chen; Fan Huang; Yu-Chun Lin; Jiun-Jie Wang (Brain Imaging and Behavior, 2022)

PRMT6/LMNA/CXCL12 signaling pathway regulated the osteo/odontogenic differentiation ability in dental stem cells isolated from apical papilla - Ning Wang; Miao Li; Yangyang Cao; Haoqing Yang; Le Li; Lihua Ge; Zhipeng Fan; Chen Zhang; Luyuan Jin (Cell and Tissue Research, 2022)

Pottery circulation and cultural exchange during the mid-late Neolithic Age in the northeastern Tibetan Plateau - Xiaoliang Chen; Guangliang Hou; Qishun Fan; Youcheng Chen; Zhuoma Wende; Zhuoma Lancuo; Jingyi Gao (Archaeological and Anthropological Sciences, 2022)

MdMYB88/124 modulates apple tree microRNA biogenesis through post-transcription processing and/or transcription pathway - Chun-dong Niu; Huan-ran Shi; Zi-tong Zhang; Tian-le Fan; Huan Dang; Peng-xiang Chen; Yin-peng Xie; Cha-na Bao; Feng-wang Ma; Qing-mei Guan; Xue-wei Li (Acta Physiologiae Plantarum, 2022)

Assessing trophic interactions among three tuna species in the Solomon Islands based on stomach contents and stable isotopes - Ri Jin Jiang; Fan Yang; Feng Chen; Rui Yin; Ming Zhi Liu; Wen Bin Zhu; Ai Guo; Lian Wei Liu (Frontiers in Marine Science, 2022)
Trophic research is essential to the conservation and management of fishery resources. This study analyzed the feeding habits and nutritional interactions among three tuna species in the waters of the Solomon Islands (5°12′S–15°20′S, 157°31′E–172°19′E). A total of 103 bigeye tuna ( Thunnus obesus ), 296 yellowfin tuna ( Thunnus albacores ), and 264 albacore tuna ( Thunnus alalunga ) samples were collected from September to December 2019. Samples for stomach content and stable isotope analysis were randomly selected. The stomach content analysis results showed that the stomach contents of the three tuna species were rich in prey, and 48 prey species were identified, including fish, cephalopods, and crustaceans, with high between-phenotype component (BPC). Yellowfin tuna consumed the largest variety of food and bigeye tuna consumed the smallest. The feeding intensity of bigeye tuna were higher than that of yellowfin and albacore tuna. Yellowfin tuna had the highest empty stomach rate (35.69%) and lowest average stomach fullness index (0.064). The degree of stomach fullness in the three tuna species was mainly 1, and the difference in the stomach fullness index among them was significant ( P <0.001). Food overlap (0.3–0.6) and Levins index (<0.6) among the three species were low, indicating a specialized feeding tendency. Bigeye tuna mainly feed on Ommastrephes bartrami and Myctophidae, yellowfin tuna mainly feed on Hyperiidea and Aluterus monoceros , and albacore tuna mainly feed on Gempylus serpens and Loligo chinensis . The stable isotope results showed that the δ 13 C and δ 15 N values of the three tuna species were significant ( P <0.001). The standard ellipse area corrected for small sample sizes (SEAc) and total niche area (TA) of bigeye tuna, range of δ 15 N (NR) of yellowfin tuna, and range of δ 13 C (CR) of albacore tuna were the highest. The results of this study will help improve our understanding of the feeding ecology of these three tuna species and their important roles in the ecosystem and food web structure.

Anti-Inflammatory Effect of Acetone Extracts from Microalgae Chlorella sp. WZ13 on RAW264.7 Cells and TPA-induced Ear Edema in Mice - Longhe Yang; Fan Hu; Yajun Yan; Siyu Yu; Tingting Chen; Zhaokai Wang (Frontiers in Marine Science, 2022)
Microalgae extracts have a wide range of uses in the field of healthcare and nutrition. However, the use of microalgae extracts in anti-inflammatory properties and their mechanism of action have not yet been fully studied. Here, we show that extracts from Chlorella sp. WZ13 (CSE-WZ13) dose-dependently reduced nitrite production, inhibited the expression of inducible nitric oxide synthase (iNOS) protein, and decreased the production of the gene and inflammatory cytokines tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6), in lipopolysaccharide (LPS)-stimulated RAW264.7 cells. Using high-content imaging analysis, it was found that CSE-WZ13 inhibited the translocation of nuclear factor kappa B (NF-κB) from the cytoplasm to the nucleus. CSE-WZ13 also exerted anti-inflammatory effects in an ear edema mouse model induced by 12-O-tetradecanoylphorbol-13-acetate (TPA). CSE-WZ13 inhibited edema by 36.17% and 25.66% at a dose of 0.3 and 0.1 mg/ear, respectively. Histological analysis showed that topical application of CSE-WZ13 decreased TPA-induced inflammatory cell infiltration. Our results indicate that CSE-WZ13 may be a useful candidate for the purpose of decreasing inflammation.

Dynamic Evolution and Identification of Bed Separation in Overburden During Coal Mining - Kaifang Fan; Jianghui He; Wenping Li; Weichi Chen (Rock Mechanics and Rock Engineering, 2022)

A review of seismo-electromagnetic research in China - Guoze Zhao; Xuemin Zhang; Juntao Cai; Yan Zhan; Qinzhong Ma; Ji Tang; Xuebin Du; Bing Han; Lifeng Wang; Xiaobin Chen; Qibin Xiao; Xiangyu Sun; et al. (Science China Earth Sciences, 2022)

Variable responses to chronic and acute elevated temperature of three coral species from reefs with distinct thermal regimes - Crystal J. McRae; Shashank Keshavmurthy; Pei-Jie Meng; Sabrina L. Rosset; Wen-Bin Huang; Chaolun Allen Chen; Tung-Yung Fan; Isabelle M. Côté (Marine Biology, 2022)

The impacts of ambient relative humidity and temperature on supine position-related obstructive sleep apnea in adults - Wen-Te Liu; Yuan-Hung Wang; Li-Te Chang; Chih-Da Wu; Dean Wu; Cheng-Yu Tsai; Chen-Chen Lo; Kang Lo; Kian Fan Chung; Ta-Yuan Chang; Kai-Jen Chuang; Yueh-Lun Lee; et al. (Environmental Science and Pollution Research, 2022)

Microbial composition and nitrogen removal pathways in a novel sequencing batch reactor integrated with semi-fixed biofilm carrier: evidence from a pilot study for low- and high-strength sewage treatment - Peng-fei Chen; Rui-jian Zhang; Zhi-li Du; Guang-hua Wang; Hao-tao Dong; Bin Cui; Ru-pei Fan; Lu-xin Li; Qian-bin Wang; Ying-shi Liu; Zhi-min Sun (Environmental Science and Pollution Research, 2022)

Dynamics of antibiotic resistance genes and microbial community in shortcut nitrification–denitrification process under antibiotic stresses - Chong Yang; Lin Wang; Huan Wang; Hongyan Zhang; Fan Wang; Houzhen Zhou; Zhouliang Tan; Yangwu Chen (Environmental Science and Pollution Research, 2022)

Extracting tea plantations in complex landscapes using Sentinel-2 imagery and machine learning algorithms - Panpan Chen; Chunjiang Zhao; Dandan Duan; Fan Wang (Community Ecology, 2022)

Fabrication of Polyaluminium Ferric Sulfate from Bauxite Residue for Efficient Removal of Cr(VI) from Simulated Wastewater - Zhiqiang Lan; Si Wan; Runhua Chen; Yangyang Wang; Cuiyu Yuan; Ke Fan; Xikai Xu (Bulletin of Environmental Contamination and Toxicology, 2022)

Equation of state of elbaite at high pressure up to 21.1 GPa and room temperature - Wei Chen; Shijie Huang; Zhilin Ye; Jiamei Song; Shanrong Zhang; Mengzeng Wu; Dawei Fan; Wenge Zhou (Physics and Chemistry of Minerals, 2022)

The functional evolution and system equilibrium of urban and rural territories - Jie Fan; Sisi Li; Zhongrui Sun; Rui Guo; Kan Zhou; Dong Chen; Jianxiong Wu (Journal of Geographical Sciences, 2022)

Comprehensive analysis of TCR repertoire of COVID-19 patients in different infected stage - Guangyu Wang; Yongsi Wang; Shaofeng Jiang; Wentao Fan; Chune Mo; Weiwei Gong; Hui Chen; Dan He; Jinqing Huang; Minglin Ou; Xianliang Hou (Genes & Genomics, 2022)

Streptococcus vulneris sp. nov., isolated from wound of patient with diabetic foot ulcer (DFU) - Jen-hao Chung; Li-Ting Wang; Yi-Sheng Chen; Yun-Shien Lee; Shih-Ting Lin; Yu-Chung Chang; Hui-Chung Wu; Yu-Jie Dai; Wei-Qi Liao; Fan-Ching Kao; Jui-hsiang Li (Archives of Microbiology, 2022)

Electrospun Polysaccharides for Periodontal Tissue Engineering: A Review of Recent Advances and Future Perspectives - Jiao Wang; Yi Chen; Jialing Li; Zhen Chen; Min Fan; Fanjing Lin; Yonglin Xie (Annals of Biomedical Engineering, 2022)

Discovery of the non‐cosmopolitan lineages in Candidatus Thermoprofundales - Yi‐Fan Liu; Liu Yang; Zhong‐Lin Liu; Jing Chen; Bo Fang; Lei Zhou; Jin‐Feng Liu; Shi‐Zhong Yang; Ji‐Dong Gu; Bo‐Zhong Mu (Environmental Microbiology, 2022)
Summary The recently proposed order Candidatus Thermoprofundales, currently containing only one family‐level lineage Marine Benthic Group‐D (MBG‐D), is distributed in global subsurface ecosystems and ecologically important, but its diversity, evolution and metabolism remain largely unknown. Here we described two novel family‐level specialized lineages in Ca . Thermoprofundales, JdFR‐43 and HyVt, which are restricted to specific biotopes (primarily in marine hydrothermal vents and occasionally in oil reservoirs and hot springs) in contrast to the cosmopolitan lineage MBG‐D. The comparative genomics revealed that the specialized lineages have streamlined genomes, higher GC contents, enriched genes associated with nucleotide biosynthesis, ribosome biogenesis and DNA repair and additional thermostable aminopeptidases, enabling them to adapt to high‐temperature habitats such as marine hydrothermal vents, deep subsurface oil reservoirs and hot springs. On the contrary, the unique metabolic traits of the cosmopolitan MBG‐D, motility, glycolysis, butanoate metabolism, secondary metabolites production and additional genes for specific peptides and carbohydrates degradation potentially enhance its response to environmental change. Substrate preference is found for most MAGs across all lineages with the ability to utilize both polysaccharides (chitin and starch) and proteinaceous substances, whereas JdFR‐43 members from oil reservoirs can only utilize proteins. These results expand the diversity of C a . Thermoprofundales significantly and further improve our understandings of the adaptations of C a . Thermoprofundales to various environments.

Development and perspectives of rapid detection technology in food and environment - Xue-Xia Jia; Shuang Li; Dian-Peng Han; Rui-peng Chen; Zi-Yi Yao; Bao-an Ning; Zhi-Xian Gao; Zhen-Chuan Fan (Critical Reviews in Food Science and Nutrition, 2022)

Metagenomic analysis of the microbiome of the upper reproductive tract: combating ovarian cancer through predictive, preventive, and personalized medicine - Xu Qin; Jianglin Zhou; Zizhuo Wang; Chenzhao Feng; Junpeng Fan; Jia Huang; Dianxing Hu; Babak Baban; Shengqi Wang; Ding Ma; Chaoyang Sun; Zhe Zhou; et al. (EPMA Journal, 2022)
Purpose We investigated whether ovarian cancer could alter the genital microbiota in a specific way with clinical values. Furthermore, we proposed how such changes could be envisioned in a paradigm of predictive, preventive, and personalized medicine (PPPM). Methods The samples were collected using cotton swabs from the cervical, uterine cavity, fallopian tubes, and ovaries of patients subjected to the surgical procedures for the malignant/benign lesions. All samples were then analyzed by metagenomic shotgun sequencing. The distribution patterns and characteristics of the microbiota in the reproductive tract of subjects were analyzed and were interpreted in relation to the clinical outcomes of the subjects. Results While the ovarian cancer was able to alter the genital microbiota, the bacteria were the dominant microorganisms in all samples across all cohorts in the study (median 99%). The microbiota of the upper female reproductive tract were mainly from the cervical, identified by low bacterial biomass and high bacterial diversity. Ovarian cancer had a distinct microbiota signature. The tubal ligation affects its microbial distribution. There were no different species on the surface of platinum-sensitive ovarian tissues compared to samples from platinum-resistant patients. Conclusion The ovarian cancer–induced changes in microbiota magnify the potential of microbiota as a biotherapeutic modality in the treatment of ovarian cancer in this study and very likely for several malignancies and other conditions. Our findings demonstrated, for the first time, that microbiota could be dissected and applied in more specific fashion based on a predictive, preventive, and personalized medicine (PPPM) model in the treatment of ovarian cancer. Utilizing microbiota portfolio in a PPPM system in ovarian cancer would provide a unique opportunity to a clinically intelligent and novel approach in the treatment of ovarian cancer as well as several other conditions and malignancies.

Diversity and Structure of Demersal Fish Community Over the Northern Slope in the South China Sea - Jun Zhang; Kui Zhang; Yan-e Jiang; Yuan-jie Li; Jiang-tao Fan; Wen-ming Yu; Zuo-zhi Chen (Frontiers in Marine Science, 2022)
Three bottom trawl surveys over the northern continental slope in the South China Sea (18°50′–20°40′N, 112°50′–115°10′E) were carried out, in June 2015, March 2017 and September 2018, to investigate species composition, biodiversity and community structure of demersal fish. Surveys in 2015, 2017 and 2018 captured 97 fish species (representing 77 genera, 52 families, 26 orders), 108 fish species (representing 84 genera, 61 families, 19 orders) and 126 fish species (representing 105 genera, 74 families, 25 orders), respectively. Three surveys captured a total of 252 fish species, representing 164 genera, 97 families, 30 orders. Perciformes dominated. Species richness in station linking shallow continental shelf with deep slope was the lowest among stations. In three surveys, 16 species occurred in the catches of three surveys, accounting for 6.35% of all species. Species replacement rate between stations showed a significant linear relationship with the depth difference and latitude difference. Margalef’s species richness index ( D ), Shannon–Weiner diversity index ( H’ ) and Pielou’s evenness index ( J’ ) among stations ranged 2.65–6.74, 1.02–4.15 and 0.28–1.14, respectively. Differences of D , H ’ and J ’ were insignificant among seasons. There were significant positive linear relations between H’ and J’ and latitude. D , H’ and J’ decreased with increasing sampling depth, however the relations were not significant. Based on multivariate statistical analysis, fish community at species level was divided into five groups with average dissimilarities of 95.69%–99.96%. In terms of genus and family, average dissimilarities among groups were more than 88.11% and 82.69%. There were significant differences in species composition between depths, but no significant differences between seasons and temperatures, as well as in genus and family composition.

Molecular Characterization and Expression Analysis of Glutaredoxin 5 in Black Tiger Shrimp (Penaeus monodon) and Correlation Analysis Between the SNPs of PmGrx5 and Ammonia-N Stress Tolerance Trait - Rui Fan; Shigui Jiang; Yundong Li; Qibin Yang; Song Jiang; Jianhua Huang; Lishi Yang; Xu Chen; Falin Zhou (Frontiers in Marine Science, 2022)
Glutaredoxins (Grxs) are glutathione-dependent oxidoreductases that belong to the thioredoxin (Trx) superfamily and are an essential part of the redox system in living organisms. However, there is a serious lack of sequence information and functional validation associated with Grxs in crustaceans. In this study, a new Grx gene ( PmGrx5 ) was identified and characterized in black tiger shrimp ( Penaeus monodon ). The full-length cDNA of PmGrx5 is 787 bp and consists of 114 bp 5′-UTR, 232 bp 3′-UTR, and 441 bp ORF, encoding a hypothetical protein of 146 amino acids. The putative PmGrx5 protein is 16.27 kDa with a theoretical isoelectric point of 5.90. Sequence alignment showed that PmGrx5 had the highest amino acid sequence homology with Grx5 from Penaeus vannamei at 98.63% and clustered with Grx5 from other crustaceans. Quantitative real-time PCR (qRT-PCR) analysis showed that PmGrx5 was expressed in all tissues examined, with a higher expression in the testis, stomach, lymphoid organ, and gill. PmGrx5 was continuously expressed during development, with the highest expression in zoea I. Ammonia-N stress and bacterial infection both differentially upregulated PmGrx5 expression in the hepatopancreas and gill. In addition, when PmGrx5 was inhibited, the expression of some other antioxidant enzymes was upregulated at the beginning of ammonia-N stress, but as the stress time increased, the expression of antioxidant enzymes was inhibited, the expression of apoptotic genes was increased, and the GSH content was significantly reduced. Inhibition of PmGrx5 led to a greater risk of oxidative damage in shrimp. In addition, the relationship between SNPs in exons of the PmGrx5 gene and tolerance to ammonia-N stress was identified and analysed. A total of nine SNPs were successfully identified, eight of which were significantly associated with ammonia and nitrogen stress tolerance trait in shrimp ( P < 0.05). The present study shows that PmGrx5 is involved in redox regulation and plays an important role in shrimp resistance to marine environmental stresses. Meanwhile, this study will provide a basis for molecular marker breeding in shrimp.

Protective effects of scutellarin on acute alcohol gastric injury - Feixue Liu; Yan Wang; Babatunde Kazeem Bello; Hui Fan; Gang Liu; Xiao Zhang; Tianmeng Zhang; Zibo Dong; Xin Feng; Yi Chen; Daoyang Teng; Jingquan Dong (Biologia, 2022)

Hasubanan alkaloids with anti-inflammatory activity from Stephania longa - Hui Liu; Wan-Qin Liao; Rong-Xiao Lin; Lixia Fan; Jinyan Sun; Hong-Yuan Chen; Fang Liu; An-Ping Yang (Natural Product Research, 2022)

Biotransformation of ursolic acid by Circinella muscae and their anti-neuroinflammatory activities of metabolites - Chengjiao Chu; Kainan Song; Yongzhen Zhang; Min Yang; Boyi Fan; Huilian Huang; Guangtong Chen (Natural Product Research, 2022)

Otolith Marking With Strontium for Stock Assessment in Coilia nasus - Ming-Zhi Liu; Ri-jin Jiang; Hui Zhang; Fan Yang; Xia-Fang Li; Guang-Peng Feng; Rui Yin; Feng Chen (Frontiers in Marine Science, 2022)
Mass stock enhancement and release are excellent ways to recover Coilia nasus resources. However, it is challenging to evaluate stock enhancement effectively, and it is important to establish a method suitable for estimating C. nasus populations. We explored the effectiveness of marking otoliths in these fish with strontium by immersing C. nasus in hexahydrate strontium chloride solutions. We used laser ablation inductively coupled plasma mass spectrometry to measure the strontium content of otoliths and fish bodies. The larvae (40 d post hatch) were reared in five different concentrations of strontium (0, 12, 24, 48, and 60 mg/L) for 7 d, followed by treatment in non-additive water for 3 wk. The results showed that the cumulative mortality rate was not significantly different between treatment and control groups ( P >0.05), except in the group treated with 24 mg/L strontium. The swimming and feeding behaviors did not change significantly, indicating that strontium did not negatively affect survival in this species. The strontium/calcium ratios of otoliths in the control group were stable (1.78–2.32 mmol/mol), whereas those of the experimental (marked) groups ranged widely (4.47–61.02 mmol/mol). The strontium/calcium ratios increased with increasing strontium concentration, but gradually returned to baseline values, resulting in a 100% success rate of marking with strontium. Following immersion in 12 mg/L strontium, strontium levels in the body returned to normal after 24 d. In summary, a treatment of 12 mg/L strontium for 4 d was identified as viable for marking. We confirmed the feasibility of strontium marking for the mass marking and release of C. nasus . This marking method does not affect the physiology of the fish and may provide a new approach for reasonable and scientific stock assessment of C. nasus post hatch.

LncRNA TARID induces cell proliferation through cell cycle pathway associated with coronary artery disease - Zheng Cheng; Yonghong Zhang; Yang Zhuo; Jie Fan; Ying Xu; Mengmeng Li; Hao Chen; Li Zhou (Molecular Biology Reports, 2022)

Kaempferol suppresses androgen-dependent and androgen-independent prostate cancer by regulating Ki67 expression - Yimin Zhang; Jingqin Chen; Wenxuan Fang; Kaoyun Liang; Xiaoning Li; Fan Zhang; Yuzhou Pang; Gang Fang; Xueni Wang (Molecular Biology Reports, 2022)

Effects of indoor culture conditions on growth and phycoerythrin content of Proteomonas sulcata (Cryptophyta) assessed by flow cytometry - Boryuan Chen; Han-Yang Yeh; Chih-Hsien Huang; Wei Qing Chloe Lung; Yi-Jung Chen; Po-Tsang Lee; Fan-Hua Nan; Meng-Chou Lee (Journal of Applied Phycology, 2022)

Field engineering application of agricultural farmland surface runoff pollution treatment by combined bioreactor and constructed wetlands - H. Luo; X. Li; Y. Chen; X. Liu; K. Zhang; X. Fu; B. Jiang; R. Xue; J. Yang; M. Li; X. Li; W. Chen; et al. (International Journal of Environmental Science and Technology, 2022)

Chronology, geochemical characteristics, and tectonic implications of a Triassic complex in the Rongma Area, Southern Qiangtang, Tibet - Zheng-Zhe Fan; Quan Wang; Xian Chen; Gen-Hou Wang; Yue Fu; Gui-Juan Guo (International Journal of Earth Sciences, 2022)

Construction of single, double, or triple mutants within kojic acid synthesis genes kojA, kojR, and kojT by the CRISPR/Cas9 tool in Aspergillus oryzae - Yuzhen Li; Huanxin Zhang; Ziming Chen; Junxia Fan; Tianming Chen; Bin Zeng; Zhe Zhang (Folia Microbiologica, 2022)

Effects of phosphorus-containing material application on soil cadmium bioavailability: a meta-analysis - Yi Tan; Xue Zhou; Yutao Peng; Zijing Zheng; Xing Gao; Yan Ma; Shuo Chen; Shihao Cui; Beibei Fan; Qing Chen (Environmental Science and Pollution Research, 2022)

Astragalus Polysaccharides Reduce High-glucose-induced Rat Aortic Endothelial Cell Senescence and Inflammasome Activation by Modulating the Mitochondrial Na+/Ca2+ Exchanger - Xin-Yu Miao; Xiao-Xiao Zhu; Zhao-Yan Gu; Bo Fu; Shao-Yuan Cui; Yuan Zu; Ling-Jun Rong; Fan Hu; Xiang-Mei Chen; Yan-Ping Gong; Chun-Lin Li (Cell Biochemistry and Biophysics, 2022)

Itraconazole-Induced the Activation of Adenosine 5'-Monophosphate (Amp)-Activated Protein Kinase Inhibits Tumor Growth of Melanoma via Inhibiting ERK Signaling - Ni Fan; Yueping Sun; Lv Yan; Weining Chen; Yueping Wang; Shusheng Wang; Yu Song (Cell Biochemistry and Biophysics, 2022)

Large-scale model test for studying the water inrush during tunnel excavation in fault - Yingchao Wang; Fan Chen; Wanghua Sui; Fanshu Meng; Fan Geng (Bulletin of Engineering Geology and the Environment, 2022)

Controlling average number of photons received per biomass to promote the growth of Synechocystis sp. PPC 6803 - Jiangong Zhang; Fei Fan; Tao Yu; Jianpei Chen; Minxi Wan; Yuanguang Li (Biotechnology Letters, 2022)

Aberrant Gene Expression of Selenoproteins in Chicken Spleen Lymphocytes Induced by Mercuric Chloride - Jia-Hong Chu; Yu-Xue Yan; Xue-Wei Chen; Pei-Chao Gao; Lan-Xin Li; Rui-Feng Fan (Biological Trace Element Research, 2022)

Comprehensive analyses of initiation and failure mechanisms of the 2017 Xinmo catastrophic rockslide - Jia-wen Zhou; Gang Fan; Qin Chen; Xing-guo Yang (Journal of Mountain Science, 2022)

Variations in the effective and bankfull discharge for suspended sediment transport due to dam construction - Fan Chen; Li Chen; Wei Zhang; Jing Yuan; Kanghe Zhang (Frontiers of Earth Science, 2022)

Investigating the effect of compaction on the anaerobic digestion process of rice straw - Guang-Yin Chen; Hai-Nan Cao; Xue-Qian Fan; Yi-Chen Sun; Jing Wang; Jin-Zhu Dong; Pei Wu (BioEnergy Research, 2022)

Biological characterization and genomic analysis of Acinetobacter baumannii phage BUCT628 - Yinuo Zhu; Ke Han; Long Chen; Shizhong Luo; Huahao Fan; Yigang Tong (Archives of Virology, 2022)

Experimental Research on Overwater and Underwater Visual Image Stitching and Fusion Technology of Offshore Operation and Maintenance of Unmanned Ship - Yuanming Chen; Xiaobin Hong; Weiguo Chen; Huifang Wang; Tianhui Fan (Journal of Marine Science and Engineering, 2022)
The new way of offshore operation and maintenance based on unmanned ships has outstanding advantages. Aiming at the problem of lack of overall understanding of the complex environment above and under the water surface during the operation and maintenance of unmanned ships, a stitching and fusion technology of overwater and underwater visual images for unmanned ships is proposed. The software and hardware framework of the overwater and underwater visual image fusion system is constructed, the image processing methods in different environments are defined, and the accurate acquisition of obstacle information is realized. In the two experimental scenarios, the stitching accuracy of the obstacle model based on an extended neighborhood method can reach more than 85% within the obstacle distance of 8 m and more than 80% within the obstacle distance of 14 m. An image-driven Frustum–PointNets detection algorithm is proposed to obtain comprehensive obstacle avoidance information. In addition, the average accuracy of the three-dimensional detection of the algorithm is up to 91.40%. These results are significant and have a good reference value, as it demonstrates that the stitching and fusion method can effectively obtain the comprehensive information of overwater and underwater objects for unmanned ship.

Two new cytotoxic cycloartane triterpenoids from Aphanamixis polystachya (Wall.) R. N. Parker - Yi-ting Wang; Shi-rui Fan; Jie-yun Cai; Jing-jing Guo; Xin-fang Zhang; Bi-juan Yang; Xiao-jiang Hao; Duo-zhi Chen (Natural Product Research, 2022)

Anti-hyperglycaemic effect of labdane diterpenes isolated from the rhizome of Amomum maximum Roxb., an edible plant in Southwest China - Chuan-Li Lu; Li-Ning Wang; Ya-Jun Li; Qing-Fei Fan; Qing-Hua Huang; Jun-Jia Chen (Natural Product Research, 2022)

Natural Feed Supplements Improve Growth, Non-Specific Immune Responses and Resistance against Vibrio alginolyticus in Lates calcarifer - Zhen-Hao Liao; Huai-Ting Huang; Yu-Ru Lin; Bo-Ying Chen; Yi-Fan Lee; Yuan-Heng Lin; Chieh-Yuan Chuang; Fan-Hua Nan (Journal of Marine Science and Engineering, 2022)
This study aimed to investigate the effects of dietary natural feed supplement on the growth performance, non-specific responses, and disease resistance in Lates calcarifer. Three commercial products (A, B, and C) containing a basal probiotic mixture were tested. Product A contained a basal mixture of Paenibacillus sp., Bacillus subtilis, Bacillus amyloliquefaciens, and Lactobacillus rhamnosus (107 cfu/g for each probiotic); product B contained additional Lactobacillus plantarum (1010 cfu/g); and product C contained additional soybean peptides (500 g/kg) and garlic powder (1 g/kg). Each product was supplemented into subject diets at dosages of 1 or 2 g/kg (designated as the A1, A2, B1, B2, C1, and C2 groups, respectively). Following an eight-week trial, growth parameters (specific growth rate and feed conversion ratio), non-specific immune responses (O2− production, phagocytic rate, and phagocytic index), and the results of a challenge test against Vibrio alginolyticus were evaluated. The results show that all probiotic supplement groups exhibited an improvement in growth performance compared to the control group (non-probiotic diet). In terms of non-specific immunity parameters, a significant improvement in O2− production was found in the C2 group, whereas significant improvements in phagocytic activity were found in all the B and C groups. The C2 group displayed optimal O2− production, phagocytic rate, and phagocytic index results. For the challenge test, the C groups showed higher Vibrio resistance than the other experimental groups and the control group. These results suggest that product C, given at dosages of 2 g/kg, may serve as a growth-promoting and immunostimulatory additive for the cultivation of Asian seabass.

A new highly oxygenated germacranolide from Carpesium nepalense var. lanatum (C.B.Clarke) Kitam - Yi-Fan Yu; Yue-Qian Li; Ru-Yue Wang; Xu Liu; Wen-Bo Cui; Xiao-Han Chen; Cheng-Mu Zhao; Feng-Ming Qi; Zhan-Xin Zhang; Dong-Qing Fei (Natural Product Research, 2022)

Biocontrol potential of endophytic Trichoderma citrinoviride HT-1 against root rot of Rheum palmatum through both antagonistic effects and induced systemic resistance - DaWei Chen; QinZheng Hou; BaoLi Fan; Hui Zhang; LingYun Jia; Kun Sun (World Journal of Microbiology and Biotechnology, 2022)

Entrainment of Astrocytic and Neuronal Ca2+ Population Dynamics During Information Processing of Working Memory in Mice - Zhu Lin; Feng You; Ting Li; Yijia Feng; Xinyue Zhao; Jingjing Yang; Zhimo Yao; Ying Gao; Jiang-Fan Chen (Neuroscience Bulletin, 2022)

Selection of tolerant Eucalyptus genotypes to Botryosphaeriaceae species in southern China - GuoQing Li; WenPing Chen; Fan Jie; ShuaiFei Chen (Journal of Plant Pathology, 2022)

Marker-assisted introgression of Xa39 improve rice resistance to five Xanthomonas oryzae pv. oryzae strains - Yingyao Shi; Wei Zeng; Junping Xie; Fan Zhang; Dalong Zhuo; Lingling Gao; Mingfu Zhao; Xiaorong Shi; Minghui Xu; Zhenzhen Zheng; Zhiqi Hao; Hongyan Yuan; et al. (Journal of Plant Pathology, 2022)

Carnosine concentration and expression profiles of carnosine related genes in Mytilus after beta-alanine injection - Chen Pan; Zhi Liao; Jianyu He; Zhongqi Gu; Chunyue Wang; Meihua Fan; Isabella Buttino; Baoying Guo; Xiaojun Yan; Xiaolin Zhang (Journal of Oceanology and Limnology, 2022)

Alpine soil microbial community structure and diversity are largely influenced by moisture content in the Zoige wetland - S. Fan; J. Qin; H. Sun; Z. Jia; Y. Chen (International Journal of Environmental Science and Technology, 2022)

Rapid LC–MS/MS detection of different carbapenemase types in carbapenemase-producing Enterobacterales - Gen Li; Zhihan Ye; Wenyan Zhang; Nianzhen Chen; Yangqin Ye; Yuchao Wang; Fei Wu; Keli Wang; Lieying Fan (European Journal of Clinical Microbiology & Infectious Diseases, 2022)

Electromagnetic radiation prediction of damage characteristics of water-bearing sandstone under cyclic loading and unloading - Rongxi Shen; Hailiang Chen; Enlai Zhao; Taixun Li; Weijun Fan; Zichen Yuan (Bulletin of Engineering Geology and the Environment, 2022)

Evaluation and structural analysis of the functions of the Tibetan Plateau National Park Cluster - Dongjun Chen; Linsheng Zhong; Jie Fan; Hu Yu; Ding Yang; Yuxi Zeng (Journal of Geographical Sciences, 2022)

Identification of deep-buried potassium-rich brines in evaporate basin with aid of geophysical logging methods in co-exploration of oil and potash: a case study of Southwestern Sichuan Basin - Changbing Huang; Kegui Chen; Wei Hei; Linxiao Fan (Arabian Journal of Geosciences, 2022)

A new picrotoxane-type sesquiterpene from Dendrobium nobile Lindl - Pei Wang; Xin Chen; Cai-Hong Cai; Fan-Dong Kong; Sheng-Zhuo Huang; Jing-Zhe Yuan; Xing-Lian Xu; Wen-Li Mei; Hao-Fu Dai (Natural Product Research, 2022)

Isolation of a new monoterpenoid glycoside from Anhua dark tea based on an NMR-guided method and its cytotoxic activity against MDA-MB-231 and SH-SY5Y cell lines - Yunqiang Zhang; Jianyu Liu; Miao Chen; Yanhua Fan; Meichen Li; Andong Wang; Gaigai Liu; Yongnan Xu; Xuhong Ren; Yan Xiao (Natural Product Research, 2022)

Berberisides A-D: three novel prenylated benzoic acid derivatives and a clerodane glycoside from Berberis tsarica aherndt. - Zhao-Yue Dong; Qing-Hong Zeng; Lin Wei; Xin Guo; Yan Sun; Fan-Cheng Meng; Guo-Wei Wang; Xiao-Zhong Lan; Zhi-Hua Liao; Min Chen (Natural Product Research, 2022)

Earlier Activation of Interferon and Pro-Inflammatory Response Is Beneficial to Largemouth Bass (Micropterus salmoides) against Rhabdovirus Infection - Runzhen He; Qianrong Liang; Ningyu Zhu; Xiaoye Zheng; Xiaoming Chen; Fan Zhou; Xueyan Ding (Fishes, 2022)
In order to understand the immune response of largemouth bass against Micropterus salmoides Rhabdovirus (MSRV), assisting disease resistance breeding, three largemouth bass breeding varieties Micropterus salmoides “Youlu No 3” (U3), “Youlu No 1” (U1) and “Zhelu No 1” (P1) were challenged intraperitoneally with MSRV. Serum and tissues were sampled to study the changes in non-specific immune parameters, viral loads, and transcript levels of immune-related genes, and the cumulative mortality rate was recorded daily for 14 days. The results showed that the cumulative mortality rates in the U1, P1, and U3 groups were 6.66% ± 2.89%, 3.33% ± 2.89%, and 0, respectively. The higher mortality may attribute to the increased viral loads after infection in the liver (2.79 × 105 and 2.38 × 105 vs. 1.3 × 104 copies/mg), spleen (2.14 × 105 and 9.40 × 104 vs. 4.21 × 103 copies/mg), and kidney (3.59 × 104 and 8.40 × 103 vs. 2.42 × 103 copies/mg) in the U1 and P1 groups compared to the U3 group. The serum non-specific immune parameters (lysozyme, catalase, and acid phosphatase) were found to be increased significantly in the U3 group. In addition, the transcripts of interferon-related genes (IFN-γ, IRF3, and IRF7) and pro-inflammatory-related genes (TNF-α and IL-1β) exhibited up-regulation and peaked at 6 h post infection in the U3 group, which also exhibited up-regulation but peaked at 12–24 h post infection in the U1 and P1 groups. In conclusion, these findings indicate that earlier activation of interferon and pro-inflammatory response is beneficial to largemouth bass against MSRV infection. This experiment may provide an insight into understanding the immune mechanism of largemouth bass against MSRV infection and contributes to molecular-assisted selection.

Analytical and experimental analysis of the shear strength of bolted saw-tooth joints - Hang Lin; Penghui Sun; Yifan Chen; Youyan Zhu; Xiang Fan; Yanlin Zhao (European Journal of Environmental and Civil Engineering, 2022)

Identification and validation of quantitative trait loci for the functional stay green trait in common wheat (Triticum aestivum L.) via high-density SNP-based genotyping - Tianheng Ren; Tao Fan; Shulin Chen; Yongyan Chen; Xia Ou; Qing Jiang; Wanhua Peng; Zhenglong Ren; Feiquan Tan; Peigao Luo; Zhi Li (Theoretical and Applied Genetics, 2022)

Lineage tracing reveals the origin of Nestin-positive cells are heterogeneous and rarely from ependymal cells after spinal cord injury - Xiaoyu Xue; Muya Shu; Zhifeng Xiao; Yannan Zhao; Xing Li; Haipeng Zhang; Yongheng Fan; Xianming Wu; Bing Chen; Bai Xu; Yaming Yang; Weiyuan Liu; et al. (Science China Life Sciences, 2022)

Anterior Cingulate Cortex Mediates Hyperalgesia and Anxiety Induced by Chronic Pancreatitis in Rats - Dan Ren; Jia-Ni Li; Xin-Tong Qiu; Fa-Ping Wan; Zhen-Yu Wu; Bo-Yuan Fan; Ming-Ming Zhang; Tao Chen; Hui Li; Yang Bai; Yun-Qing Li (Neuroscience Bulletin, 2022)
Central sensitization is essential in maintaining chronic pain induced by chronic pancreatitis (CP), but cortical modulation of painful CP remains elusive. Here, we examined the role of the anterior cingulate cortex (ACC) in the pathogenesis of abdominal hyperalgesia in a rat model of CP induced by intraductal administration of trinitrobenzene sulfonic acid (TNBS). TNBS treatment resulted in long-term abdominal hyperalgesia and anxiety in rats. Morphological data indicated that painful CP induced a significant increase in FOS-expressing neurons in the nucleus tractus solitarii (NTS) and ACC, and some FOS-expressing neurons in the NTS projected to the ACC. In addition, a larger portion of ascending fibers from the NTS innervated pyramidal neurons, the neural subpopulation primarily expressing FOS under the condition of painful CP, rather than GABAergic neurons within the ACC. CP rats showed increased expression of vesicular glutamate transporter 1, and increased membrane trafficking and phosphorylation of the N -methyl-D-aspartate receptor (NMDAR) subunit NR2B and the α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor (AMPAR) subunit GluR1 within the ACC. Microinjection of NMDAR and AMPAR antagonists into the ACC to block excitatory synaptic transmission significantly attenuated abdominal hyperalgesia in CP rats, which was similar to the analgesic effect of endomorphins injected into the ACC. Specifically inhibiting the excitability of ACC pyramidal cells via chemogenetics reduced both hyperalgesia and comorbid anxiety, whereas activating these neurons via optogenetics failed to aggravate hyperalgesia and anxiety in CP rats. Taken together, these findings provide neurocircuit, biochemical, and behavioral evidence for involvement of the ACC in hyperalgesia and anxiety in CP rats, as well as novel insights into the cortical modulation of painful CP, and highlights the ACC as a potential target for neuromodulatory interventions in the treatment of painful CP.

The role of microRNA-155 in glomerular endothelial cell injury induced by high glucose - Kaiying He; Zhan Chen; Jing Zhao; Yang He; Rongrong Deng; Xin Fan; Jianqin Wang; Xiaochun Zhou (Molecular Biology Reports, 2022)
Objective To investigate the role of microRNA-155-5p on apoptosis and inflammatory response in human renal glomerular endothelial cells (HRGEC) cultured with high glucose. Methods The primary HRGEC were mainly studied, light microscopy was used to detect changes in cell morphology. Quantitative Real Time-Polymerase Chain Reaction, Western Blot, immunofluorescence were aimed to observe the mRNA and protein expression levels of target gene ETS-1, downstream factors VCAM-1, MCP-1 and cleaved caspase-3 in each group after high glucose treatment as well as transfection with miR-155 mimics or inhibitor. Results The expression of inflammatory factors and apoptosis of HRGEC cells increased under high glucose treatment. Compared with normal-glucose treatment, the expression of microRNA-155 markedly increased in HRGECs treated with high-glucose, as well as the mRNA and protein levels of ETS-1, VCAM-1, MCP-1 and cleaved caspase-3. Overexpression of microRNA-155 remarkably downregulated mRNA and protein levels of ETS-1, VCAM-1, MCP-1 and cleaved caspase-3, whereas miRNA-155 knockdown upregulated their levels. In addition, HRGEC cells were transfected with miR-155 mimics and ETS-1 siRNA with high glucose stimulation. The expression of ETS-1 was positively correlated with the expression of downstream factors VCAM-1 and MCP-1. These results suggest that ETS-1 can mediate endothelial cell inflammation by regulating VCAM-1 and MCP-1. Conclusion MiR-155 can negatively regulate the expression of target gene ETS-1 and its downstream factors VCAM-1, MCP-1 and cleaved caspase-3, thus mediating the inflammatory response and apoptosis of HRGEC.

Overexpression of a novel gene Aokap2 affects the growth and kojic acid production in Aspergillus oryzae - Yuzhen Li; Huanxin Zhang; Ziming Chen; Junxia Fan; Tianming Chen; Yi Xiao; Junyin Jie; Bin Zeng; Zhe Zhang (Molecular Biology Reports, 2022)

Design and synthesis of small molecular 2-aminobenzoxazoles as potential antifungal agents against phytopathogenic fungi - Lingling Fan; Zhongfu Luo; Changfei Yang; Bing Guo; Jing Miao; Yang Chen; Lei Tang; Yong Li (Molecular Diversity, 2022)

Correction to: Circular RNA hsa_circ_0000034 accelerates retinoblastoma advancement through the miR-361-3p/ADAM19 axis - Yanhua Jiang; Fan Xiao; Lin Wang; Ting Wang; Linlin Chen (Molecular and Cellular Biochemistry, 2022)

New Target of Oxidative Stress Regulation in Cochleae: Alternative Splicing of the p62/Sqstm1 Gene - Pengjun Li; Dan Bing; Xiaodi Wang; Jin Chen; Zhihui Du; Yanbo Sun; Fan Qi; Hanqi Chu (Journal of Molecular Neuroscience, 2022)

Cavin-1 promotes M2 macrophages/microglia polarization via SOCS3 - Wei Huang; Yiyi Hong; Wenjing He; Li Jiang; Wen Deng; Biyan Peng; Fen Tang; Chaolan Shen; Qianqian Lan; Hui Huang; Haibin Zhong; Jian Lv; et al. (Inflammation Research, 2022)

Physiological homeostasis alteration and cellular structure damage of Chlorella vulgaris exposed to silver nanoparticles with various microstructural morphologies - Ningcan Deng; Haibo Li; Yinghua Li; Fan Mo; Mingshuai Wang; Zhe Li; Xi Chen; Jianing Xu; Rui Chai; Hongxuan Wang (Environmental Science and Pollution Research, 2022)

Bioaccumulation and toxicity effects of flubendiamide in zebrafish (Danio rerio) - Zhiyuan Meng; Zhichao Wang; Xiaojun Chen; Yueyi Song; Miaomiao Teng; Tianle Fan; Yang Zheng; Jiajia Cui; Wangjin Xu (Environmental Science and Pollution Research, 2022)

Experimental study on the mechanical properties and energy evolution of hard rock during water immersion - Fan-Bo Wei; Bing-Rui Chen; Rui Wang; Guo-Liang Li; Tao Li; Xu Wang; Xin-Hao Zhu (Arabian Journal of Geosciences, 2022)

Investigation on grouting diffusion in inclined fracture with flowing water conditions - Jia-fan Zhang; Xun-xun Chen; Yang Liu; Hui-mei Zhang; Chun-lin Wang; Gang Fang (Arabian Journal of Geosciences, 2022)

Enhanced Intramuscular Bioavailability of Cannabidiol Using Nanocrystals: Formulation, In Vitro Appraisal, and Pharmacokinetics - Xinzhen Fu; Shiji Xu; Zhi Li; Kun Chen; Huaying Fan; Yu Wang; Zeping Xie; Lijuan Kou; Shumin Zhang (AAPS PharmSciTech, 2022)

Middle Triassic volcanic rocks from the Gangdese belt, southern Tibet: petrogenesis and implications for Tethys tectonic evolution - Jingui Wang; Fan Yang; M. Santosh; Xinquan Zhang; Wentong Wei; Shaopeng Zhuan; Juquan Zhang; Chao Chen; Shuo Wang; Xinpeng Yang; Fei Xue (International Geology Review, 2022)

Extensive sequence divergence between the reference genomes of Taraxacum kok-saghyz and Taraxacum mongolicum - Tao Lin; Xia Xu; Huilong Du; Xiuli Fan; Qingwen Chen; Chunyan Hai; Zijian Zhou; Xiao Su; Liquan Kou; Qiang Gao; Lingwei Deng; Jinsheng Jiang; et al. (Science China Life Sciences, 2022)

Polysaccharide Krestin Prevents Alzheimer’s Disease-type Pathology and Cognitive Deficits by Enhancing Monocyte Amyloid-β Processing - Si-Han Chen; Chen-Yang He; Ying-Ying Shen; Gui-Hua Zeng; Ding-Yuan Tian; Yuan Cheng; Man-Yu Xu; Dong-Yu Fan; Cheng-Rong Tan; An-Yu Shi; Xian-Le Bu; Yan-Jiang Wang (Neuroscience Bulletin, 2022)

Ameliorative effect of scutellarin on acute alcohol brain injury in mice - Tianmeng Zhang; Kun Wang; Hui Fan; Qiankun Yang; Xiao Zhang; Feixue Liu; Xin Feng; Yi Chen; Daoyang Teng; Panpan Zhao; Jingquan Dong (Journal of Zhejiang University-SCIENCE B, 2022)

Identification of Benign and Malignant Lung Nodules in CT Images Based on Ensemble Learning Method - Yifei Xu; Shijie Wang; Xiaoqian Sun; Yanjun Yang; Jiaxing Fan; Wenwen Jin; Yingyue Li; Fangchu Su; Weihua Zhang; Qingli Cui; Yanhui Hu; Sheng Wang; et al. (Interdisciplinary Sciences: Computational Life Sciences, 2022)

Bioinformatics approach to identify common gene signatures of patients with coronavirus 2019 and lung adenocarcinoma - Xiao Liang; Yali Chen; Yuchao Fan (Environmental Science and Pollution Research, 2022)

A bi-scale assessing framework for aesthetic ecosystem services of villages in a world heritage site - Yin-ping Ding; Zhi-lin Liu; Yuan-mei Jiao; Qiu-e Xu; Kan-feng Zhang; Cheng-jing Liu; Fan Chen (Journal of Mountain Science, 2022)

Development of 105 SNP markers in endangered turtle species Pelodiscus sinensis using RAD-seq - Qiming Xie; Fan Liu; Jilong Zhang; Xilei Li; Tiantian Chen; Guoxia Fang; Rensheng Ma; Shiping Su (Conservation Genetics Resources, 2022)

Simulated nitrogen deposition induces shifts in growth and resource-use strategies during range expansion of an invasive plant - Fang-Fang Huang; Guo-Hao Zhou; Hui-Xuan Liao; Zhe-Xuan Fan; Bao-Ming Chen (Biological Invasions, 2022)

Genomic characterization of a new enamovirus infecting common bean - Ruo-bin Lu; Ping-xiu Lan; Ru-jing Kang; Guan-lin Tan; Xiao-jiao Chen; Ruhui Li; Fan Li (Archives of Virology, 2022)

Correction to: Hepatitis C virus core protein activates Wnt/β-catenin signaling through multiple regulation of upstream molecules in the SMMC-7721 cell line - Jiao Liu; Zengchan Wang; Jia Tang; Renkuan Tang; Xiaoliang Shan; Wenlu Zhang; Qingmei Chen; Fan Zhou; Ke Chen; Ailong Huang; Ni Tang (Archives of Virology, 2022)

Another Record: Ocean Warming Continues through 2021 despite La Niña Conditions - Lijing Cheng; John Abraham; Kevin E. Trenberth; John Fasullo; Tim Boyer; Michael E. Mann; Jiang Zhu; Fan Wang; Ricardo Locarnini; Yuanlong Li; Bin Zhang; Zhetao Tan; et al. (Advances in Atmospheric Sciences, 2022)
The increased concentration of greenhouse gases in the atmosphere from human activities traps heat within the climate system and increases ocean heat content (OHC). Here, we provide the first analysis of recent OHC changes through 2021 from two international groups. The world ocean, in 2021, was the hottest ever recorded by humans, and the 2021 annual OHC value is even higher than last year’s record value by 14 ± 11 ZJ (1 zetta J = 10 21 J) using the IAP/CAS dataset and by 16 ± 10 ZJ using NCEI/NOAA dataset. The long-term ocean warming is larger in the Atlantic and Southern Oceans than in other regions and is mainly attributed, via climate model simulations, to an increase in anthropogenic greenhouse gas concentrations. The year-to-year variation of OHC is primarily tied to the El Niño-Southern Oscillation (ENSO). In the seven maritime domains of the Indian, Tropical Atlantic, North Atlantic, Northwest Pacific, North Pacific, Southern oceans, and the Mediterranean Sea, robust warming is observed but with distinct inter-annual to decadal variability. Four out of seven domains showed record-high heat content in 2021. The anomalous global and regional ocean warming established in this study should be incorporated into climate risk assessments, adaptation, and mitigation.

When tropical and subtropical congeners met: Multiple ancient hybridization events within Eriobotrya in the Yunnan‐Guizhou Plateau, a tropical‐subtropical transition area in China - Sufang Chen; Richard Milne; Renchao Zhou; Kaikai Meng; Qianyi Yin; Wei Guo; Yongpeng Ma; Kangshan Mao; Kewang Xu; Young‐Dong Kim; Truong Van Do; Wenbo Liao; et al. (Molecular Ecology, 2022)
Global climate changes during the Miocene may have created ample opportunities for hybridization between members of tropical and subtropical biomes at the boundary between these zones. Yet, very few studies have explored this possibility. The Yunnan‐Guizhou Plateau (YGP) in Southwest China is a biodiversity hotspot for vascular plants, located in a transitional area between the floristic regions of tropical Southeast Asia and subtropical East Asia. The genus Eriobotrya (Rosaceae) comprises both tropical and subtropical taxa, with 12 species recorded in the YGP, making it a suitable basis for testing the hypothesis of between‐biome hybridization. Therefore, we surveyed the evolutionary history of Eriobotrya by examining three chloroplast regions and five nuclear genes for 817 individuals (47 populations) of 23 Eriobotrya species (including 19 populations of 12 species in the YGP), plus genome re‐sequencing of 33 representative samples. We concluded that: (1) phylogenetic positions for 16 species exhibited strong cytonuclear conflicts, most probably due to ancient hybridization; (2) the YGP is a hotspot for hybridization, with 11 species showing clear evidence of chloroplast capture; and (3) Eriobotrya probably originated in tropical Asia during the Eocene. From the Miocene onwards, the intensification of the Eastern Asia monsoon and global cooling may have shifted the tropical‐subtropical boundary and caused secondary contact between species, thus providing ample opportunity for hybridization and diversification of Eriobotrya , especially in the YGP. Our study highlights the significant role that paleoclimate changes probably played in driving hybridization and generating rich species diversity in climate transition zones.

RETRACTED ARTICLE: Exosomes derived from bone mesenchymal stem cells attenuate myocardial fibrosis both in vivo and in vitro via autophagy activation: the key role of miR-199a-3p/mTOR pathway - Chenrong Fan; Qizeng Wang; Youjin Chen; Tingting Ye; Yuncao Fan (Human Cell, 2022)

Antibiotic-induced gut dysbiosis and barrier disruption and the potential protective strategies - Hui Duan; Leilei Yu; Fengwei Tian; Qixiao Zhai; Liuping Fan; Wei Chen (Critical Reviews in Food Science and Nutrition, 2022)

A First Insight Into the Heat-Induced Changes in Proteomic Profiles of the Coral Symbiotic Bacterium Endozoicomonas montiporae - Ya-Fan Chan; Chia-Yu Chen; Chih-Ying Lu; Yung-Chi Tu; Kshitij Tandon; Shinya Shikina; Sen-Lin Tang (Frontiers in Marine Science, 2022)
Endozoicomonas , a core bacterial group in corals, may also be a coral symbiont. Endozoicomonas communities often decrease rapidly in corals under heat stress. However, how the bacteria respond to changes in temperature and coral host during heat stress is unknown. Here, we employed the cultivable, dominant species E. montiporae as a working organism to explore how Endozoicomonas responds to heat stress. We designed two experiments to clarify the extent to which E. montiporae is influenced by temperature and coral host. We detected differentially expressed protein (DEP) profiles in this bacterium at 31 and 33°C compared to 25°C by tandem mass tags-based quantitative proteome analysis. Fifty DEPs, including many heat shock proteins, were detected when the temperature changed. The expression of antioxidant defense proteins and key pyruvate synthase proteins decreased, suggesting that E. montiporae were in a physiology of stress at 33°C. Furthermore, some proteins were differentially expressed because of the heat-stress-treated coral lysate specifically, suggesting that not only heat but also heat-induced host factors can affect the protein expression of the bacterium. This study provides an in-depth analysis of how the molecular mechanisms of Endozoicomonas are affected by heat stress and coral host.

A Novel Stilbene Analogue: Antioxidant Activity and Application in Controlling the Quality and Bacterial Growth of Shrimp Refrigerated at 4ºC - Wei Xia; Vara Prasad Chakka; Kai Chen; Fan Wang; Yuan-Yuan Xie; Robert C. Hider; Tao Zhou (Journal of Aquatic Food Product Technology, 2022)

Classifications and Characteristics of Marine Heatwaves in the Northern South China Sea - Yinxia Wang; Jisheng Zeng; Zheng Wei; Shan Li; Song Tian; Fan Yang; Qidong Chen; Yinghui He (Frontiers in Marine Science, 2022)
The classifications and associated characteristics of marine heatwaves (MHWs) in the northern South China Sea (SCS) have been investigated. Based on the ratio of the area with MHWs to the total area of the northern SCS, the MHWs are divided into three categories, i.e., narrow coverage, moderate coverage, and wide coverage. Different kinds of MHWs (i.e., narrow coverage, moderate coverage, and wide coverage) contribute around 64, 28, and 8% to the total days with MHWs, respectively. Narrow coverage MHW scatters over the northern SCS continental shelf, and moderate (wide) coverage MHWs are concentrated east of Hainan Island (mid of northern SCS continental shelf). Wide coverage MHWs contribute more than 50% to the total MHW cumulative sea surface temperature (SST) anomalies. The cumulative days and temperature anomalies of all kinds of MHWs exhibit significant long-term trends and decadal variability.

Directionally separable dilated CNN with hierarchical attention feature fusion for hyperspectral image classification - Chenming Li; Tingting Fan; Zhonghao Chen; Hongmin Gao (International Journal of Remote Sensing, 2022)

Identification and analysis of oil candidate genes reveals the molecular basis of cottonseed oil accumulation in Gossypium hirsutum L. - Zhibin Zhang; Juwu Gong; Zhen Zhang; Wankui Gong; Junwen Li; Yuzhen Shi; Aiying Liu; Qun Ge; Jingtao Pan; Senmiao Fan; Xiaoying Deng; Shaoqi Li; et al. (Theoretical and Applied Genetics, 2022)

Single-cell RNA sequencing reveals Nestin+ active neural stem cells outside the central canal after spinal cord injury - Muya Shu; Xiaoyu Xue; Hu Nie; Xianming Wu; Minghan Sun; Lianyong Qiao; Xing Li; Bai Xu; Zhifeng Xiao; Yannan Zhao; Yongheng Fan; Bing Chen; et al. (Science China Life Sciences, 2022)

Necrostatin-1 Relieves Learning and Memory Deficits in a Zebrafish Model of Alzheimer’s Disease Induced by Aluminum - Xiaocheng Gao; Ping Zhang; Jianping Chen; Lan Zhang; Nan Shang; Jin Chen; Rong Fan; Yanhong Wang; Tao Huang; Qiao Niu; Qinli Zhang (Neurotoxicity Research, 2022)

Loss of O-GlcNAcylation on MeCP2 at Threonine 203 Leads to Neurodevelopmental Disorders - Juanxian Cheng; Zhe Zhao; Liping Chen; Ying Li; Ruijing Du; Yan Wu; Qian Zhu; Ming Fan; Xiaotao Duan; Haitao Wu (Neuroscience Bulletin, 2022)

Design, synthesis and fungicidal activity of pyrazole–thiazole carboxamide derivatives - Zesheng Hao; Bin Yu; Wei Gao; Haoyin Chen; Dongyan Yang; You Lv; Yue Zhang; Lei Chen; Zhijin Fan (Molecular Diversity, 2022)

Effects of protein oxidation, cathepsins, and various freezing temperatures on the quality of superchilled sturgeon fillets - Nana Zhao; Xianqing Yang; Yujin Li; Haohao Wu; Yiping Chen; Ruichang Gao; Feng Xiao; Fan Bai; Jinlin Wang; Zunying Liu; Xin Gao; Yuanhui Zhao (Marine Life Science & Technology, 2022)

Poor speech recognition, sound localization and reorganization of brain activity in children with unilateral microtia-atresia - Qiang Liu; Yibei Wang; Tengyu Yang; Yue Fan; Bo Hou; Yushan Chen; Jian Wang; Xiaowei Chen (Brain Imaging and Behavior, 2022)
Microtia-atresia is a congenital malformation of the external ear, often affecting one side and being associated with severe-to-profound unilateral conductive hearing loss (UCHL). Although the impact of unilateral hearing loss (UHL) on speech recognition, sound localization and brain plasticity has been intensively investigated, less is known about the subjects with unilateral microtia-atresia (UMA). Considering these UMA subjects have hearing loss from birth, we hypothesize it has a great effect on brain organization. A questionnaire on speech recognition and spatial listening ability was administered to 40 subjects with UMA and 40 age- and sex-matched controls. UMA subjects showed poorer speech recognition in laboratory and poorer spatial listening ability. However, cognitive scores determined by the Montreal Cognitive Assessment (MoCA) and Wechsler Intelligence Scale for Children (WISC-IV) did not differ significantly in these two groups. The impact of hearing loss in UMA on brain functional organization was examined by comparing resting-state fMRIs (rs-fMRI) in 27 subjects with right-sided UMA and 27 matched controls. UMA subjects had increased nodal betweenness in visual networks and DMN but decreases in auditory and attention networks. These results indicate that UCHL in UMA causes significant abnormalities in brain organization. The impact of UCHL on cognition should be further examined with a battery of tests that are more challenging and better focused on the cognitive networks identified.

Improved Agrobacterium tumefaciens-mediated transformation using antibiotics and acetosyringone selection in cucumber - Changxia Du; Li’ang Chai; Chen Liu; Yuyang Si; Huaifu Fan (Plant Biotechnology Reports, 2022)

Transcriptome Analysis Reveals Molecular Mechanisms Underlying Methyl Jasmonate-mediated Biosynthesis of Protopanaxadiol-type Saponins in Panax notoginseng Leaves - Ying Li; Yuan Lin; Bing Jia; Geng Chen; Huineng Shi; Rui Xu; Xuejiao Li; Junrong Tang; Qingyan Tang; Guanghui Zhang; Jianli Yang; Wei Fan; et al. (Journal of Plant Biology, 2022)

Analysis of the long noncoding RNA profiles of RD and SH-SY5Y cells infected with coxsackievirus B5, using RNA sequencing - Peiying Teng; Heng Yang; Jing Li; Fan Yang; Wei Chen (Archives of Virology, 2022)

Chronic bisphenol A exposure triggers visual perception dysfunction through impoverished neuronal coding ability in the primary visual cortex - Fan Hu; Guangwei Xu; Linke Zhang; Huan Wang; Jiachen Liu; Zhi Chen; Yifeng Zhou (Archives of Toxicology, 2022)

The impact of different rotation regime on the soil bacterial and fungal communities in an intensively managed agricultural region - Jie Lu; Wenxin Li; Yuhao Yang; Fan Ye; Huayu Lu; Xiangyang Chen; Fu Chen; Xinya Wen (Archives of Microbiology, 2022)

Extracellular matrix stiffness controls VEGF165 secretion and neuroblastoma angiogenesis via the YAP/RUNX2/SRSF1 axis - Min Bao; Yi Chen; Ji-Ting Liu; Han Bao; Wen-Bin Wang; Ying-Xin Qi; Fan Lv (Angiogenesis, 2022)

Modelling deep convective activity using lightning clusters and machine learning - Manxing Shi; Wei Zhang; Peng Fan; Qihao Chen; Zhipeng Liu; Qin Li; Xiuguo Liu (International Journal of Climatology, 2022)
Retrieving thunderstorm activity through specific thermodynamic and kinematic parameters is paramount for predicting deep convective weather and investigating long‐term climatology of storm. However, the reliability of the relationship between parameters and convective events is restricted by the modelling methods and sampling of thunderstorm activity. There is no objective definition of a thunderstorm, so the clustering method is applied to the cloud‐to‐ground (CG) lightning stroke data in Central China to identify lightning clusters. These clusters are then gridded and associated with environmental variables derived from ERA5 reanalysis. Finally, machine learning (ML) technologies are applied to model the occurrence of thunderstorms. In addition, ERA5 is also evaluated. The parameters related to moisture and lapse rate calculated by ERA5 are close to sounding measurements, such as Td850, PW, LR700_400 and KI, whose correlation coefficients exceed 0.90. ERA5 has a good estimation of some parameters that are susceptible to the influence of the boundary layer. Compared with the lightning strike‐based scheme, our scheme obtains the best performance index values. An agreement between observations and predictions based on lightning clusters is also evident from the diurnal cycle of thunderstorm probabilities. Although thunderstorm activity on complex terrain is underestimated, the created ML model can explain 61.4% of the variance in the observed frequency. The results of the significance test reveal that there are statistically significant differences between the soundings corresponding to some isolated CG strikes and the thunderstorm class, but the distribution is the same as that of the non‐thunderstorm class. Solar radiation, topographic features and lake distribution play a major role in promoting the occurrence and development of thunderstorms.

Tropical tall forests are more sensitive and vulnerable to drought than short forests - Liyang Liu; Xiuzhi Chen; Philippe Ciais; Wenping Yuan; Fabienne Maignan; Jin Wu; Shilong Piao; Ying‐Ping Wang; Jean‐Pierre Wigneron; Lei Fan; Pierre Gentine; Xueqin Yang; et al. (Global Change Biology, 2022)
Our limited understanding of the impacts of drought on tropical forests significantly impedes our ability in accurately predicting the impacts of climate change on this biome. Here, we investigated the impact of drought on the dynamics of forest canopies with different heights using time‐series records of remotely sensed Ku‐band vegetation optical depth (Ku‐VOD), a proxy of top‐canopy foliar mass and water content, and separated the signal of Ku‐VOD changes into drought‐induced reductions and subsequent non‐drought gains. Both drought‐induced reductions and non‐drought increases in Ku‐VOD varied significantly with canopy height. Taller tropical forests experienced greater relative Ku‐VOD reductions during drought and larger non‐drought increases than shorter forests, but the net effect of drought was more negative in the taller forests. Meta‐analysis of in situ hydraulic traits supports the hypothesis that taller tropical forests are more vulnerable to drought stress due to smaller xylem‐transport safety margins. Additionally, Ku‐VOD of taller forests showed larger reductions due to increased atmospheric dryness, as assessed by vapor pressure deficit, and showed larger gains in response to enhanced water supply than shorter forests. Including the height‐dependent variation of hydraulic transport in ecosystem models will improve the simulated response of tropical forests to drought.

Combined Use of eDNA Metabarcoding and Bottom Trawling for the Assessment of Fish Biodiversity in the Zhoushan Sea - Shan Zhou; Chenrong Fan; Haoming Xia; Jian Zhang; Wei Yang; Dengjie Ji; Lei Wang; Li Chen; Nannan Liu (Frontiers in Marine Science, 2022)
With the increase in fishing intensity and the intensification of marine pollution, the fishery resources in the Zhoushan Sea are seriously degraded, and the difficulty of censusing fish diversity hampers effective management in marine fishes. Environmental DNA metabarcoding and bottom trawl methods were used to determine the ability of the methods to distinguish fish assemblages in the Zhoushan Sea. The species composition and diversity of the Zhoushan Sea were assessed via high-throughput sequencing analysis of eDNA coupled with bottom trawl fishery survey data, after which the two methods were compared. eDNA screening identified 38.2% more fish species than bottom trawls. Combining these two methods, 33 orders, 65 families, and 130 species of fishes were identified. Perciformes and Clupeiformes, the most abundant orders in the catch, represented 31.5 and 10.0% of the total fish abundance, respectively. The results of ANOSIM and redundancy analyses indicated that the fish community structure varied significantly between summer and winter, however depth and temperature being the main environmental factors influencing fish distribution. The biodiversity index was higher in summer than in winter. Thus, our work provides more detailed seasonal data on biodiversity in the Zhoushan Sea, which is essential for the long-term management and conservation of coastal biodiversity. Compared with traditional survey methods, eDNA determination is highly sensitive, accurate, cost-efficient, and suitable for fish diversity studies in relevant sea areas. Although this approach cannot completely replace traditional methods, our findings demonstrate that it provides a reliable complementary method for assessing fish diversity in marine ecosystems.

New paraconic acids from the endophytic fungus Xylariaceae sp. J4 - Chao Yuan; Xue-Chun Shu; Lin Fan; Ying-Bo Zhang; Ling-Liang Guan; Fu-Lai Yu; Xiao-Lu Chen; Gang Li (Natural Product Research, 2022)

Cloning and expression analysis of juvenile hormone epoxide hydrolase-like ( EsJHEH-like ) from Eriocheir sinensis , and its potential roles in methyl farnesoate metabolism - Tiantian Chen; Yingzhu Diao; Ruihan Xu; Na Sheng; Fan Liu; Qiming Xie; Shiping Su; Keyi Ma; Xilei Li (Invertebrate Reproduction & Development, 2022)

SYL3-k increases style length and yield of F1 seeds via enhancement of endogenous GA4 content in Oryza sativa L. pistils - Xiaojing Dang; Yuanqing Zhang; Yulong Li; Siqi Chen; Erbao Liu; Bingjie Fang; Qiangming Liu; Dong She; Zhiyao Dong; Zhilan Fan; Dalu Li; Hui Wang; et al. (Theoretical and Applied Genetics, 2022)
Key message SYL3-k allele increases the outcrossing rate of male sterile line and the yield of hybrid F 1 seeds via enhancement of endogenous GA 4 content in Oryza sativa L. pistils. The change in style length might be an adaptation of rice cultivation from south to north in the northern hemisphere. Abstract The style length (SYL) in rice is one of the major factors influencing the stigma exertion, which affects the outcross rate of male sterile line and the yield of hybrid F 1 seeds. However, the biological mechanisms underlying SYL elongation remain elusive. Here, we report a map-based cloning and characterisation of the allele qSYL3-k . The qSYL3-k allele encodes a MADS-box family transcription factor, and it is expressed in various rice organs. The qSYL3-k allele increases SYL via the elongation of cell length in the style, which is associated with a higher GA 4 content in the pistil. The expression level of OsGA3ox2 in pistils with qSYL3-k alleles is significantly higher than that in pistils with qSYL3-n allele on the same genome background of Nipponbare. The yield of F 1 seeds harvested from plants with 7001S SYL3−k alleles was 16% higher than that from plants with 7001S SYL3−n allele. The sequence data at the qSYL3 locus in 136 accessions showed that alleles containing the haplotypes qSYL3 AA , qSYL3 AG , and qSYL3 GA increased SYL, whereas those containing the haplotype qSYL3 GG decreased it. The frequency of the haplotype qSYL3 GG increases gradually from the south to north in the northern hemisphere. These findings will facilitate improvement in SYL and yield of F 1 seeds henceforward.

Identification of A-to-I RNA editing profiles and their clinical relevance in lung adenocarcinoma - Cheng Wang; Mingtao Huang; Congcong Chen; Yuancheng Li; Na Qin; Zijian Ma; Jingyi Fan; Linnan Gong; Hui Zeng; Liu Yang; Xianfeng Xu; Jun Zhou; et al. (Science China Life Sciences, 2022)

Magnetoresponsive nanozyme: magnetic stimulation on the nanozyme activity of iron oxide nanoparticles - Yuan He; Xiaoyong Chen; Ye Zhang; Yanyun Wang; Mengyao Cui; Galong Li; Xiaoli Liu; Haiming Fan (Science China Life Sciences, 2022)

Phylogeny and conservation of plant U2A/U2A’, a core splicing component in U2 spliceosomal complex - Yue Liu; Yuan Tian; Lan-Xiang Wang; Tao Fan; Jianhua Zhang; Mo-Xian Chen; Ying-Gao Liu (Planta, 2022)

Taxonomical and functional bacterial community selection in the rhizosphere of the rice genotypes with different nitrogen use efficiencies - Wei Chen; Yan Gao; Jie Yang; Fangjun Fan; Weiguo Zhang; Jiangye Li; Cong Zhou; Gaoling Shi; Fei Tong; Guangping Fan (Plant and Soil, 2022)

Phosphoproteomics of cold stress-responsive mechanisms in Rhododendron chrysanthum - Yunbo Liu; Hang Fan; Jiawei Dong; Jianyu Chen; Hongwei Xu; Xiaofu Zhou (Molecular Biology Reports, 2022)

An innovative targeted therapy for fluoroscopy-induced chronic radiation dermatitis - Kai-Che Wei; Shih-Fan Lai; Wei-Lun Huang; Kuo-Chung Yang; Ping-Chin Lai; Wan-Ju Wei; Tsung-Hsien Chang; Yun-Chen Huang; Ya-Chuan Tsai; Shin-Chih Lin; Sun-Jang Lin; Shih-Chieh Lin (Journal of Molecular Medicine, 2022)
Fluoroscopy-induced chronic radiation dermatitis (FICRD) is a complication of fluoroscopy-guided intervention. Unlike acute radiation dermatitis, FICRD is different as delayed onset and usually appears without preexisting acute dermatitis. Unfortunately, the chronic and progressive pathology of FICRD makes it difficult to treat, and some patients need to receive wide excision and reconstruction surgery. Due to lack of standard treatment, investigating underlying mechanism is needed in order to develop an effective therapy. Herein, the Hippo pathway is specifically identified using an RNA-seq analysis in mild damaged skin specimens of patients with FICRD. Furthermore, specific increase of the Yes-associated protein (YAP1), an effector of the Hippo pathway, in skin region with mild damage plays a protective role for keratinocytes via positively regulating the numerous downstream genes involved in different biological processes. Interestingly, irradiated-keratinocytes inhibit activation of fibroblasts under TGF-β1 treatment via remote control by an exosome containing YAP1. More importantly, targeting one of YAP1 downstream genes, nuclear receptor subfamily 3 group C member 1 (NR3C1), which encodes glucocorticoid receptor, has revealed its therapeutic potential to treat FICRD by inhibiting fibroblasts activation in vitro and preventing formation of radiation ulcers in a mouse model and in patients with FICRD. Taken together, this translational research demonstrates the critical role of YAP1 in FICRD and identification of a feasible, effective therapy for patients with FICRD. Key messages • YAP1 overexpression in skin specimens of radiation dermatitis from FICRD patient. • Radiation-induced YAP1 expression plays protective roles by promoting DNA damage repair and inhibiting fibrosis via remote control of exosomal YAP1. • YAP1 positively regulates NR3C1 which encodes glucocorticoid receptor expression. • Targeting glucocorticoid receptor by prednisolone has therapeutic potential for FICRD patient.

Associations between lung-deposited dose of particulate matter and culture-positive pulmonary tuberculosis pleurisy - Kuan-Jen Bai; Nguyen Thanh Tung; Ta-Chih Hsiao; Tsai-Ling Chen; Kian Fan Chung; Shu-Chuan Ho; Cheng-Yu Tsai; Jen-Kun Chen; Chun-Nin Lee; Kang-Yun Lee; Chih-Cheng Chang; Tzu-Tao Chen; et al. (Environmental Science and Pollution Research, 2022)

Nanoscale zero-valent iron particles supported on sludge-based biochar for the removal of chromium (VI) from aqueous system - Xi Chen; Guangjian Fan; Haibo Li; Yinghua Li; Ran Zhang; Yu Huang; Xinyang Xu (Environmental Science and Pollution Research, 2022)

An emerging chemical fumigant: two-sided effects of dazomet on soil microbial environment and plant response - Ran Chen; Weitao Jiang; Shaozhuo Xu; Hai Fan; Xuesen Chen; Xiang Shen; Chengmiao Yin; Zhiquan Mao (Environmental Science and Pollution Research, 2022)

Triaxial test on the response of mechanical property of frozen body in unconsolidated aquifer to mining-induced stress - Gangwei Fan; Tao Luo; Sixiang Liu; Dongsheng Zhang; Bang Liu; Mingwei Chen (Bulletin of Engineering Geology and the Environment, 2022)

Implications of spatial priority areas for hydrological ecosystem services through coupling hydrology model and Zonation model under different economic costs of water utilizations in northernmost of Japan - Min Fan; Manjiang Shi; Yunfeng Liu; Wen Chen; Yue Deng; Meiling Wang (Mitigation and Adaptation Strategies for Global Change, 2022)

Identification and characterization of a novel gene Aokap1 involved in growth and kojic acid synthesis in Aspergillus oryzae - Yuzhen Li; Huanxin Zhang; Ziming Chen; Junxia Fan; Tianming Chen; Bin Zeng; Zhe Zhang (Archives of Microbiology, 2022)

Nakamurella leprariae sp. nov., isolated from a lichen sample - De-Feng An; Shao-Juan Yang; Long-Qian Jiang; Xin-Yu Wang; Xiao-Yu Huang; Lei Lang; Xue-Mei Chen; Ming-Qun Fan; Gui-Ding Li; Ming-Guo Jiang; Li-Song Wang; Cheng-Lin Jiang; et al. (Archives of Microbiology, 2022)

Effects of different compaction methods on the performance of reinforced earth retaining wall - Lihua Li; Chengbin Fan; Han Yan; Hang Li; Xinlong Zhou; Na Chen; Jie Huang; Zhi Chen (Arabian Journal of Geosciences, 2022)

Optimization and Application of an Efficient and Stable Inhalation Exposure System for Rodents - Zi Fan; Bo Zhou; Yujia Liu; Wu Sun; Yuntao Fang; Hongguo Lu; Dongya Chen; Kuikui Lu; Xinyue Wu; Tian Xiao; Wenjing Xie; Qian Bian (AAPS PharmSciTech, 2022)

Ferroptosis inhibitory constituents from the fruits of Cullen corylifolium - Aftab Yaseen; Fan Yang; Xia Zhang; Fu Li; Bin Chen; Ahmed Hassan Ibrahim Faraag; Ming-Kui Wang; Xiao-Fei Shen; Lun Wang (Natural Product Research, 2021)

Risk assessment of multiple-mycotoxin exposure for consumers of chestnuts in Shandong Province markets in China - Jingyun Liang; Mingxiao Ning; Shuai Guan; Liping Fang; Xiao Chen; Zhan Dong; Lixia Fan (Food Additives & Contaminants: Part A, 2021)

Is Cerebral Amyloid-β Deposition Related to Post-stroke Cognitive Impairment? - Fubing Ouyang; Zimu Jiang; Xinran Chen; Yicong Chen; Jiating Wei; Shihui Xing; Jian Zhang; Yuhua Fan; Jinsheng Zeng (Translational Stroke Research, 2021)

Thermal–Mechanical Modeling of a Rock/Proppant System to Investigate the Role of Shale Creep on Proppant Embedment and Fracture Conductivity - Ming Fan; Yanhui Han; Cheng Chen (Rock Mechanics and Rock Engineering, 2021)

A Coal Burst Risk Assessment Model of Seismic Events Based on Multiple Seismic Source Parameters: A Case Study of the Huating Coal Mine, Gansu Province, China - Fan Chen; Anye Cao; Zhengzhao Liang; Yaoqi Liu (Natural Resources Research, 2021)

Synthesis and evaluation of mycophenolic acid derivatives as potential anti-Toxoplasma gondii agents - Fan-Fan Shang; Mei-Yuan Wang; Jiang-Ping Ai; Qing-Kun Shen; Hong-Yan Guo; Chun-Mei Jin; Fen-Er Chen; Zhe-Shan Quan; Lili Jin; Changhao Zhang (Medicinal Chemistry Research, 2021)

A Comparative Study on the Characteristics of the Urbanization Processes Between China and India from 1992 to 2013 Using DMSP-OLS NTL Images - Guangwei Sun; Mengzhen Zhang; Junfu Fan; Qi Jiang; Jiahao Chen; Panpan Zhang (Journal of the Indian Society of Remote Sensing, 2021)

A Multi-perspective Narrative-Based Geovisualization Dashboard for the 2020 US Presidential Election - Jinmeng Rao; Kexin Chen; Ellie Fan Yang; Jacob Kruse; Kyler Hudson; Song Gao (Journal of Geovisualization and Spatial Analysis, 2021)

Development of a loop-mediated isothermal amplification assay for the rapid detection of six common respiratory viruses - Nianzhen Chen; Yuying Si; Gen Li; Ming Zong; Wenyan Zhang; Yangqin Ye; Lieying Fan (European Journal of Clinical Microbiology & Infectious Diseases, 2021)

Antibiotic accumulation, growth performance, intestinal diversification, and function of Nile tilapia (Oreochromis niloticus) feed by diets supplemented with different doses of sulfamethoxazole - Longxiang Fang; Xi Chen; Xiangbao Shan; Liping Qiu; Limin Fan; Shunlong Meng; Chao Song (Environmental Science and Pollution Research, 2021)

The health risk assessment of Heavy Metals (HMs) in road dust based on Monte Carlo simulation and bio-toxicity: a case study in Zhengzhou, China - Huina Zhu; Xiaolong Liu; Chunhong Xu; Liangbo Zhang; Hanyu Chen; Fan Shi; Ying Li; Yongzhi Liu; Baozhong Zhang (Environmental Geochemistry and Health, 2021)

A diagnostic model for the large-scale tropical circulation based on moist static energy balance - Chen-Shuo Fan; Dietmar Dommenget (Climate Dynamics, 2021)

Dietary Copper Supplementation Increases Growth Performance by Increasing Feed Intake, Digestibility, and Antioxidant Activity in Rex Rabbits - Fan Li; Lei Liu; Xiaoyang Chen; Bin Zhang; Fuchang Li (Biological Trace Element Research, 2021)

Effect of lgals3a on embryo development of zebrafish - Kan Chen; Yuqi Fan; Jun Gu; Zhihua Han; Yue Wang; Lin Gao; Huasu Zeng; Chengyu Mao; Changqian Wang (Transgenic Research, 2021)

Expression of Circulating Rennin—Angiotensin—Aldosterone-Related microRNAs in Patients with Thyrotoxic Heart Disease - H. M. Li; Y. X. Chen; X. M. Fan; L. L. Chen (Bulletin of Experimental Biology and Medicine, 2021)

Bacterial community changes and their responses to nitrogen addition among different alpine grassland types at the eastern edge of Qinghai–Tibetan Plateau - Xing-e Qi; Chen Wang; Tianjiao He; Fan Ding; Xinfang Zhang; Lizhe An; Shijian Xu (Archives of Microbiology, 2021)

Study on shear strength and structure of Malan loess under wetting–drying cycles - Yuyang Qin; Guoying Li; Xinjian Chen; Kaifang Fan (Arabian Journal of Geosciences, 2021)

Research on application of ground penetrating radar array method based on plane beam signal in different geological models - Fan Cui; Yi Chen; Yongqi Zhang; Yunfei Du (Acta Geophysica, 2021)

Environmental contamination with SARS‐CoV ‐2 in COVID ‐19 hospitals in Wuhan, China, 2020 - Wei Liu; Dingchen Li; Chaojie Yang; Fangyan Chen; Ruizhong Jia; Leili Jia; Xinyi Xia; Shanhong Fan; Qing Tan; Yuehua Ke; Yong Chen; Haifeng Li; et al. (Environmental Microbiology, 2021)
Summary Coronavirus disease 2019 (COVID‐19) pandemic has caused high number of infections and deaths of healthcare workers globally. Distribution and possible transmission route of SARS‐CoV‐2 in hospital environment should be clarified. We herein collected 431 environmental (391 surface and 40 air) samples in the intensive care unit (ICU) and general wards (GWs) of three hospitals in Wuhan, China from February 21 to March 4, 2020, and detected SARS‐CoV‐2 RNA by real‐time quantitative PCR. The viral positive rate in the contaminated areas was 17.8% (28/157), whereas there was no virus detected in the clean areas. Higher positive rate (22/59, 37.3%) was found in ICU than that in GWs (3/63, 4.8%). The surfaces of computer keyboards and mouse in the ICU were the most contaminated (8/10, 80.0%), followed by the ground (6/9, 66.7%) and outer glove (2/5, 40.0%). From 17 air samples in the contaminated areas, only one sample collected at a distance of around 30 cm from the patient was positive. Enhanced surface disinfection and hand hygiene effectively decontaminated the virus from the environment. This finding might help understand the transmission route and contamination risk of SARS‐CoV‐2 and evaluate the effectiveness of infection prevention and control measures in healthcare facilities.

Spatial correlations of daily precipitation over mainland China - Conghui Fan; Shuiqing Yin; Deliang Chen (International Journal of Climatology, 2021)
Knowledge of spatial correlations of precipitation is important for the generation of grid‐based surface precipitation data sets, deployment of data collection, selection of downscaling strategies, and interpretation of paleoclimate reconstructions. Spatial correlations of daily precipitation in China were analyzed based on a daily precipitation data set from 1951 through 2014 for 2,208 stations by dividing them into 13 regions. Interstation Pearson correlation coefficient r for the daily precipitation series and the corresponding interstation distance d were calculated for each region. The exponential spatial correlation model () was fitted by the r‐d pairs, in which c 0 , d 0 and s 0 were the parameter variance, scale and shape, respectively. The results showed that: (a) The determination coefficient R 2 of the correlation model varied from 0.54 to 0.96, with a mean of 0.82 and the regional maximum correlation distance d 0 varied from 102.2 to 201.7 km, with a mean of 155.2 km. Western regions generally had smaller d 0 than eastern regions, which indicates rain events in the western regions were more local; (b) The goodness‐of‐fit of the model was improved by dividing samples into West‐East (W‐E) and North‐South (N‐S) directions. The average of d 0 for all regions (190.2 km) for the W‐E direction is larger than that for the N‐S direction (142.9 km); (c) The correlation distances in summer and dry years are shorter than those in winter and wet years. However, the difference of correlation distance between dry and wet years was subtle compared with those between summer and winter, and between W‐E and N‐S directions. Seven regions were divided based on the spatial correlations of daily precipitation and different spatial models were suggested to be used for different regions, seasons and directions when the interpolation of daily precipitation is conducted for the generation of gridded surface precipitation data sets.

A Unique Diel Pattern in Carbonate Chemistry in the Seagrass Meadows of Dongsha Island: The Enhancement of Metabolic Carbonate Dissolution in a Semienclosed Lagoon - Wen-Chen Chou; Lan-Feng Fan; Chang-Chang Yang; Ying-Hsuan Chen; Chin-Chang Hung; Wei-Jen Huang; Yung-Yen Shih; Keryea Soong; Hsiao-Chun Tseng; Gwo-Ching Gong; Hung-Yu Chen; Cheng-Kuan Su (Frontiers in Marine Science, 2021)
In contrast to other seagrass meadows where seawater carbonate chemistry generally shows strong diel variations with higher pH but lower partial pressure of CO 2 ( p CO 2 ) during the daytime and lower pH but higher p CO 2 during nighttime due to the alternation in photosynthesis and respiration, the seagrass meadows of the inner lagoon (IL) on Dongsha Island had a unique diel pattern with extremely high pH and low p CO 2 across a diel cycle. We suggest that this distinct diel pattern in pH and p CO 2 could be associated with the enhancement of total alkalinity (TA) production coupled to carbonate sediment dissolution in a semienclosed lagoon. The confinement of the IL may hamper water exchange and seagrass detritus export to the adjacent open ocean, which may result in higher organic matter loading to the sediments, and longer residence time of the water in the IL, accompanied by microbial respiration (both aerobic and anaerobic) that may reduce carbonate saturation level to drive carbonate dissolution and thus TA elevation, thereby forming such a unique diel pattern in carbonate chemistry. This finding further highlights the importance of considering TA production through metabolic carbonate dissolution when evaluating the potential of coastal blue carbon ecosystems to buffer ocean acidification and to absorb atmospheric CO 2 , in particular in a semienclosed setting.

Isolation of evolvulic acids B and C, two new components of crude resin glycoside fraction from Evolvulus alsinoides - Jin-Yuan Xu; Ye He; Ai-Wen Zhang; Yun Lu; Guang-Tong Chen; Min Yang; Bo-Yi Fan (Natural Product Research, 2021)

Lead-lag correlations between snow cover and meteorological factors at multi-time scales in the Tibetan Plateau under climate warming - Xiao Qiao; Jintao Liu; Shuhong Wang; Jiarong Wang; Haijuan Ji; Xi Chen; Hu Liu; Fan Lu (Theoretical and Applied Climatology, 2021)

Linking circular intronic RNA degradation and function in transcription by RNase H1 - Xiang Li; Jia-Lin Zhang; Yun-Ni Lei; Xiao-Qi Liu; Wei Xue; Yang Zhang; Fan Nan; Xiang Gao; Jun Zhang; Jia Wei; Li Yang; Ling-Ling Chen (Science China Life Sciences, 2021)

Lipin1 Alleviates Autophagy Disorder in Sciatic Nerve and Improves Diabetic Peripheral Neuropathy - Meijian Wang; Min Xie; Shuyan Yu; Pan Shang; Cong Zhang; Xiaolin Han; Cuiqin Fan; Li Chen; Xianghua Zhuang; Shihong Chen (Molecular Neurobiology, 2021)

Dexmedetomidine Alleviates Lipopolysaccharide-Induced Hippocampal Neuronal Apoptosis via Inhibiting the p38 MAPK/c-Myc/CLIC4 Signaling Pathway in Rats - Yongping Chen; Lin Li; Jiuyan Zhang; Hailin Cui; Jiucheng Wang; Chuqiao Wang; Mingxian Shi; Honggang Fan (Molecular Neurobiology, 2021)

Performance Evaluation of BDS/GPS Combined Single Point Positioning with Low-cost Single-Frequency Receiver - Qinglin Guan; Chunming Fan; Guangyong Chen; Chongcheng Chen (Journal of the Indian Society of Remote Sensing, 2021)

Risk factors for recurrent positive results of the nucleic acid amplification test for COVID-19 patients: a retrospective study - Wanwan Yi; Xuan Long; Jin Liu; LiShuai Shi; Zichen Chen; Jing Yang; Ziyu Yang; Zhongwei Lv; Hengwei Fan (Human Cell, 2021)
Positive retests of COVID-19 represent a public health concern because of the increased risk of transmission. This study explored whether factors other than the nucleic acid amplification test (NAAT) contribute to positive retest results. Patients with COVID-19 admitted to the Guanggu district of the Hubei Maternal and Child Health Hospital between February 17 and March 28, 2020, were retrospectively included. The patients were grouped into the negative ( n = 133) and positive ( n = 51) retest groups. The results showed that the proportion of patients presenting with cough was higher ( P < 0.001) and the proportion of patients with dyspnea was lower ( P = 0.018) in the positive than in the negative retest group. The positive retest group showed shorter durations between symptom onset and hospitalization ( P < 0.001) and symptom onset and the first positive NAAT ( P = 0.033). The positive retest group had higher basophil counts ( P = 0.023) and direct bilirubin ( P = 0.032) and chlorine concentrations ( P = 0.023) but lower potassium concentrations ( P = 0.001) than the negative retest group. Multivariable regression analysis showed that coughing (OR = 7.59, 95% CI 2.28–25.32, P = 0.001) and serum chloride concentrations (OR = 1.38, 95% CI 1.08–1.77, P = 0.010) were independently associated with a positive retest result. Coughing and serum chloride concentrations were independent risk factors for positive NAAT retest results. Patients with a hospital stay of < 2 weeks or a short incubation period should stay in isolation and be monitored to reduce transmission. These results could help identify patients who require closer surveillance.

Effects of carbonaceous materials and particle size on oral and inhalation bioaccessibility of PAHs and OPEs in airborne particles - Yuan Zeng; Shejun Chen; Yun Fan; Qiqi Li; Yufeng Guan; Bixian Mai (Environmental Science and Pollution Research, 2021)

Warm season temperature in the Qinling Mountains (north-central China) since 1740 CE recorded by tree-ring maximum latewood density of Shensi fir - Feng Chen; Mary H. Gagen; Heli Zhang; Youping Chen; Ziang Fan; Fahu Chen (Climate Dynamics, 2021)