Dissection of the practical soybean breeding pipeline by developing ZDX1, a high-throughput functional array - Rujian Sun; Bincheng Sun; Yu Tian; Shanshan Su; Yong Zhang; Wanhai Zhang; Jingshun Wang; Ping Yu; Bingfu Guo; Huihui Li; Yanfei Li; Huawei Gao; et al. (Theoretical and Applied Genetics, 2022)
Key message We developed the ZDX1 high-throughput functional soybean array for high accuracy evaluation and selection of both parents and progeny, which can greatly accelerate soybean breeding. Abstract Microarray technology facilitates rapid, accurate, and economical genotyping. Here, using resequencing data from 2214 representative soybean accessions, we developed the high-throughput functional array ZDX1, containing 158,959 SNPs, covering 90.92% of soybean genes and sites related to important traits. By application of the array, a total of 817 accessions were genotyped, including three subpopulations of candidate parental lines, parental lines and their progeny from practical breeding. The fixed SNPs were identified in progeny, indicating artificial selection during the breeding process. By identifying functional sites of target traits, novel soybean cyst nematode-resistant progeny and maturity-related novel sources were identified by allele combinations, demonstrating that functional sites provide an efficient method for the rapid screening of desirable traits or gene sources. Notably, we found that the breeding index (BI) was a good indicator for progeny selection. Superior progeny were derived from the combination of distantly related parents, with at least one parent having a higher BI. Furthermore, new combinations based on good performance were proposed for further breeding after excluding redundant and closely related parents. Genomic best linear unbiased prediction (GBLUP) analysis was the best analysis method and achieved the highest accuracy in predicting four traits when comparing SNPs in genic regions rather than whole genomic or intergenic SNPs. The prediction accuracy was improved by 32.1% by using progeny to expand the training population. Collectively, a versatile assay demonstrated that the functional ZDX1 array provided efficient information for the design and optimization of a breeding pipeline for accelerated soybean breeding.

Moment Tensor Inversion and Stress Evolution of Coal Pillar Failure Mechanism - Chun-Hui Song; Cai-Ping Lu; Xiu-Feng Zhang; Chao Wang; Hua-Dong Xie; Xian-Yang Yan; Hong-Wei Yang (Rock Mechanics and Rock Engineering, 2022)

A Preliminary Study on the Evaluation of Human Sperm Head Morphology with a Domestic Digital Holographic Image System - Hong Zhu; Yong Zhu; Can Sun; Feng Jiang (Phenomics, 2022)

Dissecting the Neural Circuitry for Pain Modulation and Chronic Pain: Insights from Optogenetics - Fang Guo; Yu Du; Feng-Hui Qu; Shi-Da Lin; Zhong Chen; Shi-Hong Zhang (Neuroscience Bulletin, 2022)
Pain is an unpleasant sensory and emotional experience associated with, or resembling that associated with, actual or potential tissue damage. The processing of pain involves complicated modulation at the levels of the periphery, spinal cord, and brain. The pathogenesis of chronic pain is still not fully understood, which makes the clinical treatment challenging. Optogenetics, which combines optical and genetic technologies, can precisely intervene in the activity of specific groups of neurons and elements of the related circuits. Taking advantage of optogenetics, researchers have achieved a body of new findings that shed light on the cellular and circuit mechanisms of pain transmission, pain modulation, and chronic pain both in the periphery and the central nervous system. In this review, we summarize recent findings in pain research using optogenetic approaches and discuss their significance in understanding the pathogenesis of chronic pain.

Sodium tanshinone IIA sulfonate improves cognitive impairment via regulating Aβ transportation in AD transgenic mouse model - Hui-Han Ma; Can Wan; Lu-Di Zhang; Rong-Rong Zhang; Dong Peng; Li-Jun Qiao; Shi-Jie Zhang; Ye-Feng Cai; Hong-Qiang Huang (Metabolic Brain Disease, 2022)

Isolation and characterization of a long-type mutant in Phycocalidia suborbiculata - Pei-Feng Shi; Hong-Chang Ding; Shuang Zhao; Chen-Hui Zhong; Xing-Hong Yan (Journal of Applied Phycology, 2022)

Electrochemical enhancement of high-efficiency wet removal of mercury from flue gas - Nai-jiao Xu; Sen Li; Yu-hong Fu; Zhao-yang Wang; Li-juan Feng; Ji Wang (Environmental Science and Pollution Research, 2022)

Transformation processes of biogenic dimethylated sulfur compounds in the northwestern Pacific continental sea - Qian‐Yao Ma; Hong‐Hai Zhang; Feng Xu; Gui‐Peng Yang (Limnology and Oceanography, 2022)
Biogenic dimethylated sulfur compounds, comprising dimethylsulfide (DMS), dimethylsulfoniopropionate (DMSP), and dimethylsulfoxide, play a vital role in the physiological metabolism processes of marine algae, climate regulation, and global sulfur cycles, but the contribution of each transformation pathway and the factors that control them remain uncertain. For the first time, from 27 March 2017 to 15 April 2017, the rates of major transformation pathways of biogenic dimethylated sulfur compounds and the fluxes of DMS at the sea–air and seawater–sediment interfaces were measured simultaneously in the East China Continental Sea. Rapid biological turnover times of total DMSP (0.53 d), dissolved DMSP (0.29 d), and DMS (0.43 d) were observed, indicating that DMS and DMSP were renewed more than twice daily. Bacterial consumption contributed nearly 50% of the total DMSP loss, approximately 38% of which was converted into DMS. Microbial consumption, photolysis, and ventilation accounted for 56%, 34%, and 10% of DMS removal processes, respectively. Sediment had a small but positive flux of DMS, making the sediment‐seawater interface a tiny source of DMS to the water column. Finally, although only about 10% of DMS was emitted to the atmosphere, the study region was identified as a “hotspot” for atmospheric DMS. The DMS budget model of the mixed layer developed in this study has provided a systematic and comprehensive understanding of the organosulfur cycle in continental shelf seas.

Changes in compound hot and dry day and population exposure across China under climate change - Yao Feng; Fubao Sun; Wenbin Liu; Jie Chen; Hong Wang; Qiang Guo; Yang Wang; Qiang Zhang; Yan‐Fang Sang (International Journal of Climatology, 2022)
Hot and dry extremes have co‐occurred with global warming, causing worse threats than single climate extremes. We analyse the compound hot and dry day (CHDD) and population exposure ( E pop ) across China based on observations and 11 global climate models (GCMs) from the Coupled Model Intercomparison Project Phase 6. The bias‐corrected GCMs, particularly the two‐stage multivariate quantile mapping‐corrected ones, perform better than the raw ones in catching changes in CHDD but they all overestimate CHDD and E pop . More CHDDs occur in the southeast (SE), north (NC) and northwest (NW) China with increasing trends over regions stretching from the northeast (NE) to southwest (SW) China. Despite the declined CHDD, historical E pop has generally increased by the increased population. Future projections in the SSP5‐8.5 experiment indicate an overall increase of CHDD and E pop at 1.5°C warming and an increasing E pop to dangerous CHDD at 2°C warming. SW, NE and the Tibetan Plateau need effective measures of adaptation to reduce sufferings from CHDD under climate change.

Diketopiperazine and enterotoxin analogues from the mangrove derived-soil Streptomyces sp. SCSIO 41400 and their biological evaluation - Meng-Meng Song; Yu-Hui Xie; Wei-Hao Chen; Yi-Wei Hu; Kai Zhao; Yong-Hong Liu; Xiao-Long Huang; Qing-Chao Liu; Jun-Feng Wang (Natural Product Research, 2022)

Inhibition of TRPM2 by AG490 Is Neuroprotective in a Parkinson’s Disease Animal Model - Ana Flávia Fernandes Ferreira; Monique Patricio Singulani; Henning Ulrich; Zhong-Ping Feng; Hong-Shuo Sun; Luiz Roberto Britto (Molecular Neurobiology, 2022)

Whole genome re-sequencing reveals the genetic diversity and evolutionary patterns of Eucommia ulmoides - Jun Qing; Yi-De Meng; Feng He; Qing-Xin Du; Jian Zhong; Hong-Yan Du; Pan-Feng Liu; Lan-Ying Du; Lu Wang (Molecular Genetics and Genomics, 2022)

Development and characterization of composition-equivalent formulations to the Sandostatin LAR® by the solvent evaporation method - Avital Beig; Linglin Feng; Jennifer Walker; Rose Ackermann; Justin K. Y. Hong; Tinghui Li; Yan Wang; Steven P. Schwendeman (Drug Delivery and Translational Research, 2022)

Analysis of Threshold Effect of Urinary Heavy Metal Elements on the High Prevalence of Nephrolithiasis in Men - Yalan Liu; Cailiang Zhang; Zixiu Qin; Qianyuan Yang; Juan Lei; Xuejie Tang; Qiaorong Wang; Feng Hong (Biological Trace Element Research, 2022)

Family History of Hypertension and Cobalt Exposure Synergistically Promote the Prevalence of Hypertension - Cailiang Zhang; Qibing Zeng; Yalan Liu; Zixiu Qin; Leilei Liu; Junyan Tao; Linyuan Zhang; Qianyuan Yang; Juan Lei; Xuejie Tang; Qiaorong Wang; Liubo Zheng; et al. (Biological Trace Element Research, 2022)

Local adaptation and migratory habits balance spatial‐genetic structure between continental and insular chestnut tiger butterflies in East Asia - Min‐Xin Luo; Hsin‐Pei Lu; Bing‐Hong Huang; Chia‐Lung Huang; Yu‐Feng Hsu; Pei‐Chun Liao (Molecular Ecology, 2022)
Geographic and climatic differences between islands and continents may affect the evolution of their biota, and promote divergent selection in species distributed in both landscapes. To assess spatial‐genetic structure, we genotyped 18 expressed sequence tag‐simple sequence repeat (EST‐SSR) loci and sequenced two mtDNA markers ( ND5 and COI ) and one nuclear marker ( EF1α ) in two subspecies of the butterfly Parantica sita . Compared with nuclear markers, mtDNA had a stronger signal of population structure. Approximate Bayesian computation (ABC) suggested that a continuous‐gene‐flow model best described the data. According to this model, the two subspecies diverged approximately 23.1 kya, with 10 times more introgression from the continental (ssp. sita ) to the insular subspecies (ssp. niphonica ) than vice versa. Ecological niche modelling was performed to predict the paleo‐ and current potential distributions and elucidate the geohistorical process, which revealed a northeastern, insular origin. Winter precipitation and annual temperature range were the main determinants of the subspecies distributions. Maximum‐likelihood population‐effects models showed that the population differentiation of the insular and continental subspecies was primarily affected by environmental resistance and local climate. Sex‐biased migration capacity and long‐term precipitation‐driven divergence between the continental and insular lineages shaped the current genetic structure of P . sita . Evidence from the nuclear markers confirmed intersubspecific gene flow despite adaptive divergence between the subspecies. These results imply that the continental subspecies is still capable of returning to the island and introgressing with the insular subspecies.

Design, synthesis and agricultural evaluation of derivatives of N-Acyl-N-(m-fluoro-benzyl)-6-amino-coumarin - Yan Jin; Yin-hao Ding; Jing-jing Dong; Yan Wei; Shuang-hong Hao; Bai-cheng Feng (Natural Product Research, 2022)

Production of dimethyl sulfide and acrylic acid from dissolved dimethylsulfoniopropionate during the growth of Prorocentrum minimum - Pei-Feng Li; Pei-Pei Gao; Chun-Ying Liu; Hong-Hai Zhang; Gui-Peng Yang (Journal of Applied Phycology, 2022)

Correction to: A native Trichoderma harzianum strain Th62 displays antagonistic activities against phytopathogenic fungi and promotes the growth of Celosia cristata - Xue-Yue Hou; Yue-Feng Wang; Chuan-Ying Jiang; Tong-Tong Zhai; Rui Miao; Jun-Jie Deng; Zhi-Hong Yao; Rong-Shu Zhang (Horticulture, Environment, and Biotechnology, 2022)

Deformation Mechanism and Control Ttechnology of Surrounding Rock of the Roadway in a Steep Coal seam - Tu Hong-sheng; Liu Song-yong; Huang Chang-wen; Guo Chen-ye; Zhang Xiao-bo; You Zu-feng (Geotechnical and Geological Engineering, 2022)

Genetic diversity among a collection of bitter gourd (Momordica charantia L.) cultivars - Junjie Cui; Yinhui Zhou; Jian Zhong; Chengcheng Feng; Yu Hong; Kailin Hu; Yi Cao (Genetic Resources and Crop Evolution, 2022)

Association between non-optimal temperature and hospitalizations for gout in Anqing, China: a time-series analysis - Yi-Sheng He; Gui-Hong Wang; Zheng-Dong Wu; Napoleon Bellua Sam; Yue Chen; Jin-Hui Tao; Xin-Yu Fang; Zhiwei Xu; Hai-Feng Pan (Environmental Science and Pollution Research, 2022)

Control of chronic obstructive pulmonary disease in urban populations: findings from a cross-sectional prevalence survey in Shenzhen, China - Le-Cai Ji; Jin-Feng Yin; Chun-Rong Lu; Hong-Yun Guan; Wei-Guo Tan; Ling-Wei Wang; Qi Jiang (Environmental Science and Pollution Research, 2022)

Association between exposure to ambient air pollution and semen quality in adults: a meta-analysis - Hong Qian; Qiaoqiao Xu; Wenkai Yan; Yun Fan; Zhi Li; Chengzhe Tao; Feng Zhang; Chuncheng Lu (Environmental Science and Pollution Research, 2022)

Accurate Determination of Zr Isotopic Ratio in Zircons by Femtosecond Laser Ablation MC-ICP-MS with “Wet” Plasma Technique - Wen Zhang; Zhaochu Hu; Lanping Feng; Zaicong Wang; Yongsheng Liu; Yantong Feng; Hong Liu (Journal of Earth Science, 2022)
This work evaluates the use of femtosecond laser ablation multiple collector inductively coupled plasma mass spectrometry (fs-LA-MC-ICP-MS) for Zr isotopic analysis in zircons. The mass fractionation caused by instrumental mass discrimination was corrected by a combination of internal correction using Sr as an internal standard (coming from a NIST SRM 987 standard solution) and external correction using a matrix-matched standard. Several important instrument parameters were investigated, such as the effect of the addition of N 2 and “wet” plasma condition, the mass fractionation behaviors between Zr isotopes and Sr isotopes, the position effect in laser ablation cell and the effect of laser ablation parameters (laser spot size and energy density). The Zr isotope compositions of seven zircons (GJ-1, 91500, Plešovice, Rak-17, Paki, Aus and Mala) were determined by the developed fs-LA-MC-ICP-MS and thermal ionization mass spectrometry (TIMS). Our fs-LA-MC-ICP-MS results for Zr isotope compositions agreed with TIMS analyses within analytical uncertainties, indicating the presented method is a suitable tool to resolve isotopic zoning in natural zircons. The results also suggest that GJ-1, 91500, Plešovice, Paki, Aus and Mala had the homogenous Zr isotope composition and could be considered as the potential candidates for the Zr isotope analysis in zircons, except Rak-17 which presented the large Zr isotope variation.

Three new phomalone derivatives from a deep-sea-derived fungus Alternaria sp. MCCC 3A00467 - Tian-Hua Zhong; Xian-Ming Zeng; Shi-Biao Feng; Hai-Tao Zhang; Yong-Hong Zhang; Zhu-Hua Luo; Wei Xu; Xin-Hua Ma (Natural Product Research, 2022)

Cloning and expression analysis of the HSL gene in Whitmania pigra (Annelida: Hirudinea) - Li-Yuan Guo; Qiao-Sheng Guo; Hong-Zhuan Shi; Feng Yang; Yi-Xiu Miao (Invertebrate Reproduction & Development, 2022)

A new analytical mode and application of the laser ablation inductively coupled plasma mass spectrometer in the earth sciences - Yantong Feng; Wen Zhang; Zhaochu Hu; Yongsheng Liu; Tao Luo; Tao He; Hong Liu; Kun Yu (Science China Earth Sciences, 2022)

Ferrostatin-1 Alleviates White Matter Injury Via Decreasing Ferroptosis Following Spinal Cord Injury - Hongfei Ge; Xingsen Xue; Jishu Xian; Linbo Yuan; Long Wang; Yongjie Zou; Jun Zhong; Zhouyang Jiang; Jiantao Shi; Tunan Chen; Hong Su; Hua Feng; et al. (Molecular Neurobiology, 2022)

Nitric Oxide Signaling Pathway in Ventral Tegmental Area is Involved in Regulation of 7,8-Dihydroxyflavone on Alcohol Consumption in Rats - Qing Gao; Tao Yang; Xin-Xin Li; Jun-Wei Xiong; Wei Ma; Yan-Min Xu; Yong Liu; Hong-Yan Zhang; Qi-Yu Wang; Hong-Xuan Wang; Ying Peng; Xiao-Feng Zhu; et al. (Molecular Neurobiology, 2022)

Design and synthesis of caffeic acid derivatives and evaluation of their inhibitory activity against Pseudomonas aeruginosa - Yun-feng Zeng; Ya-lun Su; Wei-liang Liu; Hong-geng Chen; Shao-gao Zeng; Hai-bo Zhou; Wei-min Chen; Jun-xia Zheng; Ping-hua Sun (Medicinal Chemistry Research, 2022)

YAP regulates porcine skin-derived stem cells self-renewal partly by repressing Wnt/β-catenin signaling pathway - Hong-Chen Yan; Yu Sun; Ming-Yu Zhang; Shu-Er Zhang; Jia-Dong Sun; Paul W. Dyce; Francesca Gioia Klinger; Massimo De Felici; Wei Shen; Shun-Feng Cheng (Histochemistry and Cell Biology, 2022)

Regulatory role of miR-129 and miR-384-5p on apoptosis induced by oxygen and glucose deprivation in PC12 cell - Hui-Lin Guan; Yue Guan; Wen-Yuan Li; Jia-Wei Liu; Yu-Jia Zheng; Yan-Zhong Guan; Hong-Feng Liu; Li-Xin Guan; Feng-Guo Zhai (Experimental Brain Research, 2022)

Adenine base-editing-mediated exon skipping induces gene knockout in cultured pig cells - Xiang-xing Zhu; Jia-sheng Pan; Tao Lin; Ye-cheng Yang; Qiu-yan Huang; Shuai-peng Yang; Zi-xiao Qu; Zi-sheng Lin; Jian-cong Wen; Ai-fen Yan; Juan Feng; Lian Liu; et al. (Biotechnology Letters, 2022)

The embodiment of the strategy of “using active chemicals as excipients” in compound preparation - Rizhao Yang; Yanlong Hong; Youjie Wang; Lijie Zhao; Lan Shen; Yi Feng (Journal of Pharmaceutical Investigation, 2022)

Antioxidant CPA-type indole alkaloids produced from the deep-sea derived fungus Aspergillus sp. SCSIO 41024 - Wei-Hao Chen; Kun-Long Li; Xiu-Ping Lin; Sheng-Rong Liao; Bin Yang; Xue-Feng Zhou; Jun-Jian Wang; Yong-Hong Liu; Jun-Feng Wang (Natural Product Research, 2021)

Ifenprodil Improves Long-Term Neurologic Deficits Through Antagonizing Glutamate-Induced Excitotoxicity After Experimental Subarachnoid Hemorrhage - Jing-yi Sun; Shi-jun Zhao; Hong-bin Wang; Ya-jun Hou; Qiong-jie Mi; Ming-feng Yang; Hui Yuan; Qing-bin Ni; Bao-liang Sun; Zong-yong Zhang (Translational Stroke Research, 2021)

Sigma-1 Receptor Activation Suppresses Microglia M1 Polarization via Regulating Endoplasmic Reticulum–Mitochondria Contact and Mitochondrial Functions in Stress-Induced Hypertension Rats - Kokwin Ooi; Li Hu; Yi Feng; Chenzhi Han; Xiaorong Ren; Xinyi Qian; Haofeng Huang; Sijia Chen; Qi Shi; Hong Lin; Jijiang Wang; Danian Zhu; et al. (Molecular Neurobiology, 2021)

The role of carbonic anhydrase III and autophagy in type 2 diabetes with cardio-cerebrovascular disease - Xiao-Ming Zhang; Ying-Hong Tao; Xiu-Ling Zhou; Xi-Liang Shang; Xiao-Bo Gong; Ying-Chao Liu; Yan-Yan Huang; Gang Chen; Zhong-Yu Yu; Jian-Tao Wang; Zun-Guo Du; Guo-Feng Wu; et al. (Metabolic Brain Disease, 2021)
Type 2 diabetes mellitus (T2DM) is one of the most common chronic diseases among the elderly people. The T2DM increases the risk of cardio-cerebrovascular disease (CCD), and the main pathological change of the CCD is atherosclerosis (AS). Meanwhile, the carbonic anhydrases (CAs) are involved in the formation and progression of plaques in AS. However, the exact physiological mechanism of carbonic anhydrase III (CAIII) has not been clear yet, and there are also no correlation study between CAIII protein and T2DM with CCD. The 8-week old diabetic mice (db/db −/− mice) and wild-type mice (wt mice) were feed by a normal diet till 32 weeks, and detected the carotid artery vascular opening angle using the method of biomechanics; The changes of cerebral cortex and myocardium were watched by the ultrastructure, and the autophagy were observed by electron microscope; The tissue structure, inflammation and cell injury were observed by Hematoxylin and eosin (HE) staining; The apoptosis of cells were observed by TUNEL staining; The protein levels of CAIII, IL-17, p53 were detected by immunohistochemical and Western Blot, and the Beclin-1, LC3, NF-κB were detected by Western Blot. All statistical analysis is performed using PRISM software. Compared with wt mice, db/db −/− mice’ carotid artery open angle increased significantly. Electron microscope results indicated that autophagy in db/db −/− mice cerebral cortex and heart tissue decreased and intracellular organelle ultrastructure were damaged. HE staining indicated that, db/db −/− mice’ cerebral cortex and heart tissue stained lighter, inflammatory cells infiltration, cell edema were obvious, myocardial fibers were disorder, and myocardial cells showed different degrees of degeneration. Compared with wt mice, TUNEL staining showed that there was obviously increase in db/db −/− mice cortex and heart tissue cell apoptosis. The results of immunohistochemistry and Western Blot indicated that CAIII, Beclin-1 and LC3II/I expression levels conspicuously decreased in cortex and heart tissue of db/db −/− mice, and the expression level of IL-17, NF-κB and p53 obviously increased. The carotid artery’ vascular stiffness was increased and which was probably related with formation of AS in diabetic mice. And the autophagy participated in the occurrence and development of diabetic CCD. CAIII protein might somehow be involved in the regulation of autophagy probably through affecting cell apoptosis and inflammation, but the underlying mechanism remains to be further studied.

Gene expression profiles in the brain of phenylketonuria mouse model reversed by the low phenylalanine diet therapy - Sha Hong; Tianwen Zhu; Simin Zheng; Xia Zhan; Feng Xu; Xuefan Gu; Lili Liang (Metabolic Brain Disease, 2021)

Hydrogen Sulfide Maintains Good Nutrition and Delays Postharvest Senescence in Postharvest Tomato Fruits by Regulating Antioxidative Metabolism - Ting-Ying Zhong; Gai-Fang Yao; Sha-Sha Wang; Ting-Ting Li; Ke-Ke Sun; Jun Tang; Zhong-Qin Huang; Feng Yang; Yan-Hong Li; Xiao-Yan Chen; Lan-Ying Hu; Hua Zhang; et al. (Journal of Plant Growth Regulation, 2021)

Characterization of the novel hybrid cultivar E25 of Saccharina japonica in the northern farming region of China - Li Su; Ti Feng Shan; Jing Li; Su Qin Gao; Shao Jun Pang; Xiao Fei Leng; Yan Zhang; Ming Fu Zhang; Hong Tao Gao (Journal of Applied Phycology, 2021)

External evaluation of published population pharmacokinetic models of polymyxin B - Ya-qian Li; Kai-feng Chen; Jun-jie Ding; Hong-yi Tan; Nan Yang; Ya-qi Lin; Cui-fang Wu; Yue-liang Xie; Guo-ping Yang; Jing-Jing Liu; Qi Pei (European Journal of Clinical Pharmacology, 2021)

Critical Risk Indicators (CRIs) for the electric power grid: a survey and discussion of interconnected effects - Judy P. Che-Castaldo; Rémi Cousin; Stefani Daryanto; Grace Deng; Mei-Ling E. Feng; Rajesh K. Gupta; Dezhi Hong; Ryan M. McGranaghan; Olukunle O. Owolabi; Tianyi Qu; Wei Ren; Toryn L. J. Schafer; et al. (Environment Systems and Decisions, 2021)

Study on origin, classification, and identification of complex porous carbonate reservoir: a case study of the middle cretaceous Mishrif Formation in W Oil field - Xinxin Fang; Hong Feng; Hao Wang; Yunhong Wang (Carbonates and Evaporites, 2021)

Study on the Pyrolysis Characteristics, Kinetics and Mineral Transformation of Paper Sludge - Yanshan Yin; Huixia Yin; Zihan Yuan; Zihua Wu; Wei Zhang; Hong Tian; Leihua Feng; Shan Cheng; Mengxia Qing; Quanbin Song (BioEnergy Research, 2021)

Seismic velocity inversion based on CNN-LSTM fusion deep neural network - Cao Wei; Guo Xue-Bao; Tian Feng; Shi Ying; Wang Wei-Hong; Sun Hong-Ri; Ke Xuan (Applied Geophysics, 2021)

Three-dimensional gravity inversion based on 3D U-Net++ - Wang Yu-Feng; Zhang Yu-Jie; Fu Li-Hua; Li Hong-Wei (Applied Geophysics, 2021)

Chemical constituents from the barks of Melia azedarach and their PTP1B inhibitory activity - Sheng-Nan Zhang; Lin Huang; Rui-Jing Ma; Mei-Feng Yang; Ben-Fu Wei; Hong-Zhi Song; Heng-Shan Wang; Qin-Gang Tan (Natural Product Research, 2021)

Phyllanthacidoid U: a new N -glycosyl norbisabolane sesquiterpene from Phyllanthus acidus (L.) skeels - Ying Xin; Min Xu; Ya-Feng Wang; Xiao-Hong Zheng; Hong-Tao Zhu; Dong Wang; Chong-Ren Yang; Ying-Jun Zhang (Natural Product Research, 2021)

Two new phenylpropanoids and a new dihydrostilbenoid from the flower buds of Magnolia biondii pamp and their acetylcholinesterase inhibitory activities - Yan-Gang Cao; Hong-Wei Li; Bing Cao; Jian-Chao Wang; Yan-Li Zhang; Xuan Zhao; Xiao-Ke Zheng; Wei-Sheng Feng (Natural Product Research, 2021)

A landslide in Heifangtai, northwest of the Chinese Loess Plateau: triggered factors, movement characteristics, and failure mechanism - Jia-xu Kong; Jian-qi Zhuang; Jie-wei Zhan; Zheng-wei Bai; Yan-qiu Leng; Peng-hui Ma; Jian-bing Peng; Zuo-peng Wang; Tian-feng Gu; Jia-xing Sun; Fan-chen Zhang; Yuan-jun Xu; et al. (Landslides, 2021)

Emerging role of air pollution in chronic kidney disease - Yue Chen; Fan Cao; Jian-Ping Xiao; Xin-Yu Fang; Xue-Rong Wang; Li-Hong Ding; De-Guang Wang; Hai-Feng Pan (Environmental Science and Pollution Research, 2021)

Blocking retrograde axonal transport of autophagosomes contributes to sevoflurane-induced neuron apoptosis in APP/PS1 mice - Mingliang Xu; Jianguo Feng; Mingxi Tang; Qingxi Guo; Jian Zhan; Fuzu Zhu; Hong Lei; Qingmei Kang (Acta Neurologica Belgica, 2021)
Autophagy, a crucial pathway for the degradation of proteins in eukaryotic cells, is linked to the development of Alzheimer’s disease (AD), and the accumulated autophagosomes in the cells resulting in the death of cells. Sevoflurane can impair spatial learning and memory in mice with AD and lead to the apoptosis of nerve cells; however, the underlying mechanisms remain unknown. We aim to explore the effects and underlying mechanisms of sevoflurane in APPswe/PS1ΔE9 double-transgenic mice. 51 heterozygous APPswe/PS1ΔE9 double-transgenic mice were involved and divided into three groups, including control group, sham group and sevoflurane group. Morris water maze experiment was used to test the learning and memory abilities of mice, flow cytometry was conducted to detect apoptosis and mitochondrial membrane potential of brain cells in mice, transmission electron microscopy was used to observe the number of autophagosomes at the axon in mice, and western blot was carried out to detect the expression of Bax, Bcl-2, LC3II, P62, KIF3B and DIC proteins of brain cells in mice. In our study, we found that significantly longer escape latencies, fewer crossings of the platform and shorter time spent in the target quadrant of the morris water maze experiment in the sevoflurane group. Flow cytometry showed cellular apoptosis was increased and the membrane potential of the mitochondria was reduced of brain cells in the sevoflurane group. Transmission electron microscopy displayed that there was a remarkable upregulation of autophagosomes at the axon of brain cells in mice after treatment of sevoflurane. Western blot demonstrated that the expression of Bax, LC3II, P62 and KIF3B proteins were elevated, and the expression of Bcl-2 and DIC proteins were reduced in the sevoflurane group. Sevoflurane impaired acquisition learning and memory function, promoted the apoptosis of hippocampal neurons in APPswe/PS1ΔE9 double-transgenic mice, and the mechanism might be related to the activation of autophagy along with the disruption of autophagosomes retrograde transport in axons.

Melognine, a novel monoterpenoid indole alkaloid from Melodinus fusiformis that induce apoptosis in BT549 cells - Jie Zhou; Si-Yu Du; Zhong-Ying Fang; Jin-Hong Feng (Natural Product Research, 2021)

Bioactive terpenoids from Croton laui - Fei Li; Dong-Bo Zhang; Jing-Tao Li; Feng-Jie He; Hong-Li Zhu; Nan Li; Xin-Chun Xiao; Li Ren; Wei Zheng (Natural Product Research, 2021)

Lateral Habenula Serves as a Potential Therapeutic Target for Neuropathic Pain - Yu Du; Yu-Xing Wu; Fang Guo; Feng-Hui Qu; Ting-Ting Hu; Bei Tan; Yi Wang; Wei-Wei Hu; Zhong Chen; Shi-Hong Zhang (Neuroscience Bulletin, 2021)

Suppressive role of microRNA-130b-3p in ferroptosis in melanoma cells correlates with DKK1 inhibition and Nrf2-HO-1 pathway activation - Yangying Liao; Xiaomin Jia; Yi Ren; Zhuoga Deji; Yuzhen Gesang; Ning Ning; Hao Feng; Hong Yu; An Wei (Human Cell, 2021)

Application of the modified cytosine base-editing in the cultured cells of bama minipig - Jia-sheng Pan; Zi-sheng Lin; Jian-cong Wen; Jian-feng Guo; Xia-hui Wu; Ying-ying Liu; Wen-jun Lai; Qi-ying Liang; Yong-shi Xie; Yi-rou Chen; Yi-hong Chen; Ai-fen Yan; et al. (Biotechnology Letters, 2021)

The Individual and Synergistic Indexes for Assessments of Heavy Metal Contamination in Global Rivers and Risk: a Review - Hong-Giang Hoang; Chitsan Lin; Chow-Feng Chiang; Xuan-Thanh Bui; Wisanukorn Lukkhasorn; Thi-Phuong-Thuy Bui; Huu-Tuan Tran; Thi-Dieu-Hien Vo; Van-Giang Le; Long D. Nghiem (Current Pollution Reports, 2021)

Analytical solution to consolidation of accreting soil considering step load and horizontal drainage layers - Shi-Jin Feng; Wen-Tao Wang; Zhang-Long Chen; Hong-Xin Chen (Marine Georesources & Geotechnology, 2021)

Inhibition of PI4KIIIα as a Novel Potential Approach for Gaucher Disease Treatment - Linan Zheng; Feng Hong; Fude Huang; Wenan Wang (Neuroscience Bulletin, 2021)

Evaluation of soil microbial communities and enzyme activities in cucumber continuous cropping soil treated with spent mushroom (Flammulina velutipes) substrate - Hong-Wei Wang; Man Xu; Xiao-Yu Cai; Feng Tian (Journal of Soils and Sediments, 2021)

Evaluation of field resistance to brown stripe disease in novel and major cultivated sugarcane varieties in China - Xiao-Yan Wang; Xiao-Yan Cang; Wei Qin; Hong-Li Shan; Rong-Yue Zhang; Chang-Mi Wang; Wen-Feng Li; Ying-Kun Huang (Journal of Plant Pathology, 2021)

First report on Neofusicoccum kwambonambiense causing strawberry root rot on strawberry in China - Yijing Zhan; Wenjie Peng; Zongqi Xu; Xiaohai Feng; Hong Xu (Journal of Plant Pathology, 2021)

LncRNA AFAP1-AS1 promotes M1 polarization of macrophages and osteogenic differentiation of valve interstitial cells - Welai He; Hong Che; Chaolong Jin; Yanli Li; Feng Li; Ruyuan Zhou (Journal of Physiology and Biochemistry, 2021)

Screening and application of SSR markers related to seed storability traits in maize (Zea mays L.) - Xiaoyang Guo; Xiaohui Sun; Shan Liu; Chengxu Gong; Chenchen Feng; Xiao Han; Tingting Lv; Yu Zhou; Zhenhua Wang; Hong Di (Genetic Resources and Crop Evolution, 2021)

Safety evaluation and ibuprofen removal via an Alternanthera philoxeroides-based biochar - Yuan-da Du; Xin-qian Zhang; Li Shu; Yu Feng; Cui Lv; Hong-qiang Liu; Fei Xu; Qian Wang; Cong-cong Zhao; Qiang Kong (Environmental Science and Pollution Research, 2021)

A new ent -kaurane diterpene from Isodon henryi - Xue Jiang; Ling-Xia Zhang; Qing-Mei Feng; Hong Wu; Ya-Lin Liu; De-Qin Wang; Li-Ping Dai; Zhi-Min Wang (Natural Product Research, 2021)

Laboratory study of retention and clogging performance of no-fines concretes - Dong-Feng Zhu; Hong Cao; Hong Pan; Guan-Yong Luo (European Journal of Environmental and Civil Engineering, 2021)

A luminescent Zn(II)-Containing Complex: Selective Sensing of Cr(VI) Anion and Application Values on Tuberculosis Care Through Increasing the Antibacterial Response of Macrophages - Jin-Chao Mao; Jin-Jing Hong; Ming-Zheng Lin; Feng Han; Dong Li (Journal of Fluorescence, 2021)

Synthesis of magnetic core-shell amino adsorbent by using uniform design and response surface analysis (RSM) and its application for the removal of Cu2+, Zn2+, and Pb2+ - Easar Alam; Qiyan Feng; Hong Yang; Jiaxi Fan; Sameena Mumtaz (Environmental Science and Pollution Research, 2021)

Passive distributed temperature sensing (PDTS)-based moisture content estimation in agricultural soils under different vegetative canopies - Ding-feng Cao; Hong-hu Zhu; Chengchao Guo; Bing Wu; Jiachen Wang (Paddy and Water Environment, 2021)

Eutrophication regulation of Wuxing Lake based on eco-dynamics model - Feng Gao; Hong Cui; Suiju Lv; Ying Qiao (Arabian Journal of Geosciences, 2021)

Occurrence and cycle of dimethyl sulfide in the western Pacific Ocean - Feng Xu; Shi‐Bo Yan; Hong‐Hai Zhang; Ying‐Cui Wu; Qian‐Yao Ma; Yu‐Chen Song; Guang‐Chao Zhuang; Gui‐Peng Yang (Limnology and Oceanography, 2021)
Oceanic production and occurrence of dimethyl sulfide (DMS) and its subsequent ventilation to the atmosphere significantly contribute to the global sulfur cycle and impact the climate regulation. Spatial distributions of DMS, dimethylsulfoniopropionate (DMSP, precursor of DMS), and dimethyl sulfoxide (DMSO, oxidation product of DMS), production and removal processes of DMS (including biological production, microbial consumption, photo‐degradation, and sea‐to‐air exchange), and biogenic contributions to the atmospheric sulfate burden were simultaneously studied in the western Pacific Ocean during winter. Sea surface DMS, DMSP, and DMSO were strongly correlated and had similar distribution patterns. The DMS photo‐degradation efficiency ratio (normalized using incident photon flux density) for ultraviolet B radiation (UVB): ultraviolet A radiation (UVA): photosynthetically active radiation (PAR) was 391: 36: 1. However, considering the solar spectral composition, the actual contributions of UVB, UVA, and PAR to DMS photo‐degradation in surface waters were 40.6% ± 10.7%, 41.2% ± 15.6%, and 18.2% ± 7.2%, respectively. When integrated across the entire mixed layer, UVA and PAR became the dominant drivers, accounting for 45.2% ± 18.0% and 38.0% ± 17.3% of DMS photo‐degradation, respectively, as UVB was significantly attenuated in seawater. The DMS budget of the entire mixed layer indicated that microbial consumption, photo‐degradation, and ventilation accounted for about 74.3% ± 11.9%, 19.3% ± 9.3%, and 6.5% ± 4.0% of total DMS removal, respectively. Even if ventilation was a minor DMS removal pathway, DMS emissions still contributed approximately 45.2% ± 25.6% of the atmospheric non‐sea‐salt sulfate burden over the western Pacific Ocean.

DNA Methyltransferase 1 Is Dysregulated in Parkinson’s Disease via Mediation of miR-17 - Hong-Qiu Zhang; Jian-Yong Wang; Zhao-Feng Li; Lei Cui; Shi-Shi Huang; Lan-Bing Zhu; Yue Sun; Rui Yang; Hui-Hui Fan; Xiong Zhang; Jian-Hong Zhu (Molecular Neurobiology, 2021)

SR-B1 and CD10 combined immunoprofile for differential diagnosis of metastatic clear cell renal cell carcinoma and clear cell carcinoma of the ovary - Teng Jiang; Xiaoli Diao; Meili Ding; Xiao Niu; Chao Wang; Yan Qi; Wei Jia; Lijuan Pang; Wenhao Hu; Hong Zou; Feng Li (Journal of Molecular Histology, 2021)
Both clear cell renal carcinoma (ccRCC) and clear cell carcinoma of the ovary (CCOC) have a clear cytoplasmic morphological feature, hence it is difficult to identify metastatic ccRCC and CCOC by morphology alone. At present, there are no effective immunohistochemical markers to distinguish between these two tumors. Studies have shown that the clear cytoplasm of ccRCC is mainly caused by cholesterol-rich lipids in the cytoplasm, while that of CCOC is due to the accumulation of cytoplasmic glycogen. Objective: to hypothesize that the scavenger receptor class B-type 1 (SR-B1) protein responsible for HDL cholesterol uptake may be differentially expressed in ccRCC and CCOC, and high CD10 expression in the renal tubular epithelium may assist in distinguishing between ccRCC and CCOC. Methods: effective immunohistochemical markers were applied in 90 cases of renal clear cell carcinoma and 31 cases of ovarian cancer to distinguish between the two types of tumors.Result: SR-B1 and CD10 expression is significantly higher in ccRCC than CCOC. Both SR-B1 and CD10 exhibited focal weak-medium intensity staining in CCOC, and their staining extent and intensity were significantly lower than ccRCC. The sensitivity and specificity of SR-B1 for identifying ccRCC were 74.4% and 83.9%, respectively. The sensitivity and specificity of CD10 for identifying CCOC were 93.3% and 80.6%, respectively. The combined SR-B1( +) CD10( +) immunoprofile supports the diagnosis of ccRCC with a specificity of 93.5%. The combined SR-B1(-) CD10(-) immunoprofile supports the diagnosis of CCOC with a specificity of 93.3%. Conclusions: our findings demonstrate that the combination of SR-B1 and CD10 immunoprofiling is a valuable tool for differential diagnosis of ccRCC and CCOC.

Helios serves as a suppression marker to reduce regulatory T cell function in pancreatic cancer patients - Min-Feng Liu; Cheng Jin; Tao Wu; En-Hong Chen; Minxue Lu; Huan-Long Qin (Immunologic Research, 2021)

Performance of VITEK 2, E-test, Kirby–Bauer disk diffusion, and modified Kirby–Bauer disk diffusion compared to reference broth microdilution for testing tigecycline susceptibility of carbapenem-resistant K. pneumoniae and A. baumannii in a multicenter study in China - Dandan Yin; Yan Guo; Min Li; Wenjuan Wu; Jin Tang; Ying Liu; Feng Chen; Yuxing Ni; Jingyong Sun; Hong Zhang; Hu Zhao; Fupin Hu (European Journal of Clinical Microbiology & Infectious Diseases, 2021)

A modified method to calculate dual-isotope slopes for the natural attenuation of organic pollutants in the environment - Jin-Ru Feng; Hong-Gang Ni (Environmental Science and Pollution Research, 2021)

Investigating the spatial distribution of polychlorinated biphenyls in sediment in the Pearl River Delta, South China - Man-Ying Chen; Hong-Yin Liu; Xiao-Jun Luo; Bi-Xian Mai; Feng-Hui Lu (Environmental Monitoring and Assessment, 2021)

Continuous production of fructooligosaccharides by recycling of the thermal-stable β-fructofuranosidase produced by Aspergillus niger - Juan Wang; Jing Zhang; Lu Wang; Hong Liu; Ning Li; Huanxia Zhou; Zhanguo Ning; Weican Zhang; Lushan Wang; Feng Huang; Yaohua Zhong (Biotechnology Letters, 2021)

Abnormal degree centrality in lifelong premature ejaculation patients: an fMRI study - Ming Gao; Nana Feng; Xiang Liu; Jianhua Sun; Guangdong Hou; Lei Zhang; Hong Yin; Boda Guo; Jiayu Wu; Mengmeng Huang; Jianlin Yuan; Jun Guo; et al. (Brain Imaging and Behavior, 2021)

Efficient modeling of the gravity anomaly caused by a sedimentary basin with lateral variable density contrast and its application in basement relief estimation - Xu-Liang Feng; Sheng-Rong Liu; Hong-Yan Shen (Applied Geophysics, 2021)

HSV-1 H129-Derived Anterograde Neural Circuit Tracers: Improvements, Production, and Applications - Hong Yang; Feng Xiong; Yi-Ge Song; Hai-Fei Jiang; Hai-Bin Qin; Jing Zhou; Sha Lu; Steven F. Grieco; Xiangmin Xu; Wen-Bo Zeng; Fei Zhao; Min-Hua Luo (Neuroscience Bulletin, 2021)

Bjerkandera adusta M1 inhibits the growth of Fusarium oxysporum f. sp. conglutinans and fusarium wilt incidence in Brassica napus L. - Xiao Feng; Su-Ping Li; Yi-Fan Lu; Jing-Jie Zhang; Yun-Yun Zhu; Yong Li; Hong-Jun Yang; Xin-Hua He (Journal of Plant Pathology, 2021)

Genome-wide identification and expression analysis of the MADS-box transcription factor family in Camellia sinensis - Zai-Bao Zhang; Yuan-Jin Jin; Hou-Hong Wan; Lin Cheng; Zhi-Guo Feng (Journal of Applied Genetics, 2021)

Bi-allelic BRWD1 variants cause male infertility with asthenoteratozoospermia and likely primary ciliary dyskinesia - Ting Guo; Chao-Feng Tu; Dan-Hui Yang; Shui-Zi Ding; Cheng Lei; Rong-Chun Wang; Lv Liu; Xi Kang; Xiao-Qing Shen; Yi-Feng Yang; Zhi-Ping Tan; Yue-Qiu Tan; et al. (Human Genetics, 2021)

Ongoing COVID-19 Pandemic: A Concise but Updated Comprehensive Review - Chao Wang; Xiong Xiao; Hongyan Feng; Zhengyuan Hong; Meng Li; Ning Tu; Xuerong Li; Ke Wang; Lihong Bu (Current Microbiology, 2021)

Characteristics of soil erosion and sediment size distribution for different land uses in the Chinese Mollisol region - Hai-ou Shen; Jun Feng; Dong-li Wang; Hong-li Li; Yu Wang (Journal of Mountain Science, 2021)

B3GNT3 acts as a carcinogenic factor in endometrial cancer via facilitating cell growth, invasion and migration through regulating RhoA/RAC1 pathway-associated markers - Ji-Shui Wang; Fang Ruan; Li-Zhu Guo; Feng-Ge Wang; Fu-Ling Wang; Hong-Min An (Genes & Genomics, 2021)

Carotid Endarterectomy and Stenting in a Chinese Population: Safety Outcome of the Revascularization of Extracranial Carotid Artery Stenosis Trial - Bin Yang; Yan Ma; Tao Wang; Yanfei Chen; Yinzhou Wang; Zhenwei Zhao; Dong Chen; Jiyue Wang; Xiaolin Xu; Tao Luo; Yang Hua; Feng Ling; et al. (Translational Stroke Research, 2021)

Subcellular Localization of the D27 Protein in Sugarcane (Saccharum spp. Hybrids) Using an Optimized Protoplast Isolation, Purification, and Transient Gene Expression Protocol - Zhuan-di Wu; Xin Hu; Feng-gang Zan; Yong-bao Pan; David M. Burner; Zheng-ying Luo; Jia-yong Liu; Li-ping Zhao; Li Yao; Yong Zhao; Xin-long Liu; Hong-ming Xia; et al. (Sugar Tech, 2021)

DeepMapi: a Fully Automatic Registration Method for Mesoscopic Optical Brain Images Using Convolutional Neural Networks - Hong Ni; Zhao Feng; Yue Guan; Xueyan Jia; Wu Chen; Tao Jiang; Qiuyuan Zhong; Jing Yuan; Miao Ren; Xiangning Li; Hui Gong; Qingming Luo; et al. (Neuroinformatics, 2021)
The extreme complexity of mammalian brains requires a comprehensive deconstruction of neuroanatomical structures. Scientists normally use a brain stereotactic atlas to determine the locations of neurons and neuronal circuits. However, different brain images are normally not naturally aligned even when they are imaged with the same setup, let alone under the differing resolutions and dataset sizes used in mesoscopic imaging. As a result, it is difficult to achieve high-throughput automatic registration without manual intervention. Here, we propose a deep learning-based registration method called DeepMapi to predict a deformation field used to register mesoscopic optical images to an atlas. We use a self-feedback strategy to address the problem of imbalanced training sets (sampling at a fixed step size in nonuniform brains of structures and deformations) and use a dual-hierarchical network to capture the large and small deformations. By comparing DeepMapi with other registration methods, we demonstrate its superiority over a set of ground truth images, including both optical and MRI images. DeepMapi achieves fully automatic registration of mesoscopic micro-optical images, even macroscopic MRI datasets, in minutes, with an accuracy comparable to those of manual annotations by anatomists.

Retraction Note to: Effects of microRNA-21 on Nerve Cell Regeneration and Neural Function Recovery in Diabetes Mellitus Combined with Cerebral Infarction Rats by Targeting PDCD4 - Yun-Bao Guo; Tie-Feng Ji; Hong-Wei Zhou; Jin-Lu Yu (Molecular Neurobiology, 2021)

A native Trichoderma harzianum strain Th62 displays antagonistic activities against phytopathogenic fungi and promotes the growth of Celosia cristata - Xue-Yue Hou; Yue-Feng Wang; Chuan-Ying Jiang; Tong-Tong Zhai; Rui Miao; Jun-Jie Deng; Zhi-Hong Yao; Rong-Shu Zhang (Horticulture, Environment, and Biotechnology, 2021)

Increased depression risk for elderly women with high blood levels of strontium and barium - Jia Lv; Yan-ling Li; Wen-qiang Ren; Rong Li; Jian-rong Chen; Chao Bao; Zhi-ping Du; Shun Feng; Ling Gu; Hui Gao; Kai-yong Liu; Lin-sheng Yang; et al. (Environmental Chemistry Letters, 2021)

Retraction Note to: Soyasapogenol B exhibits anti-growth and anti-metastatic activities in clear cell renal cell carcinoma - Luping Wang; Junyu Wang; Hong Zhao; Guoping Jiang; Xiaojie Feng; Wenxia Sui; Hongling Liu (Naunyn-Schmiedeberg's Archives of Pharmacology, 2021)

Efficient Editing of an Adenoviral Vector Genome with CRISPR/Cas9 - Qiang Li; Hui Wang; Chen-yu Gong; Zhao Chen; Jia-xing Yang; Hong-wei Shao; Wen-feng Zhang (Indian Journal of Microbiology, 2021)

Recycling of subducted Indian continental crust and its significance on post-collisional ultrapotassic magmatism in southwestern Tibet - Izhar Sadiq; Fa-Bin Pan; Hong-Fei Zhang; Chun-Feng Li; Biji Luo; Mohammad Arif (Contributions to Mineralogy and Petrology, 2021)

The change of ecological service value and the promotion mode of ecological function in mountain development using InVEST model - Feng He; Jie Jin; Hong Zhang; Lei Yuan (Arabian Journal of Geosciences, 2021)

Constitutive Modeling of Physical Properties of Coastal Sand during Tunneling Construction Disturbance - Jian-Feng Zhu; Hong-Yi Zhao; Ri-Qing Xu; Zhan-You Luo; Dong-Sheng Jeng (Journal of Marine Science and Engineering, 2021)
This paper presents a simple but workable constitutive model for the stress–strain relationship of sandy soil during the process of tunneling construction disturbance in coastal cities. The model was developed by linking the parameter K and internal angle φ of the Duncan–Chang model with the disturbed degree of sand, in which the effects of the initial void ratio on the strength deformation property of sands are considered using a unified disturbance function based on disturbed state concept theory. Three cases were analyzed to investigate the validity of the proposed constitutive model considering disturbance. After validation, the proposed constitutive model was further incorporated into a 3D finite element framework to predict the soil deformation caused by shield construction. It was found that the simulated results agreed well with the analytical solution, indicating that the developed numerical model with proposed constitutive relationship is capable of characterizing the mechanical properties of sand under tunneling construction disturbance.

TRPM7 Mediates Neuronal Cell Death Upstream of Calcium/Calmodulin-Dependent Protein Kinase II and Calcineurin Mechanism in Neonatal Hypoxic-Ischemic Brain Injury - Ekaterina Turlova; Raymond Wong; Baofeng Xu; Feiya Li; Lida Du; Steven Habbous; F. David Horgen; Andrea Fleig; Zhong-Ping Feng; Hong-Shuo Sun (Translational Stroke Research, 2021)

Curcumin protects thymus against D-galactose-induced senescence in mice - Jie-han Li; Ting-ting Wei; Li Guo; Jia-hui Cao; Yuan-kang Feng; Shu-ning Guo; Guo-hong Liu; Yi Ding; Yu-rong Chai (Naunyn-Schmiedeberg's Archives of Pharmacology, 2021)

MiR-126-3p-Enriched Extracellular Vesicles from Hypoxia-Preconditioned VSC 4.1 Neurons Attenuate Ischaemia-Reperfusion-Induced Pain Hypersensitivity by Regulating the PIK3R2-Mediated Pathway - He Wang; Feng-Shou Chen; Zai-Li Zhang; Hong-Xu Zhou; Hong Ma; Xiao-Qian Li (Molecular Neurobiology, 2021)

What determines the climate mitigation process of China’s regional industrial sector? - Hong Zang; Miao Wang; Chao Feng (Environmental Science and Pollution Research, 2021)

Effects of lithium resource exploitation on surface water at Jiajika mine, China - Juan-Qin Gao; Yang Yu; Deng-Hong Wang; Wei Wang; Cheng-Hui Wang; Hong-Zhang Dai; Xue-Feng Hao; Kuang Cen (Environmental Monitoring and Assessment, 2021)

Risk assessment of non-point source pollution of land use system of mountainous watershed and spatially referenced regressions on watershed attributes simulation under geological environment assessment - Leijin Long; Feng He; Hong Zhang (Arabian Journal of Geosciences, 2021)

PapA , a peptidoglycan‐associated protein, interacts with OmpC and maintains cell envelope integrity - Yun‐Hao Wang; Hong‐He Chen; Zhou Huang; Xiao‐Jing Li; Nan Zhou; Chang Liu; Cheng‐Ying Jiang; De‐Feng Li; Shuang‐Jiang Liu (Environmental Microbiology, 2021)
Summary The bacterial cell envelope is critical to support and maintain cellular life. In Gram‐negative bacterial cells, the outer membrane and the peptidoglycan layer are two important parts of the cell envelope and they harbour abundant proteins. Here, we report the identification and characterization of a previously unknown p eptidoglycan‐ a ssociated p rotein, PapA, from the Gram‐negative Comamonas testosteroni . PapA bound peptidoglycan with its C‐terminal domain and interacted with the outer‐membrane porin OmpC. The PapA‐OmpC complex riveted the outer membrane and the peptidoglycan layer, and played a role in maintaining cell envelope integrity. When papA was disrupted, the mutant CNB‐1Δ papA apparently had an outer membrane partly separated from the peptidoglycan layer. Phenotypically, the mutant CNB‐1Δ papA lost chemotactic responses and had longer lag‐phase of growth, less flagellation and higher sensitivity to harsh environments. Totally, 1093 functionally unknown PapA homologues were identified from the public NR protein database and they were mainly distributed in Burkholderiales of Betaproteobacteria. Our finding provides a clue that the PapA homologous proteins might function as a rivet to maintain cell envelope integrity in those Gram‐negative bacteria.

Sesquiterpenoids and meroterpenoids from a mangrove derived fungus Diaporthe sp. SCSIO 41011 - Xiao-Wei Luo; Chun-Mei Chen; Kun-Long Li; Xiu-Ping Lin; Cheng-Hai Gao; Xue-Feng Zhou; Yong-Hong Liu (Natural Product Research, 2021)

Memory impairment of chewing-side preference mice is associated with 5-HT-BDNF signal pathway - Hua Jiang; Hong Yin; Lin Wang; Chunzhen Feng; Yang Bai; Dongzong Huang; Qiao Zhang; Hongchen Liu; Yuan Hu (Molecular and Cellular Biochemistry, 2021)

Field tests of micro screw anchor piles under different loading conditions at three soil sites - Shi-Jin Feng; Wen-Ding Fu; Hong-Xin Chen; Hong-Xing Li; Yan-Li Xie; Shao-Feng Lv; Jin Li (Bulletin of Engineering Geology and the Environment, 2021)

Artificial Neural Network-based prediction of glacial debris flows in the ParlungZangbo Basin, southeastern Tibetan Plateau, China - Wang Tang; Hai-tao Ding; Ning-sheng Chen; Shang-Chang Ma; Li-hong Liu; Kang-lin Wu; Shu-feng Tian (Journal of Mountain Science, 2021)

Changes of compound hot and dry extremes on different land surface conditions in China during 1957–2018 - Yao Feng; Wenbin Liu; Fubao Sun; Hong Wang (International Journal of Climatology, 2021)
The co‐occurrence of hot and dry extremes (compound hot and dry extreme, CHDE) has attracted much attention due to the amplified impact on wildfire occurrence, agriculture production and human health. Most existing studies have reported the spatiotemporal variations of CHDE, changes in CHDE on different land surface conditions are barely discussed. The study investigated the spatial and temporal differences of CHDE over different regions and land covers in China during 1957–2018. On average over China, both day‐ and night‐time CHDEs have increased with a more rapid (2.6 times faster) and significant ( p p

Quantitative Determination of Trace Lipopeptide Using HPLC through Double Carboxyls Labelling - Shi-Zhong Yang; Hong-Zhi Quan; Jin-Feng Liu; Hong-Ze Gang; Bo-Zhong Mu (International Journal of Peptide Research and Therapeutics, 2020)

The Complete Genome Sequence of a Bacterial Strain with High Alkalic Xylanase Activity Isolated from the Sludge Near a Papermill - Si Chen; Hao Feng; Xin Li; Hong-jun Chao; Jing Wu; Jun Liu; Wen-jun Zhu; Da-zhong Yan (Current Microbiology, 2020)

Without insight accompanied with deteriorated brain functional alterations in healthy individuals with auditory verbal hallucinations: a pilot study - Chuanjun Zhuo; Feng Ji; Xiaodong Lin; Hongjun Tian; Lina Wang; Sha Liu; Hong Sang; Wenqiang Wang; Chunmian Chen (Brain Imaging and Behavior, 2020)
Few studies have reported on brain functional differences between healthy individuals with auditory verbal hallucinations (Hi-AVH) with and without insight, so we designed a study to address this knowledge gap. We enrolled 12 Hi-AVH with insight, 15 Hi-AVH without insight, and 15 AVH-free controls (Healthy controls). Global functional connectivity density (gFCD) mapping was used to estimate brain networks. We found that the most common alterations in both Hi-AVH groups were increased gFCD in superior parietal lobule and superior temporal gyrus. We also found that distinct brain functional patterns of Hi-AVH without insight comprised lower gFCD in the frontal lobe oculomotor area, dorsolateral prefrontal cortex, supramarginal gyrus, primary auditory cortex, sensorimotor cortex, ventral anterior, and posterior cingulate Our pilot findings support the hypothesis that abnormal reciprocal action in the circuits for processing perception, memory, language, and attentional control may be pathological features of auditory verbal hallucinations.

3D prestack reverse time migration of ground penetrating radar data based on the normalized correlation imaging condition - Hong-Hua Wang; Jun-bo Gong; Zhi Zhang; Bin Xiong; Yu-zeng Lv; De-shan Feng; Qian-wei Dai (Applied Geophysics, 2020)

Influence of complex topography on magnetotelluric-observed data using three-dimensional numerical simulation: A case from Guangxi area, China - Xiong Bin; Luo Tian-Ya; Chen Long-Wei; Dai Shi-Kun; Xu Zhi-Feng; Li Chang-Wei; Ding Yan-Li; Wang Hong-Hua; Li Jing-He (Applied Geophysics, 2020)

A non-structural protein encoded by Rice Dwarf Virus targets to the nucleus and chloroplast and inhibits local RNA silencing - Feng Gao; Shanshan Zhao; Shuzhen Men; Zhensheng Kang; Jian Hong; Chunhong Wei; Wei Hong; Yi Li (Science China Life Sciences, 2020)

Impact of Chronic Stress on Attention Control: Evidence from Behavioral and Event-Related Potential Analyses - Qingjin Liu; Yong Liu; Xuechen Leng; Jinfeng Han; Feng Xia; Hong Chen (Neuroscience Bulletin, 2020)

Two new species and a new record of Nigrograna (Nigrogranaceae, Pleosporales) from China and Thailand - Jin-Feng Zhang; Jian-Kui (Jack) Liu; Kasun M. Thambugala; Jing Yang; Ze-Hong Meng; Zuo-Yi Liu (Mycological Progress, 2020)

Diagnostic value of optic disc retinal nerve fiber layer thickness for diabetic peripheral neuropathy - Xiao-hong Wu; Jing-wen Fang; Yin-qiong Huang; Xue-feng Bai; Yong Zhuang; Xiao-yu Chen; Xia-hong Lin (Journal of Zhejiang University-SCIENCE B, 2020)

Nonylphenol occurrence, distribution, toxicity and analytical methods in freshwater - Yajun Hong; Chenglian Feng; Zhenfei Yan; Ying Wang; Daqing Liu; Wei Liao; Yingchen Bai (Environmental Chemistry Letters, 2020)

Characterization of a Protease Hyper-Productive Mutant of Bacillus pumilus by Comparative Genomic and Transcriptomic Analysis - Yong-Cheng Liu; Lin-Li Han; Tian-Yu Chen; Yan-Bing Lu; Hong Feng (Current Microbiology, 2020)

Prevalence of Clonorchis sinensis infection in fish in South‐East Asia: A systematic review and meta‐analysis - Ying Zhang; Qing‐Long Gong; Qing‐Bo Lv; Yang‐Yuan Qiu; Yan‐Chun Wang; Hong‐Yu Qiu; Xin‐Rui Guo; Jun‐Feng Gao; Qiao‐Cheng Chang; Chun‐Ren Wang (Journal of Fish Diseases, 2020)
Clonorchis sinensis , an important fish‐borne zoonotic trematode, is widely distributed in South‐East Asia, especially in China. Infections from human and animal reservoir hosts occur due to the consumption of raw or undercooked fish with C. sinensis metacercariae. This study aimed to evaluate the prevalence of C. sinensis metacercariae in fish in South‐East Asia via systematic review and meta‐analysis. We searched PubMed, ScienceDirect, China National Knowledge Infrastructure, Wanfang and Chongqing VIP databases for studies published between 1976 and 2020 that are related to the prevalence of C. sinensis metacercariae in fish. Studies were screened with keywords based on inclusion and exclusion criteria. Seventy‐one eligible articles were identified, covering three countries: China, Korea and Vietnam. The pooled prevalence of C. sinensis metacercariae in fish from South‐East Asia was 30.5%, with 35.1% in China, 29.7% in Korea and 8.4% in Vietnam. In subgroup analyses of climate, season, water source and publication date, the highest prevalence was identified in the Dwb climate type (43.3%), summer (70.2%), river (34.5%) and pre‐2001 publications (38.9%), respectively. In comparison, the lowest prevalence was found in the Dfa climate type (14.5%), winter (19.5%), lake (8.0%) and post‐2001 publications (23.8%). Meta‐regression results indicated that country ( p = .009), the published time ( p = .035) and water source subgroups ( p = .003) may be the source of heterogeneity. Overall, our study indicates that a high prevalence of C. sinensis infections occurs in fish in China, Korea and Vietnam, illuminating a significant public health concern in these countries.

Silencing of Long Non-coding RNA GAS5 Suppresses Neuron Cell Apoptosis and Nerve Injury in Ischemic Stroke Through Inhibiting DNMT3B-Dependent MAP4K4 Methylation - Yiming Deng; Duanduan Chen; Feng Gao; Hong Lv; Guojun Zhang; Xuan Sun; Lian Liu; Dapeng Mo; Ning Ma; Ligang Song; Xiaochuan Huo; Tianyi Yan; et al. (Translational Stroke Research, 2020)

Creation of fertility-restored materials for Ogura CMS in Brassica oleracea by introducing Rfo gene from Brassica napus via an allotriploid strategy - Hai-long Yu; Zhi-yuan Li; Wen-jing Ren; Feng-qing Han; Li-mei Yang; Mu Zhuang; Hong-hao Lv; Yu-mei Liu; Zhi-yuan Fang; Yang-yong Zhang (Theoretical and Applied Genetics, 2020)
Key message Ogura CMS fertility-restored materials, with 18 chromosomes, normal seed setting, stable fertility and closer genetic background to the parent Chinese kale, were successfully developed in B. oleracea via a triploid strategy for the first time. Abstract Ogura cytoplasmic male sterility (CMS) is the most widely used sterile type in seed production for commercial hybrids of Brassica oleracea vegetables. However, the natural Ogura CMS restorer line has not been found in B. oleracea crops. In this study, the triploid strategy was used with the aim to create euploid B. oleracea progenies with the Rfo gene. The allotriploid AAC hybrid YL2 was used as a male parent to backcross with Ogura CMS Chinese kale. After successive backcrosses, the BC 2 Rfo -positive individual 16CMSF2-11 and its BC 3 progenies, with 18 chromosomes, were developed, which were morphologically identical to the parent Chinese kale. Compared with F 1 and BC 1 plants, it showed stable fertility performance, and regular meiosis behavior and could produce seeds normally under natural pollination. The genomic composition analysis of Rfo -positive progenies by using molecular markers showed that more than 87% of the C-genome components of BC 3 Rfo -progenies recovered to the parent Chinese kale, while most or all of the A n -genome segments were lost in 16CMSF2-11 and its progenies. The results suggested that the genetic background of Rfo -positive individuals was closer to that of the parent Chinese kale along with backcrossing. Hereof, the Ogura CMS fertility-restored materials of Chinese kale were successfully created via triploid strategy for the first time, providing a bridge for utilizing the Ogura CMS B. oleracea germplasm in the future. Moreover, our study indicates that the triploid strategy is effective for transferring genes from B. napus into B. oleracea .

Recent developments in regenerative ophthalmology - Ye Shen; He Shen; Dongyu Guo; Xinghuai Sun; Yuan Sun; Nan Hong; Xiawei Wang; Chen Xie; Yuan Zhao; Qin He; Le Jin; Yingying Wen; et al. (Science China Life Sciences, 2020)

Liquiritin inhibits proliferation and induces apoptosis in HepG2 hepatocellular carcinoma cells via the ROS-mediated MAPK/AKT/NF-κB signaling pathway - Jia-Ru Wang; Tian-Zhu Li; Cheng Wang; Shu-Mei Li; Ying-Hua Luo; Xian-Ji Piao; Yu-Chao Feng; Yi Zhang; Wan-Ting Xu; Yu Zhang; Tong Zhang; Shi-Nong Wang; et al. (Naunyn-Schmiedeberg's Archives of Pharmacology, 2020)

Transcriptome analysis of rice leaves in response to Rhizoctonia solani infection and reveals a novel regulatory mechanism - De Peng Yuan; Xiao Feng Xu; Woo-Jong Hong; Si Ting Wang; Xin Tong Jia; Yang Liu; Shuang Li; Zhi Min Li; Qian Sun; Qiong Mei; Shuai Li; Ki-Hong Jung; et al. (Plant Biotechnology Reports, 2020)

Epidemiological and phylogenetic analysis of canine kobuviruses in Tangshan, China - Zhaoyang Wang; Yajun Jiang; Xueting Liu; Weidong Lin; Qianqian Feng; Ting Xin; Xiaoyu Guo; Shaohua Hou; Hongfei Zhu; Hong Jia (Archives of Virology, 2020)

Effects of dietary Lactobacillus plantarum C20015 on growth, immunity, and disease resistance in koi carp - Hai-peng Zhang; Wen-long Dong; Long Chen; Yi-ming Wang; Inam Muhammad; An-qi Ju; Xiao-feng Shan; Hong-xia Ma; Ling-cong Kong (Aquaculture International, 2020)

Characterization of a Cu2+, SDS, alcohol and glucose tolerant GH1 β-glucosidase from Bacillus sp. CGMCC 1.16541 - Yi-Rui Yin; Peng Sang; Feng-Li Yang; Tao Li; Run-Feng Yang; Hong-Yan Liu; Zong-Long Luo; Wen-Jun Li; Li-Quan Yang (Antonie van Leeuwenhoek, 2020)

Archaeobotanical evidence reveals the human–environment interactions during the 9th–13th centuries at Turpan, Xinjiang on the ancient Silk Road - Yi-Feng Yao; Xia Wang; Wu Guo; Hong-En Jiang; Min Li; David K. Ferguson; Yu-Fei Wang; Cheng-Sen Li (Vegetation History and Archaeobotany, 2020)

Macrophage–NLRP3 Inflammasome Activation Exacerbates Cardiac Dysfunction after Ischemic Stroke in a Mouse Model of Diabetes - Hong-Bin Lin; Guan-Shan Wei; Feng-Xian Li; Wen-Jing Guo; Pu Hong; Ya-Qian Weng; Qian-Qian Zhang; Shi-Yuan Xu; Wen-Bin Liang; Zhi-Jian You; Hong-Fei Zhang (Neuroscience Bulletin, 2020)

Heat-air-moisture coupled model for radon migration in a porous media - Yu Cui; Shengyang Feng; Puxin Chen; Yongjun Ye; Yurong Wu; Ce Li; Rong Yang; Hong Wang (Environmental Science and Pollution Research, 2020)

Lacustrine record from the eastern Tibetan Plateau associated with Asian summer monsoon changes over the past ~ 6 ka and its links with solar and ENSO activity - Guodong Ming; Weijian Zhou; Peng Cheng; Hong Wang; Feng Xian; Yunchong Fu; Shugang Wu; Hua Du (Climate Dynamics, 2020)

Interferon-α2b spray inhalation did not shorten virus shedding time of SARS-CoV-2 in hospitalized patients: a preliminary matched case-control study - Shao-rui Hao; Ren Yan; Shan-yan Zhang; Jiang-shan Lian; Huan Cai; Xiao-li Zhang; Lin Zheng; Hong-yu Jia; Jian-hua Hu; Guo-dong Yu; Jue-qing Gu; Chan-yuan Ye; et al. (Journal of Zhejiang University-SCIENCE B, 2020)

First record of field dodder (Cuscuta campestris) parasitizing invasive buffalobur (Solanum rostratum) - Wei-Bin Wang; Fan-Fan Gao; Mei-Ni Shao; Ming-Chao Liu; Hong-Feng Zhai; Bo Qu; Yu-Long Feng (Journal of Plant Pathology, 2020)

Two novel pleiotropic loci associated with osteoporosis and abdominal obesity - Lu Liu; Xiao-Lin Yang; Hong Zhang; Zi-Jia Zhang; Xin-Tong Wei; Gui-Juan Feng; Ju Liu; Hui-Ping Peng; Rong Hai; Hui Shen; Qing Tian; Hong-Wen Deng; et al. (Human Genetics, 2020)

Brief report of the first cured 2019-nCoV pneumonia patient in West China Hospital - En-Qiang Chen; Li-Chun Wang; Guang-Min Tang; Yao Yang; Min-Jin Wang; Rong Deng; Fang Chen; Meng-Lan Wang; Ya-Chao Tao; Ping Feng; Hong Tang (European Journal of Clinical Microbiology & Infectious Diseases, 2020)

Isolation and Identification of Endophytic Fungi in Kernels of Coix lachrymal-jobi L. Cultivars - Guan-rong Li; Bao-hong Cao; Wei Liu; Rui-hua Ren; Jie Feng; Da-jin Lv (Current Microbiology, 2020)

Analysis of main pathogenic bacteria and drug sensitivity in patients with chronic suppurative otitis media and middle ear cholesteatoma in China - Feng Xu; Weili Kong; Jiaojiao Peng; Hailing Gu; Hong Zheng (Biotechnology Letters, 2020)

High throughput solid-phase screening of bacteria with cyclic amino alcohol deamination activity for enantioselective synthesis of chiral cyclic β-amino alcohols - Ya-Wen Chang; Jian-Dong Zhang; Xiao-Xiao Yang; Jing Li; Li-Li Gao; Shuang-Ping Huang; Xing-Mei Guo; Cao-Feng Zhang; Hong-Hong Chang; Jian-He Xu (Biotechnology Letters, 2020)

Ecological impact assessment method of highways in Tibetan Plateau: A Case study of Gonghe-Yushu Expressway - Hong-zhi Yang; Zhen-feng Wang; Qing-miao Dai (Journal of Mountain Science, 2020)

In Vitro Evaluation of the Antibacterial Properties of Tea Tree Oil on Planktonic and Biofilm-Forming Streptococcus mutans - Yu-Meng Song; Hong-Yan Zhou; Ye Wu; Jue Wang; Qian Liu; Yu-Feng Mei (AAPS PharmSciTech, 2020)

Influence of Loading and Unloading Stress Paths on the Deformation and Failure Features of Jinping Marble Under True Triaxial Compression - Xia-Ting Feng; Hong Xu; Chengxiang Yang; Xiwei Zhang; Yaohui Gao (Rock Mechanics and Rock Engineering, 2020)

A review of progress in coupled ocean-atmosphere model developments for ENSO studies in China - Rong-Hua Zhang; Yongqiang Yu; Zhenya Song; Hong-Li Ren; Youmin Tang; Fangli Qiao; Tongwen Wu; Chuan Gao; Junya Hu; Feng Tian; Yuchao Zhu; Lin Chen; et al. (Journal of Oceanology and Limnology, 2020)

Molecular characterization of a novel mycovirus infecting the phytopathogenic fungus Botryosphaeria dothidea - Mengmeng Yang; Xiaoqi Zhou; Lifeng Zhai; Feng Xiao; Ni Hong; Guoping Wang (Archives of Virology, 2020)

Streptomyces taklimakanensis sp. nov., an actinomycete isolated from the Taklimakan desert - Lin-Lin Yuan; Li-Li Zhang; Xiao-Xia Luo; Zhan-Feng Xia; Bei-Bei Sun; Hong Zeng (Antonie van Leeuwenhoek, 2020)

The Fundamental and Functional Property Differences Between HPMC and PVP Co-Processed Herbal Particles Prepared by Fluid Bed Coating - Zhe Li; Fei Wu; YanLong Hong; Lan Shen; Xiao Lin; Yi Feng (AAPS PharmSciTech, 2020)

Enhanced Antitumor Efficacy of Curcumin-Loaded PLGA Nanoparticles Coated with Unique Fungal Hydrophobin - Lu Sun; Hui Xu; Jing-hua Xu; Shao-ning Wang; Jun-wei Wang; Hong-feng Zhang; Wei-ru Jia; Lin-sen Li (AAPS PharmSciTech, 2020)

New 2-(2-phenylethyl)chromone derivatives from agarwood and their inhibitory effects on tumor cells - Yang-Yang Liu; De-Li Chen; Zhang-Xin Yu; Wang Can-Hong; Jian Feng; Yu Meng; Jian-He Wei (Natural Product Research, 2020)

Long interpregnancy interval and adverse perinatal outcomes: A retrospective cohort study - Jing Lin; Han Liu; Dan-Dan Wu; Hong-Tao Hu; Hui-Hui Wang; Cheng-Liang Zhou; Xin-Mei Liu; Xiao-Jun Chen; Jian-Zhong Sheng; He-Feng Huang (Science China Life Sciences, 2020)

The Family of Peanut Fatty Acid Desaturase Genes and a Functional Analysis of Four ω-3 AhFAD3 Members - Zhenying Peng; Jian Ruan; Haiying Tian; Lei Shan; Jingjing Meng; Feng Guo; Zhimeng Zhang; Hong Ding; Shubo Wan; Xinguo Li (Plant Molecular Biology Reporter, 2020)
The synthesis of α-linolenic acid (ALA) requires the activity of ω-3 fatty acid desaturases (ω-3 FADs). The quality of peanut oil would be much improved if the content of ALA could be increased. A scan of the peanut genome revealed that it harbored 36 FAD genes, mapping to 16 of the species’ 20 chromosomes. A phylogenetic analysis concluded that these genes belonged to six sub-families, namely stearoyl-acyl-acyl carrier protein desaturases ( SAD ), FAD2 , FAD3 , FAD4/5 , FAD6 and FAD7/8 . Of these, FAD3 and FAD7/8 encoded ω-3 FADs, while genes belonging to the other four sub-families encoded ω-6 FADs. Based on RNA-Seq data, each of the 36 FAD genes was shown to be transcribed in non-stressed plants, but there was variation between them with respect to which organs they were transcribed in. Four ω-3 AhFAD3 genes were functionally characterized; when expressed in Arabidopsis thaliana protoplasts, each was localized mainly in the endoplasmic reticulum, while within peanut, the genes were more strongly transcribed in the developing seed than in either the root or the leaf. When constitutively expressed in Arabidopsis thaliana , both the total fatty acid content of the seed and the relative contribution of ALA were increased. The transgenic seedlings also exhibited an improved level of survival when challenged by salinity stress.

Seismic hazard assessment for mainland China based on spatially smoothed seismicity - C. Feng; T. J. Liu; H. P. Hong (Journal of Seismology, 2020)

Field cage assessment of feeding damage by Halyomorpha halys on kiwifruit orchards in China - Ju-Hong Chen; Gonzalo A. Avila; Feng Zhang; Lindy F. Guo; Manoharie Sandanayaka; Qian-Qian Mi; Shu-Sen Shi; Jin-Ping Zhang (Journal of Pest Science, 2020)

Finding Community Modules for Brain Networks Combined Uniform Design with Fruit Fly Optimization Algorithm - Jie Zhang; Junhong Feng; Yifang Yang; Jian-Hong Wang (Interdisciplinary Sciences: Computational Life Sciences, 2020)

Correction to: Simulated microgravity significantly altered metabolism in epidermal stem cells - Bin-Bin Li; Zheng-Yang Chen; Nan Jiang; Song Guo; Jia-Qi Yang; Shao-Bin Chai; Hong-Feng Yan; Pei-Ming Sun; Gang Hu; Tao Zhang; Bing-Xin Xu; Hong-Wei Sun; et al. (In Vitro Cellular & Developmental Biology - Animal, 2020)

Effects of biochar content on gas diffusion coefficient of soil with different compactness and air contents - Fu Quan Chen; Neng Kai Zhao; Song Feng; Hong Wei Liu; Yu Chuan Liu (Environmental Science and Pollution Research, 2020)

Effect of probiotic administration on gut microbiota and depressive behaviors in mice - Quan Feng Liu; Hong-Man Kim; Sanghyun Lim; Myung-Jun Chung; Chi-Yeon Lim; Byung-Soo Koo; Seok-Seong Kang (DARU Journal of Pharmaceutical Sciences, 2020)

Molecular evolution of GII.P17-GII.17 norovirus associated with sporadic acute gastroenteritis cases during 2013–2018 in Zhoushan Islands, China - Can Chen; Bing Wu; Hui Zhang; Ke-Feng Li; Rong Liu; Hong-Ling Wang; Jian-Bo Yan (Virus Genes, 2020)

Leaf size of woody dicots predicts ecosystem primary productivity - Yaoqi Li; Peter B. Reich; Bernhard Schmid; Nawal Shrestha; Xiao Feng; Tong Lyu; Brian S. Maitner; Xiaoting Xu; Yichao Li; Dongting Zou; Zheng‐Hong Tan; Xiangyan Su; et al. (Ecology Letters, 2020)
A key challenge in ecology is to understand the relationships between organismal traits and ecosystem processes. Here, with a novel dataset of leaf length and width for 10 480 woody dicots in China and 2374 in North America, we show that the variation in community mean leaf size is highly correlated with the variation in climate and ecosystem primary productivity, independent of plant life form. These relationships likely reflect how natural selection modifies leaf size across varying climates in conjunction with how climate influences canopy total leaf area. We find that the leaf size‒primary productivity functions based on the Chinese dataset can predict productivity in North America and vice‐versa. In addition to advancing understanding of the relationship between a climate‐driven trait and ecosystem functioning, our findings suggest that leaf size can also be a promising tool in palaeoecology for scaling from fossil leaves to palaeo‐primary productivity of woody ecosystems.

Two new aromatic polyketides from a deep-sea fungus Penicillium sp. SCSIO 06720 - Cui Guo; Xiu-Ping Lin; Sheng-Rong Liao; Bin Yang; Xue-Feng Zhou; Xian-Wen Yang; Xin-Peng Tian; Jun-Feng Wang; Yong-Hong Liu (Natural Product Research, 2020)

Comparison of epidemiological and clinical characteristics of COVID-19 patients with and without Wuhan exposure - Jiang-shan Lian; Huan Cai; Shao-rui Hao; Xi Jin; Xiao-li Zhang; Lin Zheng; Hong-yu Jia; Jian-hua Hu; Shan-yan Zhang; Guo-dong Yu; Jue-qing Gu; Chan-yuan Ye; et al. (Journal of Zhejiang University-SCIENCE B, 2020)

First report of actinidia virus A and B infecting kiwifruit in Jiangxi province in China - Man Fei Zou; Ming Feng Yan; Ying Zhou; Yuan Xiu Wang; Gui Hong Xiong; Jun Xi Jiang (Journal of Plant Pathology, 2020)

Effect of three Napier grass varieties on phytoextraction of Cd- and Zn-contaminated cultivated soil under mowing and their safe utilization - Wen-Jun Yang; Jiao-Feng Gu; Hang Zhou; Fang Huang; Teng-Yue Yuan; Jing-Yi Zhang; Shi-Long Wang; Zhi-Guang Sun; Hong-Wei Yi; Bo-Han Liao (Environmental Science and Pollution Research, 2020)

Immunogenicity noninferiority study of 2 doses and 3 doses of an Escherichia coli-produced HPV bivalent vaccine in girls vs. 3 doses in young women - Yue-Mei Hu; Meng Guo; Chang-Gui Li; Kai Chu; Wen-Gang He; Jing Zhang; Jian-Xiang Gu; Juan Li; Hui Zhao; Xiang-Hong Wu; BiZhen Lin; Zhi-Jie Lin; et al. (Science China Life Sciences, 2020)

The Potential Role of PKA/CREB Signaling Pathway Concerned with Gastrodin Administration on Methamphetamine-Induced Conditioned Place Preference Rats and SH-SY5Y Cell Line - Gen-Meng Yang; Lu Li; Feng-Lin Xue; Chen-Li Ma; Xiao-Feng Zeng; Yong-Na Zhao; Dong-Xian Zhang; Yang Yu; Qian-Wen Yan; Yi-Qing Zhou; Shi-Jun Hong; Li-Hua Li (Neurotoxicity Research, 2020)

Abnormal differentiation of regulatory T cells and Th17 cells induced by perinatal bisphenol A exposure in female offspring mice - You-dan Dong; Liang Gao; Feng-juan Wu; Ren Lin; Yuan Meng; Li-hong Jia; Xiao-fei Wang (Molecular & Cellular Toxicology, 2020)

Gypenosides Prevent H2O2-Induced Retinal Ganglion Cell Apoptosis by Concurrently Suppressing the Neuronal Oxidative Stress and Inflammatory Response - Hong-Kan Zhang; Yuan Ye; Kai-Jun Li; Zhen-ni Zhao; Jian-Feng He (Journal of Molecular Neuroscience, 2020)
Our previous study demonstrated that gypenosides (Gp) exert protective effects on retinal nerve fibers and axons in a mouse model of experimental autoimmune optic neuritis. However, the therapeutic mechanisms remain unclear. Thus, in this study, a model of oxidative damage in retinal ganglion cells (RGCs) was established to investigate the protective effect of Gp, and its possible influence on oxidative stress in RGCs. Treatment of cells with H 2 O 2 induced RGC injury owing to the generation of intracellular reactive oxygen species (ROS). In addition, the activities of antioxidative enzymes decreased and the expression of inflammatory factors increased, resulting in an increase in cellular apoptosis. Gp helped RGCs to become resistant to oxidation damage by directly reducing the amount of ROS in cells and exerting protective effects against H 2 O 2 -induced apoptosis. Treatment with Gp also reduced the generation of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), and increased nuclear respiratory factor 2 (Nrf-2) levels so as to increase the levels of heme oxygenase-1 (HO-1) and glutathione peroxidase 1/2 (Gpx1/2), which can enhance antioxidation in RGCs. In conclusion, our data indicate that neuroprotection by Gp involves its antioxidation and anti-inflammation effects. Gp prevents apoptosis through a mitochondrial apoptotic pathway. This finding might provide novel insights into understanding the mechanism of the neuroprotective effects of gypenosides in the treatment of optic neuritis.

The diagnostic value of serum DSA-TRF in hepatocellular carcinoma - Wenqian Guan; Zhiyuan Gao; Chenjun Huang; Meng Fang; Huijuan Feng; Shipeng Chen; Mengmeng Wang; Jun Zhou; Song Hong; Chunfang Gao (Glycoconjugate Journal, 2020)

Litorilituus lipolyticus sp. nov., isolated from intertidal sand of the Yellow Sea in China, and emended description of Colwellia asteriadis - Ang Liu; Yan-Jiao Zhang; Qing-Jie Xue; Hui Wang; Yuan-Yuan Yang; Feng Du; Long-Yu Zhao; Hong-Hua Zhang; Yun-Qing Li; Xiu-Zhen Li (Antonie van Leeuwenhoek, 2020)

Tectonic affinity of the Khanka Massif in the easternmost Central Asian Orogenic Belt: evidence from detrital zircon geochronology of Permian sedimentary rocks - Kai-Chen Xing; Feng Wang; Wen-Liang Xu; Fu-Hong Gao (International Geology Review, 2020)

Engineering of glycerol utilization in Pseudomonas chlororaphis GP72 for enhancing phenazine-1-carboxylic acid production - Chen Song; Sheng-Jie Yue; Wen-Hui Liu; Yi-Fan Zheng; Cheng-Hao Zhang; Tong-Tong Feng; Hong-Bo Hu; Wei Wang; Xue-Hong Zhang (World Journal of Microbiology and Biotechnology, 2020)

Sources and ore-forming fluid pathways of carbonate-hosted Pb–Zn deposits in Southwest China: implications of Pb–Zn–S–Cd isotopic compositions - Chong Xu; Hong Zhong; Rui-Zhong Hu; Han-Jie Wen; Wei-Guang Zhu; Zhong-Jie Bai; Hai-Feng Fan; Fang-Fang Li; Ting Zhou (Mineralium Deposita, 2020)

Simulated microgravity significantly altered metabolism in epidermal stem cells - Bin-Bin Li; Zheng-Yang Chen; Nan Jiang; Song Guo; Jia-Qi Yang; Shao-Bin Chai; Hong-Feng Yan; Pei-Ming Sun; Gang Hu; Tao Zhang; Bing-Xin Xu; Hong-Wei Sun; et al. (In Vitro Cellular & Developmental Biology - Animal, 2020)
Simulated microgravity can significantly affect various cell types and multiple systems of the human body, such as cardiovascular system, skeletal muscle system, and immune system, and is known to cause anemia and loss of electrolyte and fluids. Epidermal stem cells (EpSCs) were cultured in a rotary cell culture system (RCCS) bioreactor to simulate microgravity. The metabolites of EpSCs were identified by liquid chromatography-mass spectrometry (LC-MS). Compared with normal gravity (NG) group, a total of 57 different metabolites of EpSCs were identified ( P < 0.05, VIP > 1), including lipids and lipid-like molecules (51 molecules), amino acids (5 molecules), nucleosides, nucleotides, and analogues (1 molecule). According to the partial least squares discriminant analysis (PLS-DA) score plot, a VIP > 1 and P < 0.05 were obtained for the 57 different metabolites, of which 23 molecules were significantly downregulated and 34 were significantly upregulated in simulated microgravity (SMG) group. These results showed that SMG has a significant impact on different pathways, and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis indicated that multiple pathways were involved, mainly the amino acid metabolism pathway, lipid metabolism pathway, membrane transport pathway, and cell growth and death pathways. Thus, the metabolic profile of EpSCs was changed under SMG. Exploring the metabolic profile of EpSCs would be helpful to further understand the growth characteristics of EpSCs under SMG, which will provide a new approach to explore the metabolomics mechanism of stress injury and repair trauma under SMG.

Chemical content and source apportionment of 36 heavy metal analysis and health risk assessment in aerosol of Beijing - Limeng Cui; Zhuona Wu; Peng Han; Yasuyuki Taira; Huan Wang; Qinghua Meng; Zechen Feng; Shuguang Zhai; Jun Yu; Weijie Zhu; Yuxia Kong; Hongfang Wang; et al. (Environmental Science and Pollution Research, 2020)

No evidence of greater biomass allocation to stolons at moderate resource levels in a floating plant - Chao Si; Wei Xue; Jing Lin; Jian-Feng Zhang; Meng-Meng Hong; Yi-Yue Wang; Liu-Fang Zhang; Fei-Hai Yu (Aquatic Ecology, 2020)

Phosphorus-fertilisation has differential effects on leaf growth and photosynthetic capacity of Arachis hypogaea L. - Qingwen Shi; Jiayin Pang; Jean Wan Hong Yong; Chunming Bai; Caio Guilherme Pereira; Qiaobo Song; Di Wu; Qiping Dong; Xin Cheng; Feng Wang; Junlin Zheng; Yifei Liu; et al. (Plant and Soil, 2020)

Chemical Stimulation of Renal Tissue Induces Sympathetic Activation and a Pressor Response via the Paraventricular Nucleus in Rats - Chao Ye; Yun Qiu; Feng Zhang; Ai-Dong Chen; Hong Zhou; Jue-Jin Wang; Qi Chen; Yue-Hua Li; Yu-Ming Kang; Guo-Qing Zhu (Neuroscience Bulletin, 2020)

Geochronological and sulfur isotopic evidence for the genesis of the post-magmatic, deeply sourced, and anomalously gold-rich Daliuhang orogenic deposit, Jiaodong, China - Kai Feng; Hong-Rui Fan; David I. Groves; Kui-Feng Yang; Fang-Fang Hu; Xuan Liu; Ya-Chun Cai (Mineralium Deposita, 2020)

Effectiveness analysis of the prediction of regional debris flow susceptibility in post-earthquake and drought site - Ning-sheng Chen; Yong Zhang; Shu-feng Tian; Ming-feng Deng; Tao Wang; Li-hong Liu; Mei Liu; Gui-sheng Hu (Journal of Mountain Science, 2020)

The false smut pathogen Ustilaginoidea virens requires rice stamens for false smut ball formation - Jing Fan; Jie Liu; Zhi‐You Gong; Pei‐Zhou Xu; Xiao‐Hong Hu; Jin‐Long Wu; Guo‐Bang Li; Juan Yang; Yu‐Qiu Wang; Yu‐Feng Zhou; Shuang‐Cheng Li; Li Wang; et al. (Environmental Microbiology, 2020)
Summary Rice false smut has emerged as a serious grain disease in rice production worldwide. The disease is characterized by the transformation of individual rice florets into false smut balls, which is caused by the fungal pathogen Ustilaginoidea virens . To date, little is known about the host factors required for false smut ball formation by U . virens . In this study, we identified histological determinants for the formation of false smut balls by inoculating U . virens into rice floral mutants defective with respect to individual floral parts. The results showed that U . virens could form mature false smut balls in rice floral mutants with defective pistils, but failed to develop false smut balls in the superwoman mutant lacking stamens, identifying that U . virens requires rice stamens to complete its infection cycle. Comparative transcriptome analysis indicated a list of candidate host genes that may facilitate nutrient acquisition by U . virens from the rice stamens, such as SWEET11 , SWEET14 and SUT5 , and genes involved in the biosynthesis of trehalose and raffinose family sugars. These data pinpoint rice stamens as the key target organ of U . virens infection and provide a valuable starting point for dissecting the molecular mechanism of false smut ball formation.

Photoproduction of nitric oxide in seawater - Ye Tian; Gui-Peng Yang; Chun-Ying Liu; Pei-Feng Li; Hong-Tao Chen; Hermann W. Bange (Ocean Science, 2020)
Nitric oxide (NO) is a short-lived intermediate of the oceanic nitrogen cycle. However, our knowledge about its production and consumption pathways in oceanic environments is rudimentary. In order to decipher the major factors affecting NO photochemical production, we irradiated several artificial seawater samples as well as 31 natural surface seawater samples in laboratory experiments. The seawater samples were collected during a cruise to the western tropical North Pacific Ocean (WTNP, a N–S section from 36 to 2∘ N along 146 to 143∘ E with 6 and 12 stations, respectively, and a W–E section from 137 to 161∘ E along the Equator with 13 stations) from November 2015 to January 2016. NO photoproduction rates from dissolved nitrite in artificial seawater showed increasing trends with decreasing pH, increasing temperature, and increasing salinity. In contrast, NO photoproduction rates (average: 0.5±0.2×10-12 mol L−1 s−1) in the natural seawater samples from the WTNP did not show any correlations with pH, water temperature, salinity, or dissolved inorganic nitrite concentrations. The flux induced by NO photoproduction in the WTNP (average: 13×10-12 mol m−2 s−1) was significantly larger than the NO air–sea flux density (average: 1.8×10-12 mol m−2 s−1), indicating a further NO loss process in the surface layer.

Relationship Between Seismic Electric Signals and Tectonics Derived from Dense Geoelectric Observations in Taiwan - Feng Jiang; Xiaobin Chen; Chien-Chih Chen; Hong-jia Chen (Pure and Applied Geophysics, 2020)

Characterization and fine mapping of Arabidopsis RLL3, a locus required for DNA demethylation pathway - Wei Miao; Jie Dai; Yumei La; Chong Lu; Jianzhen Zhang; Xinyue Hong; Shaoxia Zhou; Qianqian Wang; Xiangyu Wang; Qi Rui; Feng Tan; Honggui La (Molecular Genetics and Genomics, 2020)

Tumor promoting effects of glucagon receptor: a promising biomarker of papillary thyroid carcinoma via regulating EMT and P38/ERK pathways - Hong-Chun Jiang; Xiang-Ru Chen; Hai-Feng Sun; Yuan-Wen Nie (Human Cell, 2020)

Wave and current-induced dynamic response in a multilayered poroelastic seabed - Hui-Feng Qi; Zhang-Long Chen; Yi-Cheng Li; Shi-Jin Feng; Hong-Xin Chen (Bulletin of Engineering Geology and the Environment, 2020)

Finger Tapping Task Activation vs. TMS Hotspot: Different Locations and Networks - Jue Wang; Hai-Jiang Meng; Gong-Jun Ji; Ying Jing; Hong-Xiao Wang; Xin-Ping Deng; Zi-Jian Feng; Na Zhao; Yu-Feng Zang; Jian Zhang (Brain Topography, 2020)
Both functional magnetic resonance imaging (fMRI) and transcranial magnetic stimulation (TMS) have been used to non-invasively localize the human motor functional area. These locations can be clinically used as stimulation target of TMS treatment. However, it has been reported that the finger tapping fMRI activation and TMS hotspot were not well-overlapped. The aim of the current study was to measure the distance between the finger tapping fMRI activation and the TMS hotspot, and more importantly, to compare the network difference by using resting-state fMRI. Thirty healthy participants underwent resting-state fMRI, task fMRI, and then TMS hotspot localization. We found significant difference of locations between finger tapping fMRI activation and TMS hotspot. Specifically, the finger tapping fMRI activation was more lateral than the TMS hotspot in the premotor area. The fMRI activation peak and TMS hotspot were taken as seeds for resting-state functional connectivity analyses. Compared with TMS hotspot, finger tapping fMRI activation peak showed more intensive functional connectivity with, e.g., the bilateral premotor, insula, putamen, and right globus pallidus. The findings more intensive networks of finger tapping activation than TMS hotspot suggest that TMS treatment targeting on the fMRI activation area might result in more remote effects and would be more helpful for TMS treatment on movement disorders.

Anti-bacterial chromones from cultures of the endophytic fungus Bipolaris eleusines - Juan He; Zheng-Hui Li; Hong-Lian Ai; Tao Feng; Ji-Kai Liu (Natural Product Research, 2019)

Study of Recellularized Human Acellular Arterial Matrix Repairs Porcine Biliary Segmental Defects - Wei Liu; Sheng-Ning Zhang; Zong-Qiang Hu; Shi-Ming Feng; Zhen-Hui Li; Shu-Feng Xiao; Hong-Shu Wang; Li Li (Tissue Engineering and Regenerative Medicine, 2019)

Review of Chinese atmospheric science research over the past 70 years: Atmospheric physics and atmospheric environment - Tijian Wang; Taichang Gao; Hongsheng Zhang; Maofa Ge; Hengchi Lei; Peichang Zhang; Peng Zhang; Chunsong Lu; Chao Liu; Hua Zhang; Qiang Zhang; Hong Liao; et al. (Science China Earth Sciences, 2019)

Identification of the quantitative trait loci controlling spike-related traits in hexaploid wheat (Triticum aestivum L.) - Pei Cao; Xiaona Liang; Hong Zhao; Bo Feng; Enjun Xu; Liming Wang; Yuxin Hu (Planta, 2019)

Neuroprotective Effects of AG490 in Neonatal Hypoxic-Ischemic Brain Injury - Feiya Li; Raymond Wong; Zhengwei Luo; Lida Du; Ekaterina Turlova; Luiz R. G. Britto; Zhong-Ping Feng; Hong-Shuo Sun (Molecular Neurobiology, 2019)

The Preparation of Biochar Particles from Sludge and Corncobs and Its Pb2+ Adsorption Properties - Yajun Hong; Zuxin Xu; Chenglian Feng; Dayong Xu; Fengchang Wu (Bulletin of Environmental Contamination and Toxicology, 2019)

Influence of Hardness and Dissolved Organic Carbon on the Acute Toxicity of Copper to Zebrafish (Danio rerio) at Different Life Stages - Wei Liao; Chenglian Feng; Na Liu; Daqing Liu; Zhenfei Yan; Yingchen Bai; Hengwang Xie; Hong Shi; Daishe Wu (Bulletin of Environmental Contamination and Toxicology, 2019)

Optimizing the wavefield storage strategy in reflection-acoustic logging reverse-time migration - Yu-Sheng Li; Ning Li; Ye Yuan; Hong-Liang Wu; Zhou Feng; Peng Liu (Applied Geophysics, 2019)

A new protostane-type triterpenoid from Alisma plantago-aquatica subsp. orientale (Sam.) Sam - Hong-Mei Li; Dan Liu; Wei-Feng Dai; Xuan-Qin Chen; Rong-Tao Li (Natural Product Research, 2019)