Experimental and kinetic study on laminar burning velocities of NH3/CH4/H2S/air flames - Runfan Zhu; Xinlu Han; Ziyue Zhang; Yong He; Zhihua Wang (Fuel, 2023)

Small-sized Ni nanoparticles embedded nickel phyllosilicate as a metal-acid bifunctional zeolite catalyst for cooperatively boosting CO2-CH4 reforming - Chengming Huang; Yiming Zhang; Dingmei Han; Binbin He; Xinyu Sun; Meiyu Liu; Yi Mei; Yun Zu (Fuel, 2023)

Electron beam irradiation pretreatment enhances the formation of granular starch-phenolics complexes - Yuefeng Huang; Qiuyan Liu; Jiangtao Yu; Qiang Zhang; Caian He; Lin Han; Min Wang (Food Research International, 2023)

Region, vintage, and grape maturity co-shaped the ionomic signatures of the Cabernet Sauvignon wines - Xiao Han; Hao-Cheng Lu; Yu Wang; Xiao-Tong Gao; Hui-Qing Li; Meng-Bo Tian; Ning Shi; Ming-Yu Li; Xiao-Li Yang; Fei He; Chang-Qing Duan; Jun Wang (Food Research International, 2023)

Identification of ISG15 in golden pompano, Trachinotus ovatus, and its role in virus and bacteria infections - Lin Huang; Yuan Cheng; Shuyu Han; Mingzhu Liu; Qing Yu; Hongling Wei; Jinzhao He; Pengfei Li (Fish & Shellfish Immunology, 2023)

Dynamic variation and inhalation exposure of organophosphates esters and phthalic acid esters in face masks - Can Wang; Zi-Han Su; Ming-Jing He (Environmental Pollution, 2023)

A new strategy for mass production of single-atom catalysts for high performance of CO2 electrochemical reduction - Shitao Han; Shuaiqiang Jia; Wei Xia; Xueqing Xing; Ruijuan Qi; Haihong Wu; Mingyuan He; Buxing Han (Chemical Engineering Journal, 2023)

In-situ construction of carbon cloth-supported amorphous/crystalline hybrid NiCo-sulfide with permeable concrete-like morphology for high-performance solid-state hybrid supercapacitors - Xingchang Tang; Jingruo Wang; Deyi Zhang; Bing Wang; Xu Xia; Xianxin Meng; Biao Yang; Jianpeng Chen; Yulian He; Zhiyong Han (Chemical Engineering Journal, 2023)

An improved model assessing variation characteristics of pore structure of sandy soil thawing from extremely low temperature using NMR technique - Bo Liu; Yanqing He; Yanhui Han; Ting Li; Dongyang Li; Rong Gao (Cold Regions Science and Technology, 2023)

Enhanced cellulosic d-lactic acid production from sugarcane bagasse by pre-fermentation of water-soluble carbohydrates before acid pretreatment - Zhongyang Qiu; Xushen Han; Anqing Fu; Yalan Jiang; Wenyue Zhang; Ci Jin; Dengchao Li; Jun Xia; Jianlong He; Yuanfang Deng; Ning Xu; Xiaoyan Liu; et al. (Bioresource Technology, 2023)

Spatio-temporal changes in daily extreme precipitation for the Lancang–Mekong River Basin - Qiongfang Li; Tianshan Zeng; Qihui Chen; Xingye Han; Xi Weng; Pengfei He; Zhengmo Zhou; Yao Du (Natural Hazards, 2023)

Association between placental DNA methylation and fetal congenital heart disease - Jingjing Liu; Yuduo Wu; Hairui Sun; Xiaowei Liu; Xiaoyan Gu; Ye Zhang; Ying Zhao; Jiancheng Han; Yihua He (Molecular Genetics and Genomics, 2023)

Optimization of clofibrate with natural product sesamol for reducing liver injury induced by acetaminophen - Chuchu Han; Linyang Zhang; Yuxin Hua; Haitao Liu; Jiping Liu; Yongheng Shi; Xiaoping Wang; Wei Wang; Yi Jiang; Huawei Zhang; Chong Deng; Yundong Xie; et al. (Medicinal Chemistry Research, 2023)

A novel stochastic generation method of shale blocks in S-RM considering the particle size effect of morphological features - Chang Liu; Han Zhang; Xinli Hu; Shuangshuang Wu; Xu He; Peng Xia (Bulletin of Engineering Geology and the Environment, 2023)

Nuclear thermal coupling optimization of baffled NTP reactor - Zimian Duan; Jing Zhang; Zichao Han; Mingjun Wang; Yingwei Wu; Yanan He; Wenxi Tian; Siuzheng Qiu; G.H. Su (Annals of Nuclear Energy, 2023)

Recovery of nutrients from aquaculture wastewater: Effects of light quality on the growth, biochemical composition, and nutrient removal of Chlorella sorokiniana - Yuqing He; Jie Lian; Lan Wang; Lu Tan; Fahad Khan; Yanhua Li; Hongxia Wang; Céline Rebours; Danxiang Han; Qiang Hu (Algal Research, 2023)

Isochrysis sp. cultivation in pilot-scale to concurrently produce sustainable triacylglycerols for human milk fat substitutes and fucoxanthin - Daogui Li; Na Chen; Zhihua Zhou; Cairong Zhong; Jingping Fang; Luqiang Huang; Han Sun; Chengdeng Chi; Youcai Zhou; Yongjin He (Algal Research, 2023)

A sustainable approach to narrowing the summer maize yield gap experienced by smallholders in the North China Plain - Hongzhang Wang; Hao Ren; Lihua Zhang; Yali Zhao; Yuee Liu; Qijin He; Geng Li; Kun Han; Jiwang Zhang; Bin Zhao; Baizhao Ren; Peng Liu (Agricultural Systems, 2023)

Analysis of space debris impact source localization based on PVDF piezoelectric film - Enling Tang; Chengrui Xie; Kai Guo; Yafei Han; Chuang Chen; Mengzhou Chang; Liping He (Advances in Space Research, 2023)

Analysis of mechanism, properties and existing problems of liquid setting accelerators - Fei Ye; Biao He; Chongming Tian; Jian Wang; Xingbo Han; Guifeng Song; Qinglong Wang (European Journal of Environmental and Civil Engineering, 2022)

Correction to: Hsp20 Promotes Endothelial Progenitor Cell Angiogenesis via Activation of PI3K/Akt Signaling Pathway Under Hypoxia - Zhiqi Han; Xuan He; Yuan Feng; Weidong Jiang; Nuo Zhou; Xuanping Huang (Tissue Engineering and Regenerative Medicine, 2022)

Hsp20 Promotes Endothelial Progenitor Cell Angiogenesis via Activation of PI3K/Akt Signaling Pathway under Hypoxia - Zhiqi Han; Xuan He; Yuan Feng; Weidong Jiang; Nuo Zhou; Xuanping Huang (Tissue Engineering and Regenerative Medicine, 2022)

TRG16, targeted by miR-765, inhibits breast cancer stem cell-like properties via regulating the NF-κB pathway - Feng Chi; Xiaoming Jin; Long Chen; Guijin He; Sijia Han (Molecular and Cellular Biochemistry, 2022)

Exogenous melatonin improved the growth and development of naked oat seedlings under cadmium stress - Kai Wang; Jinjin He; Yu Gao; Kai Han; Jiaqi Liu; Yingjuan Wang (Environmental Science and Pollution Research, 2022)

Distribution of sediment microbial communities and their relationship with surrounding environmental factors in a typical rural river, Southwest China - Cheng Yang; Zhuo Zeng; Han Zhang; Dongdong Gao; Yuanyuan Wang; Guangyi He; Ying Liu; Yan Wang; Xinyu Du (Environmental Science and Pollution Research, 2022)

Rock thin sections identification under harsh conditions across regions based on online transfer method - Biao Wang; Guoqing Han; He Ma; Liying Zhu; Xingyuan Liang; Xin Lu (Computational Geosciences, 2022)

Immunogenicity and protective efficacy of a DNA vaccine inducing optimal expression of the SARS-CoV-2 S gene in hACE2 mice - Zhuo-xin Li; Sheng Feng; He Zhang; Xin-yu Zhuang; Chao Shang; Shi-yu Sun; Ji-cheng Han; Yu-biao Xie; Jin-yong Zhang; Wei Wang; Cheng-hui Li; Guan-yu Zhao; et al. (Archives of Virology, 2022)

Taberdines L and M, two new alkaloids from Tabernaemontana divaricata - Lingling Han; Kepu Huang; Chen Chen; Wentao Zhu; Yehan Ma; Xiaojiang Hao; Hongping He; Yu Zhang (Natural Product Research, 2022)

The association between several autophagy-related genes and their prognostic values in hepatocellular carcinoma: a study on the foundation of TCGA, GEPIA and HPA databases - Xueying Zhao; Shangqi Yin; Jingren Shi; Mei Zheng; Chaonan He; Huan Meng; Ying Han; Jin Chen; Jinyu Han; Zhengrong Yuan; Yajie Wang (Molecular Biology Reports, 2022)

High levels of serum IL-10 indicate disease progression, extramedullary involvement, and poor prognosis in multiple myeloma - Xiaoyan Yue; Linlin Huang; Yang Yang; Yi Zhao; Donghua He; Xiaoyan Han; Gaofeng Zheng; Yi Li; Enfan Zhang; Zhen Cai; Xin Huang; Jingsong He (Journal of Zhejiang University-SCIENCE B, 2022)

Spatial patterns of phytoplankton communities in an International Seabed Authority licensed area (COMRA, Clarion-Clipperton Zone) in relation to upper ocean biogeochemistry - Yu Wang; Aiqin Han; Xuebao He; Fangfang Kuang; Feng Zhao; Peng Xiang; Kuidong Xu (Acta Oceanologica Sinica, 2022)

Lignans from Bupleurum marginatum and their antioxidant activity - Jian Zhou; Xin He; Rongjin Sun; Zhenlong Yu; Chao Wang; Sa Deng; Baojing Zhang; Shanshan Huang; Chunhui Han; Dawei Li (Natural Product Research, 2022)

The impact of the risk of build failure on energy consumption in additive manufacturing - Han Wang; Martin Baumers; Shreeja Basak; Yinfeng He; Ian Ashcroft (Journal of Industrial Ecology, 2022)
Additive manufacturing (AM), also known as 3D printing, is associated with significant promise in the manufacturing sector. However, it has been shown that the risk of build failure has a substantial impact on the costs of AM and that this results from a relatively high level of process instability. Importantly, for such a promising technology, the effects of the risk of build failure on energy consumption have not yet been studied, which creates a significant gap in the knowledge of the real environmental performance of AM. This research addresses this gap by investigating the energy consumption of AM subject to the possibility of build failure. This is done by constructing a novel expected energy consumption model, integrating process energy consumption, the energy embedded in the raw material, and the probability of build failure as a function of the number of layers deposited. Model parameters are obtained from a series of build experiments conducted on the AM technology variant polymeric laser sintering, also known as laser powder bed fusion of polymers. The energy consumption model shows that the risk of build failure accounts for a substantial share of overall expected energy consumption, amounting to up to approximately 31% at full capacity utilization. Additionally, this paper uncovers a complex relationship between the risk of build failure and efficiency gains in per unit energy consumption resulting from increasing levels of capacity utilization (Supporting Information S1 ).

Cytokine storm and targeted therapy in hemophagocytic lymphohistiocytosis - Han-qi Zhang; Si-Wei Yang; Yi-Cheng Fu; Ming-Cong Chen; Cheng-Hao Yang; Ming-Hua Yang; Xiao-Dan Liu; Qing-Nan He; Hua Jiang; Ming-Yi Zhao (Immunologic Research, 2022)

Construction of a core germplasm bank of upland cotton (Gossypium hirsutum L.) based on phenotype, genotype and favorable alleles - Peng Han; Xiaomin Tian; Ying Wang; Cong Huang; Yizan Ma; Xiaofeng Zhou; Yu Yu; Dawei Zhang; Haijiang Xu; Yang Cao; Bo Zhu; Zhenxiu Feng; et al. (Genetic Resources and Crop Evolution, 2022)

Development and characterization of microsatellite markers for the rubber tree powdery mildew pathogen Oidium heveae - Qiaohui Han; Yongxiang He; Haiyan Che; Daquan Luo; Jonathan S. West; Xueren Cao (European Journal of Plant Pathology, 2022)

Facile synthesis of cadmium-doped graphite carbon nitride for photocatalytic degradation of tetracycline under visible light irradiation - Yin Zhao; Hong Qin; Ziwei Wang; Han Wang; Yangzhuo He; Quyang Tian; Qianlan Luo; Piao Xu (Environmental Science and Pollution Research, 2022)

Exosomal targeting and its potential clinical application - Jiao He; Weihong Ren; Wei Wang; Wenyan Han; Lu Jiang; Dai Zhang; Mengqi Guo (Drug Delivery and Translational Research, 2022)
Exosomes are extracellular vesicles secreted by a variety of living cells, which have a certain degree of natural targeting as nano-carriers. Almost all exosomes released by cells will eventually enter the blood circulation or be absorbed by other cells. Under the action of content sorting mechanism, some specific surface molecules can be expressed on the surface of exosomes, such as tetraspanins protein and integrin. To some extent, these specific surface molecules can fuse with specific cells, so that exosomes show specific cell natural targeting. In recent years, exosomes have become a drug delivery system with low immunogenicity, high biocompatibility and high efficacy. Nucleic acids, polypeptides, lipids, or small molecule drugs with therapeutic function are organically loaded into exosomes, and then transported to specific types of cells or tissues in vivo, especially tumor tissues, to achieve targeting drug delivery. The natural targeting of exosome has been found and recognized in some studies, but there are still many challenges in effective clinical treatments. The use of the natural targeting of exosomes alone is incapable of accurately transporting the goods loaded to specific sites. Besides, the natural targeting of exosomes is still an open question in disease targeting and efficient gene/chemotherapy combined therapy. Engineering transformation and modification on exosomes can optimize its natural targeting and deliver the goods to a specific location, providing wide use in clinical treatment. This review summarizes the research progress of exosomal natural targeting and transformation strategy of obtained targeting after transformation. The mechanism of natural targeting and obtained targeting after transformation are also reviewed. The potential value of exosomal targeting in clinical application is also discussed. Graphical abstract

Metabacillus rhizolycopersici sp. nov., Isolated from the Rhizosphere Soil of Tomato Plants - Rong Ma; Shan-Wen He; Xing Wang; Kyu Kyu Thin; Ji-Gang Han; Xiao-Xia Zhang (Current Microbiology, 2022)

Study on geometry and seepage evolution mechanism of fracture channels in granular filling coal - Zhen Liu; Shuangyue Wang; He Yang; Bo Cheng; Jing Han (Bulletin of Engineering Geology and the Environment, 2022)

Model study on backfill grouting in shield tunnels based on fractal theory - Nan Qin; Fei Ye; Biao He; Xing Liang; XingBo Han; EnJie Su (European Journal of Environmental and Civil Engineering, 2022)

Wheat genomic study for genetic improvement of traits in China - Jun Xiao; Bao Liu; Yingyin Yao; Zifeng Guo; Haiyan Jia; Lingrang Kong; Aimin Zhang; Wujun Ma; Zhongfu Ni; Shengbao Xu; Fei Lu; Yuannian Jiao; et al. (Science China Life Sciences, 2022)

The Rhizosphere Microbial Index Reflects the Optimal Restoration Pattern and the Nutrient Preference of Rhizosphere Microbes of Typical Plants in a Desertified Environment - Boyuan Bi; Chuanyu Wan; Qian Tong; Kun Wang; He Zhang; Yu Wang; Fengpeng Han (Journal of Soil Science and Plant Nutrition, 2022)

Cardiometabolic traits mediate the association of past shift work and chronic kidney disease: the Dongfeng–Tongji cohort study - Xu Han; Fei Wang; Jing Wang; Meian He (International Archives of Occupational and Environmental Health, 2022)

Correction to: Decomposition of China’s regional carbon emission paths: an analysis of environmental input and output considering regional development differences - Xueying Sun; Xiaojun Ma; Feng Shi; Miaomiao Han; Haiyang Xie; Yuan He (Environmental Science and Pollution Research, 2022)

Decomposition of China’s regional carbon emission paths: an analysis of environmental input and output considering regional development differences - Xueying Sun; Xiaojun Ma; Feng Shi; Miaomiao Han; Haiyang Xie; Yuan He (Environmental Science and Pollution Research, 2022)

Distribution characteristics of microplastics in the soil of mangrove restoration wetland and the effects of microplastics on soil characteristics - Bo Hu; Peiyong Guo; Siyu Han; Yifan Jin; Yiting Nan; Jun Deng; Junming He; Yaqing Wu; Sijia Chen (Ecotoxicology, 2022)

Ameliorating Inflammation in Insulin-resistant Rat Adipose Tissue with Abdominal Massage Regulates SIRT1/NF-κB Signaling - Tianjiao Gao; Shaotao Chen; Yiran Han; Dongmei Zhang; Yi Tan; Yutao He; Mingjun Liu (Cell Biochemistry and Biophysics, 2022)
It was the aim of this study to determine whether abdominal massage reverses high-fat diet-induced insulin resistance compared with RSV treatment. A total of sixty male Sprague-Dawley rats were randomly placed in one of four groups:the non-fat diet (NFD), the high-fat diet (HFD), the HFD with abdominal massage (HFD+ AM), and the HFD plus resveratrol (HFD+ RSV). For eight weeks, rats were fed high-fat diets to create insulin resistance, followed by six weeks of either AM or RSV. Molecular mechanisms of adipogenesis and cytokine production in rats with high-fat diets were investigated. The model rat adipose tissue showed significant improvements in obesity, glucose intolerance, and the accumulation of lipid in the body [the total cholesterol level (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C)], metabolic effects of glucose [The fasting blood glucose (FBG), Fasting insulin levels (FINS)], inflammatory status [interleukin-6 (IL-6) and tumor necrosis factor (TNF)-α, C-reactive protein (CRP)], and macrophage polarization after AM or RSV treatment. Further, AM increased SIRT1/NF-κB signaling in rat adipose tissue. Accordingly, in rat adipose tissue, our results indicate that AM regulates the secretion of proinflammatory cytokines, blood sugar levels, and related signaling pathways, contributing to improvement of IR, which may serves as a new therapeutic approach for the treatment for IR.

Cellular Heterogeneity and Plasticity of Skin Epithelial Cells in Wound Healing and Tumorigenesis - Jingru Wang; Jia He; Meishu Zhu; Yan Han; Ronghua Yang; Hongwei Liu; Xuejuan Xu; Xiaodong Chen (Stem Cell Reviews and Reports, 2022)
Cellular differentiation, the fundamental hallmark of cells, plays a critical role in homeostasis. And stem cells not only regulate the process where embryonic stem cells develop into a complete organism, but also replace ageing or damaged cells by proliferation, differentiation and migration. In characterizing distinct subpopulations of skin epithelial cells, stem cells show large heterogeneity and plasticity for homeostasis, wound healing and tumorigenesis. Epithelial stem cells and committed progenitors replenish each other or by themselves owing to the remarkable plasticity and heterogeneity of epidermal cells under certain circumstance. The development of new assay methods, including single-cell RNA sequence, lineage tracing assay, intravital microscopy systems and photon-ablation assay, highlight the plasticity of epidermal stem cells in response to injure and tumorigenesis. However, the critical mechanisms and key factors that regulate cellular plasticity still need for further exploration. In this review, we discuss the recent insights about the heterogeneity and plasticity of epithelial stem cells in homeostasis, wound healing and skin tumorigenesis. Understanding how stem cells collaborate together to repair injury and initiate tumor will offer new solutions for relevant diseases. Graphical Abstract Schematic abstract of cellular heterogeneity and plasticity of skin epithelial cells in wound healing and tumorigenesis

Rapid Characterization of Landslide-Debris Flow Chains of Geologic Hazards Using Multi-method Investigation: Case Study of the Tiejiangwan LDC - Kun He; Bo Liu; Xiewen Hu; Ruichen Zhou; Chuanjie Xi; Guotao Ma; Mei Han; You Li; Gang Luo (Rock Mechanics and Rock Engineering, 2022)

Inhibition of visfatin alleviates sepsis-induced intestinal damage by inhibiting Hippo signaling pathway - Zhong-Shen Kuang; Yu-Xin Leng; Ning Yang; Zheng-Qian Li; Ya-Nan Zong; Deng-Yang Han; Yue Li; Jin-Dan He; Xing-Ning Mi; Zhu-Kai Cong; Xi Zhu; Chang-Yi Wu; et al. (Inflammation Research, 2022)
Background The aim of this study is to investigate role of Visfatin, one of the pro-inflammatory adipokines, in sepsis-induced intestinal injury and to clarify the potential mechanism. Methods C57BL/6 mice underwent cecal ligation and puncture (CLP) surgery to establish sepsis model in vivo. Intestinal epithelial cells were stimulated with LPS to mimic sepsis-induced intestinal injury in vitro. FK866 (the inhibitor of Visfatin) with or without XMU-MP-1 (the inhibitor of Hippo signaling) was applied for treatment. The expression levels of Visfatin, NF-κB and Hippo signaling pathways-related proteins were detected by western blot or immunohistochemistry. The intestinal cell apoptosis and intestinal injury were investigated by TUNEL staining and H&E staining, respectively. ELISA was used to determine the production of inflammatory cytokines. Results The expression of Visfatin increased in CLP mice. FK866 reduced intestinal pathological injury, inflammatory cytokines production, and intestinal cell apoptosis in sepsis mice. Meanwhile, FK866 affected NF-κB and Hippo signaling pathways. Additionally, the effects of FK866 on inflammatory response, apoptosis, Hippo signaling and NF-κB signaling were partly abolished by XMU-MP-1, the inhibitor of Hippo signaling. In vitro experiments also revealed that FK866 exhibited a protective role against LPS-induced inflammatory response and apoptosis in intestinal cells, as well as regulating NF-κB and Hippo signaling, whereas addition of XMU-MP-1 weakened the protective effects of FK866. Conclusion In short, this study demonstrated that inhibition of Visfatin might alleviate sepsis-induced intestinal injury through Hippo signaling pathway, supporting a further research on Visfatin as a therapeutic target.

The impact of digital economy on total factor carbon productivity: the threshold effect of technology accumulation - Dongri Han; Yingying Ding; Ziyi Shi; Yao He (Environmental Science and Pollution Research, 2022)

Diversity and functions of quorum sensing bacteria in the root environment of the Suaeda glauca and Phragmites australis coastal wetlands - Changfei He; Li Zheng; Wei Gao; Jinfeng Ding; Chengxuan Li; Xiyuan Xu; Bin Han; Qian Li; Shuai Wang (Environmental Science and Pollution Research, 2022)

Occurrence Characteristics of Saline-Lacustrine Shale-Oil in the Qianjiang Depression, Jianghan Basin, Central China - Zhongliang Sun; Zhiliang He; Furong Wang; Yuanjia Han; Sheng He; Yuguang Hou; Jing Luo; Youheng Zheng; Shiqiang Wu (Journal of Earth Science, 2022)

Community structure and co-occurrence network analysis of bacteria and fungi in wheat fields vs fruit orchards - Xinyu Cui; Huan He; Fengxiao Zhu; Xiaobo Liu; You Ma; Wenming Xie; Han Meng; Limin Zhang (Archives of Microbiology, 2022)

Enhancing or inhibiting apoptosis? The effects of ucMSC-Ex in the treatment of different degrees of traumatic pancreatitis - Zhao Zhirong; Han Li; He Yiqun; He Chunyang; Zhou Lichen; Tan Zhen; Wang Tao; Dai Ruiwu (Apoptosis, 2022)

Combined exogenous selenium and biochemical fulvic acid reduce Cd accumulation in rice - Lei He; Dao-You Huang; Bo Liu; Quan Zhang; Han-Hua Zhu; Chao Xu; Qi-Hong Zhu (Environmental Science and Pollution Research, 2022)

Rainstorm-induced large-scale landslides in Northeastern Chongqing, China, August 31 to September 2, 2014 - Bin Li; Yang Gao; Yueping Yin; Jiawei Wan; Kai He; Weile Wu; Han Zhang (Bulletin of Engineering Geology and the Environment, 2022)

Aberrant topological organization and age-related differences in the human connectome in subjective cognitive decline by using regional morphology from magnetic resonance imaging - Zhenrong Fu; Mingyan Zhao; Yirong He; Xuetong Wang; Xin Li; Guixia Kang; Ying Han; Shuyu Li (Brain Structure and Function, 2022)

Roseicella aquatilis sp. nov., isolated from freshwater lake - Dan-Dan Zhang; Ya-Nan Zhao; Rui-Han He; Yu-Qi Yan; Zong-Jun Du (Archives of Microbiology, 2022)

Development of SSR markers and genetic diversity analysis based on RAD-seq technology among Chinese populations of Daphnia magna - Shengman Zhang; Jingxiang Ding; Zheng Han; Siwei Chen; Yuchao Liu; Wenhui He; Peimin He (Molecular Biology Reports, 2022)

Experimental investigation of the hydraulic properties of large-scale irregular fractured rock masses in granite fault zones - Liang Guo; Xiaoyu He; Zhuhong Xiong; Han Chen; Jiao Zhu; Mingwei Liao; Hao Guo; Xiaozhao Li; Baoquan Wang; Min Zhang; Lei Xing (Hydrogeology Journal, 2022)

Effects of long-term exposure of norfloxacin on the HPG and HPT axes in juvenile common carp - Si-Qi Zhang; Xue-Li Zhao; Shu-Wen He; Shao-Ying Xing; Zhi-Han Cao; Ping Li; Zhi-Hua Li (Environmental Science and Pollution Research, 2022)

A novel information changing rate and conditional mutual information-based input feature selection method for artificial intelligence drought prediction models - Qiongfang Li; Xingye Han; Zhennan Liu; Pengfei He; Peng Shi; Qihui Chen; Furan Du (Climate Dynamics, 2022)

The formation of biogenic reef stone: from coral skeleton to reef rubble - Yixin Li; Fengjuan Wang; Zhiyong Liu; Jinyang Jiang; Tingyu Han; Xin Liao; Chunpeng He; Zuhong Lu (Journal of Oceanography, 2022)

China’s food security situation and key questions in the new era: A perspective of farmland protection - Xinyuan Liang; Xiaobin Jin; Bo Han; Rui Sun; Weiyi Xu; Hanbing Li; Jie He; Jin Li (Journal of Geographical Sciences, 2022)

A Shuttling Protein Kank1 Plays Important Role in the Sex Determination in Yellow Drum - Sha Sun; Jieping Liu; Sen Zhang; Qiwei He; Wei Han; Kun Ye; Fang Han; Wanbo Li; Zhiyong Wang (Frontiers in Marine Science, 2022)
Sex is one of the most important scientific topics, and the existence of sex dimorphism is a conserved feature in vertebrate taxa. The research on sex-determining genes and sex chromosome evolution is a hot topic in biology. The majority of sex-determining genes expressed in somatic cells, and reciprocal interactions between germ cells and somatic cells, are important for gonadal differentiation. However, the knowledge of how signals are transmitted between somatic cells and germ cells remains unclear. In this study, we confirmed the 36 dph was a sex determination critical stage in yellow drum through transcriptome analysis at the early development stages. We further found that Kank1 participated in the germ cells’ motility process in yellow drum through KEGG pathway analysis together with protein-protein interaction network. With the dual-luciferase reporter assay, we detected that Kank1 increased the transcription of dmrt1_Luc gene in CHO cells and 293T cells. Additionally, we observed that Kank1 was not only expressed in the cytoplasm but also in the nucleus in CHO cells through a fluorescence microscope. These results suggest that Kank1 acts as a shuttling protein as in humans and may play a difunctional role at the early gonad development stage in yellow drum, and it not only participated in the germ cells’ motility but also increased the expression of dmrt1 in yellow drum.

BSA‑seq and genetic mapping reveals AhRt2 as a candidate gene responsible for red testa of peanut - Kun Zhang; Mei Yuan; Han Xia; Liangqiong He; Jing Ma; Mingxiao Wang; Huiling Zhao; Lei Hou; Shuzhen Zhao; Pengcheng Li; Ruizheng Tian; Jiaowen Pan; et al. (Theoretical and Applied Genetics, 2022)

Correction to: Functions of Oligosaccharides in Improving Tomato Seeding Growth and Chilling Resistance - Jiuxing He; Wei Han; Juan Wang; Yuanchao Qian; Makoto Saito; Wenbo Bai; Jiqing Song; Guohua Lv (Journal of Plant Growth Regulation, 2022)

Analysis of Grain Yield Formation Components of Extra Heavy-Panicle-Type Mid-Season Indica Hybrid Rice - Xiaolong Zhong; Hafiz Athar Hussain; Bingbing Zhao; Manyu Huang; Saddam Hussain; Rong Xie; Linjun Cai; Han Yun; Guanghua He; Changwei Zhang (Journal of Plant Growth Regulation, 2022)

Cordycepin alleviates myocardial ischemia/reperfusion injury by enhancing autophagy via AMPK-mTOR pathway - Han Xu; Jing Cheng; Fei He (Journal of Physiology and Biochemistry, 2022)

The Epigenetic Regulation of OLIG2 by Histone Demethylase KDM6B in Glioma Cells - Aixia Sui; Biaogang Han; Wenjun Ren; Weiliang He; Chao Gao; Xiaohui Han; Shifeng Liu; Yan Zhang; Xueling Qi; Xiaoqiang Guo (Journal of Molecular Neuroscience, 2022)

Correction to: Effectiveness of Newmark‑based sampling strategy for coseismic landslide susceptibility mapping using deep learning, support vector machine, and logistic regression - Chuanjie Xi; Mei Han; Xiewen Hu; Bo Liu; Kun He; Gang Luo; Xichao Cao (Bulletin of Engineering Geology and the Environment, 2022)

Effectiveness of Newmark-based sampling strategy for coseismic landslide susceptibility mapping using deep learning, support vector machine, and logistic regression - Chuanjie Xi; Mei Han; Xiewen Hu; Bo Liu; Kun He; Gang Luo; Xichao Cao (Bulletin of Engineering Geology and the Environment, 2022)

Approximate analytical solution for seepage field of drained tunnel in vertically stratified phreatic aquifer - Wei Meng; Chuan He; Fang-yin Wu; Wen-bo Yang; Hao Kou; Zi-han Zhou; De-ping Guo; Hai-long Meng (Journal of Mountain Science, 2022)

Changes in plant inputs alter soil carbon and microbial communities in forest ecosystems - Jiguang Feng; Keyi He; Qiufang Zhang; Mengguang Han; Biao Zhu (Global Change Biology, 2022)
Global changes can alter plant inputs from both above‐ and belowground, which, thus, may differently affect soil carbon and microbial communities. However, the general patterns of how plant input changes affect them in forests remain unclear. By conducting a meta‐analysis of 3193 observations from 166 experiments worldwide, we found that alterations in aboveground litter and/or root inputs had profound effects on soil carbon and microbial communities in forest ecosystems. Litter addition stimulated soil organic carbon (SOC) pools and microbial biomass, whereas removal of litter, roots or both (no inputs) decreased them. The increased SOC under litter addition suggested that aboveground litter inputs benefit SOC sequestration despite accelerated decomposition. Unlike root removal, litter alterations and no inputs altered particulate organic carbon, whereas all detrital treatments did not significantly change mineral‐associated organic carbon. In addition, detrital treatments contrastingly altered soil microbial community, with litter addition or removal shifting it toward fungi, whereas root removal shifting it toward bacteria. Furthermore, the responses of soil carbon and microbial biomass to litter alterations positively correlated with litter input rate and total litter input, suggesting that litter input quantity is a critical controller of belowground processes. Taken together, these findings provide critical insights into understanding how altered plant productivity and allocation affects soil carbon cycling, microbial communities and functioning of forest ecosystems under global changes. Future studies can take full advantage of the existing plant detritus experiments and should focus on the relative roles of litter and roots in forming SOC and its fractions.

Positron Emission Tomography Molecular Imaging for Phenotyping and Management of Lymphoma - Xiaohui Zhang; Han Jiang; Shuang Wu; Jing Wang; Rui Zhou; Xuexin He; Shufang Qian; Shuilin Zhao; Hong Zhang; Ali Cahid Civelek; Mei Tian (Phenomics, 2022)

Andrographolide Attenuates Blood–Brain Barrier Disruption, Neuronal Apoptosis, and Oxidative Stress Through Activation of Nrf2/HO-1 Signaling Pathway in Subarachnoid Hemorrhage - Pian Gong; Wei Zhang; Changlin Zou; Shoumeng Han; Qi Tian; Jianfeng Wang; Peibang He; Yujia Guo; Mingchang Li (Neurotoxicity Research, 2022)

Curcumin Inhibits Cell Damage and Apoptosis Caused by Thapsigargin-Induced Endoplasmic Reticulum Stress Involving the Recovery of Mitochondrial Function Mediated by Mitofusin-2 - He-Yan Zhou; Yu-Ying Sun; Ping Chang; Han-Chang Huang (Neurotoxicity Research, 2022)

Sympathetic Nerve Mediated Spinal Glia Activation Underlies Itch in a Cutaneous T-Cell Lymphoma Model - Fang Tong; Qianru He; Wan-Jie Du; Huan Yang; Dongping Du; Shaofeng Pu; Qingjian Han (Neuroscience Bulletin, 2022)

Application of exogenous glycinebetaine alleviates lead toxicity in pakchoi (Brassica chinensis L.) by promoting antioxidant enzymes and suppressing Pb accumulation - Yu Ji; Yanfang Ren; Chuan Han; Wenjia Zhu; jinyu Gu; Junyu He (Environmental Science and Pollution Research, 2022)

Early changes to the extracellular space in the hippocampus under simulated microgravity conditions - Yajuan Gao; Hongbin Han; Jichen Du; Qingyuan He; Yanxing Jia; Junhao Yan; Hui Dai; Bin Cui; Jing Yang; Xunbin Wei; Liu Yang; Rui Wang; et al. (Science China Life Sciences, 2022)

Dopamine D1 receptors mediate methamphetamine-induced dopaminergic damage: involvement of autophagy regulation via the AMPK/FOXO3A pathway - Tao He; Chaojun Han; Chun Liu; Jiaojiao Chen; Huicui Yang; Longtai Zheng; John L. Waddington; Xuechu Zhen (Psychopharmacology, 2022)

Polysaccharide Krestin Prevents Alzheimer’s Disease-type Pathology and Cognitive Deficits by Enhancing Monocyte Amyloid-β Processing - Si-Han Chen; Chen-Yang He; Ying-Ying Shen; Gui-Hua Zeng; Ding-Yuan Tian; Yuan Cheng; Man-Yu Xu; Dong-Yu Fan; Cheng-Rong Tan; An-Yu Shi; Xian-Le Bu; Yan-Jiang Wang (Neuroscience Bulletin, 2022)

Optimizing the distribution and proportion of various active sites for better NH3-SCR property over Cu/SSZ-13 - Ziqian Liu; Han Jiang; Bin Guan; Yanfei Wei; Xingze Wu; He Lin; Zhen Huang (Environmental Science and Pollution Research, 2022)

Multivariate statistical analysis of potentially toxic elements in soils under different land uses: Spatial relationship, ecological risk assessment, and source identification - Yuejun He; Xiaoxiao Han; Jingsong Ge; Lingqing Wang (Environmental Geochemistry and Health, 2022)

Field investigation and numerical simulation on rockfalls in Zhangmu Town, Tibet, China - Zhong-fu Wang; Han-dong Liu; Si-ming He; Dan Bi (Journal of Mountain Science, 2022)

Development of 30 SNP markers for the Daphnia magna based on restriction-site associated DNA sequencing (RAD-seq) - Shengman Zhang; Yiran Xiong; Meng Tan; Zheng Han; Siwei Chen; Wenhui He; Peimin He (Conservation Genetics Resources, 2022)

Effects of Suspended Particles on Exopolysaccharide Secretion of Two Microalgae in Jinjiang Estuary (Fujian, China) - Jie Liu; Xiaoyu Han; Hui Xing; Yiting Nan; Jiahui Lin; Junming He; Sijia Chen; Yanfang Wei; Peiyong Guo (Journal of Marine Science and Engineering, 2022)
The effects of suspended particles (SP) of different concentrations and sizes on the secretion of exopolysaccharide (EPS) by Chlorella pyrenoidosa (C. pyrenoidosa) and Microcystis flos-aquae (M. flos-aquae) in Jinjiang Estuary, Fujian Province, China were studied in co-cultures of microalgae and SP. The results show that the SP concentration has an “inhibit–promote–inhibit” effect on the secretion of EPS by C. pyrenoidosa, whereby there is an optimal concentration of SP corresponding to the largest amount of EPS secreted by C. pyrenoidosa. Low concentrations had no significant effect on the secretion of EPS from M. flos-aquae (p > 0.05), whereas higher concentrations had an inhibitory effect. The C. pyrenoidosa EPS content was found to be significantly decreased in response to SP of small particle sizes (0–75 and 75–120 μm) and significantly increased for SP of large particle sizes (120–150 and 150–500 μm). Small particle sizes (0–75 and 75–120 μm) were found to be beneficial to the secretion of EPS from M. flos-aquae, and the promotion of EPS secretion gradually decreased with the increase in SP particle size. However, when the particle size was too large (120–150 and 150–500 μm), SP had no significant effect on EPS secretion. This study is helpful for understanding the microalgae EPS secretion response to SP and provides a scientific basis for studying the mechanism of EPS secretion by algae and the effect of SP on eutrophication of the estuary.

Ameliorating Effect of Umbilical Cord Mesenchymal Stem Cells in a Human Induced Pluripotent Stem Cell Model of Dravet Syndrome - Huifang Zhao; Shuai Li; Lang He; Feng Tang; Xiaobo Han; Weiyue Deng; Zuoxian Lin; Rongqi Huang; Zhiyuan Li (Molecular Neurobiology, 2022)

Circular RNA circ_0070441 regulates MPP+-triggered neurotoxic effect in SH-SY5Y cells via miR-626/IRS2 axis - Xuqing Cao; Jiangtao Guo; Hideki Mochizuki; Dong Xu; Tao Zhang; Haiping Han; Tingjie Ma; Mingshan Qi; Jing He (Metabolic Brain Disease, 2022)

Functions of Oligosaccharides in Improving Tomato Seeding Growth and Chilling Resistance - Jiuxing He; Wei Han; Juan Wang; Yuanchao Qian; Makoto Saito; Wenbo Bai; Jiqing Song; Guohua Lv (Journal of Plant Growth Regulation, 2022)

MicroRNA-451a attenuates angiotensin II–induced cardiac fibrosis and inflammation by directly targeting T-box1 - Hao-Yuan Deng; Ze-Yin He; Zhi-Chao Dong; Yun-Long Zhang; Xiao Han; Hui-Hua Li (Journal of Physiology and Biochemistry, 2022)

GATA4 Is a Transcriptional Regulator of SOX2 in Japanese Flounder (Paralichthys olivaceus) - Xiumei Liu; Zan Li; Weijie Yan; Haitao Zhao; Yuxiang Liu; Miao Han; Xubo Wang; Yan He; Haiyang Yu; Quanqi Zhang (Journal of Ocean University of China, 2022)

Research on Wetting Deformation Model of Coarse-Grained Materials of Earth-rock Dam - Hongyang Zhang; Pengju Han; Qin He; Yadong Sun; Ziyi Song; Zelin Ding; Ang Niu (Arabian Journal of Geosciences, 2022)

Petrogenesis of the Late Triassic Mengsong strongly peraluminous granites in the southeastern Tibetan Plateau: highly fractionated from crystal mush - Feng Cong; Fu-Yuan Wu; Wen-Chang Li; De-Feng He; Zai-Bo Sun; Xiao-Ming Huang; Zhi-Zhong Hu; Han Zhao (International Geology Review, 2022)

Carbon dots based ratiometric fluorescent sensing platform for food safety - Yong Han; Weixia Yang; Xueli Luo; Xie He; Haiping Zhao; Wenzhi Tang; Tianli Yue; Zhonghong Li (Critical Reviews in Food Science and Nutrition, 2022)

Bivalent Regulation and Related Mechanisms of H3K4/27/9me3 in Stem Cells - Han Sun; Yin Wang; Ying Wang; Feng Ji; An Wang; Ming Yang; Xu He; Lisha Li (Stem Cell Reviews and Reports, 2022)

Lactate shuttle: from substance exchange to regulatory mechanism - Xingchen Wang; He Liu; Yingqian Ni; Peibo Shen; Xiuzhen Han (Human Cell, 2022)

Comparative profiling of genome-wide small RNAs in non-heading Chinese cabbage [Brassica rapa subsp. chinensis (L.) Hanelt] - Xuxin Liu; Xiang Yu; Han Wang; Yuke He (Genetic Resources and Crop Evolution, 2022)

Tracing historical changes, degradation, and original sources of airborne polycyclic aromatic hydrocarbons (PAHs) in Jilin Province, China, by Abies holophylla and Pinus tabuliformis needle leaves - Zhao Wang; Xiangzi Jin; Han Yeong Kaw; Zakia Fatima; Maurizio Quinto; John L. Zhou; Dongri Jin; Miao He; Donghao Li (Environmental Science and Pollution Research, 2022)

Morphologic analysis of hysteretic behavior of China Laizhou Bay submarine mucky clay and its cyclic failure criteria - Song Dai; Bo Han; Ningbo Li; Baogang Wang; Ben He; Jian Liu (Bulletin of Engineering Geology and the Environment, 2022)

Effect of feed restriction on the intestinal microbial community structure of growing ducks - Jun-peng Li; Qi-fan Wu; Sheng-chao Ma; Jian-mei Wang; Bin Wei; Yang Xi; Chun-chun Han; Liang Li; Hua He; He-he Liu (Archives of Microbiology, 2022)

CRISPR-Cas systems are present predominantly on chromosome and its relationship with MEGs in Vibrio species - Enbao Zhang; Wei Zhou; Jinzhi Zhou; Ze He; Yuqiao Zhou; Jianzhong Han; Daofeng Qu (Archives of Microbiology, 2022)

Geochemical characteristics and origin of Chang-9 crude oil of Triassic Yanchang Formation in Zhidan area, Ordos Basin, China - Zhengyu Wu; Shijia Chen; Chengshan Li; Jian Yu; Yibo Chang; Zixing Lu; Xin He; Haifeng Zhang; Han Meimei (Arabian Journal of Geosciences, 2022)

Overview of the Processes Driving Exchange at Cape Hatteras Program - Harvey Seim; Dana Savidge; Magdalena Andres; John Bane; Catherine Edwards; Glen Gawarkiewicz; Ruoying He; Robert Todd; Michael Muglia; Joseph Zambon; Lu Han; Shun Mao (Oceanography, 2022)
The Processes driving Exchange At Cape Hatteras (PEACH) program seeks to better understand seawater exchanges between the continental shelf and the open ocean near Cape Hatteras, North Carolina. This location is where the Gulf Stream transitions from a boundary-trapped current to a free jet, and where robust along-shelf convergence brings cool, relatively fresh Middle Atlantic Bight and warm, salty South Atlantic Bight shelf waters together, forming an important and dynamic biogeographic boundary. The magnitude of this convergence implies large export of shelf water to the open ocean here. Background on the oceanography of the region provides motivation for the study and gives context for the measurements that were made. Science questions focus on the roles that wind forcing, Gulf Stream forcing, and lateral density gradients play in driving exchange. PEACH observational efforts include a variety of fixed and mobile observing platforms, and PEACH modeling included two different resolutions and data assimilation schemes. Findings to date on mean circulation, the nature of export from the southern Middle Atlantic Bight shelf, Gulf Stream variability, and position variability of the Hatteras Front are summarized, together with a look ahead to forthcoming analyses.

miR-451-3p alleviates myocardial ischemia/reperfusion injury by inhibiting MAP1LC3B-mediated autophagy - Xiang-Wei Lv; Zi-Feng He; Pan-Pan Zhu; Qiu-Yu Qin; Yun-Xue Han; Tong-Tong Xu (Inflammation Research, 2021)

Have artificial lighting and noise pollution caused zoonosis and the COVID-19 pandemic? A review - Shanshan He; Wenyuan Shao; Jie Han (Environmental Chemistry Letters, 2021)

Spatial Distribution and Environmental Risk of Arsenic and Antimony in Soil Around an Antimony Smelter of Qinglong County - Yingping He; Zhiwei Han; Fuzhong Wu; Jia Xiong; Shangyi Gu; Pan Wu (Bulletin of Environmental Contamination and Toxicology, 2021)

Quantitative trait locus mapping and genomic selection of tobacco (Nicotiana tabacum L.) based on high-density genetic map - Zhijun Tong; Zhihui Xiu; Yao Ming; Dunhuang Fang; Xuejun Chen; Yafei Hu; Juhong Zhou; Weiming He; Fangchan Jiao; Chi Zhang; Shancen Zhao; Han Jin; et al. (Plant Biotechnology Reports, 2021)
Tobacco ( Nicotiana tabacum L.) is an economic crop and a model organism for studies of plant biology and genetics. As an allotetraploid plant generated from interspecific hybridization, tobacco has a massive genome (4.5 Gb). Recently, a genetic map with 45,081 single nucleotide polymorphism (SNP) markers was constructed using whole-genome sequencing data for a tobacco population including 274 individuals. This provides a basis for quantitative trait locus (QTL) mapping and genomic selection, which have been widely applied to other crops but have not been feasible in tobacco. Based on this high-density genetic map, we identified QTLs associated with important agronomic traits, chemical compounds in dry leaves, and hazardous substances in processed cigarettes. The LOD values for major QTLs were highest for agronomic traits, followed by chemical compounds and hazardous substances. In addition to the identification of molecular markers, we evaluated genomic selection models and found that BayesB had the highest prediction accuracy for the recombinant inbred line population. Our results offer new insights into the genetic mechanism underlying important traits, such as agronomic traits and quality-related chemical compounds in tobacco, and will be able to support the application of molecular breeding to tobacco.

City size and employment dynamics in China: Evidence from recruitment website data - Daquan Huang; Han He; Tao Liu (Journal of Geographical Sciences, 2021)

The Common Occurrence of Theileria ovis in Tibetan Sheep and the First Report of Theileria sinensis in Yaks from Southern Qinghai, China - Ye Wang; Bo Wang; Qingxun Zhang; Ying Li; Ziwen Yang; Shuyi Han; Guohui Yuan; Shuangling Wang; Hongxuan He (Acta Parasitologica, 2021)

Loganin ameliorates depression-like behaviors of mice via modulation of serotoninergic system - Chen-Hao Pan; Cong-Yuan Xia; Yu Yan; Yan Han; Rui Shi; Jun He; Ze-Xing Wang; Yu-Ming Wang; Wei-Ku Zhang; Jie-Kun Xu (Psychopharmacology, 2021)

A 168-year temperature recording based on tree rings and latitude differences in temperature changes in northeast China - Yangao Jiang; Yuting Cao; Junhui Zhang; Zhuo Li; Guoqiang Shi; Shijie Han; Cassius E. O. Coombs; Chuan Liu; Xiaoguang Wang; Junwei Wang; Lin Hao; Qi Xu; et al. (International Journal of Biometeorology, 2021)

Comparative transcriptome analysis reveals that deletion of CheY influences gene expressions of ABC transports and metabolism in Haemophilus parasuis - Lvqin He; Xuefeng Yan; Ke Dai; Xintian Wen; Sanjie Cao; Xiaobo Huang; Rui Wu; Qin Zhao; Yong Huang; Qigui Yan; Xiaoping Ma; Xinfeng Han; et al. (Functional & Integrative Genomics, 2021)

Characterization of the bacterioplankton community and the influencing factors in the upper reaches of the Han River basin - He Sun; Baozhu Pan; Haoran He; Gengnan Zhao; Xiaoming Jiang; Xu Han; Hao Wang (Environmental Science and Pollution Research, 2021)

Exposure to 2,4-dichlorophenol, 2,4,6-trichlorophenol, pentachlorophenol and risk of thyroid cancer: a case-control study in China - Wan-Jun Yang; Hua-Bing Wu; Chi Zhang; Qi Zhong; Ming-Jun Hu; Jia-Liu He; Guo-Ao Li; Zhen-Yu Zhu; Jin-Liang Zhu; Huan-Huan Zhao; Han-Shuang Zhang; Fen Huang (Environmental Science and Pollution Research, 2021)

Design and Characterization of HY-038 Solid Dispersions via Spray Drying Technology: In Vitro and In Vivo Evaluations - Taotao Jiang; Limei Han; Enhao Lu; Wenxiu He; Shilin Du; Xianyi Sha (AAPS PharmSciTech, 2021)

Carbon limitation overrides acidification in mediating soil microbial activity to nitrogen enrichment in a temperate grassland - Qiushi Ning; Stephan Hättenschwiler; Xiaotao Lü; Paul Kardol; Yunhai Zhang; Cunzheng Wei; Chengyuan Xu; Jianhui Huang; Ang Li; Junjie Yang; Jing Wang; Yang Peng; et al. (Global Change Biology, 2021)
Higher ecosystem nitrogen (N) inputs resulting from human activities often suppress soil microbial biomass and respiration, thereby altering biogeochemical cycling. Soil acidification and carbon (C) limitation may drive these microbial responses, yet their relative importance remains elusive, which limits our understanding of the longer term effects of increasing N inputs. In a field experiment with continuous N addition at seven different rates from 0 to 50 g N m −2 year −1 over 6 years in a temperate grassland of Inner Mongolia, China, we examined the responses of soil microbial biomass and respiration to changes in soil acidity and C availability by adding lime and/or glucose to soil samples. Soil microbial biomass and respiration did only weakly respond to increasing soil pH, but increased strongly in response to higher C availability with increasing N addition rates. Soil net N immobilization increased in response to glucose addition, and soil microbial biomass increased at higher rates than microbial respiration along the gradient of previous N addition rates, both suggesting increasingly reinforced microbial C limitation with increasing N addition. Our results provide clear evidence for strong N‐induced microbial C limitation, but only little support for soil acidity effects within the initial pH range of 4.73–7.86 covered by our study. Field data support this conclusion by showing reduced plant C allocation belowground in response to N addition, resulting in soil microbial C starvation over the long term. In conclusion, soil microbial biomass and respiration under N addition were strongly dependent on C availability, most likely originating from plant belowground C inputs, and was much less affected by changes in soil pH. Our data help clarify a long‐standing debate about how increasing N input rates affect soil microbial biomass and respiration, and improve the mechanistic understanding of the linkages between ecosystem N enrichment and C cycling.

Two new cephalochromin derivative from the Alternaria sp. ZG22 - Xin-Ming Song; Xue-Ming Zhou; Ya-Ling Li; Li-Bing Huang; Cai-Cui Chen; Yan Gao; Lin He; Xiao-qun Mao; Bing Chen; Jing-Wen Liu; Hui-Jie Liu; Xiao-Ping Song; et al. (Natural Product Research, 2021)

Deformation and cooling history of the Central Qiangtang terrane, Tibetan Plateau and its tectonic implications - Wenjun Bi; Zhongpeng Han; Yalin Li; Chengming Li; Chengshan Wang; Jiawei Zhang; Jianyun Han; Haiyang He; Xinyu Qian; Tiankun Xu; Zining Ma (International Geology Review, 2021)

Complement C3 Aggravates Post-epileptic Neuronal Injury Via Activation of TRPV1 - Guang-Tong Jiang; Lin Shao; Shuo Kong; Meng-Liu Zeng; Jing-Jing Cheng; Tao-Xiang Chen; Song Han; Jun Yin; Wan-Hong Liu; Xiao-Hua He; Yu-Min Liu; Lanzi Gongga; et al. (Neuroscience Bulletin, 2021)

Defective Autophagy and Mitophagy in Alzheimer’s Disease: Mechanisms and Translational Implications - Jie Chen; Hai-Jun He; Qianqian Ye; Feifei Feng; Wen-Wen Wang; Yingying Gu; Ruiyu Han; Chenglong Xie (Molecular Neurobiology, 2021)

Development and formation of ground fissures induced by an ultra large mining height longwall panel in Shendong mining area - Xiang He; Yixin Zhao; Ke Yang; Cun Zhang; Penghua Han (Bulletin of Engineering Geology and the Environment, 2021)

Hydrogeochemical characteristic evaluation and irrigation suitability assessment of shallow groundwater in Dangshan County, China - Lei Ma; Tingwei Huang; Han Qiu; Zhangxian Yang; Xiaorui He; Jiazhong Qian (Geosciences Journal, 2021)

Expression analysis and tissue localization of IgZ in the grouper Epinephelus coioides after Vibrio alginolyticus infection and vaccination - Yao‐Wu Fu; Zhan‐Juan Yao; Meng‐Han He; Zuo‐Pei Wang; Wei‐Feng Chen; Miao Cui; Qi‐Zhong Zhang (Journal of Fish Diseases, 2021)
The orange‐spotted grouper ( Epinephelus coioides ) is an important marine farmed fish in China. It is affected by the bacterial pathogen Vibrio alginolyticus , which causes high mortality and substantial economic losses. We studied the transcriptional changes of the IgZ gene in E. coioides following V. alginolyticus stimulation and investigated the distribution of IgZ in different tissues. The highest expression level of IgZ occurred in the head kidney. When fish were stimulated with live and inactivated V. alginolyticus , the expression levels of IgZ in the head kidney, spleen, intestine, gills and blood cells were significantly upregulated. In an in situ hybridization study, IgZ mRNA‐positive cells were detected in the head kidney, spleen and gill, but positive signals were not detected in the liver and intestine. IgZ‐labelled cells increased in the head kidney, spleen and gills post‐infection with V. alginolyticus for 21 days. The present study provides additional evidence that IgZ is involved in mucosal immune responses and helps explain the role of IgZ in E . coioides defence against V . alginolyticus infection.

Shifts in Nitrogen Removal Performance and Microbial Communities in Constructed Wetlands After Short-term Exposure to Titanium Dioxide Nanoparticles - Rui Han; Kexin Li; Chenzheng We; Tao He; Jingru Liu; Renduo Zhang; Li Wan; Yinghai Wu (Water, Air, & Soil Pollution, 2021)

Integration of small RNAs, degradome, and transcriptome sequencing provides insights into the differences between Shizhu ginseng and Yuan ginseng - Mengyuan Peng; Yanlin Chen; Wenjuan Wang; Zhihua He; Wangqiang Dai; Zhiyun Lin; Zemin Yang; Mengjuan Gong; Yongqin Yin; Bin Han; Yu Zeng; Yingfang Wang (Journal of Plant Biochemistry and Biotechnology, 2021)
Panax ginseng is one of the most popular herbs which have been used as an important traditional Chinese medicine since ancient times. Yuan ginseng and Shizhu ginseng,which belong to P. ginseng , are widely used as substitutes for wild ginseng in clinical practice. Clinical practice has proved that the clinical efficacy of Shizhu ginseng is better than Yuan ginseng. However, current research cannot completely explain this phenomenon. Considering that small RNA may be one of the pharmacodynamic substances of P. ginseng , it is challenging to investigate differential miRNAs between Shizhu ginseng and Yuan ginseng. In this study, the transcriptome, small RNAome and degradome of P. ginseng were studied by high-throughput sequencing. A total of 63,875 unigenes and 43,950,137 small RNA clean reads were obtained from the roots of P. ginseng . Among 3206 differentially expressed genes, 1190 genes were up-regulated in Yuan ginseng when compared with Shizhu ginseng. 24 known differential miRNAs and 7 novel differential miRNAs were obtained. The 304 targets of 24 differentially expressed miRNA (17 known and 7 novel) families are mainly related to energy metabolism, biotic stress and disease immunity in ginseng itself. Through the association analysis of mRNA and miRNA, our work gives a better understanding of the difference between Yuan ginseng and Shizhu ginseng. Considering the cross-kingdom regulation of plant miRNAs, our results may provide a foundation for understanding the miRNA-dependent clinical efficacy in P. ginseng .

Comparison of fungal community composition within different intestinal segments of tilapia and bighead carp - Lei Zhou; Yaoquan Han; Dapeng Wang; Yusen Li; Xiande Huang; Anyou He (Journal of Oceanology and Limnology, 2021)

The Preventive Effects of Lactobacillus casei on Acute Lung Injury Induced by Lipopolysaccharide - Lihui Zhao; Ying Mao; Haiming Yu; He Liu; Chao Wang; Jianwei Liu; Yutong Han; Yang Bi; Donghai Zhang (Indian Journal of Microbiology, 2021)

Ethylene‐regulated leaf lifespan explains divergent responses of plant productivity to warming among three hydrologically different growing seasons - Haiyan Ren; Guodong Han; Mai‐He Li; Cuiping Gao; Lin Jiang (Global Change Biology, 2021)
Leaf senescence is known to be regulated by the plant hormone ethylene, but how leaf lifespan responds to global environmental change and links to ecosystem‐level responses remains largely unexplored. Here we investigated the effects of climate warming and nitrogen addition on plant functional traits, plant hormone ethylene and net primary production in a 13‐year field experiment in a desert steppe. Across the last 3 years of the experiment (2016–2018), plant productivity increased under warming only in 2016, when there was above normal precipitation, but consistently increased with nitrogen addition. Warming enhanced net photosynthesis, leaf nitrogen and ethylene production and reduced leaf lifespan in 2016 (a wet year), but not in 2017 (a drought year); the effect of warming in 2018 (a year with normal precipitation) was opposite to 2016, likely due to the below‐normal precipitation in the mid‐growing season in 2018. Nitrogen addition led to increases in leaf nitrogen, ethylene production and net photosynthesis, and declines in leaf lifespan in 2016 and 2018, but not in 2017. The ethylene‐regulated lifespan was further evidenced by the addition of CoCl 2 (an ethylene biosynthesis inhibitor) that reduced ethylene production and prolonged lifespan. Structural equation modeling showed that leaf lifespan had a negative effect on plant productivity, both directly and indirectly via its negative effect on net photosynthesis, across all 3 years. Our results demonstrate the divergent responses of leaf lifespan and, in turn, plant productivity to warming under inter‐annual and intra‐annual precipitation variation, thus linking plant hormone production, functional traits and ecosystem functioning in the face of global environmental change.

Short-term effects of soil moisture on soil organic carbon decomposition in a coastal wetland of the Yellow River Delta - Wendi Qu; Guangxuan Han; Jian Wang; Juanyong Li; Mingliang Zhao; Wenjun He; Xinge Li; Siyu Wei (Hydrobiologia, 2021)

Dynamic characteristics and driving factors of vegetation greenness under changing environments in Xinjiang, China - Panxing He; Zongjiu Sun; Zhiming Han; Yiqiang Dong; Huixia Liu; Xiaoyu Meng; Jun Ma (Environmental Science and Pollution Research, 2021)

Temperature and Moisture Modulate the Contribution of Soil Fauna to Litter Decomposition via Different Pathways - Bo Tan; Rui Yin; Jian Zhang; Zhenfeng Xu; Yang Liu; Shuqin He; Li Zhang; Han Li; Lixia Wang; Sining Liu; Chengming You; Changhui Peng (Ecosystems, 2021)

Abnormal white matter microstructure along the thalamus fiber pathways in women with primary dysmenorrhea - Juan He; Wanghuan Dun; Fang Han; Ke Wang; Jing Yang; Shaohui Ma; Ming Zhang; Jixin Liu; Hongjuan Liu (Brain Imaging and Behavior, 2021)

Heavy metal pollution and ecological risk assessment of tailings in the Qinglong Dachang antimony mine, China - Guangfei Luo; Zhiwei Han; Jia Xiong; Yinping He; Jiahao Liao; Pan Wu (Environmental Science and Pollution Research, 2021)

Effects of reservoir water level fluctuations and rainfall on a landslide by two-way ANOVA and K-means clustering - Shuangshuang Wu; Xinli Hu; Wenbo Zheng; Chuncan He; Guangcheng Zhang; Han Zhang; Xuan Wang (Bulletin of Engineering Geology and the Environment, 2021)

Diel Feeding Rhythm and Grazing Selectivity of Small-Sized Copepods in a Subtropical Embayment, the Northern South China Sea - Xuejia He; Ziyu Wang; Ziqing Bai; Liuyu Han; Mianrun Chen (Frontiers in Marine Science, 2021)
Small marine copepods are key components of the pelagic food webs in Chinese coastal waters, but very few studies have addressed their trophodynamics, with even fewer studies addressing their diel feeding rhythms. In this study, the diel feeding rhythm and grazing selectivity of the copepod assemblage in Daya Bay during September 30 to October 2, 2014, were studied based on gut pigment analysis. Small copepods (body length < 1.5 mm) including Paracalanus parvus , Temora turbinata , Acrocalanus gibber , Temora stylifera , Euterpe acutifrons , and Acrocalanus gracilis , accounted for 73.9–100% of the total copepod abundance. The copepod assemblage generally exhibited a diurnal feeding pattern, characterized by a higher gut pigment content and ingestion rate during the daytime, consistent with variation in the ambient Chl α concentration. Fifty-five percent of the phytoplankton standing stock per day was consumed by the copepod assemblage, wherein diatoms, prymnesiophytes, and cyanobacteria were the main prey items with average contributions of 19.4–32.9% to the gut pigment contents. The copepod assemblage showed a strong feeding preference for prymnesiophytes, a weak feeding preference for diatoms, and avoidance of cyanobacteria. These results suggest a strong top-down control on phytoplankton community, especially on small groups from small copepods in the Daya Bay ecosystem.

Genetic Architecture of Childhood Kidney and Urological Diseases in China - Ye Fang; Hua Shi; Tianchao Xiang; Jiaojiao Liu; Jialu Liu; Xiaoshan Tang; Xiaoyan Fang; Jing Chen; Yihui Zhai; Qian Shen; Guomin Li; Li Sun; et al. (Phenomics, 2021)
Kidney disease is manifested in a wide variety of phenotypes, many of which have an important hereditary component. To delineate the genotypic and phenotypic spectrum of pediatric nephropathy, a multicenter registration system is being implemented based on the Chinese Children Genetic Kidney Disease Database (CCGKDD). In this study, all the patients with kidney and urological diseases were recruited from 2014 to 2020. Genetic analysis was conducted using exome sequencing for families with multiple affected individuals with nephropathy or clinical suspicion of a genetic kidney disease owing to early-onset or extrarenal features. The genetic diagnosis was confirmed in 883 of 2256 (39.1%) patients from 23 provinces in China. Phenotypic profiles showed that the primary diagnosis included steroid-resistant nephrotic syndrome (SRNS, 23.5%), glomerulonephritis (GN, 32.2%), congenital anomalies of the kidney and urinary tract (CAKUT, 21.2%), cystic renal disease (3.9%), renal calcinosis/stone (3.6%), tubulopathy (9.7%), and chronic kidney disease of unknown etiology (CKDu, 5.8%). The pathogenic variants of 105 monogenetic disorders were identified. Ten distinct genomic disorders were identified as pathogenic copy number variants (CNVs) in 11 patients. The diagnostic yield differed by subgroups, and was highest in those with cystic renal disease (66.3%), followed by tubulopathy (58.4%), GN (57.7%), CKDu (43.5%), SRNS (29.2%), renal calcinosis /stone (29.3%) and CAKUT (8.6%). Reverse phenotyping permitted correct identification in 40 cases with clinical reassessment and unexpected genetic conditions. We present the results of the largest cohort of children with kidney disease in China where diagnostic exome sequencing was performed. Our data demonstrate the utility of family-based exome sequencing, and indicate that the combined analysis of genotype and phenotype based on the national patient registry is pivotal to the genetic diagnosis of kidney disease.

Regulation of mGluR1 on the Expression of PKC and NMDAR in Aluminum-Exposed PC12 Cells - Chanting He; Xiaoyan Zhao; Huan Li; Fei Wang; Jingsi Zhang; Yanni Wang; Yingchao Han; Chunman Yuan; Qiao Niu (Neurotoxicity Research, 2021)

Effect of juvenile omni-benthivorous fish (Carassius carassius) disturbance on the efficiency of lanthanum-modified bentonite (LMB) for eutrophication control: a mesocosm study - Yanqing Han; Qisheng Li; Hu He; Jiao Gu; Zhaoshi Wu; Xiaolong Huang; Xiaojuan Zou; You Zhang; Kuanyi Li (Environmental Science and Pollution Research, 2021)

Clozapine Induced Developmental and Cardiac Toxicity on Zebrafish Embryos by Elevating Oxidative Stress - Feng Zhang; Liwen Han; Jiazhen Wang; Minglei Shu; Kechun Liu; Yun Zhang; ChungDer Hsiao; Qingping Tian; Qiuxia He (Cardiovascular Toxicology, 2021)

In vitro and In vivo Antibacterial Effects of Nisin Against Streptococcus suis - Haodan Zhu; Lixiao Han; Yanxiu Ni; Zhengyu Yu; Dandan Wang; Junming Zhou; Bin Li; Wei Zhang; Kongwang He (Probiotics and Antimicrobial Proteins, 2021)

Hydroxychloroquine use and progression or prognosis of COVID-19: a systematic review and meta-analysis - Yanxiang Zang; Xuejie Han; Meijiao He; Jing Shi; Yue Li (Naunyn-Schmiedeberg's Archives of Pharmacology, 2021)

Genome‐wide identification of mlo genes in the cultivated peanut (Arachis hypogaea L.) - Sy Mamadou Traore; Suoyi Han; Papias Binagwa; Wen Xu; Xiangyu Chen; Fengzhen Liu; Guohao He (Euphytica, 2021)
Powdery mildew disease caused by Oidium arachidis poses a threat to peanut production in Africa. Loss of function mutants of specific Mlo (Mildew Locus O) genes have provided broad-spectrum and durable resistance against pathogen in many crop species. Since there is huge potential to utilize susceptibility gene-mediated resistance in crop improvement, genome-wide mining of susceptibility genes is required for further researches. However, the susceptibility genes have not been characterized in peanut genome. In this research study, the genome of the cultivated peanut was used as reference to identify the AhMlo loci. Our results revealed that 25 AhMlo loci were identified and distributed on the chromosomes of the cultivated peanut. Eleven AhMlo loci were located on the A-genome while the remaining 14 on the B-genome. Variable number of inserted intron sequences (4–14) and transmembrane helix (4–8) were observed in the coding sequence of the AhMlo loci. Furthermore, phylogenetic analysis of the AhMlo loci along with homologs from other species has clustered the AhMlo loci into six clades. Three AhMlo loci were clustered in the clade V known to regroup the powdery susceptibility loci in dicots. Additionally, four core promoters were predicted on the promoter region of the specific AhMlo along with cis -regulatory elements related to PM susceptibility. These results provided strong evidence of the identification and distribution of the Mlo loci in the cultivated peanut genome and the identified specific AhMlo loci can be used for loss of susceptibility study.

Backward transmission of COVID-19 from humans to animals may propagate reinfections and induce vaccine failure - Shanshan He; Jie Han; Eric Lichtfouse (Environmental Chemistry Letters, 2021)

Impacts of native vegetation on the hydraulic properties of the concentrated flows in bank gullies - Zheng-an Su; Zhou-yao He; Tao Zhou; Jun-jie Wang; Xiao-yi Wang; Li-juan Wang; Hai-dong Fang; Liang-tao Shi; Yi-han Liu; Zuo Wu (Journal of Mountain Science, 2021)

Soil bacterial community composition and diversity respond to soil environment in the Ebinur Lake Wetland - Shuaibing He; Wenge Hu; Xitong Jin; Jing Han (Archives of Microbiology, 2021)

EmhR is an indole‐sensing transcriptional regulator responsible for the indole‐induced antibiotic tolerance in Pseudomonas fluorescens - Jian‐Ting Han; Di‐Yin Li; Meng‐Yuan Zhang; Xiao‐Quan Yu; Xiang‐Xue Jia; Hang Xu; Xu Yan; Wen‐Juan Jia; Shaomin Niu; Megan L. Kempher; Xuanyu Tao; Yong‐Xing He (Environmental Microbiology, 2021)
Summary Indole is well known as an interspecies signalling molecule to modulate bacterial physiology; however, it is not clear how the indole signal is perceived and responded to by plant growth promoting rhizobacteria (PGPR) in the rhizosphere. Here, we demonstrated that indole enhanced the antibiotic tolerance of Pseudomonas fluorescens 2P24, a PGPR well known for its biocontrol capacity. Proteomic analysis revealed that indole influenced the expression of multiple genes including the emhABC operon encoding a major multidrug efflux pump. The expression of emhABC was regulated by a TetR‐family transcription factor EmhR, which was demonstrated to be an indole‐responsive regulator. Molecular dynamics simulation showed that indole allosterically affected the distance between the two DNA‐recognizing helices within the EmhR dimer, leading to diminished EmhR–DNA interaction. It was further revealed the EmhR ortholog in Pseudomonas syringae was also responsible for indole‐induced antibiotic tolerance, suggesting this EmhR‐dependent, indole‐induced antibiotic tolerance is likely to be conserved among Pseudomonas species. Taken together, our results elucidated the molecular mechanism of indole‐induced antibiotic tolerance in Pseudomonas species and had important implications on how rhizobacteria sense and respond to indole in the rhizosphere.

Rare taxa maintain the stability of crop mycobiomes and ecosystem functions - Chao Xiong; Ji‐Zheng He; Brajesh K. Singh; Yong‐Guan Zhu; Jun‐Tao Wang; Pei‐Pei Li; Qin‐Bing Zhang; Li‐Li Han; Ju‐Pei Shen; An‐Hui Ge; Chuan‐Fa Wu; Li‐Mei Zhang (Environmental Microbiology, 2021)
Summary Plants harbour highly diverse mycobiomes which sustain essential functions for host health and productivity. However, ecological processes that govern the plant–mycobiome assembly, interactions and their impact on ecosystem functions remain poorly known. Here we characterized the ecological role and community assembly of both abundant and rare fungal taxa along the soil–plant continuums (rhizosphere, phyllosphere and endosphere) in the maize–wheat/barley rotation system under different fertilization practices at two contrasting sites. Our results indicate that mycobiome assembly is shaped predominantly by compartment niche and host species rather than by environmental factors. Moreover, crop‐associated fungal communities are dominated by few abundant taxa mainly belonging to Sordariomycetes and Dothideomycetes, while the majority of diversity within mycobiomes are represented by rare taxa. For plant compartments, the abundant sub‐community is mainly determined by stochastic processes. In contrast, the rare sub‐community is more sensitive to host selection and mainly governed by deterministic processes. Furthermore, our results demonstrate that rare taxa play an important role in fungal co‐occurrence network and ecosystem functioning like crop yield and soil enzyme activities. These results significantly advance our understanding of crop mycobiome assembly and highlight the key role of rare taxa in sustaining the stability of crop mycobiomes and ecosystem functions.

Diagnostic incremental value of sputum in patients with pleural tuberculosis - Shuai Guo; Chao Han; Yu He; Mao-Shui Wang (Infectious Diseases, 2021)

Characterization of a new gene for resistance to wheat powdery mildew on chromosome 1RL of wild rye Secale sylvestre - Huagang He; Haonan Du; Renkang Liu; Tianlei Liu; Lijun Yang; Shuangjun Gong; Zongxiang Tang; Haimei Du; Cheng Liu; Ran Han; Weihong Sun; Lei Wang; et al. (Theoretical and Applied Genetics, 2021)

Seismic wave equations in tight oil/gas sandstone media - Jinghuai Gao; Weimin Han; Yanbin He; Haixia Zhao; Hui Li; Yijie Zhang; Zongben Xu (Science China Earth Sciences, 2021)

Synthetic musk fragrances in sediments from a subtropical river-lake system in eastern China: occurrences, profiles, and ecological risks - Yang Lyu; Shan Ren; Fuyong Zhong; Xue Han; Ying He; Zhenwu Tang (Environmental Science and Pollution Research, 2021)

Polybrominated diphenyl ethers in soils from Tianjin, North China: distribution, health risk, and temporal trends - Yu Han; Jiali Cheng; Lei He; Minna Zhang; Shan Ren; Jiazheng Sun; Xiangyang Xing; Zhenwu Tang (Environmental Geochemistry and Health, 2021)

The critical curve for shallow saturated zone in soil slope under rainfall and its prediction for landslide characteristics - Jian He; Shuhong Wang; Huan Liu; Vantuan Nguyen; Wenshuai Han (Bulletin of Engineering Geology and the Environment, 2021)

A candidate PpRPH gene of the D locus controlling fruit acidity in peach - Lu Wang; Xiaohan Jiang; Li Zhao; Furong Wang; Yudi Liu; Hui Zhou; Huaping He; Yuepeng Han (Plant Molecular Biology, 2021)

Can the coronavirus disease be transmitted from food? A review of evidence, risks, policies and knowledge gaps - Jie Han; Xue Zhang; Shanshan He; Puqi Jia (Environmental Chemistry Letters, 2021)

Electrostatic fine particles emitted from laser printers as potential vectors for airborne transmission of COVID-19 - Shanshan He; Jie Han (Environmental Chemistry Letters, 2021)

Rhizobium rhizolycopersici sp. nov., Isolated from the Rhizosphere Soil of Tomato Plants in China - Kyu Kyu Thin; Shan-Wen He; Xing Wang; Yao Wang; Ma Rong; Ji-Gang Han; Xiaoxia Zhang (Current Microbiology, 2021)

Formation mechanism and risk assessment of unstable rock mass at the Yumenkou tunnel entrance, Shanxi province, China - Zhong Fu Wang; Si Ming He; Han Dong Liu; Dong Dong Li (Bulletin of Engineering Geology and the Environment, 2021)

Cerebral blood flow alterations in hemodialysis patients with and without restless legs syndrome: an arterial spin labeling study - Hao Wang; Xue Han; Mei Jin; Li-yan Wang; Zong-li Diao; Wang Guo; Peng Zhang; Zheng Wang; Han Lv; He-yu Ding; Zheng-yu Zhang; Peng-fei Zhao; et al. (Brain Imaging and Behavior, 2021)

Transcriptome reveals genes involving in black skin color formation of ducks - Lei Wang; Hehe Liu; Bo Hu; Jiwei Hu; Hengyong Xu; Hua He; Chunchun Han; Bo Kang; Lili Bai; Rongping Zhang; Jiwen Wang; Shengqiang Hu; et al. (Genes & Genomics, 2021)

Description and genomic characterization of Streptococcus symci sp. nov., isolated from a child’s oropharynx - He Qi; Defeng Liu; Yang Zou; Nan Wang; Han Tian; Chunling Xiao (Antonie van Leeuwenhoek, 2021)
Using the culturomics approach, we isolated a new Streptococcus species, strain C17 T , from the oropharynx mucosa sample of a healthy 5-year-old child living in Shenyang, China. We studied the phenotypic, phylogenetic, and genomic characteristics of strain C17 T , which was identified as a Gram-positive, coccus-shaped, non-motile, aerobic, catalase-negative bacteria. Its growth temperatures ranged from 20 to 42 °C, with optimal growth at 37 °C. Acid production could be inhibited by two sugars, trehalose and raffinose. In C17 T , the reactions for enzyme lipase (C14) were confirmed to be negative, whereas those for alkaline phosphatase, α-glucosidase, and hippuric acid hydrolysis were positive. The C17 T genome contained 2,189,419 base pairs (bp), with an average G+C content of 39.95%, encoding 2092 genes in total. The 16S ribosomal RNA sequence showed 99.8% similarity with the newly identified Streptococcus pseudopneumoniae ATCC BAA-960 T . The main fatty acid components in C17 T were C16:0, C18:1 w7c, C18:0, and C18:1 w9c, all of which can be found in other species of the Streptococcus genus. Strain C17 T showed high susceptibility to clindamycin, linezolid, vancomycin, chloramphenicol, and cefepime, and moderate susceptibility to erythromycin. The obtained dDDH value between strain C17 T and the closest species was 52.9%. In addition, the whole genome sequence of strain C17 T had an 82.21–93.40% average nucleotide identity (ANI) with those strains of closely related Streptococcus species, indicating that the strain C17 T was unique among all Streptococcus species. Based on these characteristics, we determine that C17 T is a novel species, named Streptococcus symci sp. nov. (= GDMCC 1.1633 = JCM 33582).

Rapid and highly efficient genomic engineering with a novel iEditing device for programming versatile extracellular electron transfer of electroactive bacteria - Yang‐Yang Fan; Qiang Tang; Yang Li; Feng‐He Li; Jing‐Hang Wu; Wen‐Wei Li; Han‐Qing Yu (Environmental Microbiology, 2021)
Summary The advances in synthetic biology bring exciting new opportunities to reprogram microorganisms with novel functionalities for environmental applications. For real‐world applications, a genetic tool that enables genetic engineering in a stably genomic inherited manner is greatly desired. In this work, we design a novel genetic device for rapid and efficient genome engineering based on the i ntron‐encoded homing‐endonuclease empowered genome editing (iEditing). The iEditing device enables rapid and efficient genome engineering in Shewanella oneidensis MR‐1, the representative strain of the electroactive bacteria group. Moreover, combining with the Red or RecET recombination system, the genome‐editing efficiency was greatly improved, up to approximately 100%. Significantly, the iEditing device itself is eliminated simultaneously when genome editing occurs, thereby requiring no follow‐up to remove the encoding system. Then, we develop a new extracellular electron transfer (EET) engineering strategy by programming the parallel EET systems to enhance versatile EET. The engineered strains exhibit sufficiently enhanced electron output and pollutant reduction ability. Furthermore, this device has demonstrated its great potential to be extended for genome editing in other important microbes. This work provides a useful and efficient tool for the rapid generation of synthetic microorganisms for various environmental applications.

Diversity and potential biogeochemical impacts of viruses in bulk and rhizosphere soils - Li Bi; Dan‐Ting Yu; Shuai Du; Li‐Mei Zhang; Li‐Yu Zhang; Chuan‐Fa Wu; Chao Xiong; Li‐Li Han; Ji‐Zheng He (Environmental Microbiology, 2021)
Summary Viruses can affect microbial dynamics, metabolism and biogeochemical cycles in aquatic ecosystems. However, viral diversity and functions in agricultural soils are poorly known, especially in the rhizosphere. We used virome analysis of eight rhizosphere and bulk soils to study viral diversity and potential biogeochemical impacts in an agro‐ecosystem. The order Caudovirales was the predominant viral type in agricultural soils, with Siphoviridae being the most abundant family. Phylogenetic analysis of the terminase large subunit of Caudovirales identified high viral diversity and three novel groups. Viral community composition differed significantly between bulk and rhizosphere soils. Soil pH was the main environmental driver of the viral community structure. Remarkably, abundant auxiliary carbohydrate‐active enzyme (CAZyme) genes were detected in viromes, including glycoside hydrolases, carbohydrate esterases and carbohydrate‐binding modules. These results demonstrate that virus‐encoded putative auxiliary metabolic genes or metabolic genes that may change bacterial metabolism and indirectly contribute to biogeochemical cycling, especially carbon cycling, in agricultural soil.

Abundance and distribution characteristics of microplastic in plateau cultivated land of Yunnan Province, China - Bin Huang; Leiye Sun; Mengran Liu; Haiyou Huang; Huan He; Fengxia Han; Xiaoxia Wang; Zhixiang Xu; Bei Li; Xuejun Pan (Environmental Science and Pollution Research, 2021)

The asymmetric impacts of ENSO modoki on boreal winter climate over the Pacific and its rim - Linqiang He; Xin Hao; Tingting Han (Climate Dynamics, 2021)

Comparison of the differences of sensible heat flux observation methods at different spatial scales in North China Plain - Xin Han; Baozhong Zhang; Qingyun Zhou; He Chen; Yinong Li; Zheng Wei; Taisheng Du (Arabian Journal of Geosciences, 2021)

Changes in reference evapotranspiration over the non‐monsoon region of China during 1961–2017: Relationships with atmospheric circulation and attributions - Yiyang Dong; Yong Zhao; Jiaqi Zhai; Jianshi Zhao; Jingyan Han; Qingming Wang; Guohua He; Huanyu Chang (International Journal of Climatology, 2021)
Reference evapotranspiration (ET 0 ) is an essential component of the hydrological cycle and is crucial to water resources management and assessment. Spatiotemporal variations in ET 0 and their attribution to five climatic variables (maximum and minimum air temperatures, solar radiation, vapour pressure, and wind speed) were estimated for the non‐monsoon region of China from 1961–2017 meteorological data by using the Penman–Monteith equation and the partial‐differential method. The association between ET 0 and atmospheric circulation patterns was explored by applying Pearson's correlation analysis. The annual ET 0 series had two earlier shift points, the first showing a significant increase from 1961 to 1973 (period I) and the second showing a significant decrease from 1974 to 1994 (period II). ET 0 has significantly increased again since 1994 (period III). Wind speed has been the dominant contributing factor to ET 0 followed by maximum air temperature during all three periods, but the contribution gap between minimum and maximum air temperatures is narrowing. ET 0 has been strongly correlated with eight selected teleconnection indices in some regions, but the locations and spatial extents have varied considerably for different indices. Eight relationships with ET 0 were divided into four groups: North Atlantic Oscillation and Arctic Oscillation (mainly the northwest non‐monsoon region), Pacific North American Index and Pacific Decadal Oscillation (mainly the northern non‐monsoon region), Antarctic Oscillation and Atlantic Multidecadal Oscillation (mainly the Hexi Corridor and the southern Xinjiang), and East Asian Summer Monsoon Index and South China Sea Summer Monsoon Index (mainly the southeast non‐monsoon region). The Antarctic Oscillation, Atlantic Multidecadal Oscillation, and South China Sea Summer Monsoon Index indicated more potential for predicting ET 0 . When we used Pearson's correlation analysis to analyse the relationship between atmospheric circulation and the dominant factors affecting ET 0 , we found that the circulation patterns are likely to affect the variation in ET 0 by influencing the dominant climatic variables.

Isolation and characterization of two new chroman-4-ones from the endophytic fungus Penicillium chrysogenum obtained from Eucommia ulmoides Oliver - Sheng-Yue Liu; Li-Zhi Wang; Yue-Fei Wang; Lin Li; Guo-Ying Han; Bing-Yang Zhang; Ying Guo; Yong-Zhi He; Shi-Ming Fang; Han Zhang (Natural Product Research, 2020)

Transcriptomic analysis reveals somatic embryogenesis-associated signaling pathways and gene expression regulation in maize (Zea mays L.) - Meiqi Ding; Haixiao Dong; Yingjie Xue; Shengzhong Su; Ying Wu; Shipeng Li; Hongkui Liu; He Li; Junyou Han; Xiaohui Shan; Yaping Yuan (Plant Molecular Biology, 2020)

Assessing SARS-CoV-2 RNA levels and lymphocyte/T cell counts in COVID-19 patients revealed initial immune status as a major determinant of disease severity - Mingfeng Han; Mengyuan Xu; Yafei Zhang; Zhongping Liu; Shasha Li; Tengfei He; Jinsong Li; Yong Gao; Wanjun Liu; Tuantuan Li; Zixiang Chen; Xin Huang; et al. (Medical Microbiology and Immunology, 2020)

The Effects of Different Fluorescent Indicators in Observing the Changes of the Mitochondrial Membrane Potential during Oxidative Stress-Induced Mitochondrial Injury of Cardiac H9c2 Cells - Yahan Sun; Kunyan Zhou; Mali He; Ying Gao; Danjie Zhang; Yanwen Bai; Yuezhao Lai; Mengying Liu; Xuechao Han; Sen Xu; Wei Tian; Jingman Xu (Journal of Fluorescence, 2020)

A predicted protein functional network aids in novel gene mining for characteristic secondary metabolites in tea plant (Camellia sinensis) - Shihua Zhang; Yong Ma; Rui Zhang; Xiaolong He; Ying Chen; Jingke Du; Chi-tang Ho; Youhua Zhang; Guomin Han; Xiaoyi Hu (Journal of Biosciences, 2020)

The Landscape of Micro-Inversions Provide Clues for Population Genetic Analysis of Humans - Li Qu; Luotong Wang; Feifei He; Yilun Han; Longshu Yang; May D. Wang; Huaiqiu Zhu (Interdisciplinary Sciences: Computational Life Sciences, 2020)
Background Variations in the human genome have been studied extensively. However, little is known about the role of micro-inversions (MIs), generally defined as small (< 100 bp) inversions, in human evolution, diversity, and health. Depicting the pattern of MIs among diverse populations is critical for interpreting human evolutionary history and obtaining insight into genetic diseases. Results In this paper, we explored the distribution of MIs in genomes from 26 human populations and 7 nonhuman primate genomes and analyzed the phylogenetic structure of the 26 human populations based on the MIs. We further investigated the functions of the MIs located within genes associated with human health. With hg19 as the reference genome, we detected 6968 MIs among the 1937 human samples and 24,476 MIs among the 7 nonhuman primate genomes. The analyses of MIs in human genomes showed that the MIs were rarely located in exonic regions. Nonhuman primates and human populations shared only 82 inverted alleles, and Africans had the most inverted alleles in common with nonhuman primates, which was consistent with the “Out of Africa” hypothesis. The clustering of MIs among the human populations also coincided with human migration history and ancestral lineages. Conclusions We propose that MIs are potential evolutionary markers for investigating population dynamics. Our results revealed the diversity of MIs in human populations and showed that they are essential to construct human population relationships and have a potential effect on human health.

Effects of juvenile crucian carp (Carassius carassius) removal on submerged macrophyte growth—implications for subtropical shallow lake restoration - Yanqing Han; Jiao Gu; Qisheng Li; You Zhang; Hu He; Ruijie Shen; Kuanyi Li (Environmental Science and Pollution Research, 2020)

Metagenomic Analysis Revealed that the Terrestrial Pollutants Override the Effects of Seasonal Variation on Microbiome in River Sediments - Han Qiu; Likun Gu; Bo Sun; Jianyun Zhang; Miao Zhang; Shanshan He; Shuqing An; Xin Leng (Bulletin of Environmental Contamination and Toxicology, 2020)

A Model to Estimate the Height of the Water-conducting Fracture Zone for Longwall Panels in Western China - Xiang He; Yixin Zhao; Cun Zhang; Penghua Han (Mine Water and the Environment, 2020)

Effects of Plant Diversity and Plant Density on Ecosystem Functions in Floating Constructed Wetlands - Wenjuan Han; Xiaoling Sheng; Jiongni Shao; Jia Jiang; Qinru He; Ying Lin (Water, Air, & Soil Pollution, 2020)

Applicability of cosmic-ray neutron sensor for measuring soil moisture at the agricultural-pastoral ecotone in northwest China - Xingyan Tan; Lanhui Zhang; Chansheng He; Yuzuo Zhu; Zhibo Han; Xuliang Li (Science China Earth Sciences, 2020)

The effect of blastomere loss during frozen embryo transfer on the transcriptome of offspring’s umbilical cord blood - Yan-Ting Wu; Ze-Han Dong; Cheng Li; Dai-Zhan Zhou; Jun-Yu Zhang; Yan Wu; Jing-Jing Xu; Yu Wang; Xiao-Qun Ye; Jian-Zhong Sheng; Li Wang; He-Feng Huang (Molecular Biology Reports, 2020)

Incidence of antibiotic resistance in Vibrio spp - Ke‐Yan Loo; Vengadesh Letchumanan; Jodi Woan‐Fei Law; Priyia Pusparajah; Bey‐Hing Goh; Nurul‐Syakima Ab Mutalib; Ya‐Wen He; Learn‐Han Lee (Reviews in Aquaculture, 2020)
Vibrio species is a common natural inhabitant of brackish and saltwater. Vibrio sp. includes not only emerging pathogens but also well‐known and emerged pathogens, such as V. cholerae , V. parahaemolyticus and V. vulnificus . Although it is often harmless, pathogenic strains which could cause serious food‐borne illnesses/outbreaks in both humans and animals have been identified. Vibrio infection is usually self‐limiting and requires no clinical treatment. However, antibiotics are still required to treat severe cases of Vibrio infection. Recent reports have highlighted a rise in the presence of antibiotic‐resistant Vibrio in the environment. This hampers the clinical treatment of Vibrio infection and has been linked to the imprudent use of antibiotics in various fields such as human medicine, agriculture and animal husbandry. As a result, it has greatly jeopardized food security, threatened public health and impugned the growth of economy. Food is a potential vehicle of antibiotic‐resistant Vibrio where the resistant genes are transmitted to humans via ingestion of contaminated food. Hence, the surveillance, monitoring and management of antibiotic patterns of Vibrio are important for clinical treatment. This review focuses on different trends and global patterns of antibiotic resistance of Vibrio .

Chemical constituents from Glehnia littoralis and their chemotaxonomic significance - Shouwen Zhang; Fang Cheng; Li Yang; Jinxiang Zeng; Fengyu Han; Xiuling Yu; Yuye Zhu; Guoyue Zhong; Junwei He (Natural Product Research, 2020)

Turning up the heat: warming influences plankton biomass and spring phenology in subtropical waters characterized by extensive fish omnivory - Hu He; Qisheng Li; Jing Li; Yanqing Han; Yu Cao; Wei Liu; Jinlei Yu; Kuanyi Li; Zhengwen Liu; Erik Jeppesen (Oecologia, 2020)

Evolution Mechanisms of Carbonate Reservoirs Based on Dissolution Rates and Multifractal Analysis of Microscopic Morphology - Jiayi Ma; Shuyun Xie; Huayun Tang; Ming Ma; Emmanuel John M. Carranza; Jun Han; Zhiliang He; Cunli Jiao; Hai Zhang (Natural Resources Research, 2020)

Transient receptor potential ankyrin 1 contributes to the ATP-elicited oxidative stress and inflammation in THP-1-derived macrophage - Chao Tian; Xiaobo Han; Lang He; Feng Tang; Rongqi Huang; Zuoxian Lin; Shuai Li; Sihao Deng; Junjie Xu; Hualin Huang; Huifang Zhao; Zhiyuan Li (Molecular and Cellular Biochemistry, 2020)

Impact of human activities on coastal groundwater pollution in the Yang-Dai River plain, northern China - Zekang He; Dongmei Han; Xianfang Song; Shengtian Yang (Environmental Science and Pollution Research, 2020)

Preparation and uranium (VI) biosorption for tri-amidoxime modified marine fungus material - Jingwen Han; Lin Hu; Leqing He; Kang Ji; Yaqing Liu; Can Chen; Xiaomei Luo; Ni Tan (Environmental Science and Pollution Research, 2020)

Molecular epidemiology of enteroviruses associated with severe hand, foot and mouth disease in Shenzhen, China, 2014-2018 - Long Chen; Shao-Jian Xu; Xiang-Jie Yao; Hong Yang; Hai-Long Zhang; Jun Meng; Han-Ri Zeng; Xu-He Huang; Ren-Li Zhang; Ya-Qing He (Archives of Virology, 2020)

Technological strategy and mobility of Middle Holocene hunter-gatherers in the high-altitude Qinghai-Tibetan Plateau: a case study from Tshem gzhung kha thog - Fang Han; Yuanhong He; Wei Du; Linghai Cai; Hongliang Lu (Archaeological and Anthropological Sciences, 2020)

Chemical characterization of constituents from Polygonatum cyrtonema Hua and their cytotoxic and antioxidant evaluation - Ting Zeng; Yan-Ran Tang; Bin Li; Shumaila Tasneem; Han-Wen Yuan; Yan-Zhe Jia; Muhammad Daniyal; Nusrat Hussain; Wen-Miao Wang; Da-Lei Zuo; Li-Min Gong; Bin Liu; et al. (Natural Product Research, 2020)

A Surface-to-Borehole TEM System Based on Grounded-wire Sources: Synthetic Modeling and Data Inversion - Weiying Chen; Sixu Han; Muhammad Younis Khan; Wen Chen; Yiming He; Linbo Zhang; Dongyang Hou; Guoqiang Xue (Pure and Applied Geophysics, 2020)

Genetic mapping and identification of new major loci for tolerance to low phosphorus stress in rice - Abdul Malik Solangi; Hira Khanzada; Ghulam Mustafa Wassan; Adnan Rasheed; Ayaz Ali Keerio; Majeeduddin Solangi; Saba Khanzada; Muhammad Faheem; Jianmin Bian; Xiaohua Pan; Rui Cai Han; Xunfeng He; et al. (Physiology and Molecular Biology of Plants, 2020)
Phosphorus (P) is one of the essential macronutrients for rice. In this study, we used 120 rice backcross recombinant inbred lines (BRILs) derived from a cross indica cv. Changhui 891 and japonica cv. 02428. To elucidate the genetic control of P deficiency tolerance in rice, we have used high quality SNPs bin markers to identify some important loci underlying phosphorus deficiency. The bin map was generated which includes 3057 bins covering distance of 1266.5 cM with an average of 0.41 cM between markers. Based on this map, 50 loci, including four novel loci, qSL - 3 , qRL - 11 , qSDW - 1 , qRDW - 1 with phenotypic variance 23.26%, 12.06%, 9.89% associated with P deficiency-related seedling traits were identified. No significant QTLs was found for root length under P+, shoot fresh weight P− and root length, shoot fresh weight for P+, P− and their ratio respectively. Root fresh weight, and root dry weight were strongly correlated to each other, and QTLs for these variables were located on the same chromosome 1 at the same region. Notably, 3 pleiotropic regions is the pioneer of our study, and these regions would facilitate map-based cloning to expedite the MAS selection for developing low phosphorous tolerant varieties. This study not only improves our knowledge about molecular processes associated with P deficiency, but also provides useful information to understand the genetic architecture of low phosphorous tolerance.

Mapping the susceptibility to landslides based on the deep belief network: a case study in Sichuan Province, China - Weidong Wang; Zhuolei He; Zheng Han; Yange Li; Jie Dou; Jianling Huang (Natural Hazards, 2020)

ISLR regulates skeletal muscle atrophy via IGF1-PI3K/Akt-Foxo signaling pathway - Can Cui; Shunshun Han; Xiaoxu Shen; Haorong He; Yuqi Chen; Jing Zhao; Yuanhang Wei; Yan Wang; Qing Zhu; Diyan Li; Huadong Yin (Cell and Tissue Research, 2020)

Identification and evaluation of tobacco cytoplasmic male sterile line Nta(gla)S K326 generated from asymmetric protoplast fusion of Nicotiana glauca and N. tabacum followed by backcrossing with N. tabacum K326 - Xue-Jun Chen; Zhi-Jun Tong; Bing-Guang Xiao; Yong-Ping Li; Fang-Chan Jiao; Yong Li; Tao Pang; Dun-Huang Fang; Xing-Fu Wu; Yi-Han Zhang; He Xie; Ge Bai; et al. (Plant Cell, Tissue and Organ Culture (PCTOC), 2020)

Occurrence of leaf spot caused by Nigrospora oryzae on red elephant grass in Chongqing, China - Yu-Zhu Han; Zi-wei Fan; Wei He; Jian Zhang (Journal of Plant Pathology, 2020)

Naphthalene exerts non-target effects on the abundance of active fungi by stimulating basidiomycete abundance - Li-ying Lan; Li Zhang; Ya Shen; Jian Zhang; Wan-qin Yang; Zhen-feng Xu; Yang Liu; Shu-qin He; Wei Zhou; Han Li; Li-xia Wang; Si-ning Liu; et al. (Journal of Mountain Science, 2020)

Anomalous distribution of distinctive water masses over the Carlsberg Ridge in May 2012 - Hailun He; Yuan Wang; Xiqiu Han; Yanzhou Wei; Pengfei Lin; Zhongyan Qiu; Yejian Wang (Ocean Science, 2020)
In May 2012, we conducted a hydrographic survey over the Carlsberg Ridge in the northwest Indian Ocean. In this paper, we use these station data, in combination with some free-floating Argo profiles, to obtain the sectional temperature and salinity fields, and subsequently, the hydrographic characteristics are comprehensively analyzed. Through the basic T–S diagram, three salty water masses, Arabian Sea High-Salinity Water, Persian Gulf Water, and Red Sea Water, are identified. The sectional data show a clear ventilation structure associated with Arabian Sea High-Salinity Water. The 35.8 psu salty water sinks at 6.9∘ N and extends southward to 4.4∘ N at depths around the thermocline, where the thermocline depth is in the range of 100 to 150 m. This salty thermocline extends much further south than climatology indicates. Furthermore, the temperature and salinity data are used to compute the absolute geostrophic current over the specific section, and the results show mesoscale eddy vertical structure different from some widely used oceanic reanalysis data. We also find a west-propagating planetary wave at 6∘ N, and the related features are described in terms of phase speed and horizontal and vertical structures.