A symbiosis between Euploea butterflies and yeasts - Wan-Rou Lin; Yi-Ping Chang; Hui-Lin Wu; I-Cheng Hsu; Pi-Han Wang (Symbiosis, 2023)

Selection and Verification of Reference Genes for Gene Expression Studies in Different Cell Lines of Golden Pompano (Trachinotus ovatus) - Na Zhao; Han Zhang; Lin Zhu; Yongwei Hou; Ying Wu; Zhenjie Cao; Yun Sun (Fishes, 2022)
The golden pompano snout (GPS) and head kidney (GPHK) cell lines have been proven to be meaningful tools for the study on pathogenic infections in vitro. In this study, we aimed to select the most stable reference genes from seven housekeeping genes (Actin, B2M, GAPDH, RPL13, EF1A, 18S and UBCE) applied to two cell lines of golden pompano (GPS and GPHK) under both normal physiological conditions and stimulated conditions of the lipopolysaccharide (LPS) or polyinosinic:polycytidylic acid (Poly I:C) relying on quantitative real-time PCR (qRT-PCR). Additionally, the raw Ct value resulting from the qRT-PCR was analyzed by the geNorm, NormFinder and BestKeeper algorithm, and the results indicated that expression for all candidate genes exhibited some discrepancy under different experimental conditions or cell types. As for the non-stimulated group, 18S and RPL13 were the most appropriate reference genes in GPS and GPHK cells, respectively. Nevertheless, the most suitable reference genes in GPS and GPHK cells, under the stimulation of LPS, were RPL13 and 18S, respectively, whereas after being stimulated with Poly I:C, UBCE and EF1A were recommended as the optimal candidates for GPS and GPHK cells, respectively. To be sure of the reliability of the selected reference genes, immune-related genes (ISG15, BCL2, IRF1 and IRF7) were chosen as target genes to normalize. The study will provide a direction for various golden pompano cell lines to screen appropriate reference genes, and will set the stage for the application of these cell lines in relevant research areas.

Control measure implications of COVID-19 infection in healthcare facilities reconsidered from human physiological and engineering aspects - Ying-Fei Yang; Yi-Jun Lin; Shu-Han You; Tien-Hsuan Lu; Chi-Yun Chen; Wei-Min Wang; Chung-Min Liao (Environmental Science and Pollution Research, 2022)

The biological transformation of ammonium and urea in a eutrophic estuarine system in Southern China - Jin-Ming Tang; Min Nina Xu; Yuxuan Lin; Huangxin Chen; Haoquan Jin; Li-Li Han; Wenbin Zou; Shuh-Ji Kao (Frontiers in Marine Science, 2022)
Estuaries channel large amounts of anthropogenic nitrogen (N) from continents to the offshore where productivity is widely limited by N and phosphorus. Ammonium and urea, two reduced forms of anthropogenic N commonly observed, are the preferred substrates for various microorganisms (e.g., uptake by phytoplankton or bacteria and oxidation by nitrifier). Yet, it remains underexplored how they transform and their concentrations vary during transport in the estuary which may influence the offshore microbial community. We applied 15 N isotope tracer incubation techniques to determine the two main bio-consumption processes, i.e., uptake and oxidation, of ammonium and urea, in the dark for the Jiulong River Estuary, a eutrophic estuary in southeastern China. Results showed that light penetration depth ranged from 0.8-3.3 m leaving 76% of estuary water bodies to stay in dark situations throughout a day. Ammonia oxidation, which favors dark conditions, dominates the estuarine regenerated-N cycle, showing the rank: ammonia oxidation > ammonium uptake >> urea uptake ≈ urea oxidation. By compiling the reported case studies, we found the relatively low ratio of urea oxidation to ammonia oxidation was accompanied by a relatively high ammonium concentration. Microorganisms’ high preference for ammonium over urea may lead to an inhibitory-like phenomenon. An analogous effect was evident by the increased urea uptake at downstream when ammonium was down to a few µM. The obstructed urea utilization resulted in 10 times longer lifetime for urea relative to ammonium (surface: 19 ± 9 days; bottom 12 ± 7 days). Such an inhibitory-like effect allows urea to be preserved in the estuary and allows urea to be transported farther offshore to stimulate microorganisms capable of utilizing urea, which may have significant impacts on offshore ecology.

Elastoplastic Modelling of Porous Limestones with Porosity Dependency - B. Han; Q. M. Gong; X. L. Du; Y. Gao; W. Q. Shen; S. Lin (Rock Mechanics and Rock Engineering, 2022)

Longitudinal Abnormalities in Brain Structure in COVID-19 Patients - Xiaoxing Liu; Wei Yan; Tangsheng Lu; Ying Han; Lin Lu (Neuroscience Bulletin, 2022)

Failure mode and genesis of bare dispersive soil slope in the cold dry region: insights from Southwest Songnen Plain, China - Yan Han; Qing Wang; Cencen Niu; Huicheng Fu; Jing Liu; Mengxia Han; Sen Lin; Muhammad Ammar (Bulletin of Engineering Geology and the Environment, 2022)

Research progress on intervention effect and mechanism of protocatechuic acid on nonalcoholic fatty liver disease - Yunxiao Gao; Rongrong Tian; Haiyue Liu; Huimin Xue; Ruizhe Zhang; Suping Han; Lin Ji; Weidong Huang; Jicheng Zhan; Yilin You (Critical Reviews in Food Science and Nutrition, 2022)

Numerical Investigation on Performance Optimization of Offshore Sandwich Blast Walls with Different Honeycomb Cores Subjected to Blast Loading - Hong Lin; Chang Han; Lei Yang; Lin Zhang; Haochen Luan; Pingping Han; Hao Xu; Shuo Zhang (Journal of Marine Science and Engineering, 2022)
As an important protective facility on offshore platform, the blast wall is of great significance in resisting oil and gas explosions. Honeycomb structures are widely used due to their unique deformation and mechanical properties under dynamic impact loads. The aim of this research is to develop an optimized design for an offshore sandwich blast wall with different honeycomb cores. The uniqueness of this paper is providing the quantitative optimization scheme for topological configurations and unit cell geometric parameters of honeycomb structures according to mass consistency and the proposed synthetic evaluation index of anti-blast performance. By using the numerical simulation software ANSYS/LS-DYNA, the CONWEP algorithm was first validated and then adopted to conduct the dynamical performance analysis of the honeycomb blast wall. For comparison purposes, simulating studies on a series of different blast walls were carried out by considering various influential parameters. According to different criteria, the blast resistance of the sandwich honeycomb structures was evaluated. It is found that the sandwich plate with concave arc honeycomb core has the best anti-blast performance compared to that of arrow honeycomb core and concave hexagonal honeycomb core. For the concave arc honeycomb structure, the geometric parameters such as concave angle and aspect ratio of honeycomb unit cell have great influence on the blast-resistance performance. Moreover, the concave arc honeycomb structure with positive gradient arrangement has better anti-blast performance than the negative one. The curved blast wall with the curvature of 1/20 achieves better anti-blast performance than the flat blast wall.

Feasibility Study of a Novel Open Ocean Aquaculture Ship Integrating with a Wind Turbine and an Internal Turret Mooring System - Hanyu Liu; Mingsheng Chen; Zhaolong Han; Hao Zhou; Lin Li (Journal of Marine Science and Engineering, 2022)
Marine aquaculture has been expanded into more remote areas due to the increasing demand for high value-added fish products, bringing more challenges in fuel supply and mooring safety to open ocean aquaculture farms. Therefore, the idea of integrating aquaculture farms with offshore renewable energy has attracted tremendous interest. This study proposes a novel open ocean aquaculture ship integrated with a NREL 5 MW wind turbine. In addition, an internal turret mooring system is installed at the bow of the aquaculture ship, making the wind turbine always face the wind blowing direction due to the weathervaning effect. In this study, a preliminary study of the dynamics and wind power generation of the proposed open ocean aquaculture ship was conducted. The aerodynamic and elastic effects of the wind turbine and the effect of nets under the wave and current behavior on the dynamics of the single-point moored aquaculture ship were investigated. Furthermore, the effects of the dynamics of the aquaculture ship on the power generation of the wind turbine were also studied to investigate the feasibility of the idea to integrate an aquaculture ship with a wind turbine.

Significant Wave Height Prediction in the South China Sea Based on the ConvLSTM Algorithm - Lei Han; Qiyan Ji; Xiaoyan Jia; Yu Liu; Guoqing Han; Xiayan Lin (Journal of Marine Science and Engineering, 2022)
Deep learning methods have excellent prospects for application in wave forecasting research. This study employed the convolutional LSTM (ConvLSTM) algorithm to predict the South China Sea (SCS) significant wave height (SWH). Three prediction models were established to investigate the influences of setting different parameters and using multiple training data on the forecasting effects. Compared with the SWH data from the China–France Ocean Satellite (CFOSAT), the SWH of WAVEWATCH III (WWIII) from the pacific islands ocean observing system are accurate enough to be used as training data for the ConvLSTM-based SWH prediction model. Model A was preliminarily established by only using the SWH from WWIII as the training data, and 20 sensitivity experiments were carried out to investigate the influences of different parameter settings on the forecasting effect of Model A. The experimental results showed that Model A has the best forecasting effect when using three years of training data and three hourly input data. With the same parameter settings as the best prediction performance Model A, Model B and C were also established by using more different training data. Model B used the wind shear velocity and SWH as training and input data. When making a 24-h SWH forecast, compared with Model A, the root mean square error (RMSE) of Model B is decreased by 17.6%, the correlation coefficient (CC) is increased by 2.90%, and the mean absolute percentage error (MAPE) is reduced by 12.2%. Model C used the SWH, wind shear velocity, wind and wave direction as training and input data. When making a 24-h SWH forecast, compared with Model A, the RMSE of Model C decreased by 19.0%, the CC increased by 2.65%, and the MAPE decreased by 14.8%. As the performance of the ConvLSTM-based prediction model mainly rely on the SWH training data. All the ConvLSTM-based prediction models show a greater RMSE in the nearshore area than that in the deep area of SCS and also show a greater RMSE during the period of typhoon transit than that without typhoon. Considering the wind shear velocity, wind, and wave direction also used as training data will improve the performance of SWH prediction.

Two new phenylpropenoid glycosides from the roots of Illicium dunnianum - Yi-lin Wang; Han Li; Ling Song; Yun-hang Gao; Teng-fei Chen (Natural Product Research, 2022)

Rose Bengal inhibits β-amyloid oligomers-induced tau hyperphosphorylation via acting on Akt and CDK5 kinases - Chen-Ye Mou; Yan-Fei Xie; Jia-Xin Wei; Qi-Yao Wang; Jing-Yang Le; Yong-Jie Bao; Pan-Pan Zhang; Yue-Chun Mao; Xing-Han Huang; Han-Bo Pan; C. Benjamin Naman; Lin Liu; et al. (Psychopharmacology, 2022)

Unique Pharmacology, Brain Dysfunction, and Therapeutic Advancements for Fentanyl Misuse and Abuse - Ying Han; Lu Cao; Kai Yuan; Jie Shi; Wei Yan; Lin Lu (Neuroscience Bulletin, 2022)

Inhibition of cGAS in Paraventricular Nucleus Attenuates Hypertensive Heart Injury Via Regulating Microglial Autophagy - Chengzhi Han; Xinyi Qian; Xiaorong Ren; Shutian Zhang; Li Hu; Jingyao Li; Yijun Huang; Renhui Huang; Kokwin Ooi; Hong Lin; Chunmei Xia (Molecular Neurobiology, 2022)

Optimized thyroid transcription factor-1 core promoter-driven microRNA-7 expression effectively inhibits the growth of human non-small-cell lung cancer cells - Shipeng Chen; Lian Guan; Xu Zhao; Jing Yang; Longqing Chen; Mengmeng Guo; Juanjuan Zhao; Chao Chen; Ya Zhou; Yong Han; Lin Xu (Journal of Zhejiang University-SCIENCE B, 2022)

PDGFD switches on stem cell endothelial commitment - Weisi Lu; Peipei Xu; Boxiong Deng; Jianing Zhang; Ying Zhan; Xianchai Lin; Xiangzhong Xu; Zhaoxia Xia; Xiaoxi Yang; Xiaoling Zeng; Lijuan Huang; Bingbing Xie; et al. (Angiogenesis, 2022)
The critical factors regulating stem cell endothelial commitment and renewal remain not well understood. Here, using loss- and gain-of-function assays together with bioinformatic analysis and multiple model systems, we show that PDGFD is an essential factor that switches on endothelial commitment of embryonic stem cells (ESCs). PDGFD genetic deletion or knockdown inhibits ESC differentiation into EC lineage and increases ESC self-renewal, and PDGFD overexpression activates ESC differentiation towards ECs. RNA sequencing reveals a critical requirement of PDGFD for the expression of vascular-differentiation related genes in ESCs. Importantly, PDGFD genetic deletion or knockdown increases ESC self-renewal and decreases blood vessel densities in both embryonic and neonatal mice and in teratomas. Mechanistically, we reveal that PDGFD fulfills this function via the MAPK/ERK pathway. Our findings provide new insight of PDGFD as a novel regulator of ESC fate determination, and suggest therapeutic implications of modulating PDGFD activity in stem cell therapy.

Nutrient distributions and nitrogen-anomaly (N*) in the tropical North Pacific Ocean - Aiqin Han; Yu Wang; Yunlong Huo; Cai Lin; Kaiwen Zhou; Fangfang Kuang; Hui Lin (Acta Oceanologica Sinica, 2022)

Evaluation of the Potential of the Hard Clam (Meretrix meretrix) Shell Which Can Be Used as the Bioindicator for Heavy Metal Accumulation - Yen-Ting Lin; Fang-Chi Chang; Ming-Tsung Chung; Ze-Kai Li; Chang-Chuan Chan; Ying-Sheng Huang; Kuo-Fang Huang; Yu-San Han (Fishes, 2022)
Clams, Meretrix meretrix, were one of the favorite aquatic products in Taiwan and the world. It was reported that the water pollutants such as heavy metals and chemicals might accumulate in the clam body and shell through filter-feeding behavior. Thus, the bivalves could be used as bioindicators in the aquatic environment. The present study analyzed 20 trace elements, Mg, Sr, Li, Cd, Ba, Mn, Al, U, Ti, Pb, Nd, B, S, Zn, Fe, P, Na, K, Cu, and Ni, in the shells of the clams collected from the wild coastal area and cultured ponds to evaluate which elements have the potential to be biomarkers. The concentrations of 20 elements were detected by Solution-Based Inductively Coupled Plasma Mass Spectrometry (SB-ICPMS). Among them, Cd, Al, U, Ti, Nd, S, and K were below the detection limit. The remaining elements were analyzed for accumulation. The levels of Zn, Fe, and Ni possess high variation in an identical environment; so, a PCA was conducted without these three elements to reduce noise. The PCA result proved that the clam could absorb specific trace elements from the habitat. After a period of time, the contents of the absorption in the shells of the clams living in an identical environment became more similar. The analyzed element, Pb, was not found with a special difference in this study. The levels of Na, Sr, Mg, B, Mn, P, Ba, Li, and Cu reflected different sampling sites, which suggested that these elements in the species M. meretrix had the potential to be used as biomarkers for assessing heavy metal accumulation in the environment.

The influence of climate change on the allocation efficiency of new and tradition energy - Kuei-Ying Huang; Yung-ho Chiu; Tzu-Han Chang; Tai-Yu Lin (Environmental Science and Pollution Research, 2022)

New phenolic glycosides from Anemone chinensis Bunge and their antioxidant activity - Zeng-Guang Zhang; Yuan-Yuan Li; Bin Lin; Pei-Pei Guan; Yu Mu; Wen-Jun Qiao; Jing-Sheng Zhang; Xue-Shi Huang; Li Han (Natural Product Research, 2022)

Transcriptome and metabolome profiling of interspecific CSSLs reveals general and specific mechanisms of drought resistance in cotton - Bei Han; Fengjiao Wang; Zhilin Liu; Lin Chen; Dandan Yue; Weinan Sun; Zhongxu Lin; Xianlong Zhang; Xiaofeng Zhou; Xiyan Yang (Theoretical and Applied Genetics, 2022)

Construction of a core germplasm bank of upland cotton (Gossypium hirsutum L.) based on phenotype, genotype and favorable alleles - Peng Han; Xiaomin Tian; Ying Wang; Cong Huang; Yizan Ma; Xiaofeng Zhou; Yu Yu; Dawei Zhang; Haijiang Xu; Yang Cao; Bo Zhu; Zhenxiu Feng; et al. (Genetic Resources and Crop Evolution, 2022)

Reciprocal modulation between cigarette smoking and internet gaming disorder on participation coefficient within functional brain networks - Xianxin Qiu; Xu Han; Yao Wang; Weina Ding; Yawen Sun; Hao Lei; Yan Zhou; Fuchun Lin (Brain Imaging and Behavior, 2022)

Progress of Selenium Deficiency in the Pathogenesis of Arthropathies and Selenium Supplement for Their Treatment - Huan Deng; Haobiao Liu; Zhihao Yang; Miaoye Bao; Xue Lin; Jing Han; Chengjuan Qu (Biological Trace Element Research, 2022)

Streptococcus humanilactis sp.nov., isolated from healthy nursing mother's breast milk - Xiaoqing Guo; Fei Han; Lin Cong; Yu Li; Yue Wu; Chen Liu; Jingfang Yang; Risu Na; Wenjun Liu (Archives of Microbiology, 2022)

Three-dimensional characteristics of mesoscale eddies simulated by a regional model in the northwestern Pacific Ocean during 2000–2008 - Guijing Yang; Xiayan Lin; Guoqing Han; Yu Liu; Gengxin Chen; Jianhui Wang (Acta Oceanologica Sinica, 2022)

The differential impact of air pollutants on acute urticaria and chronic urticaria: a time series analysis - Jiawei Li; Guoqiang Song; Zhenzhen Mu; Xiaoou Lan; Fan Yang; Lin Li; Xiuping Han (Environmental Science and Pollution Research, 2022)

Physiological Recordings of the Cerebellum in Movement Disorders - Ami Kumar; Chih-Chun Lin; Sheng-Han Kuo; Ming-Kai Pan (The Cerebellum, 2022)
The cerebellum plays an important role in movement disorders, specifically in symptoms of ataxia, tremor, and dystonia. Understanding the physiological signals of the cerebellum contributes to insights into the pathophysiology of these movement disorders and holds promise in advancing therapeutic development. Non-invasive techniques such as electroencephalogram and magnetoencephalogram can record neural signals with high temporal resolution at the millisecond level, which is uniquely suitable to interrogate cerebellar physiology. These techniques have recently been implemented to study cerebellar physiology in healthy subjects as well as individuals with movement disorders. In the present review, we focus on the current understanding of cerebellar physiology using these techniques to study movement disorders.

Spatio-temporal analysis of east greenland polar front - Yu Liu; Jianhui Wang; Guoqing Han; Xiayan Lin; Guijing Yang; Qiyan Ji (Frontiers in Marine Science, 2022)
The East Greenland Polar Front (EGPF) is an important front with strong salinity and temperature gradients in the Nordic Seas. It is formed by the interaction between Arctic-origin and Atlantic-origin water. The variations of EGPF are closely linked with sea ice melting and heat content transport associated with North Atlantic water recirculation. For a three-dimensional (3D) daily analysis, we use the global ocean eddy resolution reanalysis product (GLORYS12V1) from 1993 to 2018 to calculate the salinity and temperature horizontal gradient in the upper ocean and obtain the spatiotemporal distribution and intensity characteristics of EGPF. After assessment, the thresholds of the salinity and temperature fronts are set to 0.04 psu/km and 0.09°C/km, respectively. Compared with satellite observations of sea ice concentration, a significant spatial relationship is observed between the main position of EGPF and the ice edge before the sea ice shrinks to the continental shelf sea area. Affected by the freshening of the Arctic-origin water due to the melting of the sea ice, the intensity and area of EGPF show significant seasonal variations. Against the background of global warming, the sea ice area presents an obvious decreasing trend in the Greenland Sea. The melting of sea ice increased annually every summer from 1998 to 2018. The heat content transport of the Atlantic-origin water has also increased in recent years. The 3D characteristics (intensity and volume) of EGPF as salinity and temperature fronts exhibit increasing trends.

Wheat genomic study for genetic improvement of traits in China - Jun Xiao; Bao Liu; Yingyin Yao; Zifeng Guo; Haiyan Jia; Lingrang Kong; Aimin Zhang; Wujun Ma; Zhongfu Ni; Shengbao Xu; Fei Lu; Yuannian Jiao; et al. (Science China Life Sciences, 2022)

Validity Analysis of the Morphological Identification of Three Highly Morphologically Similar Species Belonging to the Genus Niviventer (Rodentia: Muridae) - Yao-Yao Li; Hao-Tian Li; Jia-Wei Hao; Chen-Yi Zhang; Guan-Ze Liu; Xing-Han Lin; Xiao-Qing Sun; Guo-Chen Zang; Yu-Chun Li (Journal of Mammalian Evolution, 2022)

Uncertainty health risk assessment and regional control of drinking water: a case study of Hanyuan County, southwest mountainous area, China - Zhengjiang Lin; Ying Liu; Zhihui Cheng; Rui Zhao; Han Zhang (Environmental Science and Pollution Research, 2022)

Identification and QTL mapping of important agronomic traits based on rice short-wide grain CSSL-Z752 with restorer line Xihui 18 as background - Lin-Jun Cai; Han Yun; Xiao-Long Zhong; Dan Du; Xi-Man Peng; Ji-Chao Dai; Zhen-Lin Yang; Fang-Ming Zhao; Chang-Wei Zhang (Cereal Research Communications, 2022)

Dynamic Performance and Crashworthiness Assessment of Honeycomb Reinforced Tubular Pipe in the Jacket Platform under Ship Collision - Hong Lin; Chang Han; Lei Yang; Hassan Karampour; Haochen Luan; Pingping Han; Hao Xu; Shuo Zhang (Journal of Marine Science and Engineering, 2022)
The collision between the pipe legs of jacket platforms and bypassing ships is of great concern for the safety assessment of platforms. Honeycomb structures have been widely used owing to their unique deformation and mechanical properties under dynamic impact loads. In this paper, two typical honeycomb structures, namely hexagonal honeycomb and arrow honeycomb, were constructed for the impact protection of inclined pipe legs in jacket platforms, and the present study aimed to assess the dynamical performance and crushing resistance of the designed honeycomb reinforced structure under ship collision by using the numerical simulation software ANSYS/LS-DYNA. The dynamical performance of the honeycomb reinforced pipe leg was investigated considering various influential parameters, including the impact velocity and impact direction. The crashworthiness of the two types of honeycomb was evaluated and compared by different criteria, namely the maximum impact depth (δmax), specific energy absorption (SEA) and the proposed index offset sliding (OS). The results demonstrated that both the hexagonal honeycomb structure and the arrow honeycomb structure can reduce the damage of inclined pipe legs caused by ship collision, while the hexagonal honeycomb can provide the better anti-collision capacity, which can well reduce the offset sliding and better protect the pipe leg from ship collision.

Modeling and Dynamic Analysis of a Triple-Tagline Anti-Swing System for Marine Cranes in an Offshore Environment - Maokai Sun; Shenghai Wang; Guangdong Han; Lin An; Haiquan Chen; Yuqing Sun (Journal of Marine Science and Engineering, 2022)
Payload lifting is inefficient and high-risk under rough sea conditions. Thus, it is not easy to achieve precise assembly, and the swing payload is liable to collide with other structures on deck and cause damage. In this paper, to explore the complex dynamic characteristics of a triple-tagline anti-swing system (TTAS) for marine cranes in an offshore environment, an irregular wave model was first integrated into a dynamic system model of TTAS, and the TTAS for offshore payload lifting was simplified as a constrained-pendulum system with moving base excitations. Further, the dynamic system model was established by applying the methods in robotics. Meanwhile, the dynamic characteristics were simulated and analyzed using Matlab/Simulink. The simulation results show that the in-plane angle and out-of-plane angle of the payload can be effectively suppressed, and the range of the two-dimensional trajectory of the payload is greatly reduced. The research results provide a theoretical basis for optimizing the mechanical structures of TTAS or similar equipment.

PTEN-induced kinase 1 enhances the reparative effects of bone marrow mesenchymal stromal cells on mice with renal ischaemia/reperfusion-induced acute kidney injury - Chenyu Lin; Wen Chen; Yong Han; Yujie Sun; Xiaoqiong Zhao; Yuan Yue; Binyu Li; Wenmei Fan; Tao Zhang; Li Xiao (Human Cell, 2022)
Acute kidney injury (AKI) is a common severe acute syndrome caused by multiple factors and is characterized by a rapid decline in renal function during a short period. Bone marrow mesenchymal stromal cells (BMSCs) are effective in treating AKI. However, the mechanism of their beneficial effects remains unclear. PTEN-induced kinase 1 (PINK1) may play an important role in kidney tissue repair. In this study, we explored the effect of PINK1 overexpression on enhancing BMSC-mediated repair of AKI. In this study, ischaemia/reperfusion-induced AKI (IRI-AKI) in mice and a hypoxia-reoxygenation model in cells were established, and the indices were examined by pathology and immunology experiments. After ischaemia/reperfusion, PINK1 overexpression reduced apoptosis in injured kidney tissue cell, decreased T lymphocyte infiltration, increased macrophage infiltration, and alleviated the inflammatory response. PINK1 relieved the stress response of BMSCs and renal tubular epithelial cells (RTECs), reduced apoptosis, altered the release of inflammatory factors, and reduced the proliferation of peripheral blood mononuclear cells (PBMCs). In conclusion, BMSCs and RTECs undergo stress responses in response to hypoxia, inflammation and other conditions, and overexpressing PINK1 in BMSCs could enhance their ability to resist these stress reactions. Furthermore, PINK1 overexpression can regulate the distribution of immune cells and improve the inflammatory response. The regulation of mitochondrial autophagy during IRI-AKI maintains mitochondrial homeostasis and protects renal function. The results of this study provide new strategies and experimental evidence for BMSC-mediated repair of IRI-AKI.

First report of Sclerotinia sclerotiorum on Atractylodes lancea in China - Feng Han; Jing Huang; Maoxiang Lin; Xuhong Song (Journal of Plant Pathology, 2022)

Stachybotranes A–D, phenylspirodrimanes from the wetland fungus Stachybotrys chartarum with cytotoxic activities - Yan-Ru Bao; Han-Lin Feng; Xin-Sheng Yao (Natural Product Research, 2022)

Chromosomal mapping of a locus associated with adult-stage resistance to powdery mildew from Agropyron cristatum chromosome 6PL in wheat - Yida Lin; Shenghui Zhou; Xuezhong Liang; Baojin Guo; Bing Han; Haiming Han; Jingpeng Zhang; Yuqing Lu; Zhi Zhang; Xinming Yang; Xiuquan Li; Weihua Liu; et al. (Theoretical and Applied Genetics, 2022)

Correction to: Exosome-Derived lncRNA NEAT1 Exacerbates Sepsis-Associated Encephalopathy by Promoting Ferroptosis Through Regulating miR-9-5p/ TFRC and GOT1 Axis - Xue-biao Wei; Wen-qiang Jiang; Ju-hao Zeng; Lin-qiang Huang; Hong-guang Ding; Yuan-wen Jing; Yong-li Han; Yi-chen Li; Sheng-long Chen (Molecular Neurobiology, 2022)

Biomechanical Analysis of Mandibular Implant-Assisted Removable Partial Denture with Distal Extension - Yung-Chung Chen; Chi-Lun Lin; Chen-Han Yu; Hung-Chih Chang; Yang-Ming Lin; Jia-Wei Lin (Journal of Medical and Biological Engineering, 2022)

A short review of probabilistic slope stability analysis considering spatial variability of geomaterial parameters - Wengang Zhang; Xin Gu; Liang Han; Jiahao Wu; Zhiwei Xiao; Maoyi Liu; Lin Wang (Innovative Infrastructure Solutions, 2022)

Correction to: Higher sequestration of wheat versus maize crop carbon in soil under rotations - Zheng-Rong Kan; Shou-Wei Han; Wen-Xuan Liu; Xin Zhao; Rattan Lal; Hai-Lin Zhang (Environmental Chemistry Letters, 2022)

Assessing the effect of probiotics on tilapia lake virus‐infected tilapia: Transmission and immune response - Ying‐Fei Yang; Jidapa Yamkasem; Win Surachetpong; Yi‐Jun Lin; Shu‐Han You; Tien‐Hsuan Lu; Chi‐Yun Chen; Wei‐Min Wang; Chung‐Min Liao (Journal of Fish Diseases, 2022)
Probiotics have been used to alleviate disease transmission in aquaculture. However, there are limited studies on probiotic use in modulating tilapia lake virus (TiLV). We assessed commercially available probiotic supplements used in TiLV‐infected tilapia and performed mortality and cohabitation assays. We developed a mechanistic approach to predict dose–response interactions of probiotic effects on mortality and immune gene response. We used a susceptible–infected–mortality disease model to assess key epidemiological parameters such as transmission rate and basic reproduction number ( R 0 ) based on our viral load dynamic data. We found that the most marked benefits of probiotics are significantly associated with immune system enhancements (~30%) and reductions in disease transmission (~80%) and R 0 (~70%) in tilapia populations, resulting in a higher tolerance of farming densities (~400 fold) in aquaculture. These findings provide early insights as to how probiotic use‐related factors may influence TiLV transmission and the immune responses in TiLV‐infected tilapia. Our study facilitates understanding the mode of action of probiotics in disease containment and predicting better probiotic dosages in diet and supplements to achieve the optimal culturing conditions. Overall, our analysis assures that further study of rationally designed and targeted probiotics, or mechanistic modelling is warranted on the basis of promising early data of this approach.

Growth of non‐English‐language literature on biodiversity conservation - Shawan Chowdhury; Kristofer Gonzalez; M. Çisel Kemahlı Aytekin; Seung‐Yun Baek; Michał Bełcik; Sandro Bertolino; Sjoerd Duijns; Yuqing Han; Kerstin Jantke; Ryosuke Katayose; Mu‐Ming Lin; Elham Nourani; et al. (Conservation Biology, 2022)
English is widely recognized as the language of science, and English‐language publications (ELPs) are rapidly increasing. It is often assumed that the number of non‐ELPs is decreasing. This assumption contributes to the underuse of non‐ELPs in conservation science, practice, and policy, especially at the international level. However, the number of conservation articles published in different languages is poorly documented. Using local and international search systems, we searched for scientific articles on biodiversity conservation published from 1980 to 2018 in English and 15 non‐English languages. We compared the growth rate in publications across languages. In 12 of the 15 non‐English languages, published conservation articles significantly increased every year over the past 39 years, at a rate similar to English‐language articles. The other three languages showed contrasting results, depending on the search system. Since the 1990s, conservation science articles in most languages increased exponentially. The variation in the number of non‐English‐language articles identified among the search systems differed markedly (e.g., for simplified Chinese, 11,148 articles returned with local search system and 803 with Scopus). Google Scholar and local literature search systems returned the most articles for 11 and 4 non‐English languages, respectively. However, the proportion of peer‐reviewed conservation articles published in non‐English languages was highest in Scopus, followed by Web of Science and local search systems, and lowest in Google Scholar. About 20% of the sampled non‐English‐language articles provided no title or abstract in English; thus, in theory, they were undiscoverable with English keywords. Possible reasons for this include language barriers and the need to disseminate research in countries where English is not widely spoken. Given the known biases in statistical methods and study characteristics between English‐ and non‐English‐language studies, non‐English‐language articles will continue to play an important role in improving the understanding of biodiversity and its conservation.

Analysis of Influencing Factors of SST in Tropical West Indian Ocean Based on COBE Satellite Data - Chaoli Tang; Dewei Hao; Yuanyuan Wei; Fengmei Zhao; Han Lin; Xin Wu (Journal of Marine Science and Engineering, 2022)
The time-frequency domain analysis of the sea surface temperature (SST) in the tropical western Indian Ocean was conducted using wavelet analysis, cross wavelet transform (XWT), the Mann–Kendall (MK) test, and other methods based on COBE-SST data for the last 50 years (1974–2020). From the perspective of time-frequency combination, examining the data of precipitation, sea surface heat flux, total cloud cover, and long-wave radiation, helped contribute to exploring the periodic changes of SST. Moreover, the Western Hemisphere Warm Pool (WHWP) was selected to analyze the role of SST from 1974 to 2020. Present results have demonstrated that the SST in the western Indian Ocean was in a stage of rising, particularly in 1998. According to the fast Fourier transform of the filtered SST time series, the tropical western Indian Ocean SST has a short period of 3–6 years, a medium period of about 10 years, and a long period of 40 years. The SST in the tropical western Indian Ocean has a resonance period of 2–6 years with precipitation, a resonance period of 2–6 years with sea surface heat flux, a resonance period of 4–5 years with total cloud cover, and a resonance period of 2–5 years with long-wave radiation. Importantly, SST was negatively associated with precipitation, total cloud cover, and long-wave radiation, and positively for sea surface heat flux before 1997. Seasonal migration activities are significantly correlated with the WHWP and the tropical western Indian Ocean SST. The spatial lattice point correlation coefficient is generally from 0.6 to 0.9, and the inter-annual serial correlation value is more than 0.89. Furthermore, the two exist with a resonance period of 2–5 years.

Research of Intelligent Logistics and High-Quality Economy Development for Yangtze River Cold Chain Shipping Based on Carbon Neutrality - Ruiqi Xiao; Lin Pan; Hanbin Xiao; Han Xiao; Ze Zhu (Journal of Marine Science and Engineering, 2022)
The current status of intelligent logistics and cold chain shipping research is a hot topic worldwide. Meanwhile, the study of regional logistics and regional economy, shipping logistics and regional economic theory and application methods, and the empirical analysis of the correlation between the Yangtze River shipping and the Yangtze River shipping economy have attracted a lot of attention. This research has revealed that the Internet of Things of Yangtze River shipping has a great impact on the Yangtze River and the importance of inland river economic development. This study presents the empirical analysis on the correlation between shipping logistics and the inland river economy, starting from qualitative and quantitative aspects, and taking Yangtze River shipping as the representative. The proposed mathematical models and qualitative data analysis are made on the relevant effects of intelligent logistics and cold chain shipping on an inland river economy including its impact on the industrial layout, international trade, and urbanization. The research results provide administrative decisions or guidance values for the economic development of inland river ports in the Yangtze River.

Post-transcriptional control of bacterial nitrogen metabolism by regulatory noncoding RNAs - Yueyue Han; Chao Li; Yongliang Yan; Min Lin; Xiubin Ke; Yunhua Zhang; Yuhua Zhan (World Journal of Microbiology and Biotechnology, 2022)
Nitrogen metabolism is the most basic process of material and energy metabolism in living organisms, and processes involving the uptake and use of different nitrogen sources are usually tightly regulated at the transcriptional and post-transcriptional levels. Bacterial regulatory noncoding RNAs are novel post-transcriptional regulators that repress or activate the expression of target genes through complementarily pairing with target mRNAs; therefore, these noncoding RNAs play an important regulatory role in many physiological processes, such as bacterial substance metabolism and stress response. In recent years, a study found that noncoding RNAs play a vital role in the post-transcriptional regulation of nitrogen metabolism, which is currently a hot topic in the study of bacterial nitrogen metabolism regulation. In this review, we present an overview of recent advances that increase our understanding on the regulatory roles of bacterial noncoding RNAs and describe in detail how noncoding RNAs regulate biological nitrogen fixation and nitrogen metabolic engineering. Furthermore, our goal is to lay a theoretical foundation for better understanding the molecular mechanisms in bacteria that are involved in environmental adaptations and metabolically-engineered genetic modifications.

Diminished miR-374c-5p negatively regulates IL (interleukin)-6 in unexplained recurrent spontaneous abortion - Lin Zhao; Li Han; Guozhen Hei; Ran Wei; Zhen Zhang; Xiaoxiao Zhu; Qiang Guo; Chu Chu; Xiaoxiao Fu; Ke Xu; Xia Li (Journal of Molecular Medicine, 2022)

Cerebellar Oscillations in Familial and Sporadic Essential Tremor - Shi-Bing Wong; Yi-Mei Wang; Chih-Chun Lin; Scott Kun Geng; Nora Vanegas-Arroyave; Seth L. Pullman; Sheng-Han Kuo; Ming-Kai Pan (The Cerebellum, 2022)

Isoflurane and Sevoflurane Induce Cognitive Impairment in Neonatal Rats by Inhibiting Neural Stem Cell Development Through Microglial Activation, Neuroinflammation, and Suppression of VEGFR2 Signaling Pathway - Chunlong Zuo; Junmei Ma; Yizhao Pan; Dongxu Zheng; Chunjiang Chen; Naqi Ruan; Ying Su; Haihan Nan; Qingquan Lian; Han Lin (Neurotoxicity Research, 2022)
Inhaled anesthetics are known to induce neurotoxicity in the developing brains of rodents, although the mechanisms are not well understood. The aim of this study was to elucidate the molecular mechanisms underlying anesthetics-induced neurodevelopmental toxicity by VEGF receptor 2 (VEGFR2) through the interaction between microglia and neural stem cells (NSCs) in postnatal day 7 (P7) rats. Cognitive function of P7 rats exposed to isoflurane and sevoflurane were assessed using Morris Water Maze and T maze tests. We also evaluated the expression levels of NSC biomarkers (Nestin and Sox2), microglia biomarker (CD11b or or IBA1), pro-inflammatory cytokines (IL-6 and TNF-α), and VEGFR2 using western blotting and immunohistochemistry in the brains of control and anesthesia-treated rats. We found spatial learning and working memory was impaired 2 weeks after anesthetics exposure in rats. Isoflurane induced stronger and more prolonged neurotoxicity than sevoflurane. However, cognitive functions were recovered 6 weeks after anesthesia. Isoflurane and sevoflurane decreased the levels of Nestin, Sox2, and p-VEGFR2, activated microglia, decreased the number of NSCs and reduced neurogenesis and the proliferation of NSCs, and increased the levels of IL-6, TNF-α, and CD11b. Our results suggested that isoflurane and sevoflurane induced cognitive impairment in rats by inhibiting NSC development and neurogenesis via microglial activation, neuroinflammation, and suppression of VEGFR2 signaling pathway.

Building a predictive model to identify clinical indicators for COVID-19 using machine learning method - Xinlei Deng; Han Li; Xin Liao; Zhiqiang Qin; Fan Xu; Samantha Friedman; Gang Ma; Kun Ye; Shao Lin (Medical & Biological Engineering & Computing, 2022)

Evaluation of PET List Data-Driven Gated Motion Correction Technique Applied in Lung Tumors - Yi-Lun Chen; Bang-Hung Yang; I.-Ling Shih; Ko-Han Lin (Journal of Medical and Biological Engineering, 2022)

Toxic encephalopathy induced by radix Sophorae tonkinensis - Xue-Lin Li; Hao-Tian Zhao; Jinming Han; Zhong-Rui Yan; Hai-Yang Wang (Acta Neurologica Belgica, 2022)

Functional connections between bird eggshell stiffness and nest characteristics through risk of egg collision in nests - Chih‐Ming Hung; Shu‐Han Tsao; Pei‐Lin Chiang; Shang‐Ping Wu; Mao‐Ning Tuanmu; Jia‐Yang Juang (Ecology Letters, 2022)
Eggs and nests are two critical traits for the ecological success of birds. Their functional interactions, however, remain unclear. Here, we examined the functional connections between egg stiffness and nest attachment, site and structure for 1350 avian species. We revealed high eggshell stiffness for eggs in nests with a pensile attachment, located on non‐tree vegetation or having a domed shape, suggesting that birds produce stiffer eggs in response to higher egg‐collision risk in unstable or enclosed nests. Interdependence models suggested that the evolution of eggshell stiffness was more likely to be driven by than drive that of nest characters. Our results implied a trade‐off between investment in competing for established nesting niches and producing stiff eggs to explore novel niches with high collision risk, possibly mediated by predation or thermoregulation. This study highlights an overlooked connection between nests and eggshells that may have broadened the ecological niches of birds.

Cholesterol Accumulation in Livers of Indian Medaka, Oryzias dancena, Acclimated to Fresh Water and Seawater - Naveen Ranasinghe; Chia-Hao Lin; Tsung-Han Lee (Frontiers in Marine Science, 2022)
Sterol regulatory-element binding proteins (SREBPs), sirtuin (SIRT1), and liver X receptor α (LXRα) play important roles in regulating cholesterol metabolism in mammals. However, little is known about the relationship between cholesterol metabolism and SIRT1, LXRα, and SREBP-1 in fish. In addition, knowledge of the effects of salinity on hepatic cholesterol metabolism in euryhaline teleosts is fragmented. This study revealed that hepatic cholesterol content was significantly different between fresh water (FW)- and seawater (SW)-acclimated Indian medaka. Gene expression analysis indicated srebp-1 , lxrα , and sirt1 transcripts were not affected by changes in ambient salinity. However, SREBP-1, but not LXRα and SIRT1 protein expression, was significantly induced in the liver of FW-acclimated medaka. When SREBP-1 Vivo-MO inhibited SREBP-1 translation, hepatic cholesterol content was predominantly downregulated in FW- and SW-acclimated medaka. This is the first study to show that SREBP-1 is involved in cholesterol biosynthesis in fish. Furthermore, SREBP-1 knockdown had different effects on the expression of hmgcr and fdps , which encode the key enzymes involved in cholesterol biosynthesis. This study further enhances our knowledge of cholesterol metabolism in the livers of euryhaline teleosts during salinity acclimation.

Review of the formation and influencing factors of food-derived glycated lipids - Lipeng Han; Qingna Lin; Guoqin Liu; Dongxue Han; Li Niu (Critical Reviews in Food Science and Nutrition, 2022)

Trametes suaveolens-derived biochar loaded on nanoscale zero-valent iron particles for the adsorption and reduction of Cr(VI) - W.-D. Wang; H.-T. Ma; W. Lin; P. Sun; L.-K. Zhang; J.-H. Han (International Journal of Environmental Science and Technology, 2022)

An implementation framework of blockchain-based hazardous waste transfer management system - Guanghan Song; Yujie Lu; Haibo Feng; Han Lin; Yang Zheng (Environmental Science and Pollution Research, 2022)

Responses of photosynthesis, antioxidant enzymes, and related gene expression to nicosulfuron stress in sweet maize (Zea mays L.) - Zhen-Xing Wu; Ning-Wei Xu; Min Yang; Xiang-Ling Li; Jin-Ling Han; Xiao-Hu Lin; Qing Yang; Gui-Hua Lv; Jian Wang (Environmental Science and Pollution Research, 2022)

Probabilistic stability analysis of embankment slopes considering the spatial variability of soil properties and seismic randomness - Wen-gang Zhang; Jia-hao Wu; Xin Gu; Liang Han; Lin Wang (Journal of Mountain Science, 2022)

Pinirhizobacter soli gen. nov., sp. nov., a novel low temperature resistant gammaproteobacterium in the family Rhodanobacteraceae isolated from rhizospheric soil of Larix gmelinii - Han Xue; Chun-gen Piao; Ying-hua Lin; Yong Li (Archives of Microbiology, 2022)

Hypothermal Effects on Energy Supply for Ionocytes in Gills of Freshwater- and Seawater-Acclimated Milkfish, Chanos chanos - Chia-Hao Chang; Chia-Jui Liu; Wei-Jie Lu; Li-Yang Wu; Kuang-Jie Lai; Yu-Ting Lin; Tsung-Han Lee (Frontiers in Marine Science, 2022)
The milkfish, Chanos chanos , is an important aquaculture species that can be cultured in freshwater (FW) and seawater (SW) ponds because of its high euryhalinity. In winter, cold snap leading to high mortality of this tropical species is a critical issue for the aquaculture industry in Taiwan. Under hypothermal stress, however, changes in energy supply for osmoregulation of this euryhaline species is intriguing. In this study, we used an antibody against glycogen phosphorylase (GP) to identify glycogen-rich (GR) cells distributed adjacent to the mitochondria-rich (MR) ionocytes in milkfish gills. Glucose transporter 1 (GLUT1), which plays a major role in energy supply, was also identified and localized in GR cells. Moreover, the expression of indicators of aerobic metabolism and energy production, citrate synthase (CS) and cytochrome c oxidase (COX), were analyzed in gills of FW- and SW-acclimated milkfish to reveal different strategies of energy utilization under hypothermal stress. When exposed to a low-temperature environment, SW individuals used branchial glycogen and lactate to match the energy demands of aerobic metabolism in ionocytes, and elevated aerobic capacity to support and maintain normal functions in gills. However, branchial glycogen mainly localized in the GR cells of FW milkfish was not utilized under hypothermal stress. Meanwhile, a similar level of branchial COX activity and COXIV protein abundance at low temperatures between FW and SW milkfish indicated similar energy requirements in gills. This suggested that another source, but not branchial glycogen, maintained the energy demand in FW milkfish. The present study illustrated differential energy supply strategies in gills between SW- and FW-acclimated milkfish for osmoregulation under low temperatures.

Differences of Macroalgal Consumption by Eight Herbivorous Coral Reef Fishes From the Xisha Islands, China - Peng Wu; Teng Wang; Yong Liu; Chunhou Li; Yayuan Xiao; Shannan Xu; Tingting Han; Lin Lin; Qiumei Quan (Frontiers in Marine Science, 2022)
Herbivorous fishes play an important role in preventing the overabundance of macroalgae on coral reefs. Understanding the feeding selectivity and consumption of macroalgae by herbivorous fishes can be challenging in studies of their ecological role in the preservation and recovery of coral reefs. Coral reef decline, macroalgal overgrowth and overfishing are clearly visible in the Xisha Islands, China. However, there are seldom studies on the feeding behaviors of herbivorous fishes in this area. We used microscopy, 18S rRNA high-throughput sequencing, and stable isotope analyses to comprehensively examine the diet of eight herbivorous reef fish species common in the Xisha Islands, including one parrotfish, two chub, two unicorn fish, and three rabbitfish. Based on microscopic examination, Siganus argenteus fed on the highest number of macroalgae species (five species), followed by Naso unicornis (four species). Kyphosus cinerascens , K. vaigiensis , N. unicornis and S. punctatissimus fed on the entire macroalgal thallus, indicating their greater ecological importance compared with species that only consume algal fronds. According to the 18S rRNA high-throughput sequencing of fish intestinal contents, cluster analysis revealed that consumed macroalgae composition from the eight fishes always grouped together based on the fish species, but with low similarity. K. vaigiensis removed the highest diversity of macroalgae species as well as the greatest quantity of macroalgae. Calotomus carolinus can consume the red alga Pneophyllum conicum , which is widely distributed on Indo-Pacific coral reefs and can overgrow and kill live corals. N. unicornis was found to occupy the lowest trophic position based on stable isotope analysis. Multi-technique analyses revealed that K. vaigiensis , N. unicornis and S. argenteus showed a high consumption potential of macroalgae, suggesting that they are the key browsers that should receive priority protection in the Xisha Islands. A diverse herbivorous fish fauna is also very important in the Xisha coral reefs. These results not only demonstrated the various functions of different herbivorous fish species in macroalgal removal, but also provided insights into the management of herbivorous fishes on the coral reefs of the South China Sea.

Seasonal Distributions of Methane in a Populous Urban Coastal Sea Area - Hsiao-Chun Tseng; Chia-Chia Lin; Hui-Juan Pan; Yokie Tai Yuh Han; Gwo-Ching Gong (Frontiers in Marine Science, 2022)
Methane (CH 4 ) is an important greenhouse gas, and its concentrations in aquatic areas are heavily influenced by anthropogenic activities, especially human-induced eutrophication, polluted river discharge and wastewater treatment plant (WWTP) effluents. Although coastal areas and estuaries contribute large amounts of global oceanic CH 4 emissions, the relative contributions of different sources have not been well determined. The Tamsui River located in northern Taiwan is an urban river flowing through populated cities and thus likely carries large amounts of contaminants, such as nutrients and organic matter to the estuary. In this study, we characterized the spatial distribution and seasonal variations in CH 4 in the Tamsui River estuary adjacent marine areas. The sea-to-air CH 4 fluxes were also estimated to quantify the strength of the study area as an atmospheric CH 4 source. Our results showed that CH 4 concentrations in coastal sea areas were influenced by WWTP effluents, sediment and freshwater inputs. Thus, river discharge and nutrient levels as well as strong vertical mixing and disturbances might increase CH 4 concentrations and emissions. The seasonal surface CH 4 concentrations and sea-to-air CH 4 fluxes were 13.7 ± 18.7 nM and 41.7 ± 68.0 μmol m -2 d -1 in autumn; 29.3 ± 19.8 nM and 61.3 ± 44.6 μmol m -2 d -1 in spring; 21.8 ± 13.9 nM and 37.0 ± 26.2 μmol m -2 d -1 in summer; and 27.0 ± 21.4 nM and 85.9 ± 75.4 μmol m -2 d -1 in winter.

Delayed rFGF21 Administration Improves Cerebrovascular Remodeling and White Matter Repair After Focal Stroke in Diabetic Mice - Yinghua Jiang; Jinrui Han; Yadan Li; Yinga Wu; Ning Liu; Samuel X. Shi; Li Lin; Jing Yuan; Shusheng Wang; Ming-Ming Ning; Aaron S. Dumont; Xiaoying Wang (Translational Stroke Research, 2022)

Characteristic Strength and Energy Evolution Law of Coal Treated by Ultrasonic Wave with Different Power Under Uniaxial Compression - Erhao Yang; Haifei Lin; Shugang Li; Pengxiang Zhao; Lei Qin; Ruizhe Wang; Shuangze Han (Natural Resources Research, 2022)

miR-183-5p promotes proliferation, invasion, and glycolysis of thyroid carcinoma cells by targeting FOXO1 - Chun Han; Kangnan Mo; Lin Jiang; Kejing Wang; Lisong Teng (Molecular and Cellular Biochemistry, 2022)

The significance of riparian communities in the energy flow of subtropical stream ecosystems - Yi-Chang Liao; An-Cheng Lin; Han-Ni Tsai; Yu-Ting Yen; Chyng-Shyan Tzeng; Man-Miao Yang; Hsing-Juh Lin (Aquatic Sciences, 2022)

One-Way Intestinal Perfusion of PVP/VA–Poloxamer 188–Curcuma longa L. Extract Solid Dispersion in Rats In Vivo and Its Effect on HSC–T6 Cell Proliferation - Jie Gao; Yi Shi; Yunfeng Han; Xi Tang; Ruohong Bi; Lin Pan; Xianrong Lai (AAPS PharmSciTech, 2022)

Exosome-Derived lncRNA NEAT1 Exacerbates Sepsis-Associated Encephalopathy by Promoting Ferroptosis Through Regulating miR-9-5p/TFRC and GOT1 Axis - Xue-biao Wei; Wen-qiang Jiang; Ju-hao Zeng; Lin-qiang Huang; Hong-guang Ding; Yuan-wen Jing; Yong-li Han; Yi-chen Li; Sheng-long Chen (Molecular Neurobiology, 2022)
Sepsis can cause sepsis-associated encephalopathy (SAE), but whether SAE was induced or exacerbated by ferroptosis remains unknown. In this study, the rat sepsis model was constructed using the cecal ligation and puncture method. The blood–brain barrier (BBB) permeability was measured by Evans blue dye (EBD) in vivo. The levels of ROS, Fe ion, MDA, GSH, and GPX4 were assessed by enzyme-linked immunosorbent assay (ELISA). The exosomes isolated from serum were cultured with bEnd.3 cells for the in vitro analysis. Moreover, bEnd.3 cells cultured with 100 μM FeCl3 (iron-rich) were to simulate ferroptosis stress. The cell viability was evaluated by Cell Counting Kit-8 (CCK-8) assay. A dual-luciferase reporter gene assay was performed to confirm the relationship between miR-9-5p with NEAT1, TFRC , and GOT1 . In vivo, it is found that BBB permeability was damaged in model rats. Level of ROS, Fe ion, and MDA was increased, and level of GSH and GPX4 was decreased, which means ferroptosis was induced by sepsis. Exosome-packaged NEAT1 in serum was significantly upregulated in model rats. In vitro, it is found that NEAT1 functions as a ceRNA for miR-9-5p to facilitate TFRC and GOT1 expression. Overexpression of NEAT1 enhanced ferroptosis stress in bEnd.3 cells. Increased miR-9-5p alleviated sepsis-induced ferroptosis by suppressing the expression of TFRC and GOT1 both in vivo and in vitro. In conclusion, these findings suggest that sepsis induced high expression of serous exosome-derived NEAT1, and it might exacerbate SAE by promoting ferroptosis through regulating miR-9-5p/ TFRC and GOT1 axis.

Efficient 2D multiple attenuation using SRME with curvelet-domain subtraction - Szu-Ying Lai; Yunung Nina Lin; Ho-Han Hsu (Marine Geophysical Research, 2022)
Surface Related Multiple Elimination (SRME) usually suffers the issue of either over-attenuation that damages the primaries or under-attenuation that leaves strong residual multiples. This dilemma happens commonly when SRME is combined with least-squares subtraction. Here we introduce a more sophisticated subtraction approach that facilitates better separation of multiples from primaries. Curvelet-domain subtraction transforms both the data and the multiple model into the curvelet domain, where different frequency bands (scales) and event directions (orientations) are represented by a finite number of curvelet coefficients. When combined with adaptive subtraction in the time–space domain, this method can handle model prediction errors to achieve effective subtraction. We demonstrate this method on two 2D surveys from the TAiwan Integrated GEodynamics Research (TAIGER) project. With a careful parameter determination flow, our result shows curvelet-domain subtraction outperforms least-squares subtraction in all geological settings. We also present one failed case where specific geological condition hinders proper multiple subtraction. We further demonstrate that even for data acquired with short cables, curvelet-domain subtraction can still provide better results than least-squares subtraction. We recommend this method as the standard processing flow for multi-channel seismic data.

Towards a rapid assessment of highway slope disasters by using multidisciplinary techniques - Meng-Chia Weng; Cheng-Han Lin; Wen-Jie Shiu; Wei-An Chao; Chia-Chi Chiu; Ching-Fang Lee; Wei-Kai Huang; Che-Ming Yang (Landslides, 2022)
Mega-earthquakes and extreme climate events accompanied by intrinsic fragile geology lead to numerous landslides along mountain highways in Taiwan, causing enormous life and economic losses. In this study, a system for rapid slope disaster information integration and assessment is proposed with the aim of providing information on landslide occurrence, failure mechanisms, and subsequent landslide-affected areas to the highway authority rapidly. The functionality of the proposed system is deployed into three units: (1) geohazard rapid report (GeoPORT I), (2) multidisciplinary geological survey report (GeoPORT II), and (3) site-specific landslide simulation report (GeoPORT III). After landslide occurrence, the seismology-based monitoring network rapidly provides the initial slope disaster information, including preliminary location, event magnitude, earthquake activity, and source dynamics, within an hour. Within 3 days of the landslide, a multidisciplinary geological survey is conducted to collect high-precision topographical, geological, and remote-sensing data to determine the possible failure mechanism. After integrating the aforementioned information, a full-scale three-dimensional landslide simulation based on the discrete element method is performed within 10 days to reveal the failure process and to identify the areas potentially affected by subsequent disasters through scenario modeling. Overall, the proposed system can promptly provide comprehensive and objective information to relevant authorities after the event occurrence for hazard assessment. The proposed system was validated using a landslide event in the Central Cross-Island Highway of Taiwan.

Correction to: Determination of interactions of ferrihydrite‑humic acid‑Pb (II) system - Zhuanjun Zhao; Liwei Yao; Jie Li; Xiangbang Ma; Liangwei Han; Zhiyuan Lin; Shuqi Guan (Environmental Science and Pollution Research, 2022)

Determination of interactions of ferrihydrite-humic acid-Pb (II) system - Zhuanjun Zhao; Liwei Yao; Jie Li; Xiangbang Ma; Liangwei Han; Zhiyuan Lin; Shuqi Guan (Environmental Science and Pollution Research, 2022)

Optimizing the distribution and proportion of various active sites for better NH3-SCR property over Cu/SSZ-13 - Ziqian Liu; Han Jiang; Bin Guan; Yanfei Wei; Xingze Wu; He Lin; Zhen Huang (Environmental Science and Pollution Research, 2022)

Distributions, origins, and health-risk assessment of nitrate in groundwater in typical alluvial-pluvial fans, North China Plain - Lin Gan; Guanxing Huang; Lixin Pei; Yanjing Gan; Chunyan Liu; Mingnan Yang; Dongya Han; Jiangmin Song (Environmental Science and Pollution Research, 2022)

Sphingobacterium bovistauri sp. nov., Isolated from the Faeces of Bos Taurus - Qiong Wang; Zhi-Qin Fang; Chen-Lu Zhang; Jian-Qiang Shen; Jian-Dong Lai; Xiu-Lin Han; Tao Lu (Current Microbiology, 2022)

Selenium Deficiency Leads to Changes in Renal Fibrosis Marker Proteins and Wnt/β-Catenin Signaling Pathway Components - Tingting Lin; Jiaqi Tao; Ying Chen; Yitong Zhang; Fenglan Li; Yutong Zhang; Xueqing Han; Zihui Zhao; Guiyan Liu; Hui Li (Biological Trace Element Research, 2022)

Consistency correction of echo intensity data for multiple radar systems and its application in quantitative estimation of typhoon precipitation - Shuai Zhang; Jing Han; Bingke Zhao; Zhigang Chu; Jie Tang; Limin Lin; Xiaoqin Lu; Jiaming Yan (Frontiers of Earth Science, 2022)

Spatiotemporal distribution and the passive dispersal of fungal spores through HVAC systems - Wan-Rou Lin; Yung-Hung Ho; Wai Kwan Lee; Hsuan-Min Cheng; Pi-Han Wang (Aerobiologia, 2022)

Prevalence, complete genome, and metabolic potentials of a phylogenetically novel cyanobacterial symbiont in the coral‐killing sponge, Terpios hoshinota - Yu‐Hsiang Chen; Hsing‐Ju Chen; Cheng‐Yu Yang; Jia‐Ho Shiu; Daphne Z. Hoh; Pei‐Wen Chiang; Wenhua Savanna Chow; Chaolun Allen Chen; Tin‐Han Shih; Szu‐Hsien Lin; Chi‐Ming Yang; James Davis Reimer; et al. (Environmental Microbiology, 2022)
Summary Terpios hoshinota is an aggressive, space‐competing sponge that kills various stony corals. Outbreaks of this species have led to intense damage to coral reefs in many locations. Here, the first large‐scale 16S rRNA gene survey across three oceans revealed that bacteria related to the taxa Prochloron , Endozoicomonas , SAR116, Ruegeria , and unclassified Proteobacteria were prevalent in T . hoshinota . A Prochloron ‐related bacterium was the most dominant and prevalent cyanobacterium in T . hoshinota . The complete genome of this uncultivated cyanobacterium and pigment analysis demonstrated that it has phycobiliproteins and lacks chlorophyll b , which is inconsistent with the definition of Prochloron . Furthermore, the cyanobacterium was phylogenetically distinct from Prochloron , strongly suggesting that it should be a sister taxon to Prochloron . Therefore, we proposed this symbiotic cyanobacterium as a novel species under the new genus Candidatus Paraprochloron terpiosi. Comparative genomic analyses revealed that ‘Paraprochloron’ and Prochloron exhibit distinct genomic features and DNA replication machinery. We also characterized the metabolic potentials of ‘Paraprochloron terpiosi’ in carbon and nitrogen cycling and propose a model for interactions between it and T. hoshinota . This study builds a foundation for the study of the T . hoshinota microbiome and paves the way for better understanding of ecosystems involving this coral‐killing sponge.

Propagation and Separation of Downslope Gravity Currents over Rigid and Emergent Vegetation Patches in Linearly Stratified Environments - Ying-Tien Lin; Yi-Qi Ye; Dong-Rui Han; Yu-Jia Chiu (Journal of Marine Science and Engineering, 2022)
Large eddy simulation (combined with the mixture model) and laboratory experiment were used to investigate the impact of emergent and rigid vegetation on the dynamics of downslope gravity currents in stratified environments. The reliability of the numerical model was assessed with the corresponding laboratory measurements. The results show that the vegetation cylinders lead to severe lateral non-uniformity of the current front, causing more evident lobe and cleft structures. In stratified environments, the smaller driving force leads to less propagating velocity until the current separates from the slope. The transition point (from acceleration to deceleration phases) of current velocity appears earlier as the vegetation becomes denser. The peak value of the bulk entrainment coefficient Ebuik is inversely proportional to the vegetation density, while the final converged value of Ebuik is proportional to the vegetation density. Vegetation patches make the degree of fluctuation of the instantaneous entrainment coefficient Einst more intense, and even negative values appear locally, indicating that the gravity current is detrained into the ambient fluid. The velocity profiles of gravity current develop multi-peak patterns in stratified environments due to fingering intrusive patterns. Our analysis reveals that as the vegetation density increases, the generated wakes behind vegetation cylinders increase local entrainment and mixing, causing the density of current flow from vegetation to decrease and reach the neutral buoyancy layer of ambient fluids earlier, finally leading to a smaller separation depth.

Effects of Suspended Particles on Exopolysaccharide Secretion of Two Microalgae in Jinjiang Estuary (Fujian, China) - Jie Liu; Xiaoyu Han; Hui Xing; Yiting Nan; Jiahui Lin; Junming He; Sijia Chen; Yanfang Wei; Peiyong Guo (Journal of Marine Science and Engineering, 2022)
The effects of suspended particles (SP) of different concentrations and sizes on the secretion of exopolysaccharide (EPS) by Chlorella pyrenoidosa (C. pyrenoidosa) and Microcystis flos-aquae (M. flos-aquae) in Jinjiang Estuary, Fujian Province, China were studied in co-cultures of microalgae and SP. The results show that the SP concentration has an “inhibit–promote–inhibit” effect on the secretion of EPS by C. pyrenoidosa, whereby there is an optimal concentration of SP corresponding to the largest amount of EPS secreted by C. pyrenoidosa. Low concentrations had no significant effect on the secretion of EPS from M. flos-aquae (p > 0.05), whereas higher concentrations had an inhibitory effect. The C. pyrenoidosa EPS content was found to be significantly decreased in response to SP of small particle sizes (0–75 and 75–120 μm) and significantly increased for SP of large particle sizes (120–150 and 150–500 μm). Small particle sizes (0–75 and 75–120 μm) were found to be beneficial to the secretion of EPS from M. flos-aquae, and the promotion of EPS secretion gradually decreased with the increase in SP particle size. However, when the particle size was too large (120–150 and 150–500 μm), SP had no significant effect on EPS secretion. This study is helpful for understanding the microalgae EPS secretion response to SP and provides a scientific basis for studying the mechanism of EPS secretion by algae and the effect of SP on eutrophication of the estuary.

CRISPR-Cas9-Mediated Gene Therapy in Neurological Disorders - Lihong Guan; Yawei Han; Ciqing Yang; Suxiang Lu; Jiang Du; Han Li; Juntang Lin (Molecular Neurobiology, 2022)

Ameliorating Effect of Umbilical Cord Mesenchymal Stem Cells in a Human Induced Pluripotent Stem Cell Model of Dravet Syndrome - Huifang Zhao; Shuai Li; Lang He; Feng Tang; Xiaobo Han; Weiyue Deng; Zuoxian Lin; Rongqi Huang; Zhiyuan Li (Molecular Neurobiology, 2022)

Video target detection of East Asian migratory locust based on the MOG2-YOLOv4 network - Zhao Bai; Zhan Tang; Lei Diao; Shuhan Lu; Xuchao Guo; Han Zhou; Chengqi Liu; Lin li (International Journal of Tropical Insect Science, 2022)

Trimetazidine affects pyroptosis by targeting GSDMD in myocardial ischemia/reperfusion injury - Xudong Chen; Shuang Lin; Shanshan Dai; Jibo Han; Peiren Shan; Weiqi Wang; Zhouqing Huang; Bozhi Ye; Weijian Huang (Inflammation Research, 2022)

Identification and bioinformatics analysis of differentially expressed milk exosomal microRNAs in milk exosomes of heat-stressed Holstein cows - Yue Wang; Jian Fang; Han-Fang Zeng; Ji-Feng Zhong; Hui-Xia Li; Kun-Lin Chen (Functional & Integrative Genomics, 2022)

Individual exposure to ambient PM2.5 and hospital admissions for COPD in 110 hospitals: a case-crossover study in Guangzhou, China - Jie-Qi Jin; Dong Han; Qi Tian; Zhao-Yue Chen; Yun-Shao Ye; Qiao-Xuan Lin; Chun-Quan Ou; Li Li (Environmental Science and Pollution Research, 2022)
Few studies have evaluated the short-term association between hospital admissions and individual exposure to ambient particulate matter (PM 2.5 ). Particularly, no studies focused on hospital admissions for chronic obstructive pulmonary disease (COPD) at the individual level. We assessed the short-term effects of PM 2.5 on hospitalization admissions for COPD in Guangzhou, China, during 2014–2015, based on satellite-derived estimates of ambient PM 2.5 concentrations at a 1-km resolution near the residential address as individual-level exposure for each patient. Around 40,002 patients with COPD admitted to 110 hospitals were included in this study. A time-stratified case-crossover design with conditional logistic regression models was applied to assess the effects of PM 2.5 based on a 1-km grid data of aerosol optical depth provided by the National Aeronautics and Space Administration on hospital admissions for COPD. Further, we performed stratified analyses by individual demographic characteristics and season of hospital admission. Around 10 μg/m 3 increase in individual-level PM 2.5 was associated with an increase of 1.6% (95% confidence interval [CI]: 0.6%, 2.7%) in hospitalization for COPD at a lag of 0–5 days. The impact of PM 2.5 on hospitalization for COPD was greater significantly in males and patients admitted in summer. Our study strengthened the evidence for the adverse effect of PM 2.5 based on satellite-based individual-level exposure data.

Higher sequestration of wheat versus maize crop carbon in soils under rotations - Zheng-Rong Kan; Shou-Wei Han; Wen-Xuan Liu; Xin Zhao; Rattan Lal; Hai-Lin Zhang (Environmental Chemistry Letters, 2022)

Current management of melanoma patients with nodal metastases - Dale Han; Alexander C. J. van Akkooi; Richard J. Straker; Adrienne B. Shannon; Giorgos C. Karakousis; Lin Wang; Kevin B. Kim; Douglas Reintgen (Clinical & Experimental Metastasis, 2022)

Synthesis of Silver- and Strontium-Substituted Hydroxyapatite with Combined Osteogenic and Antibacterial Activities - Yunfei Li; Wenying Wang; Jing Han; Zirui Li; Qiuxiang Wang; Xue Lin; Kun Ge; Guoqiang Zhou (Biological Trace Element Research, 2022)

The lining responses for shallow mountain tunnels subjected to frost heaving - Xian-zhang Ling; Yuan Yu; Liang Tang; Lin Geng; Xiao Han (Journal of Mountain Science, 2022)

Advenella mandrilli sp. nov., a bacterium isolated from the faeces of Mandrillus sphinx - Qiong Wang; Xiu-Lin Han; Zhi-Qin Fang; Chen-Lu Zhang; Chun Li; Tao Lu (Antonie van Leeuwenhoek, 2022)

Development and validation of a 30-day death nomogram in patients with spontaneous cerebral hemorrhage: a retrospective cohort study - Qian Han; Mei Li; Dongpo Su; Aijun Fu; Lin Li; Tong Chen (Acta Neurologica Belgica, 2022)

Research on hoop capacity of composite foundation of discarded rubber tires - Feng-Chi Wang; Jun Li; Zhen-Huan Lin; Pei-Pei Tian; Han-Yu Zhao (European Journal of Environmental and Civil Engineering, 2022)

miRNA–mRNA Integrative Analysis Reveals the Roles of miRNAs in Hypoxia-Altered Embryonic Development- and Sex Determination-Related Genes of Medaka Fish - Keng Po Lai; Nathan Yi Kan Tam; Yuelong Chen; Chi Tim Leung; Xiao Lin; Chau Fong Tsang; Yin Cheung Kwok; William Ka Fai Tse; Shuk Han Cheng; Ting Fung Chan; Richard Yuen Chong Kong (Frontiers in Marine Science, 2022)
Recent studies have shown hypoxia to be an endocrine disruptor that impairs sex differentiation and reproductive function, leading to male-biased F1 populations in fish. However, the molecular mechanisms through which hypoxia alters fish sex differentiation and therefore sex ratios remain poorly understood. In order to understand the potential role of miRNAs in mediating hypoxia-altered sex determination and differentiation in fish, we conducted small RNA sequencing and transcriptome sequencing on marine medaka ( Oryzias melastigma ) embryos that were exposed to hypoxia (2.0 ± 0.2 mg O 2 L – 1) for 40 h (encompassing a critical window of sex determination). We identified dysregulated miRNAs and mRNAs in the hypoxia-exposed embryo, and bioinformatic analysis of the integrative small RNA sequencing and transcriptome sequencing results revealed hypoxia to cause alterations of genes related to embryonic development through miRNA regulation. Importantly, we have identified miRNA-mRNA pairs that were reported to play roles in gonad development (novel miR-145-col9a3 and novel miRNA-94- arid5b), in sex hormone response (novel miRNA-210-ca2, novel miRNA-106-nr2f2, nbr-miR-29c-nr4a1, and ola-miR-92b-akr1d1), and in sex characteristic development (novel miRNA-145-mns1, nle-miR-20-sord, and ipu-miR-219b-abcc8). Our findings highlighted the possible roles of miRNA–mRNA in regulation of embryonic development and sex determination in response to hypoxic stress.

Dimeric hexylitaconic acids from the marine-derived fungus Aspergillus welwitschiae CUGBMF180262 - Jiahui Han; Na Yang; Shangzhu Wei; Jia Jia; Rui Lin; Jiangpeng Li; Hongkai Bi; Fuhang Song; Xiuli Xu (Natural Product Research, 2022)

Current Dependent Dispersal Characteristics of Japanese Glass Eel around Taiwan - Kuan-Mei Hsiung; Yen-Ting Lin; Yu-San Han (Journal of Marine Science and Engineering, 2022)
Japanese eel larvae are passively transported to the East Asian Continental Shelf by the North Equatorial Current, Kuroshio and Kuroshio intrusion currents, and coastal currents. Previous studies have investigated the dispersal characteristics and pathways of Japanese glass eels. However, there are still limitations in these studies. According to long-term (2010–2020) catch data from the Fisheries Agency in Taiwan, the distribution and time series of glass eels recruitment to Taiwan are closely related to the surrounding ocean currents. Recruitment begins in eastern Taiwan via the mainstream Kuroshio and in southern Taiwan via the Taiwan Strait Warm Current. In central Taiwan, recruitment occurs from southern Taiwan, as well as from mainland China via the southern branch of the China Coast Current (CCC). The latest recruitment occurred in northern Taiwan and mainly comprised glass eels from mainland China via the northern branch of the CCC. A stronger monsoon during the La Niña phase could affect the recruitment time series in northern and eastern Taiwan. This study suggests that the recruitment directionality of glass eels is an indicator of the flow field of ocean/coastal currents and elucidates the dispersal characteristics of glass eels in the waters around Taiwan.

Historical Connectivity and Demography of the Ferocious Reef Crab, Eriphia ferox (Crustacea; Eriphiidae), Demonstrate That Taoyuan Algal Reef Is an Essential Population Source Along the East Taiwan Strait - Mu-Han Chen; Ya-Yi Huang; Bi-Ying Huang; Hernyi Justin Hsieh; Jen Nie Lee; Mei Lin Neo; Hironobu Fukami; Chaolun Allen Chen (Frontiers in Marine Science, 2022)
The east Taiwan Strait is largely fringed by sandy and muddy habitats. However, a massive algal reef made of crustose coralline algae has been found along the coast off Taoyuan city in northwestern Taiwan. The porous structure of Taoyuan Algal Reef harbors high abundance and diversity in marine organisms, including the ferocious reef crab, Eriphia ferox . Such a pivotal geographic location and unique ecological features make Taoyuan Algal Reef a potential stepping stone connecting biotic reefs in the east Taiwan Strait, South China Sea to the south, and even the high latitude of Japan to the north. In this study, we examined the population connectivity and historical demography of E. ferox by analyzing mitochondrial cytochrome oxidase I (COI) fragments of 317 individuals sampled from 21 localities in the northwestern Pacific. Our analyses of haplotype network and pairwise F ST comparisons revealed a lack of phylogeographical structure among E. ferox populations, implying the existence of a migration corridor connecting the South and East China Seas through the east Taiwan Strait. Multiple lines of evidence, including significant values in neutrality tests, unimodally shaped mismatch distributions, and Bayesian skyline plots elucidated the rapid population growth of E. ferox following the sea-level rise after Last Glacial Maximum (ca. 2–10 Ka). Such demographic expansion in E. ferox coincided with the time when Taoyuan Algal Reef started to build up around 7,500 years ago. Coalescent migration analyses further indicated that the large and continuous E. ferox population exclusively found in Datan Algal Reef, the heart of Taoyuan Algal Reef, was a source population exporting migrants both northward and southward to the adjacent populations. The bidirectional gene flow should be attributed to larval dispersal by ocean currents and secondary contact due to historical population expansion. Instead of serving as a stepping stone, our results support that Taoyuan Algal Reef is an essential population source for biotic reef-associated species along the east Taiwan Strait, and highlight the importance of conserving such a unique ecosystem currently threatened by anthropogenic development.

Distinct durability of IgM/IgG antibody responses in COVID-19 patients with differing severity - Junyan Han; Ning Zhang; Danying Chen; Yuhuan Gong; Guoli Li; Yaxian Kong; Lin Pu; Chen Chen; Jingyuan Liu; Qi Wang; Ju Zhang; Xuesen Zhao; et al. (Science China Life Sciences, 2022)

Roles of interleukins in antibacterial immune defense of the brood pouch in the lined seahorse Hippocampus erectus - Han Jiang; Chunyan Li; Bo Zhang; Yongli Wu; Qiang Lin (Journal of Oceanology and Limnology, 2022)

Halomonas populi sp. nov. isolated from Populus euphratica - Lin Xu; Jun-Jie Ying; Yuan-Chun Fang; Ran Zhang; Jia Hua; Min Wu; Bing-Nan Han; Cong Sun (Archives of Microbiology, 2022)

The brown root rot fungus Phellinus noxius affects microbial communities in different root‐associated niches of Ficus trees - Tse‐Yen Liu; Chao‐Han Chen; Yu‐Liang Yang; Isheng J. Tsai; Ying‐Ning Ho; Chia‐Lin Chung (Environmental Microbiology, 2022)
Summary Brown root rot (BRR) caused by Phellinus noxius is a destructive tree disease in tropical and subtropical areas. To understand how BRR affects the composition of the plant rhizoplane‐enriched microbiota, the microbiomes within five root‐associated compartments (i.e., bulk soil, old/young root rhizosphere soil, old/young root tissue) of Ficus trees naturally infected by P. noxius were investigated. The level of P. noxius infection was determined by quantitative PCR. Illumina sequencing of the internal transcribed spacer and 16S rRNA revealed that P. noxius infection caused a significant reduction in fungal diversity in the bulk soil, the old root rhizosphere soil, and the old root tissue. Interestingly, Cosmospora was the only fungal genus positively correlated with P. noxius . The abundance and composition of dominant bacterial taxa such as Actinomadura , Bacillus , Rhodoplanes , and Streptomyces differed between BRR‐diseased and healthy samples. Furthermore, 838 isolates belonging to 26 fungal and 35 bacterial genera were isolated and tested for interactions with P. noxius . Antagonistic activities were observed for isolates of Bacillus , Pseudomonas , Aspergillus , Penicillium , and Trichoderma . Cellophane overlay and cellulose/lignin utilization assays suggested that Cosmospora could tolerate the secretions of P. noxius and that the degradation of lignin by P. noxius may create suitable conditions for Cosmorpora growth.

Kinetics and Size Effects on Adsorption of Cu(II), Cr(III), and Pb(II) Onto Polyethylene, Polypropylene, and Polyethylene Terephthalate Microplastic Particles - Xiaoxin Han; Shiyu Wang; Xue Yu; Rolf D. Vogt; Jianfeng Feng; Lifang Zhai; Weiqi Ma; Lin Zhu; Xueqiang Lu (Frontiers in Marine Science, 2021)
Due to its small size, large specific surface area and hydrophobicity, microplastics, and the adsorbed contaminants may together cause potential negative effects on ecosystems and human beings. In this study, kinetics and size effects on adsorption of Cu(II), Cr(III), and Pb(II) onto PE, PP and PET microplastic particles were explored. Results indicated that the PE and PET microplastics have the higher adsorption capacity for Cu(II), Cr(III), and Pb(II) than that for PP microplastic. The adsorption capacity was affected by microplastic types and metal species. Among the three metals, Pb(II) had the largest adsorption amount on microplastic particles, especially on PET particles. Moreover, the adsorption capacities of microplastics increase with the decrease of particle size. The metal adsorption capacity of <0.9 mm microplastics is greater than that of 0.9–2 mm and 2–5 mm microplastics. The size effect on metal adsorption was largest for PE microplastic. More attention should be paid in case of the coexistence of heavy metals and tiny PE and PET microplastics in the environment.

Sigma-1 Receptor Activation Suppresses Microglia M1 Polarization via Regulating Endoplasmic Reticulum–Mitochondria Contact and Mitochondrial Functions in Stress-Induced Hypertension Rats - Kokwin Ooi; Li Hu; Yi Feng; Chenzhi Han; Xiaorong Ren; Xinyi Qian; Haofeng Huang; Sijia Chen; Qi Shi; Hong Lin; Jijiang Wang; Danian Zhu; et al. (Molecular Neurobiology, 2021)

A Combined Remediation Strategy of Arsenic and Cadmium in the Paddy Soil of Polymetallic Mining Areas - Longyong Lin; Runliang Zhu; Zhaohui Li; Cunliang Han; Weiyu Li; Yirong Deng (Bulletin of Environmental Contamination and Toxicology, 2021)

Effect of lgals3a on embryo development of zebrafish - Kan Chen; Yuqi Fan; Jun Gu; Zhihua Han; Yue Wang; Lin Gao; Huasu Zeng; Chengyu Mao; Changqian Wang (Transgenic Research, 2021)

Correction to: 2021 Taxonomic update of phylum Negarnaviricota (Riboviria: Orthornavirae), including the large orders Bunyavirales and Mononegavirales - Jens H. Kuhn; Scott Adkins; Bernard R. Agwanda; Rim Al Kubrusli; Sergey V. Alkhovsky; Gaya K. Amarasinghe; Tatjana Avšič-Županc; María A. Ayllón; Justin Bahl; Anne Balkema-Buschmann; Matthew J. Ballinger; Christopher F. Basler; et al. (Archives of Virology, 2021)

Complete genome sequence of a putative novel ilarvirus isolated from Eleocharis dulcis - Lanqing Lv; Xinyang Wu; Jiajia Weng; Yuchao Lai; Kelei Han; Yuwen Lu; Jiejun Peng; Lin Lin; Shaofei Rao; Guanwei Wu; Jianping Chen; Hongying Zheng; et al. (Archives of Virology, 2021)

2021 Taxonomic update of phylum Negarnaviricota (Riboviria: Orthornavirae), including the large orders Bunyavirales and Mononegavirales - Jens H. Kuhn; Scott Adkins; Bernard R. Agwanda; Rim Al Kubrusli; Sergey V. Alkhovsky; Gaya K. Amarasinghe; Tatjana Avšič-Županc; María A. Ayllón; Justin Bahl; Anne Balkema-Buschmann; Matthew J. Ballinger; Christopher F. Basler; et al. (Archives of Virology, 2021)

Development of microsatellite markers for Diaphanosoma dubium (Crustacea, Cladocera) and application to seasonal population dynamics - Ping Liu; Shao-Lin Xu; Jian Liao; Henri J. Dumont; Bo-Ping Han (Aquatic Ecology, 2021)

Environmental contamination with SARS‐CoV ‐2 in COVID ‐19 hospitals in Wuhan, China, 2020 - Wei Liu; Dingchen Li; Chaojie Yang; Fangyan Chen; Ruizhong Jia; Leili Jia; Xinyi Xia; Shanhong Fan; Qing Tan; Yuehua Ke; Yong Chen; Haifeng Li; et al. (Environmental Microbiology, 2021)
Summary Coronavirus disease 2019 (COVID‐19) pandemic has caused high number of infections and deaths of healthcare workers globally. Distribution and possible transmission route of SARS‐CoV‐2 in hospital environment should be clarified. We herein collected 431 environmental (391 surface and 40 air) samples in the intensive care unit (ICU) and general wards (GWs) of three hospitals in Wuhan, China from February 21 to March 4, 2020, and detected SARS‐CoV‐2 RNA by real‐time quantitative PCR. The viral positive rate in the contaminated areas was 17.8% (28/157), whereas there was no virus detected in the clean areas. Higher positive rate (22/59, 37.3%) was found in ICU than that in GWs (3/63, 4.8%). The surfaces of computer keyboards and mouse in the ICU were the most contaminated (8/10, 80.0%), followed by the ground (6/9, 66.7%) and outer glove (2/5, 40.0%). From 17 air samples in the contaminated areas, only one sample collected at a distance of around 30 cm from the patient was positive. Enhanced surface disinfection and hand hygiene effectively decontaminated the virus from the environment. This finding might help understand the transmission route and contamination risk of SARS‐CoV‐2 and evaluate the effectiveness of infection prevention and control measures in healthcare facilities.

A New Instrumental Array in Sichuan, China, to Monitor Vibrations and Perturbations of the Lithosphere, Atmosphere, and Ionosphere - Chieh-Hung Chen; Yang-Yi Sun; Kai Lin; Chen Zhou; Rui Xu; Haiyin Qing; Yongxin Gao; Tao Chen; Fei Wang; Huaizhong Yu; Peng Han; Chi-Chia Tang; et al. (Surveys in Geophysics, 2021)

Fouling characteristics of cnidarians (Hydrozoa and Anthozoa) along the coast of China - Tao Yan; Mingqing Lin; Wenhao Cao; Shuaishuai Han; Xikun Song (Journal of Oceanology and Limnology, 2021)

Genome-wide evolution of MAPKs family and their expression in response to bacterial infection in seahorse Hippocampus erectus - Kai Wang; Xin Wang; Qiang Zou; Han Jiang; Rongrong Zhang; Yanan Tian; Lele Zhang; Qiang Lin (Journal of Oceanology and Limnology, 2021)

A 168-year temperature recording based on tree rings and latitude differences in temperature changes in northeast China - Yangao Jiang; Yuting Cao; Junhui Zhang; Zhuo Li; Guoqiang Shi; Shijie Han; Cassius E. O. Coombs; Chuan Liu; Xiaoguang Wang; Junwei Wang; Lin Hao; Qi Xu; et al. (International Journal of Biometeorology, 2021)

Spatial distributions and risk assessments of nutrients and heavy metalsin sediments from an impounded lake of China’s South-to-NorthWater Diversion Project - Baoying Wang; Jianyu Lin; Xiaogang Wu; Yinian Xue; Chao Han; Zhihong Zhang; Jinghua Ren; Qiushi Shen (Environmental Science and Pollution Research, 2021)

Ultraviolet photolysis of four typical cardiovascular drugs: mechanisms, influencing factors, degradation pathways, and toxicity trends - Senwen Ping; Wenting Lin; Anchen Liu; Zhihan Gao; Han Lin; Yuan Ren (Environmental Science and Pollution Research, 2021)

Identification of plant materials containing ephedrine alkaloids based on DNA barcoding and TaqMan real-time PCR assay - Yaqin Zheng; Han Gao; Ming Song; Yunhan Lin; Jiajia Fan; Yaqin Zhang; Xia Liu (Acta Physiologiae Plantarum, 2021)
An intentional or inadvertent mixing of plant materials containing ephedrine alkaloids, especially Ephedra , is illegal. In order to better detect plant materials containing ephedrine alkaloids in export and smuggling, DNA barcoding combined with a TaqMan real-time PCR-based assay were used in this study. We collected 201 samples from 18 species belonging to four genera distributed in three families to amplify two barcoding markers, internal transcribed spacer 2 (ITS2) and psb A -trn H. 175 ITS2 sequences and 136 psb A- trn H sequences were obtained. Alignments and the neighbor-joining tree indicated that ITS2 showed a better discrimination of species than psb A -trn H. In addition, based on the sequence comparison of the ITS2 region from 18 species, three sets of primer/probes were designed using the real-time PCR assay platform. A sensitivity test showed the above primer/probe sets were specific and sensitive (as little as 0.0050 ng/μL target DNA) to identify species containing ephedrine alkaloids. Hence, the combination of novel DNA barcoding and the TaqMan real-time PCR-based technique are promising tools for the identification of plant materials containing ephedrine alkaloids. It is beneficial to standardize market circulation and detection of plant materials containing ephedrine alkaloids.

Two new cephalochromin derivative from the Alternaria sp. ZG22 - Xin-Ming Song; Xue-Ming Zhou; Ya-Ling Li; Li-Bing Huang; Cai-Cui Chen; Yan Gao; Lin He; Xiao-qun Mao; Bing Chen; Jing-Wen Liu; Hui-Jie Liu; Xiao-Ping Song; et al. (Natural Product Research, 2021)

Dynamic Regulation of Ions and Amino Acids in Adult Asian Hard Clams Meretrix lusoria Upon Hyperosmotic Salinity - Chia-Hao Lin; Po-Ling Yeh; Yu-Chun Wang; Tsung-Han Lee (Frontiers in Marine Science, 2021)
The dynamic regulation of ions and amino acids in the gills and mantle of the Asian hard clam, Meretrix lusoria , following the exposure to a hyperosmotic environment was hitherto unclear. The present study revealed that the osmolality as well as the Na + and Cl – concentrations in the hemolymph were significantly increased 3 h after transferring the clams from an environment with the salinity of their natural habitat (brackish water; BW; 20‰) to one with hyperosmotic salinity (seawater; 35‰). In addition, we found that the specific activities of Na + /K + -ATPase, a key enzyme that plays a significant role in cell osmoregulation, in the gills and mantle of clams were significantly increased at 72 and 12 h post-transfer, respectively, during acclimation to hyperosmotic salinity. Similarly, the contents of free amino acids (FAAs) such as taurine, alanine, and glycine were significantly elevated during hyperosmotic salinity acclimation. Previous research indicates that taurine is the most abundant FAA in the gills and mantles of Asian hard clams and that the taurine transporter (TAUT) plays an important role in taurine accumulation. The present study showed that TAUT mRNA and protein expression were significantly and transiently increased in the mantle of Asian hard clams following exposure to seawater; although the expression of TAUT mRNA in the gills of Asian hard clams was also transiently stimulated by exposure to hyperosmotic salinity, the relative TAUT protein abundance decreased only at later stages. Accordingly, the findings of this study improve our understanding of the dynamic processes of ion and amino acid regulation in the peripheral tissues of bivalves under hyperosmotic stress.

Master regulator NtrC controls the utilization of alternative nitrogen sources in Pseudomonas stutzeri A1501 - Zhimin Yang; Qin Li; Yongliang Yan; Xiubin Ke; Yueyue Han; Shaoyu Wu; Fanyang Lv; Yahui Shao; Shanshan Jiang; Min Lin; Yunhua Zhang; Yuhua Zhan (World Journal of Microbiology and Biotechnology, 2021)
Pseudomonas stutzeri A1501 is a model strain used to study associative nitrogen fixation, and it possesses the nitrogen regulatory NtrC protein in the core genome. Nitrogen sources represent one of the important factors affecting the efficiency of biological nitrogen fixation in the natural environment. However, the regulation of NtrC during nitrogen metabolism in P. stutzeri A1501 has not been clarified. In this work, a phenotypic analysis of the ntrC mutant characterized the roles of NtrC in nitrogen metabolism and the oxidative stress response of P. stutzeri A1501. To systematically identify NtrC-controlled gene expression, RNA-seq was performed to further analyse the gene expression differences between the wild-type strain and the ∆ ntrC mutant under nitrogen fixation conditions. A total of 1431 genes were found to be significantly altered by ntrC deletion, among which 147 associative genes had NtrC-binding sites, and the pathways for nitrogen fixation regulation, nitrogenous compound acquisition and catabolism and nitrate assimilation were discussed. Furthermore, the oxidative stress-related gene ( katB ), which was upregulated by ntrC deletion, was suggested to be a potential target gene of NtrC, thus highlighting the importance of NtrC in nitrogenase protection against oxygen damage. Based on these findings, we propose that NtrC is a high-ranking element in the regulatory network of P. stutzeri A1501 that controls a variety of nitrogen metabolic and oxidative stress responsive traits required for adaptation to complex rhizosphere environments.

Complement C3 Aggravates Post-epileptic Neuronal Injury Via Activation of TRPV1 - Guang-Tong Jiang; Lin Shao; Shuo Kong; Meng-Liu Zeng; Jing-Jing Cheng; Tao-Xiang Chen; Song Han; Jun Yin; Wan-Hong Liu; Xiao-Hua He; Yu-Min Liu; Lanzi Gongga; et al. (Neuroscience Bulletin, 2021)

Chronic Exposure to Hypoxia Inhibits Myelinogenesis and Causes Motor Coordination Deficits in Adult Mice - Lin Chen; Shu-Yu Ren; Rui-Xue Li; Kun Liu; Jing-Fei Chen; Yu-Jian Yang; Yong-Bin Deng; Han-Zhi Wang; Lan Xiao; Feng Mei; Fei Wang (Neuroscience Bulletin, 2021)
Exposure to chronic hypoxia is considered to be a risk factor for deficits in brain function in adults, but the underlying mechanisms remain largely unknown. Since active myelinogenesis persists in the adult central nervous system, here we aimed to investigate the impact of chronic hypoxia on myelination and the related functional consequences in adult mice. Using a transgenic approach to label newly-generated myelin sheaths ( NG2-CreER TM ; Tau-mGFP ), we found that myelinogenesis was highly active in most brain regions, such as the motor cortex and corpus callosum. After exposure to hypoxia (10% oxygen) 12 h per day for 4 weeks, myelinogenesis was largely inhibited in the 4-month old brain and the mice displayed motor coordination deficits revealed by the beam-walking test. To determine the relationship between the inhibited myelination and functional impairment, we induced oligodendroglia-specific deletion of the transcription factor Olig2 by tamoxifen ( NG2-CreER TM ; Tau-mGFP; Olig2 fl/fl ) in adult mice to mimic the decreased myelinogenesis caused by hypoxia. The deletion of Olig2 inhibited myelinogenesis and consequently impaired motor coordination, suggesting that myelinogenesis is required for motor function in adult mice. To understand whether enhancing myelination could protect brain functions against hypoxia, we treated hypoxic mice with the myelination-enhancing drug-clemastine, which resulted in enhanced myelogenesis and improved motor coordination. Taken together, our data indicate that chronic hypoxia inhibits myelinogenesis and causes functional deficits in the brain and that enhancing myelinogenesis protects brain functions against hypoxia-related deficits.

Effect of dietary supplementation with Chlorella sorokiniana meal on the growth performance, antioxidant status, and immune response of rainbow trout (Oncorhynchus mykiss) - Weijun Chen; Lin Luo; Danxiang Han; Feiping Long; Qinglei Chi; Qiang Hu (Journal of Applied Phycology, 2021)

Spatial variation, water quality, and health risk assessment of trace elements in groundwater in Beijing and Shijiazhuang, North China Plain - Han Fang; Zhifen Lin; Xiaoli Fu (Environmental Science and Pollution Research, 2021)

Near-field prediction of chemical hazard diffusion based on improved differential evolution algorithm and fireworks algorithm - Chaoshuai Han; Xuezheng Zhu; Jin Gu; Qinwen Zuo; Lin Chen; Yihao Shi (Environmental Monitoring and Assessment, 2021)

Effects of emergent and submerged rigid vegetation configurations on gravity current dynamics - Dongrui Han; Jie Xiong; Xiaoyun Xie; Yingtien Lin (Environmental Fluid Mechanics, 2021)

Marinomonas vulgaris sp. nov., a marine bacterium isolated from seawater in a coastal intertidal zone of Zhoushan island - Jun-Jie Ying; Yuan-Chun Fang; Yong-Lian Ye; Zhi-Cheng Wu; Lin Xu; Bing-Nan Han; Cong Sun (Archives of Microbiology, 2021)

Stenotrophomonas strain CPCC 101271, an intestinal lifespan-prolonging bacterium for Caenorhabditis elegans that assists in host resistance to “Bacillus nematocida” colonization - Rui Han; Yu Wang; Yang Deng; Yuqin Zhang; Lin Zhang; Qiuhong Niu (Archives of Microbiology, 2021)
The soil-dwelling, opportunistic pathogenic bacterium "Bacillus nematocida" B16 exhibits strong killing activities against a variety of pathogenic nematodes via a “Trojan horse” mechanism that can kill worm species like Caenorhabditis elegans . The bacterial strain CPCC 101271 was previously isolated from the intestines of C. elegans that were recovered from natural habitats and can serve as a probiotic for C. elegans , while also assisting in resistance to infection by the pathogenic strain B16. In this study, the lifespan of C. elegans fed with strain CPCC 101271 cells was extended by approximately 40% compared with that of worms fed with Escherichia coli OP50 cells. In addition, the colonization of C. elegans by the pathogenic bacterium "B. nematocida" B16 was inhibited when pre-fed with strain CPCC 101271. Metagenomic sequence analysis of intestinal microbiota of C. elegans fed with strain CPCC 101271 and infected with B16 revealed that pre-feeding worms with CPCC 101271 improved the diversity of the intestinal bacteria. Moreover, community structure significantly varied in coordination with Stenotrophomonas spp. and Bacillus spp. abundances when competition between strains CPCC 101271 and B16 was evaluated. In conclusion, the nematode microbiota strain CPCC 101271 assisted in its host resistance to colonization by the pathogen "Bacillus nematocida" and can also promote life span-prolongation in C. elegans. These results underscore that understanding the interactions between C. elegans microbiota and pathogens can provide new insights into achieving effective biological control of agricultural pests.

Size Effect and Anisotropy in a Transversely Isotropic Rock Under Compressive Conditions - Kaihui Li; Zhen-Yu Yin; Dongya Han; Xiang Fan; Rihong Cao; Hang Lin (Rock Mechanics and Rock Engineering, 2021)

Descending Modulation of Spinal Itch Transmission by Primary Somatosensory Cortex - Zi-Han Wu; Han-Yu Shao; Yuan-Yuan Fu; Xiao-Bo Wu; De-Li Cao; Sheng-Xiang Yan; Wei-Lin Sha; Yong-Jing Gao; Zhi-Jun Zhang (Neuroscience Bulletin, 2021)

Integration of small RNAs, degradome, and transcriptome sequencing provides insights into the differences between Shizhu ginseng and Yuan ginseng - Mengyuan Peng; Yanlin Chen; Wenjuan Wang; Zhihua He; Wangqiang Dai; Zhiyun Lin; Zemin Yang; Mengjuan Gong; Yongqin Yin; Bin Han; Yu Zeng; Yingfang Wang (Journal of Plant Biochemistry and Biotechnology, 2021)
Panax ginseng is one of the most popular herbs which have been used as an important traditional Chinese medicine since ancient times. Yuan ginseng and Shizhu ginseng,which belong to P. ginseng , are widely used as substitutes for wild ginseng in clinical practice. Clinical practice has proved that the clinical efficacy of Shizhu ginseng is better than Yuan ginseng. However, current research cannot completely explain this phenomenon. Considering that small RNA may be one of the pharmacodynamic substances of P. ginseng , it is challenging to investigate differential miRNAs between Shizhu ginseng and Yuan ginseng. In this study, the transcriptome, small RNAome and degradome of P. ginseng were studied by high-throughput sequencing. A total of 63,875 unigenes and 43,950,137 small RNA clean reads were obtained from the roots of P. ginseng . Among 3206 differentially expressed genes, 1190 genes were up-regulated in Yuan ginseng when compared with Shizhu ginseng. 24 known differential miRNAs and 7 novel differential miRNAs were obtained. The 304 targets of 24 differentially expressed miRNA (17 known and 7 novel) families are mainly related to energy metabolism, biotic stress and disease immunity in ginseng itself. Through the association analysis of mRNA and miRNA, our work gives a better understanding of the difference between Yuan ginseng and Shizhu ginseng. Considering the cross-kingdom regulation of plant miRNAs, our results may provide a foundation for understanding the miRNA-dependent clinical efficacy in P. ginseng .

Differential DNA Methylation Profiles in Patients with Temporal Lobe Epilepsy and Hippocampal Sclerosis ILAE Type I - Wang Zhang; Haiyang Wang; Binchao Liu; Miaomiao Jiang; Yifei Gu; Shi Yan; Xian Han; Alicia Y. Hou; Chongyang Tang; Zhenfeng Jiang; Hong Shen; Meng Na; et al. (Journal of Molecular Neuroscience, 2021)

Characterization of Yields, Osmotic Stress-associated Traits, and Expression Patterns of ABA Receptor Genes in Winter Wheat Under Deficit Irrigation - Xinyang Bai; Liguo Guo; Ruize Lin; Le Han; Kai Xiao (International Journal of Plant Production, 2021)

Efficiently immobilizing uranium (VI) by oxidized carbon foam - Hongliang Bao; Chunyu Xie; Ling Han; Zenghui Yue; Yuan Qian; Linjuan Zhang; Zi-Jian Li; Huangjie Lu; Jian Lin; Jian-Qiang Wang (Environmental Science and Pollution Research, 2021)

Human Methylmercury Exposure and Potential Impacts in Central Tibet: Food and Traditional Tibetan Medicine - Menghan Cheng; Maodian Liu; Dou Li; Qing Luo; Zhihao Zhang; Liuliang Yuan; Chenghao Yu; Han Xie; Huiming Lin; Qianru Zhang; De Ji; Xuejun Wang (Bulletin of Environmental Contamination and Toxicology, 2021)

Seasonal variation of flavonoid metabolites in leaves of Liquidambar formosana ‘Nanlinhong’ trees revealed by UPLC-ESI–MS/MS - Jiu-Xin Lai; Fu-Rong Lin; Ping Huang; Wen-Ying Guo; Lie-Bao Han; Yong-Qi Zheng (Brazilian Journal of Botany, 2021)

Sphingobacterium rhinopitheci sp. Nov., isolated from the faeces of Rhinopithecus bieti in China - Xiu-Lin Han; Qiong Wang; Chen-Lu Zhang; Zhi-Qin Fang; Jian-Qiang Shen; Song Huang; Tao Lu (Archives of Microbiology, 2021)

The Significant Role of Radiosonde-measured Cloud-base Height in the Estimation of Cloud Radiative Forcing - Hui Xu; Jianping Guo; Jian Li; Lin Liu; Tianmeng Chen; Xiaoran Guo; Yanmin Lyu; Ding Wang; Yi Han; Qi Chen; Yong Zhang (Advances in Atmospheric Sciences, 2021)

Ethylene‐regulated leaf lifespan explains divergent responses of plant productivity to warming among three hydrologically different growing seasons - Haiyan Ren; Guodong Han; Mai‐He Li; Cuiping Gao; Lin Jiang (Global Change Biology, 2021)
Leaf senescence is known to be regulated by the plant hormone ethylene, but how leaf lifespan responds to global environmental change and links to ecosystem‐level responses remains largely unexplored. Here we investigated the effects of climate warming and nitrogen addition on plant functional traits, plant hormone ethylene and net primary production in a 13‐year field experiment in a desert steppe. Across the last 3 years of the experiment (2016–2018), plant productivity increased under warming only in 2016, when there was above normal precipitation, but consistently increased with nitrogen addition. Warming enhanced net photosynthesis, leaf nitrogen and ethylene production and reduced leaf lifespan in 2016 (a wet year), but not in 2017 (a drought year); the effect of warming in 2018 (a year with normal precipitation) was opposite to 2016, likely due to the below‐normal precipitation in the mid‐growing season in 2018. Nitrogen addition led to increases in leaf nitrogen, ethylene production and net photosynthesis, and declines in leaf lifespan in 2016 and 2018, but not in 2017. The ethylene‐regulated lifespan was further evidenced by the addition of CoCl 2 (an ethylene biosynthesis inhibitor) that reduced ethylene production and prolonged lifespan. Structural equation modeling showed that leaf lifespan had a negative effect on plant productivity, both directly and indirectly via its negative effect on net photosynthesis, across all 3 years. Our results demonstrate the divergent responses of leaf lifespan and, in turn, plant productivity to warming under inter‐annual and intra‐annual precipitation variation, thus linking plant hormone production, functional traits and ecosystem functioning in the face of global environmental change.

Interaction between the cell walls of microalgal host and fungal carbohydrate‐activate enzymes is essential for the pathogenic parasitism process - Juan Lin; Hailong Yan; Liang Zhao; Yanhua Li; Bahareh Nahidian; Mianmian Zhu; Qiang Hu; Danxiang Han (Environmental Microbiology, 2021)
Summary Fungi can parasitize microalgae, exerting profound impacts on both the aquatic ecosystems and microalgal mass cultures. In this study, the unicellular green alga Haematococcus pluvialis and the blastocladialean fungus Paraphysoderma sedebokerense were used as a model system to address the mechanisms underlying the fungal parasitism on the algal host. High‐throughput metabolic assay indicated that P . sedebokerense can utilize several carbon sources with a preference for mannose, glucose and their oligosaccharides, which was compatible with the profile of the host algal cell walls enriched with glucan and mannan. The results of dual transcriptomics analysis suggested that P . sedebokerense can upregulate a large number of putative carbohydrate‐activate enzymes (CAZymes) encoding genes, including those coding for the endo‐1,4‐β‐glucanase and endo‐1,4‐β‐mannanase during the infection process. The cell walls of H . pluvialis can be decomposed by both P . sedebokerense and commercial CAZymes (e.g. cellulase and endo‐1,4‐β‐mannanase) to produce mannooligomers, while several putative parasitism‐related genes of P . sedebokerense can be in turn upregulated by mannooligomers. In addition, the parasitism can be blocked by interfering the selected CAZymes including glucanase, mannanase and lysozyme with the specific inhibitors, which provided a framework for screening suitable compounds for pathogen mitigation in algal mass culture.

Overexpression of Cell-Surface Marker SLC16A1 Shortened Survival in Human High-Grade Gliomas - Hong-Han Lin; Wen-Chiuan Tsai; Chia-Kuang Tsai; Ssu-Han Chen; Li-Chun Huang; Dueng-Yuan Hueng; Kuang-Chen Hung (Journal of Molecular Neuroscience, 2021)

Recycle of synthetic calcium fluoride and waste sulfuric acid to produce electronic grade hydrofluoric acid - Min-Fa Lin; Jhong-Lin Wu; Ken-Lin Chang; Wen-Jhy Lee; Chih-Ping Chang; Yung-Chang Lin; Po-Han Chen (Environmental Science and Pollution Research, 2021)

Nanotechnology advances in pathogen- and host-targeted antiviral delivery: multipronged therapeutic intervention for pandemic control - Kai-Chieh Yang; Jung-Chen Lin; Hsiao-Han Tsai; Chung-Yao Hsu; Vicky Shih; Che-Ming Jack Hu (Drug Delivery and Translational Research, 2021)

Whole brain volume and cortical thickness abnormalities in Wilson’s disease: a clinical correlation study - Yukun Song; Lin Zou; Jing Zhao; Xiangxue Zhou; Yingqian Huang; Haishan Qiu; Haiwei Han; Zhiyun Yang; Xunhua Li; Xiaoying Tang; Jianping Chu (Brain Imaging and Behavior, 2021)

Disrupted white matter functional connectivity in aMCI APOEε4 carriers: a resting-state study - Hua Lin; Muwei Li; Yang Zhan; Li Lin; Kun Yang; Shimin Hu; Ying Han (Brain Imaging and Behavior, 2021)

Mild encephalitis/encephalopathy with a reversible splenial lesion associated with respiratory syncytial virus infection in infants - Xue-Lin Li; Jinming Han; Zhong-Rui Yan; Bing-Wei Zhang; Hai-Yang Wang (Journal of NeuroVirology, 2021)

Genetic changes and evolutionary analysis of canine circovirus - Lin Wang; Yifan li; Zhiyuan Guo; Ying Yi; Han Zhang; Haikun Shangguan; Chengshi Huang; Junwei Ge (Archives of Virology, 2021)

Porcine circovirus type 2 (PCV2) infection in Hebei Province from 2016 to 2019: a retrospective study - Lei Han; Guang-fu Yuan; Shao-jie Chen; Fei Dai; Lin-shan Hou; Jing-hui Fan; Yu-zhu Zuo (Archives of Virology, 2021)

Ammonia stress–induced apoptosis by p53–BAX/BCL-2 signal pathway in hepatopancreas of common carp (Cyprinus carpio) - Shuqun Xue; Jiawen Lin; Yue Han; Ying Han (Aquaculture International, 2021)

Effects of diethyl aminoethyl hexanoate on the physiology and selenium absorption of grape seedlings - Lei Liu; Jiaxi Han; Lili Deng; Huixuan Zhou; Yuhui Bie; Qianhe Jing; Lijin Lin; Jin Wang; Ming’an Liao (Acta Physiologiae Plantarum, 2021)

Identification of potential sex-related genes in Siniperca chuatsi - Qiaoying Zhu; Chong Han; Cheng Peng; Xingni Zhou; Chongwei Wang; Linqiang Han; Shuisheng Li; Guifeng Li; Haoran Lin; Yong Zhang (Journal of Oceanology and Limnology, 2021)

A luminescent Zn(II)-Containing Complex: Selective Sensing of Cr(VI) Anion and Application Values on Tuberculosis Care Through Increasing the Antibacterial Response of Macrophages - Jin-Chao Mao; Jin-Jing Hong; Ming-Zheng Lin; Feng Han; Dong Li (Journal of Fluorescence, 2021)

Quantitative Fluorescence Resonance Energy Transfer Analysis on the Direct Interaction of Activation-2b with Histone H3/Switch-3B Protein in Arabidopsis Mesophyll Protoplasts - Lu Gao; Fangrui Lin; Danlu Han; Jieming Jiang; Chengwei Yang; Zhengfei Zhuang; Tongsheng Chen (Journal of Fluorescence, 2021)

Distributions of Total Mercury and Methylmercury in Dragonflies from a Large, Abandoned Mercury Mining Region in China - Gaoen Wu; Shunlin Tang; Jialiang Han; Chan Li; Lin Liu; Xiaohang Xu; Zhidong Xu; Zhuo Chen; Yajie Wang; Guangle Qiu (Archives of Environmental Contamination and Toxicology, 2021)

Different posterior hippocampus and default mode network modulation in young APOE ε4 carriers: a functional connectome-informed phenotype longitudinal study - Li Juan Zheng; Li Lin; U. Joseph Schoepf; Akos Varga-Szemes; Rock H. Savage; Han Zhang; Yun Fei Wang; Xin Yuan Zhang; Song Luo; Ya Liu; Gui Fen Yang; Guang Ming Lu; et al. (Molecular Neurobiology, 2021)

Disrupted pathways from frontal-parietal cortex to basal ganglia and cerebellum in patients with unmedicated obsessive compulsive disorder as observed by whole-brain resting-state effective connectivity analysis – a small sample pilot study - Wei Liu; Minghui Hua; Jun Qin; Qiuju Tang; Yunyi Han; Hongjun Tian; Daxiang Lian; Zhengqing Zhang; Wenqiang Wang; Chunxiang Wang; Ce Chen; Deguo Jiang; et al. (Brain Imaging and Behavior, 2021)

Development of a TaqMan loop-mediated isothermal amplification assay for the rapid detection of pigeon paramyxovirus type 1 - Ruiying Liang; Lin Liang; Xiaoxia Ren; Yaxiong Jia; Kun Han; Jingjie Zhao; Cuiping Song; Shangjin Cui (Archives of Virology, 2021)

Germination dynamics of allergenic fungal spores in respiratory mucus - Wan-Rou Lin; Szu-Yu Chen; Shih-Ching Hsiao; Pi-Han Wang (Aerobiologia, 2021)

Kelp aquaculture in China: a retrospective and future prospects - Zi‐Min Hu; Ti‐Feng Shan; Jie Zhang; Quan‐Sheng Zhang; Alan T. Critchley; Han‐Gil Choi; Norishige Yotsukura; Fu‐Li Liu; De‐Lin Duan (Reviews in Aquaculture, 2021)
Globally, China has the largest scale of kelp cultivation and production operations. However, its kelp aquaculture industry is suffering from declining germplasm diversity, degradation of agronomic traits, the presence of polluted environments, changing ocean conditions and increasing anthropological interference. This review covers two of the most commercially important kelp species in China, viz. Saccharina japonica and Undaria pinnatifida . It summarizes the history of their cultivation, production, economic and ecological benefits, their breeding programmes (e.g. inter‐ and intra‐specific hybridization and marker‐assisted selection) and efforts towards population genetic diversity and conservation. The article focuses on three significant challenges, for example genetic cross‐contamination between the wild and farmed kelp populations, ocean warming and ocean acidification. Accordingly, we outline the steps required to provide several intervention measures, for example (i) collection and preservation of wild and cultivated kelp germplasm; (ii) selection of suitable cultivation sites under changing environmental conditions; (iii) developing stress‐resistant cultivars; and finally, (iv) adoption of innovative cultivation models. The review concludes with genome‐based, designs for molecular breeding and calls for the establishment of an East Asian Kelp Consortium (EAKC). Collectively, the Chinese kelp industry could provide beneficial goods and services, for example bioenergy to fine chemicals and environmental benefits, such as carbon capture, pH amelioration and provision of habitat for many other marine species of commercial value. The strategies proposed in this article thus have the potential to not only improve but also reinvigorate the kelp industry in China and nearby Japan and Korea, in the context of both environmental health and economic benefits.

Cover Image - Zi‐Min Hu; Ti‐Feng Shan; Jie Zhang; Quan‐Sheng Zhang; Alan T. Critchley; Han‐Gil Choi; Norishige Yotsukura; Fu‐Li Liu; De‐Lin Duan (Reviews in Aquaculture, 2021)
The cover image is based on the Review Article Kelp aquaculture in China: A retrospective and future prospects by Zi‐Min Hu et al., https://doi.org/10.1111/raq.12524 . image

Effects of the protein GCP4 on gametophyte development in Arabidopsis thaliana - Dongjing Ma; Lin Gao; Rong Han (Protoplasma, 2021)

Prediction of oral hepatotoxic dose of natural products derived from traditional Chinese medicines based on SVM classifier and PBPK modeling - Size Li; Yiqun Yu; Xiaolan Bian; Li Yao; Min Li; Yan-Ru Lou; Jing Yuan; Hai-shu Lin; Lucy Liu; Bing Han; Xiaoqiang Xiang (Archives of Toxicology, 2021)

GTree: an Open-source Tool for Dense Reconstruction of Brain-wide Neuronal Population - Hang Zhou; Shiwei Li; Anan Li; Qing Huang; Feng Xiong; Ning Li; Jiacheng Han; Hongtao Kang; Yijun Chen; Yun Li; Huimin Lin; Yu-Hui Zhang; et al. (Neuroinformatics, 2021)

Exendin-4 Reversed the PC12 Cell Damage Induced by circRNA CDR1as/miR-671/GSK3β Signaling Pathway - Hui Quan; Qiudan Chen; Kesheng Wang; Qinwan Wang; Meiling Lu; Yue Zhang; Sujing Qiang; Shaobo Xue; Lin Han; Huanhuan Zhu; Qiangyuan Fan; Meiyu Bao; et al. (Journal of Molecular Neuroscience, 2021)

Evidence-based Customized Ankle-Foot Orthosis with Energy Storage - Chih-Chun Lin; Chien-Hsien Yeh; Yi-Chun Tsai; Li-Chieh Kuo; Hsiu-Yun Hsu; Ping-Han Chuang; Kai Chang; Fong-Chin Su (Journal of Medical and Biological Engineering, 2021)

Marinobacter shengliensis subsp. alexandrii Subsp. Nov., Isolated from Cultivable Phycosphere Microbiota of Highly Toxic Dinoflagellate Alexandrium catenella LZT09 and Description of Marinobacter shengliensis Subsp. shengliensis Subsp. Nov - Xi Yang; Rong Xiang; Nurhezreen Md Iqbal; Yu-Han Duan; Xiao-Ai Zhang; Lei Wang; Lin-Zeng Yu; Jia-Zhou Li; Ming-Fei Sun; Qiao Yang; Chun-Tian Zheng; Shen-Quan Liao (Current Microbiology, 2021)

A study on the reservoir controlling characteristics and mechanism of the strike slip faults in the northern slope of Tazhong uplift, Tarim Basin, China - Zhongpei Zhang; Yuan Kang; Huixi Lin; Jun Han; Rui Zhao; Xiuxiang Zhu; Zhixing Ru; Chongyang Xiao (Arabian Journal of Geosciences, 2021)

New secondary metabolite with cytotoxicity from spawning soft coral Asterospicularia laurae in Taiwan - Jui-Hsin Su; Chih-I Liu; Mei-Chin Lu; Chi-I Chang; Min-Ying Hsieh; Yu-Chi Lin; Chang-Feng Dai; Ya-Han Zhang; Zheng-Yu Lin; Yun-Sheng Lin (Natural Product Research, 2021)

Surrogate-Based Stochastic Multiobjective Optimization for Coastal Aquifer Management under Parameter Uncertainty - Zheng Han; Wenxi Lu; Yue Fan; Jianan Xu; Jin Lin (Water Resources Management, 2021)

At3g53630 encodes a GUN1-interacting protein under norflurazon treatment - Xing-Qi Huang; Lin-Juan Wang; Meng-Juan Kong; Na Huang; Xin-Ya Liu; Han-Yu Liang; Jia-Xin Zhang; Shan Lu (Protoplasma, 2021)

Clinacanthus nutans Mitigates Neuronal Death and Reduces Ischemic Brain Injury: Role of NF-κB-driven IL-1β Transcription - Mei-Han Kao; Jui-Sheng Wu; Wai-Mui Cheung; Jin-Jer Chen; Grace Y. Sun; Wei-Yi Ong; Deron R. Herr; Teng-Nan Lin (NeuroMolecular Medicine, 2021)

Analysis of slug interference tests conducted in an artificial fracture - Yunfeng Dai; Yanrong Zhao; Jin Lin; Jiangbo Han; Xiaomin Sun; Wei Li; Jiufu Liu (Hydrogeology Journal, 2021)

Pressure Distribution and Deformation Control of Gob-Side Entry Retaining Formed by Roof Cutting Influenced by Abandoned Roadways - Xiaojie Yang; Lin Hou; Haojie Xue; Di Yuan; Jindong Cao; Zijie Han; Yubing Gao (Geotechnical and Geological Engineering, 2021)

Enhanced antioxidant capacity and upregulated transporter genes contribute to the UV-B-induced increase in blinin in Conyza blinii - Junyi Zhan; Qin Yang; Zhiyi Lin; Tianrun Zheng; Maojia Wang; Wenjun Sun; Tongliang Bu; Zizhong Tang; Chenglei Li; Xueyi Han; Haixia Zhao; Qi Wu; et al. (Environmental Science and Pollution Research, 2021)

Delayed association of acute particulate matter 2.5 air pollution exposure with loss of complexity in cardiac rhythm dynamics: insight from detrended fluctuation analysis - Tsung-Ying Tsai; Li-Wei Lo; Shin-Huei Liu; Wen-Han Cheng; Yu-Hui Chou; Wei-Lun Lin; Yenn-Jiang Lin; Shih-Lin Chang; Yu-Feng Hu; Fa-Po Chung; Jo-Nan Liao; Tze-Fan Chao; et al. (Environmental Science and Pollution Research, 2021)

Effects of degradation succession of alpine wetland on soil organic carbon and total nitrogen in the Yellow River source zone, west China - Chun-ying Lin; Xi-lai Li; Jing Zhang; Hua-fang Sun; Juan Zhang; Hui-bang Han; Qi-hua Wang; Cheng-biao Ma; Cheng-yi Li; Yu-xing Zhang; Xue-qian Ma (Journal of Mountain Science, 2021)

The Efficacy and Safety of Transcranial Direct Current Stimulation for Cerebellar Ataxia: a Systematic Review and Meta-Analysis - Tiffany X. Chen; Chen-Ya Yang; Gloria Willson; Chih-Chun Lin; Sheng-Han Kuo (The Cerebellum, 2021)

Correction to: Hispanic Spinocerebellar Ataxia Type 35 (SCA35) with a Novel Frameshift Mutation - Chih-Chun Lin; Shi-Rui Gan; Deepak Gupta; Armin Alaedini; Peter H Green; Sheng-Han Kuo (The Cerebellum, 2021)

The adaptability of typical precipitation ensemble prediction systems in the Huaihe River basin, China - Han Wang; Ping-an Zhong; Fei-lin Zhu; Qing-wen Lu; Yu-fei Ma; Sun-yu Xu (Stochastic Environmental Research and Risk Assessment, 2021)

Changes in arthropod community but not plant quality benefit a specialist herbivore on plants under reduced water availability - Po-An Lin; Chia-Ming Liu; Jia-Ang Ou; Cheng-Han Sun; Wen-Po Chuang; Chuan-Kai Ho; Natsuko Kinoshita; Gary W. Felton (Oecologia, 2021)

Simultaneously decreased temporal variability and enhanced variability-strength coupling of emotional network connectivities are related to positive symptoms in patients with schizophrenia - Yanjia Deng; Shuguang Han; Dongliang Cheng; Hui Li; Bin Zhang; Youyong Kong; Yong Lin; Yingjia Li; Ge Wen; Kai Liu (Brain Imaging and Behavior, 2021)

Sex-specific effects of cigarette smoking on caudate and amygdala volume and resting-state functional connectivity - Fuchun Lin; Xu Han; Yao Wang; Weina Ding; Yawen Sun; Yan Zhou; Hao Lei (Brain Imaging and Behavior, 2021)

Paleoglacial and paleoclimate reconstructions during the global Last Glacial Maximum in the Longriba area, eastern Tibetan Plateau - Wei-lin Yang; Ye-song Han; Xu Peng; Ze-ze Ran; Qing Liu; Geng-nian Liu (Journal of Mountain Science, 2021)

Dapagliflozin suppresses ER stress and protects doxorubicin-induced cardiotoxicity in breast cancer patients - Wei-Ting Chang; Yu-Wen Lin; Chung-Han Ho; Zhih-Cherng Chen; Ping-Yen Liu; Jhih-Yuan Shih (Archives of Toxicology, 2021)

Method for fast staining and obtaining high-magnification and high-resolution cell images of Nicotiana benthamiana - Yuanyuan Jiang; Jiangrong Peng; Yunpeng Cao; Zhiqiang Han; Ling Zhang; Wenbing Su; Shunquan Lin; Yuan Yuan; Bin Wang; Xianghui Yang; Zhike Zhang (Physiology and Molecular Biology of Plants, 2021)

Using 137Cs and 210Pbex to trace soil erosion rates for a small catchment in the mid-hills of Nepal - Yong Yuan; Donghong Xiong; Han Wu; Lin Liu; Wanxin Li; Chhabi Lal Chidi; Nirmal Mani Dahal; Nilhari Neupane (Journal of Soils and Sediments, 2021)

Influence of the Micro-deformation Characteristics of Binary Media on the Shear Behavior of Structural Plane - Hang Lin; Lu Han; Yixian Wang; Rihong Cao; Yanlin Zhao; Chong Jiang (Geotechnical and Geological Engineering, 2021)

Development of redox potential-driven fermentation process for recombinant protein expression - Jingjie Guo; Yixuan Wu; Takuji Tanaka; Yen-Han Lin (Biotechnology Letters, 2021)

Complete genome sequence of a new achyranthes virus A isolate from Achyranthes bidentata in China - Xinyang Wu; Yuchao Lai; Lanqing Lv; Kelei Han; Ziqiang Chen; Yuwen Lu; Jiejun Peng; Lin Lin; Jianping Chen; Hongying Zheng; Fei Yan (Archives of Virology, 2021)

Tree ring width‐based January–March mean minimum temperature reconstruction from Larix gmelinii in the Greater Khingan Mountains, China since AD 1765 - Yangao Jiang; Chuan Liu; Junhui Zhang; Shijie Han; Cassius E. O. Coombs; Xiaoguang Wang; Junwei Wang; Lin Hao; Shengzhong Dong (International Journal of Climatology, 2021)
A ring‐width chronology of Larix gmelinii (LG) was developed in the northern Greater Khingan Mountains region of China. The response function analyses revealed that the local mean minimum temperature of January–March ( T 1–3 ) was the most limiting factor affecting the radial growth of LG trees. Based on correlation analysis, a reconstructed T 1–3 series from 1765 to 2013 was produced using standard ring‐width chronology. The reconstruction explained 41.2% of the total variance in recorded monthly mean minimum temperatures from 1960 to 2013. The reconstructed T 1–3 series had similar variability when compared with the May–September mean temperature reconstruction in Inner Mongolia (IM) and the February–March mean minimum temperature reconstruction in Yichun (YC). This reconstructed T 1–3 series also captured the severe snow disaster and cold wave events recorded from historical documents in Heilongjiang and Inner Mongolia. Spatial correlations between reconstructed series and gridded temperature data also provided a high level of confidence. In addition, significant relationships between the reconstructed T 1–3 series and the Pacific Decadal Oscillation (PDO), El Niño–Southern Oscillation (ENSO), North Atlantic Oscillation (NAO), solar activity, indicated that the T 1–3 variation might be influenced by large‐scale ocean–atmosphere interactions.

Isolation and characterization of two new chroman-4-ones from the endophytic fungus Penicillium chrysogenum obtained from Eucommia ulmoides Oliver - Sheng-Yue Liu; Li-Zhi Wang; Yue-Fei Wang; Lin Li; Guo-Ying Han; Bing-Yang Zhang; Ying Guo; Yong-Zhi He; Shi-Ming Fang; Han Zhang (Natural Product Research, 2020)

Photosensitive hydrogels: from structure, mechanisms, design to bioapplications - Wenhui Ji; Qiong Wu; Xisi Han; Wei Zhang; Wei Wei; Liang Chen; Lin Li; Wei Huang (Science China Life Sciences, 2020)

Improving Image Correlation and Differentiation of 3D Endoluminal Lesions in the Air Spaces Using a Novel Target Gray Level Mapping Technique: A Preliminary Study of Its Application to Computed Tomographic Colonography and Comparison with Traditional Surface Rendering Method - Lih-Shyang Chen; Ta-Wen Hsu; Shao-Jer Chen; Shu-Han Chang; Chih-Wen Lin; Yu-Ruei Chen; Chin-Chiang Hsieh; Shu-Chen Han; Ku-Yaw Chang; Chun-Ju Hou (Journal of Medical and Biological Engineering, 2020)

Correction to: 4-Phenylbutyric acid protects against vasculitic peripheral neuropathy induced by ischaemia–reperfusion through attenuating endoplasmic reticulum stress - Cay‑Huyen Chen; Ping‑Chen Shih; Han‑Yu Lin; Po‑Kai Wang; Po‑Ting Pan; Ching‑Wei Chuang; Ming‑Chang Kao (Inflammopharmacology, 2020)

Dietary exposure assessment of cadmium, arsenic, and lead in market rice from Sri Lanka - Lin Liu; Jialiang Han; Xiaohang Xu; Zhidong Xu; Kasun S. Abeysinghe; Anjana J. Atapattu; P. Mangala C. S. De Silva; Qinhui Lu; Guangle Qiu (Environmental Science and Pollution Research, 2020)