Complex encounter situation modeling and prediction method for unmanned ships based on bounded rational game - Gang Wang; Xiaoyuan Wang; Quanzheng Wang; Longfei Chen; Junyan Han; Bin Wang; Huili Shi (Ocean Engineering, 2023)

Genomic insights into the genetic basis of cotton breeding in China - Yiqian Li; Zhanfeng Si; Guoping Wang; Zhuolin Shi; Jinwen Chen; Guoan Qi; Shangkun Jin; Zegang Han; Wenhao Gao; Yue Tian; Yun Mao; Lei Fang; et al. (Molecular Plant, 2023)

U–Pb ages of tuff from the Triassic Yanchang Formation in the Ordos Basin: Constraints on palaeoclimate and tectonics - Guanglin Liu; Shuang Ma; Zhongyi Zhang; Zhiguo Mao; Tianyou Han; Zhiqiang Shi (Marine and Petroleum Geology, 2023)

Proteomic analysis reveals differential responsive mechanisms in Solanum nigrum exposed to low and high dose of cadmium - Ling-Yu Song; Xiang Liu; Lu-Dan Zhang; Wen-Jun Hu; Chao-Qun Xu; Jing Li; Shi-Wei Song; Ze-Jun Guo; Chen-Yang Sun; Han-Chen Tang; Ji-Cheng Wang; Xue-Yi Zhu; et al. (Journal of Hazardous Materials, 2023)

Study of CO2 solubility enhancement by nanomaterials in carbonated water: Implications for enhanced oil recovery and CO2 storage - Xiaofei Sun; Haoyu Ning; Yuhao Shi; Guo Yu; Zixiong Jia; Mingen Han; Yanyu Zhang (Journal of Cleaner Production, 2023)

Gasification integrated with steam co-reforming of agricultural waste biomass over its derived CO2/O2/steam-mediated porous biochar for boosting H2-rich syngas production - Xuesong Zhang; Ge Kong; Xin Zhang; Kejie Wang; Quan Liu; Suan Shi; Lujia Han (Journal of Environmental Chemical Engineering, 2023)

Nano-sized alumina supported palladium catalysts for methane combustion with excellent thermal stability - Wei Shi; Guangyan Xu; Xuewang Han; Yingjie Wang; Zhi Liu; Sen Xue; Nannan Sun; Xiaoyan Shi; Yunbo Yu; Hong He (Journal of Environmental Sciences, 2023)

Investigations on the Stinger PDC cutter breaking granitoid under in-situ stress and hydrostatic pressure conditions - Chao Xiong; Zhongwei Huang; Huaizhong Shi; Han Chen; Zhenliang Chen; Wenhao He; Bo Zhang (International Journal of Rock Mechanics and Mining Sciences, 2023)

Severe shoot topping slows down berry sugar accumulation rate, alters the vine growth and photosynthetic capacity, and influences the flavoromics of Cabernet Sauvignon grapes in a semi-arid region - Hao-Cheng Lu; Meng-Bo Tian; Ning Shi; Xiao Han; Hui-Qing Li; Chi-Fang Cheng; Wu Chen; Shu-De Li; Fei He; Chang-Qing Duan; Jun Wang (European Journal of Agronomy, 2023)

Mechanical properties of auxetic circular and square tubes filled with aluminum foam - Ru Yuan Huo; Dong Han; Yi Zhang; Wei Jiang; Le Yang Fan; Xin Wei Peng; Ge Chen Jie Shi; Ming Hao Chu; Xiang Yu Zhang; Yi Min Xie; Xin Ren (Engineering Structures, 2023)

Seismic behaviour of shear critical square RC columns strengthened by large rupture strain FRP - Shi-Jie Mei; Yu-Lei Bai; Jian-Guo Dai; Qiang Han (Engineering Structures, 2023)

Matthew effect photoimmunotheranostics enabled by proton-driven nanoconverter - Jingjing Wang; Wei Zhang; Dachong Gu; Chunmei Chen; Wei Tang; Yi Ouyang; Xiaohong Liu; Shi-Yu Lu; Wei Zhang; Xingcai Zhang; Yulong Han; Jie Hu; et al. (Chemical Engineering Journal, 2023)

High-titer production of myo-inositol by a co-immobilized four-enzyme cocktail in biomimetic mineralized microcapsules - Pingping Han; Chun You; Yunjie Li; Ting Shi; Hong Wu; Yi-Heng P. Job Zhang (Chemical Engineering Journal, 2023)

Profiles and key drivers of bacteria/phage co-mediated antibiotic resistance genes during swine manure composting amended with humic acid - Meiling Shi; Zixuan Zhao; Xiaojuan Wang; Huakang Li; Jie Gu; Zilin Song; Ting Hu; Yifan Sun; Han Wang (Bioresource Technology, 2023)

A 90-Day Prognostic Model Based on the Early Brain Injury Indicators after Aneurysmal Subarachnoid Hemorrhage: the TAPS Score - Runting Li; Fa Lin; Yu Chen; Junlin Lu; Heze Han; Li Ma; Yahui Zhao; Debin Yan; Ruinan Li; Jun Yang; Shihao He; Zhipeng Li; et al. (Translational Stroke Research, 2023)

Synthesis of β-FeOOH/polyaniline heterogeneous catalyst for efficient photo-Fenton degradation of AOII dye - Huixin Xiong; Kun Shi; Jie Han; Can Cui; Yang Liu; Bailin Zhang (Environmental Science and Pollution Research, 2023)

Characterization and genome analysis of a novel phage Kayfunavirus TM1 - Kaiou Han; Xinyu Mao; Hui Liu; Yuxing Wu; Yizhou Tan; Ziyong Li; Runwen Ma; Yinan Li; Lei Li; Leping Wang; Yan Shi; Yajie Cao; et al. (Virus Genes, 2023)

Ultrasensitive fluorescence detection of multiple DNA methyltransferases based on DNA walkers and hyperbranched rolling circle amplification - Siqi Zhang; Huahao Shao; Kai-Bin Li; Wei Shi; Yichao Wang; De-Man Han; Jinggang Mo (Analytica Chimica Acta, 2023)

Cluster-bomb type magnetic biosensor for ultrasensitive detection of Vibrio parahaemolyticus based on low field nuclear magnetic resonance - Dongyu Zhang; Han Lin; Le Chen; Yangbo Wu; Jianjun Xie; Xizhi Shi; Zhiyong Guo (Analytica Chimica Acta, 2023)

m6A writer WTAP targets NRF2 to accelerate bladder cancer malignancy via m6A-dependent ferroptosis regulation - Ke Wang; Gang Wang; Gang Li; Wei Zhang; Yarong Wang; Xiaofeng Lin; Chengxian Han; Hanxuan Chen; Liang Shi; Abudoula Reheman; Jingkai Li; Zhaomin Li; et al. (Apoptosis, 2023)

A case of A133V genetic Creutzfeldt–Jakob disease presenting with bilateral thalamic lesions and atypical clinical features - Shi-Lin Yang; Shu-Fen Chen; Chong-Bo Zhao; Xiang Han (Acta Neurologica Belgica, 2023)

Responses of bacterioplankton, particle- and colony-attached bacterial communities to Phaeocystis globosa blooms in Mirs Bay, China - Rongjun Shi; Zhanhui Qi; Tingting Han; Ming Dai; Shufei Zhang; Honghui Huang (Frontiers in Marine Science, 2023)
Microalgae blooms are a frequent occurrence in coastal waters worldwide. It is reasonable to assume that these blooms have various influences on bacterial communities, which in turn may affect the development and dissipation of the bloom. However, the bacterial community characteristics, particularly of attached bacteria, associated with microalgae blooms remain unclear. In this study, we investigated the community profiles of bacteria using high-throughput sequencing during a Phaeocystis globosa bloom in Mirs Bay, southern China, in January 2021. Bacteria living in three habitats, i.e., bacterioplankton, particle-attached bacteria, and colony-attached bacteria, were studied from the exponential growth phase to the decline growth phase of the bloom. Distinct variations in bacterial community composition existed among the three habitats. Bacteroidota, Proteobacteria, and Cyanobacteria were the dominant phyla of bacterioplankton, particle–attached bacteria, and colony-attached bacteria, respectively. Richness and diversity were significantly highest ( p < 0.01) in particle-attached bacteria, followed by bacterioplankton, and lowest in colony-attached bacteria. The community diversities of bacterioplankton and particle-attached bacteria decreased significantly ( p < 0.05) as the bloom shifted from the exponential to the decline phase. During the decline growth phase of the bloom, Bacteroidota and Verrucomicrobiota were the dominant remarkably abundant bacteria in the bacterioplankton community, whereas Verrucomicrobiota was dominant in the particle-attached bacteria community. No significant difference was observed in the colony-attached bacterial community between the exponential and decline phases of the P. globosa bloom owing to their complex network. The results of this study suggest that P. globose bloom has a profound impact on marine bacteria, particularly species that can decompose organic matter, which could play a crucial role in the dissipation of algal blooms.

Evaluation of BDE-47-induced neurodevelopmental toxicity in zebrafish embryos - Juan Zhuang; Zheng-jun Pan; Ying Qin; Hui Liang; Wen-feng Zhang; Ze-yu Sun; Han-bo Shi (Environmental Science and Pollution Research, 2023)

Fish DDX3 enhances antiviral immunity by up-regulating antiviral interferon responses - Wen Shi; Na Wang; Bing Han; Mengmeng Zhang; Yanxue Shi; Dandan Zhao; Yanzi Zhang; Fengxia Zhao; Xueting Guan; Jinshan Huang; Min Liu (Aquaculture, 2023)

Analytical study and field investigation on the effects of clogging in slurry shield tunneling - Meng-Bo Liu; Shao-Ming Liao; Zhen-Hao Shi; Han-Kai Liu; Li-Shen Chen (Tunnelling and Underground Space Technology, 2023)

Quantitative models and potential surrogates for rapid evaluation and surveillance of chlorine disinfection efficacy in reclaimed water - Zhuo Chen; Qi Shi; Meiying Xu; Han Yan; Kefan Cao; Yu Mao; Yinhu Wu; Hong-Ying Hu (Science of The Total Environment, 2023)

Parametrical study on an array of point absorber wave energy converters - Meng Han; Feifei Cao; Hongda Shi; Hailei Kou; Haoxiang Gong; Cui Wang (Ocean Engineering, 2023)

Rebuilding the crop-livestock integration system in China ——Based on the perspective of circular economy - Zhen Han; Cheng Han; Zizhong Shi; Jinkai Li; Erga Luo (Journal of Cleaner Production, 2023)

Concomitant oxidation of fatty acids other than DHA and EPA plays a role in the characteristic off-odor of fish oil - Yun-Qi Wen; Chang-Hu Xue; Hong-Wei Zhang; Li-Li Xu; Xiao-Han Wang; Shi-Jie Bi; Qian-Qian Xue; Yong Xue; Zhao-Jie Li; Joaquín Velasco; Xiao-Ming Jiang (Food Chemistry, 2023)

Facile synthesis of novel helical imprinted fibers based on zucchini-derived microcoils for efficient recognition of target protein in biological sample - Xinya Xu; Yundong Xie; Pengqi Guo; Yongheng Shi; Meng Sun; Jing Zhou; Chuan Wang; Chaojun Han; Jiping Liu; Ting Li (Food Chemistry, 2023)

Omics analysis revealed the possible mechanism of streptococcus disease outbreak in tilapia under high temperature - Zaoya Zhao; Qianxing Zou; Shuyu Han; Jingu Shi; Haijun Yan; Dasheng Hu; Yi Yi (Fish & Shellfish Immunology, 2023)

Regulating the time of the crop model clock: A data assimilation framework for regions with high phenological heterogeneity - Qi Yang; Liangsheng Shi; Jingye Han; Yuanyuan Zha; Jin Yu; Weixiong Wu; Kai Huang (Field Crops Research, 2023)

Porous and graphitic structure optimization of biomass-based carbon materials from 0D to 3D for supercapacitors: A review - Xiaohua Zhang; Ruyun Han; Yanzhen Liu; Hengxiang Li; Wenjing Shi; Xiaoyan Yan; Xinxin Zhao; Yongfeng Li; Baosheng Liu (Chemical Engineering Journal, 2023)

Corrigendum to “Discovery and characterization of the flavonoids in Cortex Mori Radicis as naturally occurring inhibitors against intestinal nitroreductases” [Chem. Biol. Interact. 368 (2022) 110222] - Xi Chen; Yue Han; Lu Chen; Qian-Lin Tian; Yu-Ling Yin; Qi Zhou; Shi-Zhu Zang; Jie Hou (Chemico-Biological Interactions, 2023)

The Arabidopsis LARP1s are Involved in Regulation of Seed Germination - Zongyun Yan; Meng Jing; Bangyue Zhang; Huiying Shi; Xu Jin; Xiaoyuan Yan; Tiao Gao; Yuzhen Han (Journal of Plant Growth Regulation, 2023)

QTL detection for internode diameter and its association with yield-related traits in wheat - Haitao Yu; Yanan Liu; Zongfeng Zou; Xusheng Sun; Jinshan Zhang; Shun Song; Lijie Wang; Ran Qin; Han Sun; Fa Cui; Chunhua Zhao; Shubing Shi (Cereal Research Communications, 2023)

Enhancing intercity transportation will improve the equitable distribution of high-quality health care in China - Han Zhang; Bing-Bing Zhou; Shuwen Liu; Guohua Hu; Xing Meng; Xiaojuan Liu; Hong Shi; Yukun Gao; Haiyan Hou; Xia Li (Applied Geography, 2023)

Effects of H2O2 acclimation on the growth, polysaccharide production and tolerance performance of Nostoc flagelliforme - Shu-ting Liu; Shuai Wang; Na Han; Meng-yuan Li; Jian Li; Yan-ru Li; Shi-ru Jia; Pei-pei Han (Algal Research, 2023)

Automatic identification of seismic faults via integrating Residual Network-50 residual blocks and convolutional block attention modules - Xin-Wei Wang; Su-Zhen Shi; Xu-Jun Yao; Jin-Bo Pei; Yi-Fan Wang; Han-Bo Yang; Dan-Qing Liu (Applied Geophysics, 2023)

Initial Design of a Novel Barge-Type Floating Offshore Wind Turbine in Shallow Water - Yiming Zhou; Sensen Feng; Xiaojiang Guo; Feng Tian; Xu Han; Wei Shi; Xin Li (Journal of Marine Science and Engineering, 2023)
The studies on floating offshore wind turbines (FOWTs) have been increasing over recent decades due to the growing interest in offshore renewable energy. The present paper proposes a barge platform with four moonpools to support the Technical University of Denmark 10 MW wind turbine for a designed water depth of 60 m. A 4 × 2 mooring system with eight mooring lines is also proposed for the barge platform. The main dimensions of the barge platform are optimally selected with respect to its preliminary hydrodynamic properties and potential financial benefit. The proposed barge-type FOWT is then demonstrated to be aligned with the DNV standard requirements in terms of its intact and damage stability. Furthermore, coupled time-domain simulations are conducted for the proposed barge FOWT with mooring under the selected environmental and operational conditions by using Simo-Riflex-AeroDyn (SRA). Through decay test simulations, the natural periods of the barge-type FOWT are demonstrated to be within the DNV recommended ranges. The proposed mooring system is also benchmarked with the 3 × 3 mooring concept that was used for a 3 MW barge-type FOWT installed in Kitakyushu. The response magnitudes of the barge platform and mooring line tension are similar to both mooring systems, and thus the 4 × 2 mooring system is preferred due to its lower cost. In addition, the proposed barge platform is preliminarily demonstrated to be able to survive for the 50-year extreme environmental conditions under parked wind turbine status, as well as the normal environmental conditions under the operating status.

Effect of DIN and DON sources on the nitrogen uptake of the seagrass Zostera japonica and the macroalgae Ulva pertusa previously grown in different light levels - Qiuying Han; Chongyu Qiu; Wenxuan Zeng; Yu Chen; Muqiu Zhao; Yunfeng Shi; Fengying Zheng (Frontiers in Marine Science, 2023)
This study quantified the absorption ability of the seagrass Zostera japonica and the macroalgae Ulva pertusa for dissolved inorganic nitrogen (DIN) (ammonium and nitrate) and dissolved organic nitrogen (DON) (urea and glycine) under different light conditions. The plants were cultured in filtered seawater (31‰, 25°C) for 2 weeks under three light levels. Macroalgae and the above- and belowground parts of seagrasses were separately placed into four different manmade seawater solutions with DIN (ammonium and nitrate) and DON (urea and glycine) stable isotopes for 1 h. The results showed that macroalgae had higher absorption rates for ammonium and nitrate after higher light (14.67 ± 2.50 and 1.29 ± 0.16 mg −1 dry weight (DW) h −1 ) than after lower light (4.52 ± 0.95 and 0.18 ± 0.12 mg −1 DW h −1 ) treatments. Compared to the belowground seagrass portions that had previously been grown in high and low light conditions, the seagrass leaves assimilated ammonium more quickly. Z. japonica preferred glycine to nitrate and urea after the high- and low-light treatments; that is, the absorption rates of the belowground seagrass parts for glycine were 14.71 ± 1.85 and 6.38 ± 0.52 mg −1 DW h −1 after the high- and low-light treatments, respectively, which were higher than those of ammonium, nitrate, and urea. The absorption rates of algae were lower than those for ammonium previously grown under medium- and low-light treatments. These results indicate that light reduction can impact the assimilation of DIN by Z. japonica and U. pertusa , and both have the ability to directly assimilate DON. This study provides information that could help reduce the negative effects of eutrophication on macroalgae and seagrasses in order to protect seagrass meadows.

Organophosphate esters (OPEs) in a coral reef food web of the Xisha Islands, South China Sea: Occurrence, trophodynamic, and exposure risk - Yaru Kang; Ruijie Zhang; Kefu Yu; Minwei Han; Haolan Li; Annan Yan; Fang Liu; Jingwen Shi; Yinghui Wang (Chemosphere, 2023)

Perfluorooctanoic acid and perfluorooctanesulfonic acid induce immunotoxicity through the NF-κB pathway in black-spotted frog (Rana nigromaculata) - Zhiquan Liu; Huikang Lin; Yueyue Zheng; Yixuan Feng; Chaoli Shi; Ruoxin Zhu; Xingyao Shen; Yu Han; Hangjun Zhang; Yuchi Zhong (Chemosphere, 2023)

Sodium para-aminosalicylic acid ameliorates brain neuroinflammation and behavioral deficits in juvenile lead-exposed rats by modulating MAPK signaling pathway and alpha-synuclein - Zhao-cong Li; Yue-song Zhao; Jun-jie Lin; Lei-lei Wang; Han-xiao Song; Cui-liu Gan; Xiao-wei Zheng; Shi-yan Ou; Michael Aschner; Yue-ming Jiang; Jing-jing Luo; Yan Li (Toxicology Letters, 2023)

Metagenomics reveals the response of antibiotic resistance genes to elevated temperature in the Yellow River - Qiaoling Yu; Qian Han; Shunqin Shi; Xiaofang Sun; Xiaochen Wang; Sijie Wang; Jiawei Yang; Wanghong Su; Zhibiao Nan; Huan Li (Science of The Total Environment, 2023)

Enrofloxacin exposure induces anxiety-like behavioral responses in zebrafish by affecting the microbiota-gut-brain axis - Dandan Tian; Wei Shi; Yihan Yu; Weishang Zhou; Yu Tang; Weixia Zhang; Lin Huang; Yu Han; Guangxu Liu (Science of The Total Environment, 2023)

New study sheds light on the impressive intraspecific variation of Quaternary Asiatic black bears in China - Haiqian Hu; Haowen Tong; Haidong Yu; Fei Han; Jingsong Shi; Can Xiong; Yang Yu; Muhammad Ilyas; Xunqian Wang; Xi Chen (Quaternary International, 2023)

A novel protein domain is important for photosystem II complex assembly and photoautotrophic growth in angiosperms - Wei Li; Jiangfan Guo; Xue Han; Xiaowen Da; Kai Wang; Hongfei Zhao; Shi-Tang Huang; Bosheng Li; Hang He; Ruirui Jiang; Shichen Zhou; Peng Yan; et al. (Molecular Plant, 2023)

Seasonal variation of transit time distribution and associated hydrological processes in a Moso bamboo watershed under the East Asian monsoon climate - Jianfeng Gou; Simin Qu; Huade Guan; Peng Shi; Zhicai Zhang; Hai Yang; Jintao Liu; Zhiguo Su; Xiaole Han (Journal of Hydrology, 2023)

Prospective on the recovery of waste iron phosphate: Structure regulation by calcination and dissolution kinetics in acid solution - Xiao-jian Wang; Ying Zhang; Shi-li Zheng; Yang Zhang; Shan Qiao; Zhi-qi Long; Ruo-kui Chen; Shuai Han (Journal of Cleaner Production, 2023)

Geochemical distortion on shale oil maturity caused by oil migration: Insights from the non-hydrocarbons revealed by FT-ICR MS - Ming Yuan; Songqi Pan; Zhenhua Jing; Stefanie Poetz; Quan Shi; Yuanjia Han; Caineng Zou (International Journal of Coal Geology, 2023)

Geographic distributions and the regionalization of soybean seed compositions across China - Wenwen Song; Shi Sun; Tingting Wu; Ruping Yang; Shiyan Tian; Cailong Xu; Bingjun Jiang; Shan Yuan; Wensheng Hou; Cunxiang Wu; Tianfu Han (Food Research International, 2023)

Predicting ozone formation in petrochemical industrialized Lanzhou city by interpretable ensemble machine learning - Li Wang; Yuan Zhao; Jinsen Shi; Jianmin Ma; Xiaoyue Liu; Dongliang Han; Hong Gao; Tao Huang (Environmental Pollution, 2023)

Electrolyte additive of sorbitol rendering aqueous zinc-ion batteries with dendrite-free behavior and good anti-freezing ability - Yuhui Quan; Ming Yang; Minfeng Chen; Weijun Zhou; Xiang Han; Jizhang Chen; Bo Liu; Siqi Shi; Peixin Zhang (Chemical Engineering Journal, 2023)

Stabilizing zinc deposition through solvation sheath regulation and preferential adsorption by electrolyte additive of lithium difluoro(oxalato)borate - Weijun Zhou; Minfeng Chen; Yuhui Quan; Jing Ding; Hanlin Cheng; Xiang Han; Jizhang Chen; Bo Liu; Siqi Shi; Xinwu Xu (Chemical Engineering Journal, 2023)

SWCNTs/Ag2Se film with superior bending resistance and enhanced thermoelectric performance via in situ compositing - Qin-Xue Hu; Wei-Di Liu; Li Zhang; Wei Sun; Han Gao; Xiao-Lei Shi; Yan-Ling Yang; Qingfeng Liu; Zhi-Gang Chen (Chemical Engineering Journal, 2023)

Dual metal-organic frameworks-derived Fe-atomic sites bounded to fine Fe/Fe C nanoparticles for enhanced oxygen electroreduction - Meixin Chen; Fantao Kong; Heliang Yao; Yafeng Chen; Ge Meng; Ziwei Chang; Chang Chen; Han Tian; Lianzhou Wang; Xiangzhi Cui; Jianlin Shi (Chemical Engineering Journal, 2023)

Organic spacer engineering of Ruddlesden-Popper perovskite materials toward efficient and stable solar cells - Jiamin Xu; Jiabang Chen; Shi Chen; Han Gao; Yaru Li; Zhengyan Jiang; Yong Zhang; Xingzhu Wang; Xunjin Zhu; Baomin Xu (Chemical Engineering Journal, 2023)

Multifunctional PVCL nanogels enable magnetic resonance imaging and immunostimulated radiotherapy of orthotopic glioblastoma - Meijuan He; Tingting Xiao; Yihui Wang; Hongwei Yu; Zilin Wang; Xiangyang Shi; Han Wang (Chemical Engineering Journal, 2023)

Targeting N6-methyladenosine reader YTHDF1 promotes second near-infrared Nano-Photothermal immunotherapy - Yangyang Du; Xinlun Dai; Mingda Han; Zhihua Wang; Yiqiao Wang; Zhan Shi; Fei Yan; Shouhua Feng (Chemical Engineering Journal, 2023)

Disruption of phosphate metabolism and sterol transport-related genes conferring yeast resistance to vanillin and rapid ethanol production - Fengguang Zhao; Yaping Zhang; Jian Hu; Ce Shi; Xiang Ao; Shengding Wang; Ying Lin; Zhongwei Sun; Shuangyan Han (Bioresource Technology, 2023)

Impact of flow velocity on the heterogeneous reaction of SO2 over Fe2O3 - Yangyang Liu; Tao Wang; Qiuyue Ge; Zhuocheng Shi; Kejian Li; Kedong Gong; Lifang Xie; Wei Wang; Qianlong Wang; Jin Han; Hongbo Fu; Jianmin Chen; et al. (Atmospheric Environment, 2023)

Newest perspectives of glycopeptide antibiotics: biosynthetic cascades, novel derivatives, and new appealing antimicrobial applications - Li Tian; Shi Shi; Xiangmei Zhang; Fubo Han; Huijun Dong (World Journal of Microbiology and Biotechnology, 2023)

MicroRNA let-7d attenuates hypertrophic scar fibrosis through modulation of iron metabolism by reducing DMT1 expression - Bin Zhao; Xueqin Shi; Dengchao Feng; Juntao Han; Dahai Hu (Journal of Molecular Histology, 2023)

Spatial–temporal dynamics of the built environment toward sustainability: A material stock and flow analysis in Chinese new and old urban areas - Dong Yang; Mengyuan Dang; Jing Guo; Lingwen Sun; Ruirui Zhang; Feng Han; Feng Shi; Qian Liu; Hiroki Tanikawa (Journal of Industrial Ecology, 2023)
The urban built environment has accumulated massive amounts of resources, which is the main “hot spot” of construction materials and energy consumption in cities. To effectively monitor and manage resources use and waste disposal toward sustainability, this study intended to explore different metabolic paths of the urban built environment, as well as strategies for new and old urban areas separately with the help of material stock and flow analysis. Based on snapshots of 2003, 2010, and 2017 and combined with big data, a four‐dimensional geographic information system buildings database of Lixia District in Jinan, China, was compiled for bottom‐up stock modeling. Finally, the environmental impact assessment of the buildings’ demolition and disposal stage was carried out. The results showed that the building material stock was 142.31 Mt in 2017, with an increase of 69% from 2003. The reinforced concrete buildings increased rapidly from 2003 to 2017, especially in new urban areas, which has boosted demand for steel and cement by more than 150% during these 15 years. The material stock of the old urban area tends to be saturated, whereas the new urban area has experienced a rapid expansion with the material inflow four times as large as the material outflow. Potential recycling of waste concrete can reduce the generation of building demolition waste by 50%, save 0.15 km 2 of land occupation, increase raw material substitution by nearly 10 times, and reduce CO 2 emissions by 2.5 times.

Water quality assessment and pollution source apportionment using multivariate statistical techniques: a case study of the Laixi River Basin, China - Jie Xiao; Dongdong Gao; Han Zhang; Hongle Shi; Qiang Chen; Hongfei Li; Xingnian Ren; Qingsong Chen (Environmental Monitoring and Assessment, 2023)

Variation of soil-plant-atmosphere continuum stable isotope and water source in Qinghai spruce forest of the eastern Qilian Mountains - Jun-ju Zhou; Xue Wang; Luo Ma; Chu-yu Luo; Hai-tao Tang; Zhao-nan Guo; Jia-wei Chen; Su-han Shi; Wei Shi; Wei Wei; Dong-xia Zhang; Chun-fang Liu (Journal of Mountain Science, 2023)

Symbiont-screener: A reference-free tool to separate host sequences from symbionts for error-prone long reads - Mengyang Xu; Lidong Guo; Yanwei Qi; Chengcheng Shi; Xiaochuan Liu; Jianwei Chen; Jinglin Han; Li Deng; Xin Liu; Guangyi Fan (Frontiers in Marine Science, 2023)
Metagenomic sequencing facilitates large-scale constitutional analysis and functional characterization of complex microbial communities without cultivation. Recent advances in long-read sequencing techniques utilize long-range information to simplify repeat-aware metagenomic assembly puzzles and complex genome binning tasks. However, it remains methodologically challenging to remove host-derived DNA sequences from the microbial community at the read resolution due to high sequencing error rates and the absence of reference genomes. We here present Symbiont-Screener ( https://github.com/BGI-Qingdao/Symbiont-Screener ), a reference-free approach to identifying high-confidence host’s long reads from symbionts and contaminants and overcoming the low sequencing accuracy according to a trio-based screening model. The remaining host’s sequences are then automatically grouped by unsupervised clustering. When applied to both simulated and real long-read datasets, it maintains higher precision and recall rates of identifying the host’s raw reads compared to other tools and hence promises the high-quality reconstruction of the host genome and associated metagenomes. Furthermore, we leveraged both PacBio HiFi and nanopore long reads to separate the host’s sequences on a real host-microbe system, an algal-bacterial sample, and retrieved an obvious improvement of host assembly in terms of assembly contiguity, completeness, and purity. More importantly, the residual symbiotic microbiomes illustrate improved genomic profiling and assemblies after the screening, which elucidates a solid basis of data for downstream bioinformatic analyses, thus providing a novel perspective on symbiotic research.

Progress of Combined Wind and Wave Energy Harvesting Devices and Related Coupling Simulation Techniques - Feifei Cao; Mingqi Yu; Bing Liu; Zhiwen Wei; Lei Xue; Meng Han; Hongda Shi (Journal of Marine Science and Engineering, 2023)
The use of combined wind and wave energy harvesting devices (CWWHDs) is an effective way to synergistically capture offshore wind and wave energy. However, the form of combined energy harvesting and coupled simulation techniques limit the development of CWWHDs. This paper classifies the existing CWWHDs based on wave energy converters and offshore wind turbines, summarizes the theoretical background and implementation forms of the numerical simulation of CWWHDs, and focuses on the technical details of wind-wave coupling and multi-body coupling simulation, which fills the gap in the research of the wind-wave coupling and multi-body coupling numerical simulation of CWWHDs. Finally, the current research focus and development direction of CWWHDs and their numerical simulation technology are summarized to provide a reference for the future development and application of CWWHDs and numerical simulation technology.

Variation of lead bioaccessibility in soil reference materials: Intra- and inter-laboratory assessments - Xiaoyue Huang; Minghui Chang; Lei Han; Jie Li; Shi-Wei Li; Hong-Bo Li (Chemosphere, 2023)

Integrated electro-Fenton system based on embedded U-tube GDE for efficient degradation of ibuprofen - Kaiqiang Shi; Yi Wang; Anlin Xu; Hongwei Zhu; Liankai Gu; Xiaodong Liu; Jinyou Shen; Weiqing Han; Kajia Wei (Chemosphere, 2023)

Using colloidal AFM probe technique and XDLVO theory to predict the transport of nanoplastics in porous media - Li-Juan Feng; Zong-Lin Shi; Jian-Lu Duan; Yi Han; Xiao-Dong Sun; Jing-Ya Ma; Xiao-Yu Liu; Huan-Xin Zhang; Ning Guo; Chao Song; Wan-Song Zong; Xian-Zheng Yuan (Chemosphere, 2023)

Multi-index assessment of heavy metal contamination in surface sediments of the Pearl River estuary intertidal zone - Rui-Ze Liang; Yang-Guang Gu; Hai-Song Li; Yan-Jie Han; Jie Niu; Hong Su; Richard W. Jordan; Xiang-Tian Man; Shi-Jun Jiang (Marine Pollution Bulletin, 2023)

International crew changes amid global pandemic outbreaks: Key issues and system innovations - Wenjie Han; Jihong Chen; Kui Wei; Jia Shi; Guoling Jia (Marine Policy, 2023)

Mapping Chinese annual gross primary productivity with eddy covariance measurements and machine learning - Xian-Jin Zhu; Gui-Rui Yu; Zhi Chen; Wei-Kang Zhang; Lang Han; Qiu-Feng Wang; Shi-Ping Chen; Shao-Min Liu; Hui-Min Wang; Jun-Hua Yan; Jun-Lei Tan; Fa-Wei Zhang; et al. (Science of The Total Environment, 2023)

The valence state of iron-based nanomaterials determines the ferroptosis potential in a zebrafish model - Naying Zheng; Xiaolian Sun; Yiyue Shi; Luheng Chen; Luanjin Wang; Haoxing Cai; Changshun Han; Tingting Liao; Chunyan Yang; Zhenghong Zuo; Chengyong He (Science of The Total Environment, 2023)

Efficient biodegradation of acetoacetanilide in hypersaline wastewater with a synthetic halotolerant bacterial consortium - Yanqing Zhang; Ke Shi; Hanlin Cui; Jinglong Han; Hao Wang; Xiaodan Ma; Zhiling Li; Ling Zhang; Shichen Nie; Changshui Ma; Aijie Wang; Bin Liang (Journal of Hazardous Materials, 2023)

Designing of 3D MnO2-graphene catalyst on sponge for abatement temperature removal of formaldehyde - Lei Shi; Xudong Zhou; Yujie Guo; Yunyu Li; Chenxu Yan; Qifeng Han; Lingfan Zhang; Wenqing Zhang (Journal of Hazardous Materials, 2023)

Agglomeration of the new energy industry and green innovation efficiency: Does the spatial mismatch of R&D resources matter? - Tuochen Li; Ziyi Shi; Dongri Han; Jingwei Zeng (Journal of Cleaner Production, 2023)

Bio-solubilization of Yunnan lignite by Penicillium ortum MJ51 and characterization of its products - Shiying Li; Fang Li; Peipei Li; Yi Wang; Qiuzhe Shi; Xiaoqi Liu; Jinfang Tan; Yanlai Han (Fuel, 2023)

Region, vintage, and grape maturity co-shaped the ionomic signatures of the Cabernet Sauvignon wines - Xiao Han; Hao-Cheng Lu; Yu Wang; Xiao-Tong Gao; Hui-Qing Li; Meng-Bo Tian; Ning Shi; Ming-Yu Li; Xiao-Li Yang; Fei He; Chang-Qing Duan; Jun Wang (Food Research International, 2023)

A chemometric study on the identification of 5-methylfurfural and 2-acetylfuran as particular volatile compounds of oxidized fish oil based on SHS-GC-IMS - Yun-Qi Wen; Hong-Wei Zhang; Chang-Hu Xue; Xiao-Han Wang; Shi-Jie Bi; Li-Li Xu; Qian-Qian Xue; Yong Xue; Zhao-Jie Li; Joaquín Velasco; Xiao-Ming Jiang (Food Chemistry, 2023)

Risk assessment of marine oil spills using dynamic Bayesian network analyses - Zengkai Liu; Zhonghao Han; Qi Chen; Xuewei Shi; Qiang Ma; Baoping Cai; Yonghong Liu (Environmental Pollution, 2023)

“Cocktail” anti-tumor strategy through enhanced antigen exposure with photothermal/chemodynamic therapy - Mengchao Ding; Haoyu Chen; Tianyi Wang; Lijuan Wu; Kai Shao; Lei Han; Xiaoying Kong; Jinsheng Shi (Chemical Engineering Journal, 2023)

A biomimetic polymer-clay nanocomposite coating for dendrite-free Zn metal anode - Xu Liu; Qingxin Ma; Mingdi Shi; Qigang Han; Chunguo Liu (Chemical Engineering Journal, 2023)

Tuning emission color of Eu2+-activated phosphor through phase segregation - Shujuan Zhao; Shuzhen Liao; Rou Shi; Jilin Zhang; Yue Han; Shixun Lian (Chemical Engineering Journal, 2023)

Visible light-triggered smart photoreversible color switching systems based on VOx QDs for constructing smart corrosion resistant coatings on AA2024-T3 - Sharjeel Ahmed; Hongwei Shi; Ningjie Gao; Fuchun Liu; Izuchukwu K. Nwokolo; Jiwen Li; Wanyu Zhang; Mustehsin Ali; Imran Ali; En-Hou Han (Chemical Engineering Journal, 2023)

3D porous structure assembled from MXene via breath figure method for electrochemical detection of dopamine - Junming Zhang; Yingyi Ma; Yuhang Han; Kaizheng Xu; Shun Yao; Lei Shi; Min Zhu (Chemical Engineering Journal, 2023)

Composites based on electrospun fibers modified with cellulose nanocrystals and SiO2 for selective oil/water separation - Dong Wang; Sameer Mhatre; Jingqian Chen; Xuetong Shi; Haiying Yang; Wanli Cheng; Yiying Yue; Guangping Han; Orlando J. Rojas (Carbohydrate Polymers, 2023)

Role of NF-κB in lead exposure-induced activation of astrocytes based on bioinformatics analysis of hippocampal proteomics - Shi Fan; Wang Weixuan; Hao Han; Zhang Liansheng; liu Gang; Wang Jierui; Zhang Yanshu (Chemico-Biological Interactions, 2023)

Optimization of clofibrate with natural product sesamol for reducing liver injury induced by acetaminophen - Chuchu Han; Linyang Zhang; Yuxin Hua; Haitao Liu; Jiping Liu; Yongheng Shi; Xiaoping Wang; Wei Wang; Yi Jiang; Huawei Zhang; Chong Deng; Yundong Xie; et al. (Medicinal Chemistry Research, 2023)

Interactive Effects of Iron and Photoperiods on Tomato Plant Growth and Fruit Quality - Yi Zhang; Yi Liang; Jing Han; Xiaohui Hu; Xiaojing Li; Hailiang Zhao; Longqiang Bai; Yu Shi; Golam Jalal Ahammed (Journal of Plant Growth Regulation, 2023)

Single-walled carbon nanotubes-based RNA protection and extraction improves RT-qPCR sensitivity for SARS-CoV-2 detection - Yong Li; Xiangning Han; Xiaofeng Mu; Ye Wang; Chao Shi; Cuiping Ma (Analytica Chimica Acta, 2023)

Sea ice image classification based on ResFPG network and heterogeneous data fusion - Yanling Han; Xi Shi; Jing Wang; Yun Zhang; Zhonghua Hong; Zhenling Ma; Ruyan Zhou (International Journal of Remote Sensing, 2022)

Network pharmacological investigation into the mechanism of Kaixinsan powder for the treatment of depression - Li-Jing Du; Xin-Ning Zhang; Sha-Sha Li; Yuan-Fang Sun; Hui-Zi Jin; Shi-Kai Yan; Chuan-Gang Han (Metabolic Brain Disease, 2022)

Immunogenicity and protective efficacy of a DNA vaccine inducing optimal expression of the SARS-CoV-2 S gene in hACE2 mice - Zhuo-xin Li; Sheng Feng; He Zhang; Xin-yu Zhuang; Chao Shang; Shi-yu Sun; Ji-cheng Han; Yu-biao Xie; Jin-yong Zhang; Wei Wang; Cheng-hui Li; Guan-yu Zhao; et al. (Archives of Virology, 2022)

Decomposition analysis, decoupling status, and future trends of energy consumption in China’s iron and steel industry - Xiaoling Wang; Chang Lu; Baofeng Shi; Yu Chen; Zixuan Han; Jatin Nathwani (Environment, Development and Sustainability, 2022)

The effect of reservoir expansion from underground karst cave to surface reservoir on water quality in southwestern China - Meng Lu; Xiao-Dan Wang; Fu-Jun Yue; Zi-Han Liu; Zhi-Yu Shi; Ping Zhang (Environmental Science and Pollution Research, 2022)

Numerical Simulation of the Maneuvering Motion Wake of an Underwater Vehicle in Stratified Fluid - Chang Shi; Xide Cheng; Zuyuan Liu; Kunyu Han; Penghui Liu; Long Jiang (Journal of Marine Science and Engineering, 2022)
When a vehicle moves underwater, disturbance is generated and a wake remains that destroys the original free surface and produces a new wake. In order to study the mechanism and characteristics of the wave-making wake generated by the maneuvering motion of an underwater vehicle in density-stratified fluid, the k-ε model and the VOF method that is based on the RANS equation were used in this paper to analyze the SUBOFF model in stratified fluid at different drift angles. Numerical simulation of the maneuvering motion was carried out under these angles, and the corresponding changes in flow field caused by this motion were analyzed. The results from the comparison and analysis of the surface wave wakes under different drift angles in stratified fluid show that with the increasing drift angle, the motion wake of the vehicle still exhibits obvious Kelvin wave system characteristics. However, there are significant changes in hydrodynamic performance. The asymmetry of the surrounding flow field will increase with the increase in the drift angle. The pressure of the underwater vehicle is inversely proportional to the velocity of the surrounding flow field, and the amplitude of the peak and trough of the free surface wave is linearly related to the change in the drift angle. The numerical simulation can serve as a reference for the non-acoustic detection of the motion heading of an underwater vehicle and the motion trajectory of anti-reconnaissance underwater vehicles under actual sea conditions.

Three new compounds from the dried root bark of Wikstroemia indica and their cytotoxicity against HeLa cells - Peixin Shi; Zhihui Liu; Ruyue Cen; Caihui Mao; Na Han; Jun Yin (Natural Product Research, 2022)

Double knock-in pig models with elements of binary Tet-On and phiC31 integrase systems for controllable and switchable gene expression - Qin Jin; Xiaoyu Yang; Shixue Gou; Xiaoyi Liu; Zhenpeng Zhuang; Yanhui Liang; Hui Shi; Jiayuan Huang; Han Wu; Yu Zhao; Zhen Ouyang; Quanjun Zhang; et al. (Science China Life Sciences, 2022)

Unique Pharmacology, Brain Dysfunction, and Therapeutic Advancements for Fentanyl Misuse and Abuse - Ying Han; Lu Cao; Kai Yuan; Jie Shi; Wei Yan; Lin Lu (Neuroscience Bulletin, 2022)

The association between several autophagy-related genes and their prognostic values in hepatocellular carcinoma: a study on the foundation of TCGA, GEPIA and HPA databases - Xueying Zhao; Shangqi Yin; Jingren Shi; Mei Zheng; Chaonan He; Huan Meng; Ying Han; Jin Chen; Jinyu Han; Zhengrong Yuan; Yajie Wang (Molecular Biology Reports, 2022)

Phospholipase D and phosphatidic acid mediate regulation in the biosynthesis of spermidine and ganoderic acids by activating GlMyb in Ganoderma lucidum under heat stress - Xiaofei Han; Zi Wang; Lingyan Shi; Jing Zhu; Liang Shi; Ang Ren; Mingwen Zhao (Environmental Microbiology, 2022)
Polyamines are essential for all kinds of organisms and take part in the regulation of multiple biological processes. Our previous study revealed that heat stress promoted the conversion of putrescine to spermidine and subsequently promoted the accumulation of ganoderic acids (GAs). However, how heat stress affects polyamine homeostasis remains unclear. To explore the underlying mechanism by which heat stress promoted spermidine biosynthesis, we assessed the effects of signalling molecules that respond to heat stress on spermidine biosynthesis. Our data suggested that heat stress‐induced spermidine biosynthesis and GAs accumulation via a phospholipase D (PLD)‐mediated phosphatidic acid (PA) signal. Further research revealed that the transcription factor GlMyb promoted spermidine biosynthesis via regulating spermidine synthase genes ( spds1 and spds2 ) expression by directly bonding to their promoters and it responded to heat stress and PA signal. In summary, heat stress activated GlMyb by PLD‐mediated PA signalling and subsequently induced the expression of spds1 and spds2 to promote the biosynthesis of spermidine and the accumulation of GAs. Our findings firstly reveal a detailed mechanism by which heat signalling regulates polyamine homeostasis by PLD‐mediated PA signal in fungi and provide a greater understanding of how organisms alter polyamine levels in response to environmental changes.

Associations between short-term exposure to ambient PM2.5 and incident cases of cerebrovascular disease in Yantai, China - Junyan Liu; Maobo Wang; Yang Zhao; Haotian Chen; Haiyun Liu; Baoshun Yang; Haifeng Shan; Hongyu Li; Yukun Shi; Luyang Wang; Guangcheng Wang; Chunlei Han (Environmental Science and Pollution Research, 2022)

Position Control of Heave Compensation for Offshore Cranes Based on a Particle Swarm Optimized Model Predictive Trajectory Path Controller - Hao Chen; Jinke Xie; Jingang Han; Weifeng Shi; Jean-Frédéric Charpentier; Mohamed Benbouzid (Journal of Marine Science and Engineering, 2022)
The wave compensation system can be very useful in several naval applications. It can greatly reduce the relative irregular motion between the two ships when replenishment operations are performed, or between the ship and the offshore platform, which is caused by the waves. It is widely used in offshore operations, offshore cargo transfer, oil and gas exploitation, deep-sea mining, the hoisting and recovery of submersibles, etc. However, when a crane is used in a ship or moving platform, due to the influence of the hull, the crane load movement is similar to a space ball pendulum, which causes the heave displacement to show significant nonlinear motion characteristics. Moreover, the time delay of the detection mechanism and control error could result in untimely compensation, which deteriorates the performance. Consequently, this paper proposes one advanced prediction compensation method, namely Particle Swarm Optimized Model Predictive Trajectory Path controller (PSO−MPTP), which can improve the heave compensation performance. This method, which is based on Model Predictive Control (MPC), is firstly applied to the position servo system and takes into account the heave prediction and control effects simultaneously. The heave displacement of the crane load could be predicted in multiple steps in advance and used as the input of the position loop of the compensation machine. The achieved simulations show that the proposed controller has better prediction ability, higher control accuracy, and stronger robustness.

New phenolic glycosides from Anemone chinensis Bunge and their antioxidant activity - Zeng-Guang Zhang; Yuan-Yuan Li; Bin Lin; Pei-Pei Guan; Yu Mu; Wen-Jun Qiao; Jing-Sheng Zhang; Xue-Shi Huang; Li Han (Natural Product Research, 2022)

GDNF Promotes Astrocyte Abnormal Proliferation and Migration Through the GFRα1/RET/MAPK/pCREB/LOXL2 Signaling Axis - Miaomiao Wang; Xiao Han; Wei Zha; Xiaoyu Wang; Liyun Liu; Zimu Li; Yefeng Shi; Xugang Kan; Gui Wang; Dianshuai Gao; Baole Zhang (Molecular Neurobiology, 2022)

Urinary cadmium and peripheral blood telomere length predict the risk of renal function impairment: a study of 547 community residents of Shanxi, China - Jia-Chen Zhang; Shuang-Jing Li; Jian-Yong Guo; Guo-Yan Zhang; Hui Kang; Xiu-Jing Shi; Han Zhou; Yu-Fen Liang; Wei-Tong Shen; Li-Jian Lei (Environmental Science and Pollution Research, 2022)

An Unprecedented Record Low Antarctic Sea-ice Extent during Austral Summer 2022 - Jinfei Wang; Hao Luo; Qinghua Yang; Jiping Liu; Lejiang Yu; Qian Shi; Bo Han (Advances in Atmospheric Sciences, 2022)

New insights into the mechanism of RPA in preserving genome stability - Simin Zhang; Xuejie Wang; Han Zhao; Jingyao Shi; Xuefeng Chen (Genome Instability & Disease, 2022)

Exposure to Source-Specific Particulate Matter and Health Effects: a Review of Epidemiological Studies - Jia Xu; Peng Wang; Tiantian Li; Guoliang Shi; Meng Wang; Lei Huang; Shaofei Kong; Jicheng Gong; Wen Yang; Xinhua Wang; Chunmei Geng; Bin Han; et al. (Current Pollution Reports, 2022)

Cassane diterpenoids from Caesalpinia pulcherrima and their anti-inflammatory and α -glycosidase inhibitory activities - Xin Yun; Xiu-Mei Chen; Jia-Yun Wang; Wang Lu; Zi-Han Zhang; Young Ho Kim; Shi-Chun Zong; Chun-Huan Li; Jin-Ming Gao (Natural Product Research, 2022)

Correction to: MicroRNA-124 upregulation inhibits proliferation and invasion of osteosarcoma cells by targeting sphingosine kinase 1 - Yan Zhou; Yanzhen Han; Zhitao Zhang; Zhe Shi; Liyuan Zhou; Xiaohong Liu; Xiaoyan Jia (Human Cell, 2022)

The movement and settlement behaviour of cyprids of Balanus reticulatus on the surfaces of the titanium alloys - Ke Chai; Yaohua Wu; Wei Shi; Dongxia Duan; Jinyi Wu; Enhou Han (Biofouling, 2022)

Effects of feed transition on digestive tract digestive enzyme, morphology and intestinal community in cuttlefish (Sepia pharaonis) - Maowang Jiang; Wencheng Xiao; Jingtao Ye; Liting Xu; Ruibing Peng; Qingxi Han; Zhenming Lü; Huilai Shi; Xiamin Jiang (Frontiers in Marine Science, 2022)
Sepia pharaonis is an excellent candidate for aquaculture in China. However, the low survival rate during early feed transition is a bottleneck restricting industrial development. Understanding the changes in digestive physiology and intestinal microflora during feed transition should enable us to meet their nutritional needs to improve production. In this study, we investigate the digestive enzyme of S. pharaonis and undertake histological observations of the digestive gland and intestine. The intestinal microflora 16S rRNA genes were also analyzed using high-throughput sequencing of the pre, mid, and post-feed transition stages (20, 40, and 60 days post-hatching (DPH), respectively). The digestive enzymes from the digestive gland (trypsin and chymotrypsin) rapidly decrease at 40 DPH when compared to their levels at 20 DPH, but mostly recovered by 60 DPH. The alkaline phosphatase and lipase increased sharply by 40 DPH, then peaked at 60 DPH. The intestinal digestive enzymes followed similar trends during feed transition, except for lipase activity, which decreased after 20 DPH and remained low, even at 60 DPH. Feed transition affects the morphogenesis of the digestive tract and feed transition stress leads to the impairment of the digestive gland and intestinal morphology, which reduces the digestive capacity, but almost totally recovers by 60 DPH. Moreover, the comparison of the intestinal microbial composition during feed transition revealed that the dominant phylum Bacteroidetes gradually increased to a peak at 40 DPH and then decreased until 60 DPH. The microbial composition changed with the most abundant genus Pseudomonas being replaced by Acinetobacter . The phylum and family level investigation suggested the microbiota in the rearing water had limited influence on the intestinal microbiota. The intestinal microbiota diversity increased during feed transition. This study improves our understanding of changes and adaptations in cuttlefish during feed transition.

Fine mapping and candidate gene analysis of gummy stem blight resistance in cucumber stem - Jianan Han; Shaoyun Dong; Yanxia Shi; Han Miao; Xiaoping Liu; Diane M. Beckles; Xingfang Gu; Shengping Zhang (Theoretical and Applied Genetics, 2022)

Transcriptome Profile of a Long-Juvenile Soybean Genotype Huaxia-3 Under Short and Long Photoperiod - Enoch Sapey; Bingjun Jiang; Luping Liu; Shan Yuan; Tingting Wu; Seifeldin Elrayah Ibrahim; Shi Sun; Yanlei Yue; Tianfu Han (Plant Molecular Biology Reporter, 2022)
The j allele delays flowering and enhances yield of long juvenile (LJ) soybean under short day (SD) condition. However, the underlying mechanism of j in flowering pathway of soybean is not fully known. The objective of the study is to profile the transcriptome of Huaxia-3 (HX3), a typical long juvenile soybean variety with a loss of function allele ( j ) for the J gene. This helps to identify the genes implicated in delayed flowering in the long juvenile soybean variety and the pathways involved. Phenotypic analysis revealed HX3-delayed flowering and matured later than the transgenic line with the functional J gene under SD. RNA-Seq analysis was conducted to compare the transcriptome of HX3 relative to the one overexpressing J gene under SD and long day (LD). A total of 674,800,494 clean reads were generated, of which 626,517,161 (93%) were uniquely mapped to the soybean reference genome. A total of 31 and 2311 genes were differentially expressed in the HX3 under SD and LD conditions respectively. The circadian rhythm pathway was the most significantly enriched pathway in the HX3 under SD condition. The GmELF3a ( Glyma.04G050200 ) and FLOWERING LOCUS T ( FT ) genes such as GmFT2a ( Glyma.16G150700 ) and GmFT5a ( Glyma.16G044100 ) were downregulated, whiles GmFT4 ( Glyma.08G363100 ) was upregulated in the HX3 under SD. Under LD FT homologs, GmFT4 ( Glyma.08G363100 ) was downregulated and GmFT1a ( Glyma.18G299000 ) was upregulated. Our study suggests that these FT homologs may be involved in delayed flowering of LJ soybean under SD.

Correction to: Decomposition of China’s regional carbon emission paths: an analysis of environmental input and output considering regional development differences - Xueying Sun; Xiaojun Ma; Feng Shi; Miaomiao Han; Haiyang Xie; Yuan He (Environmental Science and Pollution Research, 2022)

Decomposition of China’s regional carbon emission paths: an analysis of environmental input and output considering regional development differences - Xueying Sun; Xiaojun Ma; Feng Shi; Miaomiao Han; Haiyang Xie; Yuan He (Environmental Science and Pollution Research, 2022)

Accelerated exacerbation of global extreme heatwaves under warming scenarios - Qinmei Han; Shao Sun; Zhao Liu; Wei Xu; Peijun Shi (International Journal of Climatology, 2022)
It is generally believed that global warming drives an increase in heatwaves, but these changes vary regionally. Projected trends of heatwaves and comparisons between observed and projected heatwave trends are poorly understood. We selected multiple characteristics of global heatwave events, including indicators on heat‐related health impacts under historical and future scenarios from the NASA Earth Exchange/Global Daily Downscaled Projections (NEX‐GDDP) dataset. We quantified the trends in the frequency, intensity, duration and peak temperature of heatwave events and identified heatwave hotspots that respond dramatically to radiative forcing. Future simulations suggest a four‐fold increase in the duration of heatwaves by 2050s, spatially concentrated in central Africa, northern South America and Southeast Asia, and the maximum duration of single heatwave event will be up to 44 days under a high emission scenario. Accelerated increasing trends are also detected in intensity, total duration and temperature of heatwaves with up to 2‐fold, 8‐fold and 9‐fold larger than the trends of the baseline period under the high emission scenario. Considering socioeconomic exposure to extreme heatwaves, we identified some hotspot areas in western Europe, eastern North America and northern China that will face greater potential risks in the coming future and therefore need to urgently strengthen their adaptation capacity.

Responses of rice (Oryza sativa L.) plant growth, grain yield and quality, and soil properties to the microplastic occurrence in paddy soil - Sen Chen; Yanfang Feng; Lanfang Han; Detian Li; Yuanyuan Feng; Paramsothy Jeyakumar; Haijun Sun; Weiming Shi; Hailong Wang (Journal of Soils and Sediments, 2022)

The impact of digital economy on total factor carbon productivity: the threshold effect of technology accumulation - Dongri Han; Yingying Ding; Ziyi Shi; Yao He (Environmental Science and Pollution Research, 2022)

Longitalea arenae gen. nov., sp. nov. and Longitalea luteola sp. nov., two new members of the family Chitinophagaceae isolated from desert soil - Shuai Li; Lei Dong; Jia-Rui Han; Guo-Yuan Shi; Chun-Yan Lu; Lu Xu; Wen-Hui Lian; Dalal Hussien M. Alkhalifah; Wael N. Hozzein; Wen-Jun Li (Archives of Microbiology, 2022)

Establishment of a set of wheat-rye addition lines with resistance to stem rust - Chang Liu; Jing Wang; Shulan Fu; Long Wang; Hongwei Li; Mian Wang; Yuhong Huang; Qinghua Shi; Yonghong Zhou; Xianrui Guo; Congle Zhu; Jing Zhang; et al. (Theoretical and Applied Genetics, 2022)

Characterization, heterologous expression and engineering of trehalase for biotechnological applications - Han Gao; Jin-Song Gong; Chang Su; Heng Li; Zheng-Hong Xu; Jin-Song Shi (Systems Microbiology and Biomanufacturing, 2022)

Reliability analysis of prestressed anchors in rock slopes of open-pit mines - Min Bao; Zhong-hui Chen; Ling-fei Zhang; Zi-han Zhou; Geng-qian Nian; Shu-yao Shi (Journal of Mountain Science, 2022)

Cellulomonas triticagri sp. nov., isolated from the rhizosphere soil of wheat (Triticum aestivum L.) - Chuanyu Han; Yuting Zhang; Bing Yu; Qiqi Shan; Junwei Zhao; Haoran Shi; Yuanyuan Tian; Yan Zhang; Chunyu Zhu; Wensheng Xiang (Archives of Microbiology, 2022)

Behaviour Impact Analysis of Tuna Purse Seiners in the Western and Central Pacific Based on the BRT and GAM Models - Shenglong Yang; Han Zhang; Wei Fan; Huimin Shi; Yingjie Fei; Sanling Yuan (Frontiers in Marine Science, 2022)
Understanding the spatial pattern of human fishing activity is very important for fisheries resource monitoring and spatial management. To understand the spatial distribution of tuna purse seiner operations in the western and central Pacific Ocean and its relationship with the marine environment, this paper uses the AIS data of the western and central Pacific Tuna purse seiners from 2015 to 2020 to excavate spatial fishing effort information, which is combined with 24 marine environmental factors in the same period, including sea surface and subsurface levels using the boosted regression trees (BRT) model and general additive model (GAM) to construct the nonlinear relationship between the spatial distribution of fishing effort and marine ecological environmental factors and to discuss and analyse the niche of tuna purse seiners in the high seas. The results show that the average score of cv-AUC (cross-validated area under the curve) obtained by the BRT model training reaches 0.93, the average accuracy rate is 0.84, and the explained deviance is 43%; the average score of AUC (area under the curve) obtained by the GAM model training reaches 0.81, the average accuracy rate is 0.77, and the explained deviance is 34%. The results of BRT prior to GAM model. Using the BRT model for prediction, the results show that the average cv-AUC score for forecasting fishing effort in 2020 reaches 0.83, and the average accuracy rate of overall classification reaches 0.77. The results of factor analysis show that the water temperature at 100 m depth and longitude are the most important factors affecting the fishing effort of tuna purse seiners, and their contribution rates to the fishing effort of vessels are 12.38% and 9.76%, respectively, followed by sea surface temperature, latitude and DSH. The contribution to the fishing effort of tuna purse seiners was also large, accounting for 9.57%, 8.75%, and 7.11%, respectively; the 100-meter-deep chlorophyll and temperature gradient value contributed the least, 1.44% and 1.16%, respectively; tuna purse seiners are more likely to operate in the 100-metre water temperature of 25-29°C and sea surface temperature of 29-31°C. In terms of space, tuna purse seiners are more likely to operate in the 5°S-5°N latitudinal region and near the western sea area of 180°E. It is predicted that the modelled fishing effort of fishing vessels in 2020 and the actual fishing effort of fishing vessels have a relatively good spatial distribution. Research helps to understand the environmental impact of changes in the spatial distribution of tuna purse seiners and provides support for the management of tuna purse seine vessels in the western and central Pacific.

High On-Treatment Platelet Reactivity as Predictor of Long-term Clinical Outcomes in Stroke Patients with Antiplatelet Agents - Huihui Lv; Zidong Yang; Haibo Wu; Mingyuan Liu; Xiaowei Mao; Xu Liu; Hongyan Ding; Zhuqing Shi; Yang Zhou; Qianyun Liu; Yongkang Zhang; Yinting Zhou; et al. (Translational Stroke Research, 2022)

Cerebellar Oscillations in Familial and Sporadic Essential Tremor - Shi-Bing Wong; Yi-Mei Wang; Chih-Chun Lin; Scott Kun Geng; Nora Vanegas-Arroyave; Seth L. Pullman; Sheng-Han Kuo; Ming-Kai Pan (The Cerebellum, 2022)

Ligustilide ameliorates cognitive impairment via AMPK/SIRT1 pathway in vascular dementia rat - Dong Peng; Han-Zi Qiao; Hong-Yu Tan; Yi-Xue Wang; Dan Luo; Li-Jun Qiao; Ye-Feng Cai; Shi-Jie Zhang; Qi Wang; Li Guan (Metabolic Brain Disease, 2022)

Driving Factors, Co-occurrence Networks, and Metabolic Profiles of Soil Bacterial Communities Within the Root Proximity of Amaranthus palmeri - Mei Zhang; Xueying Li; Cong Shi; Zhenlu Qiu; Jianhua Han; Kefan Wang; Pufan Zheng; Fuchen Shi (Journal of Soil Science and Plant Nutrition, 2022)

A novel information changing rate and conditional mutual information-based input feature selection method for artificial intelligence drought prediction models - Qiongfang Li; Xingye Han; Zhennan Liu; Pengfei He; Peng Shi; Qihui Chen; Furan Du (Climate Dynamics, 2022)

Candidate master microRNA regulator of arsenic-induced pancreatic beta cell impairment revealed by multi-omics analysis - Jenna E. Todero; Kieran Koch-Laskowski; Qing Shi; Matt Kanke; Yu-Han Hung; Rowan Beck; Miroslav Styblo; Praveen Sethupathy (Archives of Toxicology, 2022)
Arsenic is a pervasive environmental toxin that is listed as the top priority for investigation by the Agency for Toxic Substance and Disease Registry. While chronic exposure to arsenic is associated with type 2 diabetes (T2D), the underlying mechanisms are largely unknown. We have recently demonstrated that arsenic treatment of INS-1 832/13 pancreatic beta cells impairs glucose-stimulated insulin secretion (GSIS), a T2D hallmark. We have also shown that arsenic alters the microRNA profile of beta cells. MicroRNAs have a well-established post-transcriptional regulatory role in both normal beta cell function and T2D pathogenesis. We hypothesized that there are microRNA master regulators that shape beta cell gene expression in pathways pertinent to GSIS after exposure to arsenicals. To test this hypothesis, we first treated INS-1 832/13 beta cells with either inorganic arsenic (iAs III ) or monomethylarsenite (MAs III ) and confirmed GSIS impairment. We then performed multi-omic analysis using chromatin run-on sequencing, RNA-sequencing, and small RNA-sequencing to define profiles of transcription, gene expression, and microRNAs, respectively. Integrating across these data sets, we first showed that genes downregulated by iAs III treatment are enriched in insulin secretion and T2D pathways, whereas genes downregulated by MAs III treatment are enriched in cell cycle and critical beta cell maintenance factors. We also defined the genes that are subject primarily to post-transcriptional control in response to arsenicals and demonstrated that miR-29a is the top candidate master regulator of these genes. Our results highlight the importance of microRNAs in arsenical-induced beta cell dysfunction and reveal both shared and unique mechanisms between iAs III and MAs III .

Duplex droplet digital PCR method for the detection of Enterocytozoon hepatopenaei and Vibrio parahaemolyticus acute hepatopancreatic necrosis disease - Huang Zhang; Han‐Yue Gong; Wei‐Wei Cao; Mu‐Yi Que; Lei Ye; Lei Shi (Journal of Fish Diseases, 2022)
Enterocytozoon hepatopenaei (EHP) and Vibrio parahaemolyticus acute hepatopancreatic necrosis disease (VPAHPND) are two of the diseases that have frequently infected farmed shrimp in recent years, causing great economic losses to the shrimp industry worldwide. In this study, we established a sensitive and accurate duplex droplet digital PCR (ddPCR) method that can simultaneously detect and quantify the two pathogens simultaneously. The results showed that the ddPCR methods could detect EHP and VPAHPND specifically. The sensitivity levels of ddPCR for EHP and VPAHPND were 2.3 copies/μl and 4.6 copies/μl, respectively, which were 10‐fold higher than the sensitivity of the qPCR assay and showed good reproducibility. Twenty‐six suspected diseased shrimp samples were used for practical determination. For EHP, the detection rates of ddPCR and qPCR were 53.84% and 42.31%, respectively; for VPAHPND, the detection rates of ddPCR and qPCR were both 23.08%. The results indicated that the ddPCR method shows superiority for detection in samples with low viral loads, which will facilitate monitoring of the source and transmission of EHP and VPAHPND and will help control shrimp epidemic disease.

Chemical composition and phytotoxic activity of the essential oil of Artemisia sieversiana growing in Xinjiang, China - Chun-Yu Jiang; Shi-Xing Zhou; Zokir Toshmatov; Yu Mei; Guang-Zhao Jin; Cai-Xia Han; Chi Zhang; Hua Shao (Natural Product Research, 2022)

Long-term clinical observation of patients with acute and chronic complete spinal cord injury after transplantation of NeuroRegen scaffold - Fengwu Tang; Jiaguang Tang; Yannan Zhao; Jiaojiao Zhang; Zhifeng Xiao; Bing Chen; Guang Han; Na Yin; Xianfeng Jiang; Changyu Zhao; Shixiang Cheng; Ziqiang Wang; et al. (Science China Life Sciences, 2022)

Productivity of Leymus chinensis grassland is co-limited by water and nitrogen and resilient to climate change - Yujie Shi; Yunna Ao; Baixin Sun; Johannes M. H. Knops; Jinwei Zhang; Zhihan Guo; Xianming De; Jiayu Han; Yuheng Yang; Xiaoyu Jiang; Chunsheng Mu; Junfeng Wang (Plant and Soil, 2022)

Experimental study on the pore and solid structures of municipal solid waste under compression based on computed tomography (CT) scans - Han Ke; Ying Liu; Meng Meng; Jie Hu; Shi Yu Zhao; Rui Qin; Xiao Wen Wu (Environmental Science and Pollution Research, 2022)

Research on the impact of energy technology innovation on total factor ecological efficiency - Tuochen Li; Ziyi Shi; Dongri Han (Environmental Science and Pollution Research, 2022)

Chemical constituents of Viscum coloratum (Kom.) Nakai and their cytotoxic activities - Ying-Ying Chen; Jiang-Ping Hou; Ling Huang; Afsar Khan; Fei-Fei Xing; Xiao-Han Zhang; De-Feng Han; Shi-Li Yan; Gui-Dong Cao; Qi-Yang Jiao; Dejie Liu; Xuwei Zhu; et al. (Natural Product Research, 2022)

Relationship between the Spatial and Temporal Distribution of Squid-Jigging Vessels Operations and Marine Environment in the North Pacific Ocean - Yingjie Fei; Shenglong Yang; Wei Fan; Huimin Shi; Han Zhang; Sanling Yuan (Journal of Marine Science and Engineering, 2022)
Information and understanding of fishing activities at sea is important to fisheries science, public authorities and policy-makers. To understand the spatial–temporal distribution characteristics of squid-jigging vessels and how the marine environment affects the distribution of squid-jigging vessels in the North Pacific Ocean, operation behavior of the squid-jigging vessels was analysed by using spatial–temporal factors and marine environmental factors. The fishing effort (FE) information was calculated based on automatic identification system (AIS) data of squid-jigging fishing vessels in the North Pacific Ocean from July to November in 2017 to 2020, and the overlay maps of the spatial distribution of environmental factors and fishing effort were plotted together with four environmental variables (sea surface temperature (SST), sea surface height (SSH), sea surface salinity (SSS), and concentration of chlorophyll-a (Chla)). A generalized additive model (GAM) was used to investigate the nonlinear influence of the marine environment on squid-jigging fishing vessel activity in the North Pacific Ocean. The results show that fishing effort increased from July to August and then decreased from September to November. The fishing effort was highest in August. The intensity of the fishing effort suggests squid-jigging vessel operations had significant seasonal variations. The overlay maps suggest that the fishing effort of squid-jigging vessels was mainly located in areas where SST was between 10∘C and 20∘C, SSH was between −0.3m and 0.2m, SSS was between 32×10−3 and 34×10−3, and Chla was between 0.1mg·m−3 and 0.4mg·m−3. The generalized additive model indicated evidence of nonlinear relationships between fishing effort and the three environmental factors. The favorable ranges of SST, SSH, SSS and Chla for fishing effort were 15∘C∼18∘C, 0∼0.2m, 33×10−3∼34×10−3 and 0.2mg·m−3∼0.4mg·m−3, respectively. Moreover, the area beneficial to fishing effort was in 41∘N∼44∘N, 152∘E∼165∘E.

Delayed rFGF21 Administration Improves Cerebrovascular Remodeling and White Matter Repair After Focal Stroke in Diabetic Mice - Yinghua Jiang; Jinrui Han; Yadan Li; Yinga Wu; Ning Liu; Samuel X. Shi; Li Lin; Jing Yuan; Shusheng Wang; Ming-Ming Ning; Aaron S. Dumont; Xiaoying Wang (Translational Stroke Research, 2022)

Synthesis and anticancer activity of Boc-Gly-Pro dipeptide-annonaceous acetogenin prodrugs targeting fibroblast activation protein or other hydrolytic enzymes - Jing-Fang Shi; Ping Wu; Han-Xiang Li; Xiao-Yi Wei; Zi-Hua Jiang (Medicinal Chemistry Research, 2022)

Sodium tanshinone IIA sulfonate improves cognitive impairment via regulating Aβ transportation in AD transgenic mouse model - Hui-Han Ma; Can Wan; Lu-Di Zhang; Rong-Rong Zhang; Dong Peng; Li-Jun Qiao; Shi-Jie Zhang; Ye-Feng Cai; Hong-Qiang Huang (Metabolic Brain Disease, 2022)

Norovirus detection in wastewater and its correlation with human gastroenteritis: a systematic review and meta-analysis - Yue Huang; Nan Zhou; Shihan Zhang; Youqin Yi; Ying Han; Minqi Liu; Yue Han; Naiyang Shi; Liuqing Yang; Qiang Wang; Tingting Cui; Hui Jin (Environmental Science and Pollution Research, 2022)

Biodiversity and degradation potential of oil-degrading bacteria isolated from sediments of hydrothermal and non-hydrothermal areas of the Southwest Mid-Indian Ocean Ridge - Haolei Shi; Jiangfeng Cheng; Wei Gao; Meng Ma; Ang Liu; Tianyi Hu; Bin Han; Li Zheng (Environmental Science and Pollution Research, 2022)

Agent-based model for simulation of the sustainability revolution in eco-industrial parks - Feng Han; Mingxing Sun; Xuexiu Jia; Jiří Jaromír Klemeš; Feng Shi; Dong Yang (Environmental Science and Pollution Research, 2022)

One-Way Intestinal Perfusion of PVP/VA–Poloxamer 188–Curcuma longa L. Extract Solid Dispersion in Rats In Vivo and Its Effect on HSC–T6 Cell Proliferation - Jie Gao; Yi Shi; Yunfeng Han; Xi Tang; Ruohong Bi; Lin Pan; Xianrong Lai (AAPS PharmSciTech, 2022)

The Extent and Pattern of Mariculture Impacts on Spatial and Seasonal Variations of Sediment Bacterial Communities Among Three Coastal Waters - Rongjun Shi; Tingting Han; Honghui Huang; Zexing Kuang; Zhanhui Qi (Frontiers in Marine Science, 2022)
Benthic sediment bacteria are important drivers for material circulation and energy flow in aquatic ecosystem, and they are sensitive to environmental changes. Large scale suspended mariculture in coastal waters induces high organic loading to the sediment through biodeposition, and causes changes in sediment biogeochemical features. However, the impacts of mariculture on sediment bacterial communities are not fully understood. In the present study, sediment samples were collected from three coastal semi-enclosed bays of China, i.e., Sanggou Bay, Daya Bay, and Maniao Bay, where large scale mariculture were carried out since the 1980s. High-throughput sequencing was used to examine the spatial and seasonal variations of bacterial communities. The results indicated that the dominant phyla of three bays were Proteobacteria (39.18–47.21%), Bacteroidetes (9.91–19.25%), and Planctomycetes (7.12–13.88%). Spatial variations played a greater role in shaping the bacterial communities than seasonal variation. The bacterial diversity indices (Chao1, Pielou’s evenness, and Shannon-Wiener index) of Sanggou Bay were significantly lower than those of Daya Bay and Maniao Bay. For seasonal variation, bacterial diversity indices in spring were significantly lower than that in autumn. Five keystone taxa belonging to Planctomycetes, Alphaproteobacteria, and Acidobacteria were identified in Sanggou Bay. Temperature, particulate organic carbon, pH, and salinity were the most important environmental factors shaping the spatial and seasonal variations of bacterial communities in the studied areas. The abundances of bacteria, particularly Bacteroidetes, Gammaproteobacteria, and Deltaproteobacteria, were significantly correlated with the mariculture-driven chemical properties of the sediment. These results indicated that intensive mariculture could induce profound and diverse impacts on the bacterial communities, and therefore modify their role in marine ecosystem. The interactions between mariculture and sediment bacterial communities should be considered in regard to mariculture management and carrying capacity.

Screening and identification of HLA-A2-restricted neoepitopes for immunotherapy of non-microsatellite instability-high colorectal cancer - Ranran Shi; Yubing Li; Ling Ran; Yu Dong; Xiuman Zhou; Jingwen Tang; Lu Han; Mingshuang Wang; Liwei Pang; Yuanming Qi; Yahong Wu; Yanfeng Gao (Science China Life Sciences, 2022)

Polysaccharide Krestin Prevents Alzheimer’s Disease-type Pathology and Cognitive Deficits by Enhancing Monocyte Amyloid-β Processing - Si-Han Chen; Chen-Yang He; Ying-Ying Shen; Gui-Hua Zeng; Ding-Yuan Tian; Yuan Cheng; Man-Yu Xu; Dong-Yu Fan; Cheng-Rong Tan; An-Yu Shi; Xian-Le Bu; Yan-Jiang Wang (Neuroscience Bulletin, 2022)

Neuroprotective effect of aldose reductase knockout in a mouse model of spinal cord injury involves NF-κB pathway - Fu-xin Han; Rui Zhang; Xin-xing Yang; Shan-bo Ma; Shi-jie Hu; Bing Li (Experimental Brain Research, 2022)

Effects of ambient fine particulate matter on oxidative stress, inflammation, and janus kinase/signal transducer and activator of transcription signal molecules: a panel study of asthmatic adults in Taiyuan, China - Nannan Liu; Xiaoyan Ma; Jing Wang; Liangpo Liu; Hong Geng; Bianzhuan Yang; Jianbiao Han; Jiayu Tian; Xin Wang; Caihong Wang; Dan Wang; Hao Shi; et al. (Air Quality, Atmosphere & Health, 2022)

Effects of Seawater Temperature and Salinity on Physiological Performances of Swimming Shelled Pteropod Creseis acicula During a Bloom Period - Tingting Han; Zhanhui Qi; Rongjun Shi; Qingxia Liu; Ming Dai; Honghui Huang (Frontiers in Marine Science, 2022)
Creseis acicula is a swimming shelled pteropod species, widely distributed in the world’s oceans. In 2020, an unprecedented bloom of C. acicula was observed in Daya Bay, and lasted from June to July. To date, there is very limited information on the physiological characteristics of this species, which is essential to understand bloom dynamics. In the present study, the physiological performances of C. acicula in response to temperature (17–35°C) and salinity (18–38 ppt) were investigated. The oxygen consumption (OCR) and calcification rates (CR) of C. acicula peaked at 32 and 26°C, respectively, while ammonia excretion rate (AER) significantly increased with increasing temperature. The thermal coefficient Q 10 (respiration) of C. acicula dropped to a minimum value between 32 and 35°C, suggesting that they were in a stressful status. The O:N ratio ranged from 3.24 to 5.13, indicating that protein was the major catabolism substrate. Temperature exerted a stronger effect on the OCR and AER of C. acicula . Salinity has a more influence on CR. The preferable temperature for C. acicula ranges from 29 to 32°C, and the preferable salinity ranges from 28 to 33 ppt. Based on a comprehensive consideration, we presumed that the warmer seawater temperature around the thermal discharge area of Daya Bay nuclear power plant is a possible cause for the bloom of C. acicula .

Carbon and nitrogen dynamics in tropical ecosystems following fire - Dalong Jiang; Chonghua Xu; Xia Xu; Yiqi Luo; Chen Chen; Chenghui Ju; Han Y. H. Chen; Zheng Shi; Honghua Ruan (Global Ecology and Biogeography, 2022)
Aim Tropical ecosystems have grown increasingly prone to fire over the last century. However, no consensus has yet emerged regarding the effects of fire disturbances on tropical biogeochemical cycles. Location Tropics. Time period 1960–2018. Major taxa studied Tropical ecosystems: Above‐ and below‐ground carbon (C) and nitrogen (N) dynamics. Methods We analysed the impacts of fire on C and N dynamics in tropical ecosystems through a meta‐analysis of 1,420 observations from 87 studies. Results Fire reduced both above‐ and below‐ground C and N pools, with greater reductions above‐ than below‐ground. Fire decreased soil total carbon (TC), total nitrogen (TN) and nitrate nitrogen ( ) and increased ammonium nitrogen ( ) in surface mineral soil layers but did not affect those in deep layers. Fire decreased TC and TN in savanna but did not affect those in tropical dry and moist forests. Fire did not affect and in savanna because of non‐significant responses of N mineralization rate (N min ) to fire. Conversely, fire increased and decreased in tropical dry forest, but did not affect and increased in tropical moist forest owing to thermal decomposition of soil organic N and increased soil nitrification, respectively. Moreover, declined and increased initially and then decreased with time after fire. Above‐ and below‐ground response variables to prescribed fire were mediated largely by fire frequency and experimental duration, respectively. Main conclusions Our results suggest a high vulnerability of the above‐ground C and N pools to fire, whereas the biogeochemical cycles below‐ground are of high complexity. Fire effects on below‐ground C and N pools, which are highly uncertain and vegetation specific, should be investigated further.

Experimental and numerical study on mechanical and fracture behavior of rock-like specimens containing pre-existing holes flaws - Zhenlong Zhao; Hongwen Jing; Xinshuai Shi; Guansheng Han (European Journal of Environmental and Civil Engineering, 2022)

Assembly of rhizosphere microbial communities in Artemisia annua: recruitment of plant growth‐promoting microorganisms and inter‐kingdom interactions between bacteria and fungi - Yuhua Shi; Yanshuo Pan; Li Xiang; Zhihui Zhu; Wenbo Fu; Guangfei Hao; Zengchao Geng; Shilin Chen; Yuzhong Li; Dongfei Han (Plant and Soil, 2022)

Transcriptomic and metabolomic reprogramming in cotton after Apolygus lucorum feeding implicated in enhancing recruitment of the parasitoid Peristenus spretus - Xinzheng Huang; Junfeng Kou; Weixia Jing; Xiaoqiang Han; Danfeng Liu; Somayyeh Ghasemzadeh; Peiyao Sun; Wangpeng Shi; Yongjun Zhang (Journal of Pest Science, 2022)

Study on the mechanism of Salvia miltiorrhiza polysaccharides in relieving liver injury of broilers induced by florfenicol - Yumeng Geng; Chunyu Lu; Guozhong Jin; Shuying Li; Yuqing Cui; Chao Han; Wanyu Shi; Yongzhan Bao (Environmental Science and Pollution Research, 2022)

Back analysis of shear strength parameters for progressive landslides: case study of the Caifengyan landslide, China - Shi Zuo; Lianheng Zhao; Dongping Deng; Zheng Han; Biao Zhao; Zhigang Zhao (Bulletin of Engineering Geology and the Environment, 2022)

Photosynthetic acclimation during low-light-induced leaf senescence in post-anthesis maize plants - Han-Yu Wu; Li-An Liu; Lei Shi; Wang-Feng Zhang; Chuang-Dao Jiang (Photosynthesis Research, 2021)

Sigma-1 Receptor Activation Suppresses Microglia M1 Polarization via Regulating Endoplasmic Reticulum–Mitochondria Contact and Mitochondrial Functions in Stress-Induced Hypertension Rats - Kokwin Ooi; Li Hu; Yi Feng; Chenzhi Han; Xiaorong Ren; Xinyi Qian; Haofeng Huang; Sijia Chen; Qi Shi; Hong Lin; Jijiang Wang; Danian Zhu; et al. (Molecular Neurobiology, 2021)

Molecular Mechanism of the ATF6α/S1P/S2P Signaling Pathway in Hippocampal Neuronal Apoptosis in SPS Rats - Liang Han; Yanhao Xu; Yuxiu Shi (Journal of Molecular Neuroscience, 2021)

Correction to: 2021 Taxonomic update of phylum Negarnaviricota (Riboviria: Orthornavirae), including the large orders Bunyavirales and Mononegavirales - Jens H. Kuhn; Scott Adkins; Bernard R. Agwanda; Rim Al Kubrusli; Sergey V. Alkhovsky; Gaya K. Amarasinghe; Tatjana Avšič-Županc; María A. Ayllón; Justin Bahl; Anne Balkema-Buschmann; Matthew J. Ballinger; Christopher F. Basler; et al. (Archives of Virology, 2021)

Identification of cryptic putative IRESs within the ORF encoding the nonstructural proteins of the human rhinovirus 16 genome - Bingtian Shi; Qinqin Song; Xiaonuan Luo; Juan Song; Dong Xia; Zhiqiang Xia; Mi Liu; Wenjun Wang; Ruifang Wang; Haijun Du; Jun Han (Archives of Virology, 2021)

2021 Taxonomic update of phylum Negarnaviricota (Riboviria: Orthornavirae), including the large orders Bunyavirales and Mononegavirales - Jens H. Kuhn; Scott Adkins; Bernard R. Agwanda; Rim Al Kubrusli; Sergey V. Alkhovsky; Gaya K. Amarasinghe; Tatjana Avšič-Županc; María A. Ayllón; Justin Bahl; Anne Balkema-Buschmann; Matthew J. Ballinger; Christopher F. Basler; et al. (Archives of Virology, 2021)

Seismic inversion-based prediction of the elastic parameters of rocks surrounding roadways: a case study from the Shijiazhuang mining area of North China - Suzhen Shi; Jian Feng; Zuiliang Liu; Youchao Qi; Peifei Duan; Qi Han; Jianping Zuo (Acta Geophysica, 2021)

Investigation into Polycyclic Aromatic Hydrocarbons in Sediments of Wei River Basin - Yongfeng Shi; Yuehan Lu; Yucheng Zhang; Xiaotong Su; Qihang Wu; Huifang Lei; Linchuan Fang; Fengbao Zhang; Zhineng Liu; Jie Han; Bixian Mai (Water, Air, & Soil Pollution, 2021)

Loganin ameliorates depression-like behaviors of mice via modulation of serotoninergic system - Chen-Hao Pan; Cong-Yuan Xia; Yu Yan; Yan Han; Rui Shi; Jun He; Ze-Xing Wang; Yu-Ming Wang; Wei-Ku Zhang; Jie-Kun Xu (Psychopharmacology, 2021)

A 168-year temperature recording based on tree rings and latitude differences in temperature changes in northeast China - Yangao Jiang; Yuting Cao; Junhui Zhang; Zhuo Li; Guoqiang Shi; Shijie Han; Cassius E. O. Coombs; Chuan Liu; Xiaoguang Wang; Junwei Wang; Lin Hao; Qi Xu; et al. (International Journal of Biometeorology, 2021)

Pepsinogen C expression–related lncRNA/circRNA/mRNA profile and its co-mediated ceRNA network in gastric cancer - Li-rong Yan; Han-xi Ding; Shi-xuan Shen; Xiao-dong Lu; Yuan Yuan; Qian Xu (Functional & Integrative Genomics, 2021)

Comparative activities of sitafloxacin against recent clinical isolates in hospitals across China - Shi Wu; Yang Yang; Yan Guo; Dandan Yin; Yonggui Zheng; Renru Han; Li Ding; Demei Zhu; Fupin Hu (European Journal of Clinical Microbiology & Infectious Diseases, 2021)

Characteristics of ambient ammonia and its effects on particulate ammonium in winter of urban Beijing, China - Rui Zhang; Yuhua Han; Aijun Shi; Xuesong Sun; Xiao Yan; Yuhu Huang; Yu Wang (Environmental Science and Pollution Research, 2021)

Optimization of hydrothermal synthesis of hydroxyapatite from chicken eggshell waste for effective adsorption of aqueous Pb(II) - Dezhi Shi; Haihang Tong; Mengying Lv; Dan Luo; Pan Wang; Xiaoyi Xu; Zhiyong Han (Environmental Science and Pollution Research, 2021)

Mutation of the sixth amino acid of the Rep protein has no effect on porcine circovirus 2b but enhances porcine circovirus 2d replication in vitro - Xiaoyan Wu; Shuo Wang; Changxun Xin; Chen Li; Jianli Shi; Zhe Peng; Chang Liu; Hong Han; Ying Yang; Yao Tian; Jiaxin Li; Shaojian Xu; et al. (Archives of Virology, 2021)

Research on stage-divided water level prediction technology of rivers-connected lake based on machine learning: a case study of Hongze Lake, China - Yun Luo; Zengchuan Dong; Yuhuan Liu; Xinkui Wang; Qingyi Shi; Yalei Han (Stochastic Environmental Research and Risk Assessment, 2021)

GmFULa improves soybean yield by enhancing carbon assimilation without altering flowering time or maturity - Yanlei Yue; Shi Sun; Jiawen Li; Haidong Yu; Hongxia Wu; Baiquan Sun; Tao Li; Tianfu Han; Bingjun Jiang (Plant Cell Reports, 2021)
Key message GmFULa improved soybean yield by enhancing carbon assimilation. Meanwhile, different from known yield-related genes, it did not alter flowering time or maturity. Abstract Soybean ( Glycine max (L.) Merr.) is highly demanded by a continuously growing human population. However, increasing soybean yield is a major challenge. FRUITFULL ( FUL ), a MADS-box transcription factor, plays important roles in multiple developmental processes, especially fruit and pod development, which are crucial for soybean yield formation. However, the functions of its homologs in soybean are not clear. Here, through haplotype analysis, we found that one haplotype of the soybean homolog GmFULa ( GmFULa-H02 ) is dominant in cultivated soybeans, suggesting that GmFULa-H02 was highly selected during domestication and varietal improvement of soybean. Interestingly, transgenic overexpression of GmFULa enhanced vegetative growth with more biomass accumulated and ultimately increased the yield but without affecting the plant height or changing the flowering time and maturity, indicating that it enhances the efficiency of dry matter accumulation. It also promoted the yield factors like branch number, pod number and 100-seed weight, which ultimately increased the yield. It increased the palisade tissue cell number and the chlorophyll content to promote photosynthesis and increase the soluble sugar content in leaves and fresh seeds. Furthermore, GmFULa were found to be sublocalized in the nucleus and positively regulate sucrose synthases ( SUSs ) and sucrose transporters ( SUTs ) by binding with the conserved CArG boxes in their promoters. Overall, these results showed GmFULa promotes the capacity of assimilation and the transport of the resultant assimilates to increase yield, and provided insights into the link between GmFULa and sucrose synthesis with transport-related molecular pathways that control seed yield.

mGluR5-Mediated eCB Signaling in the Nucleus Accumbens Controls Vulnerability to Depressive-Like Behaviors and Pain After Chronic Social Defeat Stress - Xiaotao Xu; Kaixuan Wu; Xiaqing Ma; Wenying Wang; Haiyan Wang; Min Huang; Limin Luo; Chen Su; Tifei Yuan; Haibo Shi; Ji Han; Aizhong Wang; et al. (Molecular Neurobiology, 2021)

Does renewable energy consumption contribute to the development of low-carbon economy? Evidence from China - Tuochen Li; Ziyi Shi; Dongri Han (Environmental Science and Pollution Research, 2021)

Near-field prediction of chemical hazard diffusion based on improved differential evolution algorithm and fireworks algorithm - Chaoshuai Han; Xuezheng Zhu; Jin Gu; Qinwen Zuo; Lin Chen; Yihao Shi (Environmental Monitoring and Assessment, 2021)

Low-Se Diet Can Affect Sperm Quality and Testicular Glutathione Peroxidase-4 activity in Rats - Qin Wang; Shuo Zhan; Yiqun Liu; Feng Han; Lili Shi; Chao Han; Weipeng Mu; Jizhong Cheng; Zhen-wu Huang (Biological Trace Element Research, 2021)

Stable isotopes (δ2H) in feathers identify non-breeding origins of the endangered Jankowski’s Bunting - Zheng Han; Hai-Tao Wang; Kevin J. Kardynal; Keith A. Hobson; Wei-Ping Shang; li-shi Zhang; Yun-lei Jiang; Frédéric Jiguet (Journal of Ornithology, 2021)

Responses of soil N 2 O emissions and their abiotic and biotic drivers to altered rainfall regimes and co‐occurring wet N deposition in a semi‐arid grassland - Yujie Shi; Junfeng Wang; Yunna Ao; Jiayu Han; Zhihan Guo; Xinyuan Liu; Jinwei Zhang; Chunsheng Mu; Xavier Le Roux (Global Change Biology, 2021)
Global change factors such as changed rainfall regimes and nitrogen (N) deposition contribute to increases in the emission of the greenhouse gas nitrous oxide (N 2 O) from the soil. In previous research, N deposition has often been simulated by using a single or a series of N addition events over the course of a year, but wet N deposition actually co‐occurs with rainfall. How soil N 2 O emissions respond to altered rainfall amount and frequency, wet N deposition, and their interactions is still not fully understood. We designed a three‐factor, fully factorial experiment with factors of rainfall amounts (ambient, −30%) rainfall frequency (ambient, ±50%) and wet N deposition (with/without) co‐occurring with rainfall in semi‐arid grassland mesocosms, and measured N 2 O emissions and their possible biotic and abiotic drivers. Across all treatments, reduced rainfall amount and N deposition increased soil N 2 O emissions by 35% and 28%, respectively. A significant interactive effect was observed between rainfall amount and N deposition, and to a lesser extent between rainfall frequency and N deposition. Without N deposition, reduced rainfall amount and altered rainfall frequency indirectly affected soil N 2 O emissions by changing the abundance of nirK and soil net N mineralization, and the changes in nirK abundance were indirectly driven by soil N availability rather than directly by soil moisture. With N deposition, both the abundance of nirK and the level of soil water‐filled pore space contributed to changes in N 2 O emissions in response to altered rainfall regimes, and the changes in the abundance of nirK were indirectly driven by plant N uptake and nitrifier (ammonia‐oxidizing bacteria) abundance. Our results imply that unlike wetter grassland ecosystems, reduced precipitation may increase N 2 O emissions, and N deposition may only slightly increase N 2 O emissions in arid and semi‐arid N‐limited ecosystems that are dominated by grasses with high soil N uptake capacity.

Differential DNA Methylation Profiles in Patients with Temporal Lobe Epilepsy and Hippocampal Sclerosis ILAE Type I - Wang Zhang; Haiyang Wang; Binchao Liu; Miaomiao Jiang; Yifei Gu; Shi Yan; Xian Han; Alicia Y. Hou; Chongyang Tang; Zhenfeng Jiang; Hong Shen; Meng Na; et al. (Journal of Molecular Neuroscience, 2021)

Methane Concentration in the Heartwood of Living Trees and Estimated Methane Emission on Stems in Upland Forests - Zhi-Ping Wang; Huan-Long Li; Hong-Hui Wu; Shi-Jie Han; Jian-Hui Huang; Xi-Mei Zhang; Xing-Guo Han (Ecosystems, 2021)

Identification and spatial pattern analysis of alpine timberline by remote sensing methods in Yarlung Zangpo Grand Canyon - Bei Zhu; Shi-yan Wang; Wei Su; Kai-qi Chen; Chang Liu; Yan-liang Du; Liang Wang; Zhen Han; Jiang-xiang Zou (Journal of Mountain Science, 2021)

The enhanced functional traits contribute to the successful invasion of Amaranthus palmeri in salinity environments: a comparison with its congeners - Tongtong Wang; Jianhua Han; Hongwen Fang; Amir Abdullah Khan; Lili Tang; Mei Zhang; Fuchen Shi (Biologia, 2021)

Inhibition of Ca2+-dependent protein kinase C rescues high calcium–induced pro-arrhythmogenic cardiac alternans in rabbit hearts - Pei-pei Zhang; Liangkun Hu; You-jia Tian; Zefu Zhang; Pei-hua Zhang; Yan-yan Yang; Shi-han Li; Jihua Ma (Pflügers Archiv - European Journal of Physiology, 2021)

Ferroptosis is involved in the development of neuropathic pain and allodynia - Huixing Wang; Xiaodong Huo; Chenyang Han; Jiang Ning; Hongguang Chen; Bo Li; Jingzhi Liu; Wenting Ma; Quanbo Li; Yonghao Yu; Kemei Shi (Molecular and Cellular Biochemistry, 2021)

Sum of High-Risk Gene Mutation (SHGM): A Novel Attempt to Assist Differential Diagnosis for Adrenocortical Carcinoma with Benign Adenoma, Based on Detection of Mutations of Nine Target Genes - Guo-Yang Zheng; Xue-Bin Zhang; Han-Zhong Li; Yu-Shi Zhang; Jian-Hua Deng; Xing-Cheng Wu (Biochemical Genetics, 2021)
There has been no research on applying gene detection to differential diagnosis of adrenocortical carcinoma (ACC). We attempted to explore a novel auxiliary method for differential diagnosis between ACC with benign adrenocortical adenoma (ACA), based on mutations of target genes in tissues. Nine genes were chosen as target genes, including TP53, CTNNB1, ARMC5, PRKAR1A, ZNRF3, RB1, APC, MEN1, and RPL22 . Exons sequencing of target genes were performed in 98 cases of tissue samples by FastTarget technology, including 41 ACC tissues, 32 ACA tissues, and 25 normal adrenal gland tissues. Significant mutations were detected and identified, and the clinical information was collected, for further comparative analysis and application to assist differential diagnosis of ACC. We identified 132 significant gene mutations and 227 significant mutation sites in 37 ACC tissues, much more than ACA and normal adrenal gland tissues. Mutation rates of 6 genes in ACC tissues were obviously higher than ACA tissues, including ZNRF3, ARMC5, TP53, APC, RB1, and PRKAR1A , regarded as high-risk genes. The sum of mutated high-risk genes detected in each sample was denominated sum of high-risk gene mutation (SHGM), and the rates of SHGM > 0 and SHGM > 1 in ACC tissues were 73.0% and 62.2%, respectively, both obviously higher than those in ACA tissues, with significant statistic differences. Especially for 8 cases of ACC with diameter 0 and SHGM > 1 were found in 6 samples (75%) and 4 samples (50%), respectively. However, no relevance was found between SHGM and clinical characteristics of ACC. We identified 6 high-risk genes in ACC tissues, with significantly higher mutation rates than ACA or normal adrenal gland tissues. The sum of mutated high-risk genes detected in ACC tissues was denominated SHGM, which was potential to assist the differential diagnosis of ACC with ACA, especially for the small-size ACC.

Geochronology and geochemistry of late Jurassic–Early Cretaceous volcanic rocks in the southern Great Xing’an range, NE China: constraints for late Mesozoic tectono-magmatic evolution - Shi-Jiong Han; Xi Wang; Xin Wang; Yan Wang; Yang Zhang (International Geology Review, 2021)

Intranasal oxytocin enhances the perception of ambiguous averted gaze in women but not in men - Ying Zheng; Yahuan Shi; Han Jia; Shan Gao; Zhonghua Hu (Psychopharmacology, 2021)

Autologous Transplantation for Parkinson's Disease Patients: Feasibility and Challenge - Qi Zhang; Yanlin Wang; Yukai Wang; Han Liu; Huifang Sun; Zhuoya Wang; Changhe Shi; Jing Yang; Yuming Xu (Neuroscience Bulletin, 2021)

Serum Iron and Ferritin Levels Are Correlated with Complement C3 - Shuang Wen; Yeqin Sha; Yinling Li; Zhilian Rui; Chenhong Si; Yuning Zhou; Fengfeng Yan; Bicheng Wang; Jingming Hu; Xu Han; Dongyan Shi (Biological Trace Element Research, 2021)

Inversion of the Degradation Coefficient of Petroleum Hydrocarbon Pollutants in Laizhou Bay - Shengmao Huang; Haiwen Han; Xiuren Li; Dehai Song; Wenqi Shi; Shufang Zhang; Xianqing Lv (Journal of Marine Science and Engineering, 2021)
When petroleum hydrocarbon pollutants enter the ocean, besides the migration under hydrodynamic constraints, their degradation due to environmental conditions also occurs. However, available observations are usually spatiotemporally disperse, which makes it difficult to study the degradation characteristics of pollutants. In this paper, a model of transport and degradation is used to estimate the degradation coefficient of petroleum hydrocarbon pollutants with the adjoint method. Firstly, the results of a comprehensive physical–chemical–biological test of the degradation of petroleum hydrocarbon pollutants in Laizhou Bay provide a reference for setting the degradation coefficient on the time scale. In ideal twin experiments, the mean absolute errors between observations and simulation results obtain an obvious reduction, and the given distributions can be inverted effectively, demonstrating the feasibility of the model. In a practical experiment, the actual distribution of petroleum hydrocarbon pollutants in Laizhou Bay is simulated, and the simulation results are in good agreement with the observed ones. Meanwhile, the spatial distribution of the degradation coefficient is inverted, making the simulation results closer to the actual observations.

Modeling canopy photosynthesis and light interception partitioning among shoots in bi-axis and single-axis apple trees (Malus domestica Borkh.) - Weiwei Yang; Xiaolong Ma; Doudou Ma; Jidong Shi; Sayed Hussain; Mingyu Han; Evelyne Costes; Dong Zhang (Trees, 2021)

Osteogenic Response of MC3T3-E1 and Raw264.7 in the 3D-Encapsulated Co-Culture Environment - Jungju Kim; Hao-Zhen Lyu; Chisung Jung; Kyung Mee Lee; Shi Huan Han; Jae Hyup Lee; Misun Cha (Tissue Engineering and Regenerative Medicine, 2021)

Genetic Architecture of Childhood Kidney and Urological Diseases in China - Ye Fang; Hua Shi; Tianchao Xiang; Jiaojiao Liu; Jialu Liu; Xiaoshan Tang; Xiaoyan Fang; Jing Chen; Yihui Zhai; Qian Shen; Guomin Li; Li Sun; et al. (Phenomics, 2021)
Kidney disease is manifested in a wide variety of phenotypes, many of which have an important hereditary component. To delineate the genotypic and phenotypic spectrum of pediatric nephropathy, a multicenter registration system is being implemented based on the Chinese Children Genetic Kidney Disease Database (CCGKDD). In this study, all the patients with kidney and urological diseases were recruited from 2014 to 2020. Genetic analysis was conducted using exome sequencing for families with multiple affected individuals with nephropathy or clinical suspicion of a genetic kidney disease owing to early-onset or extrarenal features. The genetic diagnosis was confirmed in 883 of 2256 (39.1%) patients from 23 provinces in China. Phenotypic profiles showed that the primary diagnosis included steroid-resistant nephrotic syndrome (SRNS, 23.5%), glomerulonephritis (GN, 32.2%), congenital anomalies of the kidney and urinary tract (CAKUT, 21.2%), cystic renal disease (3.9%), renal calcinosis/stone (3.6%), tubulopathy (9.7%), and chronic kidney disease of unknown etiology (CKDu, 5.8%). The pathogenic variants of 105 monogenetic disorders were identified. Ten distinct genomic disorders were identified as pathogenic copy number variants (CNVs) in 11 patients. The diagnostic yield differed by subgroups, and was highest in those with cystic renal disease (66.3%), followed by tubulopathy (58.4%), GN (57.7%), CKDu (43.5%), SRNS (29.2%), renal calcinosis /stone (29.3%) and CAKUT (8.6%). Reverse phenotyping permitted correct identification in 40 cases with clinical reassessment and unexpected genetic conditions. We present the results of the largest cohort of children with kidney disease in China where diagnostic exome sequencing was performed. Our data demonstrate the utility of family-based exome sequencing, and indicate that the combined analysis of genotype and phenotype based on the national patient registry is pivotal to the genetic diagnosis of kidney disease.