Distribution of Coomassie Blue Stainable Particles in the Pearl River Estuary, China, Insight Into the Nitrogen Cycling in Estuarine System - Cui-Ci Sun; Wei-Zhong Yue; You-Shao Wang; Wei-Hong He; Yi-Guo Hong; Fu-Lin Sun; Hao Cheng; Mei-Lin Wu; Zhao-Yu Jiang; Fei Jiao; Yu-Tu Wang (Frontiers in Marine Science, 2022)
Distributions of Coomassie Blue stainable particles (CSP), the sources and transports, as well as their implications for nitrogen biogeochemical cycles in the Pearl River estuary (PRE) were investigated during two cruises in August 2016 and January 2017. CSP color concentrations (CSP concentration determined spectrophotometrically) were 73.7–685.3 μg BSA eq L –1 [μg Bovine serum albumin (BSA) equivalent liter –1 ] in August 2016 and 100.6–396.4 μg BSA eq L –1 in January 2017, respectively. CSP concentrations were high in low-salinity waters (<5), and declined from the river to the middle estuary by 80% in the wet season and 55.6% in the dry season, respectively, then increased again in the lower estuary due to high primary production. CSP concentrations were mainly associated with chlorophyll a (Chl a ) concentration except for the turbid mixing zone, suggesting that autochthonous phytoplankton production served as the primary source of CSP in the PRE. The concentrations of nitrogen (N) as CSP in the PRE were comparable to the nitrogen content of particulate hydrolysable amino acids (PHAA). Pictures of CSP taken by microscopy and the correlation between composition of PHAA and the ratio of Chl a /CSP color showed that CSP were relatively degraded due to delivery of old terrestrial protein to river section and extensive microbial degradation during mixing at the upper and middle parts of the estuary, whereas CSP in lower estuary appeared to be more labile due to higher fresh algal production. The contribution of CSP nitrogen (CSP-N) to the particulate nitrogen (PN) pool was 34.98% in summer and 30.8% in winter. The conservative estimate of CSP-N input flux in the Pearl River Delta was about 6 × 10 6 mol N d –1 . These results suggested that CSP was a significant pool of organic nitrogen in the PRE. The study of CSP composition in terms of nitrogen provides new insight into the roles of CSP on nitrogen biogeochemical processes in the turbid and productive estuarine system.

New species and new record of Alternaria from onion leaf blight in Myanmar - Aye Aye Htun; Hai Feng Liu; Lin He; Zhen Zhou Xia; Sein Lai Lai Aung; Jian Xin Deng (Mycological Progress, 2022)

The frequency of cannibalism by Spodoptera frugiperda larvae determines their probability of surviving food deprivation - Hualiang He; Ailin Zhou; Li He; Lin Qiu; Wenbing Ding; Youzhi Li (Journal of Pest Science, 2022)

Zeb2/Axin2-Enriched BMSC-Derived Exosomes Promote Post-Stroke Functional Recovery by Enhancing Neurogenesis and Neural Plasticity - Rui Wei; Lin Zhang; Wei Hu; Xinying Shang; Yuyan He; Wei Zhang (Journal of Molecular Neuroscience, 2022)

Air pollution increased risk of reproductive system diseases: a 5-year outcome analysis of different pollutants in different seasons, ages, and genders - Ya Li; Juan Du; Shanshan Lin; Huihui He; Rui Jia; Weihong Liu (Environmental Science and Pollution Research, 2022)

Pharmaceuticals in drinking water sources and tap water in a city in the middle reaches of the Yangtze River: occurrence, spatiotemporal distribution, and risk assessment - Peng He; Junmei Wu; Jingqian Peng; Lin Wei; Liping Zhang; Qiaohong Zhou; Zhenbin Wu (Environmental Science and Pollution Research, 2022)

Molecular Mechanism of Aluminum-Induced Oxidative Damage and Apoptosis in Rat Cardiomyocytes - LiuFang Zhou; Mingjie He; XiaoLan Li; Erbing Lin; YingChuan Wang; Hua Wei; Xi Wei (Biological Trace Element Research, 2022)

Productivity calculating method in tight gas reservoirs considering the stress sensitivity - Jie He; Xiangdong Guo; Hongjun Cui; Kaiyu Lei; Yanyun Lei; Lin Zhou; Qinghai Liu; Yushuang Zhu; Linyu Liu (Arabian Journal of Geosciences, 2022)

Responses of soil pH to no‐till and the factors affecting it: A global meta‐analysis - Xin Zhao; Cong He; Wen‐Sheng Liu; Wen‐Xuan Liu; Qiu‐Yue Liu; Wei Bai; Li‐Jun Li; Rattan Lal; Hai‐Lin Zhang (Global Change Biology, 2022)
No‐till (NT) is a sustainable option because of its benefits in controlling erosion, saving labor, and mitigating climate change. However, a comprehensive assessment of soil pH response to NT is still lacking. Thus, a global meta‐analysis was conducted to determine the effects of NT on soil pH and to identify the influential factors and possible consequences based on the analysis of 114 publications. When comparing tillage practices, the results indicated an overall significant decrease by 1.33 ± 0.28% in soil pH under NT than that under conventional tillage ( p −1 (−1.83%), or crop residue retention (−1.52%). Changes in organic matter decomposition under undisturbed soil and with crop residue retention might lead to a higher concentration of H + and lower of basic cations (i.e., calcium, magnesium, and potassium), which decrease the soil pH, and consequently, impact nutrient dynamics (i.e., soil phosphorus) in the surface layer under NT. Furthermore, soil acidification may be aggravated by NT within site‐specific conditions and improper fertilizer and crop residue management and consequently leading to adverse effects on soil nutrient availability. Thus, there is a need to identify strategies to ameliorate soil acidification under NT to minimize the adverse consequences.

Bioactive compounds derived from the marine-derived fungus MCCC3A00951 and their influenza neuraminidase inhibition activity in vitro and in silico - Shun-Zhi Liu; Feng-Ming He; Yan-lin Bin; Chu-Fang Li; Bao-Ying Xie; Xi-Xiang Tang; Ying-Kun Qiu (Natural Product Research, 2021)

Species Composition and Assemblages of Ichthyoplankton in Sansha Bay, Fujian Province, China - Yan Jiang; Bai-an Lin; Hao-yang He; Guang-mao Ding; Li-ting Yan; Ge Zhang; Min Liu; Lian-ming Zheng (Frontiers in Marine Science, 2021)
Sansha Bay (26.40−27.00°N, 119.50−120.20°E) is a typical semi-enclosed bay, located in northern Fujian Province, China, and adjacent to the East China Sea. The ichthyoplankton species composition and assemblage structure were investigated based on monthly sampling at 25 stations in April−September 2019, covering the important spring and summer spawning seasons in the region. Sampling was conducted in the first 3−5 days of the full moon or new moon phases using a standard plankton net through horizontal and vertical tows during daytime. In total, 25,819 ichthyoplankton samples were collected, of which 25,449 samples (i.e., 24,757 eggs and 692 larvae) were from horizontal tows. For horizontal tow samples, the ichthyoplankton were classified into 58 taxa in 15 orders and 23 families with a combination of external morphology and DNA barcoding analyses, from pelagic to demersal and benthic species. The dominant order was the Gobiiformes, including 23 species (39.7% of all species). The dominant taxa, in terms of relative abundance and frequency of occurrence, consisted of commercially important fishes, such as Setipinna tenuifilis (Valenciennes, 1848) (Engraulidae), Epinephelus akaara (Temminck and Schlegel, 1842) (Serraenidae), Collichthys lucidus (Richardson, 1844), Nibea albiflora (Richardson, 1846) (Sciaenidae), Acanthopagrus schlegelii (Bleeker, 1854), and Pagrus major (Temminck and Schlegel, 1843) (Sparidae), accounting for 78.9% of the horizontal tow samples. Low-valued and small-sized fishes, such as Stolephorus commersonnii Lacepède, 1803 (Engraulidae), Solea ovata Richardson, 1846 (Soleidae), Nuchequula nuchalis (Temminck and Schlegel, 1845), and Photopectoralis bindus (Valenciennes, 1835) (Leiognathidae), were also dominant species, accounting for 11.4% of the horizontal tow samples. The ichthyoplankton assemblage was categorized into five different temporal assemblages based on the cluster and nonmetric multidimensional scaling analysis, namely, April, May, June, July, and August−September (ANOSIM, Global R = 0.656, p < 0.01) with the highest density and richness of ichthyoplankton occurred in May. The spatial distribution pattern showed that the high density (ind./m 3 ) of ichthyoplankton occurred mainly in S12–S25 in Guanjingyang and along the Dongchong Peninsula coastline into Dongwuyang, while low density occurred mainly in S01–S11 in the northwest waters of Sandu Island (ANOVA, F = 8.270, p < 0.05). Temperature, salinity, and chlorophyll a were key factors structuring the ichthyoplankton assemblages in Sansha Bay. In addition, this study revealed the changes of the ichthyoplankton composition, density, and spatial distribution in Sansha Bay over the past three decades.

A dice similarity measure for TBM penetrability classification in hard rock condition with the intuitionistic fuzzy information of rock mass properties - Rui Yong; Jun Ye; Shi-Gui Du; He Zhang; Leiyu Gu; Hang Lin (European Journal of Environmental and Civil Engineering, 2021)

Characterizing the Role of Glutamine synthetase Gene on Ammonia Nitrogen Detoxification Metabolism of the Razor Clam Sinonovacula constricta - Gaigai Sun; Changsen Sun; Jing He; Hanhan Yao; Wenfang Dai; Zhihua Lin; Yinghui Dong (Frontiers in Marine Science, 2021)
Ammonia nitrogen is a common toxic substance in the aquatic system, which seriously threatens the survival and growth of clams. However, less is known about the ammonia metabolism and detoxification strategy in razor clam. In this study, the polymorphism of the Glutamine synthetase gene from Sinonovacula constricta ( Sc-GS ) was found to be related to ammonia tolerance. By comparing the coding sequence (CDS) region of Sc-GS from two geographical populations, a total of 14 and 12 single nucleotide polymorphisms (SNPs) were identified, respectively, of which 10 loci were shared between the two populations. Among them, the locus c.1133T > G exhibited an extremely significant and strong association with ammonia tolerance in both populations ( P < 0.01), and it was missense mutation, which led to the amino acid change from leucine (Leu) to arginine (Arg). Furthermore, the results about H&E staining and immunohistochemistry of Sc-GS protein in gills and hepatopancreas revealed that it was specifically localized in the lateral cilia of gill filaments and the endothelial cells of hepatocytes. After inhibiting the Sc-GS expression by RNA interference (RNAi) technology, the transcript levels of Sc-GS were extremely significantly downregulated at 24, 48, 72, and 96 h ( P < 0.01) in the hepatopancreas. Taken together, these results indicated that the Sc-GS gene may participate in ammonia metabolism. In addition, these results will help to demonstrate the role of Sc-GS in ammonia nitrogen metabolism and provide markers related to ammonia nitrogen tolerance for molecular marker-assisted selection (MAS) of the razor clam.

Grafted PVDF Particles for Efficient Removal of Trace Lead (II) Ions in Aqueous Solution - Yihao Lei; Kaihao Jin; Xing Lin; Liyin He; Yinqiu Wu; Jianfeng Zhang (Water, Air, & Soil Pollution, 2021)

Histological alterations, oxidative stress, and inflammatory response in the liver of swamp eel (Monopterus albus) acutely exposed to copper - Lin Liu; Qiubai Zhou; Changgao Lin; Li He; Lili Wei (Fish Physiology and Biochemistry, 2021)

Effects of biochar on the growth of Vallisneria natans in surface flow constructed wetland - Chaoqun Zheng; Xuanwen Zhang; Lin Gan; Zhaofang He; Jinling Zhu; Wen Zhang; Yan Gao; Liuyan Yang (Environmental Science and Pollution Research, 2021)

Driving forces for recovery of forest vegetation after harvesting a subalpine oak forest in eastern Tibetan Plateau - Qinli Xiong; Lingjuan Li; Xiaojin Luo; Xingjin He; Lin Zhang; Kaiwen Pan; Chenggang Liu; Hui Sun (Environmental Science and Pollution Research, 2021)

Texture mapping of geological modeling based on parameterization - Lin Liu; Jianfeng He; Hongling Wang; Zhibo Wang (Earth Science Informatics, 2021)

Selenium-Alleviated Testicular Toxicity by Modulating Inflammation, Heat Shock Response, and Autophagy Under Oxidative Stress in Lead-Treated Chickens - Size Wang; Lulu Hou; Min Wang; Rui Feng; Xu Lin; Shifeng Pan; Qian Zhao; He Huang (Biological Trace Element Research, 2021)

Future study for the urinary histidine adduct derived from pyrrolizidine alkaloids is warranted - Lin Zhu; Chunyuan Zhang; Jiang Ma; Yisheng He; Ge Lin (Archives of Toxicology, 2021)

Termite mound formation reduces the abundance and diversity of soil resistomes - Zhen‐Zhen Yan; Qing‐Lin Chen; Chao‐Yu Li; Bao‐Anh Thi Nguyen; Yong‐Guan Zhu; Ji‐Zheng He; Hang‐Wei Hu (Environmental Microbiology, 2021)
Summary Termites are pivotal ecosystem engineers in tropical and subtropical habitats, where they construct massive nests (‘mounds’) that substantially modify soil properties and promote nutrient cycling. Yet, little is known about the roles of termite nesting activity in regulating the spread of antimicrobial resistance (AMR), one of the major Global Health challenges. Here, we conducted a large‐scale (> 1500 km) investigation in northern Australia and found distinct resistome profiles in termite mounds and bulk soils. By profiling a wide spectrum of ARGs, we found that the abundance and diversity of antibiotic resistance genes (ARGs) were significantly lower in termite mounds than in bulk soils ( P P

Precipitation increases the abundance of fungal plant pathogens in Eucalyptus phyllosphere - Qing‐Lin Chen; Hang‐Wei Hu; Zhen‐Zhen Yan; Chao‐Yu Li; Bao‐Anh Thi Nguyen; Yong‐Guan Zhu; Ji‐Zheng He (Environmental Microbiology, 2021)
Summary Understanding the current and future distributions of plant pathogens is critical to predict the plant performance and related economic benefits in the changing environment. Yet, little is known about the roles of environmental drivers in shaping the profiles of fungal plant pathogens in phyllosphere, an important habitat of microbiomes on Earth. Here, using a large‐scale investigation of Eucalyptus phyllospheric microbiomes in Australia and the multiple linear regression model, we show that precipitation is the most important predictor of fungal taxonomic diversity and abundance. The abundance of fungal plant pathogens in phyllosphere exhibited a positive linear relationship with precipitation. With this empirical dataset, we constructed current and future atlases of phyllosphere plant pathogens to estimate their spatial distributions under different climate change scenarios. Our atlases indicate that the abundance of fungal plant pathogens would increase especially in the coastal regions with up to 100‐fold increase compared with the current abundance. These findings advance our understanding of the distributions of fungal plant pathogens in phyllospheric microbiomes under the climate change, which can improve our ability to predict and mitigate their impacts on plant productivity and economic losses.

The ER membrane protein complex subunit Emc3 controls angiogenesis via the FZD4/WNT signaling axis - Mu Yang; Shujin Li; Wenjing Liu; Xiao Li; Yunqi He; Yeming Yang; Kuanxiang Sun; Lin Zhang; Wanli Tian; Lixin Duan; Huafu Chen; Dezhong Yao; et al. (Science China Life Sciences, 2021)

Dopaminergic Projection from Ventral Tegmental Area to Substantia Nigra Pars Reticulata Mediates Chronic Social Defeat Stress–Induced Hypolocomotion - Feng He; Pei Zhang; Qian Zhang; Guangjian Qi; Hongwei Cai; Tongxia Li; Ming Li; Jiazhen Lu; Jiaen Lin; Jie Ming; Bo Tian (Molecular Neurobiology, 2021)

A 168-year temperature recording based on tree rings and latitude differences in temperature changes in northeast China - Yangao Jiang; Yuting Cao; Junhui Zhang; Zhuo Li; Guoqiang Shi; Shijie Han; Cassius E. O. Coombs; Chuan Liu; Xiaoguang Wang; Junwei Wang; Lin Hao; Qi Xu; et al. (International Journal of Biometeorology, 2021)

Impact of climate change on alpine plant community in Qilian Mountains of China - Jun Du; Zhibin He; Longfei Chen; Pengfei Lin; Xi Zhu; Quanyan Tian (International Journal of Biometeorology, 2021)

Untargeted metabolomic analysis of urine samples for diagnosis of inherited metabolic disorders - Hao Liu; Jiang Zhu; Qiu Li; Dongjuan Wang; Kexing Wan; Zhaojian Yuan; Juan Zhang; Lin Zou; Xiaoyan He; Jingkun Miao (Functional & Integrative Genomics, 2021)

Cardiovascular safety of long-term anti-obesity drugs in subjects with overweight or obesity: a systematic review and meta-analysis - Lin Zhang; Zhi Liu; Shenling Liao; He He; Mei Zhang (European Journal of Clinical Pharmacology, 2021)

Development and validation of gene-specific KASP markers for YrAS2388R conferring stripe rust resistance in wheat - Yanling Hu; Xuhui Huang; Fang Wang; Yu He; Lihua Feng; Bo Jiang; Ming Hao; Shunzong Ning; Zhongwei Yuan; Jiajie Wu; Lianquan Zhang; Bihua Wu; et al. (Euphytica, 2021)

Thermal treatment’s enhancement on high solid anaerobic digestion: effects of temperature and reaction time - Yuan Lin; Zuwen Liu; Yuying Hu; Fangyu He; Shi Yang (Environmental Science and Pollution Research, 2021)

Postnatal development of BAG3 expression in mouse cerebral cortex and hippocampus - Xinlu Li; Geng Lin; Tongtong Liu; Ning Zhao; He Xu; Huaqin Wang; Wei Zheng (Brain Structure and Function, 2021)

Streptomyces luteolifulvus sp. nov., a novel actinomycete isolated from soil in Nanjing, China - Shanshan Zhao; Ming Cheng; Congyu Lin; He Liu; Zhengran Wang; Kai Zhang; Simin Song; Qian Yang (Antonie van Leeuwenhoek, 2021)

Oceanic vertical mixing of the lower halocline water in the Chukchi Borderland and Mendeleyev Ridge - Long Lin; Hailun He; Yong Cao; Tao Li; Yilin Liu; Mingfeng Wang (Acta Oceanologica Sinica, 2021)

Local community assembly processes shape β‐diversity of soil phoD ‐harbouring communities in the Northern Hemisphere steppes - Lin Xu; Nianpeng He; Xiangzhen Li; Huili Cao; Chaonan Li; Ruili Wang; Changhui Wang; Minjie Yao; Shungui Zhou; Junming Wang (Global Ecology and Biogeography, 2021)
Aim The contemporary coexistence theory suggests that species pool, environmental filtering, dispersal assembly processes, ecological drift and biotic interactions collectively determine the β‐diversity of communities. However, we know little about the biogeographical patterns of the β‐diversity of microbial communities harbouring the alkaline phosphatase phoD gene ( phoD communities, hereafter) and whether these mechanisms are all‐important in shaping phoD communities’ β‐diversity in natural steppe ecosystems. Location Northern Hemisphere steppes. Time period July to August 2018. Major taxa studied Alkaline phosphatase ( phoD gene) encoding community. Methods Using the high throughput amplicon sequencing method, soil phoD communities were comparatively studied along three representative regions of the Northern Hemisphere steppes, namely the Qinghai‐Tibetan Plateau, Inner Mongolian Plateau and the Loess Plateau. Each region harbours three types of steppes (habitats): meadow, typical and desert steppes. Results We observed significantly higher phoD β‐diversity in the Qinghai‐Tibetan than in the Loess and Inner Mongolian Plateaus and significantly lower β‐diversity in the typical steppes than in other steppe types. The decay rates of phoD β‐diversity with geographical distance varied in different steppe regions and types. The phoD β‐diversity was not significantly influenced by species pool; instead, environmental filtering, dispersal assembly processes, ecological drift and biotic interactions jointly shaped the β‐diversity patterns. The β‐deviation variations (β‐diversity excluding the effects of species pool) were influenced by spatial and environmental factors and biotic interactions, among which soil pH was the key environmental determinant. The soil pH driving β‐diversity mechanism was steppe region and habitat specific. Main conclusions The biogeographical patterns of phoD β‐diversity were mainly driven by local community assembly processes in the Northern Hemisphere steppes.

Two new cephalochromin derivative from the Alternaria sp. ZG22 - Xin-Ming Song; Xue-Ming Zhou; Ya-Ling Li; Li-Bing Huang; Cai-Cui Chen; Yan Gao; Lin He; Xiao-qun Mao; Bing Chen; Jing-Wen Liu; Hui-Jie Liu; Xiao-Ping Song; et al. (Natural Product Research, 2021)

Artemisinin analogue SM934 protects against lupus-associated antiphospholipid syndrome via activation of Nrf2 and its targets - Zemin Lin; Yuting Liu; Li Chen; Shiqi Cao; Yueteng Huang; Xiaoqian Yang; Fenghua Zhu; Wei Tang; Shijun He; Jianping Zuo (Science China Life Sciences, 2021)

Complement C3 Aggravates Post-epileptic Neuronal Injury Via Activation of TRPV1 - Guang-Tong Jiang; Lin Shao; Shuo Kong; Meng-Liu Zeng; Jing-Jing Cheng; Tao-Xiang Chen; Song Han; Jun Yin; Wan-Hong Liu; Xiao-Hua He; Yu-Min Liu; Lanzi Gongga; et al. (Neuroscience Bulletin, 2021)

LINC00922 promotes the proliferation, migration, invasion and EMT process of liver cancer cells by regulating miR-424-5p/ARK5 - Zhiyu Ye; Qikuan He; Qiaona Wang; Yunshou Lin; Kenan Cen; Xiaogang Chen (Molecular and Cellular Biochemistry, 2021)

Effects of a compound microbial agent and plants on soil properties, enzyme activities, and bacterial composition of Pisha sandstone - Lin Deng; Tao Wang; Wei Luo; Linyan He; Zhishui Liang (Environmental Science and Pollution Research, 2021)

Fruit-Specific Expression of crtB, HpBHY, CrBKT and SlLCYB in a Special Tomato Landrace Triggers Hyper Production of Carotenoids in the Fruit - Yuanyuan Lin; Mingxia He; Jielin Wang; Junchao Huang (Journal of Plant Biology, 2021)

Transcriptome Analysis Provides New Insights into Host Response to Hepatopancreatic Necrosis Disease in the Black Tiger Shrimp Penaeus monodon - Jichen Zhao; Xieyan Chen; Zihao He; Guoliang Chen; Zhaojian Lin; Yongkui Liu; Chengbo Sun; Wei Wang (Journal of Ocean University of China, 2021)

Developing urinary pyrrole–amino acid adducts as non-invasive biomarkers for identifying pyrrolizidine alkaloids-induced liver injury in human - Lin Zhu; Chunyuan Zhang; Wei Zhang; Qingsu Xia; Jiang Ma; Xin He; Yisheng He; Peter P. Fu; Wei Jia; Yuzheng Zhuge; Ge Lin (Archives of Toxicology, 2021)

Microorganism and Physiochemical Characteristic of High-salt (Suan Yu), a Traditional Chinese Fermented Fish - Chengxing Lin; Furong Zhang; Qin Yang; Ju Meng; Laping He; Li Deng; Chun Ye; Xuefeng Zeng (Journal of Aquatic Food Product Technology, 2021)

Experimental study on integrated and autonomous conductivity-temperature-depth (CTD) sensor applied for underwater glider - Bin Lv; Hai-lin Liu; Yi-fan Hu; Cheng-xuan Wu; Jie Liu; Hai-jing He; Jie Chen; Jian Yuan; Zhao-wen Zhang; Lin Cao; Hui Li (Marine Georesources & Geotechnology, 2021)

In silico design of antimicrobial oligopeptides based on 3D-QSAR modeling and bioassay evaluation - Guangping Li; Yuxuan Wang; Yan Shen; Haiqiong Guo; Qingxiu He; Yong Hu; Haibin Liu; Zhihua Lin; Yuanqiang Wang (Medicinal Chemistry Research, 2021)

Skvortzovia yunnanensis, a new species of corticioid fungus from southern China - Jun-Hong Dong; Xiao He; Chang-Lin Zhao (Kew Bulletin, 2021)

Integration of small RNAs, degradome, and transcriptome sequencing provides insights into the differences between Shizhu ginseng and Yuan ginseng - Mengyuan Peng; Yanlin Chen; Wenjuan Wang; Zhihua He; Wangqiang Dai; Zhiyun Lin; Zemin Yang; Mengjuan Gong; Yongqin Yin; Bin Han; Yu Zeng; Yingfang Wang (Journal of Plant Biochemistry and Biotechnology, 2021)
Panax ginseng is one of the most popular herbs which have been used as an important traditional Chinese medicine since ancient times. Yuan ginseng and Shizhu ginseng,which belong to P. ginseng , are widely used as substitutes for wild ginseng in clinical practice. Clinical practice has proved that the clinical efficacy of Shizhu ginseng is better than Yuan ginseng. However, current research cannot completely explain this phenomenon. Considering that small RNA may be one of the pharmacodynamic substances of P. ginseng , it is challenging to investigate differential miRNAs between Shizhu ginseng and Yuan ginseng. In this study, the transcriptome, small RNAome and degradome of P. ginseng were studied by high-throughput sequencing. A total of 63,875 unigenes and 43,950,137 small RNA clean reads were obtained from the roots of P. ginseng . Among 3206 differentially expressed genes, 1190 genes were up-regulated in Yuan ginseng when compared with Shizhu ginseng. 24 known differential miRNAs and 7 novel differential miRNAs were obtained. The 304 targets of 24 differentially expressed miRNA (17 known and 7 novel) families are mainly related to energy metabolism, biotic stress and disease immunity in ginseng itself. Through the association analysis of mRNA and miRNA, our work gives a better understanding of the difference between Yuan ginseng and Shizhu ginseng. Considering the cross-kingdom regulation of plant miRNAs, our results may provide a foundation for understanding the miRNA-dependent clinical efficacy in P. ginseng .

An eco‐city design methodology for hilly areas of western China - Kai Lin; Zhengwei He; Zhujun Zhao; Jiaxin Chang; Keran Tang; Rui Qu; Li He (Earth Science Informatics, 2021)

Effects of Polychlorinated Biphenyls on Animal Reproductive Systems and Epigenetic Modifications - Qi-Long He; Lin Zhang; Shu-Zhen Liu (Bulletin of Environmental Contamination and Toxicology, 2021)

Protective effect of Bombyx mori gloverin on intestinal epithelial cells exposure to enterotoxigenic E. coli - Qian Lin; Qingqing Fu; Guoqi Su; Daiwen Chen; Bing Yu; Yuheng Luo; Ping Zheng; Xiangbing Mao; Zhiqing Huang; Jie Yu; Junqiu Luo; Hui Yan; et al. (Brazilian Journal of Microbiology, 2021)

Taxonomic description of Pseudomonas rhizovicinus sp. nov., isolated from the rhizosphere of a desert shrub Haloxylon ammodendron - Ao-Lei He; Hui-Ru Li; Hui-Ping Li; Jing-Yi Gou; Jia Chen; Qi Zhao; Jin-Lin Zhang (Antonie van Leeuwenhoek, 2021)

Ethylene‐regulated leaf lifespan explains divergent responses of plant productivity to warming among three hydrologically different growing seasons - Haiyan Ren; Guodong Han; Mai‐He Li; Cuiping Gao; Lin Jiang (Global Change Biology, 2021)
Leaf senescence is known to be regulated by the plant hormone ethylene, but how leaf lifespan responds to global environmental change and links to ecosystem‐level responses remains largely unexplored. Here we investigated the effects of climate warming and nitrogen addition on plant functional traits, plant hormone ethylene and net primary production in a 13‐year field experiment in a desert steppe. Across the last 3 years of the experiment (2016–2018), plant productivity increased under warming only in 2016, when there was above normal precipitation, but consistently increased with nitrogen addition. Warming enhanced net photosynthesis, leaf nitrogen and ethylene production and reduced leaf lifespan in 2016 (a wet year), but not in 2017 (a drought year); the effect of warming in 2018 (a year with normal precipitation) was opposite to 2016, likely due to the below‐normal precipitation in the mid‐growing season in 2018. Nitrogen addition led to increases in leaf nitrogen, ethylene production and net photosynthesis, and declines in leaf lifespan in 2016 and 2018, but not in 2017. The ethylene‐regulated lifespan was further evidenced by the addition of CoCl 2 (an ethylene biosynthesis inhibitor) that reduced ethylene production and prolonged lifespan. Structural equation modeling showed that leaf lifespan had a negative effect on plant productivity, both directly and indirectly via its negative effect on net photosynthesis, across all 3 years. Our results demonstrate the divergent responses of leaf lifespan and, in turn, plant productivity to warming under inter‐annual and intra‐annual precipitation variation, thus linking plant hormone production, functional traits and ecosystem functioning in the face of global environmental change.

Gonad Transcriptome Analysis of the Razor Clam (Sinonovacula constricta) Revealed Potential Sex-Related Genes - Hanhan Yao; Zhihua Lin; Yinghui Dong; Xianghui Kong; Lin He; Liangyi Xue (Frontiers in Marine Science, 2021)
The razor clam, Sinonovacula constricta is a commercially important bivalve in the western Pacific Ocean, yet little is known about the mechanisms of sex determination/differentiation and gametogenesis. In the present study, the comparative transcriptome analysis of adult gonads (female gonads and male gonads) was conducted to identify potential sex-related genes in S. constricta . The number of reads generated for each target library (three females and three males) ranged from 31,853,422 to 37,750,848, and 20,489,472 to 26,152,448 could be mapped to the reference genome of S. constricta (the map percentage ranging from 63.71 to 71.48%). A total of 8,497 genes were identified to be differentially expressed between the female and male gonads, of which 4,253 were female-biased (upregulated in females), and 4,244 were male-biased. Forty-five genes were identified as potential sex-related genes, including DmrtA2 , Sox9 , Fem-1b , and Fem-1c involved in sex determination/differentiation and Vg, CYP17A1 , SOHLH2 , and TSSK involved in gametogenesis. The expression profiles of 12 genes were validated by qRT-PCR, which further confirmed the reliability and accuracy of the RNA-Seq results. Our results provide basic information about the genes involved in sex determination/differentiation and gametogenesis, and pave the way for further studies on reproduction and breeding in S. constricta and other marine bivalves.

Elevated pCO2 Impedes Succession of Phytoplankton Community From Diatoms to Dinoflagellates Along With Increased Abundance of Viruses and Bacteria - Ruiping Huang; Jiazhen Sun; Yunlan Yang; Xiaowen Jiang; Zhen Wang; Xue Song; Tifeng Wang; Di Zhang; He Li; Xiangqi Yi; Shouchang Chen; Nanou Bao; et al. (Frontiers in Marine Science, 2021)
Eutrophic coastal regions are highly productive and greatly influenced by human activities. Primary production supporting the coastal ecosystems is supposed to be affected by progressive ocean acidification driven by increasing CO 2 emissions. In order to investigate the effects of high p CO 2 (HC) on eutrophic plankton community structure and ecological functions, we employed 9 mesocosms and carried out an experiment under ambient (∼410 ppmv) and future high (1000 ppmv) atmospheric p CO 2 conditions, using in situ plankton community in Wuyuan Bay, East China Sea. Our results showed that HC along with natural seawater temperature rise significantly boosted biomass of diatoms with decreased abundance of dinoflagellates in the late stage of the experiment, demonstrating that HC repressed the succession from diatoms to dinoflagellates, a phenomenon observed during algal blooms in the East China Sea. HC did not significantly influence the primary production or biogenic silica contents of the phytoplankton assemblages. However, the HC treatments increased the abundance of viruses and heterotrophic bacteria, reflecting a refueling of nutrients for phytoplankton growth from virus-mediated cell lysis and bacterial degradation of organic matters. Conclusively, our results suggest that increasing CO 2 concentrations can modulate plankton structure including the succession of phytoplankton community and the abundance of viruses and bacteria in eutrophic coastal waters, which may lead to altered biogeochemical cycles of carbon and nutrients.

Geographic modeling and simulation systems for geographic research in the new era: Some thoughts on their development and construction - Min Chen; Guonian Lv; Chenghu Zhou; Hui Lin; Zaiyang Ma; Songshan Yue; Yongning Wen; Fengyuan Zhang; Jin Wang; Zhiyi Zhu; Kai Xu; Yuanqing He (Science China Earth Sciences, 2021)
Regionality, comprehensiveness, and complexity are regarded as the basic characteristics of geography. The exploration of their core connotations is an essential way to achieve breakthroughs in geography in the new era. This paper focuses on the important method in geographic research: Geographic modeling and simulation. First, we clarify the research requirements of the said three characteristics of geography and its potential to address geo-problems in the new era. Then, the supporting capabilities of the existing geographic modeling and simulation systems for geographic research are summarized from three perspectives: Model resources, modeling processes, and operational architecture. Finally, we discern avenues for future research of geographic modeling and simulation systems for the study of regional, comprehensive and complex characteristics of geography. Based on these analyses, we propose implementation architecture of geographic modeling and simulation systems and discuss the module composition and functional realization, which could provide theoretical and technical support for geographic modeling and simulation systems to better serve the development of geography in the new era.

Quantity of supplementary LED lightings regulates photosynthetic apparatus, improves photosynthetic capacity and enhances productivity of Cos lettuce grown in a tropical greenhouse - Jie He; Nur Khairunnisa Bte Jawahir; Lin Qin (Photosynthesis Research, 2021)

Associations of Sleep Characteristics with Cerebrospinal Fluid sTREM2 in Cognitively Normal Older Adults: the CABLE Study - He-Ying Hu; Ling-Zhi Ma; Hao Hu; Yan-Lin Bi; Ya-Hui Ma; Xue-Ning Shen; Ya-Nan Ou; Qiang Dong; Lan Tan; Jin-Tai Yu (Neurotoxicity Research, 2021)

Refractory organic compounds in coal chemical wastewater treatment by catalytic ozonation using Mn-Cu-Ce/Al2O3 - Kang-He Zhao; Yu-Long Ma; Feng Lin; Shao-Ying Ge; Li Zhu (Environmental Science and Pollution Research, 2021)

Identification of a delayed leaf greening gene from a mutation of pummelo - Hui-Wen Yu; Zhi-Hao Lu; Xia Wang; Dan Liu; Jia-Xian He; Xiao-Lin Jiang; Ling-Jun Ke; Wen-Wu Guo; Xiu-Xin Deng; Qiang Xu (Science China Life Sciences, 2021)

TRPV4 Regulates Soman-Induced Status Epilepticus and Secondary Brain Injury via NMDA Receptor and NLRP3 Inflammasome - Shuai Wang; Huanhuan He; Jianhai Long; Xin Sui; Jun Yang; Guodong Lin; Qian Wang; Yongan Wang; Yuan Luo (Neuroscience Bulletin, 2021)

Design, synthesis, and antidepressant/anticonvulsant activities of 3H-benzo[f]chromen chalcone derivatives - Qiu-Wan Tan; Li-Ya He; Zhi-Wen He; Wei-Hua Liu; Shan-Shan Zhang; Lin Lin; Hong-Li Yang; Li-Ping Guan (Medicinal Chemistry Research, 2021)

Phytoavailability, translocation and soil thresholds derivation of cadmium for food safety through soil-wheat (Triticum aestivum L.) system - Min Lu; Xuerui Cao; Qiang Lin; Bilal Hussain; Ying Feng; Zhenli He; Kyong Ju Kang; Xiaoe Yang (Environmental Science and Pollution Research, 2021)

Eco-efficiency evaluation model: a case study of the Yangtze River Economic Belt - Xu Xu; Lin-Chao Pan; Qing-He Ni; Qian-Qian Yuan (Environmental Monitoring and Assessment, 2021)

Seismic performance of precast bridge columns connected with grouted corrugated-metal duct through biaxial quasi-static experiment and modeling - Xia Zhanghua; Lin Shangshun; He Yongbo; Ge Jiping; Sun Jinlei (Earthquake Engineering and Engineering Vibration, 2021)

Above‐ and belowground biodiversity jointly drive ecosystem stability in natural alpine grasslands on the Tibetan Plateau - Litong Chen; Lin Jiang; Xin Jing; Jiuluan Wang; Yu Shi; Haiyan Chu; Jin‐Sheng He (Global Ecology and Biogeography, 2021)
Aim Most existing studies that examined the biotic mechanisms of ecosystem stability have focused on aboveground biodiversity. Whether and how belowground biodiversity affects the stability of natural ecosystems is largely unknown. In the present study, we investigated the relationships between above‐ and belowground biodiversity and the temporal stability of grassland biomass production across a large gradient of soil and climatic conditions. Location Tibetan Plateau. Time period 2001–2016. Major taxa studied Alpine grass and soil bacteria, arbuscular mycorrhiza (AM) fungi and fauna. Methods We coupled a field biodiversity survey conducted in 54 alpine grassland ecosystems across the Tibetan Plateau with a satellite‐sensed proxy (enhanced vegetation index, EVI) of ecosystem productivity during 2001–2016. The temporal stability of primary productivity was calculated as the ratio of the mean annual peak EVI to the standard deviation of the annual peak EVI over this period. Plant diversity was determined using a classic vegetation survey approach, soil bacterial and AM fungal diversity were measured using a high‐throughput sequencing approach, and soil fauna was counted and identified at the order level after being extracted using a modified Berlese–Tullgren method. Results Our results demonstrated that both above‐ and belowground biodiversity were positively associated with ecosystem stability. Belowground biodiversity not only affected ecosystem stability directly, but also influenced it indirectly through plant diversity and soil fertility. Furthermore, soil pH, climate and its variability strongly influenced soil biodiversity, which in turn influenced ecosystem stability. Main conclusions Our study demonstrates the indispensable role of belowground biodiversity in regulating ecosystem stability, emphasizing the necessity of conserving this ‘hidden’ biodiversity in fragile alpine ecosystems facing ongoing environmental change.

Flavonoids from Artemisia rupestris and their synergistic antibacterial effects on drug-resistant Staphylococcus aureus - Jiang-Er Lan; Xiao-Jin Li; Xiao-Feng Zhu; Zhong-Lin Sun; Jian-Ming He; Mire Zloh; Simon Gibbons; Qing Mu (Natural Product Research, 2021)

A survey of chloramphenicol residues in aquatic products of Shenzhen, South China - Lan Luo; Shaoyou Lu; Chengpeng Huang; Fu Wang; Yan Ren; He Cao; Qihui Lin; Zhiqiang Tan; Xiaodong Wen (Food Additives & Contaminants: Part A, 2021)

Biochar Alters Inorganic Phosphorus Fractions in Tobacco-growing Soil - Wenli Zhang; Caibin Li; Guitong Li; Qimei Lin; Xiaorong Zhao; Yi He; Yanxiang Liu; Zhenbao Luo (Journal of Soil Science and Plant Nutrition, 2021)

Monitoring and prediction of dust concentration in an open-pit mine using a deep-learning algorithm - Lin Li; Ruixin Zhang; Jiandong Sun; Qian He; Lingzhen Kong; Xin Liu (Journal of Environmental Health Science and Engineering, 2021)

Enhanced treatment of shale gas fracturing waste fluid through plant-microbial synergism - Bo Shao; Xu Tan; Ju-Long Li; Mei He; Lei Tian; Wen-Jie Chen; Yan Lin (Environmental Science and Pollution Research, 2021)

Icaritin Inhibits Skin Fibrosis through Regulating AMPK and Wnt/β-catenin Signaling - Ming Li; Qingmei Liu; Shan He; Xiangzhen Kong; Jinpei Lin; Yan Huang; Wenyu Wu; Jinfeng Wu (Cell Biochemistry and Biophysics, 2021)

Correction to: Synthetic antimicrobial agents inhibit aflatoxin production - Jing Li; Qing-Qing Zhi; Jie Zhang; Xiao-Yu Yuan; Li-Hong Jia; Yu-Lin Wan; Qiu-Yun Liu; Jian-Rong Shi; Zhu-Mei He (Brazilian Journal of Microbiology, 2021)

Synthetic antimicrobial agents inhibit aflatoxin production - Jing Li; Qing-Qing Zhi; Jie Zhang; Xiao-Yu Yuan; Li-Hong Jia; Yu-Lin Wan; Qiu-Yun Liu; Jian-Rong Shi; Zhu-Mei He (Brazilian Journal of Microbiology, 2021)

Nanoselenium and Selenium Yeast Have Minimal Differences on Egg Production and Se Deposition in Laying Hens - Tian-Tian Meng; Xue Lin; Chun-Yan Xie; Jian-Hua He; Yang-Kui Xiang; Yi-Qiang Huang; Xin Wu (Biological Trace Element Research, 2021)

Ghrelin Affects Gastric Cancer Progression by Activating AMPK Signaling Pathway - Xiao-Lin Hu; Yong-Jun Zhu; Chang-Hua Hu; Li You; Juan Wu; Xiao-Yan He; Wen-Jie Huang; Zong-Hui Wu (Biochemical Genetics, 2021)

Complete genome sequence of a previously undescribed monopartite begomovirus and betasatellite infecting Malvastrum coromandelianum in Cambodia - Yafei Tang; Zhenggang Li; Xiaoman She; Lin Yu; Guobing Lan; Lihua Lv; Judith K. Brown; Zifu He (Archives of Virology, 2021)

Metabolism-mediated cytotoxicity and genotoxicity of pyrrolizidine alkaloids - Yisheng He; Lin Zhu; Jiang Ma; Ge Lin (Archives of Toxicology, 2021)

Comprehensive evaluation of ecosystem services for brownfield redevelopment in Changsha - Yang Lin; Biao Wu; Deming Wang; Wei Xiao; Yihe Huang; Sijia Fu; Yuxuan He (Arabian Journal of Geosciences, 2021)

New insights into the fine-scale history of western–eastern admixture of the northwestern Chinese population in the Hexi Corridor via genome-wide genetic legacy - Hongbin Yao; Mengge Wang; Xing Zou; Yingxiang Li; Xiaomin Yang; Ailin Li; Hui-Yuan Yeh; Peixin Wang; Zheng Wang; Jingya Bai; Jianxin Guo; Jinwen Chen; et al. (Molecular Genetics and Genomics, 2021)

Stoichiometric relations of C, N, and P in urban top soils in Nanjing, China, and their biogeochemical implications - Jin-Ling Yang; Da-Gang Yuan; Yu-Guo Zhao; Yue He; Gan-Lin Zhang (Journal of Soils and Sediments, 2021)

Defense responses of sulfur dioxygenase to sulfide stress in the razor clam Sinonovacula constricta - Caifang Chen; Yaoyao Shen; Weiliang Shen; Jing He; Zhihua Lin; Yinghui Dong (Genes & Genomics, 2021)

Genome sequencing and functional annotation of Bacillus sp. strain BS-Z15 isolated from cotton rhizosphere soil having antagonistic activity against Verticillium dahliae - Zhong-Yi Chen; Xieerwanimu Abuduaini; Nuramina Mamat; Qi-Lin Yang; Meng-Jun Wu; Xin-Rui Lin; Ru Wang; Rong-Rong Lin; Wei-Jun Zeng; Huan-Chen Ning; He-Ping Zhao; Jin-Yu Li; et al. (Archives of Microbiology, 2021)

Geological and climatic histories likely shaped the origins of terrestrial vertebrates endemic to the Tibetan Plateau - Jiekun He; Siliang Lin; Chenchen Ding; Jiehua Yu; Haisheng Jiang (Global Ecology and Biogeography, 2021)
Aim The Tibetan Plateau (TP) hosts many endemic species, but questions regarding when and from where these species originated have not been comprehensively answered. Here, we provide a synthesis of the biogeographical history of terrestrial vertebrates endemic to the TP and investigate the potential drivers of their spatio‐temporal origins. Location Tibetan Plateau and its surrounding regions. Time period Cenozoic. Major taxa studied Terrestrial vertebrates. Methods We used dispersal–extinction–cladogenesis models based on time‐calibrated phylogenies to reconstruct the ancestral ranges of 174 endemic TP species and compiled the ancestral ranges and age estimates of their dispersal events. We generated a possibility map of source areas for endemic TP species by counting the incidence of non‐TP sister clades in 110 km × 110 km grid cells. We used generalized linear mixed models to assess the relative importance of historical processes and environmental factors in explaining the geographical variations in the source areas. We created subsets based on four vertebrate classes to test whether the dispersal events varied spatially and temporally among taxonomic groups. Results We found that the endemic species colonized the TP as early as 55 Ma, and that the main colonization phase started to increase around 15 Ma and peaked after 6 Ma. The major source areas of endemic TP species include the Hengduan Mountains, the Himalayas, and Central Asia. Elevation difference had the strongest effect on the source areas, followed by geographical distance. The spatio‐temporal origins of species endemic to the TP and the potential drivers showed significant differences among vertebrate classes. Main conclusions Our study supports the hypothesis that endemic TP species originated from various zoogeographical regions at different times and highlights the important roles of the TP uplift and past climatic changes for determining the spatio‐temporal origins of endemic TP species.

Microbial transformation of distinct exogenous substrates into analogous composition of recalcitrant dissolved organic matter - Jie Lian; Xiaoxuan Zheng; Xiaocun Zhuo; Yi‐Lung Chen; Chen He; Qiang Zheng; Ta‐Hui Lin; Jia Sun; Weidong Guo; Quan Shi; Nianzhi Jiao; Ruanhong Cai (Environmental Microbiology, 2021)
Summary Oceanic dissolved organic matter (DOM) comprises a complex molecular mixture which is typically refractory and homogenous in the deep layers of the ocean. Though the refractory nature of deep‐sea DOM is increasingly attributed to microbial metabolism, it remains unexplored whether ubiquitous microbial metabolism of distinct carbon substrates could lead to similar molecular composition of refractory DOM. Here, we conducted microbial incubation experiments using four typically bioavailable substrates (L‐alanine, trehalose, sediment DOM extract, and diatom lysate) to investigate how exogenous substrates are transformed by a natural microbial assemblage. The results showed that although each‐substrate‐amendment induced different changes in the initial microbial assemblage and the amended substrates were almost depleted after 90 days of dark incubation, the bacterial community compositions became similar in all incubations on day 90. Correspondingly, revealed by ultra‐high resolution mass spectrometry, molecular composition of DOM in all incubations became compositionally consistent with recalcitrant DOM and similar toward that of DOM from the deep‐sea. These results indicate that while the composition of natural microbial communities can shift with substrate exposures, long‐term microbial transformation of distinct substrates can ultimately lead to a similar refractory DOM composition. These findings provide an explanation for the homogeneous and refractory features of deep‐sea DOM.

Termite mounds reduce soil microbial diversity by filtering rare microbial taxa - Qing‐Lin Chen; Hang‐Wei Hu; Zhen‐Zhen Yan; Chao‐Yu Li; Bao‐Anh Thi Nguyen; Yong Zheng; Yong‐Guan Zhu; Ji‐Zheng He (Environmental Microbiology, 2021)
Summary Termites are ubiquitous insects in tropical and subtropical habitats, and some of them construct massive nests (‘mounds’), which substantially promote substrate heterogeneity by altering soil properties. Yet, the role of termite nesting process in regulating the distribution and diversity of soil microbial communities remains poorly understood, which introduces uncertainty in predictions of ecosystem functions of termite mounds in a changing environment. Here, by using amplicon sequencing, we conducted a survey of 134 termite mounds across >1500 km in northern Australia and found that termite mounds significantly differed from bulk soils in the microbial diversity and community compositions. Compared with bulk soils, termite nesting process decreased the microbial diversity and the relative abundance of rare taxa. Rare taxa had a narrower habitat niche breadth than dominant taxa and might be easier to be filtered by the potential intensive microbial competition during the nesting processes. We further demonstrated that the shift in pH induced by termite nesting process was a major driver shaping the microbial community profiles in termite mounds. Together, our work provides novel evidence that termite nesting is an important process in regulating soil microbial diversity, which advances our understanding of the functioning of termite mounds.

Structure of SARS-CoV-2 main protease in the apo state - Xuelan Zhou; Fanglin Zhong; Cheng Lin; Xiaohui Hu; Yan Zhang; Bing Xiong; Xiushan Yin; Jinheng Fu; Wei He; Jingjing Duan; Yang Fu; Huan Zhou; et al. (Science China Life Sciences, 2021)

Human β-Defensin 118 Attenuates Escherichia coli K88–Induced Inflammation and Intestinal Injury in Mice - Qian Lin; Qingqing Fu; Xiang Li; Yuheng Luo; Junqiu Luo; Daiwen Chen; Xiangbing Mao; Bing Yu; Ping Zheng; Zhiqing Huang; Jie Yu; Hui Yan; et al. (Probiotics and Antimicrobial Proteins, 2021)

Protein kinase PpCIPK1 modulates plant salt tolerance in Physcomitrella patens - Fei Xiao; Xiaochuan Li; Jiaxian He; Jinfeng Zhao; Guochun Wu; Qianyuan Gong; Huapeng Zhou; Honghui Lin (Plant Molecular Biology, 2021)

Decoding Cortical Glial Cell Development - Xiaosu Li; Guoping Liu; Lin Yang; Zhenmeiyu Li; Zhuangzhi Zhang; Zhejun Xu; Yuqun Cai; Heng Du; Zihao Su; Ziwu Wang; Yangyang Duan; Haotian Chen; et al. (Neuroscience Bulletin, 2021)
Mouse cortical radial glial cells (RGCs) are primary neural stem cells that give rise to cortical oligodendrocytes, astrocytes, and olfactory bulb (OB) GABAergic interneurons in late embryogenesis. There are fundamental gaps in understanding how these diverse cell subtypes are generated. Here, by combining single-cell RNA-Seq with intersectional lineage analyses, we show that beginning at around E16.5, neocortical RGCs start to generate ASCL1 + EGFR + apical multipotent intermediate progenitors (MIPCs), which then differentiate into basal MIPCs that express ASCL1, EGFR, OLIG2, and MKI67. These basal MIPCs undergo several rounds of divisions to generate most of the cortical oligodendrocytes and astrocytes and a subpopulation of OB interneurons. Finally, single-cell ATAC-Seq supported our model for the genetic logic underlying the specification and differentiation of cortical glial cells and OB interneurons. Taken together, this work reveals the process of cortical radial glial cell lineage progression and the developmental origins of cortical astrocytes and oligodendrocytes.

Selective Ferroptosis Inhibitor Liproxstatin-1 Attenuates Neurological Deficits and Neuroinflammation After Subarachnoid Hemorrhage - Yang Cao; Yin Li; Chao He; Feng Yan; Jian-Ru Li; Hang-Zhe Xu; Jian-Feng Zhuang; Hang Zhou; Yu-Cong Peng; Xiong-Jie Fu; Xiao-Yang Lu; Yuan Yao; et al. (Neuroscience Bulletin, 2021)

Phylogeny and taxonomy of two new Alternaria (Ascomycota: Pleosporaceae) species in section Gypsophilae from China - Lin He; Hong Cheng; Aye Aye Htun; Hui Ge; Zhen Zhou Xia; Jian Wei Guo; Jian Xin Deng; Tao Du (Mycological Progress, 2021)

Exosomes with high level of miR-181c from bone marrow-derived mesenchymal stem cells inhibit inflammation and apoptosis to alleviate spinal cord injury - Meng Zhang; Lin Wang; Sihua Huang; Xijing He (Journal of Molecular Histology, 2021)

Glycogen synthase kinase-3β (GSK-3β) deficiency inactivates the NLRP3 inflammasome-mediated cell pyroptosis in LPS-treated periodontal ligament cells (PDLCs) - Xiaolu Zhang; Shan He; Wanyu Lu; Lijia Lin; Hui Xiao (In Vitro Cellular & Developmental Biology - Animal, 2021)

Cloning and characterization of rec8 gene in orange-spotted grouper (Epinephelus coioides) and Dmrt1 regulation of rec8 promoter activity - Qing Wang; Fangmei Lin; Qi He; Qifeng Huang; Xuzhuo Duan; Xiaochun Liu; Shiqiang Xiao; Huirong Yang; HuiHong Zhao (Fish Physiology and Biochemistry, 2021)

Screening of binding proteins that interact with two components of the HOG MAPK pathway by the yeast two-hybrid method in Colletotrichum siamense - Xiaomiao Liao; Xiping Long; Qiguang He; Miao Song; Xiao Li; Wenbo Liu; Yu Zhang; Chunhua Lin; Weiguo Miao (European Journal of Plant Pathology, 2021)

Correction to: Bio-electrospraying is a safe technology for delivering human adipose-derived stem cells - Chuan Ye; Zhixu He; Yunfeng Lin; Yi Zhang; Jin Tang; Bo Sun; Minxian Ma; Jielin Liu; Long Yang; Houxiang Ren; Baoping Zhao (Biotechnology Letters, 2021)

miR-23b Attenuates LPS-Induced Inflammatory Responses in Acute Lung Injury via Inhibition of HDAC2 - Zhi-Feng Luo; Xiang-Hui Jiang; Huan Liu; Li-Yuan He; Xiong Luo; Fu-Chun Chen; Yu-Lin Tan (Biochemical Genetics, 2021)

Fertilization alters protistan consumers and parasites in crop‐associated microbiomes - Anqi Sun; Xiao‐Yan Jiao; Qinglin Chen; Pankaj Trivedi; Zixin Li; Fangfang Li; Yong Zheng; Yongxin Lin; Hang‐Wei Hu; Ji‐Zheng He (Environmental Microbiology, 2021)
Summary Crop plants carry an enormous diversity of microbiota that provide massive benefits to hosts. Protists, as the main microbial consumers and a pivotal driver of biogeochemical cycling processes, remain largely understudied in the plant microbiome. Here, we characterized the diversity and composition of protists in sorghum leaf phyllosphere, and rhizosphere and bulk soils, collected from an 8‐year field experiment with multiple fertilization regimes. Phyllosphere was an important habitat for protists, dominated by Rhizaria, Alveolata and Amoebozoa. Rhizosphere and bulk soils had a significantly higher diversity of protists than the phyllosphere, and the protistan community structure significantly differed among the three plant–soil compartments. Fertilization significantly altered specific functional groups of protistan consumers and parasites. Variation partitioning models revealed that soil properties, bacteria and fungi predicted a significant proportion of the variation in the protistan communities. Changes in protists may in turn significantly alter the compositions of bacterial and fungal communities from the top‐down control in food webs. Altogether, we provide novel evidence that fertilization significantly affects the functional groups of protistan consumers and parasites in crop‐associated microbiomes, which have implications for the potential changes in their ecological functions under intensive agricultural managements.

Kidney function change after transcatheter aortic valve replacement in patients with diabetes and/or hypertension - Jiaqi Fan; Changjie Yu; Kaida Ren; Wanbing Lin; Stella Ng; Zexin Chen; Xinping Lin; Lihan Wang; Qifeng Zhu; Yuxin He; Jubo Jiang; Xianbao Liu; et al. (Journal of Zhejiang University-SCIENCE B, 2021)

Association of FMO3 rs1736557 polymorphism with clopidogrel response in Chinese patients with coronary artery disease - Kong-Xiang Zhu; Pei-Yuan Song; He-Li; Mu-Peng Li; Yin-xiao Du; Qi-lin Ma; Li-Ming Peng; Xiao-Ping Chen (European Journal of Clinical Pharmacology, 2021)

Fluorine enrichment of vegetables and soil around an abandoned aluminium plant and its risk to human health - Lingling He; Chenglong Tu; Shouyang He; Jiulai Long; Ya Sun; Yan Sun; Changhu Lin (Environmental Geochemistry and Health, 2021)

Model test on support scheme for carbonaceous slate tunnel in high geostress zone at high depth - Zhi-gang Tao; Shu-lin Ren; Gan Li; Hao-tian Xu; Sen-lin Luo; Man-chao He (Journal of Mountain Science, 2021)

Roles of FERONIA-like receptor genes in regulating grain size and quality in rice - Long Wang; Dandan Wang; Zhuhong Yang; Shun Jiang; Jianing Qu; Wei He; Zhenming Liu; Junjie Xing; Youchu Ma; Qinlu Lin; Feng Yu (Science China Life Sciences, 2021)

Comparative analysis of developing grain transcriptome reveals candidate genes and pathways improving GPC in wheat lines derived from wild emmer - Fangyi Gong; Lin Huang; Tiangang Qi; Guan Tang; Jia Liu; Lan Xiang; Jingshu He; Youliang Zheng; Dengcai Liu; Bihua Wu (Journal of Applied Genetics, 2021)

Assisted selection of eating quality progeny of indica (O. sativa L. ssp. indica) and japonica (O. sativa L. ssp. japonica) hybrids using rice starch properties - Ting Mao; Zhan Zhang; Shan Jun Ni; Yi Zhou Zhao; Xin Li; Li Li Zhang; Yan Liu; Cheng Shun Zhong; He Huang; Shao Lin Wang; Xu Li (Genetic Resources and Crop Evolution, 2021)

Clinical application of pyrrole–hemoglobin adducts as a biomarker of pyrrolizidine alkaloid exposure in humans - Jiang Ma; Wei Zhang; Yisheng He; Lin Zhu; Chunyuan Zhang; Jia Liu; Yang Ye; Yuzheng Zhuge; Ge Lin (Archives of Toxicology, 2021)

CAS-ESM2.0 Model Datasets for the CMIP6 Flux-Anomaly-Forced Model Intercomparison Project (FAFMIP) - Jiangbo Jin; He Zhang; Xiao Dong; Hailong Liu; Minghua Zhang; Xin Gao; Juanxiong He; Zhaoyang Chai; Qingcun Zeng; Guangqing Zhou; Zhaohui Lin; Yi Yu; et al. (Advances in Atmospheric Sciences, 2021)
The second version of the Chinese Academy of Sciences Earth System Model (CAS-ESM2.0) is participating in the Flux-Anomaly-Forced Model Intercomparison Project (FAFMIP) experiments in phase 6 of the Coupled Model Intercomparison Project (CMIP6). The purpose of FAFMIP is to understand and reduce the uncertainty of ocean climate changes in response to increased CO 2 forcing in atmosphere-ocean general circulation models (AOGCMs), including the simulations of ocean heat content (OHC) change, ocean circulation change, and sea level rise due to thermal expansion. FAFMIP experiments (including faf-heat, faf-stress, faf-water, faf-all, faf-passiveheat, faf-heat-NA50pct and faf-heat-NA0ct) have been conducted. All of the experiments were integrated over a 70-year period and the corresponding data have been uploaded to the Earth System Grid Federation data server for CMIP6 users to download. This paper describes the experimental design and model datasets and evaluates the preliminary results of CAS-ESM2.0 simulations of ocean climate changes in the FAFMIP experiments. The simulations of the changes in global ocean temperature, Atlantic Meridional Overturning Circulation (AMOC), OHC., and dynamic sea level (DSL), are all reasonably reproduced.

Datasets for the CMIP6 Scenario Model Intercomparison Project (ScenarioMIP) Simulations with the Coupled Model CAS FGOALS-f3-L - Shuwen Zhao; Yongqiang Yu; Pengfei Lin; Hailong Liu; Bian He; Qing Bao; Yuyang Guo; Lijuan Hua; Kangjun Chen; Xiaowei Wang (Advances in Atmospheric Sciences, 2021)
The datasets for the tier-1 Scenario Model Intercomparison Project (ScenarioMIP) experiments from the Chinese Academy of Sciences (CAS) Flexible Global Ocean-Atmosphere-Land System model, finite-volume version 3 (CAS FGOALS-f3-L) are described in this study. ScenarioMIP is one of the core MIP experiments in phase 6 of the Coupled Model Intercomparison Project (CMIP6). Considering future CO 2 , CH 4 , N 2 O and other gases’ concentrations, as well as land use, the design of ScenarioMIP involves eight pathways, including two tiers (tier-1 and tier-2) of priority. Tier-1 includes four combined Shared Socioeconomic Pathways (SSPs) with radiative forcing, i.e., SSP1-2.6, SSP2-4.5, SSP3-7.0 and SSP5-8.5, in which the globally averaged radiative forcing at the top of the atmosphere around the year 2100 is approximately 2.6, 4.5, 7.0 and 8.5 W m −2 , respectively. This study provides an introduction to the ScenarioMIP datasets of this model, such as their storage location, sizes, variables, etc. Preliminary analysis indicates that surface air temperatures will increase by about 1.89°C, 3.07°C, 4.06°C and 5.17°C by around 2100 under these four scenarios, respectively. Meanwhile, some other key climate variables, such as sea-ice extension, precipitation, heat content, and sea level rise, also show significant long-term trends associated with the radiative forcing increases. These datasets will help us understand how the climate will change under different anthropogenic and radiative forcings.

CAS-ESM2.0 Model Datasets for the CMIP6 Ocean Model Intercomparison Project Phase 1 (OMIP1) - Xiao Dong; Jiangbo Jin; Hailong Liu; He Zhang; Minghua Zhang; Pengfei Lin; Qingcun Zeng; Guangqing Zhou; Yongqiang Yu; Mirong Song; Zhaohui Lin; Ruxu Lian; et al. (Advances in Atmospheric Sciences, 2021)
As a member of the Chinese modeling groups, the coupled ocean-ice component of the Chinese Academy of Sciences’ Earth System Model, version 2.0 (CAS-ESM2.0), is taking part in the Ocean Model Intercomparison Project Phase 1 (OMIP1) experiment of phase 6 of the Coupled Model Intercomparison Project (CMIP6). The simulation was conducted, and monthly outputs have been published on the ESGF (Earth System Grid Federation) data server. In this paper, the experimental dataset is introduced, and the preliminary performances of the ocean model in simulating the global ocean temperature, salinity, sea surface temperature, sea surface salinity, sea surface height, sea ice, and Atlantic Meridional Overturning Circulation (AMOC) are evaluated. The results show that the model is at quasi-equilibrium during the integration of 372 years, and performances of the model are reasonable compared with observations. This dataset is ready to be downloaded and used by the community in related research, e.g., multi-ocean-sea-ice model performance evaluation and interannual variation in oceans driven by prescribed atmospheric forcing.

Highly enriched N‐containing organic molecules of Synechococcus lysates and their rapid transformation by heterotrophic bacteria - Qiang Zheng; Wenxin Lin; Yu Wang; Yunyun Li; Chen He; Yuan Shen; Weidong Guo; Quan Shi; Nianzhi Jiao (Limnology and Oceanography, 2021)
Phytoplankton are major contributors of labile dissolved organic matter to marine euphotic zone ecosystems. Viral‐mediated phytoplankton lysis releases a considerable amount of bioavailable cellular contents and facilitates localized heterotrophic bacterial growth. The rapid turnover times of this labile organic matter renders it difficult to trace their transformation within natural environments. In the present study, we used a model phototroph‐heterotroph coculture system to investigate the organic molecular variation during cyanophage‐induced Synechococcus lysis and post‐lysis periods using fluorescence spectroscopy and ultrahigh resolution mass spectrometry analyses. Approximately 80% of the Synechococcus lysates were respired to carbon dioxide within 2 days coupled to rapid regeneration of inorganic nutrients. Five fluorescent dissolved organic matter components were detected in the incubations including four humic‐like and one protein‐like components, and their abundances varied markedly with the succession of the viral lysis process. Viral lysis promoted the transformation of Synechococcus biomass to dissolved organic matter, and heterotrophic bacterial metabolism facilitated the transformation of organic molecules from relatively high (avg. ~ 430 Da) to low (avg. ~ 360 Da) molecular weight, corresponding to variation in their bioavailability. The Synechococcus ‐derived organic matter was highly enriched in N‐containing organic molecules. Identified metabolites within the cultures primarily comprised amino acids or oligopeptides and other low‐molecular‐weight organic acids, carbohydrates, nucleotides, lipids, biogenic amines, and porphyrins. Among these, oligopeptides, nucleotides, and lipid compounds significantly increased with viral lysis. These results provide insight into biogeochemical cycling mediated by viral shunts in oceans, thus deepening our understanding of microbial food webs at the molecular level.

Sun glint correction with an inherent optical properties data processing system - Jun Chen; Xianqiang He; Zhongli Liu; Nan Lin; Qianguo Xing; Delu Pan (International Journal of Remote Sensing, 2021)

Preliminary study on relationships among nutritional risk, serum prealbumin, and peripheral blood T cell subsets in patients with severe COVID-19 - Yanli Li; Yanbo Sun; Jing He; Peng Zhao; Pengju Luo; Jinsong Bai; Weiming Li; Shumin Li; Yueying Lin; Yunyun Cen (Infectious Diseases, 2021)

Simulating warmer and drier climate increases root production but decreases root decomposition in an alpine grassland on the Tibetan plateau - Huiying Liu; Li Lin; Hao Wang; Zhenhua Zhang; Zijian Shangguan; Xiaojuan Feng; Jin-Sheng He (Plant and Soil, 2021)

Identification of 5S and 45S rDNA sites in Chrysanthemum species by using oligonucleotide fluorescence in situ hybridization (Oligo-FISH) - Jun He; Sisi Lin; Zhongyu Yu; Aiping Song; Zhiyong Guan; Weimin Fang; Sumei Chen; Fei Zhang; Jiafu Jiang; Fadi Chen; Haibin Wang (Molecular Biology Reports, 2021)

Lung injury induced by pyrrolizidine alkaloids depends on metabolism by hepatic cytochrome P450s and blood transport of reactive metabolites - Yisheng He; Wei Lian; Liang Ding; Xiaoyu Fan; Jiang Ma; Qing-Yu Zhang; Xinxin Ding; Ge Lin (Archives of Toxicology, 2021)

Hydrothermal dolomitization in the Middle Permian in the Central Sichuan Basin, SW China: evidence from petrology, geochemistry, and fluid inclusions - Lin Qi; Yifan Gu; Puwei He; Zhanlei Wang; Yuqiang Jiang; Shun Li; Yadong Zhou (Arabian Journal of Geosciences, 2021)

Isolation and characterization of two new chroman-4-ones from the endophytic fungus Penicillium chrysogenum obtained from Eucommia ulmoides Oliver - Sheng-Yue Liu; Li-Zhi Wang; Yue-Fei Wang; Lin Li; Guo-Ying Han; Bing-Yang Zhang; Ying Guo; Yong-Zhi He; Shi-Ming Fang; Han Zhang (Natural Product Research, 2020)

Quantitative Determination of Glymphatic Flow Using Spectrophotofluorometry - Yu Zhang; Jian Song; Xu-Zhong He; Jian Xiong; Rong Xue; Jia-Hao Ge; Shi-Yu Lu; Die Hu; Guo-Xing Zhang; Guang-Yin Xu; Lin-Hui Wang (Neuroscience Bulletin, 2020)

Weathering the storm: COVID-19 infection in patients with hematological malignancies - Lin-qin Wang; Elaine Tan Su Yin; Guo-qing Wei; Yong-xian Hu; Arnon Nagler; He Huang (Journal of Zhejiang University-SCIENCE B, 2020)

Initiation mechanism of the Baige landslide on the upper reaches of the Jinsha River, China - Shi-lin Zhang; Yue-ping Yin; Xie-wen Hu; Wen-pei Wang; Sai-nan Zhu; Nan Zhang; Shui-he Cao (Landslides, 2020)

Unraveling neuroHIV in the Presence of Substance Use Disorders - Yu Lin; Johnny J. He; Roger Sorensen; Linda Chang (Journal of Neuroimmune Pharmacology, 2020)

Valine acts as a nutritional signal in brain to activate TORC1 and attenuate postprandial ammonia-N excretion in Chinese perch (Siniperca chuatsi) - Jie Wang; Xu-Fang Liang; Shan He; Yan-Peng Zhang; Jiao Li; Kang Huang; Lin-Jie Shi; Ping Ren (Fish Physiology and Biochemistry, 2020)

Effects of MC-LR on histological structure and cell apoptosis in the kidney of grass carp (Ctenopharyngodon idella) - Li He; Lin Liu; Changgao Lin; Jiming Ruan; Ximei Liang; Ying Zhou; Lili Wei (Fish Physiology and Biochemistry, 2020)

Identification of progranulin as a novel diagnostic biomarker for early-onset sepsis in neonates - Kai-Di Yang; Yu He; Sa Xiao; Qing Ai; Jia-Lin Yu (European Journal of Clinical Microbiology & Infectious Diseases, 2020)

Association of in-hospital intensive statins dosage and death in arteriosclerotic cardiovascular disease with percutaneous coronary intervention: insights of multicentre cohort from China - Peng-yuan Chen; Yuan-hui Liu; Chong-yang Duan; Hua-lin Fan; Li-huan Zeng; Wei Guo; Lei Jiang; Xue-biao Wei; Wen-fei He; Sha Tao; Zhi-qiang Guo; Ji-yan Chen; et al. (European Journal of Clinical Pharmacology, 2020)

An allotriploid hybrid developed from a female 2n gamete was obtained from Eriobotrya japonica (Thunb.) Lindl × E. deflexa (Hemsl.) Nakai - Yanjuan Song; Jiangbo Dang; Weiwei Chen; Guo Wen; Qiao He; Xiaolin Li; Shoukai Lin; Guolu Liang; Qigao Guo (Euphytica, 2020)

Greater promotion of DNRA rates and nrfA gene transcriptional activity by straw incorporation in alkaline than in acidic paddy soils - Ren Bai; Yun-Ting Fang; Liu-Ying Mo; Ju-Pei Shen; Lin-Lin Song; Ya-Qi Wang; Li-Mei Zhang; Ji-Zheng He (Soil Ecology Letters, 2020)

Stability analysis of open-pit gold mine slopes and optimization of mining scheme in Inner Mongolia, China - Shu-lin Ren; Zhi-gang Tao; Man-chao He; Shi-hui Pang; Meng-nan Li; Hao-tian Xu (Journal of Mountain Science, 2020)

Exploring the potential of deep factorization machine and various gradient boosting models in modeling daily reference evapotranspiration in China - Zhigao Zhou; Lin Zhao; Aiwen Lin; Wenmin Qin; Yunbo Lu; Jingyi Li; Yang Zhong; Lijie He (Arabian Journal of Geosciences, 2020)

Endoplasmic reticulum‐associated degradation mediated by MoHrd1 and MoDer1 is pivotal for appressorium development and pathogenicity of Magnaporthe oryzae - Wei Tang; Haolang Jiang; Osakina Aron; Min Wang; Xueyu Wang; Jiangfeng Chen; Birong Lin; Xuehang Chen; Qiaojia Zheng; Xiuqin Gao; Dou He; Airong Wang; et al. (Environmental Microbiology, 2020)
Summary Most secretory proteins are folded and modified in the endoplasmic reticulum (ER); however, protein folding is error‐prone, resulting in toxic protein aggregation and cause ER stress. Irreversibly misfolded proteins are subjected to ER‐associated degradation (ERAD), modified by ubiquitination, and degraded by the 26S proteasome. The yeast ERAD ubiquitin ligase Hrd1p and multispanning membrane protein Der1p are involved in ubiquitination and transportation of the folding‐defective proteins. Here, we performed functional characterization of MoHrd1 and MoDer1 and revealed that both of them are localized to the ER and are pivotal for ERAD substrate degradation and the ER stress response. MoHrd1 and MoDer1 are involved in hyphal growth, asexual reproduction, infection‐related morphogenesis, protein secretion and pathogenicity of M. oryzae . Importantly, MoHrd1 and MoDer1 mediated conidial autophagic cell death and subsequent septin ring assembly at the appressorium pore, leading to abnormal appressorium development and loss of pathogenicity. In addition, deletion of MoHrd1 and MoDer1 activated the basal unfolded protein response (UPR) and autophagy, suggesting that crosstalk between ERAD and two other closely related mechanisms in ER quality control system (UPR and autophagy) governs the ER stress response. Our study indicates the importance of ERAD function in fungal development and pathogenesis of M. oryzae .

Effects of Plant Diversity and Plant Density on Ecosystem Functions in Floating Constructed Wetlands - Wenjuan Han; Xiaoling Sheng; Jiongni Shao; Jia Jiang; Qinru He; Ying Lin (Water, Air, & Soil Pollution, 2020)

Activation of p62-Keap1-Nrf2 Pathway Protects 6-Hydroxydopamine-Induced Ferroptosis in Dopaminergic Cells - Yiran Sun; Libo He; Taoyu Wang; Wan Hua; Huan Qin; Jingjin Wang; Li Wang; Wanqin Gu; Tingting Li; Na Li; Xinanbei Liu; Fang Chen; et al. (Molecular Neurobiology, 2020)

Quantitative Assessment of Hippocampal Tau Pathology in AD and PART - Lei Zhang; Yankai Jiang; Jie Zhu; Huazheng Liang; Xiangyang He; Jiahong Qian; Hai Lin; Yubo Tao; Keqing Zhu (Journal of Molecular Neuroscience, 2020)
To quantitatively assess the distribution pattern of hippocampal tau pathology in Alzheimer’s disease (AD) and primary age-related tauopathy (PART), we investigated the distribution of phosphorylated tau protein (AT8) in 6 anatomically defined subregions of the hippocampal formation and developed a mathematical algorithm to compare the patterns of tau deposition in PART and AD. We demonstrated regional patterns of selective vulnerability as distinguishing features of PART and AD in functionally relevant structures of the hippocampus. In AD cases, tau pathology was high in both CA1 and subiculum, followed by CA2/3, entorhinal cortex (EC), CA4, and dentate gyrus (DG). In PART, the severity of tau pathology in CA1 and subiculum was high, followed by EC, CA2/3, CA4, and DG. There are significant differences between sector DG and CA1, DG and subiculum in both AD and PART.

Liver Function of Male Rats Exposed to Manganese at Different Time Points - Xiaonian Zhu; Lin Yang; Yonghua He; Yi Sun; Wenxiang Shi; Chaoyan Ou (Biological Trace Element Research, 2020)

Cerebral Organoids Repair Ischemic Stroke Brain Injury - Shu-Na Wang; Zhi Wang; Tian-Ying Xu; Ming-He Cheng; Wen-Lin Li; Chao-Yu Miao (Translational Stroke Research, 2020)
Stroke is the second leading cause of death and main cause of disability worldwide, but with few effective therapies. Although stem cell-based therapy has been proposed as an exciting regenerative medicine strategy for brain injury, there are limitations. The developed cerebral organoids (COs) represent a promising transplantation source for stroke that remains to be answered. Here, we transplanted COs at 55 days and explored the feasibility in the rat middle cerebral artery occlusion (MCAO) model of stroke. COs transplantation at 6 h or even 24 h after MCAO significantly reduces brain infarct volume and improves neurological motor function. Transplanted COs show the potential of multilineage differentiation to mimic in vivo cortical development, support motor cortex region-specific reconstruction, form neurotransmitter-related neurons, and achieve synaptic connection with host brain via in situ differentiation and cell replacement in stroke. Cells from transplanted COs show extensive migration into different brain regions along corpus callosum. The mechanisms underlying COs transplantation therapy are also associated with enhanced neurogenesis, synaptic reconstruction, axonal regeneration and angiogenesis, and decreased neural apoptosis with more survival neurons after stroke. Moreover, COs transplantation promotes predominantly exogenous neurogenesis in the transplantation periphery of ipsilateral cortex and predominantly endogenous neurogenesis in the hippocampus and subventricular zone. Together, we demonstrate the efficacy and underlying mechanisms of COs transplantation in stroke. This preliminary but promising study provides first-hand preclinical evidence for COs transplantation as a potential and effective intervention for stroke treatment.

ClPLD5, a phospholipase gene is involved in protection of cytoskeleton stability in pollen of self-imcompatible ‘Xiangshui’ lemon (Citrus limon) - Wei Lin; Minhphu Do; Mi Wei; Xinhua He; Yuan Liu; Zhiyi Fan; Shuwei Zhang; Cong Luo; Guixiang Huang; Guibing Hu (Plant Cell, Tissue and Organ Culture (PCTOC), 2020)

Transient receptor potential ankyrin 1 contributes to the ATP-elicited oxidative stress and inflammation in THP-1-derived macrophage - Chao Tian; Xiaobo Han; Lang He; Feng Tang; Rongqi Huang; Zuoxian Lin; Shuai Li; Sihao Deng; Junjie Xu; Hualin Huang; Huifang Zhao; Zhiyuan Li (Molecular and Cellular Biochemistry, 2020)

Experimental Study on Ultra-low Friction Effect of Granite Block Under Coupled Static and Dynamic Loads - Dongqiao Liu; Youwen Lin; Yang Wang; Manchao He; Shudong Zhang (Geotechnical and Geological Engineering, 2020)

Preparation and uranium (VI) biosorption for tri-amidoxime modified marine fungus material - Jingwen Han; Lin Hu; Leqing He; Kang Ji; Yaqing Liu; Can Chen; Xiaomei Luo; Ni Tan (Environmental Science and Pollution Research, 2020)

Selenium Deficiency in Chickens Induces Intestinal Mucosal Injury by Affecting the Mucosa Morphology, SIgA Secretion, and GSH-Px Activity - Xianjing He; Yucai Lin; Shuai Lian; Dongbo Sun; Donghua Guo; Jianfa Wang; Rui Wu (Biological Trace Element Research, 2020)

Simulation and Improvements of Oceanic Circulation and Sea Ice by the Coupled Climate System Model FGOALS-f3-L - Yuyang Guo; Yongqiang Yu; Pengfei Lin; Hailong Liu; Bian He; Qing Bao; Bo An; Shuwen Zhao; Lijuan Hua (Advances in Atmospheric Sciences, 2020)

CAS-FGOALS Datasets for the Two Interglacial Epochs of the Holocene and the Last Interglacial in PMIP4 - Weipeng Zheng; Yongqiang Yu; Yihua Luan; Shuwen Zhao; Bian He; Li Dong; Mirong Song; Pengfei Lin; Hailong Liu (Advances in Atmospheric Sciences, 2020)
Two versions of the Chinese Academy of Sciences Flexible Global Ocean-Atmosphere-Land System model (CAS-FGOALS), version f3-L and g3, are used to simulate the two interglacial epochs of the mid-Holocene and the Last Interglacial in phase 4 of the Paleoclimate Modelling Intercomparison Project (PMIP4), which aims to study the impact of changes in orbital parameters on the Earth’s climate. Following the PMIP4 experimental protocols, four simulations for the mid-Holocene and two simulations for the Last Interglacial have been completed, and all the data, including monthly and daily outputs for the atmospheric, oceanic, land and sea-ice components, have been released on the Earth System Grid Federation (ESGF) node. These datasets contribute to PMIP4 and CMIP6 (phase 6 of the Coupled Model Intercomparison Project) by providing the variables necessary for the two interglacial periods. In this paper, the basic information of the CAS-FGOALS models and the protocols for the two interglacials are briefly described, and the datasets are validated using proxy records. Results suggest that the CAS-FGOALS models capture the large-scale changes in the climate system in response to changes in solar insolation during the interglacial epochs, including warming in mid-to-high latitudes, changes in the hydrological cycle, the seasonal variation in the extent of sea ice, and the damping of interannual variabilities in the tropical Pacific. Meanwhile, disagreements within and between the models and the proxy data are also presented. These datasets will help the modeling and the proxy data communities with a better understanding of model performance and biases in paleoclimate simulations.

Overview of the CMIP6 Historical Experiment Datasets with the Climate System Model CAS FGOALS-f3-L - Yuyang Guo; Yongqiang Yu; Pengfei Lin; Hailong Liu; Bian He; Qing Bao; Shuwen Zhao; Xiaowei Wang (Advances in Atmospheric Sciences, 2020)
The three-member historical simulations by the Chinese Academy of Sciences Flexible Global Ocean-Atmosphere-Land System model, version f3-L (CAS FGOALS-f3-L), which is contributing to phase 6 of the Coupled Model Intercomparison Project (CMIP6), are described in this study. The details of the CAS FGOALS-f3-L model, experiment settings and output datasets are briefly introduced. The datasets include monthly and daily outputs from the atmospheric, oceanic, land and sea-ice component models of CAS FGOALS-f3-L, and all these data have been published online in the Earth System Grid Federation (ESGF, https://esgf-node.llnl.gov/projects/cmip6/ ). The three ensembles are initialized from the 600th, 650th and 700th model year of the preindustrial experiment (piControl) and forced by the same historical forcing provided by CMIP6 from 1850 to 2014. The performance of the coupled model is validated in comparison with some recent observed atmospheric and oceanic datasets. It is shown that CAS FGOALS-f3-L is able to reproduce the main features of the modern climate, including the climatology of air surface temperature and precipitation, the long-term changes in global mean surface air temperature, ocean heat content and sea surface steric height, and the horizontal and vertical distribution of temperature in the ocean and atmosphere. Meanwhile, like other state-of-the-art coupled GCMs, there are still some obvious biases in the historical simulations, which are also illustrated. This paper can help users to better understand the advantages and biases of the model and the datasets.

Genesis of the Maoping carbonate-hosted Pb–Zn deposit, northeastern Yunnan Province, China: evidences from geology and C–O–S–Pb isotopes - Yufan He; Tao Wu; Zhilong Huang; Lin Ye; Ping Deng; Zhenzhong Xiang (Acta Geochimica, 2020)

Impact of Maternal Separation on Dopamine System and its Association with Parkinson's Disease - Kai-jie He; Yu-ting Zhang; Shi-zhuang Wei; Shu-min Jiang; Lin Xu; Chao Ren; Fen Wang (NeuroMolecular Medicine, 2020)

Silencing of LRP1 Exacerbates Inflammatory Response Via TLR4/NF-κB/MAPKs Signaling Pathways in APP/PS1 Transgenic Mice - Yingying He; John Bosco Ruganzu; Quzhao Zheng; Xiangyuan Wu; Hui Jin; Xiaoqian Peng; Bo Ding; Chengheng Lin; Shengfeng Ji; Yanbing Ma; Weina Yang (Molecular Neurobiology, 2020)

RGFP966 inactivation of the YAP pathway attenuates cardiac dysfunction induced by prolonged hypothermic preservation - Xiao-he Zheng; Lin-lin Wang; Ming-zhi Zheng; Jin-jie Zhong; Ying-ying Chen; Yue-liang Shen (Journal of Zhejiang University-SCIENCE B, 2020)

Gene UCHL1 expresses specifically in mouse uterine decidual cells in response to estrogen - Lishuang Hao; Di Song; Mengfei Zhuang; Yan Shi; Lin Yu; Yaping He; Jian Wang; Tingting Zhang; Zhaogui Sun (Histochemistry and Cell Biology, 2020)

Generation of a porcine reproductive and respiratory syndrome virus expressing a marker gene inserted between ORF4 and ORF5a - Yuxu Wang; Wei He; Qingqing Li; Xin Xie; Nian Qin; Hao Wang; Jiabin Huang; Siyuan Lin; Kang Ouyang; Ying Chen; Weijian Huang; Zuzhang Wei (Archives of Virology, 2020)

Early evidence of trepanation along the Yellow River Basin in Neolithic China - Yawei Zhou; Shuang Lin; Wanfa Gu; Letian He; Qun Zhang; Hui-Yuan Yeh (Archaeological and Anthropological Sciences, 2020)
Trepanation is a long-lasting ancient practice found around the world with diverse motivations. However, the distribution and motivation of intentional trepanation in China remain unclear. This study presents one of the earliest trepanations on a male adult individual who is unearthed from the Shuanghuaishu site in Gongyi, Henan, dating back to the late Yangshao cultural period (3500–2900 BC). The macroscopic and microscopic observation, alongside with micro-CT scan, are conducted to further evaluate the conditions on the edges of the perforation and intracranial situation. The oval perforation is located on the occipital bone, and neither fracture nor apparent healing signs are observed on the margins. Archeological evidences and simulated experiment indicate that the trepanation could be conducted by drilling the tables of the skull with a V-bladed stone tool. In view of the location of the perforation and the limited details on the edges, the motivation behind the trepanation could be due to the medical treatment of trauma on the occipital bone or a postmortem ritual. The analysis of the early trepanation along the Yellow River Basin provides further evidence on the ancient human behavior and enriches our understanding of the origin and distribution of trepanation in Neolithic China.

Experimental investigation for dynamic instability of coal-rock masses in horizontal section mining of steeply inclined coal seams - Zheng-yi Wang; Lin-ming Dou; Jiang He; An-ye Cao; Xiong-wei Li; Peng-bo Li; Chang-sheng Wu (Arabian Journal of Geosciences, 2020)

Ancestral niche separation and evolutionary rate differentiation between sister marine flavobacteria lineages - Chun‐Xu Xue; Hao Zhang; He‐Yu Lin; Ying Sun; Danli Luo; Yongjie Huang; Xiao‐Hua Zhang; Haiwei Luo (Environmental Microbiology, 2020)
Summary Marine flavobacteria are specialists for polysaccharide degradation. They dominate in habitats enriched with polysaccharides, but are also prevalent in pelagic environments where polysaccharides are less available. These niches are likely occupied by distinct lineages, but evolutionary processes underlying their niche differentiation remain elusive. Here, genomic analyses and physiological assays indicate that the sister flavobacteria lineages Leeuwenhoekiella and Nonlabens likely explore polysaccharide‐rich macroalgae and polysaccharide‐poor pelagic niches respectively. Phylogenomic analyses inferred that the niche separation likely occurred anciently and coincided with increased sequence evolutionary rate in Nonlabens compared with Leeuwenhoekiella . Further analyses ruled out the known mechanisms likely driving evolutionary rate acceleration, including reduced selection efficiency, decreased generation time and increased mutation rate. In particular, the mutation rates were determined using an unbiased experimental method, which measures the present‐day populations and may not reflect ancestral populations. These data collectively lead to a new hypothesis that an ancestral and transient mutation rate increase resulted in evolutionary rate increase in Nonlabens . This hypothesis was supported by inferring that gains and losses of genes involved in SOS response, a mechanism known to drive transiently increased mutation rate, coincided with evolutionary rate acceleration. Our analyses highlight the evolutionary mechanisms underlying niche differentiation of flavobacteria lineages.

The undrained vertical and horizontal bearing capacity of internal skirted foundation in clay - Chong Jiang; Liu Lin; Chen Li; Tian-Bin Li; Jiali He (European Journal of Environmental and Civil Engineering, 2020)

Anomalous distribution of distinctive water masses over the Carlsberg Ridge in May 2012 - Hailun He; Yuan Wang; Xiqiu Han; Yanzhou Wei; Pengfei Lin; Zhongyan Qiu; Yejian Wang (Ocean Science, 2020)
In May 2012, we conducted a hydrographic survey over the Carlsberg Ridge in the northwest Indian Ocean. In this paper, we use these station data, in combination with some free-floating Argo profiles, to obtain the sectional temperature and salinity fields, and subsequently, the hydrographic characteristics are comprehensively analyzed. Through the basic T–S diagram, three salty water masses, Arabian Sea High-Salinity Water, Persian Gulf Water, and Red Sea Water, are identified. The sectional data show a clear ventilation structure associated with Arabian Sea High-Salinity Water. The 35.8 psu salty water sinks at 6.9∘ N and extends southward to 4.4∘ N at depths around the thermocline, where the thermocline depth is in the range of 100 to 150 m. This salty thermocline extends much further south than climatology indicates. Furthermore, the temperature and salinity data are used to compute the absolute geostrophic current over the specific section, and the results show mesoscale eddy vertical structure different from some widely used oceanic reanalysis data. We also find a west-propagating planetary wave at 6∘ N, and the related features are described in terms of phase speed and horizontal and vertical structures.

A new epicatechin glucopyranoside derivative from Styrax suberifolius - Bing-Lei Liu; Xin Hu; Hua-Liang He; Lin Qiu; You-Zhi Li; Wen-Bing Ding (Natural Product Research, 2020)

Pholiotone A, a new polyketide derivative from Pholiota sp - Yingchao He; Renlei Wang; Bin Huang; Qun Dai; Jie Lin (Natural Product Research, 2020)

Drug vector representation: a tool for drug similarity analysis - Liping Lin; Luoyao Wan; Huaqin He; Wei Liu (Molecular Genetics and Genomics, 2020)

Rediscovery of the abyssal species Peniagone leander Pawson and Foell, 1986 (Holothuroidea: Elasipodida: Elpidiidae): the first record from the Mariana Trench area - Lin Gong; Xinzheng Li; Ning Xiao; Lisheng He; Haibin Zhang; Yong Wang (Journal of Oceanology and Limnology, 2020)

Dynamic response and mechanical deformation properties of the soil cutting slope under train cyclic loads - Qiang Xie; Zhi-hui Wu; Chun-bo He; Jie Dong; Zhi-lin Cao; Li Liang (Arabian Journal of Geosciences, 2020)

GPI7‐mediated glycosylphosphatidylinositol anchoring regulates appressorial penetration and immune evasion during infection of Magnaporthe oryzae - Caiyun Liu; Junjie Xing; Xuan Cai; Ahmed Hendy; Wenhui He; Jun Yang; Junbing Huang; You‐Liang Peng; Lauren Ryder; Xiao‐Lin Chen (Environmental Microbiology, 2020)
Summary Glycosylphosphatidylinositol (GPI) anchoring plays key roles in many biological processes by targeting proteins to the cell wall; however, its roles are largely unknown in plant pathogenic fungi. Here, we reveal the roles of the GPI anchoring in Magnaporthe oryzae during plant infection. The GPI‐anchored proteins were found to highly accumulate in appressoria and invasive hyphae. Disruption of GPI7 , a GPI anchor‐pathway gene, led to a significant reduction in virulence. The Δ gpi7 mutant showed significant defects in penetration and invasive growth. This mutant also displayed defects of the cell wall architecture, suggesting GPI7 is required for cell wall biogenesis. Removal of GPI‐anchored proteins in the wild‐type strain by hydrofluoric acid (HF) pyridine treatment exposed both the chitin and β‐1,3‐glucans to the host immune system. Exposure of the chitin and β‐1,3‐glucans was also observed in the Δ gpi7 mutant, indicating GPI‐anchored proteins are required for immune evasion. The GPI anchoring can regulate subcellular localization of the Gel proteins in the cell wall for appressorial penetration and abundance of which for invasive growth. Our results indicate the GPI anchoring facilitates the penetration of M. oryzae into host cells by affecting the cell wall integrity and the evasion of host immune recognition.

Trends in downward surface shortwave radiation from multi‐source data over China during 1984–2015 - Zhigao Zhou; Aiwen Lin; Lunche Wang; Wenmin Qin; Yang zhong; Lijie He (International Journal of Climatology, 2020)
The clear knowledge of decadal variability of surface solar radiation (SSR) is of vitally significant for understanding hydrological and biological processes and climate prediction. However, existing studies have shown observed SSR over China may have large discrepancies and inhomogeneity in decadal variability due to sensitivity drift, inaccurate calibrations and instrument replacement. Therefore, a new procedure of station selection was proposed to eliminate errors and to derive “true” SSR values in this study. Afterward, two satellite retrieves of SSR, including Clouds and the Earth's Radiant Energy System‐energy balanced and filled product (CERES‐EBAF) (edition 4) and Global Energy and Water Cycle Experiment‐Surface Radiation Budget (GEWEX‐SRB) (Version 3.0), and three reanalysis products, including National Centers for Environmental Prediction‐National Center for Atmospheric Research (NCEP‐NCAR), national centers for environmental prediction‐/department of energy (NCEP‐DOE) and Modern‐Era Retrospective analysis for Research and Applications, version 2 (MERRA‐2) were evaluated using “true” SSR values at 39 homogeneous stations from the China Meteorological Administration and it was found that although all five products overestimated SSR, two satellite retrieves showed better accuracy with an overall R of 0.95, an root mean squared error (RMSE) of 20.4 W m −2 and mean absolute bias error (MAE) of 14.9 W m −2 for CERES‐EBAF and an overall R of 0.92, an RMSE of 27.7 W m −2 and MAE of 21.2 W m −2 for GEWEX‐SRB across China. Meanwhile, inter‐comparisons between trends of observations and trends of two satellite retrieves in this study showed that the new trends derived from two satellite retrieves (+0.78 W m −2 decade −1 ) were good agreement with trends of observation (+0.92 W m −2 decade −1 ) from 1994 to 2015. However, trends of SSR (+5.8 W m −2 decade −1 ) in situ measurements were still in disagreement with the trends of SSR (−3.7 W m −2 decade −1 ) derived from two satellite retrieves from 1984 to 1993 because of the sensitivity drift and instrument replacement in this period. The possible reasons for decadal variability of SSR in China were detected and it was found that variations in aerosol optical depth (AOD) and aerosol‐cloud interaction, rather than cloud, were suggested to be likely the main influencing factor of decadal variability of SSR across China from 1984 to 2015.

Long interpregnancy interval and adverse perinatal outcomes: A retrospective cohort study - Jing Lin; Han Liu; Dan-Dan Wu; Hong-Tao Hu; Hui-Hui Wang; Cheng-Liang Zhou; Xin-Mei Liu; Xiao-Jun Chen; Jian-Zhong Sheng; He-Feng Huang (Science China Life Sciences, 2020)

The defective effect of starch branching enzyme IIb from weak to strong induces the formation of biphasic starch granules in amylose-extender maize endosperm - Wei He; Xiangguo Liu; Lingshang Lin; Ahui Xu; Dongyun Hao; Cunxu Wei (Plant Molecular Biology, 2020)

Reversal of Social Recognition Deficit in Adult Mice with MECP2 Duplication via Normalization of MeCP2 in the Medial Prefrontal Cortex - Bin Yu; Bo Yuan; Jian-Kun Dai; Tian-lin Cheng; Sheng-Nan Xia; Ling-Jie He; Yi-Ting Yuan; Yue-Fang Zhang; Hua-Tai Xu; Fu-Qiang Xu; Zhi-Feng Liang; Zi-Long Qiu (Neuroscience Bulletin, 2020)

Faba Bean Organs Differed in Their Effects on Maize Seed Germination Rate and Soil Microbial Activities as well as Their Decomposition Patterns in a Regosol Soil - Zhibin He; Luhua Yao; Xuefeng Zhang; Yang Li; Dengke Wang; Lin Kang; Cui Cui; Aiying Huang; Ruiji Yang; Qianlin Xiao; Yanjun Guo (Journal of Soil Science and Plant Nutrition, 2020)

Depositional sequences and microfacies of Lower Carboniferous strata in the Marsel block of the Chu-Sarysu Basin, Southern Kazakhstan - Yuan Wang; Changsong Lin; Yanda Sun; Jingyan Liu; Hao Li; Haiquan He; Qinglong Wang; Muye Ji; Manli Zhang; Bozhi Zhao; Zhiyuan Zhang (Carbonates and Evaporites, 2020)

Influence of Aphis gossypii feeding on defense strategy of native and introduced populations of Ageratina adenophora - Ying Lin; Shu-Qi He; Zhi-Hui Lu; Yu-Lin Gao; Yan-Ru Duan; Zheng-Yue Li; Bin Chen; Fu-Rong Gui (Arthropod-Plant Interactions, 2020)

Identification of a novel bocaparvovirus in a wild squirrel in Kunming, Yunnan Province, China - Jiali Wang; Nan Li; Zhao Li; Lin Liu; Yuwen He; Jinxin Meng; Shunxiang Li; Jinglin Wang (Archives of Virology, 2020)

Plastic pollution in croplands threatens long‐term food security - Dan Zhang; Ee Ling Ng; Wanli Hu; Hongyuan Wang; Pablo Galaviz; Hude Yang; Wentao Sun; Chongxiao Li; Xingwang Ma; Bin Fu; Peiyi Zhao; Fulin Zhang; et al. (Global Change Biology, 2020)
Plastic pollution is a global concern given its prevalence in aquatic and terrestrial ecosystems. Studies have been conducted on the distribution and impact of plastic pollution in marine ecosystems, but little is known on terrestrial ecosystems. Plastic mulch has been widely used to increase crop yields worldwide, yet the impact of plastic residues in cropland soils to soil health and crop production in the long term remained unclear. In this paper, using a global meta‐analysis, we found that the use of plastic mulch can indeed increase crop yields on average by 25%–42% in the immediate season due to the increase of soil temperature (+8%) and moisture (+17%). However, the unabated accumulation of film residues in the field negatively impacts its physicochemical properties linked to healthy soil and threatens food production in the long term. It has multiple negative impacts on plant growth including crop yield (at the mean rate of −3% for every additional 100 kg/ha of film residue), plant height (−2%) and root weight (−5%), and soil properties including soil water evaporation capacity (−2%), soil water infiltration rate (−8%), soil organic matter (−0.8%) and soil available phosphorus (−5%) based on meta‐regression. Using a nationwide field survey of China, the largest user of plastic mulch worldwide, we found that plastic residue accumulation in cropland soils has reached 550,800 tonnes, with an estimated 6%–10% reduction in cotton yield in some polluted sites based on current level of plastic residue content. Immediate actions should be taken to ensure the recovery of plastic film mulch and limit further increase in film residue loading to maintain the sustainability of these croplands.

Variation in Water Masses on Shelf of Northern Bering Sea in September 2016-2018 - Yingjie Wang; Na Liu; Lina Lin; Yan He; Bin Kong; Zhanhai Zhang (Marine Geodesy, 2020)

Detection of serum IgM and IgG for COVID-19 diagnosis - Ling Zhong; Junlan Chuan; Bo Gong; Ping Shuai; Yu Zhou; Yi Zhang; Zhilin Jiang; Dingding Zhang; Xiaoqi Liu; Shi Ma; Yi Huang; He Lin; et al. (Science China Life Sciences, 2020)

MiR-145 alleviates Hcy-induced VSMC proliferation, migration, and phenotypic switch through repression of the PI3K/Akt/mTOR pathway - Minghao Zhang; Fan Li; Xiuyu Wang; Jian Gong; Yushan Xian; Guan Wang; Zihan Zheng; Chenxu Shang; Bo Wang; Yanhao He; Weirong Wang; Rong Lin (Histochemistry and Cell Biology, 2020)

Microwave-Assisted Modification of Corncob with Trimethylammonium Chloride for Efficient Removal of Cr(VI): Preparation, Characterization, and Mechanism - Yinhai He; Shaoke Han; Hai Lin; Yingbo Dong (Water, Air, & Soil Pollution, 2020)

Immunogenicity noninferiority study of 2 doses and 3 doses of an Escherichia coli-produced HPV bivalent vaccine in girls vs. 3 doses in young women - Yue-Mei Hu; Meng Guo; Chang-Gui Li; Kai Chu; Wen-Gang He; Jing Zhang; Jian-Xiang Gu; Juan Li; Hui Zhao; Xiang-Hong Wu; BiZhen Lin; Zhi-Jie Lin; et al. (Science China Life Sciences, 2020)

Serum Uric Acid Levels and Risk of Intracranial Atherosclerotic Stenosis: A Cross-Sectional Study - Lin Li; Jun-Xia Zhu; Xiao-He Hou; Ya-Hui Ma; Wei Xu; Chen-Chen Tan; Fu-Rong Sun; Hong-Qi Li; Qiang Dong; Lan Tan; Jin-Tai Yu (Neurotoxicity Research, 2020)

Endometrial autophagy is essential for embryo implantation during early pregnancy - Yan Su; Juan-Juan Zhang; Jun-Lin He; Xue-Qing Liu; Xue-Mei Chen; Yu-Bin Ding; Chao Tong; Chuan Peng; Yan-Qing Geng; Ying-Xiong Wang; Ru-Fei Gao (Journal of Molecular Medicine, 2020)

A new DRP-4DVar-based coupled data assimilation system for decadal predictions using a fast online localization technique - Yujun He; Bin Wang; Wenyu Huang; Shiming Xu; Yong Wang; Li Liu; Lijuan Li; Juanjuan Liu; Yongqiang Yu; Yanluan Lin; Xiaomeng Huang; Yiran Peng (Climate Dynamics, 2020)

Daily minimum temperature and precipitation control on spring phenology in arid‐mountain ecosystems in China - Jun Du; Kai Li; Zhibin He; Longfei Chen; Pengfei Lin; Xi Zhu (International Journal of Climatology, 2020)
Climate anomaly has caused substantial shifts in phenology of mountain ecosystems, but the underlying mechanism of phenological responses to climate change is still not well understood. In essence, the abundance of vegetation communities increases the complexity of phenology‐climate relationships, leading to a certain limitation in predictions of future dynamics among different vegetation types using a unified model. In this study, we focused on the climatic constraints on spring phenology in arid mountains (AMs) of China, and emphasis was laid on accurate representation of mechanisms that control phenology across different vegetation types. We Firstly explored spatio‐temporal variations in satellite‐derived estimates of starting date of vegetation growing season (SOS) over the period 2000–2015 using moderate‐resolution imaging spectro‐radiometer (MODIS) normalized difference vegetation index (NDVI). Phenological models in response to climate variability were then established by using mixed‐effect models based on satellite observations and an extensive dataset of climatic measurements. Our results showed that the climatic regulation on SOS varied greatly over vegetation types. More climatic factors that regulate phenological development were found in grassland than forest and shrubland. At ecosystem level, two critical climate factors, daily minimum temperature ( T min ) and precipitation, explained 74–95% of total variability in predicted SOS. The observed sensitivity to T min is expected to be closely linked with the risk of frost damage, while preseason precipitation determines water availability in spring. The varying ecosystem sensitivity revealed the different resilience and adaptability to changing climate among vegetation types, which have been linked to their eco‐physiological characteristics (e.g., water use efficiency) and environmental conditions (e.g., elevation). Overall, our results indicate a strong dependence of spring phenology on T min and precipitation, and create an opportunity for a more realistic representation of vegetation phenology and growth of AM plants in China in land surface models.

Alpine grassland plants grow earlier and faster but biomass remains unchanged over 35 years of climate change - Hao Wang; Huiying Liu; Guangmin Cao; Zhiyuan Ma; Yikang Li; Fawei Zhang; Xia Zhao; Xinquan Zhao; Lin Jiang; Nathan J. Sanders; Aimée T. Classen; Jin‐Sheng He (Ecology Letters, 2020)
Satellite data indicate significant advancement in alpine spring phenology over decades of climate warming, but corresponding field evidence is scarce. It is also unknown whether this advancement results from an earlier shift of phenological events, or enhancement of plant growth under unchanged phenological pattern. By analyzing a 35‐year dataset of seasonal biomass dynamics of a Tibetan alpine grassland, we show that climate change promoted both earlier phenology and faster growth, without changing annual biomass production. Biomass production increased in spring due to a warming‐induced earlier onset of plant growth, but decreased in autumn due mainly to increased water stress. Plants grew faster but the fast‐growing period shortened during the mid‐growing season. These findings provide the first in situ evidence of long‐term changes in growth patterns in alpine grassland plant communities, and suggest that earlier phenology and faster growth will jointly contribute to plant growth in a warming climate.

Effects of simulated nitrogen deposition on Phyllostachys edulis (Carr.) seedlings under different watering conditions: is seedling drought tolerance related to nitrogen metabolism? - Wenhui Shi; Lin Lin; Shanlu Shao; Anguo He; Yeqing Ying (Plant and Soil, 2020)

Anatomical reduction and precise internal fixation of intra-articular fractures of the distal radius with virtual X-ray and 3D printing - Jing Xu; Guodong Zhang; Zaopeng He; Shizhen Zhong; Yongshao Chen; Chunrong Wei; Yudong Zheng; Haibin Lin; Wei Li; Wenhua Huang (Physical and Engineering Sciences in Medicine, 2020)
To evaluate and precisely internal fix intra-articular distal radial fracture (IDRF) using the virtual X-ray and three-dimensional (3D) printing technologies. Twenty-one patients with IDRF were recruited, and the data from digital design group (DDG) and real surgery group (RSG) were collected and analyzed. In DDG, the data from thin-slice computed tomography scan, virtual X-ray measurement parameters, including volar tilt, palmar tilt, radius length (D1), ulnar variation (D2), locking plate position parameter (D3) and distance between key nail and joint surface (D4) were collected. The bone was virtually fixed with the locking plate, and the final model of radius with the screw was obtained by 3D printing. In RSG, the locking plate was precisely pre-bended and used in surgery. During the surgery, the key K-wire was accurately placed and the locking plate was adjusted with the aid of the U-shaped navigation arm. The C-arm was used to observe the positions of key K-wires and the locking plate, and the same above-mentioned parameters were measured intra- and post-operatively. The data from RSG and DDG were compared statistically by t test. This approach proved to be successful in all 21 patients, and none of the screws pierced through the wrist joint surface. All the measured parameters, including the volar tilt, palmar tilt, D1–4, in RSG were not significantly different from preoperative DDG data. Virtual X-ray measurement of anatomical reduction parameters and 3D printing can help the anatomical reduction and precise internal fixation by providing quantitative references, preoperatively, intraoperatively and postoperatively.

Rabies Virus Pseudotyped with CVS-N2C Glycoprotein as a Powerful Tool for Retrograde Neuronal Network Tracing - Xutao Zhu; Kunzhang Lin; Qing Liu; Xinpei Yue; Huijie Mi; Xiaoping Huang; Xiaobin He; Ruiqi Wu; Danhao Zheng; Dong Wei; Liangliang Jia; Weilin Wang; et al. (Neuroscience Bulletin, 2020)

Combined GWAS and QTL analysis for dissecting the genetic architecture of kernel test weight in maize - Xiaoxiang Zhang; Zhongrong Guan; Lei Wang; Jun Fu; Yinchao Zhang; Zhaoling Li; Langlang Ma; Peng Liu; Yanling Zhang; Min Liu; Peng Li; Chaoying Zou; et al. (Molecular Genetics and Genomics, 2020)

Hostaflavanol A, a new anti-inflammatory and antioxidant activities flavanol from the flowers of Hosta plantaginea - Li Yang; Yi-min Lin; Zhong-wei He; Ting-fang Zhang; Yu Li; Xiao-tong Xie; Yi-feng Wu; Jun-wei He (Medicinal Chemistry Research, 2020)

Involvement of the JNK signaling in granular corneal dystrophy by modulating TGF-β-induced TGFBI expression and corneal fibroblast apoptosis - Danyao Nie; Xinhua Liu; Yuan Wang; Wenling He; Ming Li; Yun Peng; Jing Zhang; Liangnan Sun; Zonghui Yan; Lin Ye (In Vitro Cellular & Developmental Biology - Animal, 2020)

Screening for proteins interacting with the perilipin-like protein CAP20 by a yeast two-hybrid system and identification of a protein kinase a catalytic subunit as an interacting protein in Colletotrichum siamense - Jiyuan Wang; Xiaoyu Zhao; Xiaomiao Liao; Qiguang He; Xiao Li; Wenbo Liu; Ziping Yang; Yu Zhang; Chunhua Lin; Weiguo Miao (European Journal of Plant Pathology, 2020)

Preparation of a novel iron-based biochar composite for removal of hexavalent chromium in water - Luyao Qin; Li He; Wenjie Yang; Aijun Lin (Environmental Science and Pollution Research, 2020)

Intensity and daily pattern of passenger vehicle use by region and class in China: estimation and implications for energy use and electrification - Shiqi Ou; Rujie Yu; Zhenhong Lin; Huanhuan Ren; Xin He; Steven Przesmitzki; Jessey Bouchard (Mitigation and Adaptation Strategies for Global Change, 2020)

Stilbenoids from aerial parts of Dendrobium plicatile - Dan-Na Chen; Yu-Ye Wang; Wen-Jian Liu; Yue-Juan Chen; Ya-Ping Wu; Jing-Xian Wang; Feng He; Lin Jiang (Natural Product Research, 2020)

Molecular characterization of the Krüppel-homolog 1 and its role in ovarian development in Sogatella furcifera (Hemiptera: Delphacidae) - Kui Hu; Ping Tian; Lu Yang; Yan Tang; Lin Qiu; Hualiang He; Wenbing Ding; Youzhi Li (Molecular Biology Reports, 2020)

Growth of comammox Nitrospira is inhibited by nitrification inhibitors in agricultural soils - Chaoyu Li; Hang-Wei Hu; Qing-Lin Chen; Deli Chen; Ji-Zheng He (Journal of Soils and Sediments, 2020)

First report of tobacco rattle virus in hydrangea in China - Zhao-Lin Ji; Peng-Xiang Zhu; Gen-He He; Yong-Hui Liao; Feng Zhu (Journal of Plant Pathology, 2020)

Occurrence of chilli veinal mottle virus in Lycopersicon esculentum in Jiangxi Province in China - Yong-Hui Liao; Gen-He He; Zhao-Lin Ji; Feng Zhu (Journal of Plant Pathology, 2020)

Novel mutations in SPEF2 causing different defects between flagella and cilia bridge: the phenotypic link between MMAF and PCD - Chaofeng Tu; Hongchuan Nie; Lanlan Meng; Weili Wang; Haiyu Li; Shimin Yuan; Dehua Cheng; Wenbin He; Gang Liu; Juan Du; Fei Gong; Guangxiu Lu; et al. (Human Genetics, 2020)

Crystal structure of impurity-free rhodochrosite (MnCO3) and thermal expansion properties - Wen Liang; Lin Li; Rui Li; Yuan Yin; Zeming Li; Xiqiang Liu; Shuangmin Shan; Yu He; Yong Meng; Zengsheng Li; Heping Li (Physics and Chemistry of Minerals, 2020)

Development of Climate and Earth System Models in China: Past Achievements and New CMIP6 Results - Tianjun Zhou; Ziming Chen; Liwei Zou; Xiaolong Chen; Yongqiang Yu; Bin Wang; Qing Bao; Ying Bao; Jian Cao; Bian He; Shuai Hu; Lijuan Li; et al. (Journal of Meteorological Research, 2020)

Macrobenthic communities on the continental shelf of the Prydz Bay, East Antarctica - Kun Liu; Heshan Lin; Xuebao He; Yaqin Huang; Zhong Li; Junhui Lin; Jianfeng Mou; Shuyi Zhang; Jianjun Wang; Jun Sun (Acta Oceanologica Sinica, 2020)

Glutamate and aspartate alleviate testicular/epididymal oxidative stress by supporting antioxidant enzymes and immune defense systems in boars - Wenjie Tang; Jian Wu; Shunshun Jin; Liuqin He; Qinlu Lin; Feijun Luo; Xingguo He; Yanzhong Feng; Binsheng He; Pingping Bing; Tiejun Li; Yulong Yin (Science China Life Sciences, 2020)

Complexin I knockout rats exhibit a complex neurobehavioral phenotype including profound ataxia and marked deficits in lifespan - Yang Xu; Xiao-Ming Zhao; Jia Liu; Yang-Yang Wang; Liu-Lin Xiong; Xiu-Ying He; Ting-Hua Wang (Pflügers Archiv - European Journal of Physiology, 2020)

Adverse effects of subchronic exposure to cooking oil fumes on the gonads and the GPR30-mediated signaling pathway in female rats - Xiaoyang Zhang; Yonghua He; Quanhui Lin; Lili Huang; Qunwei Zhang; Youqiong Xu (Molecular & Cellular Toxicology, 2020)
Background Cooking oil fumes (COFs) are composed of particulate matter, polycyclic aromatic hydrocarbons, volatile organic compounds, aldehydes, and ketones, and are currently a global health concern. Some agents in COFs are mutagenic and carcinogenic. However, only a few reports have addressed the hazardous effects of COF exposure on the female reproductive system. In this study, we explored the effects of subchronic exposure to COFs on female gonads in vivo and the possible involvement of the G-protein-coupled receptor 30 signaling pathway. Methods COFs were generated by heating commercially available canola oil in an iron pot. Adult female Wistar rats at 2 months of age were exposed to COFs at 32 mg/m 3 for 0, 0.5, 1, 2, or 4 h/day for 56 days. The estrous cycle in rats was studied twice at 7:00 a.m. and 7:00 p.m. on the 43rd treatment day until the current estrous cycle was complete. The rat body weight was measured before the experiment and at day 56 post-exposure. At the end of the experiment, rat blood was collected for gonadal hormone assay, and ovaries were collected for histology and mRNA isolation. The mRNA levels of GPR30, EGFR, STAT3, and ERK were determined by quantitative RT-PCR. Results At a concentration of 32.21 ± 5.11 mg/m3, COF exposure extended the estrous cycle in rats, and ovary coefficient decreased. COFs showed various effects on the sex hormone levels and follicles, depending on its exposure level. Exposure to COFs led to the changes in mRNA levels of the G-protein-coupled receptor 30 (GPR30), epidermal growth factor receptor (EGFR), signal transducer and activator of transcription 3 (STAT3), and extracellular signal-regulated kinase (ERK). Conclusion This study indicated that cooking oil fume exposure disrupted the estrous cycle, sex hormone patterns, and follicle development in female rats in a dose-dependent manner. These adverse effects of cooking oil fumes on female reproductive health were correlated with the G-protein-coupled receptor 30-mediated signaling pathway. Highlights Subchronic exposure to COFs for 56 days had gonadal toxicity in female rats, that disrupted the estrous cycle, sex hormone patterns, and follicle development in a dose-dependent manner. Reproductive endocrine disruption might be one of the female gonadotoxicity mechanisms of COFs. These adverse effects of COFs on female reproductive health were correlated with the GPR30-mediated signaling pathway.