Vertical and horizontal distributions of clinical antibiotic resistance genes and bacterial communities in Danjiangkou Reservoir, China - Chunxia Jiang; Xiong Pan; Hans-Peter Grossart; Li Lin; Jingya Shi; Yuyi Yang (Environmental Science and Pollution Research, 2021)

Bacterial community variations in the South China Sea driven by different chemical conditions - Fu-lin Sun; You-Shao Wang; Mei-Lin Wu; Cui-Ci Sun; Zhao-Yu Jiang; Hao Cheng; Jiao Fei (Ecotoxicology, 2021)

Population, Reproductive and Fishery Dynamics of Spotted Box Crab (Calappa philargius), a New Claw-Only Fishery Species, in the Southern Taiwan Strait, China - Bai-an Lin; Yan Jiang; Robert Boenish; Qing Xu; Min Liu (Frontiers in Marine Science, 2021)
The spotted box crab Calappa philargius (Calappidae) is an increasingly consumed species in China, mainly sourced from a claw-only fishery. Being a not well-characterized species in the literature, this study is warranted to inform sustainable management approaches. Here we report on the first in-depth overview on biology and fishery dynamics of C. philargius in the southern Taiwan Strait of China. Whole body crabs ( N = 1,009) were collected monthly from January to December 2019 from trawlers, operating in the southern Taiwan Strait; sample collection was absent from May to July because of the national fishing moratorium regulation. Sex ratio, growth pattern, size at maturity and fecundity were estimated. The overall male: female ratio was 1: 1.47, significantly differing from the 1: 1 ( p < 0.01); monthly sex ratio variations were also significant ( p < 0.01), suggesting possible seasonal sexual segregation. We found the carapace widths (CW) of males were significantly larger than those of females ( p < 0.01). Based on the occurrence and percentages of berried females, we identified twin spawning events in January–April and August–October with the overall peak occurring in February. Size at 50% female maturity was 11.47 cm CW. Female absolute fecundity was significantly related to CW via a power function relationship ( N = 14, p < 0.01). The estimated average claw yield was 36.28 ± 3.07% of the whole body weight ( N = 95), irrespective of sex and size ( p > 0.5). Capture and trade data of C. philargius using trawl and trap fishing gears were documented to characterize claw-only fishery dynamics for future research and sustainable use.

Master regulator NtrC controls the utilization of alternative nitrogen sources in Pseudomonas stutzeri A1501 - Zhimin Yang; Qin Li; Yongliang Yan; Xiubin Ke; Yueyue Han; Shaoyu Wu; Fanyang Lv; Yahui Shao; Shanshan Jiang; Min Lin; Yunhua Zhang; Yuhua Zhan (World Journal of Microbiology and Biotechnology, 2021)
Pseudomonas stutzeri A1501 is a model strain used to study associative nitrogen fixation, and it possesses the nitrogen regulatory NtrC protein in the core genome. Nitrogen sources represent one of the important factors affecting the efficiency of biological nitrogen fixation in the natural environment. However, the regulation of NtrC during nitrogen metabolism in P. stutzeri A1501 has not been clarified. In this work, a phenotypic analysis of the ntrC mutant characterized the roles of NtrC in nitrogen metabolism and the oxidative stress response of P. stutzeri A1501. To systematically identify NtrC-controlled gene expression, RNA-seq was performed to further analyse the gene expression differences between the wild-type strain and the ∆ ntrC mutant under nitrogen fixation conditions. A total of 1431 genes were found to be significantly altered by ntrC deletion, among which 147 associative genes had NtrC-binding sites, and the pathways for nitrogen fixation regulation, nitrogenous compound acquisition and catabolism and nitrate assimilation were discussed. Furthermore, the oxidative stress-related gene ( katB ), which was upregulated by ntrC deletion, was suggested to be a potential target gene of NtrC, thus highlighting the importance of NtrC in nitrogenase protection against oxygen damage. Based on these findings, we propose that NtrC is a high-ranking element in the regulatory network of P. stutzeri A1501 that controls a variety of nitrogen metabolic and oxidative stress responsive traits required for adaptation to complex rhizosphere environments.

Correction to: Biomimetic Biphasic Electrospun Scaffold for Anterior Cruciate Ligament Tissue Engineering - Ya Tang; Jialiang Tian; Long Li; Lin Huang; Quan Shen; Shanzhu Guo; Yue Jiang (Tissue Engineering and Regenerative Medicine, 2021)

Biomimetic Biphasic Electrospun Scaffold for Anterior Cruciate Ligament Tissue Engineering - Ya Tang; Jialiang Tian; Long Li; Lin Huang; Quan Shen; Shanzhu Guo; Yue Jiang (Tissue Engineering and Regenerative Medicine, 2021)

The Decision Strategies of Adolescents with Different Emotional Stabilities in Unfair Situations - Yajing Si; Lin Jiang; Chanlin Yi; Qi Zhang; Cunbo Li; Jing Yu; Peiyang Li; Qiang Liu; Feng Wan; Fali Li; Dezhong Yao; Peng Xu (Neuroscience Bulletin, 2021)

Complement C3 Aggravates Post-epileptic Neuronal Injury Via Activation of TRPV1 - Guang-Tong Jiang; Lin Shao; Shuo Kong; Meng-Liu Zeng; Jing-Jing Cheng; Tao-Xiang Chen; Song Han; Jun Yin; Wan-Hong Liu; Xiao-Hua He; Yu-Min Liu; Lanzi Gongga; et al. (Neuroscience Bulletin, 2021)

Circ_0020093 ameliorates IL-1β-induced apoptosis and extracellular matrix degradation of human chondrocytes by upregulating SPRY1 via targeting miR-23b - Mingli Feng; Lin Jing; Jingbo Cheng; Shuai An; Jiang Huang; Qi Yan (Molecular and Cellular Biochemistry, 2021)
Osteoarthritis (OA) is a chronic disease characterized by articular cartilage degeneration and uncontrolled chondrocyte apoptosis. At present, accumulating evidence introduces that circular RNA (circRNA) is involved in the development of OA. The aim of our study was to explore the role and the functional mechanism of circ_0020093 in OA cell model. Human chondrocytes were treated with interleukin-1 beta (IL-1β) to construct OA model. The expression of circ_0020093, miR-23b, and Sprouty 1 (SPRY1) mRNA was measured by quantitative real-time polymerase chain reaction (qRT-PCR). Cell apoptosis was assessed by flow cytometry assay. The expression of extracellular matrix (ECM)-associated markers and SPRY1 protein level was detected by qRT-PCR and Western blot. Bioinformatics analysis-predicted relationship between miR-23b and circ_0020093 or SPRY1 was further verified by dual-luciferase reporter assay and RNA pull-down assay. In this study, we found that the expression of circ_0020093 and SPRY1 was declined, while miR-23b expression was elevated in IL-1β-treated chondrocytes. IL-1β induced chondrocyte apoptosis and ECM degradation, while these negative effects were alleviated by circ_0020093 overexpression or miR-23b inhibition. MiR-23b was a target of circ_0020093, and SPRY1 was a downstream target of miR-23b. Rescue experiments showed that miR-23b enrichment reversed the role of circ_0020093 overexpression, and SPRY1 knockdown also reversed the effects of miR-23b inhibition. Importantly, circ_0020093 positively regulated SPRY1 expression by targeting miR-23b. In conclusion, circ_0020093 ameliorates IL-1β-induced apoptosis and ECM degradation of human chondrocytes by regulating the miR-23b/SPRY1 axis.

Occurrence and removal of antibiotics, antibiotic resistance genes, and bacterial communities in hospital wastewater - Shijie Yao; Jianfeng Ye; Qing Yang; Yaru Hu; Tianyang Zhang; Lei Jiang; Salvator Munezero; Kuangfei Lin; Changzheng Cui (Environmental Science and Pollution Research, 2021)

Added value of kilometer-scale modeling over the third pole region: a CORDEX-CPTP pilot study - Xu Zhou; Kun Yang; Lin Ouyang; Yan Wang; Yaozhi Jiang; Xin Li; Deliang Chen; Andreas Prein (Climate Dynamics, 2021)

Damage mechanism of tunnels in the high-content salt rock stratum - Ping Zhou; Jinyi Li; Yifan Jiang; Feicong Zhou; Ming Lin; Jiayong Lin; Zhijie Wang (Bulletin of Engineering Geology and the Environment, 2021)

Rockburst response in hard rock owing to excavation unloading of twin tunnels at great depth - Fan Feng; Xibing Li; Lin Luo; Xingdong Zhao; Shaojie Chen; Ning Jiang; Wanpeng Huang; Yajun Wang (Bulletin of Engineering Geology and the Environment, 2021)

Protective Effects of Sodium Para-aminosalicylic Acid on Manganese-Induced Damage in Rat Pancreas - Xiaojuan Zhu; Bingyan Xie; Dianyin Liang; Wenxia Qin; Lin Zhao; Yue Deng; Pingjing Wen; Fang Xu; Michael Aschner; Yueming Jiang; Shiyan Ou (Biological Trace Element Research, 2021)

Development of a dual-labeled, hydrolysis probe-based, real-time quantitative PCR assay for detection of both genotypes of duck circovirus-1 (DuCV-1) and DuCV-2 - Lin Zhang; Wenming Jiang; Fuyou Zhang; Yang Li; Jinping Li; Shaobo Liang; Xiaohui Yu; Cheng Peng; Shuo Liu; Jingjing Wang; Shuhong Sun; Hualei Liu (Virus Genes, 2021)

Molecular Cloning and Characterization of FAD6 Gene from Chia (Salvia hispanica L.) - Yufei Xue; Lejing Li; Xuemei Liu; Huanhuan Jiang; Yanping Zhao; Songzhen Wei; Na Lin; Yourong Chai (Biochemical Genetics, 2021)

Characterization of a novel botoulivirus isolated from the phytopathogenic fungus Sclerotinia sclerotiorum - Fan Mu; Jichun Jia; Yunxiang Xue; Daohong Jiang; Yanping Fu; Jiasen Cheng; Yang Lin; Jiatao Xie (Archives of Virology, 2021)

Developing urinary pyrrole–amino acid adducts as non-invasive biomarkers for identifying pyrrolizidine alkaloids-induced liver injury in human - Lin Zhu; Chunyuan Zhang; Wei Zhang; Qingsu Xia; Jiang Ma; Xin He; Yisheng He; Peter P. Fu; Wei Jia; Yuzheng Zhuge; Ge Lin (Archives of Toxicology, 2021)

Ambient climate determines the directional trend of community stability under warming and grazing - Peipei Liu; Wangwang Lv; Jianping Sun; Caiyun Luo; Zhenhua Zhang; Xiaoxue Zhu; Xingwu Lin; Jichuang Duan; Guangping Xu; Xiaofeng Chang; Yigang Hu; Qiaoyan Lin; et al. (Global Change Biology, 2021)
Changes in ecological processes over time in ambient treatments are often larger than the responses to manipulative treatments in climate change experiments. However, the impacts of human‐driven environmental changes on the stability of natural grasslands have been typically assessed by comparing differences between manipulative plots and reference plots. Little is known about whether or how ambient climate regulates the effects of manipulative treatments and their underlying mechanisms. We collected two datasets, one a 36‐year long‐term observational dataset from 1983 to 2018, and the other a 10‐year manipulative asymmetric warming and grazing experiment using infrared heaters with moderate grazing from 2006 to 2015 in an alpine meadow on the Tibetan Plateau. The 36‐year observational dataset shows that there was a nonlinear response of community stability to ambient temperature with a positive relationship between them due to an increase in ambient temperature in the first 25 years and then a decrease in ambient temperature thereafter. Warming and grazing decreased community stability with experiment duration through an increase in legume cover and a decrease in species asynchrony, which was due to the decreasing background temperature through time during the 10‐year experiment period. Moreover, the temperature sensitivity of community stability was higher under the ambient treatment than under the manipulative treatments. Therefore, our results suggested that ambient climate may control the directional trend of community stability while manipulative treatments may determine the temperature sensitivity of the response of community stability to climate relative to the ambient treatment. Our study emphasizes the importance of the context dependency of the response of community stability to human‐driven environmental changes.

Isolation and evaluation of the biocontrol potential of Talaromyces spp. against rice sheath blight guided by soil microbiome - Aqleem Abbas; Yanping Fu; Zheng Qu; Huizhang Zhao; Yongjian Sun; Yang Lin; Jiatao Xie; Jiasen Cheng; Daohong Jiang (Environmental Microbiology, 2021)
Summary Rice sheath blight caused by Rhizoctonia solani is the major disease of rice that seriously threatens food security worldwide. Efficient and eco‐friendly biological approaches are urgently needed since no resistant cultivars are available. In this study, fallow and paddy soils were initially subjected to microbiome analyses, and the results showed that Talaromyces spp. were significantly more abundant in the paddy soil, while Trichoderma spp. were more abundant in the fallow soil, suggesting that Talaromyces spp. could live and survive better in the paddy soil. Five Talaromyces isolates, namely, TF‐04, TF‐03, TF‐02, TF‐01 and TA‐02, were isolated from the paddy soil using sclerotia of R . solani as baits and were further evaluated for their activity against rice sheath blight. These isolates efficiently parasitized the hyphae and rotted the sclerotia even at higher water contents in the sterilized sand and the soil. Isolate TF‐04 significantly promoted rice growth, reduced the severity of rice sheath blight and increased the rice yield under outdoor conditions. Defence‐related genes were upregulated and enzyme activities were enhanced in rice treated with isolate TF‐04. Our research supplies a microbiome‐guided approach to screen biological control agents and provides Talaromyces isolates to biologically control rice sheath blight.

Consistently positive effect of species diversity on ecosystem, but not population, temporal stability - Qianna Xu; Xian Yang; Ying Yan; Shaopeng Wang; Michel Loreau; Lin Jiang (Ecology Letters, 2021)
Despite much recent progress, our understanding of diversity–stability relationships across different study systems remains incomplete. In particular, recent theory clarified that within‐species population stability and among‐species asynchronous population dynamics combine to determine ecosystem temporal stability, but their relative importance in modulating diversity‐ecosystem temporal stability relationships in different ecosystems remains unclear. We addressed this issue with a meta‐analysis of empirical studies of ecosystem and population temporal stability in relation to species diversity across a range of taxa and ecosystems. We show that ecosystem temporal stability tended to increase with species diversity, regardless of study systems. Increasing diversity promoted asynchrony, which, in turn, contributed to increased ecosystem stability. The positive diversity–ecosystem stability relationship persisted even after accounting for the influences of environmental covariates (e.g., precipitation and nutrient input). By contrast, species diversity tended to reduce population temporal stability in terrestrial systems but increase population temporal stability in aquatic systems, suggesting that asynchronous dynamics among species are essential for stabilizing diverse terrestrial ecosystems. We conclude that there is compelling empirical evidence for a general positive relationship between species diversity and ecosystem‐level temporal stability, but the contrasting diversity–population temporal stability relationships between terrestrial and aquatic systems call for more investigations into their underlying mechanisms.

Impacts of Marine Heatwaves on Algal Structure and Carbon Sequestration in Conjunction With Ocean Warming and Acidification - Guang Gao; Xin Zhao; Meijia Jiang; Lin Gao (Frontiers in Marine Science, 2021)
As the ocean warms, the frequency, duration, intensity, and range of marine heatwaves (MHWs) increase. MHWs are becoming a severe challenge for marine ecosystems. However, our understanding in regard to their impacts on algal structure and carbon sequestration is still deficient or fragmentary, particularly when combined with ocean warming and acidification. In this paper, we reviewed the impacts of MHWs individually and combined with ocean warming and acidification on regime shift in algal community and carbon sequestration of both macroalgae and microalgae. Solid evidence shows that MHWs cause the decline of large canopy macroalgae and increase of turf-forming macroalgae in abundance, leading to the regime shift from kelp forests to seaweed turfs. Furthermore, increased grazing pressure on kelps due to tropicalization facilitates the expansion of turfs that prevent the recovery of kelps through plundering light and space. Meanwhile, MHWs could trigger microalgal blooms and the intensity of algal blooms is regulated by the severity of MHWs and nutrient availability. MHWs could lead to the decrease of carbon burial and sequestration by canopy-forming macroalgae due to depressed growth and increased mortality. The effects of MHWs on the productivity of microalgae are latitude-dependent: negative effects at low and mid-latitudes whilst positive effects at high latitudes. Ocean warming and acidification may accelerate the shift from kelps to turfs and thus decrease the carbon sequestration by canopy-forming macroalgae further. We propose that MHWs combined with ocean warming and acidification would reduce the biodiversity and facilitate the thriving of morphologically simple, ephemeral and opportunistic turfs and diatoms in coastal oceans, and phytoplankton with smaller size in open oceans. This structure shift would not be in favor of long-term carbon sequestration. Future studies could be conducted to test this hypothesis and investigate the impacts of MHWs on carbon sequestration under future ocean conditions.

A new monoterpene-lactone with neuroprotective activity from corn silk - Wei-Yu Zhou; Tian-Ming Lv; Zi-Lin Hou; Ming Bai; Bin Lin; Xiao-Xiao Huang; Shao-Jiang Song (Natural Product Research, 2021)

Identification of a recessive gene YrZ15-1370 conferring adult plant resistance to stripe rust in wheat-Triticum boeoticum introgression line - Minghu Zhang; Xin Liu; Ting Peng; Dinghao Wang; Dongyu Liang; Hongyu Li; Ming Hao; Shunzong Ning; Zhongwei Yuan; Bo Jiang; Xuejiao Chen; Xue Chen; et al. (Theoretical and Applied Genetics, 2021)

Structural basis for the functional properties of the P2X7 receptor for extracellular ATP - Lin-Hua Jiang; Emily A. Caseley; Steve P. Muench; Sébastien Roger (Purinergic Signalling, 2021)
The P2X7 receptor, originally known as the P2Z receptor due to its distinctive functional properties, has a structure characteristic of the ATP-gated ion channel P2X receptor family. The P2X7 receptor is an important mediator of ATP-induced purinergic signalling and is involved the pathogenesis of numerous conditions as well as in the regulation of diverse physiological functions. Functional characterisations, in conjunction with site-directed mutagenesis, molecular modelling, and, recently, structural determination, have provided significant insights into the structure–function relationships of the P2X7 receptor. This review discusses the current understanding of the structural basis for the functional properties of the P2X7 receptor.

Assessing tree height and density of a young forest using a consumer unmanned aerial vehicle (UAV) - Zhenbang Hao; Lili Lin; Christopher J. Post; Yusen Jiang; Minghui Li; Nibin Wei; Kunyong Yu; Jian Liu (New Forests, 2021)

Comparison of pramipexole and levodopa/benserazide combination therapy versus levodopa/benserazide monotherapy in the treatment of Parkinson’s disease: a systematic review and meta-analysis - De-Qi Jiang; Qing-Min Zang; Li-Lin Jiang; Yan Wang; Ming-Xing Li; Jing-Yi Qiao (Naunyn-Schmiedeberg's Archives of Pharmacology, 2021)

Differential DNA Methylation Profiles in Patients with Temporal Lobe Epilepsy and Hippocampal Sclerosis ILAE Type I - Wang Zhang; Haiyang Wang; Binchao Liu; Miaomiao Jiang; Yifei Gu; Shi Yan; Xian Han; Alicia Y. Hou; Chongyang Tang; Zhenfeng Jiang; Hong Shen; Meng Na; et al. (Journal of Molecular Neuroscience, 2021)

Antimicrobial Activity of Natural Plant Compound Carvacrol Against Soft Rot Disease Agent Dickeya zeae - Shangbo Jiang; Jingxin Zhang; Qiyun Yang; Dayuan Sun; Xiaoming Pu; Huifang Shen; Qiqin Li; Zhongwen Wang; Birun Lin (Current Microbiology, 2021)

Sodium P-aminosalicylic Acid Inhibits Manganese-Induced Neuroinflammation in BV2 Microglial Cells via NLRP3-CASP1 Inflammasome Pathway - Yuanyuan Fang; Dongjie Peng; Yuan Liang; Lili Lu; Junyan Li; Lin Zhao; Shiyan Ou; Shaojun Li; Michael Aschner; Yueming Jiang (Biological Trace Element Research, 2021)

A Multilevel Recognition Model of Water Inrush Sources: A Case Study of the Zhaogezhuang Mining Area - Gang Lin; Dong Jiang; Donglin Dong; Jingying Fu; Xiang Li (Mine Water and the Environment, 2021)

Combination of optimized tissue engineering bone implantation with heel-strike like mechanical loading to repair segmental bone defect in New Zealand rabbits - Cong Zhu; Jianbiao Lin; Huixiang Jiang; Jianting Gao; Mingming Gao; Benwen Wu; Weibin Lin; Guofeng Huang; Zhenqi Ding (Cell and Tissue Research, 2021)

Thermal Characteristics, Kinetics, and Volatility of Co-Combustion of Sewage Sludge and Rice Husk - Chengxin Wang; Haobo Bi; Qizhao Lin; Chunlong Jiang; Xuedan Jiang; Kesheng Meng (BioEnergy Research, 2021)

Ethylene‐regulated leaf lifespan explains divergent responses of plant productivity to warming among three hydrologically different growing seasons - Haiyan Ren; Guodong Han; Mai‐He Li; Cuiping Gao; Lin Jiang (Global Change Biology, 2021)
Leaf senescence is known to be regulated by the plant hormone ethylene, but how leaf lifespan responds to global environmental change and links to ecosystem‐level responses remains largely unexplored. Here we investigated the effects of climate warming and nitrogen addition on plant functional traits, plant hormone ethylene and net primary production in a 13‐year field experiment in a desert steppe. Across the last 3 years of the experiment (2016–2018), plant productivity increased under warming only in 2016, when there was above normal precipitation, but consistently increased with nitrogen addition. Warming enhanced net photosynthesis, leaf nitrogen and ethylene production and reduced leaf lifespan in 2016 (a wet year), but not in 2017 (a drought year); the effect of warming in 2018 (a year with normal precipitation) was opposite to 2016, likely due to the below‐normal precipitation in the mid‐growing season in 2018. Nitrogen addition led to increases in leaf nitrogen, ethylene production and net photosynthesis, and declines in leaf lifespan in 2016 and 2018, but not in 2017. The ethylene‐regulated lifespan was further evidenced by the addition of CoCl 2 (an ethylene biosynthesis inhibitor) that reduced ethylene production and prolonged lifespan. Structural equation modeling showed that leaf lifespan had a negative effect on plant productivity, both directly and indirectly via its negative effect on net photosynthesis, across all 3 years. Our results demonstrate the divergent responses of leaf lifespan and, in turn, plant productivity to warming under inter‐annual and intra‐annual precipitation variation, thus linking plant hormone production, functional traits and ecosystem functioning in the face of global environmental change.

A novel antisense long non‐coding RNA participates in asexual and sexual reproduction by regulating the expression of GzmetE in Fusarium graminearum - Jie Wang; Wenping Zeng; Jiatao Xie; Yanping Fu; Daohong Jiang; Yang Lin; Weidong Chen; Jiasen Cheng (Environmental Microbiology, 2021)
Summary Fusarium graminearum is an important worldwide pathogen that causes Fusarium head blight in wheat, barley, maize and other grains. LncRNAs play important roles in many biological processes, but little is known about their functions and mechanisms in filamentous fungi. Here, we report that a natural antisense RNA, GzmetE‐AS , is transcribed from the opposite strand of GzmetE . GzmetE encodes a homoserine O ‐acetyltransferase, which is important for sexual development and plant infection. The expression of GzmetE‐AS was increased significantly during the conidiation stage, while GzmetE was upregulated in the late stage of sexual reproduction. Overexpression of GzmetE‐AS inhibited the transcription of GzmetE . In contrast, the expression of GzmetE was significantly increased in GzmetE‐AS transcription termination strain GzmetE‐AS ‐T. Furthermore, GzmetE‐AS ‐T produced more perithecia and facilitated the ascospore discharge, resembling the phenotype of GzmetE overexpressing strains. However, overexpression of GzmetE‐AS in ∆dcl1/2 strain cannot inhibit the expression of GzmetE , and the GzmetE nat‐siRNA is also significantly reduced in ∆dcl1/2 mutant. Taken together, we have identified a novel antisense lncRNA GzmetE‐AS , which is involved in asexual and sexual reproduction by regulating its antisense gene GzmetE through RNAi pathway. Our findings reveal that the lncRNA plays critical roles in the development of F . graminearum .

Comparative Analysis of Two Approaches for Correcting the Systematic Ocean Temperature Bias of CAS-ESM-C - Mengjiao Du; Fei Zheng; Jiang Zhu; Renping Lin; Kan Yi (Journal of Marine Science and Engineering, 2021)
Currently, several ocean data assimilation methods have been adopted to increase the performance of air–sea coupled models, but inconsistent adjustments between the sea temperature with other oceanic fields can be introduced. In the coupled model CAS-ESM-C, inconsistent adjustments for ocean currents commonly occur in the tropical western Pacific and the eastern Indian Ocean. To overcome this problem, a new ensemble-based bias correction approach—a simple modification of the Ensemble Optimal Interpolation (EnOI) approach for multi-variable into a direct approach for a single variable—is proposed to minimize the model biases. Compared with the EnOI approach, this new approach can effectively avoid inconsistent adjustments. Meanwhile, the comparisons suggest that inconsistent adjustment mainly results from the unreasonable correlations between temperature and ocean current in the background matrix. In addition, the ocean current can be directly corrected in the EnOI approach, which can additionally generate biases for the upper ocean. These induced ocean biases can produce unreasonable ocean heat sinking and heat storage in the tropical western Pacific. It will generate incorrect ocean heat transmission toward the east, further amplifying the inconsistency introduced through the tropical air–sea interaction process.

Elevated pCO2 Impedes Succession of Phytoplankton Community From Diatoms to Dinoflagellates Along With Increased Abundance of Viruses and Bacteria - Ruiping Huang; Jiazhen Sun; Yunlan Yang; Xiaowen Jiang; Zhen Wang; Xue Song; Tifeng Wang; Di Zhang; He Li; Xiangqi Yi; Shouchang Chen; Nanou Bao; et al. (Frontiers in Marine Science, 2021)
Eutrophic coastal regions are highly productive and greatly influenced by human activities. Primary production supporting the coastal ecosystems is supposed to be affected by progressive ocean acidification driven by increasing CO 2 emissions. In order to investigate the effects of high p CO 2 (HC) on eutrophic plankton community structure and ecological functions, we employed 9 mesocosms and carried out an experiment under ambient (∼410 ppmv) and future high (1000 ppmv) atmospheric p CO 2 conditions, using in situ plankton community in Wuyuan Bay, East China Sea. Our results showed that HC along with natural seawater temperature rise significantly boosted biomass of diatoms with decreased abundance of dinoflagellates in the late stage of the experiment, demonstrating that HC repressed the succession from diatoms to dinoflagellates, a phenomenon observed during algal blooms in the East China Sea. HC did not significantly influence the primary production or biogenic silica contents of the phytoplankton assemblages. However, the HC treatments increased the abundance of viruses and heterotrophic bacteria, reflecting a refueling of nutrients for phytoplankton growth from virus-mediated cell lysis and bacterial degradation of organic matters. Conclusively, our results suggest that increasing CO 2 concentrations can modulate plankton structure including the succession of phytoplankton community and the abundance of viruses and bacteria in eutrophic coastal waters, which may lead to altered biogeochemical cycles of carbon and nutrients.

Upregulated SOCC and IP3R calcium channels and subsequent elevated cytoplasmic calcium signaling promote nonalcoholic fatty liver disease by inhibiting autophagy - Lin Zhang; Yifan Zhang; Yuanqing Jiang; Xiaobing Dou; Songtao Li; Hui Chai; Qianyu Qian; Miaojuan Wang (Molecular and Cellular Biochemistry, 2021)

Augmented BMP4 signal impairs tongue myogenesis - Jian Zhang; Chensheng Lin; Yingnan Song; Yanding Zhang; Jiang Chen (Journal of Molecular Histology, 2021)

Comparison of the Curative Effects of Hip Arthroplasty with Bio-Type Femoral Stem and Cemented Femoral Stem in Elderly Patients with Unstable Osteoporotic Intertrochanteric Femur Fractures - Xinxin Lin; Keqin Yang; Haitao Tan; Fengping Gan; Jianzhong Jiang (Journal of Medical and Biological Engineering, 2021)

Optimization of methane production in a swine manure–rice straw anaerobic co-digestion process with sycamore sawdust biochar application - B. Jiang; Y. Lin; Y. Lun; Z. Xu (International Journal of Environmental Science and Technology, 2021)

Correction to: Gyral-sulcal contrast in intrinsic functional brain networks across task performances - Lin Zhao; Tuo Zhang; Lei Guo; Tianming Liu; Xi Jiang (Brain Imaging and Behavior, 2021)

Bearing mechanism of a tunnel-type anchorage in a railway suspension bridge - Nan Jiang; Duo Wang; Jun Feng; Sheng-liang Zhang; Lin Huang (Journal of Mountain Science, 2021)

Porosity Prediction from Well Logs Using Back Propagation Neural Network Optimized by Genetic Algorithm in One Heterogeneous Oil Reservoirs of Ordos Basin, China - Lin Chen; Weibing Lin; Ping Chen; Shu Jiang; Lu Liu; Haiyan Hu (Journal of Earth Science, 2021)

Evaluation of Shale Reservoir Quality by Geophysical Logging for Shuijingtuo Formation of Lower Cambrian in Yichang Area, Central Yangtze - Xiaohong Chen; Lin Chen; Shu Jiang; An Liu; Shengyuan Luo; Hai Li; Peijun Li; Ping Chen (Journal of Earth Science, 2021)

Long‐term nitrogen input alters plant and soil bacterial, but not fungal beta diversity in a semiarid grassland - Weixing Liu; Lingli Liu; Xian Yang; Meifeng Deng; Zhou Wang; Pandeng Wang; Sen Yang; Ping Li; Ziyang Peng; Lu Yang; Lin Jiang (Global Change Biology, 2021)
Anthropogenic nitrogen (N) input is known to alter plant and microbial α‐diversity, but how N enrichment influences β‐diversity of plant and microbial communities remains poorly understood. Using a long‐term multilevel N addition experiment in a temperate steppe, we show that plant, soil bacterial and fungal communities exhibited different responses in their β‐diversity to N input. Plant β‐diversity decreased linearly as N addition increased, as a result of increased directional environmental filtering, where soil environmental properties largely explained variation in plant β‐diversity. Soil bacterial β‐diversity first increased then decreased with increasing N input, which was best explained by corresponding changes in soil environmental heterogeneity. Soil fungal β‐diversity, however, remained largely unchanged across the N gradient, with plant β‐diversity, soil environmental properties, and heterogeneity together explaining an insignificant fraction of variation in fungal β‐diversity, reflecting the importance of stochastic community assembly. Our study demonstrates the divergent effect of N enrichment on the assembly of plant, soil bacterial and fungal communities, emphasizing the need to examine closely associated fundamental components (i.e., plants and microorganisms) of ecosystems to gain a more complete understanding of ecological consequences of anthropogenic N enrichment.

A new ent -kaurane diterpene from Isodon henryi - Xue Jiang; Ling-Xia Zhang; Qing-Mei Feng; Hong Wu; Ya-Lin Liu; De-Qin Wang; Li-Ping Dai; Zhi-Min Wang (Natural Product Research, 2021)

Prenylated xanthones and biphenyls from Garcinia esculenta with antistaphylococcal activity - Dan Zheng; Hong Zhang; Jia-Ming Jiang; Yu-Yu Chen; Shi-Jie Wan; Zhi-Xiu Lin; Hong-Xi Xu (Natural Product Research, 2021)

Identification of a delayed leaf greening gene from a mutation of pummelo - Hui-Wen Yu; Zhi-Hao Lu; Xia Wang; Dan Liu; Jia-Xian He; Xiao-Lin Jiang; Ling-Jun Ke; Wen-Wu Guo; Xiu-Xin Deng; Qiang Xu (Science China Life Sciences, 2021)

A H2O-in-zircon perspective on the heterogeneous water content of crust-derived magmas in southern Tibet - Juntong Meng; Xiaoping Xia; Lin Ma; Ziqi Jiang; Jian Xu; Zexian Cui; Qing Yang; Wanfeng Zhang; Le Zhang (Science China Earth Sciences, 2021)

Comparative analysis of sRNAs, degradome and transcriptomics in sweet sorghum reveals the regulatory roles of miRNAs in Cd accumulation and tolerance - Weitao Jia; Kangqi Lin; Tengxue Lou; Juanjuan Feng; Sulian Lv; Ping Jiang; Ze Yi; Xuan Zhang; Duoliya Wang; Zijing Guo; Yetao Tang; Rongliang Qiu; et al. (Planta, 2021)

Quantitative Fluorescence Resonance Energy Transfer Analysis on the Direct Interaction of Activation-2b with Histone H3/Switch-3B Protein in Arabidopsis Mesophyll Protoplasts - Lu Gao; Fangrui Lin; Danlu Han; Jieming Jiang; Chengwei Yang; Zhengfei Zhuang; Tongsheng Chen (Journal of Fluorescence, 2021)

S100A14 inhibits cell growth and epithelial–mesenchymal transition (EMT) in prostate cancer through FAT1-mediated Hippo signaling pathway - Shaoqin Jiang; Yaru Zhu; Zhenlin Chen; Zhangcheng Huang; Bingqiao Liu; Yue Xu; Zhihao Li; Zequn Lin; Mengqiang Li (Human Cell, 2021)

Enhancement of sludge dewaterability by a magnetic field combined with coagulation/flocculation: a comparative study on municipal and citric acid–processing waste-activated sludge - Ning Ding; Xiao Wang; Lin Jiang; Jianxin Zhang; Yue Geng; Liming Dong; Hong Liu (Environmental Science and Pollution Research, 2021)

Anthracnose disease of Amomum villosum caused by Colletotrichum fructicola in China - Lisha Song; Wei Lin; Ni Jiang; Zhanjiang Zhang; Guiyu Tan; Shugen Wei (Journal of General Plant Pathology, 2021)

Glaciibacter flavus sp. nov., isolated from a lichen sample - De-Feng An; Long-Qian Jiang; Kun Zhang; Gui-Ding Li; Xin-Yu Wang; Ming-Guo Jiang; Lei Lang; Li-Song Wang; Johannes F. Imhoff; Cheng-Lin Jiang; Yi Jiang (Archives of Microbiology, 2021)

Molecular cloning and characterization of two plastidial Δ12 fatty acid desaturase cDNAs from Perilla frutescens - Yufei Xue; Huanhuan Jiang; Baojun Chen; Jiayi Jiang; Na Lin; Lejing Li; Xuemei Liu; Yourong Chai (Acta Physiologiae Plantarum, 2021)

Above‐ and belowground biodiversity jointly drive ecosystem stability in natural alpine grasslands on the Tibetan Plateau - Litong Chen; Lin Jiang; Xin Jing; Jiuluan Wang; Yu Shi; Haiyan Chu; Jin‐Sheng He (Global Ecology and Biogeography, 2021)
Aim Most existing studies that examined the biotic mechanisms of ecosystem stability have focused on aboveground biodiversity. Whether and how belowground biodiversity affects the stability of natural ecosystems is largely unknown. In the present study, we investigated the relationships between above‐ and belowground biodiversity and the temporal stability of grassland biomass production across a large gradient of soil and climatic conditions. Location Tibetan Plateau. Time period 2001–2016. Major taxa studied Alpine grass and soil bacteria, arbuscular mycorrhiza (AM) fungi and fauna. Methods We coupled a field biodiversity survey conducted in 54 alpine grassland ecosystems across the Tibetan Plateau with a satellite‐sensed proxy (enhanced vegetation index, EVI) of ecosystem productivity during 2001–2016. The temporal stability of primary productivity was calculated as the ratio of the mean annual peak EVI to the standard deviation of the annual peak EVI over this period. Plant diversity was determined using a classic vegetation survey approach, soil bacterial and AM fungal diversity were measured using a high‐throughput sequencing approach, and soil fauna was counted and identified at the order level after being extracted using a modified Berlese–Tullgren method. Results Our results demonstrated that both above‐ and belowground biodiversity were positively associated with ecosystem stability. Belowground biodiversity not only affected ecosystem stability directly, but also influenced it indirectly through plant diversity and soil fertility. Furthermore, soil pH, climate and its variability strongly influenced soil biodiversity, which in turn influenced ecosystem stability. Main conclusions Our study demonstrates the indispensable role of belowground biodiversity in regulating ecosystem stability, emphasizing the necessity of conserving this ‘hidden’ biodiversity in fragile alpine ecosystems facing ongoing environmental change.

Flavonoids from Artemisia rupestris and their synergistic antibacterial effects on drug-resistant Staphylococcus aureus - Jiang-Er Lan; Xiao-Jin Li; Xiao-Feng Zhu; Zhong-Lin Sun; Jian-Ming He; Mire Zloh; Simon Gibbons; Qing Mu (Natural Product Research, 2021)

Neuroprotective Effects of 2-Substituted 1, 3-Selenazole Amide Derivatives on Amyloid-Beta-Induced Toxicity in a Transgenic Caenorhabditis Elegans Model of Alzheimer’s Disease - Huiying Wang; Yuandong Yue; Haifeng Zhao; Hao Wu; Kai Jiang; Shuang Li; Meihua Zhao; Feng Lin (Neurotoxicity Research, 2021)

Different posterior hippocampus and default mode network modulation in young APOE ε4 carriers: a functional connectome-informed phenotype longitudinal study - Li Juan Zheng; Li Lin; U. Joseph Schoepf; Akos Varga-Szemes; Rock H. Savage; Han Zhang; Yun Fei Wang; Xin Yuan Zhang; Song Luo; Ya Liu; Gui Fen Yang; Guang Ming Lu; et al. (Molecular Neurobiology, 2021)

Trueperella pyogenes pyolysin inhibits lipopolysaccharide-induced inflammatory response in endometrium stromal cells via autophagy- and ATF6-dependent mechanism - Maozhen Qi; Jianguo Liu; Qingran Jiang; Hongyu Niu; Xinyu Wang; Dong Zhou; Pengfei Lin; Huatao Chen; Aihua Wang; Yaping Jin (Brazilian Journal of Microbiology, 2021)

Patients with first-episode untreated schizophrenia who experience concomitant visual disturbances and auditory hallucinations exhibit co-impairment of the brain and retinas—a pilot study - Chuanjun Zhuo; Bo Xiao; Feng Ji; Xiaodong Lin; Deguo Jiang; Hongjun Tian; Yong Xu; Wenqiang Wang; Ce Chen (Brain Imaging and Behavior, 2021)

Disrupted pathways from frontal-parietal cortex to basal ganglia and cerebellum in patients with unmedicated obsessive compulsive disorder as observed by whole-brain resting-state effective connectivity analysis – a small sample pilot study - Wei Liu; Minghui Hua; Jun Qin; Qiuju Tang; Yunyi Han; Hongjun Tian; Daxiang Lian; Zhengqing Zhang; Wenqiang Wang; Chunxiang Wang; Ce Chen; Deguo Jiang; et al. (Brain Imaging and Behavior, 2021)

Gyral-sulcal contrast in intrinsic functional brain networks across task performances - Lin Zhao; Tuo Zhang; Lei Guo; Tianming Liu; Xi Jiang (Brain Imaging and Behavior, 2021)

Metabolism-mediated cytotoxicity and genotoxicity of pyrrolizidine alkaloids - Yisheng He; Lin Zhu; Jiang Ma; Ge Lin (Archives of Toxicology, 2021)

Performance analysis of landslide susceptibility assessment under different factor-filtering models - Yangchun Li; Feikai Lin; Lianhui Lou; Jiang Li; Zhanya Xu; Shuang Zhu; Xiangang Luo; Guangjie Huo; Qianjun Zhao (Arabian Journal of Geosciences, 2021)

Temperature sensitivity of SOM decomposition is linked with a K‐selected microbial community - Hui Li; Shan Yang; Mikhail V. Semenov; Fei Yao; Ji Ye; Rencang Bu; Ruiao Ma; Junjie Lin; Irina Kurganova; Xugao Wang; Ye Deng; Irina Kravchenko; et al. (Global Change Biology, 2021)
Temperature sensitivity (Q 10 ) of soil organic matter (SOM) decomposition is a crucial parameter to predict the fate of soil carbon (C) under global warming. Nonetheless, the response pattern of Q 10 to continuous warming and the underlying mechanisms are still under debate, especially considering the complex interactions between Q 10 , SOM quality, and soil microorganisms. We examined the Q 10 of SOM decomposition across a mean annual temperature (MAT) gradient from −1.9 to 5.1°C in temperate mixed forest ecosystems in parallel with SOM quality and bioavailability, microbial taxonomic composition, and functional genes responsible for organic carbon decomposition. Within this temperature gradient of 7.0°C, the Q 10 values increased with MAT, but decreased with SOM bioavailability. The Q 10 values increased with the prevalence of K‐strategy of soil microbial community, which was characterized by: (i) high ratios of oligotrophic to copiotrophic taxa, (ii) ectomycorrhizal to saprotrophic fungi, (iii) functional genes responsible for degradation of recalcitrant to that of labile C, and (iv) low average 16S rRNA operon copy number. Because the recalcitrant organic matter was mainly utilized by the K‐strategists, these findings independently support the carbon quality‐temperature theory from the perspective of microbial taxonomic composition and functions. A year‐long incubation experiment was performed to determine the response of labile and recalcitrant C pools to warming based on the two‐pool model. The decomposition of recalcitrant SOM was more sensitive to increased temperature in southern warm regions, which might attribute to the dominance of K‐selected microbial communities. It implies that climate warming would mobilize the larger recalcitrant pools in warm regions, exacerbating the positive feedback between increased MAT and CO 2 efflux. This is the first attempt to link temperature sensitivity of SOM decomposition with microbial eco‐strategies by incorporating the genetic information and disentangling the complex relationship between Q 10 and soil microorganisms.

Recent advances in the application of metabolomics for food safety control and food quality analyses - Shubo Li; Yufeng Tian; Pingyingzi Jiang; Ying Lin; Xiaoling Liu; Hongshun Yang (Critical Reviews in Food Science and Nutrition, 2021)

Bone marrow-derived mesenchymal stem cells improve post-ischemia neurological function in rats via the PI3K/AKT/GSK-3β/CRMP-2 pathway - Xiaohui Lin; Hongbin Chen; Manli Chen; Ting Li; Yongxing Lai; Longzai Lin; Peiqiang Lin; Ji Liu; Yixian Zhang; Ronghua Chen; Houwei Du; Xinhong Jiang; et al. (Molecular and Cellular Biochemistry, 2021)

Construction of an infectious full-length cDNA clone of potato aucuba mosaic virus - Buyang Chen; Qi Lin; Yueyan Yin; Liangliang Jiang; Fang Wang; Shuzhen Hu; Xinyang Wu; Fei Xu; Jiejun Peng; Hongying Zheng; Chengqi Yan; Xiaohan Mo; et al. (Archives of Virology, 2021)

Study on characteristics of waterflooding in fractured reservoirs based on discrete fracture model - Fanle Meng; Junjian Li; Hanqiao Jiang; Lin Zhao; Linkai Li; Yan Qiao; Yu Zhou; Fei Xu (Arabian Journal of Geosciences, 2021)

Geological and climatic histories likely shaped the origins of terrestrial vertebrates endemic to the Tibetan Plateau - Jiekun He; Siliang Lin; Chenchen Ding; Jiehua Yu; Haisheng Jiang (Global Ecology and Biogeography, 2021)
Aim The Tibetan Plateau (TP) hosts many endemic species, but questions regarding when and from where these species originated have not been comprehensively answered. Here, we provide a synthesis of the biogeographical history of terrestrial vertebrates endemic to the TP and investigate the potential drivers of their spatio‐temporal origins. Location Tibetan Plateau and its surrounding regions. Time period Cenozoic. Major taxa studied Terrestrial vertebrates. Methods We used dispersal–extinction–cladogenesis models based on time‐calibrated phylogenies to reconstruct the ancestral ranges of 174 endemic TP species and compiled the ancestral ranges and age estimates of their dispersal events. We generated a possibility map of source areas for endemic TP species by counting the incidence of non‐TP sister clades in 110 km × 110 km grid cells. We used generalized linear mixed models to assess the relative importance of historical processes and environmental factors in explaining the geographical variations in the source areas. We created subsets based on four vertebrate classes to test whether the dispersal events varied spatially and temporally among taxonomic groups. Results We found that the endemic species colonized the TP as early as 55 Ma, and that the main colonization phase started to increase around 15 Ma and peaked after 6 Ma. The major source areas of endemic TP species include the Hengduan Mountains, the Himalayas, and Central Asia. Elevation difference had the strongest effect on the source areas, followed by geographical distance. The spatio‐temporal origins of species endemic to the TP and the potential drivers showed significant differences among vertebrate classes. Main conclusions Our study supports the hypothesis that endemic TP species originated from various zoogeographical regions at different times and highlights the important roles of the TP uplift and past climatic changes for determining the spatio‐temporal origins of endemic TP species.

Two new 8-isopentenyl isoflavane derivatives from Astragalus dolichochaete diels - Ding-Wei Wang; Chao-Jiang Xiao; Lin Qiu; Xin-Yan Tian; Xiang Dong; Bei Jiang (Natural Product Research, 2021)

Three new acenaphthene derivatives from rhizomes of Musa basjoo and their cytotoxic activity - Li Jiang; Bao Zhang; Yang Wang; Jia Sun; Xue Ma; Guangcheng Wang; Sihong Fu; Changhu Lin; YongJun Li (Natural Product Research, 2021)

The Effects of Installation on the Elastic Stiffness Coefficients of Spudcan Foundations - Wen-Long Lin; Zhen Wang; Fei Liu; Jiang-Tao Yi (Journal of Marine Science and Engineering, 2021)
Subjected to pre-load, spudcan foundations, widely utilized to support offshore jack-up rigs, may penetrate in a few diameters into soft clays before mobilizing sufficient resistance from soil. While its stress–strain behavior is known to be affected by the embedment condition and soil backflow, the small-strain calculation with wished-in-place assumption was previously adopted to analyze its elastic stiffness coefficients. This study takes advantage of a recently developed dual-stage Eulerian–Lagrangian (DSEL) technique to re-evaluate the elastic stiffness coefficients of spudcans after realistically modelling the deep, continuous spudcan penetration. A numerical parametric exercise is conducted to investigate the effects of strength non-homogeneity, embedment depths, and the spudcan’s size on the elastic stiffness. On these bases, an expression is provided such that the practicing engineers can conveniently factor the installation effects into the estimation of elastic stiffness coefficients of spudcans.

TLR8 in the Trigeminal Ganglion Contributes to the Maintenance of Trigeminal Neuropathic Pain in Mice - Lin-Xia Zhao; Ming Jiang; Xue-Qiang Bai; De-Li Cao; Xiao-Bo Wu; Jing Zhang; Jian-Shuang Guo; Tong-Tong Chen; Juan Wang; Hao Wu; Yong-Jing Gao; Zhi-Jun Zhang (Neuroscience Bulletin, 2021)
Trigeminal neuropathic pain (TNP) is a significant health problem but the involved mechanism has not been completely elucidated. Toll-like receptors (TLRs) have recently been demonstrated to be expressed in the dorsal root ganglion and involved in chronic pain. Here, we show that TLR8 was persistently increased in the trigeminal ganglion (TG) neurons in model of TNP induced by partial infraorbital nerve ligation (pIONL). In addition, deletion or knockdown of Tlr8 in the TG attenuated pIONL-induced mechanical allodynia, reduced the activation of ERK and p38-MAPK, and decreased the expression of pro-inflammatory cytokines in the TG. Furthermore, intra-TG injection of the TLR8 agonist VTX-2337 induced pain hypersensitivity. VTX-2337 also increased the intracellular Ca 2+ concentration, induced the activation of ERK and p38, and increased the expression of pro-inflammatory cytokines in the TG. These data indicate that TLR8 contributes to the maintenance of TNP through increasing MAPK-mediated neuroinflammation. Targeting TLR8 signaling may be effective for the treatment of TNP.

Maternal Separation-Induced Histone Acetylation Correlates with BDNF-Programmed Synaptic Changes in an Animal Model of PTSD with Sex Differences - Haoran Sun; Xianqiang Zhang; Yujia Kong; Luping Gou; Bo Lian; Yanyu Wang; Li Jiang; Qi Li; Hongwei Sun; Lin Sun (Molecular Neurobiology, 2021)

Orographic effects on the propagation and rainfall modification associated with the 2007–08 Madden–Julian oscillation (MJO) past the New Guinea Highlands - Yuh-Lang Lin; William Agyakwah; Justin G. Riley; Huang-Hsiung Hsu; Li-Chiang Jiang (Meteorology and Atmospheric Physics, 2021)

Calcium signalling mediated the regulation of growth and polysaccharide accumulation by light quality in Dendrobium officinale protocorms - Ting Lei; Suping Gao; Xiao Lin; Kaihui Zhang; Yingqi Liu; Wenji Li; Di Hu; Xiaofang Yu; Mingyan Jiang; Qibing Chen; Ying Sun (Horticulture, Environment, and Biotechnology, 2021)

Does technology advancement reduce aggregate carbon dioxide emissions? Evidence from 66 countries with panel threshold regression model - Ruzi Li; Lin Lin; Lei Jiang; Yaobin Liu; Chien-Chiang Lee (Environmental Science and Pollution Research, 2021)

Crenobacter intestini sp. nov., Isolated from the Intestinal Tract of Konosirus punctatus - Song-Biao Shi; Jia-Fa Wu; Li-Fang Yang; Ming-Guo Jiang; Cai-Mi Gao; Cheng-Lin Jiang; Yi Jiang (Current Microbiology, 2021)

Strategies to solve the reverse inference fallacy in future MRI studies of schizophrenia: a review - Chuanjun Zhuo; Gongying Li; Xiaodong Lin; Deguo Jiang; Yong Xu; Hongjun Tian; Wenqiang Wang; Xueqin Song (Brain Imaging and Behavior, 2021)
Few advances in schizophrenia research have been translated into clinical practice, despite 60 years of serum biomarkers studies and 50 years of genetic studies. During the last 30 years, neuroimaging studies on schizophrenia have gradually increased, partly due to the beautiful prospect that the pathophysiology of schizophrenia could be explained entirely by the Human Connectome Project (HCP). However, the fallacy of reverse inference has been a critical problem of the HCP. For this reason, there is a dire need for new strategies or research “bridges” to further schizophrenia at the biological level. To understand the importance of research “bridges,” it is vital to examine the strengths and weaknesses of the recent literature. Hence, in this review, our team has summarized the recent literature (1995–2018) about magnetic resonance imaging (MRI) of schizophrenia in terms of regional and global structural and functional alterations. We have also provided a new proposal that may supplement the HCP for studying schizophrenia. As postulated, despite the vast number of MRI studies in schizophrenia, the lack of homogeneity between the studies, along with the relatedness of schizophrenia with other neurological disorders, has hindered the study of schizophrenia. In addition, the reverse inference cannot be used to diagnose schizophrenia, further limiting the clinical impact of findings from medical imaging studies. We believe that multidisciplinary technologies may be used to develop research “bridges” to further investigate schizophrenia at the single neuron or neuron cluster levels. We have postulated about future strategies for overcoming the current limitations and establishing the research “bridges,” with an emphasis on multimodality imaging, molecular imaging, neuron cluster signals, single transmitter biomarkers, and nanotechnology. These research “bridges” may help solve the reverse inference fallacy and improve our understanding of schizophrenia for future studies.

Abberant inverted U-shaped brain pattern and trait-related retinal impairment in schizophrenia patients with combined auditory and visual hallucinations: a pilot study - Chuanjun Zhuo; Bo Xiao; Ce Chen; Deguo Jiang; Gongying Li; Xiaoyan Ma; Ranli Li; Lina Wang; Yong Xu; Chunhua Zhou; Xiaodong Lin (Brain Imaging and Behavior, 2021)
Schizophrenic patients often experience auditory hallucinations (AHs) and visual hallucinations (VHs). However, brain and retinal alterations associated with combined AHs and VHs in schizophrenic patients are unknown. This study aimed o investigate brain and retinal alterations in first episode un-treated schizophrenic patients with combined AHs and VHs (FUSCHAV). FUSCHAV patients ( n = 120), divided into four groups according to severity of AH and VH symptoms, were compared to healthy controls ( n = 30). Gray matter volume (GMV) and global functional connectivity density (gFCD) were recorded to reflect brain structure and functional alterations. Total retinal thickness was acquired by optical coherence tomography to assess retinal impairment. The majority of FUSCHAV patients (85.8%) demonstrated both GMV reduction and gFCD increases along with retinal thinning compared to healthy controls. The severity of GMV reduction and gFCD increase differed between patient groups, ranked from highest to lowest severity as follows: severe AHs combined with severe VHs (FUSCHSASV, 20 patients), moderate AHs combined with severe VHs (FUSCHMASV, 23 patients), severe AHs combined with moderate VHs (FUSCHSAMV, 28 patients), and moderate AHs combined with moderate VHs (FUSCHMAMV, 26). Retinal impairment was similar among the four FUSCHAV groups. GMV reduction and gFCD increases in the frontal-parietal lobule show an inverted U-shaped pattern among FUSCHAV patients according to AH and VH severity, while retinal impairment remains stable among FUSCHAV groups. These findings indicate a reciprocal deterioration in auditory and visual disturbances among FUSCHAV patients.

Control System Design and Implementation at Flexible, Distributed Offshore Sensor Test Sites in the Yangtze Estuary Area - Qingsong Hu; Chao Jiang; Lin Du; Jun Li; Leilei Chen; Peng Xiang; Hongcheng Zhang; Hafiz Abd ur Rahman (Journal of Ocean University of China, 2021)

miR-23b Attenuates LPS-Induced Inflammatory Responses in Acute Lung Injury via Inhibition of HDAC2 - Zhi-Feng Luo; Xiang-Hui Jiang; Huan Liu; Li-Yuan He; Xiong Luo; Fu-Chun Chen; Yu-Lin Tan (Biochemical Genetics, 2021)

Re-use of wasted sludge to treat industrial pollutants - Ru Wang; Li-ping Yu; Bibi Saima Zeb; Lin-jie Yuan; Meng-yu Liu; Lin-jiang Yuan (Water, Air, & Soil Pollution, 2021)

Spatial patterns of phytoplankton community and biomass along the Kuroshio Extension and adjacent waters in late spring - Yu Wang; Jianhua Kang; Xiuwu Sun; Jiang Huang; Yili Lin; Peng Xiang (Marine Biology, 2021)

Kidney function change after transcatheter aortic valve replacement in patients with diabetes and/or hypertension - Jiaqi Fan; Changjie Yu; Kaida Ren; Wanbing Lin; Stella Ng; Zexin Chen; Xinping Lin; Lihan Wang; Qifeng Zhu; Yuxin He; Jubo Jiang; Xianbao Liu; et al. (Journal of Zhejiang University-SCIENCE B, 2021)

Upregulation of long noncoding RNA XIST has anticancer effects on ovarian cancer through sponging miR-106a - Ting Guo; Donglan Yuan; Wei Zhang; Dandan Zhu; Aifang Xiao; Guangyao Mao; Wenjuan Jiang; Mei Lin; Jun Wang (Human Cell, 2021)

Delayed association of acute particulate matter 2.5 air pollution exposure with loss of complexity in cardiac rhythm dynamics: insight from detrended fluctuation analysis - Tsung-Ying Tsai; Li-Wei Lo; Shin-Huei Liu; Wen-Han Cheng; Yu-Hui Chou; Wei-Lun Lin; Yenn-Jiang Lin; Shih-Lin Chang; Yu-Feng Hu; Fa-Po Chung; Jo-Nan Liao; Tze-Fan Chao; et al. (Environmental Science and Pollution Research, 2021)

Effects of Grazing, Wind Erosion, and Dust Deposition on Plant Community Composition and Structure in a Temperate Steppe - Mengmei Zheng; Jian Song; Jingyi Ru; Zhenxing Zhou; Mingxing Zhong; Lin Jiang; Dafeng Hui; Shiqiang Wan (Ecosystems, 2021)

Lentibacillus saliphilus. sp. nov., a moderately halophilic bacterium isolated from a saltern in Korea - Yun Wang; Gang-Qiang Jiang; Hong-Ping Lin; Peng Sun; Hong-Yan Zhang; Dong-Mei Lu; Li-Yun Wang; Chang-Jin Kim; Shu-Kun Tang (Archives of Microbiology, 2021)

Warming Iron-Limited Oceans Enhance Nitrogen Fixation and Drive Biogeographic Specialization of the Globally Important Cyanobacterium Crocosphaera - Nina Yang; Carlin A. Merkel; Yu-An Lin; Naomi M. Levine; Nicholas J. Hawco; Hai-Bo Jiang; Ping-Ping Qu; Michelle A. DeMers; Eric A. Webb; Fei-Xue Fu; David A. Hutchins (Frontiers in Marine Science, 2021)
Primary productivity in the nutrient-poor subtropical ocean gyres depends on new nitrogen inputs from nitrogen fixers that convert inert dinitrogen gas into bioavailable forms. Temperature and iron (Fe) availability constrain marine nitrogen fixation, and both are changing due to anthropogenic ocean warming. We examined the physiological responses of the globally important marine nitrogen fixer, Crocosphaera watsonii across its full thermal range as a function of iron availability. At the lower end of its thermal range, from 22 to 27°C, Crocosphaera growth, nitrogen fixation, and Nitrogen-specific Iron Use Efficiencies (N-IUEs, mol N fixed hour –1 mol Fe –1 ) increased with temperature. At an optimal growth temperature of 27°C, N-IUEs were 66% higher under iron-limited conditions than iron-replete conditions, indicating that low-iron availability increases metabolic efficiency. However, Crocosphaera growth and function decrease from 27 to 32°C, temperatures that are predicted for an increasing fraction of tropical oceans in the future. Altogether, this suggests that Crocosphaera are well adapted to iron-limited, warm waters, within prescribed limits. A model incorporating these results under the IPCC RCP 8.5 warming scenario predicts that Crocosphaera N-IUEs could increase by a net 47% by 2100, particularly in higher-latitude waters. These results contrast with published responses of another dominant nitrogen fixer ( Trichodesmium ), with predicted N-IUEs that increase most in low-latitude, tropical waters. These models project that differing responses of Crocosphaera and Trichodesmium N-IUEs to future warming of iron-limited oceans could enhance their current contributions to global marine nitrogen fixation with rates increasing by ∼91 and ∼22%, respectively, thereby shifting their relative importance to marine new production and also intensifying their regional divergence. Thus, interactive temperature and iron effects may profoundly transform existing paradigms of nitrogen biogeochemistry and primary productivity in open ocean regimes.

Evaluation of favourable hot dry rock areas in the east of the Yishu fault zone in China - Q. Deng; A. Jiang; Z. Tong; H. Lin; Z. Gao; X. Sun; M. Nie (Australian Journal of Earth Sciences, 2021)

Two new phthalide derivatives from the endophytic fungus Penicillium vulpinum isolated from Sophora tonkinensis - Yuyue Qin; Xiaobo Liu; Jing Lin; Jingying Huang; Xiaofei Jiang; Tuxiang Mo; Zhaolong Xu; Jun Li; Ruiyun Yang (Natural Product Research, 2021)

Roles of FERONIA-like receptor genes in regulating grain size and quality in rice - Long Wang; Dandan Wang; Zhuhong Yang; Shun Jiang; Jianing Qu; Wei He; Zhenming Liu; Junjie Xing; Youchu Ma; Qinlu Lin; Feng Yu (Science China Life Sciences, 2021)

MicroRNA-1246 regulates proliferation, invasion, and differentiation in human vascular smooth muscle cells by targeting cystic fibrosis transmembrane conductance regulator (CFTR) - Diguang Pan; Guiyong Liu; Bin Li; Jingbo Jiang; Wei Chen; Wei Li; Lin Zhang; Yubao Hu; Shuyun Xie; Huayun Yang (Pflügers Archiv - European Journal of Physiology, 2021)

Evaluation of geogenic cadmium bioavailability in soil-rice system with high geochemical background caused by black shales - Cong Zhong; Zixu Feng; Wei Jiang; Lin Xiao; Xinying Zhang; Yinjun Zhao; Qing Lin (Journal of Soils and Sediments, 2021)

Inhibitory effects of novel 1,4-disubstituted 1,2,3-triazole compounds on quorum-sensing of P. aeruginosa PAO1 - Shuang Li; Yumin Zhang; Kai Jiang; Huiying Wang; Feng Lin (European Journal of Clinical Microbiology & Infectious Diseases, 2021)

Injection route affects intra-articular hyaluronic acid distribution and clinical outcome in viscosupplementation treatment for knee osteoarthritis: a combined cadaver study and randomized clinical trial - Jun Xiao; Yong Hu; Lin Huang; Zhi-Fa Huang; Wei-Zhou Jiang; Yu-Qiang Luo; Meng-Yan Jia; Di Chen; Zhan-Jun Shi (Drug Delivery and Translational Research, 2021)

Paracoccus lichenicola sp. nov., Isolated from Lichen - Lei Lang; De-Feng An; Long-Qian Jiang; Gui-Ding Li; Li-Song Wang; Xin-Yu Wang; Qin-Yuan Li; Cheng-Lin Jiang; Yi Jiang (Current Microbiology, 2021)

Association of Circulating and Aortic Zinc and Copper Levels with Clinical Abdominal Aortic Aneurysm: a Meta-analysis - Tingting Chen; Hongliang Zhang; Yang Zhang; Mengqi Yang; Juntao Wu; Minjun Yang; Jiangbo Lin; Weixu Gao; Lijiang Tang; Baohui Xu; Jianjun Jiang; Xiaofeng Chen (Biological Trace Element Research, 2021)

Structural analysis of glycosaminoglycans from Oviductus ranae - Haiyue Huang; Jin Mao; Quntao Liang; Jianghui Lin; Lilong Jiang; Shutao Liu; Joshua S. Sharp; Zheng Wei (Glycoconjugate Journal, 2021)

Clinical application of pyrrole–hemoglobin adducts as a biomarker of pyrrolizidine alkaloid exposure in humans - Jiang Ma; Wei Zhang; Yisheng He; Lin Zhu; Chunyuan Zhang; Jia Liu; Yang Ye; Yuzheng Zhuge; Ge Lin (Archives of Toxicology, 2021)

A drug-tunable Flt23k gene therapy for controlled intervention in retinal neovascularization - Jinying Chen; Fan-Li Lin; Jacqueline Y. K. Leung; Leilei Tu; Jiang-Hui Wang; Yu-Fan Chuang; Fan Li; Hsin-Hui Shen; Gregory J. Dusting; Vickie H. Y. Wong; Leszek Lisowski; Alex W. Hewitt; et al. (Angiogenesis, 2021)

Two new physalin derivatives from Physalis alkekengi L. var. franchetii (Mast.) Makino - Jian-Lu Sun; Yong-Jun Jiang; Lin Cheng (Natural Product Research, 2021)

Syn-2, 3-diols and anti-inflammatory indole derivatives from Streptomyces sp. CB09001 - Lin Jiang; Hong Pu; Xiangjing Qin; Jianxin Liu; Zhongqing Wen; Yimin Huang; Jingxi Xiang; Yunxi Xiang; Jianhua Ju; Yanwen Duan; Yong Huang (Natural Product Research, 2021)

Comparison of the Nutritional Quality of Three Edible Tissues from Precocious and Normal Adult Female Chinese Mitten Crabs ( Eriocheir sinensis ) - Huafeng Cheng; Haoran Wu; Feng Liang; Mengtian Ge; Shaotong Jiang; Lin Lin; Jianfeng Lu (Journal of Aquatic Food Product Technology, 2021)

Understanding the dynamical-microphysical-electrical processes associated with severe thunderstorms over the Beijing metropolitan region - Xiushu Qie; Shanfeng Yuan; Zhixiong Chen; Dongfang Wang; Dongxia Liu; Mengyu Sun; Zhuling Sun; Abhay Srivastava; Hongbo Zhang; Jingyu Lu; Hui Xiao; Yongheng Bi; et al. (Science China Earth Sciences, 2021)

Method for fast staining and obtaining high-magnification and high-resolution cell images of Nicotiana benthamiana - Yuanyuan Jiang; Jiangrong Peng; Yunpeng Cao; Zhiqiang Han; Ling Zhang; Wenbing Su; Shunquan Lin; Yuan Yuan; Bin Wang; Xianghui Yang; Zhike Zhang (Physiology and Molecular Biology of Plants, 2021)

Identification of 5S and 45S rDNA sites in Chrysanthemum species by using oligonucleotide fluorescence in situ hybridization (Oligo-FISH) - Jun He; Sisi Lin; Zhongyu Yu; Aiping Song; Zhiyong Guan; Weimin Fang; Sumei Chen; Fei Zhang; Jiafu Jiang; Fadi Chen; Haibin Wang (Molecular Biology Reports, 2021)

Memory impairment of chewing-side preference mice is associated with 5-HT-BDNF signal pathway - Hua Jiang; Hong Yin; Lin Wang; Chunzhen Feng; Yang Bai; Dongzong Huang; Qiao Zhang; Hongchen Liu; Yuan Hu (Molecular and Cellular Biochemistry, 2021)

Circular RNA has_circ_0000034 accelerates retinoblastoma advancement through the miR-361-3p/ADAM19 axis - Yanhua Jiang; Fan Xiao; Lin Wang; Ting Wang; Linlin Chen (Molecular and Cellular Biochemistry, 2021)

Influence of the Micro-deformation Characteristics of Binary Media on the Shear Behavior of Structural Plane - Hang Lin; Lu Han; Yixian Wang; Rihong Cao; Yanlin Zhao; Chong Jiang (Geotechnical and Geological Engineering, 2021)

KASP markers to detect sub-chromosomal arm translocations between 6VS of Haynaldia villosa and 6AS of wheat - Shujie Zhang; Chaolan Fan; Jiangtao Luo; Lei Huang; Die Xie; Yazhou Li; Zhuo Chen; Bo Jiang; Shunzong Ning; Zhongwei Yuan; Lin Huang; Lianquan Zhang; et al. (Euphytica, 2021)

Biochar improves heavy metal passivation during wet anaerobic digestion of pig manure - Jun Wang; Xiaoxia Hao; Zile Liu; Zili Guo; Li Zhu; Bangjie Xiong; Dongmei Jiang; Linyuan Shen; Mingzhou Li; Bo Kang; Guoqing Tang; Lin Bai (Environmental Science and Pollution Research, 2021)

Lung injury induced by pyrrolizidine alkaloids depends on metabolism by hepatic cytochrome P450s and blood transport of reactive metabolites - Yisheng He; Wei Lian; Liang Ding; Xiaoyu Fan; Jiang Ma; Qing-Yu Zhang; Xinxin Ding; Ge Lin (Archives of Toxicology, 2021)

Hydrothermal dolomitization in the Middle Permian in the Central Sichuan Basin, SW China: evidence from petrology, geochemistry, and fluid inclusions - Lin Qi; Yifan Gu; Puwei He; Zhanlei Wang; Yuqiang Jiang; Shun Li; Yadong Zhou (Arabian Journal of Geosciences, 2021)

Influence of the Eastern Pacific and Central Pacific Types of ENSO on the South Asian Summer Monsoon - Fangxing Fan; Renping Lin; Xianghui Fang; Feng Xue; Fei Zheng; Jiang Zhu (Advances in Atmospheric Sciences, 2021)

Tree ring width‐based January–March mean minimum temperature reconstruction from Larix gmelinii in the Greater Khingan Mountains, China since AD 1765 - Yangao Jiang; Chuan Liu; Junhui Zhang; Shijie Han; Cassius E. O. Coombs; Xiaoguang Wang; Junwei Wang; Lin Hao; Shengzhong Dong (International Journal of Climatology, 2021)
A ring‐width chronology of Larix gmelinii (LG) was developed in the northern Greater Khingan Mountains region of China. The response function analyses revealed that the local mean minimum temperature of January–March ( T 1–3 ) was the most limiting factor affecting the radial growth of LG trees. Based on correlation analysis, a reconstructed T 1–3 series from 1765 to 2013 was produced using standard ring‐width chronology. The reconstruction explained 41.2% of the total variance in recorded monthly mean minimum temperatures from 1960 to 2013. The reconstructed T 1–3 series had similar variability when compared with the May–September mean temperature reconstruction in Inner Mongolia (IM) and the February–March mean minimum temperature reconstruction in Yichun (YC). This reconstructed T 1–3 series also captured the severe snow disaster and cold wave events recorded from historical documents in Heilongjiang and Inner Mongolia. Spatial correlations between reconstructed series and gridded temperature data also provided a high level of confidence. In addition, significant relationships between the reconstructed T 1–3 series and the Pacific Decadal Oscillation (PDO), El Niño–Southern Oscillation (ENSO), North Atlantic Oscillation (NAO), solar activity, indicated that the T 1–3 variation might be influenced by large‐scale ocean–atmosphere interactions.

Novel Contributions to the Taxonomy of the Ciliates Genus Euplotes (Ciliophora, Euplotida): Redescription of Two Poorly Known Species, With a Brief Note on the Distributions of This Genus in Coastal Waters of Southern China - Weiwei Liu; Jiamei Jiang; Yehui Tan; Xiaofeng Lin (Frontiers in Marine Science, 2020)
As the typical periphytic ciliate, the genus Euplotes Ehrenberg, 1830 is highly diversified and commonly observed in marine water. In this study, the living morphology, infraciliature and silverline system of two poorly known Euplotes species, E. neapolitanus Wichterman, 1964 and E. antarcticus Fenchel and Lee, 1972 , isolated from coastal water of southern China, were investigated. The original description of these two species were brief, and thus we provided detailed redescription based on our Chinese population. Their diagnoses were improved by adding some morphology characteristics and their detailed illustrations and photomicrographs were first supplied here. Based on the sufficient justification for identification of our population by morphology, their small subunit ribosomal RNA gene sequences which have been reported were linked to the accurate species name. Phylogenetic analyses showed that these two species cluster with their congeners which shared high morphological similarities with them. In addition, the geographic distribution of the genus Euplotes in coast of southern China was revealed, and the mangrove was considered as the ideal habitat for them by possessing the higher species richness.

Heterosis-associated genes confer high yield in super hybrid rice - Tianzi Lin; Cong Zhou; Gaoming Chen; Jun Yu; Wei Wu; Yuwei Ge; Xiaolan Liu; Jin Li; Xingzhou Jiang; Weijie Tang; Yunlu Tian; Zhigang Zhao; et al. (Theoretical and Applied Genetics, 2020)
Key message Heterosis QTLs, including qSS7 and qHD8, with dominance effects were identified through GBS and large-scale phenotyping of CSSLs and hybrid F 1 populations in a paddy field. Abstract Heterosis has contributed immensely to agricultural production, but its genetic basis is unclear. We evaluated dominance effects by creating two hybrid populations: a B-homo set with a homozygous background and heterozygous chromosomal segments and a B-heter set with a heterozygous background and homozygous segments. This was achieved by crossing a set of 156 backcrossed-derived chromosome segment substitution lines (CSSLs) with their recurrent parent (9311), the male parent of the first super-high-yield hybrid Liangyoupei9 (LYP9), and with the female parent (PA64s) of the hybrid. The CSSLs were subjected to a genotyping-by-sequencing analysis to develop a genetic map of segments introduced from the PA64s. We evaluated the heterotic effects on eight yield-related traits in the hybrid variety and F 1 populations in large-scale field experiments over 2 years. Using a linkage map consisting of high-density SNPs, we identified heterosis-associated genes in LYP9. Five candidate genes contributed to the high yield of LYP9, with qSS7 and qHD8 repeatedly detected in both B-hybrid populations. The heterozygous segments harboring qSS7 and qHD8 showed dominance effects that contributed to the heterosis of yield components in the hybrid rice variety Liangyoupei9.

Contribution of Val/Ile87 residue in the extracellular domain in agonist-induced current responses of the human and rat P2X7 receptors - Emily A Caseley; Stephen P Muench; Lin-Hua Jiang (Purinergic Signalling, 2020)
The P2X7 receptor (P2X7R) is an ATP-gated cation channel with a critical role in many physiological and pathological processes, and shows prominent functional differences across mammalian species, exemplified by larger current responses of the rat (r) P2X7R to ATP and its analogue BzATP and a greater sensitivity to agonists compared with the human (h) P2X7R. Here, we showed that substitution of Val87 residue in the extracellular domain of the hP2X7R with isoleucine in the rP2X7R increased the current responses of the hP2X7R to both ATP and BzATP. Conversely, introduction of reciprocal I87V mutation in the rP2X7R led to a noticeable but statistically insignificant reduction in the current responses of the rP2X7R to ATP and BzATP. The mutations did not affect the sensitivity of the human and rat P2X7Rs to ATP and BzATP. These results suggest a contribution of Val/Ile87 in agonist-induced current responses of human and rat P2X7Rs, which helps to better understand the molecular determinants for species-dependent function of the mammalian P2X7Rs.

Magnesium biofortification of Italian ryegrass (Lolium multiflorum L.) via agronomy and breeding as a potential way to reduce grass tetany in grazing ruminants - Diriba B. Kumssa; J. Alan Lovatt; Neil S. Graham; Sarah Palmer; Rory Hayden; Lolita Wilson; Scott D. Young; R. Murray Lark; Beth Penrose; E. Louise Ander; Russell Thompson; Lin-Xi Jiang; et al. (Plant and Soil, 2020)
Aim Magnesium (Mg) deficiency (known as grass tetany) is a serious metabolic disorder that affects grazing ruminants. We tested whether Mg-fertiliser can increase Mg concentration of Italian ryegrasses ( Lolium multiflorum L.) including a cultivar (cv. Bb2067; ‘Magnet’), bred to accumulate larger concentrations of Mg. Methods Under controlled environment (CE) conditions, three cultivars (cv. Bb2067, cv. Bb2068, cv. RvP) were grown in low-nutrient compost at six fertiliser rates (0–1500 μM MgCl 2 .6H 2 O). Under field conditions, the three cultivars in the CE condition and cv. Alamo were grown at two sites, and four rates of MgSO 4 fertiliser application rates (0–200 kg ha −1 MgO). Multiple grass cuts were taken over two-years. Results Grass Mg concentration increased with increasing Mg-fertiliser application rates in all cultivars and conditions. Under field conditions, cv. Bb2067 had 11–73% greater grass Mg concentration and smaller forage tetany index (FTI) than other cultivars across the Mg-fertiliser application rates, sites and cuts. Grass dry matter (DM) yield of cv. Bb2067 was significantly ( p < 0.05) smaller than cv. Alamo. The effect of Mg-fertiliser rate on DM yield was not significant ( p ≥ 0.05). Conclusions Biofortification of grass with Mg through breeding and agronomy can improve the forage Mg concentration for grazing ruminants, even in high-growth spring grass conditions when hypomagnesaemia is most prevalent. Response to agronomic biofortification varied with cultivar, Mg-fertiliser rate, site and weather. The cost:benefit of these approaches and farmer acceptability, and the impact on cattle and sheep grazing on grasses biofortified with Mg requires further investigation.

Cold water anomalies in the middle layer of the northern Taiwan Strait in spring—a numerical approach - Zhonghua Zhao; Jianwei Lin; Jun Fu; Yuwu Jiang (Ocean Dynamics, 2020)

Long non-coding RNA LINC00460 promotes proliferation and inhibits apoptosis of cervical cancer cells by targeting microRNA-503-5p - Lin Lin; Bing Xin; Tao Jiang; Xin-lu Wang; Hua Yang; Tie-mei Shi (Molecular and Cellular Biochemistry, 2020)

Hepato-protective effect of fucoidan extracted from acid-processed Sargassum fusiformis in ethanol-treated Chang liver cells and in a zebrafish model - Yu-Lin Dai; Yun-Fei Jiang; Yu-Hang Nie; Yu-An Lu; Min-Cheol Kang; You-Jin Jeon (Journal of Applied Phycology, 2020)

Management of Gout-associated MSU crystals-induced NLRP3 inflammasome activation by procyanidin B2: targeting IL-1β and Cathepsin B in macrophages - Chun-Ying Qiao; Ying Li; Yue Shang; Min Jiang; Jian Liu; Zi-Ying Zhan; Huan Ye; Yong-Ce Lin; Jing-Ya Jiao; Rong-Hui Sun; Zhi-Hong Zhang; Mei-Hua Piao; et al. (Inflammopharmacology, 2020)

Deep-Learning-Based Segmentation and Localization of White Matter Hyperintensities on Magnetic Resonance Images - Wenhao Jiang; Fengyu Lin; Jian Zhang; Taowei Zhan; Peng Cao; Silun Wang (Interdisciplinary Sciences: Computational Life Sciences, 2020)

Association of in-hospital intensive statins dosage and death in arteriosclerotic cardiovascular disease with percutaneous coronary intervention: insights of multicentre cohort from China - Peng-yuan Chen; Yuan-hui Liu; Chong-yang Duan; Hua-lin Fan; Li-huan Zeng; Wei Guo; Lei Jiang; Xue-biao Wei; Wen-fei He; Sha Tao; Zhi-qiang Guo; Ji-yan Chen; et al. (European Journal of Clinical Pharmacology, 2020)

Gut dysbiosis-influence on amygdala-based functional activity in patients with end stage renal disease: a preliminary study - Li Juan Zheng; Li Lin; Jianhui Zhong; Zhihong Zhang; Yu Bing Ye; Xin Yuan Zhang; Yun Fei Wang; Han Zhang; Ya Liu; Guang Ming Lu; Dehua Gong; Long Jiang Zhang (Brain Imaging and Behavior, 2020)

Cortical 3-hinges could serve as hubs in cortico-cortical connective network - Tuo Zhang; Xiao Li; Xi Jiang; Fangfei Ge; Shu Zhang; Lin Zhao; Huan Liu; Ying Huang; Xianqiao Wang; Jian Yang; Lei Guo; Xiaoping Hu; et al. (Brain Imaging and Behavior, 2020)
Mapping the relation between cortical convolution and structural/functional brain architectures could provide deep insights into the mechanisms of brain development, evolution and diseases. In our previous studies, we found a unique gyral folding pattern, termed a 3-hinge, which was defined as the conjunction of three gyral crests. The uniqueness of the 3-hinge was evidenced by its thicker cortex and stronger fiber connections than other gyral regions. However, the role that 3-hinges play in cortico-cortical connective architecture remains unclear. To this end, we conducted MRI studies by constructing structural cortico-cortical connective networks based on a fine-granular cortical parcellation, the parcels of which were automatically labeled as 3-hinge, 2-hinge (ordinary gyrus) or sulcus. On human brains, 3-hinges possess significantly higher degrees, strengths and betweennesses than 2-hinges, suggesting that 3-hinges could serve more like hubs in the cortico-cortical connective network. This hypothesis gains supports from human functional network analyses, in which 3-hinges are involved in more global functional networks than ordinary gyri. In addition, 3-hinges could serve as ‘connector’ hubs rather than ‘provincial’ hubs and they account for a dominant proportion of nodes in the high-level ‘backbone’ of the network. These structural results are reproduced on chimpanzee and macaque brains, while the roles of 3-hinges as hubs become more pronounced in higher order primates. Our new findings could provide a new window to the relation between cortical convolution, anatomical connection and brain function.

Differences in functional connectivity density among subtypes of schizophrenic auditory hallucination - Chuanjun Zhuo; Gongying Li; Feng Ji; Ce Chen; Deguo Jiang; Xiaodong Lin; Yong Xu; Hongjun Tian; Lina Wang; Chunhua Zhou; Xiao Lin (Brain Imaging and Behavior, 2020)

Sand barrier morphological evolution based on time series remote sensing images: a case study of Anhaiao, Pingtan - Heshan Lin; Xingguang Yu; Zhigang Yu; Yikang Gao; Jinyan Xu; Aiping Feng; Zhijun Liu; Degang Jiang; Fan Yu (Acta Oceanologica Sinica, 2020)

Endoplasmic reticulum‐associated degradation mediated by MoHrd1 and MoDer1 is pivotal for appressorium development and pathogenicity of Magnaporthe oryzae - Wei Tang; Haolang Jiang; Osakina Aron; Min Wang; Xueyu Wang; Jiangfeng Chen; Birong Lin; Xuehang Chen; Qiaojia Zheng; Xiuqin Gao; Dou He; Airong Wang; et al. (Environmental Microbiology, 2020)
Summary Most secretory proteins are folded and modified in the endoplasmic reticulum (ER); however, protein folding is error‐prone, resulting in toxic protein aggregation and cause ER stress. Irreversibly misfolded proteins are subjected to ER‐associated degradation (ERAD), modified by ubiquitination, and degraded by the 26S proteasome. The yeast ERAD ubiquitin ligase Hrd1p and multispanning membrane protein Der1p are involved in ubiquitination and transportation of the folding‐defective proteins. Here, we performed functional characterization of MoHrd1 and MoDer1 and revealed that both of them are localized to the ER and are pivotal for ERAD substrate degradation and the ER stress response. MoHrd1 and MoDer1 are involved in hyphal growth, asexual reproduction, infection‐related morphogenesis, protein secretion and pathogenicity of M. oryzae . Importantly, MoHrd1 and MoDer1 mediated conidial autophagic cell death and subsequent septin ring assembly at the appressorium pore, leading to abnormal appressorium development and loss of pathogenicity. In addition, deletion of MoHrd1 and MoDer1 activated the basal unfolded protein response (UPR) and autophagy, suggesting that crosstalk between ERAD and two other closely related mechanisms in ER quality control system (UPR and autophagy) governs the ER stress response. Our study indicates the importance of ERAD function in fungal development and pathogenesis of M. oryzae .

FW0622, a new siderophore isolated from marine Verrucosispora sp. by genomic mining - Wei Zhao; Fei Peng; Chuan-xi Wang; Yang Xie; Ru Lin; Zhi-kai Fang; Fei Sun; Yun-yang Lian; Hong Jiang (Natural Product Research, 2020)

Effects of Plant Diversity and Plant Density on Ecosystem Functions in Floating Constructed Wetlands - Wenjuan Han; Xiaoling Sheng; Jiongni Shao; Jia Jiang; Qinru He; Ying Lin (Water, Air, & Soil Pollution, 2020)

Divergence in flowering time is a major component contributing to reproductive isolation between two wild rice species (Oryza rufipogon and O. nivara) - Xun Xu; Qing-Lin Meng; Mu-Fan Geng; Ning-Ning Ren; Lian Zhou; Yu-Su Du; Zhe Cai; Mei-Xia Wang; Xin Wang; Xiu-Hua Wang; Jing-Dan Han; Shuai Jiang; et al. (Science China Life Sciences, 2020)

Small grain and semi-dwarf 3, a WRKY transcription factor, negatively regulates plant height and grain size by stabilizing SLR1 expression in rice - Jie Lan; Qibing Lin; Chunlei Zhou; Yakun Ren; Xi Liu; Rong Miao; Ruonan Jing; Changling Mou; Thanhliem Nguyen; Xingjie Zhu; Qian Wang; Xin Zhang; et al. (Plant Molecular Biology, 2020)

Two new species of Hortiboletus (Boletaceae, Boletales) from China - Hui-Jing Xie; Wen-Fei Lin; Shuai Jiang; Rou Xue; Lu-Ling Wu; Yu-Zhuo Zhang; Zhi-Qun Liang; Nian-Kai Zeng; Ming-Sheng Su (Mycological Progress, 2020)

Assessing the effects of oyster/kelp weight ratio on water column properties: an experimental IMTA study at Sanggou Bay, China - Jinghui Fang; Jianguang Fang; Qionglin Chen; Yuze Mao; Zengjie Jiang; Meirong Du; Yaping Gao; Fan Lin (Journal of Oceanology and Limnology, 2020)

Quantitative Assessment of Hippocampal Tau Pathology in AD and PART - Lei Zhang; Yankai Jiang; Jie Zhu; Huazheng Liang; Xiangyang He; Jiahong Qian; Hai Lin; Yubo Tao; Keqing Zhu (Journal of Molecular Neuroscience, 2020)
To quantitatively assess the distribution pattern of hippocampal tau pathology in Alzheimer’s disease (AD) and primary age-related tauopathy (PART), we investigated the distribution of phosphorylated tau protein (AT8) in 6 anatomically defined subregions of the hippocampal formation and developed a mathematical algorithm to compare the patterns of tau deposition in PART and AD. We demonstrated regional patterns of selective vulnerability as distinguishing features of PART and AD in functionally relevant structures of the hippocampus. In AD cases, tau pathology was high in both CA1 and subiculum, followed by CA2/3, entorhinal cortex (EC), CA4, and dentate gyrus (DG). In PART, the severity of tau pathology in CA1 and subiculum was high, followed by EC, CA2/3, CA4, and DG. There are significant differences between sector DG and CA1, DG and subiculum in both AD and PART.

Whether the carbon emission from green roofs can be effectively mitigated by recycling waste building material as green roof substrate during five-year operation? - Liangqian Fan; Jingting Wang; Xiaoling Liu; Hongbing Luo; Ke Zhang; Xiaoying Fu; Mei Li; Xiaoting Li; Bing Jiang; Jia Chen; Shuzhi Fu; You Mo; et al. (Environmental Science and Pollution Research, 2020)

Erratum to: An Examination of the Predictability of Tropical Cyclone Genesis in High-Resolution Coupled Models with Dynamically Downscaled Coupled Data Assimilation Initialization - Mingkui Li; Shaoqing Zhang; Lixin Wu; Xiaopei Lin; Ping Chang; Gohkan Danabasoglu; Zhiqiang Wei; Xiaolin Yu; Huiqin Hu; Xiaohui Ma; Weiwei Ma; Haoran Zhao; et al. (Advances in Atmospheric Sciences, 2020)

MicroRNA-107 Ameliorates Damage in a Cell Model of Alzheimer’s Disease by Mediating the FGF7/FGFR2/PI3K/Akt Pathway - Wei Chen; Lin Wu; Yueqiang Hu; Lingfei Jiang; Ni Liang; Jing Chen; Hongling Qin; Nong Tang (Journal of Molecular Neuroscience, 2020)

Effect of dietary isoleucine on skin mucus barrier and epithelial physical barrier functions of hybrid bagrid catfish Pelteobagrus vachelli × Leiocassis longirostris - Long Yin; Ye Zhao; Xiao-Qiu Zhou; Chao Yang; Lin Feng; Yang Liu; Wei-Dan Jiang; Pei Wu; Jian Zhou; Juan Zhao; Jun Jiang (Fish Physiology and Biochemistry, 2020)

Identification of Cyt2Ba from a New Strain of Bacillus thuringiensis and Its Toxicity in Bradysia difformis - Fan-Fan Wang; Shao-Xuan Qu; Jin-Sheng Lin; Hui-Ping Li; Li-Juan Hou; Ning Jiang; Xin Luo; Lin Ma (Current Microbiology, 2020)
Bradysia difformis is one of the most damaging pests in mushroom production in China. In this study, eight Bacillus thuringiensis strains were analyzed for insecticidal activity in B. difformis . The strain JW-1 showed the highest insecticidal activity against B. difformis larvae, but did not inhibit the mycelial growth of Pleurotus ostreatus and P. geesteranus . The 16S rRNA gene (1397 bp) and cyt2 gene (792 bp) were obtained from strain JW-1. The phylogenetic tree based on 16S rRNA gene and Cyt2 toxin showed that strain JW-1 was a member of B. thuringiensis and Cyt2 toxin belonged to Cyt2Ba toxin cluster. The Cyt2Ba toxin from strain JW-1 was overexpressed in E. coli as a fusion protein and the fusion protein (70 kDa) was purified by Ni-IDA affinity chromatography. The purified Cyt2Ba fusion protein was toxic to B. difformis larvae (LC 50 was 2.25 ng/mL). The identification of Cyt2Ba from strain JW-1 and confirmation of the insecticidal activity of Cyt2Ba in B. difformis provided a new means of biological control of the important pest in mushroom production.

Cloning and Characterization of a Ginsenoside-Hydrolyzing α-L-Arabinofuranosidase, CaAraf51, From Cellulosimicrobium aquatile Lyp51 - Sha-Sha Zuo; Yu-Chen Wang; Ling Zhu; Jiang-Yuan Zhao; Ming-Gang Li; Xiu-Lin Han; Meng-Liang Wen (Current Microbiology, 2020)

Complete Genome Sequences of Leclercia sp. W6 and W17 Isolated from a Gastric Cancer Patient - Yun-Yun Xu; Chao-Jie Huang; Lin Xu; Xia-Wei Jiang; Xue-Wei Xu; Xiao-Wu Xu (Current Microbiology, 2020)

Sodium Para-aminosalicylic Acid Reverses Changes of Glutamate Turnover in Manganese-Exposed Rats - Zhao-Cong Li; Fang Wang; Shao-Jun Li; Lin Zhao; Jun-Yan Li; Yue Deng; Xiao-Juan Zhu; Yu-Wen Zhang; Dong-Jie Peng; Yue-Ming Jiang (Biological Trace Element Research, 2020)

Epidemiological and phylogenetic analysis of canine kobuviruses in Tangshan, China - Zhaoyang Wang; Yajun Jiang; Xueting Liu; Weidong Lin; Qianqian Feng; Ting Xin; Xiaoyu Guo; Shaohua Hou; Hongfei Zhu; Hong Jia (Archives of Virology, 2020)

Simulation of oyster ecological carrying capacity in Sanggou Bay in the ecosystem context - Yaping Gao; Jianguang Fang; Fan Lin; Fengxue Li; Wenhao Li; Xiaoqin Wang; Meirong Du; Jinghui Fang; Weiwei Jiang; Hui Liu; Yitao Zhang; Junwei Wang; et al. (Aquaculture International, 2020)

Eddy-resolving Simulation of CAS-LICOM3 for Phase 2 of the Ocean Model Intercomparison Project - Yiwen Li; Hailong Liu; Mengrong Ding; Pengfei Lin; Zipeng Yu; Yongqiang Yu; Yao Meng; Yunlong Li; Xiaodong Jian; Jinrong Jiang; Kangjun Chen; Qian Yang; et al. (Advances in Atmospheric Sciences, 2020)
A 61-year (1958–2018) global eddy-resolving dataset for phase 2 of the Ocean Model Intercomparison Project has been produced by the version 3 of Chinese Academy of Science, the State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics/Institute of Atmospheric Physics (LASG/IAP) Climate system Ocean Model (CAS-LICOM3). The monthly and a part of the surface daily data in this study can be accessed on the Earth System Grid Federation (ESGF) node. Besides the details of the model and experiments, the evolutions and spatial patterns of large-scale and mesoscale features are also presented. The mesoscale features are reproduced well in the high-resolution simulation, as the mesoscale activities can contribute up to 50% of the total SST variability in eddy-rich regions. Also, the large-scale circulations are remarkably improved compared with the low-resolution simulation, such as the climatological annual mean SST (the RMSE is reduced from 0.59°C to 0.47°C, globally) and the evolution of Atlantic Meridional Overturning Circulation. The preliminary evaluation also indicates that there are systematic biases in the salinity, the separation location of the western boundary currents, and the magnitude of eddy kinetic energy. All these biases are worthy of further investigation.

Xanthatin mediates G 2 /M cell cycle arrest, autophagy and apoptosis via ROS/XIAP signaling in human colon cancer cells - Ya-di Geng; Lei Zhang; Guo-Yu Wang; Xiao-Jun Feng; Zhao-Lin Chen; Ling Jiang; Ai-Zong Shen (Natural Product Research, 2020)

Experimentally Induced Sepsis Causes Extensive Hypomyelination in the Prefrontal Cortex and Hippocampus in Neonatal Rats - Peixian Huang; Xuan Chen; Xiaoli Hu; Qiuping Zhou; Lanfen Lin; Shuqi Jiang; Hui Fu; Yajie Xiong; Hongke Zeng; Ming Fang; Chunbo Chen; Yiyu Deng (NeuroMolecular Medicine, 2020)

Impact of Maternal Separation on Dopamine System and its Association with Parkinson's Disease - Kai-jie He; Yu-ting Zhang; Shi-zhuang Wei; Shu-min Jiang; Lin Xu; Chao Ren; Fen Wang (NeuroMolecular Medicine, 2020)

Correction to: Telomerase reconstitution contributes to resetting of circadian rhythm in fibroblasts - Yi Qu; Meng Mao; Xihong Li; Yanyou Liu; Jianmin Ding; Zhou Jiang; Chaomin Wan; Lin Zhang; Zhengrong Wang; Dezhi Mu (Molecular and Cellular Biochemistry, 2020)

Gastrointestinal involvement of COVID-19 and potential faecal transmission of SARS-CoV-2 - Min Song; Zong-lin Li; Ye-jiang Zhou; Gang Tian; Ting Ye; Zhang-rui Zeng; Jian Deng; Hong Wan; Qing Li; Jin-bo Liu (Journal of Zhejiang University-SCIENCE B, 2020)

An Examination of the Predictability of Tropical Cyclone Genesis in High-Resolution Coupled Models with Dynamically Downscaled Coupled Data Assimilation Initialization - Mingkui Li; Shaoqing Zhang; Lixin Wu; Xiaopei Lin; Ping Chang; Gohkan Danabasoglu; Zhiqiang Wei; Xiaolin Yu; Huiqin Hu; Xiaohui Ma; Weiwei Ma; Haoran Zhao; et al. (Advances in Atmospheric Sciences, 2020)

Comparative Study between Surimi Gel and Surimi/crabmeat Mixed Gel on Nutritional Properties, Flavor Characteristics, Color, and Texture - Feng Liang; Lin Lin; Yajun Zhu; Shaotong Jiang; Jianfeng Lu (Journal of Aquatic Food Product Technology, 2020)

Identification and validation of stable quantitative trait loci for grain filling rate in common wheat (Triticum aestivum L.) - Yu Lin; Xiaojun Jiang; Yang Tao; Xilan Yang; Zhiqiang Wang; Fangkun Wu; Shihang Liu; Caixia Li; Mei Deng; Jian Ma; Guangdeng Chen; Yuming Wei; et al. (Theoretical and Applied Genetics, 2020)

Comparative analysis and natural evolution of squalene epoxidase in three Fritillaria species - Xu Lu; Lin-Ning Zhang; Jin-Fa Du; Xiao-Yan Zheng; Hui-Jun Li; Ping Li; Gui-Zhong Xin; Yan Jiang (Plant Molecular Biology, 2020)

Nitrogen and phosphorus co-starvation inhibits anthocyanin synthesis in the callus of grape berry skin - Hui-Zhen Zheng; Huan Wei; Shui-Huan Guo; Xin Yang; Ming-Xin Feng; Xu-Qiao Jin; Yu-Lin Fang; Zhen-Wen Zhang; Teng-Fei Xu; Jiang-Fei Meng (Plant Cell, Tissue and Organ Culture (PCTOC), 2020)

Interferon-α2b spray inhalation did not shorten virus shedding time of SARS-CoV-2 in hospitalized patients: a preliminary matched case-control study - Shao-rui Hao; Ren Yan; Shan-yan Zhang; Jiang-shan Lian; Huan Cai; Xiao-li Zhang; Lin Zheng; Hong-yu Jia; Jian-hua Hu; Guo-dong Yu; Jue-qing Gu; Chan-yuan Ye; et al. (Journal of Zhejiang University-SCIENCE B, 2020)

Initial chest CT findings in COVID-19: correlation with clinical features - Zhu-jing Shen; Nan Lu; Lu-lu Gao; Jian Lv; Hua-fu Luo; Ji-feng Jiang; Chao Xu; Shi-ya Li; Ju-jiang Mao; Kai Li; Xiao-pei Xu; Bin Lin (Journal of Zhejiang University-SCIENCE B, 2020)

Antibacterial activity of ruthenium polypyridyl complexes against Staphylococcus aureus and biofilms - Simeng Bu; Guijuan Jiang; Guangbin Jiang; Jinyao Liu; Xiaoli Lin; Jihong Shen; Yanshi Xiong; Xuemin Duan; Jintao Wang; Xiangwen Liao (JBIC Journal of Biological Inorganic Chemistry, 2020)

Cinnamaldehyde improves the growth performance and digestion and absorption capacity in grass carp (Ctenopharyngodon idella) - Yang Zhou; Wei-Dan Jiang; Jin-Xiu Zhang; Lin Feng; Pei Wu; Yang Liu; Jun Jiang; Sheng-Yao Kuang; Ling Tang; Yan Peng; Xiao-Qiu Zhou (Fish Physiology and Biochemistry, 2020)

The dynamic process of dietary soybean β-conglycinin in digestion, absorption, and metabolism among different intestinal segments in grass carp (Ctenopharyngodon idella) - Xu-Dong Duan; Lin Feng; Wei-Dan Jiang; Pei Wu; Yang Liu; Jun Jiang; Bei-Ping Tan; Qi-Hui Yang; Sheng-Yao Kuang; Ling Tang; Xiao-Qiu Zhou (Fish Physiology and Biochemistry, 2020)

Nakamurella albus sp. nov.: A Novel Actinobacterium Isolated from a Lichen Sample - Long-Qian Jiang; De-Feng An; Kun Zhang; Gui-Ding Li; Xin-Yu Wang; Lei Lang; Ming-Guo Jiang; Li-Song Wang; Cheng-Lin Jiang; Yi Jiang (Current Microbiology, 2020)

Experimental investigation for dynamic instability of coal-rock masses in horizontal section mining of steeply inclined coal seams - Zheng-yi Wang; Lin-ming Dou; Jiang He; An-ye Cao; Xiong-wei Li; Peng-bo Li; Chang-sheng Wu (Arabian Journal of Geosciences, 2020)

Critical transition of soil bacterial diversity and composition triggered by nitrogen enrichment - Weixing Liu; Lin Jiang; Sen Yang; Zhou Wang; Rui Tian; Ziyang Peng; Yongliang Chen; Xingxu Zhang; Jialiang Kuang; Ning Ling; Shaopeng Wang; Lingli Liu (Ecology, 2020)
Soil bacterial communities are pivotal in regulating terrestrial biogeochemical cycles and ecosystem functions. The increase in global nitrogen (N) deposition has impacted various aspects of terrestrial ecosystems, but we still have a rudimentary understanding of whether there is a threshold for N input level beyond which soil bacterial communities will experience critical transitions. Using high‐throughput sequencing of the 16S rRNA gene, we examined soil bacterial responses to a long‐term (13 yr), multi‐level, N addition experiment in a temperate steppe of northern China. We found that plant diversity decreased in a linear fashion with increasing N addition. However, bacterial diversity responded nonlinearly to N addition, such that it was unaffected by N input below 16 g N·m −2 ·yr −1 , but decreased substantially when N input exceeded 32 g N·m −2 ·yr −1 . A meta‐analysis across four N addition experiments in the same study region further confirmed this nonlinear response of bacterial diversity to N inputs. Substantial changes in soil bacterial community structure also occurred between N input levels of 16 to 32 g N·m −2 ·yr −1 . Further analysis revealed that the loss of soil bacterial diversity was primarily attributed to the reduction in soil pH, whereas changes in soil bacterial community were driven by the combination of increased N availability, reduced soil pH, and changes in plant community structure. In addition, we found that N addition shifted bacterial communities toward more putatively copiotrophic taxa. Overall, our study identified a threshold of N input level for bacterial diversity and community composition. The nonlinear response of bacterial diversity to N input observed in our study indicates that although bacterial communities are resistant to low levels of N input, further increase in N input could trigger a critical transition, shifting bacterial communities to a low‐diversity state.

The undrained vertical and horizontal bearing capacity of internal skirted foundation in clay - Chong Jiang; Liu Lin; Chen Li; Tian-Bin Li; Jiali He (European Journal of Environmental and Civil Engineering, 2020)

Acanthophoraine A, a new pyrrolidine alkaloid from the red alga Acanthophora spicifera - Jia-Li Lin; Yong-Qian Liang; Xiao-Jian Liao; Jian-Ting Yang; Dai-Chun Li; Yu-Ling Huang; Zhi-Hui Jiang; Shi-Hai Xu; Bing-Xin Zhao (Natural Product Research, 2020)

Instantaneous phase inversion based on an unwrapping algorithm - Yu-Zhao Lin; Zhen-Chun Li; Kai Zhang; Ren-Wei Ding; Ping Jiang (Applied Geophysics, 2020)

High-level soluble expression of human Cu,Zn superoxide dismutase with high activity in Escherichia coli - Jin-Ling Yang; Xing-Lun Li; Feng-Lin Jiang; Ting Gong; Jing-Jing Chen; Tian-Jiao Chen; Ping Zhu (World Journal of Microbiology and Biotechnology, 2020)

An Efficient Catalytic Composite Material of Mesoporous Carbon Loaded Nano Zero-Valent Iron as an Activator for the Degradation of Sulfadiazine - Liangbo Zhang; Yinghui Guo; Ruzhen Xie; Lin Chen; Wenju Jiang; Xia Jiang (Water, Air, & Soil Pollution, 2020)

Beyond resource limitation: an expanded test of the niche dimension hypothesis for multiple types of niche axes - Xuebin Yan; Jeffrey Diez; Kailing Huang; Shaopeng Li; Xi Luo; Xinyu Xu; Fanglong Su; Lin Jiang; Hui Guo; Shuijin Hu (Oecologia, 2020)

Pseudomonas syringae dual‐function protein Lon switches between virulence and metabolism by acting as both DNA ‐binding transcriptional regulator and protease in different environments - Canfeng Hua; Tingting Wang; Xiaolong Shao; Yingpeng Xie; Hao Huang; Jingui Liu; Weitong Zhang; Yingchao Zhang; Yiqing Ding; Lin Jiang; Xin Wang; Xin Deng (Environmental Microbiology, 2020)
Summary Lon, a member of the AAA+ protease family, plays vital roles in Type III secretion systems (T3SS), agglutination and colony shape in the model plant pathogen Pseudomonas syringae . Lon also functions as a transcriptional regulator in other bacterial species such as Escherichia coli and Brevibacillus thermoruber . To reveal the molecular mechanisms of Lon as a dual‐function protein in P . syringae , we studied Lon‐regulated genes by using RNA sequencing (RNA‐seq), chromatin immunoprecipitation sequencing (ChIP‐seq) and liquid chromatography–tandem mass spectrometry. As a transcriptional regulator, Lon directly regulated a group of genes (PSPPH_4788, gacA , fur , gntR , clpS , lon and glyA ) and consequently regulated their functions, such as 1‐dodecanol oxidation activity, motility, pyoverdine production, glucokinase activity, N‐end rule pathway, lon expression and serine hydroxymethyltransferase activity. Mass spectrometry results revealed that the expression levels of five T3SS proteins (such as HrcV, HrpW1) were higher in the ∆ lon strain than the wild‐type (WT) strain in KB. In MM, 12 metabolic proteins (such as AcdS and NuoI) showed lower levels in the ∆ lon strain than the WT strain. Taken together, these data demonstrate that the dual‐function protein Lon sophisticatedly regulates virulence and metabolism in P . syringa e.

The chemical constituents from the active fractions of Eleutherine bulbosa with their antimicrobial activity - Hai Jiang; Wen-Jing Man; A-Jiao Hou; Lin Yang; Xu-Dong Xing; Mei-Ling Yan; Xin-Yue Guo; Liu Yang (Natural Product Research, 2020)

Experimental demonstration of the importance of keystone communities for maintaining metacommunity biodiversity and ecosystem functioning - Xian Yang; Jiaqi Tan; Kevin Harry Sun; Lin Jiang (Oecologia, 2020)

Beneficial consequences of Lupeol on middle cerebral artery-induced cerebral ischemia in the rat involves Nrf2 and P38 MAPK modulation - Zhiyuan Zhang; Chongfu Xu; Jiheng Hao; Meng Zhang; Zidong Wang; Tengkun Yin; Kai Lin; Weidong Liu; Qunlong Jiang; Zhongchen Li; Dan Wang; Zhiqi Mao; et al. (Metabolic Brain Disease, 2020)

Screening of three Chlorella mutant strains with high lipid production induced by 3 types of lasers - Kang Wang; Bin Lin; Chunxiao Meng; Zhengquan Gao; Zhe Li; Haonan Zhang; Huanmin Du; Fei Xu; Xiao Jiang (Journal of Applied Phycology, 2020)

Effect of proton pump inhibitors on voriconazole concentrations in Chinese patients with malignant hematological diseases - Qi Huang; Qiong Liu; Tao Yin; Lin Hu; Hanjun Ding; Shao Liu; Yueping Jiang (European Journal of Clinical Pharmacology, 2020)

Effect of nutritional factors on the accretion of secondary metabolites in Malaysian ginseng adventitious root cultures - Xi-Hua Cui; Hosakatte Niranjana Murthy; Ji-De Zhang; Hang-Lin Song; Yin-Ji Jiang; Wen-Wen Qi; Yong Yi Li; Kee-Yoeup Paek; So-Young Park (Plant Biotechnology Reports, 2020)

Spatial Relationships of Water Resources with Energy Consumption at Coal Mining Operations in China - Gang Lin; Dong Jiang; Jingying Fu; Donglin Dong; Wenjie Sun; Xiang Li (Mine Water and the Environment, 2020)

Grenville-age orogenic event along the northeastern margin of the Quanji massif, NW China: constraints from ~1.1 Ga migmatite - Zhouxuan Xiao; Licheng Ma; Wan Jiang; Ran Wang; Yuyan Yao; Jie Cai; Jingyu Lin; Lu Li (Geosciences Journal, 2020)

Erratum to: LICOM Model Datasets for the CMIP6 Ocean Model Intercomparison Project - Pengfei Lin; Zipeng Yu; Hailong Liu; Yongqiang Yu; Yiwen Li; Jinrong Jiang; Wei Xue; Kangjun Chen; Qian Yang; Bowen Zhao; Jilin Wei; Mengrong Ding; et al. (Advances in Atmospheric Sciences, 2020)

Regional disparities of phytoplankton in relation to different water masses in the Northwest Pacific Ocean during the spring and summer of 2017 - Gengming Lin; Yanghang Chen; Jiang Huang; Yanguo Wang; Youyin Ye; Qingliang Yang (Acta Oceanologica Sinica, 2020)

Hypertrophic olivary degeneration: a single case report - Wei Jiang; Xiao-Zhong Jing; Lin Gan; Ming Dong; Peng Yu (Acta Neurologica Belgica, 2020)

Plastic pollution in croplands threatens long‐term food security - Dan Zhang; Ee Ling Ng; Wanli Hu; Hongyuan Wang; Pablo Galaviz; Hude Yang; Wentao Sun; Chongxiao Li; Xingwang Ma; Bin Fu; Peiyi Zhao; Fulin Zhang; et al. (Global Change Biology, 2020)
Plastic pollution is a global concern given its prevalence in aquatic and terrestrial ecosystems. Studies have been conducted on the distribution and impact of plastic pollution in marine ecosystems, but little is known on terrestrial ecosystems. Plastic mulch has been widely used to increase crop yields worldwide, yet the impact of plastic residues in cropland soils to soil health and crop production in the long term remained unclear. In this paper, using a global meta‐analysis, we found that the use of plastic mulch can indeed increase crop yields on average by 25%–42% in the immediate season due to the increase of soil temperature (+8%) and moisture (+17%). However, the unabated accumulation of film residues in the field negatively impacts its physicochemical properties linked to healthy soil and threatens food production in the long term. It has multiple negative impacts on plant growth including crop yield (at the mean rate of −3% for every additional 100 kg/ha of film residue), plant height (−2%) and root weight (−5%), and soil properties including soil water evaporation capacity (−2%), soil water infiltration rate (−8%), soil organic matter (−0.8%) and soil available phosphorus (−5%) based on meta‐regression. Using a nationwide field survey of China, the largest user of plastic mulch worldwide, we found that plastic residue accumulation in cropland soils has reached 550,800 tonnes, with an estimated 6%–10% reduction in cotton yield in some polluted sites based on current level of plastic residue content. Immediate actions should be taken to ensure the recovery of plastic film mulch and limit further increase in film residue loading to maintain the sustainability of these croplands.

Detection of serum IgM and IgG for COVID-19 diagnosis - Ling Zhong; Junlan Chuan; Bo Gong; Ping Shuai; Yu Zhou; Yi Zhang; Zhilin Jiang; Dingding Zhang; Xiaoqi Liu; Shi Ma; Yi Huang; He Lin; et al. (Science China Life Sciences, 2020)

Comparison of epidemiological and clinical characteristics of COVID-19 patients with and without Wuhan exposure - Jiang-shan Lian; Huan Cai; Shao-rui Hao; Xi Jin; Xiao-li Zhang; Lin Zheng; Hong-yu Jia; Jian-hua Hu; Shan-yan Zhang; Guo-dong Yu; Jue-qing Gu; Chan-yuan Ye; et al. (Journal of Zhejiang University-SCIENCE B, 2020)

Effects of long-term planting on PhytOC storage and its distribution in soil physical fractions in Moso bamboo forests in subtropical China - Chengpeng Huang; Yongchun Li; Lin Jin; Xiaoqiang Gong; Jiasen Wu; Da Dong; Scott X. Chang; Peikun Jiang (Journal of Soils and Sediments, 2020)

Interaction between serine carboxypeptidase-like protein TtGS5 and Annexin D1 in developing seeds of Triticum timopheevi - Peihong Jiang; JianSheng Gao; Junyi Mu; Luning Duan; Yunsong Gu; Shichen Han; Lin Chen; Yaxuan Li; Yueming Yan; Xiaohui Li (Journal of Applied Genetics, 2020)

Comparative transcriptomic analysis of vascular endothelial cells after hypoxia/re-oxygenation induction based on microarray technology - Jia Xu; Jiu-kun Jiang; Xiao-lin Li; Xiao-peng Yu; Ying-ge Xu; Yuan-qiang Lu (Journal of Zhejiang University-SCIENCE B, 2020)

Correction to: AVE0991, a nonpeptide angiotensin-(1–7) mimic, inhibits angiotensin II–induced abdominal aortic aneurysm formation in apolipoprotein E knockout mice - Hui Ma; Yu-Lin Wang; Nai-Hao Hei; Jun-Long Li; Xin-Ran Cao; Bo Dong; Wen-jiang Yan (Journal of Molecular Medicine, 2020)

AVE0991, a nonpeptide angiotensin-(1–7) mimic, inhibits angiotensin II–induced abdominal aortic aneurysm formation in apolipoprotein E knockout mice - Hui Ma; Yu-Lin Wang; Nai-Hao Hei; Jun-Long Li; Xin-Ran Cao; Bo Dong; Wen-jiang Yan (Journal of Molecular Medicine, 2020)

Heat stress induces apoptosis through disruption of dynamic mitochondrial networks in dairy cow mammary epithelial cells - Kun-Lin Chen; Hui-Li Wang; Lin-Zheng Jiang; Yong Qian; Cai-Xia Yang; Wei-Wei Chang; Ji-Feng Zhong; Guang-Dong Xing (In Vitro Cellular & Developmental Biology - Animal, 2020)

Impacts of elevated temperature and pCO2 on the brooded larvae of Pocillopora damicornis from Luhuitou Reef, China: evidence for local acclimatization - Lei Jiang; Ming-Lan Guo; Fang Zhang; Yu-Yang Zhang; Guo-Wei Zhou; Xin-Ming Lei; Xiang-Cheng Yuan; You-Fang Sun; Tao Yuan; Lin Cai; Jian-Sheng Lian; Sheng Liu; et al. (Coral Reefs, 2020)