Betanodavirus induces RIPK3/MLKL-mediated necroptosis and IL-21/adaptive immune response via superoxide stress/mTOR/ULK1-mediated autophagy signal in the context of brain damage in grouper (Epinephelus coioides) - Hong-Jun Liao; Kuang-Wen Chen; Hsing-Ni Lin; Pei-Cih Gong; Jen-Leih Wu; Jiann-Ruey Hong (Fish & Shellfish Immunology, 2026)

DHA affects ISKNV-induced autophagy flux via the AMPK/mTOR/ULK1 and BECN1/SQSTM1 axes, limiting viral replication in fish cells - Kuang-Wen Chen; Chien-Fu Huang; Jen-Leih Wu; Jiann-Ruey Hong (Fish & Shellfish Immunology, 2026)

Enhancement of reactive oxygen species metabolism by antioxidant enzyme Cu/Zn-SOD can block betanodavirus-induced necroptosis and suppress viral replication in fish cells - Hong-Jun Liao; Jiann-Ruey Hong (Fish & Shellfish Immunology, 2025)

Complete genome sequence and phylogenetic analysis of megalocytivirus RSIV-Ku: A natural recombination infectious spleen and kidney necrosis virus - Jing-Yi Shiu; Jiann-Ruey Hong; Chen-Chun Ku; Chiu-Ming Wen (Archives of Virology, 2018)

GSIV serine/threonine kinase can induce apoptotic cell death via p53 and pro-apoptotic gene Bax upregulation in fish cells - Latif Reshi; Horng-Cherng Wu; Jen-Leih Wu; Hao-Ven Wang; Jiann-Ruey Hong (Apoptosis, 2016)

Betanodavirus up-regulates chaperone GRP78 via ER stress: roles of GRP78 in viral replication and host mitochondria-mediated cell death - Yu-Chin Su; Jen-Leih Wu; Jiann-Ruey Hong (Apoptosis, 2011)

Inducible Male Infertility by Targeted Cell Ablation in Zebrafish Testis - Chia-Chun Hsu; Min-Fon Hou; Jiann-Ruey Hong; Jen-Leih Wu; Guor Mour Her (Marine Biotechnology, 2010)

Aquatic birnavirus capsid protein, VP3, induces apoptosis via the Bad-mediated mitochondria pathway in fish and mouse cells - Chien-Li Chiu; Jen-Leih Wu; Guor-Mour Her; Yi-Li Chou; Jiann-Ruey Hong (Apoptosis, 2010)

Anti-Bcl-2 family members, zfBcl-xL and zfMcl-1a, prevent cytochrome c release from cells undergoing betanodavirus-induced secondary necrotic cell death - Shi-Ping Chen; Jen-Leih Wu; Yu-Chin Su; Jiann-Ruey Hong (Apoptosis, 2007)