Differences in Transcriptomic Profiles of Brain and Thyroid Tumors with NTRK Gene Rearrangement - A. A. Kechin; M. A. Koryukov; M. A. Smertina; V. S. Borobova; I. P. Oscorbin; A. A. Ivanov; S. Yu. Bakharev; U. A. Boyarskikh; N. E. Kushlinskii; M. L. Filipenko (Bulletin of Experimental Biology and Medicine, 2023)

Restoring source rock initial quality and quantity with kinetic-based inversion - Applied to the Wolfcamp play in the Permian Delaware Basin - Anindito S. Baskoro; Friedemann Baur; Alan Z. Yu; Ethan L. Grossman (Marine and Petroleum Geology, 2023)

Distinctive role of soil type and land use in driving bacterial communities and carbon cycling functions down soil profiles - Peipei Xue; Budiman Minasny; Alex McBratney; Neil L. Wilson; Yijia Tang; Yu Luo (CATENA, 2023)

Neuroinflammatory mediators in acquired epilepsy: an update - Yu Chen; Marwa M. Nagib; Nelufar Yasmen; Madison N. Sluter; Taylor L. Littlejohn; Ying Yu; Jianxiong Jiang (Inflammation Research, 2023)

Altered cerebral blood flow in older adults with Alzheimer’s disease: a systematic review - Cecily G. Swinford; Shannon L. Risacher; Yu-Chien Wu; Liana G. Apostolova; Sujuan Gao; Paula J. Bice; Andrew J. Saykin (Brain Imaging and Behavior, 2023)

Effect of Melatonin on the Content of CD3low and CD3hi T Cells in the Thymus of Mice with Functional Pinealectomy - S. V. Michurina; S. M. Miroshnichenko; I. Yu. Ishchenko; A. E. Serykh; L. N. Rachkovskaya (Bulletin of Experimental Biology and Medicine, 2023)

Bioturbation in sediment cores from the Clarion-Clipperton Zone in the northeast Pacific: Evidence from excess 210Pb - W. Yu; F. Lin; L. Lin (Marine Pollution Bulletin, 2023)

On-road mobile mapping of spatial variations and source contributions of ammonia in Beijing, China - Weiwei Pu; Jiujiang Sheng; Ping Tian; Mengyu Huang; Xiangxue Liu; Jeffrey L. Collett; Ziming Li; Xiujuan Zhao; Di He; Fan Dong; Nannan Zhang; Weijun Quan; et al. (Science of The Total Environment, 2023)

Comprehensive compositional assessment of bioactive compounds in diverse pea accessions - Xiumei Han; Leonid Akhov; Paula Ashe; Courteney Lewis; Leah Deibert; L. Irina Zaharia; Lily Forseille; Daoquan Xiang; Raju Datla; Matthew Nosworthy; Carol Henry; Jitao Zou; et al. (Food Research International, 2023)

Epilepsy in Angelman’s Syndrome - M. Yu. Bobylova; K. Yu. Mukhin; G. V. Kuzmich; L. Yu. Glukhova; O. A. Pylayeva (Neuroscience and Behavioral Physiology, 2023)

DNA sequence-specific ligands. XX. Synthesis, spectral properties, virological and biochemical studies of fluorescent dimeric trisbenzimidazoles DB3P(n) - Albert F. Arutyunyan; Alexey A. Kostyukov; Vladislav A. Lushpa; Konstantin S. Mineev; Sergey P. Korolev; Marina B. Gottikh; Regina R. Klimova; Alla A. Kushch; Kseniya V. Kalabina; Olga Yu. Susova; Alexei L. Zhuze (Medicinal Chemistry Research, 2023)

The coincineration of sewage sludge and municipal solid waste in an industrial scale incineration power plant - S. He; K. Chen; Y. Zhang; Y. Cheng; S. Liu; B. Yu; L. Wang; X. Wang (International Journal of Environmental Science and Technology, 2023)

Extended seasonal prediction of spring precipitation over the Upper Colorado River Basin - Siyu Zhao; Rong Fu; Michael L. Anderson; Sudip Chakraborty; Jonathan H. Jiang; Hui Su; Yu Gu (Climate Dynamics, 2023)
This study provides extended seasonal predictions for the Upper Colorado River Basin (UCRB) precipitation in boreal spring using an artificial neural network (ANN) model and a stepwise linear regression model, respectively. Sea surface temperature (SST) predictors are developed taking advantage of the correlation between the precipitation and SST over three ocean basins. The extratropical North Pacific has a higher correlation with the UCRB spring precipitation than the tropical Pacific and North Atlantic. For the ANN model, the Pearson correlation coefficient between the observed and predicted precipitation exceeds 0.45 ( p -value < 0.01) for a lead time of 12 months. The mean absolute percentage error (MAPE) is below 20% and the Heidke skill score (HSS) is above 50%. Such long-lead prediction skill is probably due to the UCRB soil moisture bridging the SST and precipitation. The stepwise linear regression model shows similar prediction skills to those of ANN. Both models show prediction skills superior to those of an autoregression model (correlation < 0.10) that represents the baseline prediction skill and those of three of the North American Multi-Model Ensemble (NMME) forecast models. The three NMME models exhibit different skills in predicting the precipitation, with the best skills of the correlation ~ 0.40, MAPE < 25%, and HSS > 40% for lead times less than 8 months. This study highlights the advantage of oceanic climate signals in extended seasonal predictions for the UCRB spring precipitation and supports the improvement of the UCRB streamflow prediction and related water resource decisions.

Hypotensive Effects of Arginase Inhibition by L-Norvaline in Genetic Models of Normotensive and Hypertensive Rats - M. A. Gilinsky; Yu. K. Polityko; A. L. Markel; L. I. Aftanas (Bulletin of Experimental Biology and Medicine, 2023)

Incipiently social carpenter bees ( Xylocopa ) host distinctive gut bacterial communities and display geographical structure as revealed by full‐length PacBio 16S rRNA sequencing - Madeline Y. Handy; Dino L. Sbardellati; Michael Yu; Nicholas W. Saleh; Madeleine M. Ostwald; Rachel L. Vannette (Molecular Ecology, 2023)
The gut microbiota of bees affects nutrition, immunity and host fitness, yet the roles of diet, sociality and geographical variation in determining microbiome structure, including variant‐level diversity and relatedness, remain poorly understood. Here, we use full‐length 16S rRNA amplicon sequencing to compare the crop and gut microbiomes of two incipiently social carpenter bee species, Xylocopa sonorina and Xylocopa tabaniformis , from multiple geographical sites within each species' range. We found that Xylocopa species share a set of core taxa consisting of Bombilactobacillus , Bombiscardovia and Lactobacillus , found in >95% of all individual bees sampled, and Gilliamella and Apibacter were also detected in the gut of both species with high frequency. The crop bacterial community of X. sonorina comprised nearly entirely Apilactobacillus with occasionally abundant nectar bacteria. Despite sharing core taxa, Xylocopa species' microbiomes were distinguished by multiple bacterial lineages, including species‐specific variants of core taxa. The use of long‐read amplicons revealed otherwise cryptic species and population‐level differentiation in core microbiome members, which was masked when a shorter fragment of the 16S rRNA (V4) was considered. Of the core taxa, Bombilactobacillus and Bombiscardovia exhibited differentiation in amplicon sequence variants among bee populations, but this was lacking in Lactobacillus , suggesting that some bacterial genera in the gut may be structured by different processes. We conclude that these Xylocopa species host a distinctive microbiome, similar to that of previously characterized social corbiculate apids, which suggests that further investigation to understand the evolution of the bee microbiome and its drivers is warranted.

A critical thermal transition driving spring phenology of Northern Hemisphere conifers - Jian‐Guo Huang; Yaling Zhang; Minhuang Wang; Xiaohan Yu; Annie Deslauriers; Patrick Fonti; Eryuan Liang; Harri Mäkinen; Walter Oberhuber; Cyrille B. K. Rathgeber; Roberto Tognetti; Václav Treml; et al. (Global Change Biology, 2023)
Despite growing interest in predicting plant phenological shifts, advanced spring phenology by global climate change remains debated. Evidence documenting either small or large advancement of spring phenology to rising temperature over the spatio‐temporal scales implies a potential existence of a thermal threshold in the responses of forests to global warming. We collected a unique data set of xylem cell‐wall‐thickening onset dates in 20 coniferous species covering a broad mean annual temperature (MAT) gradient (−3.05 to 22.9°C) across the Northern Hemisphere (latitudes 23°–66° N). Along the MAT gradient, we identified a threshold temperature (using segmented regression) of 4.9 ± 1.1°C, above which the response of xylem phenology to rising temperatures significantly decline. This threshold separates the Northern Hemisphere conifers into cold and warm thermal niches, with MAT and spring forcing being the primary drivers for the onset dates (estimated by linear and Bayesian mixed‐effect models), respectively. The identified thermal threshold should be integrated into the Earth‐System‐Models for a better understanding of spring phenology in response to global warming and an improved prediction of global climate‐carbon feedbacks.

The Role of the Dentate Gyrus in Mediating Hippocampal Functions: The Epileptic Brain - V. F. Kitchigina; L. V. Shubina; I. Yu. Popova (Neuroscience and Behavioral Physiology, 2023)

The Role of the Dentate Gyrus in Mediating Hippocampal Functions: The Healthy Brain - V. F. Kitchigina; L. V. Shubina; I. Yu. Popova (Neuroscience and Behavioral Physiology, 2023)

Strong Genetic Structure and Limited Gene Flow among Populations of the Tropical Seagrass Thalassia hemprichii in the Philippines - Yuichi Nakajima; Yu Matsuki; Miguel D. Fortes; Wilfredo H. Uy; Wilfredo L. Campos; Kazuo Nadaoka; Chunlan Lian (Journal of Marine Science and Engineering, 2023)
Seagrasses are marine angiosperms, and seagrass beds maintain the species diversity of tropical and subtropical coastal ecosystems. For proper understanding, management and conservation of coastal ecosystems, it is essential to understand seagrass population dynamics. Population genetic studies can cover large geographic scales and contribute to a comprehensive understanding of reproductive dynamics and potential dispersal among locations. The clonal and genetic diversity and genetic connectivity of Thalassia hemprichii in the Philippines were estimated by a population genetics approach. The geographic scale of this study has a direct distance of approximately 1600 km. Although high clonal diversity was found in some sites (R = 0.07–1.00), both sexual and asexual reproduction generally maintains separate populations. Genetic diversity is not definitely correlated with latitude, and genetic differentiation is significant in all pairs of sites (FST = 0.026–0.744). Complex genetic structure was found in some regions, even at a fine geographic scale. The migration of fruits and seedlings was elucidated as an infrequent and stochastic event. These results suggest the necessity for the conservation of this species due to a deficiency in migrants from external regions.

Analysis of spatiotemporal variation in dissolved organic carbon concentrations for streams with cropland-dominated watersheds - Yong Q. Tian; Qian Yu; Hunter J. Carrick; Brian L. Becker; Remegio Confesor; Mark Francek; Olivia C. Anderson (Science of The Total Environment, 2023)

Aerosolized aqueous dust extracts collected near a drying lake trigger acute neutrophilic pulmonary inflammation reminiscent of microbial innate immune ligands - Trevor A. Biddle; Keziyah Yisrael; Ryan Drover; Qi Li; Mia R. Maltz; Talyssa M. Topacio; Jasmine Yu; Diana Del Castillo; Daniel Gonzales; Hannah L. Freund; Mark P. Swenson; Malia L. Shapiro; et al. (Science of The Total Environment, 2023)

A study of iodine concentration in drinking waters of Bryansk and Oryol regions - V. Yu. Berezkin; L. I. Kolmykova; G. A. Kulieva (Environmental Geochemistry and Health, 2023)

Relationships Between Urinary Metals and Diabetes Traits Among Mexican Americans in Starr County, Texas, USA - Margaret C. Weiss; Yu-Hsuan Shih; Molly Scannell Bryan; Brian P. Jackson; David Aguilar; Craig L. Hanis; Maria Argos; Robert M. Sargis (Biological Trace Element Research, 2023)

Effect of Changes in the Redox Status on Biofilm Formation in Escherichia coli - T. V. Kalashnikova; L. V. Sutormina; Z. Yu. Samoilova; O. N. Oktyabrsky; G. V. Smirnova (Bulletin of Experimental Biology and Medicine, 2023)

MTNR1A and MTNR1B Gene Variants of the Melatonin Receptor and Arterial Stiffness in Persons without Arterial Hypertension - S. N. Kolomeichuk; V. A. Korneva; T. Yu. Kuznetsova; L. S. Korostovtseva; M. V. Bochkarev; Yu.V. Sviryaev; M. L. Blagonravov (Bulletin of Experimental Biology and Medicine, 2023)

Endothelial cell expression of mutant Map2k1 causes vascular malformations in mice - Patrick J. Smits; Christopher L. Sudduth; Dennis J. Konczyk; Yu Sheng Cheng; Matthew P. Vivero; Harry P. W. Kozakewich; Matthew L. Warman; Arin K. Greene (Angiogenesis, 2023)

Responses of a semiarid grassland to recurrent drought are linked to community functional composition - Wentao Luo; Taofeek O. Muraina; Robert J. Griffin‐Nolan; Wang Ma; Lin Song; Wei Fu; Qiang Yu; Alan K. Knapp; Zhengwen Wang; Xingguo Han; Scott L. Collins (Ecology, 2023)
Recurrent droughts are an inevitable consequence of climate change, yet how grasslands respond to such events is unclear. We conducted a 6‐year rainfall manipulation experiment in a semiarid grassland that consisted of an initial 2‐year drought (2015–2016), followed by a recovery period (2017–2018) and, finally, a second 2‐year drought (2019–2020). In each year, we estimated aboveground net primary productivity (ANPP), species richness, community‐weighted mean (CWM) plant traits, and several indices of functional diversity. The initial drought led to reduced ANPP, which was primarily driven by limited growth of forbs in the first year and grasses in the second year. Total ANPP completely recovered as the rapid recovery of grass productivity compensated for the slow recovery of forb productivity. The subsequent drought led to a greater reduction in total ANPP than the initial drought due to the greater decline of both grass and forb productivity. The structural equation models revealed that soil moisture influenced ANPP responses directly during the initial drought, and indirectly during the subsequent drought by lowering functional diversity, which resulted in reduced total ANPP. Additionally, ANPP was positively influenced by CWM plant height and leaf nitrogen during the recovery period and recurrent drought, respectively. Overall, the greater impact of the second drought on ecosystem function than the initial drought, as well as the underlying differential mechanism, underscores the need for an understanding of how increased drought frequency may alter semiarid grassland functioning.

Prediction of enteric methane emissions by sheep using an intercontinental database - Alejandro Belanche; Alexander N. Hristov; Henk J. van Lingen; Stuart E. Denman; Ermias Kebreab; Angela Schwarm; Michael Kreuzer; Mutian Niu; Maguy Eugène; Vincent Niderkorn; Cécile Martin; Harry Archimède; et al. (Journal of Cleaner Production, 2023)

Structural characterization of SARS-CoV-2 dimeric ORF9b reveals potential fold-switching trigger mechanism - Xiyue Jin; Xue Sun; Yan Chai; Yu Bai; Ying Li; Tianjiao Hao; Jianxun Qi; Hao Song; Catherine C. L. Wong; George F. Gao (Science China Life Sciences, 2023)

Single-cell technologies uncover intra-tumor heterogeneity in childhood cancers - Yu-Chen Lo; Yuxuan Liu; Marte Kammersgaard; Abhishek Koladiya; Timothy J. Keyes; Kara L. Davis (Seminars in Immunopathology, 2023)

Effects of Fragment ACTH15-18 and Its Analog ACTH15-18Pro-Gly-Pro on the Sequelae of Acute Stress - D. M. Manchenko; N. Yu. Glazova; E. A. Sebentsova; L. A. Andreeva; O. V. Dolotov; A. A. Kamensky; N. F. Myasoedov; N. G. Levitskaya (Neuroscience and Behavioral Physiology, 2023)

Impairments to Emotional and Behavioral Regulation in Children with Attention Deficit Hyperactivity Disorder - L. S. Chutko; E. A. Yakovenko; S. Yu. Surushkina; T. I. Anisimova; A. V. Sergeev; M. D. Didur; D. V. Cherednichenko (Neuroscience and Behavioral Physiology, 2023)

Constructional Features of a Multielectrode Electrocardiology Screening System - M. N. Kramm; O. N. Bodin; A. Yu. Bodin; T. L. N. Truong; G. V. Zhikhareva (Biomedical Engineering, 2023)

Cooperative feeding and foraging lateralization by Eden's whales off southern China - Bingyao Chen; Caiwen Wu; Lisa T Ballance; Dagmar Fertl; Huiping Jiang; Ying Qiao; Zhuoxuan Du; Yu Zhang; Feng Yang; Guang Yang; Robert L. Pitman (Marine Mammal Science, 2023)
We investigated surface feeding behaviors of Eden's whales ( Balaenoptera edeni edeni ) in northern Beibu Gulf, southern China, between April 3, 2018, and April 26, 2021. During 122 days at sea, 1,065 individual feeding events were recorded, and eight feeding behaviors were identified: two nonlunging (tread‐water and/or trap‐feeding, 7.7%, and a novel behavior we call “pirouette feeding,” 15.3%) and six lunging (right lateral lunging, RLL, 10.9%; left lateral lunging, 0.2%; upright lunging, 6.3%, vertical lunging, 18.5%; inverted lunging, 0.3%; cooperative lateral lunging, COL, 40.9%). During COL, 2–8 whales swam clockwise around a fish school and simultaneously performed RLL on surfacing—the first cooperative feeding behavior recorded for a Balaenoptera whale. Five lateralized feeding behaviors (entailing either a left or right rotation on the long‐body axis) accounted for 65.8% of individual feeding events, with a strong right‐side bias (99.7%). Lateralized behavior is prevalent in many vertebrates, including several species of rorquals, and we suggest that the right‐biased foraging lateralization among rorquals specifically allows them to keep their right eye on their prey (i.e., a sensory versus motor lateralization), and that this shared asymmetry among conspecifics may have preadapted Eden's whale for cooperative foraging.

Distribution analysis, updated checklist, and DNA barcodes of the endemic vascular flora of the Altai mountains, a Siberian biodiversity hotspot - A.S. Erst; A.YU. Nikulin; V.YU. Nikulin; A.L. Ebel; E.V. Zibzeev; M.T. Sharples; S. Baasanmunkh; Hyeok JAE Choi; M.V. Olonova; A.I. Pyak; I.I. Gureyeva; T.V. Erst; et al. (Systematics and Biodiversity, 2022)

Age-Related Features of Ketanserin Effects in Experimental Liver Cirrhosis - E. S. Pan; A. V. Pakhomova; N. N. Ermakova; S. A. Afanas’ev; Т. Yu. Rebrova; М. А. Zhukova; L. А. Sandrikina; О. D. Putrova; L. V. Kogai; О. V. Pershina; А. М. Dygai; Е. G. Skurikhin (Bulletin of Experimental Biology and Medicine, 2022)

Correlation of the regenerative potential of dermal fibroblasts in 2D culture with the biological properties of fibroblast-derived tissue spheroids - Elizaveta V. Koudan; Alla I. Zorina; Aleksandr A. Levin; Frederico D. A. S. Pereira; Stanislav V. Petrov; Saida Sh. Karshieva; Vladimir A. Kasyanov; Natalya E. Manturova; Andrey Yu. Ustyugov; Nikolay N. Potekaev; Vladislav A. Parfenov; Pavel A. Karalkin; et al. (Cell and Tissue Research, 2022)

Electronic cigarette vaping with aged coils causes acute lung injury in mice - Shunsaku Goto; Robert M. H. Grange; Riccardo Pinciroli; Ivy A. Rosales; Rebecca Li; Sophie L. Boerboom; Katrina F. Ostrom; Eizo Marutani; Hatus V. Wanderley; Aranya Bagchi; Robert B. Colvin; Lorenzo Berra; et al. (Archives of Toxicology, 2022)

A study of peatland-derived dissolved organic matter from headstream to sea using multiple analytical tools - François L. L. Muller; Kuei-Chen Chang; Yu-Chieh Wang; Chon-Lin Lee (Environmental Science and Pollution Research, 2022)

A 10-miRNA risk score-based prediction model for pathological complete response to neoadjuvant chemotherapy in hormone receptor-positive breast cancer - Chang Gong; Ziliang Cheng; Yaping Yang; Jun Shen; Yingying Zhu; Li Ling; Wanyi Lin; Zhigang Yu; Zhihua Li; Weige Tan; Chushan Zheng; Wenbo Zheng; et al. (Science China Life Sciences, 2022)

Predictive Model of Rainfall-Induced Landslides in High-Density Urban Areas of the South Primorsky Region (Russia) - Yu. A. Stepnova; A. A. Stepnov; A. V. Konovalov; Yu. V. Gensiorovskiy; V. A. Lobkina; L. E. Muzychenko; A. A. Muzychenko; A. A. Orekhov (Pure and Applied Geophysics, 2022)

The Experience of Using Multipotent Mesenchymal Stromal Cells in the Treatment of Severe Recurrent Cholangitis in Children with Biliary Atresia after Kasai Surgery - A. V. Degtyareva; М. H. Isaeva; D. N. Silachev; K. V. Goryunov; Yu. А. Shevtsova; I. V. Dubrovina; A. A. Burov; E. A. Filippova; V. V. Zubkov; L. V. Krechetova; V. V. Vtorushina; E. V. Inviyaeva; et al. (Bulletin of Experimental Biology and Medicine, 2022)

Light-Induced Functional Pinealectomy. Effect on the Thymus of C57BL/6 Mice - S. V. Michurina; S. M. Miroshnichenko; A. E. Serykh; I. Yu. Ishchenko; A. Yu. Letyagin; E. L. Zavjalov (Bulletin of Experimental Biology and Medicine, 2022)

SIRT3 Promotes the Development of Esophageal Squamous Cell Carcinoma by Regulating Hexokinase 2 through the AKT Signaling Pathway - M. L. Yuan; L. H. Ren; X. C. Yu; J. W. Dong; R. H. Shi (Bulletin of Experimental Biology and Medicine, 2022)

Determination of the Mechanical Properties of Contemporary Dental Composite Materials by a Stretching Method - E. E. Maiorov; L. I. Shalamai; E. Yu Mendosa; V. B. Lampusova; N. S. Oksas (Biomedical Engineering, 2022)

A Perfusion Bioreactor for Long-Term Studies of the Dynamics of the Formation of a Tissue Equivalent - Yu. B. Basok; A. M. Grigor’ev; L. A. Kirsanova; A. D. Kirillova; V. I. Sevast’yanov (Biomedical Engineering, 2022)

A Population Pharmacokinetic Modelling Approach to Unravel the Complex Pharmacokinetics of Vincristine in Children - A. Laura Nijstad; Wan-Yu Chu; Evelien de Vos-Kerkhof; Catherine F. Enters-Weijnen; Mirjam E. van de Velde; Gertjan J. L. Kaspers; Shelby Barnett; Gareth J. Veal; Arief Lalmohamed; C. Michel Zwaan; Alwin D. R. Huitema (Pharmaceutical Research, 2022)
Background Vincristine, a chemotherapeutic agent that extensively binds to β-tubulin, is commonly dosed at 1.4–2.0 mg/m 2 capped at 2 mg. For infants, doses vary from 0.025–0.05 mg/kg or 50–80% of the mg/m 2 dose. However, evidence for lower doses in infants compared to older children is lacking. This study was conducted to unravel the complex pharmacokinetics of vincristine, including the effects of age, to assist optimal dosing in this population. Methods 206 patients (0.04–33.9 years; 25 patients < 1 years), receiving vincristine, with 1297 plasma concentrations were included. Semi-mechanistic population pharmacokinetic analyses were performed using non-linear mixed effects modelling. Results A three-compartment model, with one saturable compartment resembling saturable binding to β-tubulin and thus, saturable distribution, best described vincristine pharmacokinetics. Body weight and age were covariates significantly influencing the maximal binding capacity to β-tubulin, which increased with increasing body weight and decreased with increasing age. Vincristine clearance (CL) was estimated as 30.6 L/h (95% confidence interval (CI) 27.6–33.0), intercompartmental CL (Q) as 63.2 L/h (95%CI 57.2–70.1), volume of distribution of the central compartment as 5.39 L (95%CI 4.23–6.46) and of the peripheral compartment as 400 L (95%CI 357–463) (all parameters correspond to a patient of 70 kg). The maximal binding capacity was 0.525 mg (95%CI 0.479–0.602) (for an 18 year old patient of 70 kg), with a high association rate constant, fixed at 1300 /h and a dissociation constant of 11.5 /h. Interpretation A decrease of vincristine β-tubulin binding capacity with increasing age suggests that young children tolerate higher doses of vincristine.

Changes in Electroencephalogram Indicators in Patients in the Somatogenic Phase of Acute Poisoning with Opioid Receptor Agonists - A. Yu. Mikhailov; I. Yu. Berezina; L. I. Sumsky; Yu.M. Scheidegger; T. A. Goretskaya; Yu.L. Arzumanov (Neuroscience and Behavioral Physiology, 2022)

Features of the Humoral Response to Infection, Vaccination, and Revaccination during COVID-19 - S. Yu. Kombarova; A. V. Aleshkin; L. I. Novikova; S. S. Bochkareva; A. M. Zatevalov; E. R. Mekhtiev; T. E. Mizaeva; A. A. Basov; O. Yu. Borisova; E. I. Likhanskaya; E. A. Voropaeva; Yu. N. Urban; et al. (Bulletin of Experimental Biology and Medicine, 2022)

Functional State of Various Types of Regenerative-Competent Neural Tissue Cells in β-Amyloid-Induced Neurodegeneration - G. N. Zyuz’kov; L. A. Miroshnichenko; A. V. Chaikovsky; L. Yu. Kotlovskaya (Bulletin of Experimental Biology and Medicine, 2022)

Suppression of the Antioxidant System and PI3K/Akt/mTOR Signaling Pathway in Cisplatin-Resistant Cancer Cells by Quercetin - A. A. Sh. Hasan; E. V. Kalinina; V. V. Tatarskiy; Yu. L. Volodina; А. S. Petrova; M. D. Novichkova; D. D. Zhdanov; A. A. Shtil (Bulletin of Experimental Biology and Medicine, 2022)

Acanthopagrus oconnorae , a new species of seabream (Sparidae) from the Red Sea - Lucía Pombo‐Ayora; Viktor N. Peinemann; Collin T. Williams; Song He; Yu Jia Lin; Yukio Iwatsuki; Donal D. C. Bradley; Michael L. Berumen (Journal of Fish Biology, 2022)
A new species of sparid fish, Acanthopagrus oconnorae , is described based on 11 specimens collected in the shallow (0–1 m depth) mangrove‐adjacent sandflats of Thuwal, Saudi Arabia. The new species is distinguished from its congeners by the following combination of characters: second anal‐fin spine 12.8%–16.6% of standard length (SL); 3½ scale rows between the fifth dorsal‐fin spine and lateral line; suborbital width 5.7%–6.7% of SL; eyes positioned at the anterior edge of the head, often forming a weakly convex break in an otherwise gently curved head profile, when viewed laterally; caudal fin light yellow with black posterior margin (approximately half of fin); anal fin dusky grey, with posterior one‐fifth of the fin light yellow; black streaks on inter‐radial membranes of anal fin absent. The most similar species to A. oconnorae is Acanthopagrus vagus , which differs by the presence of a w‐shaped anterior edge of the scaled predorsal area, a more acute snout and black streaks on the inter‐radial membranes of the anal fin. Phylogenetic placement and species delimitation of A. oconnorae are discussed based on COI, CytB and 16S sequences. It is hypothesized that ecology and behaviour explain how this species avoided detection despite its likely occurrence in coastal areas of the Red Sea with historically high fishing pressure.

Genome of elegance coral Catalaphyllia jardinei (Euphylliidae) - Yifei Yu; Wenyan Nong; Wai Lok So; Yichun Xie; Ho Yin Yip; Jasmine Haimovitz; Thomas Swale; David M. Baker; William G. Bendena; Ting Fung Chan; Apple P. Y. Chui; Kwok Fai Lau; et al. (Frontiers in Marine Science, 2022)
Coral reefs are under stress throughout the world. To better understand the molecular mechanisms underlying coral biology and their genomic evolution, here we sequenced the genome and transcriptomes of elegance coral Catalaphyllia jardinei (Euphylliidae). This monotypic genus stony coral is widespread but rare, being found across the Indo-West Pacific, from the northern Indian Ocean, Australia, Philippines, to the South China Sea. Due to its popularity among aquarium hobbyists, it is an overexploited species collected in large quantities from the wild for aquarium trade. The assembled genome is ~ 651.3 Mb in total length and of high physical contiguity with a scaffold N50 size of 28.9 Mb. The gene copy numbers of abiotic stress regulator (heat shock protein family genes) and neuropeptides (GLWamide, GRFamide, PRGamide and HIRamide) are similar to other sequenced anthozoans, and we have also identified the first set of sesquiterpenoid biosynthetic pathway genes in coral. Sequencing of small RNAs allows us to identify 35 microRNAs in C. jardinei and update the number of conserved microRNAs in cnidarians. This study established a foundation for further investigation into the roles of sesquiterpenoids and microRNAs in development of coral and understand their responses to climate change. Due to the easiness to culture C. jardinei in reef tanks and the established resources in this study, we propose this species be adopted as a new laboratory model in environmental and ecological experiments aiming to understand coral biology and responses to environmental stressors.

Brain Damage in Sleep-Disordered Breathing: The Role of the Glia (clinical aspects) - I. A. Filchenko; L. S. Korostovtseva; M. V. Bochkarev; Yu. V. Sviryaev (Neuroscience and Behavioral Physiology, 2022)

Two new species of Amanita section Amanita from Central China - Yu-Ting Su; Qing Cai; Wei-Qiang Qin; Yang-Yang Cui; Zuo-Hong Chen; Zhu L. Yang (Mycological Progress, 2022)

A fungal mycelium elicitor efficiently improved ginsenoside synthesis during adventitious root culture of Panax ginseng - X. L. An; Y. Yu; M. Z. Fan; X. H. Wu; X. F. Li; X. C. Piao; M. L. Lian (Journal of Plant Biochemistry and Biotechnology, 2022)

Dissecting the role of cell signaling versus CD8+ T cell modulation in propranolol antitumor activity - Wei Li; Jielin Wan; Cuiyu Chen; Chengfang Zhou; Ping Liao; Qian Hu; Jiali Hu; Yang Wang; Yu Zhang; Cong Peng; Yuanfei Huang; Weihua Huang; et al. (Journal of Molecular Medicine, 2022)

Autophagy in Neurons of the Prefrontal Cortex and Hippocampus of Rats after Trimethyltin Chloride Intoxication - I. B. Mikheeva; E. V. Pershina; I. Yu. Chernomorets; N. S. Zhuikova; L. L. Pavlik; V. I. Arkhipov (Bulletin of Experimental Biology and Medicine, 2022)

Modeling of Benign Prostatic Hyperplasia in Rats with a High Dose of Testosterone - I. V. Sorokina; N. A. Zhukova; Yu. V. Meshkova; D. S. Baev; T. G. Tolstikova; M. A. Bakarev; E. L. Lushnikova (Bulletin of Experimental Biology and Medicine, 2022)

Psychopharmacological Effects of Stimulation of the Functions of Neural Stem Cells by STAT3 Inhibitor under Conditions of Modeled Ethanol-Induced Encephalopathy - G. N. Zyuz’kov; V. V. Zhdanov; L. A. Miroshnichenko; T. Yu. Polyakova; L. A. Stavrova; E. V. Simanina; M. Yu. Minakova; V. I. Agafonov; A. A. Churin (Bulletin of Experimental Biology and Medicine, 2022)

Parameters of Hemodynamic Allostasis in Patients of Various Age Groups with Essential Arterial Hypertension - T. Yu. Zotova; A. A. Lukanina; M. L. Blagonravov (Bulletin of Experimental Biology and Medicine, 2022)

Correction to: Specific Antibodies to the Fragments of Meningococcal IgA1 Protease during the Formation of Immunity to Bacterial Infections - O. V. Kotel’nikova; Yu. A. Prokopenko; A. A. Zinchenko; O. A. Razgulyaeva; E. A. Nokel’; D. M. Karlinsky; L. S. Zhigis; L. D. Rumsh (Bulletin of Experimental Biology and Medicine, 2022)

A Device for Activating Repair Processes Using Low-Temperature Plasma Discharges in Patients with Bedsores: Optimization of Parameters and Assessment of Efficacy - S. V. Belov; S. V. Gudkov; Yu. K. Danyleiko; V. I. Lukanin; A. B. Egorov; E. L. Altukhov; M. V. Petrova; A. A. Yakovlev; E. G. Osmanov; A. M. Shulutko; E. A. Kogan; O. V. Kyt’ko; et al. (Biomedical Engineering, 2022)

Using Features of Ultrasound for the Diagnosis and Observation of Patients with Hearing Impairment - A. G. Gudkov; V. Yu. Leushin; A. I. Kryukov; N. L. Kunel’skaya; S. V. Agasieva; I. A. Sidorov; V. V. Mishchenko (Biomedical Engineering, 2022)

GeoSoilEnviroCARS (Sector 13) at the Advanced Photon Source: a comprehensive synchrotron radiation facility for Earth science research at ambient and extreme conditions - S. R. Sutton; M. L. Rivers; S. Chariton; P. J. Eng; A. Lanzirotti; M. Newville; T. Officer; V. B. Prakapenka; Y. J. Ryu; J. E. Stubbs; S. Tkachev; Y. Wang; et al. (Physics and Chemistry of Minerals, 2022)

The Role of MARK ERK1/2 and p38 in Regulation of Functions of Neural Stem Cells and Neuroglia under Conditions of β-Amyloid-Induced Neurodegeneration - G. N. Zyuz’kov; L. A. Miroshnichenko; A. V. Chaikovsky; L. Yu. Kotlovskaya (Bulletin of Experimental Biology and Medicine, 2022)

The Role of JAKs and STAT3 in Regulation of Regenerative-Competent Cells of the Nervous Tissue in β-Amyloid-Induced Neurodegeneration - G. N. Zyuz’kov; L. A. Miroshnichenko; L. Yu. Kotlovskaya; A.V. Chaikovsky (Bulletin of Experimental Biology and Medicine, 2022)

Specific Antibodies to the Fragments of Meningococcal IgA1 Protease during the Formation of Immunity to Bacterial Infections - O. V. Kotel’nikova; Yu. A. Prokopenko; A. A. Zinchenko; O. A. Razgulyaeva; E. A. Nokel’; D. M. Karlinsky; L. S. Zhigis; L. D. Rumsh (Bulletin of Experimental Biology and Medicine, 2022)

Research progress in structural and nutritional characterization and technologically processing impact on cool-season adapted oat and barley cereal kernels with wet chemistry and advanced vibrational molecular spectroscopy - M. R. Tosta; L. L. Prates; X. Feng; M. E. Rodríguez-Espinosa; H. Zhang; W. Zhang; Peiqiang Yu (Critical Reviews in Food Science and Nutrition, 2022)

Richness, not evenness, varies across water availability gradients in grassy biomes on five continents - Melinda D. Smith; Sally E. Koerner; Meghan L. Avolio; Kimberly J. Komatsu; Stephanie Eby; Elisabeth J. Forrestel; Scott L. Collins; Kevin R. Wilcox; Rodrigo Ahumada; John W. Morgan; Gabriel Oliva; Gastón R. Oñatibia; et al. (Oecologia, 2022)

Brain Damage in Sleep-Disordered Breathing: The Role of the Glia - I. A. Filchenko; L. S. Korostovtseva; M. V. Bochkarev; Yu. V. Sviryaev (Neuroscience and Behavioral Physiology, 2022)

Suppression of PI3K/Akt/mTOR Signaling Pathway and Antioxidant System and Reversal of Cancer Cells Resistance to Cisplatin under the Effect of Curcumin - E. V. Kalinina; A. A. Sh. Hasan; V. V. Tatarskiy; Yu. L. Volodina; А. S. Petrova; M. D. Novichkova; D. D. Zhdanov; N. K. Nurmuradov; N. N. Chernov; A. A. Shtil (Bulletin of Experimental Biology and Medicine, 2022)

Chronic Effects of Modeled Myocardial Infarction, Thoracic Trauma, and Denervation of Hind Limb on Rheographic Parameters of Rat Femoral Arteries In Situ - L. N. Tikhomirova; M. N. Karpova; N. Yu. Klishina; L. V. Kuznetsova; M. L. Kukushkin; A. D. Makarov; S. V. Revenko; I. A. Tarakanov (Bulletin of Experimental Biology and Medicine, 2022)

Prediction of Safety Indicators for Donor Blood and Its Components in a Statistically Managed Technological Process Based on Bayesian Inversion - N. A. Vetrova; V. N. Lemondzhava; A. A. Filyaev; A. G. Gudkov; V. D. Shashurin; V. Yu. Leushin; S. V. Sidorkevich; A. D. Kas’yanov; E. N. Gorlacheva; L. A. Luneva (Biomedical Engineering, 2022)

Hydrated Iron Oxide Embedded to Natural Zeolite: Effect of Nanoparticles and Microparticles on Sorption Properties of Composites - Yu. S. Dzyazko; L. M. Rozhdestvenska; K. O. Kudelko; I. V. Fedina; L. M. Ponomaryova; G. M. Nikovska; O. G. Dzyazko (Water, Air, & Soil Pollution, 2022)

Hearing and Dementia: Is There a Connection? - N. L. Kunelskaya; Z. O. Zaoeva; Yu. V. Levina; Ya. Yu. Nikitkina (Neuroscience and Behavioral Physiology, 2022)

A20 attenuates pyroptosis and apoptosis in nucleus pulposus cells via promoting mitophagy and stabilizing mitochondrial dynamics - Xin Peng; Cong Zhang; Zhi-Min Zhou; Kun Wang; Jia-Wei Gao; Zhan-Yang Qian; Jun-Ping Bao; Hang-Yu Ji; V. L. F. Cabral; Xiao-Tao Wu (Inflammation Research, 2022)

Prediction of disability-free survival in healthy older people - Johannes Tobias Neumann; Le T. P. Thao; Anne M. Murray; Emily Callander; Prudence R. Carr; Mark R. Nelson; Rory Wolfe; Robyn L. Woods; Christopher M. Reid; Raj C. Shah; Anne B. Newman; Jeff D. Williamson; et al. (GeroScience, 2022)
Prolonging survival in good health is a fundamental societal goal. However, the leading determinants of disability-free survival in healthy older people have not been well established. Data from ASPREE, a bi-national placebo-controlled trial of aspirin with 4.7 years median follow-up, was analysed. At enrolment, participants were healthy and without prior cardiovascular events, dementia or persistent physical disability. Disability-free survival outcome was defined as absence of dementia, persistent disability or death. Selection of potential predictors from amongst 25 biomedical, psychosocial and lifestyle variables including recognized geriatric risk factors, utilizing a machine-learning approach. Separate models were developed for men and women. The selected predictors were evaluated in a multivariable Cox proportional hazards model and validated internally by bootstrapping. We included 19,114 Australian and US participants aged ≥65 years (median 74 years, IQR 71.6–77.7). Common predictors of a worse prognosis in both sexes included higher age, lower Modified Mini-Mental State Examination score, lower gait speed, lower grip strength and abnormal (low or elevated) body mass index. Additional risk factors for men included current smoking, and abnormal eGFR. In women, diabetes and depression were additional predictors. The biased-corrected areas under the receiver operating characteristic curves for the final prognostic models at 5 years were 0.72 for men and 0.75 for women. Final models showed good calibration between the observed and predicted risks. We developed a prediction model in which age, cognitive function and gait speed were the strongest predictors of disability-free survival in healthy older people. Trial registration Clinicaltrials.gov (NCT01038583)

Prediction of EVT6-NTRK3-Dependent Papillary Thyroid Cancer Using Minor Expression Profile - A. A. Kechin; A. A. Ivanov; A. E. Kel; A. S. Kalmykov; I. P. Oskorbin; U. A. Boyarskikh; E. A. Kharpov; S. Yu. Bakharev; N. A. Oskina; O. V. Samuilenkova; I. V. Vikhlyanov; N. E. Kushlinskii; et al. (Bulletin of Experimental Biology and Medicine, 2022)

Search for New Target Genes of MicroRNA for Differential Diagnosis of Benign and Malignant Neoplasms of the Thyroid Gland by In Silico Methods - V. V. Kononchuk; E. V. Kopeikina; T. S. Kalinina; O. V. Saik; E. Yu. Alekseenok; M. K. Kolyagina; V. A. Matashova; S. P. Shevchenko; L. F. Gulyaeva; N. E. Kushlinskii (Bulletin of Experimental Biology and Medicine, 2022)

Pharmacokinetic Parameters of Oral Pegylated IFN-λ1 - E. Yu. Sherstoboev; L. A. Oleinik; V. V. Zhdanov; N. A. Kikhtenko; P. G. Madonov (Bulletin of Experimental Biology and Medicine, 2022)

Postpartum Involution of Mouse Myometrium in Acute CCl4-Induced Hepatosis and Its Correction with Immobilized Hyaluronidase - A. P. Nadeev; P. G. Madonov; E. V. Porotnikova; K. A. Koshlich; A. V. Kuznetsov; E. V. Ovsyanko; L. Yu. Kostina; D. Ya. Yakuba (Bulletin of Experimental Biology and Medicine, 2022)

The Peptide ACTH4–7-PGP Corrects Behavior and Corticosterone Levels in Rats in Chronic Stress - A. O. Vorvul; I. I. Bobyntsev; M. V. Svishcheva; O. A. Medvedeva; A. Yu. Mukhina; L. A. Andreeva (Neuroscience and Behavioral Physiology, 2022)

Low-field nuclear magnetic resonance detection of changes in the water distribution in citric acid biosludge during dewatering - Y. F. Liu; L. M. Dong; G. N. Cui; X. Y. Hu; Z. Q. Yu; S. Liang (International Journal of Environmental Science and Technology, 2022)

Waste rocks from the industrial mining process: hazard metals stabilization behavior evaluating and reusing as construction materials - E. Li; H. Chen; F. Huang; L. Zhou; Z. Yu (International Journal of Environmental Science and Technology, 2022)

Molecular Structural Features that Determine the Neurotropic Activity of Thiamine Derivatives - Yu. M. Parkhomenko; A. I. Vovk; Z. S. Protasova; S. A. Chornyy; O. L. Kobzar; S. P. Stepanenko; L. I. Chekhivska (Neurophysiology, 2022)

Morphofunctional Characteristics of Erythrocytes and Blood Erythropoietin Level in Patients as Predictors of Severe Course of COVID-19 - V. V. Revin; L. A. Balykova; O. A. Radaeva; V. V. Shchapov; E. S. Revina; S. I. Pinyaev; Yu. A. Kostina; E. D. Kozlov (Bulletin of Experimental Biology and Medicine, 2022)

LINC00839 Promotes the Progression of Gastric Cancer by Sponging miR-1236-3p - J. X. An; Z. S. Ma; W. J. Yu; B. J. Xie; F. S. Zhu; Y. X. Zhou; F. L. Cao (Bulletin of Experimental Biology and Medicine, 2022)

Global maps of soil temperature - Jonas J. Lembrechts; Johan van den Hoogen; Juha Aalto; Michael B. Ashcroft; Pieter De Frenne; Julia Kemppinen; Martin Kopecký; Miska Luoto; Ilya M. D. Maclean; Thomas W. Crowther; Joseph J. Bailey; Stef Haesen; et al. (Global Change Biology, 2022)
Research in global change ecology relies heavily on global climatic grids derived from estimates of air temperature in open areas at around 2 m above the ground. These climatic grids do not reflect conditions below vegetation canopies and near the ground surface, where critical ecosystem functions occur and most terrestrial species reside. Here, we provide global maps of soil temperature and bioclimatic variables at a 1‐km 2 resolution for 0–5 and 5–15 cm soil depth. These maps were created by calculating the difference (i.e. offset) between in situ soil temperature measurements, based on time series from over 1200 1‐km 2 pixels (summarized from 8519 unique temperature sensors) across all the world's major terrestrial biomes, and coarse‐grained air temperature estimates from ERA5‐Land (an atmospheric reanalysis by the European Centre for Medium‐Range Weather Forecasts). We show that mean annual soil temperature differs markedly from the corresponding gridded air temperature, by up to 10°C (mean = 3.0 ± 2.1°C), with substantial variation across biomes and seasons. Over the year, soils in cold and/or dry biomes are substantially warmer (+3.6 ± 2.3°C) than gridded air temperature, whereas soils in warm and humid environments are on average slightly cooler (−0.7 ± 2.3°C). The observed substantial and biome‐specific offsets emphasize that the projected impacts of climate and climate change on near‐surface biodiversity and ecosystem functioning are inaccurately assessed when air rather than soil temperature is used, especially in cold environments. The global soil‐related bioclimatic variables provided here are an important step forward for any application in ecology and related disciplines. Nevertheless, we highlight the need to fill remaining geographic gaps by collecting more in situ measurements of microclimate conditions to further enhance the spatiotemporal resolution of global soil temperature products for ecological applications.

Demographic composition, not demographic diversity, predicts biomass and turnover across temperate and tropical forests - Jessica F. Needham; Daniel J. Johnson; Kristina J. Anderson‐Teixeira; Norman Bourg; Sarayudh Bunyavejchewin; Nathalie Butt; Min Cao; Dairon Cárdenas; Chia‐Hao Chang‐Yang; Yu‐Yun Chen; George Chuyong; Handanakere S. Dattaraja; et al. (Global Change Biology, 2022)
The growth and survival of individual trees determine the physical structure of a forest with important consequences for forest function. However, given the diversity of tree species and forest biomes, quantifying the multitude of demographic strategies within and across forests and the way that they translate into forest structure and function remains a significant challenge. Here, we quantify the demographic rates of 1961 tree species from temperate and tropical forests and evaluate how demographic diversity (DD) and demographic composition (DC) differ across forests, and how these differences in demography relate to species richness, aboveground biomass (AGB), and carbon residence time. We find wide variation in DD and DC across forest plots, patterns that are not explained by species richness or climate variables alone. There is no evidence that DD has an effect on either AGB or carbon residence time. Rather, the DC of forests, specifically the relative abundance of large statured species, predicted both biomass and carbon residence time. Our results demonstrate the distinct DCs of globally distributed forests, reflecting biogeography, recent history, and current plot conditions. Linking the DC of forests to resilience or vulnerability to climate change, will improve the precision and accuracy of predictions of future forest composition, structure, and function.

Multiple tectonomagmatic reactivation of the unexposed basement in the northern Siberian craton: from Paleoproterozoic orogeny to Phanerozoic kimberlite magmatism - Sergei Yu. Skuzovatov; Vladislav S. Shatsky; Qin Wang; Alexey L. Ragozin; Sergey I. Kostrovitsky (International Geology Review, 2022)

Contrasting responses of plant above and belowground biomass carbon pools to extreme drought in six grasslands spanning an aridity gradient - Md. Shahariar Jaman; Honghui Wu; Qiang Yu; Qiqi Tan; Yunlong Zhang; Quoc Khanh Dam; Taofeek O. Muraina; Chong Xu; Minghui Jing; Xiaotong Jia; Jie Wang; Nianpeng He; et al. (Plant and Soil, 2022)

Influence of KAR1 on the plant growth and development of dormant seeds by balancing different factors - A. Sami; Z. H. Zhu; T. X. Zhu; D. M. Zhang; L. H. Xiao; Y. Yu; K. J. Zhou (International Journal of Environmental Science and Technology, 2022)

Tau deposition and structural connectivity demonstrate differential association patterns with neurocognitive tests - Zack Hall; Billy Chien; Yi Zhao; Shannon L. Risacher; Andrew J. Saykin; Yu-Chien Wu; Qiuting Wen (Brain Imaging and Behavior, 2022)
Tau neurofibrillary tangles have a central role in the pathogenesis of Alzheimer’s Disease (AD). Mounting evidence indicates that the propagation of tau is assisted by brain connectivity with weakened white-matter integrity along the propagation pathways. Recent advances in tau positron emission tomography tracers and diffusion magnetic resonance imaging allow the visualization of tau pathology and white-matter connectivity of the brain in vivo. The current study aims to investigate how tau deposition and structural connectivity are associated with memory function in prodromal AD. In this study, tau accumulation and structural connectivity data from 83 individuals (57 cognitively normal participants and 26 participants with mild cognitive impairment) were associated with neurocognitive test scores. Statistical analyses were performed in 70 cortical/subcortical brain regions to determine: 1. the level of association between tau and network metrics extracted from structural connectivity and 2. the association patterns of brain memory function with tau accumulation and network metrics. The results showed that tau accumulation and network metrics were correlated in early tau deposition regions. Furthermore, tau accumulation was associated with worse performance in almost all neurocognitive tests performance evaluated in the study. In comparison, decreased network connectivity was associated with declines in the delayed memory recall in Craft Stories and Benson Figure Copy. Interaction analysis indicates that tau deposition and dysconnectivity have a synergistic effect on the delayed Benson Figure Recall. Overall, our findings indicate that both tau deposition and structural dysconnectivity are associated with neurocognitive dysfunction. They also suggest that tau-PET may have better sensitivity to neurocognitive performance than diffusion MRI-derived measures of white-matter connectivity.

Ultrastructure and Morphological Variability of Non-Culturable Forms of Yersinia pseudotuberculosis Bacteria - L. M. Somova; E. I. Drobot; I. N. Lyapun; E. V. Pustovalov; E. V. Matosova; M. Yu. Shchelkanov (Bulletin of Experimental Biology and Medicine, 2022)

Early Diagnostic Markers and Therapeutic Targets for Experimental Breast Cancer - N. N. Ermakova; O. V. Pershina; M. A. Zhukova; A. V. Pakhomova; E. S. Pan; L. A. Sandrikina; V. A. Krupin; O. Yu. Rybalkina; A. M. Dygai; E. G. Skurikhin (Bulletin of Experimental Biology and Medicine, 2022)

Increased Yield of Residual γH2AX Foci in p53-Deficient Human Lung Carcinoma Cells Exposed to Subpicosecond Beams of Accelerated Electrons - N. Yu. Vorobyeva; N. S. Babayan; B. A. Grigoryan; A. A. Sargsyan; L. G. Khondkaryan; L. S. Apresyan; A. K. Chigasova; E. I. Yashkina; D. V. Guryev; S. M. Rodneva; A. A. Tsishnatti; Yu. A. Fedotov; et al. (Bulletin of Experimental Biology and Medicine, 2022)

The Role of JAK and STAT3 in Regulation of Secretory Function of Neuroglial Cells of Different Types in Ethanol-Induced Neurodegenerationt - G. N. Zyuz’kov; V. V. Zhdanov; L. A. Miroshnichenko; T. Yu. Polyakova; E. V. Simanina; M. G. Danilets; M. Yu. Minakova; A. A. Churin; V. I. Agafonov (Bulletin of Experimental Biology and Medicine, 2022)

Correction to: Allochromatium tepidum, sp. nov., a hot spring species of purple sulfur bacteria - Michael T. Madigan; Jill N. Absher; Joseph E. Mayers; Marie Asao; Deborah O. Jung; Kelly S. Bender; Megan L. Kempher; Mackenzie K. Hayward; Sophia A. Sanguedolce; Abigail C. Brown; Shinichi Takaichi; Ken Kurokawa; et al. (Archives of Microbiology, 2022)

Neural circuit control of innate behaviors - Wei Xiao; Zhuo-Lei Jiao; Esra Senol; Jiwei Yao; Miao Zhao; Zheng-Dong Zhao; Xiaowei Chen; Peng Cao; Yu Fu; Zhihua Gao; Wei L. Shen; Xiao-Hong Xu (Science China Life Sciences, 2022)

Safety and Pharmacokinetics of Intranasally Administered Heparin - Hannah M. Harris; Katherine L. Boyet; Hao Liu; Rohini Dwivedi; Nicole M. Ashpole; Ritesh Tandon; Gene L. Bidwell; Zhi Cheng; Lauren A. Fassero; Christian S. Yu; Vitor H. Pomin; Dipanwita Mitra; et al. (Pharmaceutical Research, 2022)

Playgrounds in City of Pushchino with Different Types of Coating as Reservoir of Antibiotic-Resistant Strains of Pseudomonas spp. - Tatiana Yu. Izmalkova; Olesya I. Sazonova; Ekaterina A. Dymova; Sergei L. Sokolov; Arslan B. Gafarov (Current Microbiology, 2022)

Metabolism of a New Dipeptide Neuroprotector in Rats - G. B. Kolyvanov; P. O. Bochkov; A. A. Litvin; R. V. Shevchenko; A. L. Podol’ko; O. Yu. Kravtsova; K. N. Kolyasnikova; V. P. Zherdev (Bulletin of Experimental Biology and Medicine, 2022)

Megakaryocytes of the Spleen in Experimental Amyloidosis and Effect of Red Wine - L. Yu. Ilyina; V. A. Kozlov; S. P. Sapozhnikov (Bulletin of Experimental Biology and Medicine, 2022)

Spectral Methods and Means of Studying the Optical Properties of Dental Materials Based on Methyl Methacrylate Resins - E. E. Maiorov; L. I. Shalamai; E. Yu. Mendosa; V. B. Lampusova; N. S. Oksas (Biomedical Engineering, 2022)

A System of Local Analyzers for Noninvasive Diagnostics of the General State of the Tissue Microcirculation System of Human Skin - V. V. Sidorov; Yu. L. Rybakov; V. M. Gukasov; G. S. Evtushenko (Biomedical Engineering, 2022)

Population Genomics, Transcriptional Response to Heat Shock, and Gut Microbiota of the Hong Kong Oyster Magallana hongkongensis - Yichun Xie; Elaine Y. Y. Huang; Wenyan Nong; Sean T. S. Law; Yifei Yu; Khan Cheung; Yiqian Li; Cheuk Fung Wong; Ho Yin Yip; Patrick W. S. Joyce; King Ming Chan; Ka Hou Chu; et al. (Journal of Marine Science and Engineering, 2022)
The Hong Kong oyster Magallana hongkongensis, previously known as Crassostrea hongkongensis, is a true oyster species native to the estuarine-coast of the Pearl River Delta in southern China. The species—with scientific, ecological, cultural, and nutritional importance—has been farmed for hundreds of years. However, there is only limited information on its genetics, stress adaptation mechanisms, and gut microbiota, restricting the sustainable production and use of oyster resources. Here, we present population structure analysis on M. hongkongensis oysters collected from Deep Bay and Lantau Island in Hong Kong, as well as transcriptome analysis on heat shock responses and the gut microbiota profile of M. hongkongensis oysters collected from Deep Bay. Single nucleotide polymorphisms (SNPs), including those on the homeobox genes and heat shock protein genes, were revealed by the whole genome resequencing. Transcriptomes of oysters incubated at 25 °C and 32 °C for 24 h were sequenced which revealed the heat-induced regulation of heat shock protein pathway genes. Furthermore, the gut microbe community was detected by 16S rRNA sequencing which identified Cyanobacteria, Proteobacteria and Spirochaetes as the most abundant phyla. This study reveals the molecular basis for the adaptation of the oyster M. hongkongensis to environmental conditions.

miR-146a-5p modulates cellular senescence and apoptosis in visceral adipose tissue of long-lived Ames dwarf mice and in cultured pre-adipocytes - Allancer D. C. Nunes; Moritz Weigl; Augusto Schneider; Sarah Noureddine; Lin Yu; Collin Lahde; Tatiana Dandolini Saccon; Kunal Mitra; Esther Beltran; Johannes Grillari; James L. Kirkland; Tamara Tchkonia; et al. (GeroScience, 2022)

Comparative Study of the Restoring Effect of Metformin, Gonadotropin, and Allosteric Agonist of Luteinizing Hormone Receptor on Spermatogenesis in Male Rats with Streptozotocin-Induced Type 2 Diabetes Mellitus - K. V. Derkach; A. A. Bakhtyukov; I. Yu. Morina; I. V. Romanova; L. V. Bayunova; A. O. Shpakov (Bulletin of Experimental Biology and Medicine, 2022)

New Carbon-Mineral Sorbent Based on Aluminum Oxide, Polydimethylsiloxane, and Single-Wall Carbon Nanotubes: Assessment of the Effect on Erythrocytes In Vitro - V. V. Nimaev; A. V. Pivkina; A. V. Shurlygina; L. N. Rachkovskaya; A. A. Smagin; E. S. Yastrebova; E. E. Rachkovskii; M. A. Korolev; V. P. Mal’tsev; A. Yu. Letyagin (Bulletin of Experimental Biology and Medicine, 2022)

Correlation between Structural Transformations in Mesenteric Lymph Nodes and the Levels MicroRNA during Polychemotherapy of Breast Cancer - A. V. Kabakov; O. V. Kazakov; A. F. Poveshchenko; A. P. Lykov; T. V. Raiter; D. N. Strunkin; L. F. Gulyaeva; V. I. Konenkov; A. Yu. Letyagin (Bulletin of Experimental Biology and Medicine, 2022)

Complete genome of the thermophilic purple sulfur Bacterium Thermochromatium tepidum compared to Allochromatium vinosum and other Chromatiaceae - W. Matthew Sattley; Wesley D. Swingley; Brad M. Burchell; Emma D. Dewey; Mackenzie K. Hayward; Tara L. Renbarger; Kathryn N. Shaffer; Lynn M. Stokes; Sonja A. Gurbani; Catrina M. Kujawa; D. Adam Nuccio; Jacob Schladweiler; et al. (Photosynthesis Research, 2022)

The Serotonin System in Mammalian Oogenesis - Yu. B. Shmukler; N. M. Alyoshina; L. A. Malchenko; D. A. Nikishin (Neuroscience and Behavioral Physiology, 2022)

Impairments to Executive Functions in Children with Dyslexia - L. S. Chutko; S. Yu. Surushkina; E. A. Yakovenko; T. I. Anisimova; M. D. Didur; S. A. Chekalova (Neuroscience and Behavioral Physiology, 2022)

Remediation performance and charring behaviors in sustainable thermal desorption of lube oil-contaminated soils - W. Yu; Y. Sang; L. He; L. Zhu (International Journal of Environmental Science and Technology, 2022)

Genome-wide analysis of mitochondrial DNA copy number reveals loci implicated in nucleotide metabolism, platelet activation, and megakaryocyte proliferation - R. J. Longchamps; S. Y. Yang; C. A. Castellani; W. Shi; J. Lane; M. L. Grove; T. M. Bartz; C. Sarnowski; C. Liu; K. Burrows; A. L. Guyatt; T. R. Gaunt; et al. (Human Genetics, 2022)
Mitochondrial DNA copy number (mtDNA-CN) measured from blood specimens is a minimally invasive marker of mitochondrial function that exhibits both inter-individual and intercellular variation. To identify genes involved in regulating mitochondrial function, we performed a genome-wide association study (GWAS) in 465,809 White individuals from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium and the UK Biobank (UKB). We identified 133 SNPs with statistically significant, independent effects associated with mtDNA-CN across 100 loci. A combination of fine-mapping, variant annotation, and co-localization analyses was used to prioritize genes within each of the 133 independent sites. Putative causal genes were enriched for known mitochondrial DNA depletion syndromes ( p = 3.09 × 10 –15 ) and the gene ontology (GO) terms for mtDNA metabolism ( p = 1.43 × 10 –8 ) and mtDNA replication ( p = 1.2 × 10 –7 ). A clustering approach leveraged pleiotropy between mtDNA-CN associated SNPs and 41 mtDNA-CN associated phenotypes to identify functional domains, revealing three distinct groups, including platelet activation, megakaryocyte proliferation, and mtDNA metabolism. Finally, using mitochondrial SNPs, we establish causal relationships between mitochondrial function and a variety of blood cell-related traits, kidney function, liver function and overall ( p = 0.044) and non-cancer mortality ( p = 6.56 × 10 –4 ).

Changes in the Levels of Neurospecific Proteins and Indices of Apoptosis in the Rat Cornea at Chronic Ethanol Consumption: Protective Effects of Thiamine Administration - O. S. Pavlova; V. L. Bilous; V. V. Korsa; S. P. Stepanenko; Yu. M. Parkhomenko; A. O. Tykhomyrov (Neurophysiology, 2022)

Effects of Boron Neutron Capture Therapy on the Growth of Subcutaneous Xenografts of Human Colorectal Adenocarcinoma SW-620 in Immunodeficient Mice - V. V. Kanygin; A. I. Kasatova; E. L. Zavjalov; I. A. Razumov; S. I. Kolesnikov; A. I. Kichigin; O. I. Solov’eva; A. R. Tsygankova; S. Yu. Taskaev; D. A. Kasatov; T. V. Sycheva; V. A. Byvaltsev (Bulletin of Experimental Biology and Medicine, 2022)

Reparative and Immunomodulatory Potential of Low-Molecular-Weight Fractions of Secondary Metabolites of Bacillus sp. - L. F. Kalenova; S. A. Petrov; Yu. G. Sukhovei (Bulletin of Experimental Biology and Medicine, 2022)

Anti-Allergic Properties of Humic Acids Isolated from Pine-Sphagnum-Cotton Sedge Peat - E. S. Trofimova; M. V. Zykova; A. A. Ligacheva; M. G. Danilets; E. Yu. Sherstoboev; L. A. Logvinova; M. V. Belousov (Bulletin of Experimental Biology and Medicine, 2022)

A Software Package Supporting Decision Making on the Safety of Thermolabile Blood Components - O. O. Varlamov; D. A. Chuvikov; V. N. Lemondzhava; A. G. Gudkov; D. V. Aladin; L. E. Adamova; V. G. Osipov; A. V. Chechetkin; V. Yu. Leushin; A. D. Kasyanov; N. A. Vetrova (Biomedical Engineering, 2022)

Allochromatium tepidum, sp. nov., a hot spring species of purple sulfur bacteria - Michael T. Madigan; Jill N. Absher; Joseph E. Mayers; Marie Asao; Deborah O. Jung; Kelly S. Bender; Megan L. Kempher; Mackenzie K. Hayward; Sophia A. Sanguedolce; Abigail C. Brown; Shinichi Takaichi; Ken Kurokawa; et al. (Archives of Microbiology, 2022)

Not out of the woods yet: Signatures of the prolonged negative genetic consequences of a population bottleneck in a rapidly re‐expanding wader, the black‐faced spoonbill Platalea minor - Shou‐Hsien Li; Yang Liu; Chia‐Fen Yeh; Yuchen Fu; Carol K. L. Yeung; Chun‐Cheng Lee; Chi‐Cheng Chiu; Tung Hui Kuo; Fang‐Tse Chan; Yu‐Chia Chen; Wen‐Ya Ko; Cheng‐Te Yao (Molecular Ecology, 2022)
The long‐term persistence of a population which has suffered a bottleneck partly depends on how historical demographic dynamics impacted its genetic diversity and the accumulation of deleterious mutations. Here we provide genomic evidence for the genetic effect of a recent population bottleneck in the endangered black‐faced spoonbill ( Platalea minor ) after its rapid population recovery. Our data suggest that the bird's effective population size, N e , had been relatively stable (7500–9000) since 22,000 years ago; however, a recent brief yet severe bottleneck ( N e = 20) which we here estimated to occur around the 1940s wiped out >99% of its historical N e in roughly three generations. Despite a >15‐fold population recovery since 1988, we found that black‐faced spoonbill population has higher levels of inbreeding (7.4 times more runs of homozygosity) than its sister species, the royal spoonbill ( P. regia ), which is not thought to have undergone a marked population contraction. Although the two spoonbills have similar levels of genome‐wide genetic diversity, our results suggest that selection on more genes was relaxed in the black‐faced spoonbill; moreover individual black‐faced spoonbills carry more putatively deleterious mutations (Grantham's score > 50), and may therefore express more deleterious phenotypic effects than royal spoonbills. Here we demonstrate the value of using genomic indices to monitor levels of genetic erosion, inbreeding and mutation load in species with conservation concerns. To mitigate the prolonged negative genetic effect of a population bottleneck, we recommend that all possible measures should be employed to maintain population growth of a threatened species.

Is a drought a drought in grasslands? Productivity responses to different types of drought - Charles J. W. Carroll; Ingrid J. Slette; Robert J. Griffin-Nolan; Lauren E. Baur; Ava M. Hoffman; Elsie M. Denton; Jesse E. Gray; Alison K. Post; Melissa K. Johnston; Qiang Yu; Scott L. Collins; Yiqi Luo; et al. (Oecologia, 2021)

Multilayer adsorption of organic dyes on coal tar-based porous carbon with ultra-high specific surface area - X. Wang; F. Huang; M. Yu; C. Zhang; F. Ding; L. Chen; H. Chen (International Journal of Environmental Science and Technology, 2021)

The Electrical Conductivity of Bone Marrow Cells Suspension Associated with Proliferative Activity and Depends on the Donor’s Age and the Functional Activity of the Liver - A. I. Bozhkov; S. L. Ohiienko; A. Yu. Bondar; V. O. Katrich; V. O. Kozheshkurt; Ye. O. Antonenko; S. S. Haiovyi; Yu. H. Kot (Cell Biochemistry and Biophysics, 2021)

Expression and Content of Protein LC3B in Gastric Cancer Tissue, Relationship with Expression of mTOR, AMPK in Gastric Cancer Tissue and HER2 and PD-L1 Status of the Tumor - L. V. Spirina; A. V. Avgustinovich; S. G. Afanas’ev; M. Yu. Volkov; I. V. Kondakova (Bulletin of Experimental Biology and Medicine, 2021)

Functional Neurological Disorders - L. S. Chutko; S. Yu. Surushkina (Neuroscience and Behavioral Physiology, 2021)

Colony-Forming Ability and Residual Foci of DNA Repair Proteins in Human Lung Fibroblasts Irradiated with Subpicosecond Beams of Accelerated Electrons - N. S. Babayan; D. V. Guryev; N. Yu. Vorobyeva; B. A. Grigoryan; G. L. Tadevosyan; L. S. Apresyan; A. K. Chigasova; E. I. Yashkina; S. M. Rodneva; A. A. Tsishnatti; Yu. A. Fedotov; N. K. Sarkisyan; et al. (Bulletin of Experimental Biology and Medicine, 2021)

Morphofunctional Properties of Corneal Stromal Cells - M. A. Surovtseva; O. V. Poveshchenko; K. Yu. Krasner; I. I. Kim; A. P. Lykov; N. A. Bondarenko; L. A. Shul’mina; A. N. Trunov; V. V. Chernykh (Bulletin of Experimental Biology and Medicine, 2021)

Relationship of Carbohydrate Metabolism and Molecular Genetic Markers in Gliomas with Different Degree of Anaplasia - L. М. Obukhova; О. N. Nikiforova; Т. V. Kopytova; N. Yu. Orlinskaya; М. М. Kontorshchikov; K. N. Kontorshchikova; I. А. Medyanik; А. S Grishin; D. D Vasina (Bulletin of Experimental Biology and Medicine, 2021)

A Device for Comprehensive Noninvasive Diagnostics of the Tissue Microcirculation System of Human Skin - V. V. Sidorov; Yu. L. Rybakov; V. M. Gukasov; G. S. Evtushenko (Biomedical Engineering, 2021)

Morphogenesis of wheat calluses treated with Azospirillum lipopolysaccharides - Oksana V. Tkachenko; Gennady L. Burygin; Nina V. Evseeva; Yulia P. Fedonenko; Larisa Yu. Matora; Yuriy V. Lobachev; Sergei Yu. Shchyogolev (Plant Cell, Tissue and Organ Culture (PCTOC), 2021)

High-Definition Transcranial Direct Current Electrical Stimulation - A. G. Poydasheva; I. S. Bakulin; D. Yu. Lagoda; E. L. Pavlova; N. A. Suponeva; M. A. Piradov (Neuroscience and Behavioral Physiology, 2021)

Development of Early Diagnosis of Parkinson’s Disease Using Premotor Symptoms and Blood Changes as Biomarkers - E. I. Gusev; E. A. Katunina; M. Yu. Martinov; V. E. Blokhin; A. L. Kalinkin; A. V. Alesenko; M. R. Nodel; E. A. Malykhina; N. V. Titova; D. A. Katunin; M. A. Shupik; U. A. Gutner; et al. (Neuroscience and Behavioral Physiology, 2021)

Rhizosphere-associated nosZII microbial community of Phragmites australis and its influence on nitrous oxide emissions in two different regions - Rui Su; Rui Huang; Jin Zeng; Dayong Zhao; Rujia He; Zhongbo Yu; Qinglong L. Wu (Journal of Soils and Sediments, 2021)

Point of Care Blood Gas and Electrolyte Analysis in Anesthetized Olive Baboons (Papio anubis) in a Field Setting - Maureen W. Kamau; James M. Hassell; Ellie L. Milnes; Lee-Ann C. Hayek; Mathew M. Mutinda; Roi Harel; Akiko Matsumoto-Oda; Jennifer H. Yu; Dawn Zimmerman; Margaret Crofoot; Suzan Murray (International Journal of Primatology, 2021)

Components of metabolic syndrome associated with lower neurocognitive performance in youth with perinatally acquired HIV and youth who are HIV-exposed uninfected - Stephanie Shiau; Wendy Yu; Denise L. Jacobson; Sharon Nichols; Elizabeth J. McFarland; Janet S. Chen; Sahera Dirajlal-Fargo; Karen Surowiec; Mitchell E. Geffner; Jennifer Jao (Journal of NeuroVirology, 2021)

Role of MAPK ERK1/2 and p38 in the Regulation of Secretory Functions of Different Populations of Neuroglia in Ethanol-Induced Neurodegeneration - G. N. Zyuz’kov; L. A. Miroshnichenko; T. Yu. Polyakova; V. V. Zhdanov; E. V. Simanina; L. A. Stavrova; A. A. Churin; T. I. Fomina (Bulletin of Experimental Biology and Medicine, 2021)

Age-Related Features of the Viscosity of Plasma and Mitochondrial Membranes of Hepatocytes in Liver Cirrhosis - E. G. Skurikhin; S. A. Afanas’ev; M. A. Zhukova; T. Yu. Rebrova; E. F. Muslimova; E. S. Pan; N. N. Ermakova; O. V. Pershina; A. V. Pakhomova; O. D. Putrova; L. A. Sandrikina; L. V. Kogai; et al. (Bulletin of Experimental Biology and Medicine, 2021)

Plant traits and soil fertility mediate productivity losses under extreme drought in C 3 grasslands - Wentao Luo; Robert J. Griffin‐Nolan; Wang Ma; Bo Liu; Xiaoan Zuo; Chong Xu; Qiang Yu; Yahuang Luo; Pierre Mariotte; Melinda D. Smith; Scott L. Collins; Alan K. Knapp; et al. (Ecology, 2021)
Extreme drought decreases aboveground net primary production (ANPP) in most grasslands, but the magnitude of ANPP reductions varies especially in C 3 ‐dominated grasslands. Because the mechanisms underlying such differential ecosystem responses to drought are not well resolved, we experimentally imposed an extreme 4‐yr drought (2015–2018) in two C 3 grasslands that differed in aridity. These sites had similar annual precipitation and dominant grass species ( Leymus chinensis ) but different annual temperatures and thus water availability. Drought treatments differentially affected these two semiarid grasslands, with ANPP of the drier site reduced more than at the wetter site. Structural equation modeling revealed that community‐weighted means for some traits modified relationships between soil moisture and ANPP, often due to intraspecific variation. Specifically, drought reduced community mean plant height at both sites, resulting in a reduction in ANPP beyond that attributable to reduced soil moisture alone. Higher community mean leaf carbon content enhanced the negative effects of drought on ANPP at the drier site, and ANPP–soil‐moisture relationships were influenced by soil C:N ratio at the wetter site. Importantly, neither species richness nor functional dispersion were significantly correlated with ANPP at either site. Overall, as expected, soil moisture was a dominant, direct driver of ANPP response to drought, but differential sensitivity to drought in these two grasslands was also related to soil fertility and plant traits.

Down-Regulation of the Ultraviolet-Sensitive Visual Pigment of the Cockroach Decreases the Masking Effect in Short-Wavelength Illumination - E. S. Novikova; I. Yu. Severina; I. L. Isavnina; M. I. Zhukovskaya (Neuroscience and Behavioral Physiology, 2021)

Analysis of Paradoxical Neurophysiological Reactions at Different Stages of the Perception of Negative Emotional Stimuli in Schizophrenia Patients - V. B. Strelets; G. I. Rodionov; M. K. Nurbekov; V. L. Ushakov; A. Yu. Arkhipov (Neuroscience and Behavioral Physiology, 2021)

miR-181a Mediates Inflammatory Gene Expression After Intracerebral Hemorrhage: An Integrated Analysis of miRNA-seq and mRNA-seq in a Swine ICH Model - Kyle B. Walsh; Kip D. Zimmerman; Xiang Zhang; Stacie L. Demel; Yu Luo; Carl D. Langefeld; Eric Wohleb; Grant Schulert; Daniel Woo; Opeolu Adeoye (Journal of Molecular Neuroscience, 2021)

Relationship of intracellular proteolysis with CAP1 and cofilin1 in non-small-cell lung cancer - E S Kolegova; G V Kakurina; E E Shashova; N V Yunusova; L V Spirina; E A Sidenko; D N Kostromitskiy; A Yu Dobrodeev; I V Kondakova (Journal of Biosciences, 2021)

Genetic analyses of gynecological disease identify genetic relationships between uterine fibroids and endometrial cancer, and a novel endometrial cancer genetic risk region at the WNT4 1p36.12 locus - Pik Fang Kho; Sally Mortlock; Frederic Amant; Daniela Annibali; Katie Ashton; John Attia; Paul L. Auer; Matthias W. Beckmann; Amanda Black; Louise Brinton; Daniel D. Buchanan; Stephen J. Chanock; et al. (Human Genetics, 2021)

IFIH1 loss-of-function variants contribute to very early-onset inflammatory bowel disease - Mara Cananzi; Elizabeth Wohler; Antonio Marzollo; Davide Colavito; Jing You; Huie Jing; Silvia Bresolin; Paola Gaio; Renan Martin; Claudia Mescoli; Sangeeta Bade; Jennifer E. Posey; et al. (Human Genetics, 2021)

Hidden diversity of Macrophomina associated with broadacre and horticultural crops in Australia - Barsha Poudel; Roger G. Shivas; Dante L. Adorada; Martin J. Barbetti; Sean L. Bithell; Lisa A. Kelly; Natalie Moore; Adam H. Sparks; Yu Pei Tan; Geoff Thomas; Joop Van Leur; Niloofar Vaghefi (European Journal of Plant Pathology, 2021)

Expression of Bax and Bcl-2 Proteins in Left-Ventricular Cardiomyocytes in Wistar-Kyoto and SHR Rats with Insulin-Dependent Diabetes Mellitus - A. P. Sklifasovskaya; M. L. Blagonravov; A. Yu. Ryabinina; M. M. Azova; V. A. Goryachev (Bulletin of Experimental Biology and Medicine, 2021)

Activation of Repair Processes in Patients with Bedsores Using Pulsed Radio-Frequency Currents - S. V. Belov; Yu. K. Danyleiko; A. B. Egorov; V. I. Lukanin; V. B. Tsvetkov; E. G. Osmanov; A. M. Shulutko; E. L. Altukhov; A. A. Yakovlev (Biomedical Engineering, 2021)

Mechanisms of Candida Resistance to Antimycotics and Promising Ways to Overcome It: The Role of Probiotics - Konstantin A. Demin; Aleksandr G. Refeld; Anna A. Bogdanova; Evgenya V. Prazdnova; Igor V. Popov; Olga Yu. Kutsevalova; Alexey M. Ermakov; Anzhelica B. Bren; Dmitry V. Rudoy; Vladimir A. Chistyakov; Richard Weeks; Michael L. Chikindas (Probiotics and Antimicrobial Proteins, 2021)

LA-ICPMS U-Pb dating reveals cassiterite inheritance in the Yazov granite, Eastern Siberia: Implications for tin mineralization - L. A. Neymark; C. S. Holm-Denoma; A. M. Larin; R. J. Moscati; Yu. V. Plotkina (Mineralium Deposita, 2021)

The Role of Intracellular Signaling Molecules in the Production of Granulocytic CSF Mononuclear Phagocytes in Stress and Cytostatic Influence - V. V. Zhdanov; L. A. Miroshnichenko; G. N. Zyuz’kov; T. Yu. Khrichkova; E. V. Udut; E. V. Simanina; E. Yu. Sherstoboev; L. A. Stavrova; V. I. Agafonov; M. G. Danilets; E. S. Trofimova; M. Yu. Minakova; et al. (Bulletin of Experimental Biology and Medicine, 2021)

Osteogenic Commitment of MSC Is Enhanced after Interaction with Umbilical Cord Blood Mononuclear Cells In Vitro - E. R. Andreeva; M. I. Ezdakova; P. I. Bobyleva; I. V. Andrianova; A. Yu. Ratushnyy; L. B. Buravkova (Bulletin of Experimental Biology and Medicine, 2021)

Mechanisms of Endothelial-to-Mesenchymal Transition Induction by Extracellular Matrix Components in Pulmonary Fibrosis - O. A. Grigorieva; M. A. Vigovskiy; U. D. Dyachkova; N. A. Basalova; N. A. Aleksandrushkina; M. A. Kulebyakina; I. L. Zaitsev; V. S. Popov; A. Yu. Efimenko (Bulletin of Experimental Biology and Medicine, 2021)

Role of H2S in Regulation of Vascular Tone in Metabolic Disorders - Yu. G. Birulina; V. V. Ivanov; E. E. Buyko; I. O. Gabitova; I. V. Kovalev; A. V. Nosarev; L. V. Smagliy; S. V. Gusakova (Bulletin of Experimental Biology and Medicine, 2021)

Size compartmentalization of energy channeling in terrestrial belowground food webs - Anton M. Potapov; Oksana L. Rozanova; Eugenia E. Semenina; Vladislav D. Leonov; Olga I. Belyakova; Varvara Yu. Bogatyreva; Maxim I. Degtyarev; Anton S. Esaulov; Anastasiya Yu. Korotkevich; Alexey A. Kudrin; Elena A. Malysheva; Yuri A. Mazei; et al. (Ecology, 2021)
Size‐structured food webs form integrated trophic systems where energy is channeled from small to large consumers. Empirical evidence suggests that size structure prevails in aquatic ecosystems, whereas in terrestrial food webs trophic position is largely independent of body size. Compartmentalization of energy channeling according to size classes of consumers was suggested as a mechanism that underpins functioning and stability of terrestrial food webs including those belowground, but their structure has not been empirically assessed across the whole size spectrum. Here we used stable isotope analysis and metabolic regressions to describe size structure and energy use in eight belowground communities with consumers spanning 12 orders of magnitude in living body mass, from protists to earthworms. We showed a negative correlation between trophic position and body mass in invertebrate communities and a remarkable nonlinearity in community metabolism and trophic positions across all size classes. Specifically, we found that the correlation between body mass and trophic level is positive in the small‐sized (protists, nematodes, arthropods below 1 μg in body mass), neutral in the medium‐sized (arthropods of 1 μg to 1 mg), and negative in the large‐sized consumers (large arthropods, earthworms), suggesting that these groups form compartments with different trophic organization. Based on this pattern, we propose a concept of belowground food webs being composed of (1) size‐structured micro‐food web driving fast energy channeling and nutrient release, for example in microbial loop; (2) arthropod macro‐food web with no clear correlation between body size and trophic level, hosting soil arthropod diversity and subsidizing aboveground predators; and (3) “trophic whales,” sequestering energy in their large bodies and restricting its propagation to higher trophic levels in belowground food webs. The three size compartments are based on a similar set of basal resources, but contribute to different ecosystem‐level functions and respond differently to variations in climate, soil characteristics and land use. We suggest that the widely used vision of resource‐based energy channeling in belowground food webs can be complemented with size‐based energy channeling, where ecosystem multifunctionality, biodiversity, and stability are supported by a balance across individual size compartments.

Chemicals from lignocellulosic biomass: A critical comparison between biochemical, microwave and thermochemical conversion methods - Iris K. M. Yu; Huihui Chen; Felix Abeln; Hadiza Auta; Jiajun Fan; Vitaly L. Budarin; James H. Clark; Sophie Parsons; Christopher J. Chuck; Shicheng Zhang; Gang Luo; Daniel C.W Tsang (Critical Reviews in Environmental Science and Technology, 2021)

Developmental Dynamics of the Functional State of the Retina in Mice with Inherited Photoreceptor Degeneration - A. A. Goriachenkov; A. Yu. Rotov; M. L. Firsov (Neuroscience and Behavioral Physiology, 2021)

Involvement of Hypothalamo-Hypophyseal-Adrenocortical System Hormones in Gastroprotection in Rats on Sensitization and Desensitization of Capsaicin-Sensitive Afferent Neurons - T. T. Podvigina; O. Yu. Morozova; O. P. Komkova; L. P. Filaretova (Neuroscience and Behavioral Physiology, 2021)

Pathogenesis of the inflammatory bowel disease in context of SARS-COV-2 infection - K. A. Dvornikova; E. Yu. Bystrova; L. P. Churilov; A. Lerner (Molecular Biology Reports, 2021)

Role of JNK and p53 in Implementation of Functions of Various Types of Regeneration-Competent Cells of the Nervous Tissue - G. N. Zyuz’kov; V. V. Zhdanov; L. A. Miroshnichenko; T. Yu. Polyakova; E. V. Simanina; L. A. Stavrova; M. G. Danilets; V. I. Agafonov; A. V. Chaikovskii (Bulletin of Experimental Biology and Medicine, 2021)

Interrelations of Cerebral Hemodynamics with Parameters of Cardiac Function and Brain Tissue in Patients with Ischemic Stroke - A. Yu. Vishnyakova; A. B. Berdalin; A. K. Nikogosova; I. L. Gubskiy; D. A. Golovin; V. G. Lelyuk (Bulletin of Experimental Biology and Medicine, 2021)

Effects of Annealing on the Fatigue of Prosthetic Heart Valve Support Frames - K. Yu. Klyshnikov; E. A. Ovcharenko; D. V. Nushtaev; L. S. Barbarash (Biomedical Engineering, 2021)

Noninvasive Measurement of the Glucose Level in Biological Media Based on Diffuse Reflectance Spectroscopy - K. V. Pozhar; M. O. Mikhailov; E. A. Polyakova; E. L. Litinskaia; Yu. E. Abolemova (Biomedical Engineering, 2021)

A Model for Recognition of Dermatoscopic Points in Images of Skin Neoplasms - V. G. Nikitaev; A. N. Pronichev; O. B. Tamrazova; V. Yu. Sergeev; M. A. Solomatin; L. S. Kruglova; V. S. Kozlov; E. A. Druzhinina (Biomedical Engineering, 2021)

A Refrigerator for Safe Storage of Blood Components and Products - A. G. Gudkov; V. Yu. Leushin; S. V. Agasieva; A. V. Chechetkin; A. D. Kasyanov; I. A. Sidorov; V. N. Lemondzhava; N. A. Vetrova; V. G. Tikhomirov; G. A. Gudkov; L. A. Luneva (Biomedical Engineering, 2021)

In vitro Inhibition of Clinical Isolates of Otitis Media Pathogens by the Probiotic Streptococcus salivarius BLIS K12 - Tzu Yu Chen; John D. F. Hale; John R. Tagg; Rohit Jain; Abigail L. Voss; Nikki Mills; Emma J. Best; Duncan S. Stevenson; Philip A. Bird; Tony Walls (Probiotics and Antimicrobial Proteins, 2021)

Novel disease resistance gene paralogs created by CRISPR/Cas9 in soy - Ervin D. Nagy; Julia L. Stevens; Neil Yu; Chris S. Hubmeier; Nona LaFaver; Megan Gillespie; Brian Gardunia; Qianshun Cheng; Steven Johnson; Audrey L. Vaughn; Miguel E. Vega-Sanchez; Mingqui Deng; et al. (Plant Cell Reports, 2021)
Key message Novel disease resistance gene paralogues are generated by targeted chromosome cleavage of tandem duplicated NBS-LRR gene complexes and subsequent DNA repair in soybean. This study demonstrates accelerated diversification of innate immunity of plants using CRISPR. Abstract Nucleotide-binding-site-leucine-rich-repeat (NBS-LRR) gene families are key components of effector-triggered immunity. They are often arranged in tandem duplicated arrays in the genome, a configuration that is conducive to recombinations that will lead to new, chimeric genes. These rearrangements have been recognized as major sources of novel disease resistance phenotypes. Targeted chromosome cleavage by CRISPR/Cas9 can conceivably induce rearrangements and thus emergence of new resistance gene paralogues. Two NBS-LRR families of soy have been selected to demonstrate this concept: a four-copy family in the Rpp1 region (Rpp1L) and a large, complex locus, Rps1 with 22 copies. Copy-number variations suggesting large-scale, CRISPR/Cas9-mediated chromosome rearrangements in the Rpp1L and Rps1 complexes were detected in up to 58.8% of progenies of primary transformants using droplet-digital PCR. Sequencing confirmed development of novel, chimeric paralogs with intact open reading frames. These novel paralogs may confer new disease resistance specificities. This method to diversify innate immunity of plants by genome editing is readily applicable to other disease resistance genes or other repetitive loci.

Robotic Restoration of Gait Function in Patients in the Early Recovery Period of Stroke - S. V. Kotov; E. V. Isakova; V. Yu. Lijdvoy; K. A. Petrushanskaya; E. V. Pismennaya; M. V. Romanova; L. Kh. Kodzokova (Neuroscience and Behavioral Physiology, 2021)

Assessment of Neuron-Specific Enolase and Brain-Derived Neurotrophic Factor Levels at Rehabilitation Stages in the Early and Late Recovery Periods of Ischemic Stroke - E. S. Koroleva; N. G. Brazovskaya; L. A. Levchuk; S. D. Kazakov; N. Yu. Romadina; V. M. Alifirova (Neuroscience and Behavioral Physiology, 2021)

Correction to: Genomic Action of Sigma-1 Receptor Chaperone Relates to Neuropathic Pain - Shao-Ming Wang; Nino Goguadze; Yuriko Kimura; Yuko Yasui; Bin Pan; Tzu-Yun Wang; Yoki Nakamura; Yu-Ting Lin; Quinn H. Hogan; Katherine L. Wilson; Tsung-Ping Su; Hsiang-en Wu (Molecular Neurobiology, 2021)
A correction to this paper has been published: 10.1007/s12035-021-02310-3

Genomic Action of Sigma-1 Receptor Chaperone Relates to Neuropathic Pain - Shao-Ming Wang; Nino Goguadze; Yuriko Kimura; Yuko Yasui; Bin Pan; Tzu-Yun Wang; Yoki Nakamura; Yu-Ting Lin; Quinn H. Hogan; Katherine L. Wilson; Tsung-Ping Su; Hsiang-en Wu (Molecular Neurobiology, 2021)
Sigma-1 receptors (Sig-1Rs) are endoplasmic reticulum (ER) chaperones implicated in neuropathic pain. Here we examine if the Sig-1R may relate to neuropathic pain at the level of dorsal root ganglia (DRG). We focus on the neuronal excitability of DRG in a “spare nerve injury” (SNI) model of neuropathic pain in rats and find that Sig-1Rs likely contribute to the genesis of DRG neuronal excitability by decreasing the protein level of voltage-gated Cav2.2 as a translational inhibitor of mRNA. Specifically, during SNI, Sig-1Rs translocate from ER to the nuclear envelope via a trafficking protein Sec61β. At the nucleus, the Sig-1R interacts with cFos and binds to the promoter of 4E-BP1, leading to an upregulation of 4E-BP1 that binds and prevents eIF4E from initiating the mRNA translation for Cav2.2. Interestingly, in Sig-1R knockout HEK cells, Cav2.2 is upregulated. In accordance with those findings, we find that intra-DRG injection of Sig-1R agonist (+)pentazocine increases frequency of action potentials via regulation of voltage-gated Ca2+ channels. Conversely, intra-DRG injection of Sig-1R antagonist BD1047 attenuates neuropathic pain. Hence, we discover that the Sig-1R chaperone causes neuropathic pain indirectly as a translational inhibitor.

Synthesis of Thresholds of Ocean Acidification Impacts on Echinoderms - Nina Bednaršek; Piero Calosi; Richard A. Feely; Richard Ambrose; Maria Byrne; Kit Yu Karen Chan; Sam Dupont; Jacqueline L. Padilla-Gamiño; John I. Spicer; Faycal Kessouri; Miranda Roethler; Martha Sutula; et al. (Frontiers in Marine Science, 2021)
Assessing the vulnerability of marine invertebrates to ocean acidification (OA) requires an understanding of critical thresholds at which developmental, physiological, and behavioral traits are affected. To identify relevant thresholds for echinoderms, we undertook a three-step data synthesis, focused on California Current Ecosystem (CCE) species. First, literature characterizing echinoderm responses to OA was compiled, creating a dataset comprised of >12,000 datapoints from 41 studies. Analysis of this data set demonstrated responses related to physiology, behavior, growth and development, and increased mortality in the larval and adult stages to low pH exposure. Second, statistical analyses were conducted on selected pathways to identify OA thresholds specific to duration, taxa, and depth-related life stage. Exposure to reduced pH led to impaired responses across a range of physiology, behavior, growth and development, and mortality endpoints for both larval and adult stages. Third, through discussions and synthesis, the expert panel identified a set of eight duration-dependent, life stage, and habitat-dependent pH thresholds and assigned each a confidence score based on quantity and agreement of evidence. The thresholds for these effects ranged within pH from 7.20 to 7.74 and duration from 7 to 30 days, all of which were characterized with either medium or low confidence. These thresholds yielded a risk range from early warning to lethal impacts, providing the foundation for consistent interpretation of OA monitoring data or numerical ocean model simulations to support climate change marine vulnerability assessments and evaluation of ocean management strategies. As a demonstration, two echinoderm thresholds were applied to simulations of a CCE numerical model to visualize the effects of current state of pH conditions on potential habitat.

Circular dichroism and resonance Raman spectroscopies of bacteriochlorophyll b-containing LH1-RC complexes - Y. Kimura; T. Yamashita; R. Seto; M. Imanishi; M. Honda; S. Nakagawa; Y. Saga; S. Takenaka; L.-J. Yu; M. T. Madigan; Z.-Y. Wang-Otomo (Photosynthesis Research, 2021)

Characteristics of Brain fMRI Responses to Motor Loads in Patients with Mild Posttraumatic Hemiparesis - G. N. Boldyreva; M. Yu. Yarets; E. V. Sharova; L. A. Zhavoronkova; S. V. Kuptsova; M. V. Chelyapina-Postnikova; E. L. Masherov; M. A. Kulikov; A. S. Smirnov; I. N. Pronin (Neuroscience and Behavioral Physiology, 2021)

Spike Activity in the Ventromedial Nucleus of Rat Hypothalamus during Aging - K. Yu. Moiseev; A. A. Spirichev; L. G. Pankrasheva; A. S. Martyusheva; A. Yu. Abramova; P. M. Maslyukov (Bulletin of Experimental Biology and Medicine, 2021)

Relationship of Molecular Genetic Tumor Marker IDH with Oxidative Status in Gliomas - L. М. Obukhova; Е. I. Murach; N. Yu. Orlinskaya; K. N. Kontorshchikova; I. А. Medyanik; А. V. Morev; М. М. Kontorshchikov; D. D. Vasina; М. А. Kuz’mina (Bulletin of Experimental Biology and Medicine, 2021)

Dynamics of Antibodies to Various Antigens of the SARS-CoV-2 Coronavirus in Patients with Confirmed COVID-19 Infection - A. V. Aleshkin; L. I. Novikova; S. S. Bochkareva; S. Yu. Kombarova; Yu. S. Lebedin; A. M. Vorob’ev; E. R. Mekhtiev; E. R. Zul’karneev; A. I. Laishevtsev; A. V. Karaulov (Bulletin of Experimental Biology and Medicine, 2021)

Evaluation of the Gastroprotective Effect of the Flavonoid Complex from Lychnis chalcedonica L. on the Models of Experimental Ulcerogenesis - S. G. Krylova; O. G. Afanas’eva; L. N. Zibareva; Yu. V. Nesterova; O. Yu. Rybalkina; T. N. Povet’eva; E. P. Zueva; G. N. Zyuzkov; N. I. Suslov (Bulletin of Experimental Biology and Medicine, 2021)

Comparative Morphological Study of the Formation of Reparative Regenerate during Skin Wound Healing in Rats under the Effect of Drugs and Bone Marrow - R. K. Chailakhyan; E. S. Mishina; A. G. Grosheva; N. N. Vorob’eva; V. I. Khachiyants; Yu. M. Inshakov; Yu. V. Gerasimov; A. I. Kuralesova; I. L. Moskvina (Bulletin of Experimental Biology and Medicine, 2021)

Age-Related Features of the Response of the Liver and Stem Cells during Modeling of Liver Cirrhosis - E. G. Skurikhin; M. A. Zhukova; E. S. Pan; N. N. Ermakova; O. V. Pershina; A. V. Pakhomova; O. D. Putrova; L. A. Sandrikina; V. A. Krupin; L. V. Kogai; T. Yu. Rebrova; S. A. Afanas’ev; et al. (Bulletin of Experimental Biology and Medicine, 2021)

Extraction of Diagnostic Information on Brain Diseases by Analyzing Wavelet Spectra of Biomedical Signals - O. S. Sushkova; A. V. Gabova; L. A. Zhavoronkova; A. V. Karabanov; I. A. Kershner; A. A. Morozov; M. V. Sinkin; R. A. Tolmacheva; L. A. Chigaleychik; Yu. V. Obukhov (Biomedical Engineering, 2021)

In Silico Ventilation Within the Dose-Volume is Predictive of Lung Function Post-radiation Therapy in Patients with Lung Cancer - Yu Dong; H. Kumar; M. Tawhai; C. Veiga; A. Szmul; D. Landau; J. McClelland; L. Lao; K. S. Burrowes (Annals of Biomedical Engineering, 2021)
Lung cancer is a leading cause of death worldwide. Radiation therapy (RT) is one method to treat this disease. A common side effect of RT for lung cancer is radiation-induced lung damage (RILD) which leads to loss of lung function. RILD often compounds pre-existing smoking-related regional lung function impairment. It is difficult to predict patient outcomes due to large variability in individual response to RT. In this study, the capability of image-based modelling of regional ventilation in lung cancer patients to predict lung function post-RT was investigated. Twenty-five patient-based models were created using CT images to define the airway geometry, size and location of tumour, and distribution of emphysema. Simulated ventilation within the 20 Gy isodose volume showed a statistically significant negative correlation with the change in forced expiratory volume in 1 s 12-months post-RT ( p = 0.001, R = − 0.61). Patients with higher simulated ventilation within the 20 Gy isodose volume had a greater loss in lung function post-RT and vice versa. This relationship was only evident with the combined impact of tumour and emphysema, with the location of the emphysema relative to the dose-volume being important. Our results suggest that model-based ventilation measures can be used in the prediction of patient lung function post-RT.

Pseudomonas simiae WCS417: star track of a model beneficial rhizobacterium - Corné M. J. Pieterse; Roeland L. Berendsen; Ronnie de Jonge; Ioannis A. Stringlis; Anja J. H. Van Dijken; Johan A. Van Pelt; Saskia C. M. Van Wees; Ke Yu; Christos Zamioudis; Peter A. H. M. Bakker (Plant and Soil, 2021)
Background Since the 1980s, numerous mutualistic Pseudomonas spp. strains have been used in studies on the biology of plant growth-promoting rhizobacteria (PGPR) and their interactions with host plants. In 1988, a strain from the Pseudomonas fluorescens group, WCS417, was isolated from lesions of wheat roots growing in a take-all disease-suppressive soil. In subsequent trials, WCS417 limited the build-up of take-all disease in field-grown wheat and significantly increased wheat yield. In 1991, WCS417 was featured in one of the first landmark studies on rhizobacteria-induced systemic resistance (ISR), in which it was shown to confer systemic immunity in carnation ( Dianthus caryophyllus ) against Fusarium wilt. The discovery that WCS417 conferred systemic immunity in the model plant species Arabidopsis thaliana in 1996 incited intensive research on the molecular mechanisms by which PGPR promote plant growth and induce broad-spectrum disease resistance in plants. Since then, the strain name appeared in over 750 studies on beneficial plant-microbe interactions. Scope In this review, we will highlight key discoveries in plant-microbe interactions research that have emerged from over 30 years of research featuring WCS417 as a model rhizobacterial strain. WCS417 was instrumental in improving our understanding of the microbial determinants that are involved in root colonization and the establishment of mutually beneficial interactions with the host plant. The model strain also provided novel insight into the molecular mechanisms of plant growth promotion and the onset and expression of rhizobacteria-ISR. More recently, WCS417 has been featured in studies on host immune evasion during root colonization, and chemical communication in the rhizosphere during root microbiome assembly. Conclusions Numerous studies on the modes of action of WCS417 have provided major conceptual advances in our understanding of how free-living mutualists colonize the rhizosphere, modulate plant immunity, and promote plant growth. The concepts may prove useful in our understanding of the molecular mechanisms involved in other binary plant-beneficial microbe interactions, and in more complex microbial community contexts, such as the root microbiome.

The effect of tree mortality on CO2 fluxes in an old-growth spruce forest - D. V. Karelin; D. G. Zamolodchikov; A. V. Shilkin; S. Yu. Popov; A. S. Kumanyaev; V. O. Lopes de Gerenyu; N. O. Tel’nova; Michael L. Gitarskiy (European Journal of Forest Research, 2021)

Glutathione and the intracellular labile heme pool - Rosemary O’Keeffe; Gladys Oluyemisi Latunde-Dada; Yu-Lin Chen; Xiaole L. Kong; Agostino Cilibrizzi; Robert C. Hider (BioMetals, 2021)
One candidate for the cytosolic labile iron pool is iron(II)glutathione. There is also a widely held opinion that an equivalent cytosolic labile heme pool exists and that this pool is important for the intracellular transfer of heme. Here we describe a study designed to characterise conjugates that form between heme and glutathione. In contrast to hydrated iron(II), heme reacts with glutathione, under aerobic conditions, to form the stable hematin–glutathione complex, which contains iron(III). Thus, glutathione is clearly not the cytosolic ligand for heme, indeed we demonstrate that the rate of heme degradation is enhanced in the presence of glutathione. We suggest that the concentration of heme in the cytosol is extremely low and that intracellular heme transfer occurs via intracellular membrane structures. Should any heme inadvertently escape into the cytosol, it would be rapidly conjugated to glutathione thereby protecting the cell from the toxic effects of heme.

Cambrian reefs in the lower Poleta Formation: a new occurrence of a thick archaeocyathan reef near Gold Point, Nevada, USA - Sara B. Pruss; Martha L. Slaymaker; Emily F. Smith; Andrey Yu. Zhuravlev; David A. Fike (Facies, 2021)

Relationship between Passive and Active Pulsations of Rat Artery as Vascular Extension of Frank—Starling Law - I. A. Tarakanov; L. N. Tikhomirova; I. Yu. Gavrilov; S. V. Revenko (Bulletin of Experimental Biology and Medicine, 2021)

Combination of Muramylpeptides from Gram-Negative Bacteria Corrects Cyclophosphamide-Induced Disorders of Hematopoiesis and Spleen Cell Composition in Mice with B16 Melanoma - M. V. Kiselevskii; N. Yu. Anisimova; S. M. Sitdikova; F. V. Donenko; V. L. L’vov; O. V. Kalyuzhin; A. Yu. Nurtazina; A. V. Karaulov (Bulletin of Experimental Biology and Medicine, 2021)

Hyperglycemia and Some Aspects of Leukocyte Activation In Vitro - E. V. Mikhalchik; V. A. Lipatova; L. Yu. Basyreva; O. M. Panasenko; S. A. Gusev; V. I. Sergienko (Bulletin of Experimental Biology and Medicine, 2021)

Effects of Succinate-Containing Preparation on Characteristics of Rat Erythrocytes in Exhaustive Swimming with a Load - N. P. Mongalev; L. Yu. Rubtsova; N. A. Vakhnina; V. D. Shadrina; O. N. Chupakhin; E. R. Bojko (Bulletin of Experimental Biology and Medicine, 2021)

EmhR is an indole‐sensing transcriptional regulator responsible for the indole‐induced antibiotic tolerance in Pseudomonas fluorescens - Jian‐Ting Han; Di‐Yin Li; Meng‐Yuan Zhang; Xiao‐Quan Yu; Xiang‐Xue Jia; Hang Xu; Xu Yan; Wen‐Juan Jia; Shaomin Niu; Megan L. Kempher; Xuanyu Tao; Yong‐Xing He (Environmental Microbiology, 2021)
Summary Indole is well known as an interspecies signalling molecule to modulate bacterial physiology; however, it is not clear how the indole signal is perceived and responded to by plant growth promoting rhizobacteria (PGPR) in the rhizosphere. Here, we demonstrated that indole enhanced the antibiotic tolerance of Pseudomonas fluorescens 2P24, a PGPR well known for its biocontrol capacity. Proteomic analysis revealed that indole influenced the expression of multiple genes including the emhABC operon encoding a major multidrug efflux pump. The expression of emhABC was regulated by a TetR‐family transcription factor EmhR, which was demonstrated to be an indole‐responsive regulator. Molecular dynamics simulation showed that indole allosterically affected the distance between the two DNA‐recognizing helices within the EmhR dimer, leading to diminished EmhR–DNA interaction. It was further revealed the EmhR ortholog in Pseudomonas syringae was also responsible for indole‐induced antibiotic tolerance, suggesting this EmhR‐dependent, indole‐induced antibiotic tolerance is likely to be conserved among Pseudomonas species. Taken together, our results elucidated the molecular mechanism of indole‐induced antibiotic tolerance in Pseudomonas species and had important implications on how rhizobacteria sense and respond to indole in the rhizosphere.

Improved Production of High-Quality Potato Seeds in Aeroponics with Plant-Growth-Promoting Rhizobacteria - Oksana V. Tkachenko; Nina V. Evseeva; Elena V. Terentyeva; Gennady L. Burygin; Alexander А. Shirokov; Andrei М. Burov; Larisa Yu. Matora; Sergei Yu. Shchyogolev (Potato Research, 2021)

Dyslexia as a Multifactorial Disorder - S. Yu. Surushkina; E. A. Yakovenko; L. S. Chutko; M. D Didur (Neuroscience and Behavioral Physiology, 2021)

Lipid and Metabolite Profiling of Serpula lacrymans Under Freezing Stress - Svetlana Viktorovna Senik; Tatiana L. Kolker; Ekaterina R. Kotlova; Dmitry Yu. Vlasov; Alexey L. Shavarda; Roman K. Puzansky; Nadezhda V. Psurtseva (Current Microbiology, 2021)

Comparative Analysis of Infarct Size Limiting Activity of δ-Opioid Receptor Agonists in Reperfused Heart In Vivo - A. V. Mukhomedzyanov; S. Yu. Tsibulnikov; A. V. Krylatov; L. N. Maslov (Bulletin of Experimental Biology and Medicine, 2021)

Comparative Analysis of Infarct Size Limiting Activity of κ-Opioid Receptor Agonists in In Vivo Reperfused Heart - A. V. Mukhomedzyanov; S. Yu. Tsibulnikov; L. N. Maslov (Bulletin of Experimental Biology and Medicine, 2021)

Study of Hematological Parameters and Morphometric Indices of Erythrocytes in Rats Exposed to Calcium Oxide Nanoparticles - M. A. Zemlyanova; N. V. Zaitseva; A. M. Ignatova; M. S. Stepankov; L. I. Toropov; Yu. V. Kol’dibekova (Bulletin of Experimental Biology and Medicine, 2021)

Pharmacological Correction of Cisplatin-Induced Hemostatic Disorders - M. V. Filonova; E. P. Fedorova; A. A. Churin; L. Yu. Kotlovskaya; M. A. Solov’ev; V. V. Udut (Bulletin of Experimental Biology and Medicine, 2021)