Cerebrospinal Fluid Extracellular Vesicles with Distinct Properties in Autoimmune Encephalitis and Herpes Simplex Encephalitis - Yongang Li; Jiachen Gu; Youbing Mao; Xijia Wang; Zongshan Li; Xiaomin Xu; Huimin Chen; Yaxing Gui (Molecular Neurobiology, 2022)
Encephalitis mediated by autoantibodies against neuronal antigens and herpes simplex encephalitis (HSE) are seemingly separate causes of encephalopathy in adults. Autoimmune encephalitis (AE) is autoimmune in origin, and herpes simplex encephalitis is infectious. The purpose of this study was to examine the role of cerebrospinal fluid (CSF) exosomes from patients with antibody-positive AE and HSE. Towards this, exosomes were isolated from CSF from 13 patients with anti- N -methyl- d -aspartate receptor (NMDAR) encephalitis, 11 patients with anti-gamma-aminobutyric acid-B (GABAB) receptor encephalitis, 9 patients with anti-leucine-rich glioma-inactivated 1 (LGI1) encephalitis, and 8 patients with anti-contactin-associated protein-like 2 (CASPR2) encephalitis, and 12 control individuals negative of antibodies against neuronal autoantigens. There were ten miRNAs highly expressed in patients with anti-NMDAR encephalitis compared to those in control subjects. Eight miRNAs were found to be lower expressed in anti-NMDAR encephalitis CSF-derived exosomes. Furthermore, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways enriched by AE differential expressed exosomic miRNAs demonstrated that AE-related exosomic miRNAs may participate as a feedback regulation in cancer development. In addition, the exosome concentration in CSF of 9 HSE patients was significantly higher compared to those from 9 HSV( −) patients. This observation was consistent with the results that exosome concentration was found to be higher in the animal model which was inoculated intranasally with HSV-1 compared to controls. Furthermore, western blot demonstrated that the subunits of NMDAR, GABA B R, and AMPAR were detected highly expressed in exosomes derived from sera of HSV-1-treated animal model compared to controls. More importantly, exosomes isolated from CSF of HSE patients contained higher expression levels of two miRNAs encoded by HSV, miR-H2-3p, and miR-H4-3p compared to those from HSV( −) patients. In summary, HSV may trigger brain autoimmunity in HSE by presentation of surface autoantigens via exosomes.

Combined numerical investigation of the Gangda paleolandslide runout and associated dam breach flood propagation in the upper Jinsha River, SE Tibetan Plateau - Yansong Zhang; Jianping Chen; Fujun Zhou; Yiding Bao; Jianhua Yan; Yiwei Zhang; Yongchao Li; Feifan Gu; Qing Wang (Landslides, 2022)

Ziprasidone suppresses pancreatic adenocarcinoma cell proliferation by targeting GOT1 to trigger glutamine metabolism reprogramming - Yueying Yang; Mengzhu Zheng; Fei Han; Lei Shang; Mingxue Li; Xiaoxia Gu; Hua Li; Lixia Chen (Journal of Molecular Medicine, 2022)

Mechanically activated calcium carbonate and zero-valent iron composites for one-step treatment of multiple pollutants - Yanhui Hu; Weijian Gu; Huimin Hu; Xuewei Li; Qiwu Zhang (Environmental Science and Pollution Research, 2022)

Effects of polystyrene microplastics on copper toxicity to the protozoan Euglena gracilis: emphasis on different evaluation methods, photosynthesis, and metal accumulation - Xiuling Li; Zhengjun Wang; Ming Bai; Zhehua Chen; Gan Gu; Xi Li; Changwei Hu; Xuezhen Zhang (Environmental Science and Pollution Research, 2022)

RPTOR methylation in the peripheral blood and breast cancer in the Chinese population - Yifei Yin; Shuifang Lei; Lixi Li; Xiaoqin Yang; Qiming Yin; Tian Xu; Wenjie Zhou; Hong Li; Wanjian Gu; Fei Ma; Rongxi Yang; Zhengdong Zhang (Genes & Genomics, 2022)

CALM1 rs3179089 polymorphism might contribute to coronary artery disease susceptibility in Chinese male: a case–control study - Jingyan Huang; Siyun Huang; Jinhong Li; Minhua Li; Lin Gong; Tongshun Li; Lian Gu (Genes & Genomics, 2022)

The stress and deformation of stone column-improved soft clay by discrete element modelling - Meixiang Gu; Jie Cui; Jie Yuan; Yang Wu; Yadong Li; Haizhao Mo (European Journal of Environmental and Civil Engineering, 2022)

New sesquiterpeniod esters form Blumea balsamifera (L.) DC. and their anti-influenza virus activity - Yan Xiong; Ping Yi; Yuhuan Li; Rongmei Gao; Junlei Chen; Zhanxing Hu; Huayong Lou; Caixia Du; Jiayu Zhang; Yu Zhang; Chunmao Yuan; Liejun Huang; et al. (Natural Product Research, 2022)

Biosynthesis of vanillin by different microorganisms: a review - Qianqian Ma; Liwen Liu; Shuo Zhao; Zhaosong Huang; Changtao Li; Shuixing Jiang; Qiang Li; Pengfei Gu (World Journal of Microbiology and Biotechnology, 2022)

Temporal Stability Analysis for the Evaluation of Spatial and Temporal Patterns of Surface Water Quality - Xiaobin Zhang; Ligang Ma; Yihang Zhu; Weidong Lou; Baoliang Xie; Li Sheng; Hao Hu; Kefeng Zheng; Qing Gu (Water Resources Management, 2022)

Conservation tillage regulates the assembly, network structure and ecological function of the soil bacterial community in black soils - Zhuxiu Liu; Haidong Gu; Aizhen Liang; Lujun Li; Qin Yao; Yanxia Xu; Junjie Liu; Jian Jin; Xiaobing Liu; Guanghua Wang (Plant and Soil, 2022)

Analysis of expression profiles and bioinformatics suggests that plasma exosomal circular RNAs may be involved in ischemic stroke in the Chinese Han population - Bingyi Xu; Xianli Huang; Yan Yan; Zhi Zhao; Jialei Yang; Lulu Zhu; Yibing Yang; Baoyun Liang; Lian Gu; Li Su (Metabolic Brain Disease, 2022)

Influence of the rs6736 Polymorphism on Ischemic Stroke Susceptibility in Han Chinese Individuals via the Disruption of miR-7–1 Binding to the C14orf119 Gene - Xiaojing Guo; Lulu Zhu; Xinyi Zhao; Xulong Wu; Jialei Yang; Jiao Huang; Lian Gu; Li Su (Journal of Molecular Neuroscience, 2022)

Discovery of a Natural Product with Potent Efficacy Against SARS-CoV-2 by Drug Screening - Daixi Li; Cheng Wang; Shaobo Wang; Aamir Mehmood; Jiang Gu; Xin Cheng; Peiqin Chen; JingFei Qiu; Jinghong Zhao; Junping Wang; Dongqing Wei (Interdisciplinary Sciences: Computational Life Sciences, 2022)

Circular RNA circ_0008934 promotes hepatocellular carcinoma growth and metastasis through modulating miR-1305/TMTC3 axis - Jia-Xi Li; Jin-Jiang Wang; Zhou-Feng Deng; Hao Zheng; Chun-Mei Yang; Ying Yuan; Cheng Yang; Fang-Fang Gu; Wei-Qi Wu; Guang-Lei Qiao; Li-Jun Ma (Human Cell, 2022)

Dissecting four correlated growth period traits using a genome-wide association study approach in soybean - Yanfei Li; Ying-hui Li; Huilong Hong; Yansong Ma; Yongzhe Gu; Zhangxiong Liu; Scott A. Jackson; Li-juan Qiu (Genetic Resources and Crop Evolution, 2022)

Same total normal forms sperm counts of males from Lhasa and Shanghai, China - Benhong Gu; Shangren Wang; Feng Liu; Yuxuan Song; Jun Li; Yongtao Ni; Min Chen; Jianlin Hu; Luobu Ouzhu; Zheng Li; Li Liu; Xia Li; et al. (Environmental Science and Pollution Research, 2022)

Neutrophil Extracellular Traps may be a Potential Target for Treating Early Brain Injury in Subarachnoid Hemorrhage - Hanhai Zeng; Xiongjie Fu; Jing Cai; Chenjun Sun; Mengyan Yu; Yucong Peng; Jianfeng Zhuang; Jingyin Chen; Huaijun Chen; Qian Yu; Chaoran Xu; Hang Zhou; et al. (Translational Stroke Research, 2022)

Phase determination of persistent heavy rainfall related to 10–30-day intraseasonal oscillation over Southeastern China - Bin Zheng; Dejun Gu; Ailan Lin; Dongdong Peng; Chunhui Li; Yanyan Huang (Theoretical and Applied Climatology, 2022)

Lessons learnt from Typhoons Fitow and In-Fa: implications for improving urban flood resilience in Asian Coastal Cities - Faith Ka Shun Chan; Xinbing Gu; Yunfei Qi; Dimple Thadani; Yongqin David Chen; Xiaohui Lu; Lei Li; James Griffiths; Fangfang Zhu; Jianfeng Li; Wendy Y. Chen (Natural Hazards, 2022)

Feasibility and usability of a mobile health tool on anticoagulation management for patients with atrial fibrillation: a pilot study - Chi Zhang; Mang-Mang Pan; Na Wang; Wei-Wei Wang; Zheng Li; Zhi-Chun Gu; Hou-Wen Lin (European Journal of Clinical Pharmacology, 2022)

The risk characteristics of heavy metals in urban soil of typical developed cities in China - Yan Li; Dike Feng; Meiying Ji; Zhanpeng Li; Ruocheng Zhang; Chenwei Gu (Environmental Monitoring and Assessment, 2022)

The synergistic benefits of β-aminobutyric acid and γ-aminobutyrate on salt and drought tolerance in cassava - Xiaowen Ma; Jinbao Gu; Qingwen Luo; Mingfu Wen; Hua Li; Zhen-Yu Wang (Plant Biotechnology Reports, 2022)

A Possible Dynamic Mechanism for Rapid Production of the Extreme Hourly Rainfall in Zhengzhou City on 20 July 2021 - Jinfang Yin; Haodong Gu; Xudong Liang; Miao Yu; Jisong Sun; Yanxin Xie; Feng Li; Chong Wu (Journal of Meteorological Research, 2022)

Geology, fluid inclusion, bitumen and isotope geochemistry of the organic-matter-rich Nanmushu lead–zinc deposit, Mayuan, the northern margin of the Yangtze platform, China - Ying Gu; Cuihua Chen; Yulong Yang; Zhijiao Song; Xiaojie Chen; Wei Jia; Xiang Lai; Hongzhi Li; Li Yin; Xiaodong Huang; Qiumin Wu (Arabian Journal of Geosciences, 2022)

Correction to: Proteasome-dependent inactivation of Akt is essential for 12-O-tetradecanoylphorbol 13-acetate-induced apoptosis in vascular smooth muscle cells - Yongna Fan; Ping Xie; Hua Zhang; Shubin Guo; Dongfeng Gu; Mingpeng She; HuiHua Li (Apoptosis, 2022)

PrupeFUL4 regulates ripening and softening of peach fruits through ethylene biosynthesis - Shaoyu Zhang; Xianju Wang; Ze Xu; Pei Shi; Meijiao Gu; Tongyang Kang; Qin Li; Dong Zhang; Caiping Zhao (Acta Physiologiae Plantarum, 2022)

Ethylene insensitive mutation alleviates cadmium-induced photosynthesis impairment in Arabidopsis plants - Qi-Yu Zhao; Chun-Xiu Gu; Yu Wang; Guang-Zhe Li; Lin Hao (Acta Physiologiae Plantarum, 2022)

Responses of Rhodotorula mucilaginosa under Pb( II ) stress: carotenoid production and budding - Zhijun Wang; Ying Zhang; Liu Jiang; Jingjing Qiu; Yanan Gao; Tingting Gu; Zhen Li (Environmental Microbiology, 2022)
Summary Rhodotorula mucilaginosa resists heavy metal (HM) stress because of its abundant extracellular polymeric substances and functional vesicles. In this study, we provided new insights into its survival strategies at both biochemical and genetic levels. After lead exposure, carotenoid biosynthesis was initiated within 24 h incubation and then increased to the maximum after 96 h of incubation. Raman analysis confirmed that carotenoids (primarily β‐carotene) were the major identifiable chemical substances on the cell surface. Moreover, the increased carotenoid production was accompanied by a rising budding rate, ~40% higher than that in the cultures without Pb. During the 96 h of incubation, the driving force for Pb accumulation was assigned to this elevated budding rate. After 96 h, biosorption was primarily attributed to the enhanced antioxidant ability of the single cells during carotenoid production. Furthermore, the yeast budding cells demonstrated an evidently heterogeneous biosorption of Pb, i.e., the rejuvenated daughters had a relatively lower Pb level than the mother cells. This resulted in the protection of the buds from Pb stress. After investigating phosphorus uptake and the RNA sequencing data, we finally confirmed two tightly correlated pathways that resist HM stress, i.e., biochemical (carotenoid production) and reproductive (healthy buds) pathways.

Estimating the added value of GRACE total water storage and uncertainty quantification in seasonal streamflow forecasting - Li Liu; Jingkai Xie; Haiting Gu; Yue-Ping Xu (Hydrological Sciences Journal, 2022)

Comparative Profiling of Survival, Growth, and Intestinal Microbial Community of Pearl Oyster Pinctada maxima Juvenile in the Industrial Farming: The Feasibility of Using Spray-Dried Microalgae Powder - Shouguo Yang; Xi Li; Hebert Ely Vasquez; Aimin Wang; Yaohua Shi; Jiaoni Li; Xingzhi Zhang; Xing Zheng; Zhifeng Gu (Frontiers in Marine Science, 2022)
Industrial farming is an alternative mode for Pinctada maxima juvenile cultivation to avoid mass mortality caused by natural disasters. Suitable and enough food is crucial for successful industrial bivalve farming. To investigate the feasibility of live microalga instead of spray-dried microalgal powder in P. maxima juvenile industrial farming, this study replaces a positive control live microalgal diet [ Isochrysis zhanjiangensis (L-iso) and Platymonas subcordiformis (L-pla)] with spray-dried I. zhanjiangensis powder (P-iso) and P. subcordiformis powder (P-pla). Continuous feeding trials (30 days) were conducted on the P. maxima juvenile (1.2008 ± 0.0009 g initial weight and 30.12 ± 0.05 mm initial shell length), under laboratory conditions. Survival, growth performance, and intestinal microbial community were studied and compared across the groups. Results showed that survival rate (SR) did not differ significantly across the groups (ranged from 84 to 86%, P > 0.05). The growth performance in spray-dried microalgal groups, including total weight (TW), shell height (SH), absolute growth rate (AGR), and relative growth rate (RGR) for SH and TW, was slightly lower than that in live microalgal groups, while the activities of pepsin (PES), amylase (AMS), and lipase (LPS) were significantly higher ( P < 0.05). The best growth performance was observed in the L-iso group, followed by the L-pla group. A 16S rRNA-based sequencing revealed that Proteobacteria was the dominant phylum in P. maxima juvenile intestinal bacterial community under controlled conditions, which accounted for 62–82% across groups. The intestinal bacteria at the genus level were more sensitive to diets, whereas Burkholderia was the dominant genus in both L-iso (66.52 ± 6.43%) and L-pla groups (54.00 ± 5.66%), while Mycoplasma , Alphaproteobacteria , and Oxyphotobacteria were in both P-iso and P-pla groups. The P-pla group got higher ACE, Chao1, and Simpson and Shannon indices ( P < 0.05). The above results suggested that the spray-dried P-iso and P-pla can serve as substitutes for live microalga in P. maxima juvenile industrial farming under controlled conditions. The finding in this study provides basic data to optimize industrial farming technology and healthy management for P. maxima juvenile.

CcpA mutants influence selective carbon source utilization by changing interactions with target genes in Bacillus licheniformis - Yupeng Zhang; Youran Li; Fengxu Xiao; Hanrong Wang; Liang Zhang; Zhongyang Ding; Sha Xu; Zhenghua Gu; Guiyang Shi (Systems Microbiology and Biomanufacturing, 2022)

A 5′ tRNA-Ala-derived small RNA regulates anti-fungal defense in plants - Hanqing Gu; Bi Lian; Yuxiang Yuan; Ci Kong; Yan Li; Chang Liu; Yijun Qi (Science China Life Sciences, 2022)

Fruit and vegetable consumption, cardiovascular disease, and all-cause mortality in China - Jun Wang; Fangchao Liu; Jianxin Li; Keyong Huang; Xueli Yang; Jichun Chen; Xiaoqing Liu; Jie Cao; Shufeng Chen; Chong Shen; Ling Yu; Fanghong Lu; et al. (Science China Life Sciences, 2022)

Organic fertilizer amendment promotes wheat resistance to herbivory and biocontrol services via bottom-up effects in agroecosystems - Shimin Gu; Myron P. Zalucki; Xingyuan Men; Jing Li; Ruixing Hou; Qingqing Zhang; Feng Ge; Fang Ouyang (Journal of Pest Science, 2022)

Seasonal variability in dissolved oxygen in the Bohai Sea, China - Yaozu Chen; Fangguo Zhai; Yanzhen Gu; Jing Cao; Cong Liu; Xingchuan Liu; Zizhou Liu; Peiliang Li (Journal of Oceanology and Limnology, 2022)

Paracoccus shandongensis sp. nov., Isolated from Activated Sludge - Xiao-Fan Gong; Fang Wang; Dong Meng; Yu-Ling Liu; Peng-Fei Gu; Xiang-Yu Fan; Zhao-Song Huang; Zong-Jun Du; Qiang Li (Current Microbiology, 2022)

Mesorhizobium xinjiangense sp. nov., isolated from rhizosphere soil of Alhagi sparsifolia - Dong Meng; Yu-Ling Liu; Jun-Jie Zhang; Peng-Fei Gu; Xiang-Yu Fan; Zhao-Song Huang; Yan Ji; Heng Meng; Zong-Jun Du; Wei-Min Li; Qiang Li (Archives of Microbiology, 2022)

Establishment and characterization of a liver cell line, ALL, derived from yellowfin sea bream, Acanthopagrus latus , and its application to fish virology - Yong Li; Peng jia; Fangzhao Yu; Wangdong Li; Can Mao; Meisheng Yi; Qunhong Gu; Kuntong Jia (Journal of Fish Diseases, 2022)
Yellowfin sea bream ( Acanthopagrus latus ) is an important economic fish, which is seriously threatened by various fish viruses. In this study, a cell line designated as ALL derived from the liver of yellowfin sea bream was developed and characterized. The cell line grew well in Dulbecco's modified Eagle's medium containing 10%–20% foetal bovine serum at 28°C. Amplification of the cytochrome B gene indicated that ALL cells originated from yellowfin sea bream. The modal chromosome number of ALL cells was 48. ALL cells were efficiently transfected with pEGFP‐N3 plasmids, indicating the potential application of ALL cells in exogenous gene manipulation studies. ALL cells were susceptive to three main fish viruses, including viral haemorrhagic septicaemia virus (VHSV), red‐spotted grouper nervous necrosis virus (RGNNV) and largemouth bass virus (LMBV). The replication of VHSV, RGNNV and LMBV in ALL cells was confirmed by quantitative real‐time polymerase chain reaction, virus titre and transmission electron microscopy assays. Moreover, ALL cells could respond to VHSV, RGNNV and LMBV infections, as indicated by the differential expression of antiviral genes involving in the innate immune response. In conclusion, the newly established ALL cell line will be an excellent in vitro platform for the study of the virus–yellowfin sea bream interaction.

Enhanced removal of aqueous chromium(VI) by KOH-activated soybean straw-based carbon - Xiaohong Guo; Weiwei Hu; Zheng Gu; Jiali Li; Zongfan Xie; Caixia Fang; Haisheng Tao (Water, Air, & Soil Pollution, 2021)

Longitudinal virological changes and underlying pathogenesis in hospitalized COVID-19 patients in Guangzhou, China - Zhengtu Li; Yinhu Li; Ruilin Sun; Shaoqiang Li; Lingdan Chen; Yangqing Zhan; Mingzhou Xie; Jiasheng Yang; Yanqun Wang; Airu Zhu; Guoping Gu; Le Yu; et al. (Science China Life Sciences, 2021)

Involvement of METTL3/m6Adenosine and TGFβ/Smad3 signaling on Tenon’s fibroblasts and in a rabbit model of glaucoma surgery - Yan Liu; Chao Gu; Xiabin Li; Tingwei Wang; Ling Yu (Journal of Molecular Histology, 2021)

Predicting circRNA-Disease Associations Based on Deep Matrix Factorization with Multi-source Fusion - Guobo Xie; Hui Chen; Yuping Sun; Guosheng Gu; Zhiyi Lin; Weiming Wang; Jianming Li (Interdisciplinary Sciences: Computational Life Sciences, 2021)

Pharmacodynamic effects of indobufen compared with aspirin in patients with coronary atherosclerosis - Mingwen Yang; Zekang Ye; Lianlian Mei; Inam Ullah; Chuchu Tan; Guoyu Wang; Qian Gu; Yi Lu; Samee Abdus; Lu Shi; Xiaoxuan Gong; Jianling Bai; et al. (European Journal of Clinical Pharmacology, 2021)

Genome editing of Corynebacterium glutamicum mediated with Cpf1 plus Ku/LigD - Fa-Yu Yang; Nan Wei; Zhi-Hao Zhang; Mi Wang; Ying-Chun Liu; Li-Fang Zhang; Feng Gu (Biotechnology Letters, 2021)

G1-like PB2 gene improves virus replication and competitive advantage of H9N2 virus - Xiuli Li; Shumiao Qiao; Ying Zhao; Min Gu; Ruyi Gao; Kaituo Liu; Zhichuang Ge; Jing Ma; Xiaoquan Wang; Jiao Hu; Shunlin Hu; Xiaowen Liu; et al. (Virus Genes, 2021)

Heterologous expression of Solanum tuberosum NAC1 gene confers enhanced tolerance to salt stress in transgenic Nicotiana benthamiana - Lu Yue; Yong Zhuang; Yuanyang Gu; Hui Li; Shengbin Tu; Xiaocheng Yang; Weizao Huang (Journal of Plant Biology, 2021)

Genetic Diversity and Population Structure of Gynaephora qinghaiensis in Yushu Prefecture, Qinghai Province Based on the Mitochondrial COI Gene - Haizhen Wang; Xin Zhong; Huafeng Lin; Shaosong Li; Jiequn Yi; Guren Zhang; Xin Liu; Li Gu (Biochemical Genetics, 2021)

LncRNA H19 rs4929984 Variant is Associated with Coronary Artery Disease Susceptibility in Han Chinese Female Population - Jiao Huang; Minhua Li; Jinhong Li; Baoyun Liang; Zhaoxia Chen; Jialei Yang; Xiaojing Guo; Siyun Huang; Lian Gu; Li Su (Biochemical Genetics, 2021)

A quadruple recombination event discovered in hepatitis E virus - Hao Shen; Shuning Liu; Min Ding; Haixia Gu; Ming Chang; Yanshuang Li; Hua Wang; Xingwen Bai; Hongxing Shen (Archives of Virology, 2021)

The test and fitting analysis of Hunan clay soil–water characteristic curve in full suction range - Gaoliang Tao; Kai Gu; Chuheng Zhong; Yangyang Chen; Da Lei; Ziyue Li (Arabian Journal of Geosciences, 2021)

Immune response of silver pomfret ( Pampus argenteus ) to Amyloodinium ocellatum infection - Youyi Zhang; Jiabao Hu; Yaya Li; Man Zhang; Kimran Jean Jacques; Weiwei Gu; Yibo Sun; Jiachu Sun; Yang Yang; Shanliang Xu; Yajun Wang; Xiaojun Yan (Journal of Fish Diseases, 2021)
Amyloodinium ocellatum (AO) infection in silver pomfret ( Pampus argenteus ) causes extensive mortality. Insufficient information exists on the molecular immune response of silver pomfret to AO infestation, so herein we simulated the process of silver pomfret being infected by AO. Translucent trophosomes were observed on the gills of AO‐infected fish. Transcriptome profiling was performed to investigate the effects of AO infection on the gill, kidney complex and spleen. Overall, 404,412,298 clean reads were obtained, assembling into 96,341 unigenes, which were annotated against public databases. In total, 2730 differentially expressed genes were detected, and few energy‐ and immune‐related genes were further assessed using RT‐qPCR. Moreover, activities of three immune‐related (SOD, AKP and ACP) and three energy‐related (PKM, LDH and GCK) enzymes were determined. AO infection activated the immune system and increased interleukin‐1 beta and immunoglobulin M heavy chain levels. Besides, the PPAR signalling pathway was highly enriched, which played a role in improving immunity and maintaining homeostasis. AO infection also caused dyspnoea, leading to extensive lactic acid accumulation, potentially contributing towards a strong immune response in the host. Our data improved our understanding regarding the immune response mechanisms through which fish coped with parasitic infections and may help prevent high fish mortality in aquaculture.

Warming reshaped the microbial hierarchical interactions - Yuqi Zhou; Baoyu Sun; Baohua Xie; Kai Feng; Zhaojing Zhang; Zheng Zhang; Shuzhen Li; Xiongfeng Du; Qi Zhang; Songsong Gu; Wen Song; Linlin Wang; et al. (Global Change Biology, 2021)
Global warming may alter microbially mediated ecosystem functions through reshaping of microbial diversity and modified microbial interactions. Here, we examined the effects of 5‐year experimental warming on different microbial hierarchical groups in a coastal nontidal soil ecosystem, including prokaryotes (i.e., bacteria and archaea), fungi, and Cercozoa, which is a widespread phylum of protists. Warming significantly altered the diversity and structure of prokaryotic and fungal communities in soil and additionally decreased the complexity of the prokaryotic network and fragmented the cercozoan network. By using the Inter‐Domain Ecological Network approach, the cross‐trophic interactions among prokaryotes, fungi, and Cercozoa were further investigated. Under warming, cercozoan–prokaryotic and fungal–prokaryotic bipartite networks were simplified, whereas the cercozoan–fungal network became slightly more complex. Despite simplification of the fungal–prokaryotic network, the strengthened synergistic interactions between saprotrophic fungi and certain prokaryotic groups, such as the Bacteroidetes, retained these phyla within the network under warming. In addition, the interactions within the fungal community were quite stable under warming conditions, which stabilized the interactions between fungi and prokaryotes or protists. Additionally, we found the microbial hierarchical interactions were affected by environmental stress (i.e., salinity and pH) and soil nutrients. Interestingly, the relevant microbial groups could respond to different soil properties under ambient conditions, whereas under warming these two groups tended to respond to similar soil properties, suggesting network hub species responded to certain environmental changes related to warming, and then transferred this response to their partners through trophic interactions. Finally, warming strengthened the network modules’ negative association with soil organic matters through some fungal hub species, which might trigger soil carbon loss in this ecosystem. Our study provides new insights into the response and feedback of microbial hierarchical interactions under warming scenario.

Climate change may interact with nitrogen fertilizer management leading to different ammonia loss in China’s croplands - Xiangrui Xu; Xiao Ouyang; Yining Gu; Kun Cheng; Pete Smith; Jianfei Sun; Yunpeng Li; Genxing Pan (Global Change Biology, 2021)
Despite research into the response of ammonia (NH 3 ) volatilization in farmland to various meteorological factors, the potential impact of future climate change on NH 3 volatilization is not fully understood. Based on a database consisting of 1063 observations across China, nonlinear NH 3 models considering crop type, meteorological, soil and management variables were established via four machine learning methods, including support vector machine, multi‐layer perceptron, gradient boosting machine and random forest (RF). The RF model had the highest R 2 of 0.76 and the lowest RMSE of 0.82 kg NH 3 ‐N ha − 1 , showing the best simulation capability. Results of model importance indicated that NH 3 volatilization was mainly controlled by total input of N fertilizer, followed by meteorological factors, human managements and soil characteristics. The NH 3 emissions of China's cereal production (paddy rice, wheat and maize) in 2018 was estimated to be 3.3 Mt NH 3 ‐N. By 2050, NH 3 volatilization will increase by 23.1−32.0% under different climate change scenarios (Representative Concentration Pathways, RCPs), and climate change will have the greatest impact on NH 3 volatilization in the Yangtze river agro‐region of China due to high warming effects. However, the potential increase in NH 3 volatilization under future climate change can be mitigated by 26.1−47.5% through various N fertilizer management optimization options.

Comparison in Growth, Feeding, and Metabolism Between a Fast-Growing Selective Strain and a Cultured Population of Pearl Oyster (Pinctada fucata martensii) - Xingzhi Zhang; Bingcong Ye; Zhifeng Gu; Meng Li; Shouguo Yang; Aimin Wang; Chunsheng Liu (Frontiers in Marine Science, 2021)
Pearl oyster ( Pinctada fucata martensii ) is the main species cultured for marine pearls in the world. A breeding program was carried out for desirable production traits, including high growth rate, and a fast-growing selective strain of pearl oysters was established. In the current study, we compared the growth characteristics between a selective strain and a cultured population of P. f. martensii in Beihai, Guangxi Province, China. Large size (SL) and small size (SS) individuals of the selective strain were selected, and the differences of physiological and metabolic indexes, such as feeding, respiration, excretion, and enzyme activities between SL and SS and cultured population (CL), were also compared. The results showed that at the age of 6 months, pearl oysters of the selective strain were 14.61% larger than CL, and the proportion of SL (30–40 mm) was 59%, which was two times higher than CL (28%). SL with a rapid growth rate had a high clearance rate (CR), and the CR of SL was about 1.8 times higher than that of CL and 5 times higher than that of SS. In addition, the activities of digestive enzymes (amylase, pepsin, and lipase) and growth-related carbonic anhydrase enzymes in SL were higher than those in the other two groups ( p < 0.05). SS with a slow growth rate had higher oxygen consumption (OCR) and ammonia excretion (AER) rates than SL and CL ( p < 0.05). Our results suggest that the rapid growth of the selective strain P. f. martensii can be attributed to increased energy intake and reduced energy consumption.

Dammarane-type saponins from Gynostemma pentaphyllum and their cytotoxicities - Wei-Ye Cui; Yulian Jin; Hui Liu; Ma-Li Zu; Xin-Fang Zhai; Ce Yang; Yu-Long Gu; Yong Cheng; Xiang-Lan Piao (Natural Product Research, 2021)

Chromone and isocoumarin derivatives from the endophytic fungus Xylomelasma sp. Samif07, and their antibacterial and antioxidant activities - Daowan Lai; Jing Li; Siji Zhao; Gan Gu; Xiao Gong; Peter Proksch; Ligang Zhou (Natural Product Research, 2021)

Research on Optimization of Parametric Propeller Based on Anti-Icing Performance and Simulation of Cutting State of Ice Propeller - Yu Lu; Chunxiao Wu; Shewen Liu; Zhuhao Gu; Wu Shao; Chuang Li (Journal of Marine Science and Engineering, 2021)
When a ship sails in an ice area, the ice could cause damage to ship hull and the propeller as well as the rudder. In the design process of an ice class propeller, the strength verification of the propeller has always been the focus of the design and research of the ice propeller. Based on the International Association of Classification Societies Unified Requirements for Polar Class (IACS Polar UR), it is required that the maximum torque from the propeller cannot exceed the required value to ensure the safety of the propeller shafting equipment. This paper investigates the hydrodynamic performance of the propeller under the condition of satisfying the propeller’s ice strength. A parametric propeller optimization design procedure was established in which the thrust coefficient and open water efficiency solved by CFD method were selected as the objective function and optimization target, the maximum ice torque was used as the optimization constraint under the condition that the ship’s shafting equipment remains unchanged, the propeller pitch, thickness, and camber at each radial direction were taken as the optimization design variables, and the optimization algorithm of SOBOL and NSGA-II was adopted. The interaction mode of propeller and ice was simulated by the method of explicit dynamics. The equivalent stress and displacement response of the blade during the cutting process of the ice propeller were calculated, monitoring the ice destruction process. The results show that the multi-objective Pareto optimal solution set of thrust coefficient and open water efficiency of the ice class propeller was formed at the design speed while maintain the maximum ice torque not exceeding the original ice torque.

Research on Main Engine Power of Transport Ship with Different Bows in Ice Area According to EEDI Regulation - Yu Lu; Zhuhao Gu; Shewen Liu; Chunxiao Wu; Wu Shao; Chuang Li (Journal of Marine Science and Engineering, 2021)
The Energy Efficiency Design Index (EEDI) has been applied to ship carbon emission standards since 2013, ice ships subject to the Finnish Swedish Ice Class Rules (FSICR) also need to meet the requirements of EEDI. In this study, the engine power requirements by EEDI at different stages for the considered ice class ships with different ice classes (1C, 1B, 1A, 1A Super) are compared with engine power requirements obtained from the resistance calculated by FSICR or Lindqvist method. Three different bow shapes for the considered ice class ships and different pack ice coverage are studied. The results from FSICR or Lindqvist formula show that 1A Super ice classes for all considered bow shapes cannot meet the requirement by EEDI at Phase 2 and 3; For 1B and 1A class, some bow shapes can meet the EEDI requirement for all stages, but some cannot; For 1C class, all bow shapes can meet the EEDI requirements for all stages. The ship main engine power requirements under different pack ice concentration are studied and compared to EEDI requirements.

Two new nor-sesquiterpenoids from Fusarium tricinctum , an endophytic fungus isolated from Ligusticum chuanxiong - Yu-Mei Cao; Da-Le Guo; Meng-Ying Jin; Lu Tan; Tian-Long Yang; Fang Deng; Yu-Cheng Gu; Xiao-Hua Li; Zhi-Xing Cao; Yun Deng (Natural Product Research, 2021)

Quantitative Analysis of Eco-economic Benefits of Urban Reclaimed Water Greening Based on Emergy Theory - Cuimei Lv; Yifan He; Wenge Zhang; Changkuan Gu; Yang Li; Denghua Yan (Water Resources Management, 2021)

Sociohydrology: An Effective Way to Reveal the Coupled Evolution of Human and Water Systems - Jiali Gu; Shikun Sun; Yubao Wang; Xiaojuan Li; Yali Yin; Jingxin Sun; Xinyu Qi (Water Resources Management, 2021)

Correction to: Inhibitory effects of aloperine on voltage-gated Na+ channels in rat ventricular myocytes - Meng-ting Li; Ya-ya Du; Fei Zhong; Jie-ru Wang; You-wei Gu; Yue Zhang; Xuan-tong Huang; Yi-zhou Deng; Zheng-xin Xu (Naunyn-Schmiedeberg's Archives of Pharmacology, 2021)

Seasonal variation of oxidative potential of water-soluble components in PM2.5 and PM1 in the Yangtze River Delta, China - Zhirao Li; Dongyang Nie; Mindong Chen; Pengxiang Ge; Zhengjiang Liu; Xiaoyun Ma; Xinlei Ge; Rui Gu (Air Quality, Atmosphere & Health, 2021)

Metabolic engineering of Escherichia coli for the production of isobutanol: a review - Pengfei Gu; Liwen Liu; Qianqian Ma; Zilong Dong; Qiang Wang; Jie Xu; Zhaosong Huang; Qiang Li (World Journal of Microbiology and Biotechnology, 2021)

Electrical capacitance estimates crop root traits best under dry conditions—a case study in cotton (Gossypium hirsutum L.) - Huijie Gu; Liantao Liu; John R. Butnor; Hongyong Sun; Xiying Zhang; Cundong Li; Xiuwei Liu (Plant and Soil, 2021)

The characterization and candidate gene isolation for a novel male-sterile mutant ms40 in maize - Xiaowei Liu; Yujing Yue; Zicheng Gu; Qiang Huang; Zijin Pan; Zhuofan Zhao; Mingmin Zheng; Zhiming Zhang; Chuan Li; Hongyang Yi; Tao Yu; Moju Cao (Plant Cell Reports, 2021)

Effects of different soil and water conservation measures on hydrological extremes and flood processes in the Yanhe River, Loess Plateau, China - ChaoJun Gu; Yongqing Zhu; Renhua Li; He Yao; Xingmin Mu (Natural Hazards, 2021)

Vascular endothelial growth factor ameliorated palmitate-induced cardiomyocyte injury via JNK pathway - Shi-ya Wang; Cao Zou; Xiao-feng Liu; Yon-jin Yan; Shun-zhon Gu; Xun Li (In Vitro Cellular & Developmental Biology - Animal, 2021)
Enhanced apoptosis of cardiomyocytes in suffering overloaded saturated fatty acids (SFAs) can result in myocardial infarction and cardiac dysfunction. The function of vascular endothelial growth factor (VEGF) in cardiomyocyte protection was not clearly described. To investigate the preservative effects of VEGF sensitization on ceramide-mediated programmed cell death of cardiomyocytes, palmitate-induced injury in H9c2 cells was established as an in vitro model. Results revealed that 0.5 mM palmitate application effectively led to debased viability and activated apoptotic factors. A significant time-dependent relation between PAL and cardiomyocyte injury was observed. The apoptosis rate was increased greatly after 16 h of treatment with 0.5 mM PAL. In addition, cell viability was restored by VEGF overexpression during treatment with 0.5 mM PAL. Reduced apoptosis rate and expression of caspase 3, Bax, and NF-κB p65 were observed in this process, while boosted Bcl-2, p-JNK/JNK expression and activity of caspase 3 were checked. However, p-ERK/ERK levels did not exhibit a significant change. These findings indicated the protective effects of VEGF in confronting the ceramide-induced cardiomyocyte apoptosis, and would devote therapeutic targets for cardiovascular safeguard in dealing with fatty acid stress.

Diversity, abundance, and distribution of anammox bacteria in shipping channel sediment of Hong Kong by analysis of DNA and RNA - Xiaowei Zhang; Han Meng; Yuchun Yang; Wensheng Lan; Weidong Wang; Paul K. S. Lam; Xiao-Yan Li; Ji-Dong Gu (Ecotoxicology, 2021)

Changes in Brain Functional Network Connectivity in Adult Moyamoya Diseases - Gaoxing Zheng; Yu Lei; Yuzhu Li; Wei Zhang; Jiabin Su; Xiaoying Qi; Liang Chen; Xin Zhang; Yuxiang Gu; Yuguo Yu; Ying Mao (Cognitive Neurodynamics, 2021)

Enhanced endogenous amino acids and energy metabolism level for cAMP biosynthesis by Arthrobacter sp. CCTCC 2013431 with citrate as cosubstrate - Zhigang Li; Baofeng Chen; Yang Gu; Hai Tan; Zhonghua Zhang; Jingling Chang (Biotechnology Letters, 2021)

Effects on the STAT3-shRNA in Non-Small-Cell Lung Cancer Therapy: Design, Induction of Apoptosis, and Conjugation with Chitosan-Based Gene Vectors - Wangwang Zhang; Yan Zhang; Zhiwen Jiang; Le Sun; Litong Wang; Zhiyang Gu; Wenya Li; Lili Guo; Xiaotong Chen; Haibin Zhang; Baoqin Han; Jing Chang (Journal of Ocean University of China, 2021)

MiR-137 inhibits the proliferation, invasion and migration of glioma via targeting to regulate EZH2 - Jingshun Gu; Juntong Wang; Aiwu You; Jun Li; Yuyan Zhang; Guomin Rao; Xuehua Ge; Kun Zhang; Xuan Liu; Dongchun Wang (Genes & Genomics, 2021)

Discovery of potential biomarkers for human atherosclerotic abdominal aortic aneurysm through untargeted metabolomics and transcriptomics - Lei Ji; Siliang Chen; Guangchao Gu; Wei Wang; Jinrui Ren; Fang Xu; Fangda Li; Jianqiang Wu; Dan Yang; Yuehong Zheng (Journal of Zhejiang University-SCIENCE B, 2021)

Protein acetylation: a novel modus of obesity regulation - Yuexia Liu; Hong Yang; Xuanchen Liu; Huihui Gu; Yizhou Li; Chao Sun (Journal of Molecular Medicine, 2021)

Mapping of geomorphic dynamic parameters for analysis of landslide hazards: A case of Yangbi river basin on the upper Lancang-Mekong of China - Zhen-kui Gu; Xin Yao; Chuang-chuang Yao; Cheng-gang Li (Journal of Mountain Science, 2021)

Mineralogy, fluid inclusions, H-O isotopes, and trace element of the Dongzigou Pb-Zn deposit in the Sangmuchang metallogenic belt, China - Ying Gu; Cuihua Chen; Yulong Yang; Xuhao Kang; Yin Li; Xiaojie Chen; Xiang Lai; Zhijiao Song; Deping Yang; Cheng Jin; Shuyue Liu (Arabian Journal of Geosciences, 2021)

Rock physics inversion based on an optimized MCMC method - Jia-Jia Zhang; Hong-Bing Li; Guang-Zhi Zhang; Yi-Peng Gu; Zhuo-Fan Liu (Applied Geophysics, 2021)

Numerical Simulation of the Ice Breaking Process for Hovercraft - Jiangjie Jin; Li Zhou; Shifeng Ding; Yingjie Gu (Journal of Marine Science and Engineering, 2021)
A hovercraft can adapt to an ice area, open water, land and other environments, owing to its unique hull structure. It also plays an important role in transporting supplies, rescuing people, breaking ice and conducting other tasks. Ice load prediction is very important for structural safety and navigation of a polar ship, especially in design of air cushion icebreakers or ice breaking platforms. In this paper, based on a simplified circumferential icebreaking pattern, the icebreaking force of the hovercraft operating on the ice sheet at low speed is simulated in a numerical way. Numerical analysis of the icebreaking process with different ice thicknesses and bending strengths are performed. The numerical results are compared with model test data in a time domain for three operating cases. By analyzing the average ice force, the errors between numerical simulation results and model test measurements are less than 30%. The present study is significant for the preliminary design of new icebreaking hovercraft and it assists the operation possibility for existing hovercraft.

Wogonin Accelerates Hematoma Clearance and Improves Neurological Outcome via the PPAR-γ Pathway After Intracerebral Hemorrhage - Jianfeng Zhuang; Yucong Peng; Chi Gu; Huihui Chen; Zheng Lin; Hang Zhou; Xiao Wu; Jianru Li; Xiaobo Yu; Yang Cao; Hanhai Zeng; Xiongjie Fu; et al. (Translational Stroke Research, 2021)

Characterization of expansin genes and their transcriptional regulation by histone modifications in strawberry - Qin Mu; Xianyang Li; Jianhua Luo; Qinwei Pan; Yi Li; Tingting Gu (Planta, 2021)

Alpha-Lipoic Acid Attenuates Cadmium- and Lead-Induced Neurotoxicity by Inhibiting Both Endoplasmic-Reticulum Stress and Activation of Fas/FasL and Mitochondrial Apoptotic Pathways in Rat Cerebral Cortex - Yan Yuan; Shi Wen Zhao; Shuang Quan Wen; Qiao Ping Zhu; Li Wang; Hui Zou; Jian Hong Gu; Xue Zhong Liu; Jian Chun Bian; Zong Ping Liu (Neurotoxicity Research, 2021)

Genipin Attenuates Tau Phosphorylation and Aβ Levels in Cellular Models of Alzheimer’s Disease - Meiting Li; Nan Cai; Liang Gu; Lijun Yao; Decheng Bi; Weishan Fang; Zhijian Lin; Yan Wu; Hong Xu; Hui Li; Zhangli Hu; Xu Xu (Molecular Neurobiology, 2021)

Synthesis and biological evaluation of novel 1,3-diphenylurea quinoxaline derivatives as potent anticancer agents - Gui-Zhen Li; Xi-Lin Ouyang; Zu-Yu Mo; Yao Gu; Xiao-Lin Cao; Li Yang; Hai-Tao Tang; Ying-Ming Pan (Medicinal Chemistry Research, 2021)

LncRNA MYCNOS promotes glioblastoma cell proliferation by regulating miR-216b/FOXM1 axis - Ping Zhao; Ting Li; Youliang Wang; Yong Wang; Qi Gu; Zhi Li (Metabolic Brain Disease, 2021)

Root Defense in Salicylic Acid-Altering Arabidopsis Plants in Responses to Cadmium Stress - Qiyu Zhao; Chunxiu Gu; Yuehang Sun; Guangzhe Li; Lin-Lin Li; Lin Hao (Journal of Plant Growth Regulation, 2021)

Metals pollution from textile production wastewater in Chinese southeastern coastal area: occurrence, source identification, and associated risk assessment - Fang Li; Zhehui Zhong; Chunjie Gu; Chensi Shen; Chunyan Ma; Yanbiao Liu; Shanshan Yin; Chenye Xu (Environmental Science and Pollution Research, 2021)

Association between population density and infection rate suggests the importance of social distancing and travel restriction in reducing the COVID-19 pandemic - Heliang Yin; Tong Sun; Lan Yao; Yan Jiao; Li Ma; Lin Lin; J Carolyn Graff; Lotfi Aleya; Arnold Postlethwaite; Weikuan Gu; Hong Chen (Environmental Science and Pollution Research, 2021)

Improving hydrogen recovery from anaerobic co-digestion of algae and food waste by high-pressure homogenisation pre-treatment - Mingxing Zhao; Jin Xu; Hanguang Xue; Chao Li; He Liu; Sai Gu; Hengfeng Miao; Wenquan Ruan (Environmental Chemistry Letters, 2021)

Abnormal white matter tracts of insula in smokers - Chao Wang; Shuyue Wang; Peiyu Huang; Zhujing Shen; Wei Qian; Xiao Luo; Kaicheng Li; Qingze Zeng; Quanquan Gu; Hualiang Yu; Yihong Yang; Minming Zhang (Brain Imaging and Behavior, 2021)

Paracoccus binzhouensis sp. nov., isolated from activated sludge - Fang Wang; Xiao-Fan Gong; Dong Meng; Yu-Ling Liu; Peng-Fei Gu; Xiang-Yu Fan; Zhao-Song Huang; Zong-Jun Du; Qiang Li (Archives of Microbiology, 2021)

Excessive admission burden of unspecified asthma attributable to air pollution: an evidence from Chengdu in China - Zhilin Yong; Li Luo; Chunyang Li; Yonghong Gu; Songze Wu (Air Quality, Atmosphere & Health, 2021)

Decreased calcium concentration interferes with life history defense strategies of Ceriodaphnia cornuta in response to fish kairomone - Jing Huang; Xiaoqing Xu; Da Li; Yunfei Sun; Lei Gu; Lu Zhang; Kai Lyu; Zhou Yang (Limnology and Oceanography, 2021)
Declining calcium in freshwater lakes has become a serious threat to aquatic organisms, which may affect the anti‐fish defense of cladocerans with high calcium demand. To evaluate the effects of low calcium on life history strategies of cladocerans for defending against fish predation, we exposed Ceriodaphnia cornuta to eight concentrations of calcium ranging from 0.5 to 50.0 mg L −1 in the absence and presence of fish kairomone, and observed the changes in body surface, recorded the key life‐history traits, and calculated the degree of its induced defense response. Results showed that, on average, low calcium (0.5, 1.0, 1.5 mg L −1 ) significantly reduced survival, maternal body size at maturation, and total offspring per female by 66.7%, 8.0%, and 48.8%, respectively, compared with those exposed to normal calcium level (10.0 mg L −1 ). At the normal calcium level, fish kairomone shortened the time to maturation, reduced maternal body size at maturation, and increased total offspring by 15.7%, 11.0%, and 29.6%, respectively, compared with those not exposed to fish kairomone. In the presence of fish kairomone, the reproduction of C. cornuta was affected by a narrower range of calcium concentrations. Calcium concentrations and fish kairomone showed a significant interaction on maternal body size at maturation, total offspring, and body size of neonates, i.e., low calcium impaired the life history defenses involved in maternal development, but enhanced the defense traits involved in reproductive performance, which indicated the diversified interference effects of decreased calcium on the life history defense strategies of C. cornuta against fish predators.

Vibrio parahaemolyticus CadC regulates acid tolerance response to enhance bacterial motility and cytotoxicity - Dan Gu; Kangru Wang; Tianyu Lu; Lingzhi Li; Xinan Jiao (Journal of Fish Diseases, 2021)
Pathogens adapted to sub‐lethal acidic conditions could increase the virulence and survival ability under lethal conditions. In the aquaculture industry, feed acidifiers have been used to increase the growth of aquatic animals. However, there is limited study on the effects of acidic condition on the virulence and survival of pathogens in aquaculture. In this study, we investigated the survival ability of Vibrio parahaemolyticus at lethal acidic pH (4.0) after adapted the bacteria to sub‐lethal acidic pH (5.5) for 1 hr. Our results indicated that the adapted strain increased the survival ability at lethal acidic pH invoked by an inorganic (HCl) or organic (citric) acid. RNA‐sequencing (RNA‐seq) results revealed that 321 genes were differentially expressed at the sub‐lethal acidic pH including cadC , cadBA and groES /g roEL relating to acid tolerance response (ATR), as well as genes relating to outer membrane, heat‐shock proteins, phosphotransferase system and flagella system. Quantitative real‐time polymerase chain reaction (qRT‐PCR) confirmed that cadC and cadBA were upregulated under sub‐lethal acidic conditions. The CadC protein could directly regulate the expression of cadBA to modulate the ATR in V . parahaemolyticus . RNA‐seq data also indicated that 113 genes in the CadC‐dependent way and 208 genes in the CadC‐independent way were differentially expressed, which were related to the regulation of ATR. Finally, the motility and cytotoxicity of the sub‐lethal acidic adapted wild type (WT) were significantly increased compared with the unadapted strain. Our results demonstrated that the dietary acidifiers may increase the virulence and survival of V . parahaemolyticus in aquaculture.

Molecular mapping of quantitative disease resistance loci for soybean partial resistance to Phytophthora sansomeana - Feng Lin; Wenlong Li; Austin G. McCoy; Xuan Gao; Paul J. Collins; Na Zhang; Zixiang Wen; Sizhe Cao; Shabir H. Wani; Cuihua Gu; Martin I. Chilvers; Dechun Wang (Theoretical and Applied Genetics, 2021)

Improving rice eating and cooking quality by coordinated expression of the major starch synthesis-related genes, SSII and Wx, in endosperm - Lichun Huang; Zhengwen Gu; Zhuanzhuan Chen; Jiawen Yu; Rui Chu; Hongyan Tan; Dongsheng Zhao; Xiaolei Fan; Changquan Zhang; Qianfeng Li; Qiaoquan Liu (Plant Molecular Biology, 2021)

Inhibitory effects of aloperine on voltage-gated Na+ channels in rat ventricular myocytes - Meng-ting Li; Ya-ya Du; Fei Zhong; Jie-ru Wang; You-wei Gu; Yue Zhang; Xuan-tong Huang; Yi-zhou Deng; Zheng-xin Xu (Naunyn-Schmiedeberg's Archives of Pharmacology, 2021)

Genetic Analysis of ZNF Protein Family Members for Early-Onset Parkinson’s Disease in Chinese Population - Chun Yu Li; Ru Wei Ou; Yong Ping Chen; Xiao Jing Gu; Qian Qian Wei; Bei Cao; Ling Yu Zhang; Yan Bing Hou; Kun Cheng Liu; Xue Ping Chen; Wei Song; Bi Zhao; et al. (Molecular Neurobiology, 2021)

Profiling of Serum Exosome MiRNA Reveals the Potential of a MiRNA Panel as Diagnostic Biomarker for Alzheimer’s Disease - Zhiwu Dong; Hongjun Gu; Qiang Guo; Shuang Liang; Jian Xue; Feng Yao; Xianglu Liu; Feifei Li; Huiling Liu; Li Sun; Kewen Zhao (Molecular Neurobiology, 2021)

Climatology and seasonal variability of satellite-derived chlorophyll a around the Shandong Peninsula - Xiukai Song; Yanzhen Gu; Fangguo Zhai; Peiliang Li; Pengxia Liu; Zizhou Liu; Wenfan Wu; Yaozu Chen; Xiangyang Jiang; Jianlong He (Journal of Oceanology and Limnology, 2021)

Population pharmacokinetics of unbound valproic acid in pediatric epilepsy patients in China: a protein binding model - Xurui Gu; Min Zhu; Changcheng Sheng; Shuran Yu; Qilin Peng; Mubai Ma; Yani Hu; Ziran Li; Zheng Jiao; Boting Zhou (European Journal of Clinical Pharmacology, 2021)

Independent and combined associations of solid-fuel use and smoking with obesity among rural Chinese adults - Mingming Pan; Jianjun Gu; Ruiying Li; Hao Chen; Xiaotian Liu; Runqi Tu; Ruoling Chen; Songcheng Yu; Zhenxing Mao; Wenqian Huo; Jian Hou; Chongjian Wang (Environmental Science and Pollution Research, 2021)

Interactive effect of water level and flushing rate on population dynamics of a harmful cyanobacterial species: Raphidiopsis raciborskii - Quehui Tang; Lamei Lei; Li Zhao; Jiguang Gu; Lijuan Xiao; Bo-Ping Han (Ecotoxicology, 2021)

Fusarium solani G6, a novel vitexin-producing endophytic fungus: characterization, yield improvement and osteoblastic proliferation activity - Pei-jia Tang; Zhi-hui Zhang; Li-li Niu; Cheng-bo Gu; Wen-yi Zheng; Hai-chao Cui; Xiao-han Yuan (Biotechnology Letters, 2021)

Local ionospheric plasma bubble revealed by BDS Geostationary Earth Orbit satellite observations - Xiaomin Luo; Yidong Lou; Shengfeng Gu; Guozhu Li; Chao Xiong; Weiwei Song; Zhengyu Zhao (GPS Solutions, 2021)

Evaluation of common genetic variants in vitamin E-related pathway genes and colorectal cancer susceptibility - Qiuyi Zhang; Yixuan Meng; Mulong Du; Shuwei Li; Junyi Xin; Shuai Ben; Zhengdong Zhang; Dongying Gu; Meilin Wang (Archives of Toxicology, 2021)

Mobile genetic elements mediate the mixotrophic evolution of novel Alicyclobacillus species for acid mine drainage adaptation - Zhenghua Liu; Zonglin Liang; Zhicheng Zhou; Liangzhi Li; Delong Meng; Xiutong Li; Jiemeng Tao; Zhen Jiang; Yabing Gu; Ye Huang; Xueduan Liu; Zhendong Yang; et al. (Environmental Microbiology, 2021)
Summary Alicyclobacillus species inhabit diverse environments and have adapted to broad ranges of pH and temperature. However, their adaptive evolutions remain elusive, especially regarding the role of mobile genetic elements (MGEs). Here, we characterized the distributions and functions of MGEs in Alicyclobacillus species across five environments, including acid mine drainage (AMD), beverages, hot springs, sediments, and soils. Nine Alicyclobacillus strains were isolated from AMD and possessed larger genome sizes and more genes than those from other environments. Four AMD strains evolved to be mixotrophic and fell into distinctive clusters in phylogenetic tree. Four types of MGEs including genomic island (GI), insertion sequence (IS), prophage, and integrative and conjugative element (ICE) were widely distributed in Alicyclobacillus species. Further, AMD strains did not possess CRISPR‐Cas systems, but had more GI, IS, and ICE, as well as more MGE‐associated genes involved in the oxidation of iron and sulfide and the resistance of heavy metal and low temperature. These findings highlight the differences in phenotypes and genotypes between strains isolated from AMD and other environments and the important role of MGEs in rapid environment niche expansions.

Construction of a Full-Length Transcriptome Resource for the Chinese Sucker (Myxocyprinus asiaticus), a Rare Protected Fish, Based on Isoform Sequencing (Iso-Seq) - Hailong Ge; Haoyu Zhang; Qingyuan Zhao; Fang Li; Haoran Gu; Siying Liu; Haibo Yang; Yun Li; Zhijian Wang (Frontiers in Marine Science, 2021)

Phenotypic and genetic dissection of cadmium accumulation in roots, nodes and grains of rice hybrids - Tengfei Liu; Liang Sun; Qiucheng Meng; Jianghui Yu; Lushui Weng; Jinjiang Li; Lihua Deng; Qihong Zhu; Xingyou Gu; Caiyan Chen; Sheng Teng; Guoying Xiao (Plant and Soil, 2021)

Incidence and Mortality of Acute Disseminated Encephalomyelitis in China: A Nationwide Population-Based Study - Yuwen Xiu; Hongqiu Gu; Xindi Li; Zixiao Li; Wei-Na Jin; Qiang Liu; Fu-Dong Shi (Neuroscience Bulletin, 2021)

Lidocaine Alleviates Neuropathic Pain and Neuroinflammation by Inhibiting HMGB1 Expression to Mediate MIP-1α/CCR1 Pathway - Mingming Li; Hao Jiang; Kuo Gu; Xuechao Sun; Jing Gu; Chunming Li; Guonian Wang (Journal of Neuroimmune Pharmacology, 2021)

Implication of excessive length of stay of asthma patient with heterogenous status attributed to air pollution - Zhilin Yong; Li Luo; Yonghong Gu; Chunyang Li (Journal of Environmental Health Science and Engineering, 2021)

PHD Finger Protein 19 Promotes Cardiac Hypertrophy via Epigenetically Regulating SIRT2 - Wei Gu; Yutong Cheng; Su Wang; Tao Sun; Zhizhong Li (Cardiovascular Toxicology, 2021)
Epigenetic regulations essentially participate in the development of cardiomyocyte hypertrophy. PHD finger protein 19 (PHF19) is a polycomb protein that controls H3K36me3 and H3K27me3. However, the roles of PHF19 in cardiac hypertrophy remain unknown. Here in this work, we observed that PHF19 promoted cardiac hypertrophy via epigenetically targeting SIRT2. In angiotensin II (Ang II)-induced cardiomyocyte hypertrophy, adenovirus-mediated knockdown of Phf19 reduced the increase in cardiomyocyte size, repressed the expression of hypertrophic marker genes Anp and Bnp , as well as inhibited protein synthesis. By contrast, Phf19 overexpression promoted Ang II-induced cardiomyocyte hypertrophy in vitro. We also knocked down Phf19 expression in mouse hearts in vivo. The results demonstrated that Phf19 knockdown reduced Ang II-induced decline in cardiac fraction shortening and ejection fraction. Phf19 knockdown also inhibited Ang II-mediated increase in heart weight, reduced cardiomyocyte size, and repressed the expression of hypertrophic marker genes in mouse hearts. Further mechanism studies showed that PHF19 suppressed the expression of SIRT2, which contributed to the function of PHF19 during cardiomyocyte hypertrophy. PHF19 bound the promoter of SIRT2 and regulated the balance between H3K27me3 and H3K36me3 to repress the expression of SIRT2 in vitro and in vivo. In human hypertrophic hearts, the overexpression of PHF19 and downregulation of SIRT2 were observed. Of importance, PHF19 expression was positively correlated with hypertrophic marker genes ANP and BNP but negatively correlated with SIRT2 in human hypertrophic hearts. Therefore, our findings demonstrated that PHF19 promoted the development of cardiac hypertrophy via epigenetically regulating SIRT2.

Technology and Concept of Wastewater Treatment: Differences Between the Rhine Basin and the Yangtze Basin - Chenyu Zhu; Boyang Zhu; Xueyuan Gu; Mei Li; Rong Ji; Qing Zhou (Bulletin of Environmental Contamination and Toxicology, 2021)

Difference in the binding mechanism of distinct antimony forms in bovine serum albumin - Jiali Gu; Gang Yang; Xiang Li; Qian He; Xiyao Huang; Ting Sun (BioMetals, 2021)

RNA-seq reveals plant virus composition and diversity in alfalfa, thrips, and aphids in Beijing, China - Jin Li; Hongchang Gu; Yanqi Liu; Shuhua Wei; Guixin Hu; Xuemin Wang; Mark Richard McNeill; Liping Ban (Archives of Virology, 2021)

The emergence of early microblade technology in the hinterland of North China: a case study based on the Xishi and Dongshi site in Henan Province - Chao Zhao; Youping Wang; Wanfa Gu; Songzhi Wang; Xiaohong Wu; Xiaoxu Gao; Youcheng Chen; Yulong Li (Archaeological and Anthropological Sciences, 2021)

A new analytical solution for deep-buried circular cavern with anchor reinforcement under seepage field - Pan Zhou; Jingpei Li; Shuancheng Gu (Arabian Journal of Geosciences, 2021)

Tritonibacter aquimaris sp. nov. and Tritonibacter litoralis sp. nov., two novel members of the Roseobacter group isolated from coastal seawater - Na Li; Xiao-yan He; Ning-hua Liu; Tie-ji Gu; Jian Li; Yu-hui Geng; Shan Zhang; Peng Wang; Hui-hui Fu; Mei Shi; Xiu-lan Chen; Yu-zhong Zhang; et al. (Antonie van Leeuwenhoek, 2021)

Construction of recombinant Escherichia coli for production of l-phenylalanine-derived compounds - Liwen Liu; Xiaozhen Liu; Qianqian Ma; Qiang Li; Pengfei Gu (World Journal of Microbiology and Biotechnology, 2021)

Inhibition of fibroblast growth factor-inducible 14 attenuates experimental tubulointerstitial fibrosis and profibrotic factor expression of proximal tubular epithelial cells - Mai Luo; Mengmeng Liu; Wei Liu; Xiao Cui; Siyue Zhai; Hanjiang Gu; Huixia Wang; Kunyi Wu; Wen Zhang; Ke Li; Yumin Xia (Inflammation Research, 2021)

Targeted deletion of HAI-1 increases prostasin proteolysis but decreases matriptase proteolysis in human keratinocytes - Dajun D. Lu; Yayun Gu; Sheng-Wen A. Li; Robert J. Barndt; Shih-Ming Huang; Jehng-Kang Wang; Hui Chen Su; Michael D. Johnson; Chen-Yong Lin (Human Cell, 2021)

Effect of juvenile omni-benthivorous fish (Carassius carassius) disturbance on the efficiency of lanthanum-modified bentonite (LMB) for eutrophication control: a mesocosm study - Yanqing Han; Qisheng Li; Hu He; Jiao Gu; Zhaoshi Wu; Xiaolong Huang; Xiaojuan Zou; You Zhang; Kuanyi Li (Environmental Science and Pollution Research, 2021)

Environmental Governance of Western Europe and Its Enlightenment to China: In Context to Rhine Basin and the Yangtze River Basin - Wangjinyu Shi; Yangyang Wu; Xue Sun; Xueyuan Gu; Rong Ji; Mei Li (Bulletin of Environmental Contamination and Toxicology, 2021)

Water Quality Analysis of the Yangtze and the Rhine River: A Comparative Study Based on Monitoring Data from 2007 to 2018 - Xuan Li; Yichen Xu; Mei Li; Rong Ji; Reto Dolf; Xueyuan Gu (Bulletin of Environmental Contamination and Toxicology, 2021)

Influence of major water conservation projects on river channels and shorelines in the middle and lower reaches of the Yangtze River - Yue-hua Jiang; He-qin Cheng; Quan-ping Zhou; Yun Li; Guo-qiang Yang; Yang Jin; Shi-jia Mei; Xuan Gu; Hong Zhang (Arabian Journal of Geosciences, 2021)

Water body extraction based on region similarity combined adaptively band selection - Lingxiao Gu; Quanhua Zhao; Guanghui Wang; Yu Li (International Journal of Remote Sensing, 2021)

Selection and optimum fertilization of Betula platyphylla hybrid clones for growth - Shuyuan Song; Siqi Cheng; Zhen Jia; Minghui Li; Jiabao Ji; Yifan Yang; Chu Wang; Chenrui Gu; Qibin Yu; Yuhui Weng; Guifeng Liu (Trees, 2021)

miR-20a Promotes the Axon Regeneration of DRG Neurons by Targeting Nr4a3 - Lili Zhao; Leilei Gong; Ping Li; Jing Qin; Lingchi Xu; Qiyao Wei; Huimin Xie; Susu Mao; Bin Yu; Xiaosong Gu; Songlin Zhou (Neuroscience Bulletin, 2021)

Effects of temperature and acid solution on the physical and tensile mechanical properties of red sandstones - Zhen Huang; Wei Zeng; Yun Wu; Shijie Li; Qixiong Gu; Kui Zhao (Environmental Science and Pollution Research, 2021)

The Fe3O4-modified biochar reduces arsenic availability in soil and arsenic accumulation in indica rice (Oryza sativa L.) - Yao Yao; Hang Zhou; Xiu-Lan Yan; Xiao Yang; Kang-Wen Huang; Juan Liu; Li-Juan Li; Jing-Yi Zhang; Jiao-Feng Gu; Yaoyu Zhou; Bo-Han Liao (Environmental Science and Pollution Research, 2021)

Impact of solar ultraviolet radiation on daily outpatient visits of atopic dermatitis in Shanghai, China - Hui-jing Gu; Li Peng; Wen-cai Jiang; Yi-mei Tan; Guo-jiang Zhou; Hai-dong Kan; Ren-jie Chen; Ying Zou (Environmental Science and Pollution Research, 2021)

Increased depression risk for elderly women with high blood levels of strontium and barium - Jia Lv; Yan-ling Li; Wen-qiang Ren; Rong Li; Jian-rong Chen; Chao Bao; Zhi-ping Du; Shun Feng; Ling Gu; Hui Gao; Kai-yong Liu; Lin-sheng Yang; et al. (Environmental Chemistry Letters, 2021)

Chelativorans alearense sp. nov., A Novel Bacterial Species Isolated From Soil in Alear, China - Dong Meng; Yu-Ling Liu; Peng-Fei Gu; Xiang-Yu Fan; Zhao-Song Huang; Yan Ji; Wei-Min Li; Zong-Jun Du; Qiang Li (Current Microbiology, 2021)

Association Between Blood Heavy Metal Concentrations and Dyslipidemia in the Elderly - Xingmeng Zhu; Yong Fan; Jie Sheng; Ling Gu; Qi Tao; Rui Huang; Kaiyong Liu; Linsheng Yang; Guimei Chen; Hongjuan Cao; Kaichun Li; Fangbiao Tao; et al. (Biological Trace Element Research, 2021)

Numerical simulation of roof movement and fill strength of coal deep mining - Tao Li; Baogui Yang; Zheng Qi; Chengjin Gu; Qiyuan Shan; Weixin Chen (Arabian Journal of Geosciences, 2021)

The effects of land use changes on climate warming by source-sink theory - Shuang-shuang Hou; Li-fei Yu; Wei Yan; Shu-hong Gu; Xiao-ping Gu (Arabian Journal of Geosciences, 2021)

The differential evolution of nanopores in discrete OM and organic-clay composites for shale: insights from stress manipulation - Yuantao Gu; Xiaoxia Li; Quan Wan; Shuguang Yang (Arabian Journal of Geosciences, 2021)

Honokiol induces paraptosis-like cell death of acute promyelocytic leukemia via mTOR & MAPK signaling pathways activation - Xiaoli Liu; Yan Gu; Yaoyao Bian; Danhong Cai; Yu Li; Ye Zhao; Zhaofeng Zhang; Mei Xue; Liang Zhang (Apoptosis, 2021)
Acute promyelocytic leukemia (APL) is a blood system disease caused by the accumulation of a large number of immature blood cells in bone marrow. Although the introduction of all- trans retinoic acid (ATRA) and arsenic has reached a high level of complete remission rate and 5-year disease-free survival rate, the occurrence of various adverse reactions still severely affects the quality of life of patients. As a natural product, honokiol (HNK) has the advantages of low toxicity and high efficiency, and it is a potential drug for the treatment of cancer. Since cancer cells can escape apoptotic cell death through multiple adaptive mechanisms, HNK, a drug that induces cancer cell death in a nonapoptotic way, has attracted much interest. We found that HNK reduced the viability of human APL cell line (NB4 cells) by inducing paraptosis-like cell death. The process was accompanied by excessive reactive oxygen species (ROS), mitochondrial damage, endoplasmic reticulum stress, and increased microtubule-associated protein 1 light chain 3 (LC3) processing. The inactivation of proteasome activity was the main cause of misfolded and unfolded protein accumulation in endoplasmic reticulum, such as LC3II/I and p62. This phenomenon could be alleviated by adding cycloheximide (CHX), a protein synthesis inhibitor. We found that mTOR signaling pathway participated in paraptosis-like cell death induced by HNK in an autophagy-independent process. Moreover, the mitogen-activated protein kinase (MAPK) signaling pathway induced paraptosis of NB4 cells by promoting endoplasmic reticulum stress. In summary, these findings indicate that paraptosis may be a new way to treat APL, and provide novel insights into the potential mechanism of paraptosis-like cell death.

High-Throughput, Fluorescence-Based Esterase Activity Assay for Assessing Polysorbate Degradation Risk during Biopharmaceutical Development - Adithi C. Bhargava; Kathryn Mains; Albert Siu; Jie Gu; Jonathan Zarzar; Li Yi; Inn H. Yuk (Pharmaceutical Research, 2021)

Docosahexaenoic Acid (DHA) Supplementation Alters Phospholipid Species and Lipid Peroxidation Products in Adult Mouse Brain, Heart, and Plasma - Grace Y. Sun; Michael K. Appenteng; Runting Li; Taeseon Woo; Bo Yang; Chao Qin; Meixia Pan; Magdalena Cieślik; Jiankun Cui; Kevin L. Fritsche; Zezong Gu; Matthew Will; et al. (NeuroMolecular Medicine, 2021)

EphA1 Activation Induces Neuropathological Changes in a Mouse Model of Parkinson’s Disease Through the CXCL12/CXCR4 Signaling Pathway - Jianjun Ma; Zhidong Wang; Siyuan Chen; Wenhua Sun; Qi Gu; Dongsheng Li; Jinhua Zheng; Hongqi Yang; Xue Li (Molecular Neurobiology, 2021)

Stoichiometric analysis of an arable crop–soil–microbe system after repeated fertilizer and compost application for 10 years - Yi Yang; Rongbo Ji; Hongyan Zhang; Peter Christie; Gu Feng; Xiaolin Li; Jingping Gai (Journal of Soils and Sediments, 2021)

The metabolic and immunological characteristics of pregnant women with COVID-19 and their neonates - Jingjiao Zhou; Yudie Wang; Juan Zhao; Lixing Gu; Cheng Yang; Jun Wang; Heng Zhang; Yu Tian; Hu Tuo; Dan Li; Min Wei; Bing He (European Journal of Clinical Microbiology & Infectious Diseases, 2021)

Alcanivorax profundimaris sp. nov., a Novel Marine Hydrocarbonoclastic Bacterium Isolated from Seawater and Deep-Sea Sediment - Chunming Dong; Qiliang Lai; Xiupian Liu; Li Gu; Yu Zhang; Zhangxian Xie; Dazhi Wang; Zongze Shao (Current Microbiology, 2021)

Chelativorans xinjiangense sp. nov., a novel bacterial species isolated from soil in Xinjiang, China - Dong Meng; Yu-Ling Liu; Peng-Fei Gu; Xiang-Yu Fan; Zhao-Song Huang; Yan Ji; Wei-Min Li; Zong-Jun Du; Qiang Li (Archives of Microbiology, 2021)

Propylenella binzhouense gen. nov., sp. nov. isolated from activated sludge, and proposal of Propylenellaceae fam. nov. - Yu-Ling Liu; Dong Meng; Fang Wang; Xiao-Fan Gong; Peng-Fei Gu; Xiang-Yu Fan; Zong-Jun Du; Ji-Dong Zou; Qiang Li (Antonie van Leeuwenhoek, 2021)

Moisture availability mediates the relationship between terrestrial gross primary production and solar‐induced chlorophyll fluorescence: Insights from global‐scale variations - Anping Chen; Jiafu Mao; Daniel Ricciuto; Jingfeng Xiao; Christian Frankenberg; Xing Li; Peter E. Thornton; Lianhong Gu; Alan K. Knapp (Global Change Biology, 2021)
Effective use of solar‐induced chlorophyll fluorescence (SIF) to estimate and monitor gross primary production (GPP) in terrestrial ecosystems requires a comprehensive understanding and quantification of the relationship between SIF and GPP. To date, this understanding is incomplete and somewhat controversial in the literature. Here we derived the GPP/SIF ratio from multiple data sources as a diagnostic metric to explore its global‐scale patterns of spatial variation and potential climatic dependence. We found that the growing season GPP/SIF ratio varied substantially across global land surfaces, with the highest ratios consistently found in boreal regions. Spatial variation in GPP/SIF was strongly modulated by climate variables. The most striking pattern was a consistent decrease in GPP/SIF from cold‐and‐wet climates to hot‐and‐dry climates. We propose that the reduction in GPP/SIF with decreasing moisture availability may be related to stomatal responses to aridity. Furthermore, we show that GPP/SIF can be empirically modeled from climate variables using a machine learning (random forest) framework, which can improve the modeling of ecosystem production and quantify its uncertainty in global terrestrial biosphere models. Our results point to the need for targeted field and experimental studies to better understand the patterns observed and to improve the modeling of the relationship between SIF and GPP over broad scales.

Morphology and Phylogeny of Scrippsiella precaria Montresor & Zingone (Thoracosphaerales, Dinophyceae) from Korean Coastal Waters - Hyun Jung Kim; Zhun Li; Nam Seon Kang; Haifeng Gu; Daekyung Kim; Min Ho Seo; Sang Deuk Lee; Suk Min Yun; Seok-Jin Oh; Hyeon Ho Shin (Journal of Marine Science and Engineering, 2021)
The dinoflagellate genus Scrippsiella is a common member of phytoplankton and their cysts are also frequently reported in coastal sediments worldwide. However, the diversity of Scrippsiella in Korean waters has not been fully investigated. Here, several isolates of Scrippsiella precaria collected from Korean waters and germinated from resting cysts were examined using light and scanning electron microscopy. The resting cysts were characterized by pointed calcareous spines and one or two red accumulation bodies, and the archeopyle was mesoepicystal, representing the loss of 2–4′ and 1–3a paraplates. Rounded resting cysts were found in culture, and an increase in spine length was observed until 8 days of development. Korean isolates of S. precaria had the plate formula of Po, X, 4′, 3a, 7″, 6C, 4S, 5‴, 2⁗. There were differences in the cell size and location of the red body between Korean isolates and previously described cells of S. precaria. In addition, the Korean isolates of S. precaria had two types of the 5″ plate that either contacted the 2a plate or not. Molecular phylogeny based on internal transcribed spacer (ITS) and large subunit (LSU) rDNA sequences revealed that the Korean isolates were nested within the subclade of PRE (S. precaria and related species) in the clade of Scrippsiella sensu lato, and that the PRE subclade had two ribotypes: ribotype 1 consisting of the isolates from Korea, China, and Australia, and ribotype 2 consisting of the isolates from Italy and Greece. Lineages between isolates of ribotype 1 were likely to be related to the dispersal by ocean currents and ballast waters from international shipping, and the two types of spine shapes and locations of the 5″ plates may be a distinct feature for ribotype 1.

An Innovative Emergy Quantification Method for Eco-economic Compensation for Agricultural Water Rights Trading - Cuimei Lv; Huiqin Li; Minhua Ling; Xi Guo; Zening Wu; Changkuan Gu; Yang Li (Water Resources Management, 2021)

Application of the borderline-SMOTE method in susceptibility assessments of debris flows in Pinggu District, Beijing, China - Yongchao Li; Jianping Chen; Chun Tan; Yang Li; Feifan Gu; Yiwei Zhang; Qaiser Mehmood (Natural Hazards, 2021)

Molecular Regulatory Mechanism and Toxicology of Neurodegenerative Processes in MPTP/Probenecid-Induced Progressive Parkinson’s Disease Mice Model Revealed by Transcriptome - Weiwei Yang; Wenwen Hao; Zhuo Meng; Shiyan Ding; Xiaodi Li; Tao Zhang; Weixiao Huang; Lian Xu; Yu Zhang; Jian Yang; Xiaosong Gu (Molecular Neurobiology, 2021)
Parkinson’s disease (PD) is a neurodegenerative disease caused by a variety of unclear complex pathogenic factors. The 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine/probenecid (MPTP/p)-induced progressive PD mice is a well-recognized classic model for studying PD, but the molecular toxicology of this model is still unclear. Here, for the first time, we report gradual neurodegenerative processes in MPTP/p-induced progressive PD mice model using RNA-seq. Transcriptional responses are orchestrated to regulate the expression of many genes in substantia nigra, such as Ntf3 , Pitx3 , Th , and Drd2 , leading to the degeneration of dopaminergic neurons at last. We proposed that the established model could be divided into three phases based on their molecular toxicological features: “the stress response phase” which maintained the microenvironment homeostasis, “the pre-neurodegenerative phase” which demonstrated observed MPTP/p cytotoxicity and gradual degeneration of dopaminergic neurons, and “the neurodegenerative phase” which reflected distinct damage and dopaminergic neuron apoptotic process. Glia cells exhibited a certain protective effect on dopaminergic neurons in 3rd and 6th MPTP/p-induced cytotoxicity. But in 10th MPTP/p injection, glia cells play a promoting role in PD and tissue damages caused by oxidative stress. This study also indicated that the substantia nigra of PD mice showed unique patterns of changes at each stage. Moreover, neurotrophic signaling pathway, ECM-receptor interaction, oxidative phosphorylation, apoptosis and necroptosis were enriched at 3rd and 6th MPTP/p injection, which might be associated with the PD progress. This study provided an extensive data set of molecular toxicology for elucidating of PD progression and offered comprehensive theoretical knowledge for the development of new therapy.

Melatonin upregulates DNA-PKcs to suppress apoptosis of human umbilical vein endothelial cells via inhibiting miR-101 under H2O2-induced oxidative stress - Hao Gu; Jian Li; Rongrong Zhang (Molecular and Cellular Biochemistry, 2021)

Studies of anticancer activity in vivo and in vitro behaviors of liposomes encapsulated iridium(III) complex - Yiying Gu; Haoyu Wen; Yuanyuan Zhang; Lan Bai; Yi Zhou; Huiwen Zhang; Li Tian; Jing Hao; Yunjun Liu (JBIC Journal of Biological Inorganic Chemistry, 2021)

Investigation on the treatment effect of slope wetland on pollutants under different hydraulic retention times - Jia Wang; Yonggang Gu; Hao Wang; Zhaoxin Li (Environmental Science and Pollution Research, 2021)

Sustained effects of one-time sewage sludge addition on rice yield and heavy metals accumulation in salt-affected mudflat soil - Wengang Zuo; Yanchao Bai; Ming Lv; Zehui Tang; Cheng Ding; Chuanhui Gu; Yuhua Shan; Qigen Dai; Min Li (Environmental Science and Pollution Research, 2021)

Effects of perceived value on green consumption intention based on double-entry mental accounting: taking energy-efficient appliance purchase as an example - Ting Yue; Junli Liu; Ruyin Long; Hong Chen; Qianwen Li; Haiwen Liu; Yu Gu (Environmental Science and Pollution Research, 2021)

Coherence resonance for neuronal bursting with spike undershoot - Ben Cao; Runxia Wang; Huaguang Gu; Yuye Li (Cognitive Neurodynamics, 2021)

Neural interactions in occipitotemporal cortex during basic human movement perception by dynamic causal modeling - Jin Gu; Baolin Liu; Xiaolin Sun; Fangyuan Ma; Xianglin Li (Brain Imaging and Behavior, 2021)

The Association Between Trace Elements Exposure and the Cognition in the Elderly in China - Ling Gu; Jinhui Yu; Yong Fan; Sufang Wang; Linsheng Yang; Kaiyong Liu; Qunan Wang; Guimei Chen; Dongmei Zhang; Ying Ma; Li Wang; Annuo Liu; et al. (Biological Trace Element Research, 2021)

The N-terminal cysteine protease domain of rice stripe tenuivirus Pc1 possesses deubiquitinating enzyme activity - Shuling Zhao; Xiaomei Gu; Jie Li; Changyong Liang (Virus Genes, 2021)

Identification and Characterization of a Novel Alkali- and High Temperature-Tolerant Lipase (Lip4346) from a Macroalgae-Associated Bacterial Strain - Xiaoqian Gu; Yuanyuan Gui; Jiang Li; Xuelei Zhang; Dewi Seswita Zilda (Journal of Ocean University of China, 2021)

Dynamics of the seasonal wave height variability in the South China Sea - Fangguo Zhai; Wenfan Wu; Yanzhen Gu; Peiliang Li; Zizhou Liu (International Journal of Climatology, 2021)
Wind‐driven ocean surface gravity waves exhibit large fluctuations on multiple scales in both space and time, which greatly impact on air‐sea interactions and human activities in the ocean. The wave height in the South China Sea (SCS) is dominated by the seasonal variability, but the underlying dynamics is poorly understood. Therefore, this study aims to investigate the dynamics of the significant wave height (SWH) seasonality in the SCS using the WAVEWATCH III wave model. The results indicate that the SCS SWH seasonality is dominated by local sea surface winds inside the SCS with a secondary contribution from remote sea surface winds in the tropical western North Pacific Ocean through the propagation of waves. Local sea surface winds alone lead to the SWH maxima occurring in different regions inside the SCS in different seasons. Remote sea surface winds, on the contrary, result in a high SWH tongue extending from the Pacific Ocean into the SCS through the Luzon Strait all year round. They contribute positively to the SCS SWH seasonality, but the contributions are only significant in the northern SCS and decrease westward/southwestward from the Luzon Strait. The SWH in the northern SCS induced by the seasonality of remote sea surface winds is largest in winter while smallest in summer. However, the contribution of remote sea surface winds relative to that of local sea surface winds gets largest in spring, when the local sea surface winds are weakest of the year. The current study emphasizes the importance of sea surface winds in the Pacific Ocean in regulating the SCS SWH seasonality and is helpful for further studies of the dynamics and predictions of wave climate variabilities on multiple time scales in the SCS.

How well do the ERA‐Interim , ERA ‐5, GLDAS ‐2.1 and NCEP‐R2 reanalysis datasets represent daily air temperature over the Tibetan Plateau? - Li Liu; Haiting Gu; Jingkai Xie; Yue‐Ping Xu (International Journal of Climatology, 2021)
Snow and glacier are important components in the hydrological cycle of the Tibetan Plateau (TP). Air temperature, as the main driver in freezing and thawing processes, becomes vital for hydrological modelling and prediction in this region. Due to a sparse ground gauging network, spatial density of air temperature measurement is insufficient for hydro‐meteorological studies. Therefore, the aim of this study is to identify the best representative temperature data for hydrological applications from four widely used reanalysis products, including ERA‐Interim, ERA‐5, GLDAS‐2.1 and NCEP‐R2, with reference to in situ measurements and gridded snow depth from the year 2008–2017 over the entire TP. To reduce errors, Bayesian Joint Probability (BJP) approach based on K‐Nearest Neighbour (KNN) classification algorithm (KNN‐BJP) is proposed to post‐process gridded reanalyses. The results indicate that all the reanalysis datasets provide highly correlated but cold biased air temperature. The correlation ecoefficiency is greater than 0.85. The cold biases are near −3 ° C and mainly distributed in the southeastern TP. Bias in daily maximum temperature during Spring is greater than −8 ° C for most stations. ERA‐Interim is found to have the closest agreement with in situ measurements, closely followed by GLDAS‐2.1. KNN‐BJP is found to be effective within a distance smaller than 5° . After post‐processing, the prominent underestimation is efficiently corrected with Bias near 0. RMSE is markedly reduced to be smaller than 2.5 ° C . The post‐processed ERA‐5 and GLDAS‐2.1 are as accurate as ERA‐Interim, but able to provide more detailed information for extreme events due to their finer spatial resolution. Thus, ERA‐5 and GLDAS‐2.1 are more recommended to represent air temperature in the TP. Snow depth as complementary reference data is able to present spatial variance of air temperature. Our study can help alleviate the problem of sparse air temperature data over the TP.

New nitrogen-containing metabolites from cultures of rice false smut pathogen Villosiclava virens - Ali Wang; Peng Li; Peipei Han; Gan Gu; Tijiang Shan; Daowan Lai; Ligang Zhou (Natural Product Research, 2021)

Multi-objective Emergency Scheduling for Geological Disasters - Wan Fang; Guo Haixiang; Li Jinling; Gu Mingyun; Pan Wenwen (Natural Hazards, 2021)

Hypoxia-reoxygenation induces macrophage polarization and causes the release of exosomal miR-29a to mediate cardiomyocyte pyroptosis - Yan Wang; Zhimei Qiu; Jinson Yuan; Chaofu Li; Ranzun Zhao; Weiwei Liu; Wenwen Deng; Ning Gu; Wei Zhang; Shan Hu; Zhixun Bai; Bei Shi (In Vitro Cellular & Developmental Biology - Animal, 2021)

The bioaerosols emitted from toilet and wastewater treatment plant: a literature review - Mengmeng Lou; Shuai Liu; Chunjie Gu; Huimin Hu; Zhengkun Tang; Yaopeng Zhang; Chenye Xu; Fang Li (Environmental Science and Pollution Research, 2021)

Adsorption mechanism of rhein-coated Fe3O4 as magnetic adsorbent based on low-field NMR - Xu Sun; Li Xu; Weina Jiang; Yan Xuan; Wen Lu; Zhong Li; Shilong Yang; Zhenzhen Gu (Environmental Science and Pollution Research, 2021)

Genetic variants in Hippo signalling pathway-related genes affect the risk of colorectal cancer - Hengyang Shen; Yixuan Meng; Tao Hu; Shuwei Li; Mulong Du; Junyi Xin; Dongying Gu; Meilin Wang; Zan Fu (Archives of Toxicology, 2021)

Hydrothermal dolomitization in the Middle Permian in the Central Sichuan Basin, SW China: evidence from petrology, geochemistry, and fluid inclusions - Lin Qi; Yifan Gu; Puwei He; Zhanlei Wang; Yuqiang Jiang; Shun Li; Yadong Zhou (Arabian Journal of Geosciences, 2021)

Production of functional human nerve growth factor from the submandibular glands of mice using a CRISPR/Cas9 genome editing system - Yi Gu; Hui Cao; Fei Li; Jianli Yu; Rui Nian; Dongxiao Feng; Jingtao Lin; Haipeng Song; Wenshuai Liu (World Journal of Microbiology and Biotechnology, 2020)

A high-density genetic map and multiple environmental tests reveal novel quantitative trait loci and candidate genes for fibre quality and yield in cotton - Qishen Gu; Huifeng Ke; Zhengwen Liu; Xing Lv; Zhengwen Sun; Man Zhang; Liting Chen; Jun Yang; Yan Zhang; Liqiang Wu; Zhikun Li; Jinhua Wu; et al. (Theoretical and Applied Genetics, 2020)

Factors associated with a SARS-CoV-2 recurrence after hospital discharge among patients with COVID-19: systematic review and meta-analysis - Meng-qi Yao; Qiu-xian Zheng; Jia Xu; Jing-wen Deng; Tian-tian Ge; Hai-bo Zhou; Feng-tian Wu; Xin-yu Gu; Qin Yang; Yan-li Ren; Gang Wang; Zhi Chen (Journal of Zhejiang University-SCIENCE B, 2020)

Update on recommendations for the diagnosis and treatment of SARS-CoV-2 infection in children - Hongjun Miao; Han Li; Yinying Yao; Mingfu Wu; Chao Lu; Jun Wang; Man Tian; Ying Li; Peiliang Luo; Jianhui Gu; Bin Yuan; Shouchuan Wang; et al. (European Journal of Clinical Microbiology & Infectious Diseases, 2020)
Since the outbreak of novel coronavirus infection pneumonia in Wuhan City, China, in late 2019, such cases have been gradually reported in other parts of China and abroad. Children have become susceptible to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) because of their immature immune function. As the outbreak has progressed, more cases of novel coronavirus infection/pneumonia in children have been reported. Compared with adults, the impact of SARS-CoV-2 infection in children is less severe, with a lower incidence and susceptibility in children, which results in fewer children being tested, thereby underestimating the actual number of infections. Therefore, strengthening the diagnosis of the disease is particularly important for children, and early and clear diagnosis can determine treatment strategies and reduce the harm caused by the disease to children. According to the Novel Coronavirus Infection Pneumonia Diagnosis and Treatment Standards ( trial version 7 ) issued by National Health Committee and the latest diagnosis and treatment strategies for novel coronavirus infection pneumonia in children, this review summarizes current strategies on diagnosis and treatment of SARS-CoV-2 infection in children.

An approach for water-inrush risk assessment of deep coal seam mining: a case study in Xinlongzhuang coal mine - Qixiong Gu; Zhen Huang; Shijie Li; Wei Zeng; Yun Wu; Kui Zhao (Environmental Science and Pollution Research, 2020)

Blood biochemistry profile of Qihe crucian carp Carassius auratus in different aquaponic systems - Yang Gao; Guorong Zhu; Yuan Tian; Kang Li; Yanjing Zhao; Junping Liang; Qianhong Gu; Xuejun Li (Environmental Science and Pollution Research, 2020)

Effects of juvenile crucian carp (Carassius carassius) removal on submerged macrophyte growth—implications for subtropical shallow lake restoration - Yanqing Han; Jiao Gu; Qisheng Li; You Zhang; Hu He; Ruijie Shen; Kuanyi Li (Environmental Science and Pollution Research, 2020)

Hydrogeochemical Characteristics and Impact of Arsenic Released from a Gold Deposit in Tibet - Hongyu Gu; Huayong Ni; Yingchun Wang; Yujie Liu; Dan Li; Zhi Zhang (Mine Water and the Environment, 2020)

Molecular cloning, expression and mimicking antiviral activity analysis of retinoic acid-inducible gene-I in duck (Anas platyrhynchos) - Tiantian Gu; Guoqin Li; Yong Tian; Li Chen; Xinsheng Wu; Tao Zeng; Qi Xu; Spyrydonov Vladyslav; Guohong Chen; Lizhi Lu (Journal of Genetics, 2020)

Enhancement of chlortetracycline biodegradation with Trichoderma harzianum LJ245 and its spore-producing mutants using co-metabolism - Yanju Li; Yu Gong; Huiying Zhao; Jingang Gu; Zinuo Wang; Xuli He (Biodegradation, 2020)

Estimation of surface energy fluxes in the permafrost region of the Tibetan Plateau based on in situ measurements and the surface energy balance system model - Jimin Yao; Lianglei Gu; Cheng Yang; Hao Chen; Jiemin Wang; Yongjian Ding; Ren Li; Lin Zhao; Yao Xiao; Yongping Qiao; Jianzong Shi; Caiping Chen (International Journal of Climatology, 2020)
The surface energy balance is a key issue in land surface process research and important for studies of climate and hydrology. In this paper, the surface energy fluxes (net radiation, ground heat flux, sensible heat flux and latent heat flux) at the Tanggula (TGL) and Xidatan (XDT) sites were measured and the distributions of the regional surface energy fluxes on the Tibetan Plateau were obtained using a revised surface energy balance system (SEBS) model. The results show that the surface energy fluxes have obvious seasonal variations. At both sites, the sensible heat flux is highest in spring and lowest in summer, and the latent heat flux is highest in summer and lowest in winter. The high elevation, snow cover, freeze–thaw process, precipitation, vegetation and soil texture are important influencing factors for land surface energy fluxes. The time‐phase difference between the net radiation and ground heat flux for bare soils is estimated to be 2–3 hr. The ratio of ground heat flux and net radiation ranged from approximately 0.18 to 0.33, and a parameterization scheme for the remote sensing of ground heat flux over the Tibetan Plateau bare soil in summer is developed. The simulation results of the regional surface energy fluxes show that the distributions of surface parameters, such as vegetation, soil texture and soil moisture content, are important for understanding regional changes in the surface energy fluxes.

Activation of p62-Keap1-Nrf2 Pathway Protects 6-Hydroxydopamine-Induced Ferroptosis in Dopaminergic Cells - Yiran Sun; Libo He; Taoyu Wang; Wan Hua; Huan Qin; Jingjin Wang; Li Wang; Wanqin Gu; Tingting Li; Na Li; Xinanbei Liu; Fang Chen; et al. (Molecular Neurobiology, 2020)

Design and synthesis of novel spirooxindole–indenoquinoxaline derivatives as novel tryptophanyl-tRNA synthetase inhibitors - Wen Ren; Qian Zhao; Meng Yu; Li Guo; Hongmei Chang; Xian Jiang; Youfu Luo; Wei Huang; Gu He (Molecular Diversity, 2020)

SRGN, a new identified shear-stress-responsive gene in endothelial cells - Qinfeng Ma; Wei Gu; Tianhan Li; Kun Zhang; Yuliang Cui; Kai Qu; Nan Wang; Rose Humphry; Colm Durkan; Juhui Qiu; Guixue Wang (Molecular and Cellular Biochemistry, 2020)

The Niushou landslide in Nanjing City, Jiangsu Province of China: a slow-moving landslide triggered by rainfall - Zinan Li; Faming Zhang; Wen Gu; Menglong Dong (Landslides, 2020)

Visual form perception predicts 3-year longitudinal development of mathematical achievement - Xinlin Zhou; Yuwei Hu; Li Yuan; Tianan Gu; Dawei Li (Cognitive Processing, 2020)

Food-grade expression of nattokinase in Lactobacillus delbrueckii subsp. bulgaricus and its thrombolytic activity in vitro - Chen Li; Zaihui Du; Shaoqing Qi; Xin Zhang; Miaoshu Wang; Yangping Zhou; Haiqiang Lu; Xinxi Gu; Hongtao Tian (Biotechnology Letters, 2020)

Control of the rubber anthracnose fungus Colletotrichum gloeosporioides using culture filtrate extract from Streptomyces deccanensis QY-3 - Liushuang Gu; Kai Zhang; Nan Zhang; Xiaoyu Li; Zhiqiang Liu (Antonie van Leeuwenhoek, 2020)

Polymerization and Carbonization Behaviors of 2-Methylnaphthalene in Contaminated Soil During Thermal Desorption - Liao He; Yimin Sang; Wang Yu; Wanxin Li; Yuhai Jiao; Fujun Ma; FasHeng Li; Yuqin Liu; Qingbao Gu (Water, Air, & Soil Pollution, 2020)

Trophic Ecology and Ecological Function for Oriental River Prawn (Macrobrachium nipponense) in the South-to-North Canal System - Man Zhang; Nan Li; Binhe Gu; Yuncong Li; Yifan Wang; Wenguang Dong; Yunni Gao; Chuanjiang Zhou; Guoxing Nie (Wetlands, 2020)

Impacts of atmospheric and oceanic initial conditions on boreal summer intraseasonal oscillation forecast in the BCC model - Zhongkai Bo; Xiangwen Liu; Weizong Gu; Anning Huang; Yongjie Fang; Tongwen Wu; Weihua Jie; Qiaoping Li (Theoretical and Applied Climatology, 2020)
In this paper, we evaluate the capability of the Beijing Climate Center Climate System Model (BCC-CSM) in simulating and forecasting the boreal summer intraseasonal oscillation (BSISO), using its simulation and sub-seasonal to seasonal (S2S) hindcast results. Results show that the model can generally simulate the spatial structure of the BSISO, but give relatively weaker strength, shorter period, and faster transition of BSISO phases when compared with the observations. This partially limits the model’s capability in forecasting the BSISO, with a useful skill of only 9 days. Two sets of hindcast experiments with improved atmospheric and atmosphere/ocean initial conditions (referred to as EXP1 and EXP2, respectively) are conducted to improve the BSISO forecast. The BSISO forecast skill is increased by 2 days with the optimization of atmospheric initial conditions only (EXP1), and is further increased by 1 day with the optimization of both atmospheric and oceanic initial conditions (EXP2). These changes lead to a final skill of 12 days, which is comparable to the skills of most models participated in the S2S Prediction Project. In EXP1 and EXP2, the BSISO forecast skills are improved for most initial phases, especially phases 1 and 2, denoting a better description for BSISO propagation from the tropical Indian Ocean to the western North Pacific. However, the skill is considerably low and insensitive to initial conditions for initial phase 6 and target phase 3, corresponding to the BSISO convection’s active-to-break transition over the western North Pacific and BSISO convection’s break-to-active transition over the tropical Indian Ocean and Maritime Continent. This prediction barrier also exists in many forecast models of the S2S Prediction Project. Our hindcast experiments with different initial conditions indicate that the remarkable model errors over the Maritime Continent and subtropical western North Pacific may largely account for the prediction barrier.

Isolation and characterization of 20 polymorphic microsatellites loci for Xenocypris davidi based on high-throughput sequencing - Aihuan Guo; Julin Yuan; Qingping Lian; Ming Li; Zhimin Gu (Molecular Biology Reports, 2020)

Potassic-hastingsite, KCa2(Fe2+4Fe3+)(Si6Al2)O22(OH)2, from the Keshiketeng Banner, Inner Mongolia, China: description of the neotype and its implication - Guangming Ren; Guowu Li; Jiaxin Shi; Xiangping Gu; Guang Fan; Apeng Yu; Qiuxiao Liu; Ganfu Shen (Mineralogy and Petrology, 2020)

Do changes in water depth and water level influence the diatom diversity of Yunlong Lake, in Yunnan Province, Southwest China? - Yafei Zou; Luo Wang; Huiming Xu; Yao Yan; Jiaoyang Zhang; Yuan Liu; Peng Li; Zhiyuan Peng; Zhaoyan Gu; Houyuan Lu (Journal of Paleolimnology, 2020)

Pretreatment with interleukin 35-engineered mesenchymal stem cells protected against lipopolysaccharide-induced acute lung injury via pulmonary inflammation suppression - Xiaoning Zhang; Zhiqiang Zhang; Mingyan Ju; Jiaci Li; Yaqing Jing; Yuxia Zhao; Chao Gu; Ming Dong; Guang Li; Yi Liu (Inflammopharmacology, 2020)

GalNAc-T3 and MUC1, a combined predictor of prognosis and recurrence in solitary pulmonary adenocarcinoma initially diagnosed as malignant solitary pulmonary nodule (≤ 3 cm) - Qiang Xie; Fengzhou Li; Shilei Zhao; Tao Guo; Zhuoshi Li; Lei Fang; Shiqing Wang; Wenzhi Liu; Chundong Gu (Human Cell, 2020)

Analysis of the Endophytic Bacteria Community Structure and Function of Panax notoginseng Based on High-Throughput Sequencing - Chen Zhang; Xuan Ma; Runqi Zhu; Zhenzhen Liu; Mengmeng Gu; Jingyuan Zhang; Yu Li; Yanyan Xu; Daheng Zhu (Current Microbiology, 2020)