Transcriptome Profiling Revealed Basis for Growth Heterosis in Hybrid Tilapia (Oreochromis niloticus ♀ × O. aureus ♂) - Jinglin Zhu; Zhiying Zou; Dayu Li; Wei Xiao; Jie Yu; Binglin Chen; Liangyi Xue; Hong Yang (Fishes, 2022)
Hybrid tilapia were produced from hybridization of Nile tilapia (Oreochromis niloticus) and blue tilapia (O. aureus). Comparative transcriptome analysis was carried out on the liver of hybrid tilapia and their parents by RNA sequencing. A total of 2319 differentially expressed genes (DEGs) were identified. Trend co-expression analysis showed that non-additive gene expression accounted for 67.1% of all DEGs. Gene Ontology and KEGG enrichment analyses classified the respective DEGs. Gene functional enrichment analysis indicated that most up-regulated genes, such as FASN, ACSL1, ACSL3, ACSL6, ACACA, ELOVL6, G6PD, ENO1, GATM, and ME3, were involved in metabolism, including fatty acid biosynthesis, unsaturated fatty acid biosynthesis, glycolysis, pentose phosphate pathway, amino acid metabolism, pyruvate metabolism, and the tricarboxylic acid cycle. The expression levels of a gene related to ribosomal biosynthesis in eukaryotes, GSH-Px, and those associated with heat shock proteins (HSPs), such as HSPA5 and HSP70, were significantly down-regulated compared with the parent tilapia lineages. The results revealed that the metabolic pathway in hybrid tilapia was up-regulated, with significantly improved fatty acid metabolism and carbon metabolism, whereas ribosome biosynthesis in eukaryotes and basal defense response were significantly down-regulated. These findings provide new insights into our understanding of growth heterosis in hybrid tilapia.

Fine mapping of the tiller inhibition gene TIN4 contributing to ideal plant architecture in common wheat - Zhiqiang Wang; Fangkun Wu; Xudong Chen; Wanlin Zhou; Haoran Shi; Yu Lin; Shuai Hou; Shifan Yu; Hong Zhou; Caixia Li; Yaxi Liu (Theoretical and Applied Genetics, 2022)

LINC01087 indicates a poor prognosis of glioma patients with preoperative MRI - Wangsheng Chen; Fei Wang; Jianhua Zhang; Changqing Li; Lan Hong (Functional & Integrative Genomics, 2022)
Long intergenic non-coding RNA 01,087 (LINC01087) has been concerned as an oncogene in breast cancer, while its mechanism in glioma has been little surveyed. Thus, we searched the prognostic value and functional action of LINC01087 in glioma. Glioma patients after preoperative MRI diagnosis were enrolled, and LINC01087, microRNA (miR)-1277-5p, and alkaline ceramidase 3 (ACER3) levels were tested in glioma cancer tissue. The correlation between LINC01087 expression and the survival of patients were analyzed. LINC01087, miR-1277-5p, and ACER3 levels in U251 cells were altered via transfection, and cell malignant phenotypes were monitored. The relationship between miR-1277-5p and LINC01087 or ACER3 was detected. The LINC01087 and ACER3 expression was in up-regulation and the miR-1277-5p expression was in down-regulation in clinical glioma samples. High expression of LINC01087 was associated with poor prognosis of glioma patients with preoperative MRI. LINC01087 silencing restrained tumor malignancy in glioma cells. Mechanistically, LINC01087 directly interacted with miR-1277-5p. ACER3 was a known target of miR-1277-5p. Moreover, rescue assays reveal that miR-1277-5p overexpression (or ACER3 overexpression) reversed the effects of LINC01087 upregulation (or miR-1277-5p upregulation) on glioma cells. LINC01087 has prognostic significance in glioma and silencing LINC01087 deters glioma development through elevating miR-1277-5p to reduce ACER3 expression.

Lederbergia citri sp. nov., and Lederbergia citrisecundus sp. nov., isolated from citrus rhizosphere - Guo-Hong Liu; Manik Prabhu Narsing Rao; Qian-Qian Chen; Jian-Mei Che; Huai Shi; Bo Liu; Wen-Jun Li (Current Microbiology, 2022)

Aberrant functional and effective connectivity of the frontostriatal network in unilateral acute tinnitus patients with hearing loss - Gang-Ping Zhou; Yu-Chen Chen; Wang-Wei Li; Heng-Le Wei; Yu-Sheng Yu; Qing-Qing Zhou; Xindao Yin; Yue-Jin Tao; Hong Zhang (Brain Imaging and Behavior, 2022)

Responses and feedback of litter properties and soil mesofauna to herbaceous plants expansion into the alpine tundra on Changbai Mountain, China - Ying-jie Zhang; Ying-hua Jin; Jia-wei Xu; Hong-shi He; Yan Tao; Zhi-peng Yang; Jing Zhao; Yin-xia Diao; Chen-hui Sun; Mai-He Li (Journal of Mountain Science, 2022)

SYL3-k increases style length and yield of F1 seeds via enhancement of endogenous GA4 content in Oryza sativa L. pistils - Xiaojing Dang; Yuanqing Zhang; Yulong Li; Siqi Chen; Erbao Liu; Bingjie Fang; Qiangming Liu; Dong She; Zhiyao Dong; Zhilan Fan; Dalu Li; Hui Wang; et al. (Theoretical and Applied Genetics, 2022)
Key message SYL3-k allele increases the outcrossing rate of male sterile line and the yield of hybrid F 1 seeds via enhancement of endogenous GA 4 content in Oryza sativa L. pistils. The change in style length might be an adaptation of rice cultivation from south to north in the northern hemisphere. Abstract The style length (SYL) in rice is one of the major factors influencing the stigma exertion, which affects the outcross rate of male sterile line and the yield of hybrid F 1 seeds. However, the biological mechanisms underlying SYL elongation remain elusive. Here, we report a map-based cloning and characterisation of the allele qSYL3-k . The qSYL3-k allele encodes a MADS-box family transcription factor, and it is expressed in various rice organs. The qSYL3-k allele increases SYL via the elongation of cell length in the style, which is associated with a higher GA 4 content in the pistil. The expression level of OsGA3ox2 in pistils with qSYL3-k alleles is significantly higher than that in pistils with qSYL3-n allele on the same genome background of Nipponbare. The yield of F 1 seeds harvested from plants with 7001S SYL3−k alleles was 16% higher than that from plants with 7001S SYL3−n allele. The sequence data at the qSYL3 locus in 136 accessions showed that alleles containing the haplotypes qSYL3 AA , qSYL3 AG , and qSYL3 GA increased SYL, whereas those containing the haplotype qSYL3 GG decreased it. The frequency of the haplotype qSYL3 GG increases gradually from the south to north in the northern hemisphere. These findings will facilitate improvement in SYL and yield of F 1 seeds henceforward.

Analysis of equivalent thickness of geological media for lab-scale study of radon exhalation - Changshou Hong; Yini Yang; Hong Wang; Yong Liu; Xiangyang Li; Bo Lei; Ming Lan; Yifan Chen; Xingwang Dai (Environmental Science and Pollution Research, 2022)

Deep learning model based on big data for water source discrimination in an underground multiaquifer coal mine - Chunlu Jiang; Saijun Zhu; Hong Hu; Shikai An; Wei Su; Xing Chen; Chang Li; Liugen Zheng (Bulletin of Engineering Geology and the Environment, 2022)

Characterization and Cys-directed mutagenesis of urate oxidase from Bacillus subtilis BS04 - Tong-tong Zhu; Hong-na Chen; Lei Yang; Ying-bao Liu; Wei Li; Wen-xiu Sun (Biologia, 2022)

Comparative analysis of chemical constituents and bioactivities of the extracts from leaves, seed coats and embryoids of Ginkgo biloba L. - Xuanxuan Chen; Wu Zhong; Changqing Shu; Hong Yang; Erhu Li (Natural Product Research, 2021)

Antioxidant CPA-type indole alkaloids produced from the deep-sea derived fungus Aspergillus sp. SCSIO 41024 - Wei-Hao Chen; Kun-Long Li; Xiu-Ping Lin; Sheng-Rong Liao; Bin Yang; Xue-Feng Zhou; Jun-Jian Wang; Yong-Hong Liu; Jun-Feng Wang (Natural Product Research, 2021)

Standard litterbags underestimate early-stage lower-order root decomposition rate in a subtropical forest, China - Guan-tao Chen; Yu-qin Chen; Yong Peng; Hong-ling Hu; Jiu-long Xie; Gang Chen; Yin-long Xiao; Li Liu; Yi Tang; Li-hua Tu (Plant and Soil, 2021)

Sigma-1 Receptor Activation Suppresses Microglia M1 Polarization via Regulating Endoplasmic Reticulum–Mitochondria Contact and Mitochondrial Functions in Stress-Induced Hypertension Rats - Kokwin Ooi; Li Hu; Yi Feng; Chenzhi Han; Xiaorong Ren; Xinyi Qian; Haofeng Huang; Sijia Chen; Qi Shi; Hong Lin; Jijiang Wang; Danian Zhu; et al. (Molecular Neurobiology, 2021)

Hydrogen Sulfide Maintains Good Nutrition and Delays Postharvest Senescence in Postharvest Tomato Fruits by Regulating Antioxidative Metabolism - Ting-Ying Zhong; Gai-Fang Yao; Sha-Sha Wang; Ting-Ting Li; Ke-Ke Sun; Jun Tang; Zhong-Qin Huang; Feng Yang; Yan-Hong Li; Xiao-Yan Chen; Lan-Ying Hu; Hua Zhang; et al. (Journal of Plant Growth Regulation, 2021)

Hyper-SUMOylation of SMN induced by SENP2 deficiency decreases its stability and leads to spinal muscular atrophy-like pathology - Yuhong Zhang; Xu Chen; Qiqi Wang; Congcong Du; Wenbin Lu; Hong Yuan; Zhenzhen Zhang; Danqing Li; Xing Ling; Xiang Ren; Yang Zhao; Qi Su; et al. (Journal of Molecular Medicine, 2021)

Deterioration Characteristics of Pre-flawed Granites Subjected to Freeze-Thaw Cycles and Compression - Chen Qiao; Yu Wang; Yong-jie Tong; He-ping Yang; Chang-hong Li; C. Qiao (Geotechnical and Geological Engineering, 2021)

Identification and expression analysis of cobia (Rachycentron canadum) liver-related miRNAs under hypoxia stress - Jian-sheng Huang; Hong-juan Li; Zhi-xiong Guo; Jian-dong Zhang; Wei-zheng Wang; Zhong-liang Wang; Eric Amenyogbe; Gang Chen (Fish Physiology and Biochemistry, 2021)

External evaluation of published population pharmacokinetic models of polymyxin B - Ya-qian Li; Kai-feng Chen; Jun-jie Ding; Hong-yi Tan; Nan Yang; Ya-qi Lin; Cui-fang Wu; Yue-liang Xie; Guo-ping Yang; Jing-Jing Liu; Qi Pei (European Journal of Clinical Pharmacology, 2021)

Astaxanthin Ameliorates Blood Pressure in Salt-Induced Prehypertensive Rats Through ROS/MAPK/NF-κB Pathways in the Hypothalamic Paraventricular Nucleus - Hong-Li Gao; Xiao-Jing Yu; Yan Zhang; Chen-Long Wang; Yi-Ming Lei; Jia-Yue Yu; Dong-Miao Zong; Kai-Li Liu; Dong-Dong Zhang; Ying Li; Hua Tian; Nian-Ping Zhang; et al. (Cardiovascular Toxicology, 2021)

Development and characterization of SNP markers in many-lined sun skink (Eutropis multifasciata) from transcriptomic sequences - Youfu Lin; Zijin Qian; Shiyu Shen; Yicheng Huang; Yu Du; Hong Li; Lian Chen (Conservation Genetics Resources, 2021)

Identification and antimicrobial properties of a new alkaloid produced by marine-derived Verrucosispora sp. FIM06-0036 - Ming-Hong Chen; Yun-Yang Lian; Dong-Sheng Fang; Li Chen; Jia Jia; Wen-Long Zhang; Ru Lin; Yang Xie; Hong-Kai Bi; Hong Jiang (Natural Product Research, 2021)

A new framework for the identification of flash drought: Multivariable and probabilistic statistic perspectives - Chen Hu; Jun Xia; Dunxian She; Lingcheng Li; Zhihong Song; Si Hong (International Journal of Climatology, 2021)
Flash drought is distinguished with seasonal drought by its characteristics of sudden onset and rapid intensification, and has attracted increasing concern due to the severe negative impacts on socioeconomic development and ecosystems. To accurate identify the onset time and propagation of flash drought is still a big challenge, as it is influenced by many factors (e.g., deficit in precipitation, increase in evapotranspiration and temperature, shortage in soil moisture, and etc.). This study aims to develop a probabilistic and multivariable flash drought identification method (PMFDI) from the perspective of considering the interaction effects from different driving factors on flash drought occurrence and propagation with a multivariable statistical tool. The PMFDI uses the weekly standardized precipitation evapotranspiration index and the standardized soil moisture index to describe the abnormally changes in multiple hydrometeorological variables over a short duration. The linearly multivariable index (LMI) is employed to describe the correlation relationship between multiple hydrometeorological variables and to identify flash droughts from the aspects of sudden onset and rapid intensification. We select the Loess Plateau (LP) in China to verify the efficiency of the developed PMFDI with the comparison to the other two recently proposed flash drought identification methods. The results indicate that PMFDI can identify high‐ and low‐ frequency regions similar to those identified by the other two methods and can generally recognize actual flash droughts. In addition, the PMFDI can capture the comprehensive impact of multiple hydrometeorological variables as well as their interaction on flash drought occurrence, which provides a useful perspective to understand the propagation processes of the actual flash droughts in the LP.

Three new diterpenoids from Euphorbia peplus - Yan-Ni Chen; Qing-Yun Lu; Dong-Mei Li; Ying-Yao Li; Xue-Xue Pu; Bo-Ting Li; Xiao-Han Tang; Hong-Yu Tang; Shuai Liu; Lei Yang; Yu Zhang; Ying-Tong Di; et al. (Natural Product Research, 2021)

Three new dimeric 2-(2-phenylethyl)chromones from artificial agarwood of Aquilaria sinensis - Pan Xiang; Wen-Hua Dong; Cai-Hong Cai; Wei Li; Li-Man Zhou; Hao-Fu Dai; Hui-Qin Chen; Wen-Li Mei (Natural Product Research, 2021)

Time-resolved Fluorescence Immunoassay (TRFIA) for the Simultaneous Detection of MMP-9 and Lp-PLA2 in Serum - Hong-yan Ma; Qian Mao; Yan-bin Zhu; Chun-li Cong; Shi-yu Zheng; Qi Zhang; Cui-cui Chen; Lai-qing Li (Journal of Fluorescence, 2021)

Transcriptomic responses of haloalkalitolerant bacterium Egicoccus halophilus EGI 80432T to highly alkaline stress - Dai-Di Chen; Manzoor Ahmad; Yong-Hong Liu; Shuang Wang; Bing-Bing Liu; Shu-Xian Guo; Hong-Chen Jiang; Wen-Sheng Shu; Wen-Jun Li (Extremophiles, 2021)

Mutation of the sixth amino acid of the Rep protein has no effect on porcine circovirus 2b but enhances porcine circovirus 2d replication in vitro - Xiaoyan Wu; Shuo Wang; Changxun Xin; Chen Li; Jianli Shi; Zhe Peng; Chang Liu; Hong Han; Ying Yang; Yao Tian; Jiaxin Li; Shaojian Xu; et al. (Archives of Virology, 2021)

A new ergostane derivative from the leaves of Heynea trijuga Roxburgh - Shou-Bai Liu; Zheng Cui; Hui-Qin Chen; Hao Wang; Wen-Hua Dong; Cai-Hong Cai; Wen-Li Mei; Hao-Fu Dai (Natural Product Research, 2021)

A monthly night-time light composite dataset of NOAA-20 in China: a multi-scale comparison with S-NPP - Yuchen Hong; Bin Wu; Zhichao Song; Yangguang Li; Qiusheng Wu; Zuoqi Chen; Shaoyang Liu; Chengshu Yang; Jianping Wu; Bailang Yu (International Journal of Remote Sensing, 2021)

Peripheral CD4+ T cell signatures in predicting the responses to anti-PD-1/PD-L1 monotherapy for Chinese advanced non-small cell lung cancer - Liliang Xia; Hui Wang; Mingjiao Sun; Yi Yang; Chengcheng Yao; Sheng He; Huangqi Duan; Weimin Xia; Ruiming Sun; Yaxian Yao; Zhiwei Chen; Qiong Zhao; et al. (Science China Life Sciences, 2021)

An atlas of CNV maps in cattle, goat and sheep - Yongzhen Huang; Yunjia Li; Xihong Wang; Jiantao Yu; Yudong Cai; Zhuqing Zheng; Ran Li; Shunjin Zhang; Ningbo Chen; Hojjat Asadollahpour Nanaei; Quratulain Hanif; Qiuming Chen; et al. (Science China Life Sciences, 2021)

Cloning of Mn-SOD gene and its mRNA expression difference and antioxidant enzyme activities under hypoxia stress of cobia Rachycentron canadum - Jian-Dong Zhang; Hong-Juan Li; Eric Amenyogbe; Wei-Zheng Wang; Jian-Sheng Huang; Gang Chen (Molecular Biology Reports, 2021)

Emerging role of air pollution in chronic kidney disease - Yue Chen; Fan Cao; Jian-Ping Xiao; Xin-Yu Fang; Xue-Rong Wang; Li-Hong Ding; De-Guang Wang; Hai-Feng Pan (Environmental Science and Pollution Research, 2021)

Regional brain network and behavioral alterations in EGR3 gene transfected rat model of schizophrenia - Wenwen Gao; Guangfei Li; Xiaowei Han; Zeyu Song; Shuai Zhao; Feiyi Sun; Hong Ma; Ailing Cui; Yige Wang; Xiuxiu Liu; Yue Chen; Lu Zhang; et al. (Brain Imaging and Behavior, 2021)

Aberrant activity within auditory network is associated with psychiatric comorbidities in interictal migraineurs without aura - Heng-Le Wei; Yu-Chen Chen; Yu-Sheng Yu; Xi Guo; Gang-Ping Zhou; Qing-Qing Zhou; Li-Jie Qu; Xindao Yin; Junrong Li; Hong Zhang (Brain Imaging and Behavior, 2021)

Identification of a phage-derived depolymerase specific for KL64 capsule of Klebsiella pneumoniae and its anti-biofilm effect - Min Li; Pei Li; Long Chen; Genglin Guo; Yuyi Xiao; Liang Chen; Hong Du; Wei Zhang (Virus Genes, 2021)

Shifting roles of the East China Sea in the phylogeography of red nanmu in East Asia - Kai Jiang; Xin Tong; Yan‐Qian Ding; Zheng‐Wei Wang; Li‐Yuan Miao; Yue‐E Xiao; Wei‐Chang Huang; Yong‐Hong Hu; Xiao‐Yong Chen (Journal of Biogeography, 2021)
Aim The effect of eustasy driven by climatic oscillations on species diversification across the East China Sea (ECS) remains unclear. In this study, Machilus thunbergii (红楠, red nanmu in Chinese) was used as a model species to determine whether the ECS acted as either a “species pump” or “species vacuum” during the Pleistocene. Locations Eastern China, and southern and central Japan. Taxon Lauraceae. Methods Ecological niche modelling was employed to predict the potential distribution of M . thunbergii during the Last Glacial Maximum (LGM) and the last interglacial period. Nuclear microsatellite and chloroplast markers were used to reveal the phylogeographic pattern and infer the population history of 33 M . thunbergii populations. Results The ecological niche models suggested that the ECS provided potentially suitable habitats for M. thunbergii during the LGM. A sharp change in cpDNA haplotypes was found along the eastern China coasts, while microsatellites revealed a clinal pattern for genetic composition from eastern China to central Japan. The divergent lineages formed an admixture on the Zhoushan Archipelago of China and Kyushu Island of Japan. The estimated divergent and admixture times were c . 68 kyr and c . 15 kyr, corresponding to the periods where there were rising sea levels after the MIS4 glaciation and falling sea levels during the LGM, respectively. Main conclusions Machilus thunbergii probably underwent alternating population isolation during interglacial periods and connection during glacial maxima across the ECS, but such periodicity of isolation and connection seems not to have promoted diversification as suggested by the species pump hypothesis. Incipient divergence has been periodically wiped out due to frequent coalescence, rendering the ECS more like a “species vacuum”, particularly for species with relatively long generation lengths.

A review on the removal of heavy metals and metalloids by constructed wetlands: bibliometric, removal pathways, and key factors - Guanlong Yu; Peiyuan Li; Guoliang Wang; Jianwu Wang; Yameng Zhang; Shitao Wang; Kai Yang; Chunyan Du; Hong Chen (World Journal of Microbiology and Biotechnology, 2021)

Pinocembrin Promotes OPC Differentiation and Remyelination via the mTOR Signaling Pathway - Qi Shao; Ming Zhao; Wenwen Pei; Yingyan Pu; Mingdong Liu; Weili Liu; Zhongwang Yu; Kefu Chen; Hong Liu; Benqiang Deng; Li Cao (Neuroscience Bulletin, 2021)

Apigenin Improves Hypertension and Cardiac Hypertrophy Through Modulating NADPH Oxidase-Dependent ROS Generation and Cytokines in Hypothalamic Paraventricular Nucleus - Hong-Li Gao; Xiao-Jing Yu; Han-Bo Hu; Qian-Wen Yang; Kai-Li Liu; Yan-Mei Chen; Yan Zhang; Dong-Dong Zhang; Hua Tian; Guo-Qing Zhu; Jie Qi; Yu-Ming Kang (Cardiovascular Toxicology, 2021)

A novel anellovirus from hospitalized neonates - Hong Li; Yuqing Xiao; Heteng Zhang; Xu Chen; Jinquan Lv; Shixing Yang; Hongyan Lu; Wen Zhang (Archives of Virology, 2021)

Effects of ultrasound on functional properties, structure and glycation properties of proteins: a review - Derong Lin; Qiuting Zhang; Lijuan Xiao; Yichen Huang; Zhengfang Yang; Zhijun Wu; Zongcai Tu; Wen Qin; Hong Chen; Dingtao Wu; Qing Zhang; Suqing Li (Critical Reviews in Food Science and Nutrition, 2021)

Modulation of the 5-HT 3 A receptor current by desacylbaldrinal - Li-Xia Wang; Hu-Lan Chen; Hong-Ling Yan; Fei Tang; Hai Zhang; Hong-Xiang Li; Qiang Ye; Cheng Peng; Yu-Zhu Tan (Natural Product Research, 2021)

Two new species of Amanita section Roanokenses with a radicating basal bulb - Juan Zhong; Gui-Wu Li; Jin-Bao Pu; Zuo-Hong Chen; Ping Zhang (Mycological Progress, 2021)

Application of Plant Print Identification Technology in Salt-resistant Soybean Breeding - Yan Li; Xia Li; Zi-qi Chen; Ying Ma; Guang-yu Yang; Ying Zhang; Ming-chun Sun; Li-hong Zhang; Jin-meng Chu; Jing-mei Lu; Jun Zhu; Ji-hong You (Journal of Plant Growth Regulation, 2021)

Overexpression of Cell-Surface Marker SLC16A1 Shortened Survival in Human High-Grade Gliomas - Hong-Han Lin; Wen-Chiuan Tsai; Chia-Kuang Tsai; Ssu-Han Chen; Li-Chun Huang; Dueng-Yuan Hueng; Kuang-Chen Hung (Journal of Molecular Neuroscience, 2021)

Application of Extension Theory Based on Improved Entropy Weight Method to Rock Slope Analysis in Cold Regions - Chen Qiao; Yu Wang; Chang-hong Li; Bing-qian Yan (Geotechnical and Geological Engineering, 2021)

Maternal exposure to sulfur dioxide and the risk of oral clefts in Liaoning Province, China: a population-based case-control study - Fang-Hua Liu; Ze Xing; Ting-Ting Gong; Jia-Yu Zhang; Yan-Hong Huang; Jing Li; Shu Liu; Yan-Ling Chen; Li-Li Li; Cheng-Zhi Jiang; Zong-Jiao Chen; Yu-Hong Zhao; et al. (Environmental Science and Pollution Research, 2021)

Association between population density and infection rate suggests the importance of social distancing and travel restriction in reducing the COVID-19 pandemic - Heliang Yin; Tong Sun; Lan Yao; Yan Jiao; Li Ma; Lin Lin; J Carolyn Graff; Lotfi Aleya; Arnold Postlethwaite; Weikuan Gu; Hong Chen (Environmental Science and Pollution Research, 2021)

The correlation of altitude with gingival status among adolescents in western China: a cross-sectional study - Zhiwu Wu; Rui Zhang; Li Cheng; Ruilie Cai; Hong Chen; Ran Cheng; Tao Hu (Environmental Geochemistry and Health, 2021)

Correction to: High-Dose Aluminum Exposure Further Alerts Immune Phenotype in Aplastic Anemia Patients - Yao Zuo; Xiang Lu; Xiaochao Wang; Suren R. Sooranna; Liju Tao; Shiqiang Chen; Hongwen Li; Dan Huang; Guanye Nai; Hong Chen; Chunfeng Pan; Caihong Huang; et al. (Biological Trace Element Research, 2021)
The article High-Dose Aluminum Exposure Further Alerts Immune Phenotype in Aplastic Anemia Patients, written by Yao Zuo, Xiang Lu, Xiaochao Wang, Suren R. Sooranna, Liju Tao, Shiqiang Chen, Hongwen Li, Dan Huang, Guanye Nai, Hong Chen, Chunfeng Pan, Caihong Huang and Yanmin Pang.

The rescue and selection of thermally stable type O vaccine candidate strains of foot-and-mouth disease virus - Ya Gao; Pinghua Li; Xueqing Ma; Xingwen Bai; Pu Sun; Ping Du; Hong Yuan; Yimei Cao; Kun Li; Yuanfang Fu; Jing Zhang; Huifang Bao; et al. (Archives of Virology, 2021)

A novel lymphatic pattern promotes metastasis of cervical cancer in a hypoxic tumour-associated macrophage-dependent manner - Xiao-Jing Chen; Wen-Fei Wei; Zi-Ci Wang; Nisha Wang; Chu-Hong Guo; Chen-Fei Zhou; Luo-Jiao Liang; Sha Wu; Li Liang; Wei Wang (Angiogenesis, 2021)
Lymphatic remodelling in the hypoxic tumour microenvironment (TME) is critically involved in the metastasis of cervical squamous cell carcinoma (CSCC); however, its underlying mechanisms remain unclear. Here, we uncovered a novel lymphatic pattern in the hypoxic TME, wherein lymphatic vessels (LVs) are encapsulated by tumour-associated macrophages (TAMs) to form an interconnected network. We describe these aggregates as LVEM (LVs encapsulated by TAMs) considering their advantageous metastatic capacity and active involvement in early lymph node metastasis (LNM). Mechanistic investigations revealed that interleukin-10 (IL-10) derived from hypoxic TAMs adjacent to LVs was a prerequisite for lymphangiogenesis and LVEM formation through its induction of Sp1 upregulation in lymphatic endothelial cells (LECs). Interestingly, Sp1 high LECs promoted the transactivation of C–C motif chemokine ligand 1 (CCL1) to facilitate TAM and tumour cell recruitment, thereby forming a positive feedback loop to strengthen the LVEM formation. Knockdown of Sp1 or blockage of CCL1 abrogated LVEM and consequently attenuated LNM. Notably, CSCC non-LNM is largely devoid of hypoxic TAMs and the resultant LVEM, which might explain its metastatic delay. These findings identify a novel and efficient metastasis-promoting lymphatic pattern in the hypoxic TME, which might provide new targets for anti-metastasis therapy and prognostic assessment.

Neuroprotective triterpene saponins from the leaves of Panax notoginseng - Ji-Wu Huang; Yi-Qian Du; Chuang-Jun Li; Jing-Zhi Yang; Jie Ma; Ying-Da Zang; Nai-Hong Chen; Dong-Ming Zhang (Natural Product Research, 2021)

Three new 5,6,7,8-tetrahydro-2-(2-phenylethyl)chromones and one new dimeric 2-(2-phenylethyl)chromone from agarwood of Aquilaria crassna Pierre ex Lecomte in Laos - Yang-Mei Zhao; Li Yang; Fan-Dong Kong; Wen-Hua Dong; Wei Li; Hui-Qin Chen; Hao Wang; Cai-Hong Cai; Cui-Juan Gai; Wen-Li Mei; Hao-Fu Dai (Natural Product Research, 2021)

The distribution of liver cancer stem cells correlates with the mechanical heterogeneity of liver cancer tissue - Yuchuan Sun; Hong Li; Qiufang Chen; Qing Luo; Guanbin Song (Histochemistry and Cell Biology, 2021)

Capacity of transportation and spread of COVID-19—an ironical fact for developed countries - Li Ma; Zhuo Yu; Yan Jiao; Lin Lin; Wei Zhong; Sara W. Day; Arnold Postlethwaite; Hong Chen; Qiang Li; Heliang Yin; Gang Wang (Environmental Science and Pollution Research, 2021)

Hydrogeochemical Evolution Mechanism of Carbonate Geothermal Water in Southwest China - Zhengshan Chen; Lijun Zhu; Pu Liu; Chao Li; Yanan Zhou; YongKang Li; Hong Xie; Tong Xiang (Arabian Journal of Geosciences, 2021)

Holocene sea level trend on the west coast of Bohai Bay, China: reanalysis and standardization - Jianfen Li; Zhiwen Shang; Fu Wang; Yongsheng Chen; Lizhu Tian; Xingyu Jiang; Qian Yu; Hong Wang (Acta Oceanologica Sinica, 2021)

Design and Application of an In Situ Test Device for Rheological Characteristic Measurements of Liquefied Submarine Sediments - Hong Zhang; Xiaolei Liu; Anduo Chen; Weijia Li; Yang Lu; Xingsen Guo (Journal of Marine Science and Engineering, 2021)
Liquefied submarine sediments can easily lead to submarine landslides and turbidity currents, and cause serious damage to offshore engineering facilities. Understanding the rheological characteristics of liquefied sediments is critical for improving our knowledge of the prevention of submarine geo-hazards and the evolution of submarine topography. In this study, an in situ test device was developed to measure the rheological properties of liquefied sediments. The test principle is the shear column theory. The device was tested in the subaqueous Yellow River delta, and the test results indicated that liquefied sediments can be regarded as “non-Newtonian fluids with shear thinning characteristics”. Furthermore, a laboratory rheological test was conducted as a contrast experiment to qualitatively verify the accuracy of the in situ test data. Through the comparison of experiments, it was proved that the use of the in situ device in this paper is suitable and reliable for the measurement of the rheological characteristics of liquefied submarine sediments. Considering the fact that liquefaction may occur in deeper water (>5 m), a work pattern for the device in the offshore area is given. This novel device provides a new way to test the undrained shear strength of liquefied sediments in submarine engineering.

Bioactive polyketides from the pathogenic fungus of Epicoccum sorghinum - Ching-Chia Chang; Chi-Ying Li; Yi-Hong Tsai; Mohamed El-Shazly; Chien-Kei Wei; Zih-Jie Yang; Shu-Li Chen; Chin-Chung Wu; Yang-Chang Wu; Fang-Rong Chang (Planta, 2021)

Genetic Architecture of Childhood Kidney and Urological Diseases in China - Ye Fang; Hua Shi; Tianchao Xiang; Jiaojiao Liu; Jialu Liu; Xiaoshan Tang; Xiaoyan Fang; Jing Chen; Yihui Zhai; Qian Shen; Guomin Li; Li Sun; et al. (Phenomics, 2021)
Kidney disease is manifested in a wide variety of phenotypes, many of which have an important hereditary component. To delineate the genotypic and phenotypic spectrum of pediatric nephropathy, a multicenter registration system is being implemented based on the Chinese Children Genetic Kidney Disease Database (CCGKDD). In this study, all the patients with kidney and urological diseases were recruited from 2014 to 2020. Genetic analysis was conducted using exome sequencing for families with multiple affected individuals with nephropathy or clinical suspicion of a genetic kidney disease owing to early-onset or extrarenal features. The genetic diagnosis was confirmed in 883 of 2256 (39.1%) patients from 23 provinces in China. Phenotypic profiles showed that the primary diagnosis included steroid-resistant nephrotic syndrome (SRNS, 23.5%), glomerulonephritis (GN, 32.2%), congenital anomalies of the kidney and urinary tract (CAKUT, 21.2%), cystic renal disease (3.9%), renal calcinosis/stone (3.6%), tubulopathy (9.7%), and chronic kidney disease of unknown etiology (CKDu, 5.8%). The pathogenic variants of 105 monogenetic disorders were identified. Ten distinct genomic disorders were identified as pathogenic copy number variants (CNVs) in 11 patients. The diagnostic yield differed by subgroups, and was highest in those with cystic renal disease (66.3%), followed by tubulopathy (58.4%), GN (57.7%), CKDu (43.5%), SRNS (29.2%), renal calcinosis /stone (29.3%) and CAKUT (8.6%). Reverse phenotyping permitted correct identification in 40 cases with clinical reassessment and unexpected genetic conditions. We present the results of the largest cohort of children with kidney disease in China where diagnostic exome sequencing was performed. Our data demonstrate the utility of family-based exome sequencing, and indicate that the combined analysis of genotype and phenotype based on the national patient registry is pivotal to the genetic diagnosis of kidney disease.

Mapping Domain- and Age-Specific Functional Brain Activity for Children’s Cognitive and Affective Development - Lei Hao; Lei Li; Menglu Chen; Jiahua Xu; Min Jiang; Yanpei Wang; Linhua Jiang; Xu Chen; Jiang Qiu; Shuping Tan; Jia-Hong Gao; Yong He; et al. (Neuroscience Bulletin, 2021)

RNA-Seq Transcriptome Analysis of the Liver and Brain of the Black Carp (Mylopharyngodon piceus) During Fasting - Ya-Fan Dai; Yu-bang Shen; Shen-Tong Wang; Jia-Hua Zhang; Yu-Hong Su; Sheng-Chen Bao; Xiao-Yan Xu; Jia-Le Li (Marine Biotechnology, 2021)

Performance of VITEK 2, E-test, Kirby–Bauer disk diffusion, and modified Kirby–Bauer disk diffusion compared to reference broth microdilution for testing tigecycline susceptibility of carbapenem-resistant K. pneumoniae and A. baumannii in a multicenter study in China - Dandan Yin; Yan Guo; Min Li; Wenjuan Wu; Jin Tang; Ying Liu; Feng Chen; Yuxing Ni; Jingyong Sun; Hong Zhang; Hu Zhao; Fupin Hu (European Journal of Clinical Microbiology & Infectious Diseases, 2021)

Proton Pump Inhibitor Exposure and Acute Myocardial Infarction Risk: A Nested Cohort Study - Hsiang-Jung Tseng; Chih-Ming Cheng; Shih-Jen Tsai; Wei-Chen Lin; Ya-Mei Bai; Chia-Fen Tsai; Tung-Ping Su; Cheng-Ta Li; Tzeng-Ji Chen; Mu-Hong Chen (Cardiovascular Toxicology, 2021)

Effect of fine particle content on mechanical properties of tailings under high confining pressure - Qian Bi; Chang-hong Li; Jun-xin Chen (Arabian Journal of Geosciences, 2021)

Ground roll separation method via threshold filtering and constraint of seismic wavelet support in curvelet domain - De-ying Wang; Li-hua Chen; Lie-qian Dong; Li-hong Zhao; Ren-wei Ding; Cheng-zhen Ding (Applied Geophysics, 2021)

Structural and functional organization of the MYC transcriptional factors in Camellia sinensis - Sangtian Chen; Yaze Kong; Xueying Zhang; Zhenfeng Liao; Yuqing He; Linying Li; Zongsuo Liang; Qing Sheng; Gaojie Hong (Planta, 2021)

Overexpression of ring finger protein 20 inhibits the progression of liver fibrosis via mediation of histone H2B lysine 120 ubiquitination - Shanshan Chen; Xuan Dai; Hong Li; Yuhan Gong; Yueyue Zhao; Haijun Huang (Human Cell, 2021)

High-Dose Aluminum Exposure Further Alerts Immune Phenotype in Aplastic Anemia Patients - Yao Zuo; Xiang Lu; Xiaochao Wang; Suren R. Sooranna; Liju Tao; Shiqiang Chen; Hongwen Li; Dan Huang; Guanye Nai; Hong Chen; Chunfeng Pan; Caihong Huang; et al. (Biological Trace Element Research, 2021)
This study explored the relationship between immunological status and clinical characteristics of aplastic anemia (AA) patients to plasma aluminum levels, which were increased after constant exposure to high levels of this metal. Sixty-two AA patients (33 cases with high and 29 cases with low or no exposure to aluminum) and 30 healthy controls were selected for this study. Aluminum in human albumin solution was measured by inductivity coupled plasma mass spectrometry. IL-10, IL-12, IL-17, and INF-γ levels were measured by enzyme-linked immunosorbent assay. The distribution of lymphocyte subsets were determined by flow cytometry. The expression levels of immunoglobulins and complement C3 and C4 were also measured. Exposure to high aluminum raised the levels of serum aluminum in AA patients ( P < 0.01). The levels of hemoglobin and complement C4 were lower in AA patients with high aluminum exposure ( P < 0.05 and < 0.01, respectively). The percentage of CD4 + T cells and the ratio of CD4 + / CD8 + T cells in peripheral blood in AA patients with high aluminum exposure were higher compared with control AA patients ( P < 0.05 in both cases), while the percentage of CD8 + T cells was significantly lower than that in non-aluminum–exposed AA patients ( P < 0.05). Compared with non-aluminum–exposed AA patients, the level of IL-10 in the high aluminum–exposed AA group was significantly higher ( P < 0.05 in both cases). The immunological and clinical characteristics of AA patients from regions of high aluminum exposure are different to those in from non-aluminum areas. These results suggest that high aluminum exposure alters the immune system in patients suffering from AA.

Lithological and environmental controls on large tafoni along conglomerate cliffs in subtropic humid Danxiashan UNESCO Global Geopark - Xin Chen; Liu-qin Chen; Yan-hong Zhang; Ding-ding Du; Hai-ping Hu; Dong-xing Liu; Wen-zhuo Li (Journal of Mountain Science, 2021)

Exogenous ABA and its inhibitor regulate flower bud induction of apple cv. ‘Nagafu No. 2′ grafted on different rootstocks - Wen-Fang Li; Juan Mao; Jing Su; Xin-Wen Li; Mohammed Mujitaba Dawuda; Zong-Huan Ma; Cun-Wu Zuo; Ze-Shan An; Bai-Hong Chen (Trees, 2021)

Subcellular Localization of the D27 Protein in Sugarcane (Saccharum spp. Hybrids) Using an Optimized Protoplast Isolation, Purification, and Transient Gene Expression Protocol - Zhuan-di Wu; Xin Hu; Feng-gang Zan; Yong-bao Pan; David M. Burner; Zheng-ying Luo; Jia-yong Liu; Li-ping Zhao; Li Yao; Yong Zhao; Xin-long Liu; Hong-ming Xia; et al. (Sugar Tech, 2021)

DeepMapi: a Fully Automatic Registration Method for Mesoscopic Optical Brain Images Using Convolutional Neural Networks - Hong Ni; Zhao Feng; Yue Guan; Xueyan Jia; Wu Chen; Tao Jiang; Qiuyuan Zhong; Jing Yuan; Miao Ren; Xiangning Li; Hui Gong; Qingming Luo; et al. (Neuroinformatics, 2021)
The extreme complexity of mammalian brains requires a comprehensive deconstruction of neuroanatomical structures. Scientists normally use a brain stereotactic atlas to determine the locations of neurons and neuronal circuits. However, different brain images are normally not naturally aligned even when they are imaged with the same setup, let alone under the differing resolutions and dataset sizes used in mesoscopic imaging. As a result, it is difficult to achieve high-throughput automatic registration without manual intervention. Here, we propose a deep learning-based registration method called DeepMapi to predict a deformation field used to register mesoscopic optical images to an atlas. We use a self-feedback strategy to address the problem of imbalanced training sets (sampling at a fixed step size in nonuniform brains of structures and deformations) and use a dual-hierarchical network to capture the large and small deformations. By comparing DeepMapi with other registration methods, we demonstrate its superiority over a set of ground truth images, including both optical and MRI images. DeepMapi achieves fully automatic registration of mesoscopic micro-optical images, even macroscopic MRI datasets, in minutes, with an accuracy comparable to those of manual annotations by anatomists.

The Roles of Epinephelus coioides miR-122 in SGIV Infection and Replication - Hong-Yan Sun; Yu-Ling Su; Pin-Hong Li; Jia-Yang He; He-Jia Chen; Gang Wang; Shao-Wen Wang; Xiao-Hong Huang; You-Hua Huang; Qi-Wei Qin (Marine Biotechnology, 2021)
In mammals, mature miR-122 is 22 nucleotides long and can be involved in regulating a variety of physiological and biological pathways. In this study, the expression profile and effects of grouper Epinephelus coioides miR-122 response to Singapore grouper iridovirus (SGIV) infection were investigated. The sequences of mature microRNAs (miRNAs) from different organisms are highly conserved, and miR-122 from E. coioides exhibits high similarity to that from mammals and other fish. The expression of miR-122 was up-regulated during SGIV infection. Up-regulation of miR-122 could significantly enhance the cytopathic effects (CPE) induced by SGIV, the transcription levels of viral genes (MCP, VP19, LITAF and ICP18), and viral replication; reduce the expression of inflammatory factors (TNF-a, IL-6, and IL-8), and the activity of AP-1 and NF-κB, and miR-122 can bind the target gene p38α MAPK to regulate the SGIV-induced cell apoptosis and the protease activity of caspase-3. The results indicated that SGIV infection can up-regulate the expression of E. coioides miR-122, and up-regulation of miR-122 can affect the activation of inflammatory factors, the activity of AP-1 and NF-κB, and cell apoptosis to regulate viral replication and proliferation.

Dissipation behavior, residue dynamics, and dietary risk assessment of forchlorfenuron in postharvest kiwifruits during simulated cold chain logistics and store shelf life - Difeng Zhu; Li Ping; Renyun Qian; Chao Chen; Yawen Hong; Zhenxuan Tong; Xiaochun Yang (Environmental Science and Pollution Research, 2021)

Increased depression risk for elderly women with high blood levels of strontium and barium - Jia Lv; Yan-ling Li; Wen-qiang Ren; Rong Li; Jian-rong Chen; Chao Bao; Zhi-ping Du; Shun Feng; Ling Gu; Hui Gao; Kai-yong Liu; Lin-sheng Yang; et al. (Environmental Chemistry Letters, 2021)

Haplotype networks of Phycocalidia tanegashimensis (Bangiales, Rhodophyta) indicate a probable invasion from the South China Sea to Brazil - Wan Zhao; Lei Dong; Dang Diem Hong; Juliet Brodie; Wei-Zhou Chen; Dam Duc Tien; Wei Zhou; Qin-Qin Lu; Mei-Ru Zhang; Li-En Yang (Marine Biodiversity, 2021)

Polymorphisms in the DC-SIGN gene and their association with the severity of hand, foot, and mouth disease caused by enterovirus 71 - Ya-Ping Li; Mu-Qi Wang; Chen-Rui Liu; Hui-Ling Deng; Yuan Wu; Shuang-Suo Dang; Li-Hong Xu (Archives of Virology, 2021)

Interest-activity symptom severity predicts response to ketamine infusion in treatment-resistant depression - Mu-Hong Chen; Wei-Chen Lin; Hui-Ju Wu; Ya-Mei Bai; Cheng-Ta Li; Shih-Jen Tsai; Chen-Jee Hong; Pei-Chi Tu; Tung-Ping Su (Psychopharmacology, 2021)

Moderate oxidative stress promotes epithelial–mesenchymal transition in the lens epithelial cells via the TGF-β/Smad and Wnt/β-catenin pathways - Xi Chen; Hong Yan; Ying Chen; Guo Li; Yue Bin; Xiyuan Zhou (Molecular and Cellular Biochemistry, 2021)

Thiazole-based and thiazolidine-based protein tyrosine phosphatase 1B inhibitors as potential anti-diabetes agents - Kexin Chen; Xu Yao; Ting Tang; Li-Mei Chen; Can Xiao; Jing-Yi Wang; Hong-Fei Chen; Zhong-Xing Jiang; Yi Liu; Xing Zheng (Medicinal Chemistry Research, 2021)

Efficient Editing of an Adenoviral Vector Genome with CRISPR/Cas9 - Qiang Li; Hui Wang; Chen-yu Gong; Zhao Chen; Jia-xing Yang; Hong-wei Shao; Wen-feng Zhang (Indian Journal of Microbiology, 2021)

Genome surveying reveals the complete chloroplast genome and nuclear genomic features of the crocin-producing plant Gardenia jasminoides Ellis - Wencai Wang; Fengqing Shao; Xin Deng; Yuanwei Liu; Siyun Chen; Yongquan Li; Wei Guo; Qingbin Jiang; Hong Liang; Xianzhi Zhang (Genetic Resources and Crop Evolution, 2021)

Maternal exposure to ambient SO2 and risk of polydactyly and syndactyly: a population-based case-control study in Liaoning Province, China - Yu-Ting Jiang; Ting-Ting Gong; Jia-Yu Zhang; Yan-Hong Huang; Jing Li; Shu Liu; Yan-Ling Chen; Li-Li Li; Cheng-Zhi Jiang; Zong-Jiao Chen; Yu-Hong Zhao; Qi-Jun Wu (Environmental Science and Pollution Research, 2021)

Genetic diversity analysis of Topmouth Culter (Culter alburnus) based on microsatellites and D-loop sequences - Ning Sun; Dong-Mei Zhu; Qing Li; Gui-Ying Wang; Jian Chen; Feifei Zheng; Pei Li; Yan-Hong Sun (Environmental Biology of Fishes, 2021)

Arbuscular mycorrhizal colonization rate of an exotic plant, Galinsoga quadriradiata, in mountain ranges changes with altitude - Gang Liu; Rui-Ling Liu; Wen-Gang Zhang; Ying-Bo Yang; Xiao-Qiong Bi; Ming-Zhu Li; Xiao-Yan Chen; Hua Nie; Zhi-Hong Zhu (Mycorrhiza, 2021)

Measuring solar irradiance profiles in the Arctic sea ice using fiber optic spectrometry via inclined holes - Zexia Qiu; Hangzhou Wang; Tao Li; Hong Song; Yuanqian Wu; Tingting Yan; Ying Chen (Acta Oceanologica Sinica, 2021)

MiR-126-3p-Enriched Extracellular Vesicles from Hypoxia-Preconditioned VSC 4.1 Neurons Attenuate Ischaemia-Reperfusion-Induced Pain Hypersensitivity by Regulating the PIK3R2-Mediated Pathway - He Wang; Feng-Shou Chen; Zai-Li Zhang; Hong-Xu Zhou; Hong Ma; Xiao-Qian Li (Molecular Neurobiology, 2021)

Evaluating the effect of midpalatal corticotomy-assisted rapid maxillary expansion on the upper airway in young adults using computational fluid dynamics - Juan Li; Lingfang Shi; Xiayao Zhang; Luxi Weng; Hong Chen; Jun Lin (Journal of Zhejiang University-SCIENCE B, 2021)

TRIP13 promotes the proliferation and invasion of lung cancer cells via the Wnt signaling pathway and epithelial–mesenchymal transition - Zhi-Han Li; Lei Lei; Liang-Ru Fei; Wen-Jing Huang; Yi-Wen Zheng; Mai-Qing Yang; Zhao Wang; Chen-Chen Liu; Hong-Tao Xu (Journal of Molecular Histology, 2021)

Study on Rock Burst Prediction of Deep Buried Tunnel Based on Cusp Catastrophe Theory - Chen Qiao; Yan-hua Guo; Chang-hong Li (Geotechnical and Geological Engineering, 2021)

Wolbachia and Spiroplasma could influence bacterial communities of the spider mite Tetranychus truncatus - Kun Yang; Han Chen; Xiao-Li Bing; Xue Xia; Yu-Xi Zhu; Xiao-Yue Hong (Experimental and Applied Acarology, 2021)

Research progress and hot spots of hydrothermal liquefaction for bio-oil production based on bibliometric analysis - Jian Yang; Chen Hong; Yi Xing; Zixuan Zheng; Zaixing Li; Xiumei Zhao; Chenhao Qi (Environmental Science and Pollution Research, 2021)

Effects of perceived value on green consumption intention based on double-entry mental accounting: taking energy-efficient appliance purchase as an example - Ting Yue; Junli Liu; Ruyin Long; Hong Chen; Qianwen Li; Haiwen Liu; Yu Gu (Environmental Science and Pollution Research, 2021)

Quantitatively determine the dominant driving factors of the spatial—temporal changes of vegetation NPP in the Hengduan Mountain area during 2000–2015 - Shu-ting Chen; Bing Guo; Rui Zhang; Wen-qian Zang; Cui-xia Wei; Hong-wei Wu; Xiao Yang; Xiao-yan Zhen; Xing Li; Da-fu Zhang; Bao-min Han; Hai-ling Zhang (Journal of Mountain Science, 2021)

Detection and genetic characteristics of porcine bocavirus in central China - Lan-Lan Zheng; Jian-Tao Cui; Han Qiao; Xin-Sheng Li; Xiao-Kang Li; Hong-Ying Chen (Archives of Virology, 2021)

Improvement of Soil Moisture Simulation in Eurasia by the Beijing Climate Center Climate System Model from CMIP5 to CMIP6 - Yinghan Sang; Hong-Li Ren; Xueli Shi; Xiaofeng Xu; Haishan Chen (Advances in Atmospheric Sciences, 2021)

PapA , a peptidoglycan‐associated protein, interacts with OmpC and maintains cell envelope integrity - Yun‐Hao Wang; Hong‐He Chen; Zhou Huang; Xiao‐Jing Li; Nan Zhou; Chang Liu; Cheng‐Ying Jiang; De‐Feng Li; Shuang‐Jiang Liu (Environmental Microbiology, 2021)
Summary The bacterial cell envelope is critical to support and maintain cellular life. In Gram‐negative bacterial cells, the outer membrane and the peptidoglycan layer are two important parts of the cell envelope and they harbour abundant proteins. Here, we report the identification and characterization of a previously unknown p eptidoglycan‐ a ssociated p rotein, PapA, from the Gram‐negative Comamonas testosteroni . PapA bound peptidoglycan with its C‐terminal domain and interacted with the outer‐membrane porin OmpC. The PapA‐OmpC complex riveted the outer membrane and the peptidoglycan layer, and played a role in maintaining cell envelope integrity. When papA was disrupted, the mutant CNB‐1Δ papA apparently had an outer membrane partly separated from the peptidoglycan layer. Phenotypically, the mutant CNB‐1Δ papA lost chemotactic responses and had longer lag‐phase of growth, less flagellation and higher sensitivity to harsh environments. Totally, 1093 functionally unknown PapA homologues were identified from the public NR protein database and they were mainly distributed in Burkholderiales of Betaproteobacteria. Our finding provides a clue that the PapA homologous proteins might function as a rivet to maintain cell envelope integrity in those Gram‐negative bacteria.

Sesquiterpenoids and meroterpenoids from a mangrove derived fungus Diaporthe sp. SCSIO 41011 - Xiao-Wei Luo; Chun-Mei Chen; Kun-Long Li; Xiu-Ping Lin; Cheng-Hai Gao; Xue-Feng Zhou; Yong-Hong Liu (Natural Product Research, 2021)

IbERF71, with IbMYB340 and IbbHLH2, coregulates anthocyanin accumulation by binding to the IbANS1 promoter in purple-fleshed sweet potato (Ipomoea batatas L.) - Zhiyuan Ning; Kangdi Hu; Zhilin Zhou; Donglan Zhao; Jun Tang; Hong Wang; Lixia Li; Chen Ding; Xiaoyan Chen; Gaifang Yao; Hua Zhang (Plant Cell Reports, 2021)

Effects of miR-125b-5p on Preadipocyte Proliferation and Differentiation in Chicken - Guoxi Li; Yi Chen; Wenjiao Jin; Bin Zhai; Yuanfang Li; Guirong Sun; Hong Li; Xiangtao Kang; Yadong Tian (Molecular Biology Reports, 2021)

Study on NOx removal from simulated flue gas by an electrobiofilm reactor: EDTA-ferrous regeneration and biological kinetics mechanism - Nan Liu; Ying-ying Li; Du-juan Ouyang; Rui Guo; Run Chen; Wei Li; Ji-xiang Li; Ji-hong Zhao (Environmental Science and Pollution Research, 2021)

The economic loss of public health from PM2.5 pollution in the Fenwei Plain - Ziyu Dong; Li Li; Yalin Lei; Sanmang Wu; Dan Yan; Hong Chen (Environmental Science and Pollution Research, 2021)

Willingness of rural residents to pay for clean coal and stoves in winter: an empirical study from Zoucheng, Shandong - Jiaqi Wang; Ruyin Long; Hong Chen; Qianwen Li (Environmental Science and Pollution Research, 2021)

A review on Cadmium Exposure in the Population and Intervention Strategies Against Cadmium Toxicity - Mei Wang; Zhaofang Chen; Wei Song; Dezi Hong; Lei Huang; Yunhui Li (Bulletin of Environmental Contamination and Toxicology, 2021)

Field tests of micro screw anchor piles under different loading conditions at three soil sites - Shi-Jin Feng; Wen-Ding Fu; Hong-Xin Chen; Hong-Xing Li; Yan-Li Xie; Shao-Feng Lv; Jin Li (Bulletin of Engineering Geology and the Environment, 2021)

Artificial Neural Network-based prediction of glacial debris flows in the ParlungZangbo Basin, southeastern Tibetan Plateau, China - Wang Tang; Hai-tao Ding; Ning-sheng Chen; Shang-Chang Ma; Li-hong Liu; Kang-lin Wu; Shu-feng Tian (Journal of Mountain Science, 2021)

Complete genome analysis of a novel iflavirus from a leaf beetle, Aulacophora lewisii - Zhuang-Xin Ye; Yue-Hong Li; Jian-Ping Chen; Chuan-Xi Zhang; Jun-Min Li (Archives of Virology, 2021)

Phylogenetic analysis of infectious bronchitis virus circulating in southern China in 2016–2017 and evaluation of an attenuated strain as a vaccine candidate - Libin Chen; Bin Xiang; Yanfen Hong; Qian Li; Haoyun Du; Qiuyan Lin; Ming Liao; Tao Ren; Chenggang Xu (Archives of Virology, 2021)

From China’s Heavy Precipitation in 2020 to a “Glocal” Hydrometeorological Solution for Flood Risk Prediction - Huan Wu; Xiaomeng Li; Guy J.-P. Schumann; Lorenzo Alfieri; Yun Chen; Hui Xu; Zhifang Wu; Hong Lu; Yamin Hu; Qiang Zhu; Zhijun Huang; Weitian Chen; et al. (Advances in Atmospheric Sciences, 2021)

Chemical constituents from the South China sea soft coral Sinularia humilis - Jie Li; Xia-Juan Huan; Meng-Jun Wu; Zi-Hui Chen; Bao Chen; Ze-Hong Miao; Yue-Wei Guo; Xu-Wen Li (Natural Product Research, 2020)

Classification of schizophrenia using general linear model and support vector machine via fNIRS - Lei Chen; Qiang Li; Hong Song; Ruiqi Gao; Jian Yang; Wentian Dong; Weimin Dang (Physical and Engineering Sciences in Medicine, 2020)

The extract of aquatic macrophyte Carex cinerascens induced colony formation in bloom-forming cyanobacterium Microcystis aeruginosa - Lin Li; Xiao-ling Jing; Ling Wang; Zhi-gao Zeng; Wen-hong Chen; Jia-hao Zhai; Si-qin Qi (Environmental Science and Pollution Research, 2020)

Cell wall surface layer (S-layer) promotes colony formation in Microcystis: comparison of S-layer characteristics between colonial and unicellular forms of Microcystis and function conformation - Yao Zu; Sujuan Hong; Chongxin Xu; Weiwei Li; Siyu Chen; Jianhong Li (Environmental Science and Pollution Research, 2020)

Induced sputum metabolomic profiles and oxidative stress are associated with chronic obstructive pulmonary disease (COPD) severity: potential use for predictive, preventive, and personalized medicine - Tao Zhu; Shanqun Li; Jiajia Wang; Chunfang Liu; Lei Gao; Yuzhen Zeng; Ruolin Mao; Bo Cui; Hong Ji; Zhihong Chen (EPMA Journal, 2020)
Chronic obstructive pulmonary disease (COPD) is a highly heterogeneous disease, and metabolomics plays a hub role in predictive, preventive, and personalized medicine (PPPM) related to COPD. This study thus aimed to reveal the role of induced sputum metabolomics in predicting COPD severity. In this pilot study, a total of 20 COPD patients were included. The induced sputum metabolites were assayed using a liquid chromatography-mass spectrometry (LC-MS/MS) system. Five oxidative stress products (myeloperoxidase (MPO), superoxide dismutase (SOD), glutathione (GSH), neutrophil elastase (NE), and 8-iso-PGF2α) in induced sputum were measured by ELISA, and the metabolomic profiles were distinguished by principal component analysis (PCA) and orthogonal projections to latent structures discriminant analysis (OPLS-DA). The Kyoto Encyclopedia of Genes and Genomes (KEGG) was used for pathway enrichment analysis, and a significant difference in induced sputum metabolomics was observed between moderate and severe COPD. The KEGG analysis revealed that the glycerophospholipid metabolism pathway was downregulated in severe COPD. Due to the critical role of glycerophospholipid metabolism in oxidative stress, significant negative correlations were discovered between glycerophospholipid metabolites and three oxidative stress products (SOD, MPO, and 8-iso-PGF2α). The diagnostic values of SOD, MPO, and 8-iso-PGF2α in induced sputum were found to exhibit high sensitivities and specificities in the prediction of COPD severity. Collectively, this study provides the first identification of the association between induced sputum metabolomic profiles and COPD severity, indicating the potential value of metabolomics in PPPM for COPD management. The study also reveals the correlation between glycerophospholipid metabolites and oxidative stress products and their value for predicting COPD severity.

Study on the Diversity and Function of Gut Microbiota in Pigs Following Long-Term Antibiotic and Antibiotic-Free Breeding - Yao Li; Yuhua Zhu; Hong Wei; Yaosheng Chen; Haitao Shang (Current Microbiology, 2020)

The Complete Genome Sequence of a Bacterial Strain with High Alkalic Xylanase Activity Isolated from the Sludge Near a Papermill - Si Chen; Hao Feng; Xin Li; Hong-jun Chao; Jing Wu; Jun Liu; Wen-jun Zhu; Da-zhong Yan (Current Microbiology, 2020)

Larger regional volume of the thalamus in diarrhea-predominant irritable bowel syndrome: a cross-sectional study - Cui Ping Mao; Fen Rong Chen; Hong Hong Sun; Mei Juan Shi; Hua Juan Yang; Xiao Hui Li; Dun Ding (Brain Imaging and Behavior, 2020)

Voxel-based morphometry results in first-episode schizophrenia: a comparison of publicly available software packages - Chen Li; Wenming Liu; Fan Guo; Xingrui Wang; Xiaowei Kang; Yongqiang Xu; Yibin Xi; Huaning Wang; Yuanqiang Zhu; Hong Yin (Brain Imaging and Behavior, 2020)

Characterization and genome analysis of Klebsiella phage P509, with lytic activity against clinical carbapenem-resistant Klebsiella pneumoniae of the KL64 capsular type - Min Li; Yuyi Xiao; Pei Li; Zitong Wang; Weiling Qi; Zitai Qi; Liang Chen; Hong Du; Wei Zhang (Archives of Virology, 2020)

Dietary lipid concentrations influence growth, body composition, morphology of the liver and mid-intestine, and antioxidant status of marbled eel (Anguilla marmorata) - Shi-Jun Chen; Peng Liu; You-Ming Jia; Hong-Ping Liao; Shao-Xuan Zhu; Li-Liu Zhou; Xue-Ming Dan; Li Liu; Jia-Hao Li; Su-Bi Zheng; Jun-Jiang Yang; Lian Gan (Aquaculture International, 2020)

Influence of complex topography on magnetotelluric-observed data using three-dimensional numerical simulation: A case from Guangxi area, China - Xiong Bin; Luo Tian-Ya; Chen Long-Wei; Dai Shi-Kun; Xu Zhi-Feng; Li Chang-Wei; Ding Yan-Li; Wang Hong-Hua; Li Jing-He (Applied Geophysics, 2020)

Examining the cooperative governance of occupational safety and health from a “health footprint” perspective - Shanshan Li; Hong Chen; Feiyu Chen; Xin Gan; Menghua Yang (Natural Hazards, 2020)

Characterization of a Protease Hyper-Productive Mutant of Bacillus pumilus by Comparative Genomic and Transcriptomic Analysis - Yong-Cheng Liu; Lin-Li Han; Tian-Yu Chen; Yan-Bing Lu; Hong Feng (Current Microbiology, 2020)

Inhibition of nattokinase against the production of poly (γ-glutamic Acid) in Bacillus subtilis natto - Li Wang; Ning Liu; Chenrui Yu; Junliu Chen; Kangjin Hong; Yipeng Zang; Mengmeng Wang; Guangjun Nie (Biotechnology Letters, 2020)

Low Serum Uric Acid Levels Promote Hypertensive Intracerebral Hemorrhage by Disrupting the Smooth Muscle Cell-Elastin Contractile Unit and Upregulating the Erk1/2-MMP Axis - Ning Xiao; Tian-long Liu; Hao Li; Hao-chen Xu; Jing Ge; Hong-yan Wen; Cong-xia Bai; Li Song; Ying-ying Sun; Yin-hui Zhang; Ru-tai Hui; Wei-hua Song; et al. (Translational Stroke Research, 2020)

Co-expression network analysis uncovers key candidate genes related to the regulation of volatile esters accumulation in Woodland strawberry - Zekun Li; Zhennan Wang; Kejing Wang; Yue Liu; Yanhong Hong; Changmei Chen; Xiayu Guan; Qingxi Chen (Planta, 2020)

Genetic diversity comparisons of wild populations of Nelumbo nucifera (Nelumbonaceae) in Russia and China using microsatellite markers - Zhi-Zhong Li; Md. Rabiul Islam; Shi-Xu Huang; Dan Yang; Yeshitila Mekbib; Popova Svetlana; Hong-Bing Sun; Jin-Ming Chen; Xing-Yu Yang (Plant Systematics and Evolution, 2020)

Soil temperature drives elevational patterns of reproductive allometry in a biodiversity hotspot - Kai Chen; Qing Liu; Zi-Hong Chen; Zu-Lei Li (Plant Ecology, 2020)

Application of Rough Set Method Based on Modified Efficiency Coefficient in Slope Stability Analysis - Chen Qiao; Chang-hong Li; Yong-gang Xiao (Geotechnical and Geological Engineering, 2020)

Impaired functional connectivity of limbic system in migraine without aura - Heng-Le Wei; Jinan Chen; Yu-Chen Chen; Yu-Sheng Yu; Gang-Ping Zhou; Li-Jie Qu; Xindao Yin; Junrong Li; Hong Zhang (Brain Imaging and Behavior, 2020)

The neural mechanisms of immediate and follow-up of the treatment effect of hypnosis on smoking craving - Xiaoming Li; Lijun Chen; Ru Ma; Haibao Wang; Li Wan; Junjie Bu; Wei Hong; Wanwan Lv; Yihong Yang; Hengyi Rao; Xiaochu Zhang (Brain Imaging and Behavior, 2020)

Characteristics of the spike and ORF3 genes of porcine epidemic diarrhea virus in Henan and Shanxi provinces of China - Jian-tao Cui; Han Qiao; Cheng-yao Hou; Hui-Hua Zheng; Xin-Sheng Li; Lan-lan Zheng; Hong-Ying Chen (Archives of Virology, 2020)

Molecular epidemiology of enteroviruses associated with severe hand, foot and mouth disease in Shenzhen, China, 2014-2018 - Long Chen; Shao-Jian Xu; Xiang-Jie Yao; Hong Yang; Hai-Long Zhang; Jun Meng; Han-Ri Zeng; Xu-He Huang; Ren-Li Zhang; Ya-Qing He (Archives of Virology, 2020)

Noise does not equal bias in assessing the evolutionary history of the angiosperm flora of China: A response to Qian (2019) - Li‐Min Lu; Hai‐Hua Hu; Dan‐Xiao Peng; Bing Liu; Jian‐Fei Ye; Tuo Yang; Hong‐Lei Li; Miao Sun; Stephen A. Smith; Pamela S. Soltis; Douglas E. Soltis; Zhi‐Duan Chen (Journal of Biogeography, 2020)
In response to our paper on the evolutionary history of the Chinese flora, Qian suggests that certain features of the divergence time estimation employed might have led to biased conclusions in Lu et al (2018). Here, we consider Qian's specific criticisms, explore the extent of uncertainty in the data and demonstrate that (i) no systematic bias toward dates that are too young or too old is detected in Lu et al.; (ii) constraint of the crown age of angiosperms does not bias the generic ages estimated by Lu et al.; and (iii) ages derived from the Chinese regional phylogeny do not bias the conclusions reported by Lu et al. All these analyses confirm that the conclusions reported previously are robust. We argue that, like many large‐scale biodiversity analyses, sources of noise in divergence time estimation are to be expected, but these should not be confused with bias.

Cytotoxic triquinane-type sesquiterpenoids from the endophytic fungus Cerrena sp. A593 - Hong-Xin Liu; Hai-Bo Tan; Yu-Chan Chen; Sai-Ni Li; Hao-Hua Li; Wei-Min Zhang (Natural Product Research, 2020)

MYH7B variants cause hypertrophic cardiomyopathy by activating the CaMK-signaling pathway - Peng Chen; Zongzhe Li; Jiali Nie; Hong Wang; Bo Yu; Zheng Wen; Yang Sun; Xiaolu Shi; Li Jin; Dao-Wen Wang (Science China Life Sciences, 2020)

Early use of dexamethasone increases Nr4a1 in Kupffer cells ameliorating acute liver failure in mice in a glucocorticoid receptor-dependent manner - Jing-wen Deng; Qin Yang; Xiao-peng Cai; Jia-ming Zhou; Wei-gao E; Yan-dong An; Qiu-xian Zheng; Meng Hong; Yan-li Ren; Jun Guan; Gang Wang; Shu-jing Lai; et al. (Journal of Zhejiang University-SCIENCE B, 2020)

Retraction Note to: Ambient air pollution and adverse birth outcomes: a systematic review and meta-analysis - Le-qian Guo; Yu Chen; Bai-bing Mi; Shao-nong Dang; Dou-dou Zhao; Rong Liu; Hong-li Wang; Hong Yan (Journal of Zhejiang University-SCIENCE B, 2020)

Direct and indirect plant defenses induced by (Z)-3-hexenol in tomato against whitefly attack - Fengbo Yang; Qinghe Zhang; Qixi Yao; Gong Chen; Hong Tong; Jianmin Zhang; Chuanren Li; Qi Su; Youjun Zhang (Journal of Pest Science, 2020)

Heat-air-moisture coupled model for radon migration in a porous media - Yu Cui; Shengyang Feng; Puxin Chen; Yongjun Ye; Yurong Wu; Ce Li; Rong Yang; Hong Wang (Environmental Science and Pollution Research, 2020)

Estimating purple-soil moisture content using Vis-NIR spectroscopy - Yu Gou; Jie Wei; Jin-lin Li; Chen Han; Qing-yan Tu; Chun-hong Liu (Journal of Mountain Science, 2020)

Ghrelin Reduces A-Type Potassium Currents in Dopaminergic Nigral Neurons via the PLC/PKCδ Pathway - Bao Xue; Chen Li; Xiaoli Chang; Hong Jiang; Limin Shi; Junxia Xie (Neuroscience Bulletin, 2020)

Microencapsulation of immunoglobulin Y: optimization with response surface morphology and controlled release during simulated gastrointestinal digestion - Jin Zhang; Huan-huan Li; Yi-fan Chen; Li-hong Chen; Hong-gang Tang; Fan-bin Kong; Yun-xin Yao; Xu-ming Liu; Qian Lan; Xiao-fan Yu (Journal of Zhejiang University-SCIENCE B, 2020)

TMEM88 modulates the secretion of inflammatory factors by regulating YAP signaling pathway in alcoholic liver disease - Liang-yun Li; Chen-chen Yang; Su-wen Li; Yu-min Liu; Hao-dong Li; Shuang Hu; Hong Zhou; Jin-liang Wang; Hang Shen; Xiao-ming Meng; Jun Li; Tao Xu (Inflammation Research, 2020)

Privet golden leaves adapt unexpectedly well to light changes - Ming Yuan; Bo Huang; Li-Hua Dong; Qiao-Hong Han; Yong Yang; Chun-Bang Ding; Chao Hu; Yang-Er Chen; Zhong-Wei Zhang; Shu Yuan (Horticulture, Environment, and Biotechnology, 2020)

Brief report of the first cured 2019-nCoV pneumonia patient in West China Hospital - En-Qiang Chen; Li-Chun Wang; Guang-Min Tang; Yao Yang; Min-Jin Wang; Rong Deng; Fang Chen; Meng-Lan Wang; Ya-Chao Tao; Ping Feng; Hong Tang (European Journal of Clinical Microbiology & Infectious Diseases, 2020)

Assessing drug cue-induced brain response in heroin dependents treated by methadone maintenance and protracted abstinence measures - Xuan Wei; Wei Li; Jiajie Chen; Yongbin Li; Jia Zhu; Hong Shi; Jierong Liu; Jiuhua Xue; Wei Liu; Fan Wang; Yan Liu; Shan Dang; et al. (Brain Imaging and Behavior, 2020)

New Terpenoids And Lignans From The Twigs Of T ripterygium Hypoglaucum - Hui Zheng; Li Wang; Tao Yang; Dan Liu; Hong-Mei Li; Xuan-Qin Chen; Rong-Tao Li (Natural Product Research, 2020)

A review of progress in coupled ocean-atmosphere model developments for ENSO studies in China - Rong-Hua Zhang; Yongqiang Yu; Zhenya Song; Hong-Li Ren; Youmin Tang; Fangli Qiao; Tongwen Wu; Chuan Gao; Junya Hu; Feng Tian; Yuchao Zhu; Lin Chen; et al. (Journal of Oceanology and Limnology, 2020)

MESP2 variants contribute to conotruncal heart defects by inhibiting cardiac neural crest cell proliferation - Erge Zhang; Jianping Yang; Yang Liu; Nanchao Hong; Huilin Xie; Qihua Fu; Fen Li; Sun Chen; Yu Yu; Kun Sun (Journal of Molecular Medicine, 2020)

Long noncoding RNA LINC00520 accelerates the progression of colorectal cancer by serving as a competing endogenous RNA of microRNA-577 to increase HSP27 expression - Xi-Han Jin; Yong-Gang Hong; Peng Li; Li-Qiang Hao; Ming Chen (Human Cell, 2020)

Effects of nitrogen source and N/P on growth and photosynthesis in the invasive marine macroalga Chaetomorpha valida - Chen Li-hong; Xing Rong-lian; Jiang Ai-li; Yao Ya-nan; Zhou Ge-fei (Environmental Science and Pollution Research, 2020)

Distinct Characteristics of Bacterial Community in the Soil of Nanshazhou Island, South China Sea - Yong-gan Chen; Zhen-hua Zhang; Hong-wei Luo; Zhen Li; Lai-jun Zhang; Hai Huang (Current Microbiology, 2020)

Comparative transcriptomic analysis of fireflies (Coleoptera: Lampyridae) to explore the molecular adaptations to fresh water - Qi‐Lin Zhang; Hong‐Wei Li; Zhi‐Xiang Dong; Xiao‐Jie Yang; Lian‐Bing Lin; Jun‐Yuan Chen; Ming‐Long Yuan (Molecular Ecology, 2020)
Aquatic insects are well adapted to freshwater environments, but the molecular basis of these adaptations remains largely unknown. Most firefly species (Coleoptera: Lampyridae) are terrestrial, but the larvae of several species are aquatic. Here, larval and adult transcriptomes from Aquatica leii (freshwater) and Lychnuris praetexta (terrestrial) were generated to test whether the genes associated with metabolic efficiency and morphology have undergone adaptive evolution to fresh water. The aquatic fireflies had a significantly lower ratio of nonsynonymous to synonymous substitutions than the terrestrial insects, indicating a genomewide evolutionary constraint in the aquatic fireflies. We identified 341 fast‐evolving genes and 116 positively selected genes in the aquatic fireflies. Of these, 76 genes exhibiting both fast evolution and positive selection were primarily involved in ATP production, energy metabolism and the hypoxia response. We identified 7,271 differentially expressed genes (DEGs) in A . leii (adults versus larvae) and 8,309 DEGs in L . praetexta (adults versus larvae). DEGs specific to the aquatic firefly ( n = 1,445) were screened via interspecific comparisons ( A . leii versus L . praetexta ) and were significantly enriched for genes involved in metabolic efficiency (e.g., ATP production, hypoxia, and immune responses) and certain aspects of morphology (e.g., cuticle chitin, tracheal and compound eye morphology). These results indicate that sequence and expression‐level changes in genes associated with both metabolic efficiency and morphological attributes related to the freshwater lifestyle contributed to freshwater adaptation in fireflies. This study provides new insights into the molecular mechanisms of aquatic adaptation in insects.

New 2-(2-phenylethyl)chromone derivatives from agarwood and their inhibitory effects on tumor cells - Yang-Yang Liu; De-Li Chen; Zhang-Xin Yu; Wang Can-Hong; Jian Feng; Yu Meng; Jian-He Wei (Natural Product Research, 2020)

Scutellarin Exerts Anti-Inflammatory Effects in Activated Microglia/Brain Macrophage in Cerebral Ischemia and in Activated BV-2 Microglia Through Regulation of MAPKs Signaling Pathway - Hao-Lun Chen; Wen-Ji Jia; Hong-E Li; Hong Han; Fan Li; Xiao-Li-Na Zhang; Juan-Juan Li; Yun Yuan; Chun-Yun Wu (NeuroMolecular Medicine, 2020)

Cognitive Load of Exercise Influences Cognition and Neuroplasticity of Healthy Elderly: An Exploratory Investigation - Yi-Ping Chao; Changwei W. Wu; Li-Jung Lin; Cheng-Hung Lai; Hong-Yi Wu; Ai-Ling Hsu; Chiao-Nan Chen (Journal of Medical and Biological Engineering, 2020)
This study explored the effects of exercise with either high cognitive load or low cognitive load on cognitive performance and neuroplasticity in healthy elderly. Twenty-eight sedentary community-dwelling seniors participated in this study. Participants were assigned to one of three groups: the control group (C), low-cognitive load exercise group (LE), or high-cognitive load exercise group (HE). Individuals in both exercise groups engaged in moderate-intensity aerobic exercise for 4 months. Resting-state functional MRI and diffusion MRI were used to investigate the effects of intervention on functional and structural connectivity, respectively. Analysis of covariance with baseline, age and the education year as covariates was used to determine the effects of intervention. We found 4 months of exercise with high-cognitive load, but not exercise with low-cognitive load, improved the overall cognitive function of healthy elderly. Additionally, the HE group showed increased resting-state functional connectivity of superior frontal gyrus and anterior cingulate cortex and decreased functional connectivity of middle occipital gyrus and postcentral gyrus. The age-related alterations in local efficiency and betweenness were protected by exercise. Our findings might suggest that exercise with greater cognitive load likely results in greater training effects on cognition and brain connectivity than exercise requiring lower cognitive loads for healthy elderly.

Correction to: Simulated microgravity significantly altered metabolism in epidermal stem cells - Bin-Bin Li; Zheng-Yang Chen; Nan Jiang; Song Guo; Jia-Qi Yang; Shao-Bin Chai; Hong-Feng Yan; Pei-Ming Sun; Gang Hu; Tao Zhang; Bing-Xin Xu; Hong-Wei Sun; et al. (In Vitro Cellular & Developmental Biology - Animal, 2020)

Study on Transient Unloading Response Characteristics of Brittle Coal Samples Under Different Stress Paths - Chen Qiao; Chang-hong Li; Guang-nan Ma (Geotechnical and Geological Engineering, 2020)

Short-term associations between ambient fine particulate matter pollution and hospital visits for chronic obstructive pulmonary disease in Yinzhou District, China - Cheng-yi Lin; Die Li; Jie-ming Lu; Zhe-bin Yu; Yao Zhu; Peng Shen; Meng-ling Tang; Ming-juan Jin; Hong-bo Lin; Li-ming Shui; Kun Chen; Jian-bing Wang (Environmental Science and Pollution Research, 2020)

Functional connectivity dysfunction of insular subdivisions in cognitive impairment after acute mild traumatic brain injury - Liyan Lu; Fengfang Li; Huiyou Chen; Peng Wang; Hong Zhang; Yu-Chen Chen; Xindao Yin (Brain Imaging and Behavior, 2020)
Purpose This study aimed to investigate the early functional connectivity alterations between insula subdivisions and other cortical regions in patients with acute mild traumatic brain injury (mTBI) and subsequently to explore the relationship between functional connectivity changes of insula subdivisions with other cortical regions and cognitive function. Methods Fifty-three mTBI patients and 37 age-, gender- and education level- matched healthy controls were included in this study. All participants obtained resting state functional magnetic resonance imaging (rs-fMRI) and clinical and neuropsychological evaluations (Montreal cognitive assessment, MoCA) at the acute stage. Functional connectivity alterations of insula subdivisions and correlations with MoCA were further explored by seed-voxel functional connectivity. Results Compared with healthy controls, patients with acute mTBI showed significantly decreased functional connectivity between the L-vAI and the left middle temporal gyrus and right superior frontal gyrus and significantly decreased functional connectivity between the R-vAI and the right middle frontal gyrus and right hippocampus. While significantly decreased functional connectivity were observed between the L-dAI and the right superior frontal gyrus. In addition, significantly increased functional connectivity was observed between the R-PI and the left inferior frontal gyrus. Furthermore, the mTBI group demonstrated positive correlations between performances in orientation and insula and middle temporal gyrus and superior frontal gyrus and middle frontal gyrus functional connectivities. Abstraction scores for mTBI patients positively correlated with functional connectivity between insula and middle frontal gyrus. Conclusions The present study demonstrated functional connectivity dysfunction of insula subdivisions and correlations between these alterations and cognitive performance, which provide a novel insight into the neurophysiological mechanism of cognitive impairment in patients with mTBI at the acute stage.

Neuroanatomical and functional alterations of insula in mild traumatic brain injury patients at the acute stage - Fengfang Li; Liyan Lu; Huiyou Chen; Peng Wang; Hong Zhang; Yu-Chen Chen; Xindao Yin (Brain Imaging and Behavior, 2020)

Molecular evolution of GII.P17-GII.17 norovirus associated with sporadic acute gastroenteritis cases during 2013–2018 in Zhoushan Islands, China - Can Chen; Bing Wu; Hui Zhang; Ke-Feng Li; Rong Liu; Hong-Ling Wang; Jian-Bo Yan (Virus Genes, 2020)

Trace elements determination and health risk assessment of Tricholoma matsutake from Yunnan Province, China - Hong-xian Chen; Yun Chen; Songfei Li; Wei Zhang; Ying Zhang; Shan Gao; Na Li; Lei Tao; Ying Wang (Journal of Consumer Protection and Food Safety, 2020)

Microsatellite records for volume 12, issue 2 - In-Chul Bang; Fleur Bruggemann; Chen Chen; Quentin D’Alexis; Hongmei Gao; Pauline Gélin; Xiaoyou Hong; Miho Inoue-Murayama; Kang-Rae Kim; Yeong-Ho Kwak; Wei Li; Haitao Ma; et al. (Conservation Genetics Resources, 2020)

Numerical simulation study on the evolution law of mine pressure in deep mining - Chen Qiao; Chang-hong Li; Xiao-ming Wei; Yong-yue Hu (Arabian Journal of Geosciences, 2020)

Identification and characterization of two morphologically distinct stem cell subpopulations from human urine samples - An-Jing Chen; Jin-Kui Pi; Jun-Gen Hu; Yi-Zhou Huang; Hong-Wei Gao; Sheng-Fu Li; Jesse Li-Ling; Hui-Qi Xie (Science China Life Sciences, 2020)

Synthesis and biological effects of naphthalene-chalcone derivatives - Qing-Hao Jin; Hong-Hai Chen; Wen-Bo Chen; Zhi-Yang Fu; Li-Ping Guan; Hai-Ying Jiang (Medicinal Chemistry Research, 2020)

Conversion between porcine naïve-like and primed ESCs and specific pluripotency marker identification - Qiaoyu Chen; Hong Zhang; Haibin Jiang; Manling Zhang; Junzheng Wang; Lihua Zhao; Chenyu Wang; Manling Liu; Rongfeng Li (In Vitro Cellular & Developmental Biology - Animal, 2020)

Hippocampus-specific regulation of long non-coding RNA and mRNA expression in germ-free mice - Chanjuan Zhou; Xuechen Rao; Haiyang Wang; Benhua Zeng; Yue Yu; Jianjun Chen; Jiaju Zhong; Xunzhong Qi; Li Zeng; Peng Zheng; Wei Hong; Peng Xie (Functional & Integrative Genomics, 2020)

Effects of Elevated Ozone Concentrations on Root Characteristics and Soil Properties of Elaeocarpus sylvestris and Michelia chapensis - Lan Pan; Wan-qi Lin; Ming Yu; Gan-wen Lie; Li Xue; Hong-yue Chen (Bulletin of Environmental Contamination and Toxicology, 2020)

Establishment and characterization of an immortalized human chondrocyte cell line - Jiashu Yang; Yuting Tang; Wensun Chen; Ming Zhang; Fangling Hong; Dawei Yang; Qianyi Bao; Ying Yang; Yucui Jin; Lingyun Li; Changyan Ma (Biotechnology Letters, 2020)

A new triterpenoid saponin from Pulsatilla cernua predicted by NMR-based mosaic method - An-Dong Wang; Ying Bao; Xia Wang; Mei-Chen Li; Xu-Hong Ren; Jian-Yu Liu; Yong-Nan Xu (Natural Product Research, 2020)

Serum Uric Acid Levels and Risk of Intracranial Atherosclerotic Stenosis: A Cross-Sectional Study - Lin Li; Jun-Xia Zhu; Xiao-He Hou; Ya-Hui Ma; Wei Xu; Chen-Chen Tan; Fu-Rong Sun; Hong-Qi Li; Qiang Dong; Lan Tan; Jin-Tai Yu (Neurotoxicity Research, 2020)

The Potential Role of PKA/CREB Signaling Pathway Concerned with Gastrodin Administration on Methamphetamine-Induced Conditioned Place Preference Rats and SH-SY5Y Cell Line - Gen-Meng Yang; Lu Li; Feng-Lin Xue; Chen-Li Ma; Xiao-Feng Zeng; Yong-Na Zhao; Dong-Xian Zhang; Yang Yu; Qian-Wen Yan; Yi-Qing Zhou; Shi-Jun Hong; Li-Hua Li (Neurotoxicity Research, 2020)

Synchrotron Radiation-Based Three-Dimensional Visualization of Angioarchitectural Remodeling in Hippocampus of Epileptic Rats - Pan Gu; Zi-Hao Xu; Yu-Ze Cao; Sheng-Hui Liao; Qian-Fang Deng; Xian-Zhen Yin; Zhuo-Lu Wang; Zhuo-Hui Chen; Xin-Hang Hu; Hui Wang; Li-Zhi Li; Shi-Xin Liu; et al. (Neuroscience Bulletin, 2020)

Development of 19 novel microsatellite markers of lily-of-the-valley (Convallaria, Asparagaceae) from transcriptome sequencing - Qi-Xiang Lu; Jing Gao; Jun-Jie Wu; Xuan Zhou; Xue Wu; Meng-Di Li; Yu-Kun Wei; Rui-Hong Wang; Zhe-Chen Qi; Pan Li (Molecular Biology Reports, 2020)

The acute effects of ultraviolet radiation exposure on solar dermatitis in Shanghai, China - Guojiang Zhou; Li Peng; Wei Gao; Ying Zou; Yimei Tan; Yangfeng Ding; Shanqun Li; Hong Sun; Renjie Chen (International Journal of Biometeorology, 2020)

Statistical optimization of a cellulase from Aspergillus glaucus CCHA for hydrolyzing corn and rice straw by RSM to enhance yield of reducing sugar - Lina Chen; Yi Wei; Mao Shi; Zhengqun Li; Shi-Hong Zhang (Biotechnology Letters, 2020)

Coix seed oil prolongs lifespan and enhances stress resistance in Caenorhabditis elegans - Xin-Yan Chen; De-Chun Liao; Ying-Ting Yu; Cong-Min Wei; Ling-Yan Xuan; Shan Li; Hong-Bing Wang (Biogerontology, 2020)

The inhibition of miR-17-5p promotes cortical neuron neurite growth via STAT3/GAP-43 pathway - Liang Zhang; Zhijie Wang; Bo Li; Ziwei Xia; Xin Wang; Yucai Xiu; Zheng Zhang; Chuanjie Chen; Hong Song; Wenhua Li; Mei Yu; Meiling Zhang; et al. (Molecular Biology Reports, 2020)

Simulated microgravity significantly altered metabolism in epidermal stem cells - Bin-Bin Li; Zheng-Yang Chen; Nan Jiang; Song Guo; Jia-Qi Yang; Shao-Bin Chai; Hong-Feng Yan; Pei-Ming Sun; Gang Hu; Tao Zhang; Bing-Xin Xu; Hong-Wei Sun; et al. (In Vitro Cellular & Developmental Biology - Animal, 2020)
Simulated microgravity can significantly affect various cell types and multiple systems of the human body, such as cardiovascular system, skeletal muscle system, and immune system, and is known to cause anemia and loss of electrolyte and fluids. Epidermal stem cells (EpSCs) were cultured in a rotary cell culture system (RCCS) bioreactor to simulate microgravity. The metabolites of EpSCs were identified by liquid chromatography-mass spectrometry (LC-MS). Compared with normal gravity (NG) group, a total of 57 different metabolites of EpSCs were identified ( P < 0.05, VIP > 1), including lipids and lipid-like molecules (51 molecules), amino acids (5 molecules), nucleosides, nucleotides, and analogues (1 molecule). According to the partial least squares discriminant analysis (PLS-DA) score plot, a VIP > 1 and P < 0.05 were obtained for the 57 different metabolites, of which 23 molecules were significantly downregulated and 34 were significantly upregulated in simulated microgravity (SMG) group. These results showed that SMG has a significant impact on different pathways, and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis indicated that multiple pathways were involved, mainly the amino acid metabolism pathway, lipid metabolism pathway, membrane transport pathway, and cell growth and death pathways. Thus, the metabolic profile of EpSCs was changed under SMG. Exploring the metabolic profile of EpSCs would be helpful to further understand the growth characteristics of EpSCs under SMG, which will provide a new approach to explore the metabolomics mechanism of stress injury and repair trauma under SMG.

Top-down attention modulates the direction and magnitude of sensory dominance - Ying Fang; You Li; Xiaoting Xu; Hong Tao; Qi Chen (Experimental Brain Research, 2020)

Comparative study on the bioaccumulation of lead, cadmium and nickel and their toxic effects on the growth and enzyme defence strategies of a heavy metal accumulator, Hydrilla verticillata (L.f.) Royle - Hong Zhang; Ling-Lei Zhang; Jia Li; Min Chen; Rui-Dong An (Environmental Science and Pollution Research, 2020)

Chemical Stimulation of Renal Tissue Induces Sympathetic Activation and a Pressor Response via the Paraventricular Nucleus in Rats - Chao Ye; Yun Qiu; Feng Zhang; Ai-Dong Chen; Hong Zhou; Jue-Jin Wang; Qi Chen; Yue-Hua Li; Yu-Ming Kang; Guo-Qing Zhu (Neuroscience Bulletin, 2020)

Effectiveness analysis of the prediction of regional debris flow susceptibility in post-earthquake and drought site - Ning-sheng Chen; Yong Zhang; Shu-feng Tian; Ming-feng Deng; Tao Wang; Li-hong Liu; Mei Liu; Gui-sheng Hu (Journal of Mountain Science, 2020)

Topographic controls on the annual runoff coefficient and implications for landscape evolution across semiarid Qilian Mountains, NE Tibetan Plateau - Shun Cai; Hao-peng Geng; Bao-tian Pan; Yang Hong; Li-ping Chen (Journal of Mountain Science, 2020)

The false smut pathogen Ustilaginoidea virens requires rice stamens for false smut ball formation - Jing Fan; Jie Liu; Zhi‐You Gong; Pei‐Zhou Xu; Xiao‐Hong Hu; Jin‐Long Wu; Guo‐Bang Li; Juan Yang; Yu‐Qiu Wang; Yu‐Feng Zhou; Shuang‐Cheng Li; Li Wang; et al. (Environmental Microbiology, 2020)
Summary Rice false smut has emerged as a serious grain disease in rice production worldwide. The disease is characterized by the transformation of individual rice florets into false smut balls, which is caused by the fungal pathogen Ustilaginoidea virens . To date, little is known about the host factors required for false smut ball formation by U . virens . In this study, we identified histological determinants for the formation of false smut balls by inoculating U . virens into rice floral mutants defective with respect to individual floral parts. The results showed that U . virens could form mature false smut balls in rice floral mutants with defective pistils, but failed to develop false smut balls in the superwoman mutant lacking stamens, identifying that U . virens requires rice stamens to complete its infection cycle. Comparative transcriptome analysis indicated a list of candidate host genes that may facilitate nutrient acquisition by U . virens from the rice stamens, such as SWEET11 , SWEET14 and SUT5 , and genes involved in the biosynthesis of trehalose and raffinose family sugars. These data pinpoint rice stamens as the key target organ of U . virens infection and provide a valuable starting point for dissecting the molecular mechanism of false smut ball formation.

Photoproduction of nitric oxide in seawater - Ye Tian; Gui-Peng Yang; Chun-Ying Liu; Pei-Feng Li; Hong-Tao Chen; Hermann W. Bange (Ocean Science, 2020)
Nitric oxide (NO) is a short-lived intermediate of the oceanic nitrogen cycle. However, our knowledge about its production and consumption pathways in oceanic environments is rudimentary. In order to decipher the major factors affecting NO photochemical production, we irradiated several artificial seawater samples as well as 31 natural surface seawater samples in laboratory experiments. The seawater samples were collected during a cruise to the western tropical North Pacific Ocean (WTNP, a N–S section from 36 to 2∘ N along 146 to 143∘ E with 6 and 12 stations, respectively, and a W–E section from 137 to 161∘ E along the Equator with 13 stations) from November 2015 to January 2016. NO photoproduction rates from dissolved nitrite in artificial seawater showed increasing trends with decreasing pH, increasing temperature, and increasing salinity. In contrast, NO photoproduction rates (average: 0.5±0.2×10-12 mol L−1 s−1) in the natural seawater samples from the WTNP did not show any correlations with pH, water temperature, salinity, or dissolved inorganic nitrite concentrations. The flux induced by NO photoproduction in the WTNP (average: 13×10-12 mol m−2 s−1) was significantly larger than the NO air–sea flux density (average: 1.8×10-12 mol m−2 s−1), indicating a further NO loss process in the surface layer.

Silicon isotope composition of subduction zone fluids as recorded by jadeitites from Myanmar - An-Xia Chen; Yuan-Hong Li; Yi Chen; Hui-Min Yu; Fang Huang (Contributions to Mineralogy and Petrology, 2020)

Wave and current-induced dynamic response in a multilayered poroelastic seabed - Hui-Feng Qi; Zhang-Long Chen; Yi-Cheng Li; Shi-Jin Feng; Hong-Xin Chen (Bulletin of Engineering Geology and the Environment, 2020)

Whole-genome DNA methylation patterns and complex associations with gene expression associated with anthocyanin biosynthesis in apple fruit skin - Wen-Fang Li; Gai-Xing Ning; Juan Mao; Zhi-Gang Guo; Qi Zhou; Bai-Hong Chen (Planta, 2019)

Energy transition, CO2 mitigation, and air pollutant emission reduction: scenario analysis from IPAC model - Kejun Jiang; Sha Chen; Chenmin He; Jia Liu; Sun Kuo; Li Hong; Songli Zhu; Xiang Pianpian (Natural Hazards, 2019)

Comparative transcriptome analysis of male and female gonads reveals sex-biased genes in spotted scat (Scatophagus argus) - Fei-Xiang He; Dong-Neng Jiang; Yuan-Qing Huang; Umar Farouk Mustapha; Wei Yang; Xue-Fan Cui; Chang-Xu Tian; Hua-Pu Chen; Hong-Juan Shi; Si-Ping Deng; Guang-Li Li; Chun-Hua Zhu (Fish Physiology and Biochemistry, 2019)

Concentration–response modeling of ECG data from early-phase clinical studies to assess QT prolongation risk of contezolid (MRX-I), an oxazolidinone antibacterial agent - Junzhen Wu; Kun Wang; Yuancheng Chen; Hong Yuan; Li Li; Jing Zhang (Journal of Pharmacokinetics and Pharmacodynamics, 2019)

Genome-based reclassification of Bacillus plakortidis Borchert et al. 2007 and Bacillus lehensis Ghosh et al. 2007 as a later heterotypic synonym of Bacillus oshimensis Yumoto et al. 2005; Bacillus rhizosphaerae Madhaiyan et al. 2011 as a later heterotypic synonym of Bacillus clausii Nielsen et al. 1995 - Guo-Hong Liu; Manik Prabhu Narsing Rao; Zhou-Yan Dong; Jie-Ping Wang; Jian-Mei Che; Qian-Qian Chen; Cetin Sengonca; Bo Liu; Wen-Jun Li (Antonie van Leeuwenhoek, 2019)