Holocene sea level trend on the west coast of Bohai Bay, China: reanalysis and standardization - Jianfen Li; Zhiwen Shang; Fu Wang; Yongsheng Chen; Lizhu Tian; Xingyu Jiang; Qian Yu; Hong Wang (Acta Oceanologica Sinica, 2021)

Genetic Architecture of Childhood Kidney and Urological Diseases in China - Ye Fang; Hua Shi; Tianchao Xiang; Jiaojiao Liu; Jialu Liu; Xiaoshan Tang; Xiaoyan Fang; Jing Chen; Yihui Zhai; Qian Shen; Guomin Li; Li Sun; et al. (Phenomics, 2021)
Kidney disease is manifested in a wide variety of phenotypes, many of which have an important hereditary component. To delineate the genotypic and phenotypic spectrum of pediatric nephropathy, a multicenter registration system is being implemented based on the Chinese Children Genetic Kidney Disease Database (CCGKDD). In this study, all the patients with kidney and urological diseases were recruited from 2014 to 2020. Genetic analysis was conducted using exome sequencing for families with multiple affected individuals with nephropathy or clinical suspicion of a genetic kidney disease owing to early-onset or extrarenal features. The genetic diagnosis was confirmed in 883 of 2256 (39.1%) patients from 23 provinces in China. Phenotypic profiles showed that the primary diagnosis included steroid-resistant nephrotic syndrome (SRNS, 23.5%), glomerulonephritis (GN, 32.2%), congenital anomalies of the kidney and urinary tract (CAKUT, 21.2%), cystic renal disease (3.9%), renal calcinosis/stone (3.6%), tubulopathy (9.7%), and chronic kidney disease of unknown etiology (CKDu, 5.8%). The pathogenic variants of 105 monogenetic disorders were identified. Ten distinct genomic disorders were identified as pathogenic copy number variants (CNVs) in 11 patients. The diagnostic yield differed by subgroups, and was highest in those with cystic renal disease (66.3%), followed by tubulopathy (58.4%), GN (57.7%), CKDu (43.5%), SRNS (29.2%), renal calcinosis /stone (29.3%) and CAKUT (8.6%). Reverse phenotyping permitted correct identification in 40 cases with clinical reassessment and unexpected genetic conditions. We present the results of the largest cohort of children with kidney disease in China where diagnostic exome sequencing was performed. Our data demonstrate the utility of family-based exome sequencing, and indicate that the combined analysis of genotype and phenotype based on the national patient registry is pivotal to the genetic diagnosis of kidney disease.

Mapping Domain- and Age-Specific Functional Brain Activity for Children’s Cognitive and Affective Development - Lei Hao; Lei Li; Menglu Chen; Jiahua Xu; Min Jiang; Yanpei Wang; Linhua Jiang; Xu Chen; Jiang Qiu; Shuping Tan; Jia-Hong Gao; Yong He; et al. (Neuroscience Bulletin, 2021)

DNA Methyltransferase 1 Is Dysregulated in Parkinson’s Disease via Mediation of miR-17 - Hong-Qiu Zhang; Jian-Yong Wang; Zhao-Feng Li; Lei Cui; Shi-Shi Huang; Lan-Bing Zhu; Yue Sun; Rui Yang; Hui-Hui Fan; Xiong Zhang; Jian-Hong Zhu (Molecular Neurobiology, 2021)

RNA-Seq Transcriptome Analysis of the Liver and Brain of the Black Carp (Mylopharyngodon piceus) During Fasting - Ya-Fan Dai; Yu-bang Shen; Shen-Tong Wang; Jia-Hua Zhang; Yu-Hong Su; Sheng-Chen Bao; Xiao-Yan Xu; Jia-Le Li (Marine Biotechnology, 2021)

Roles of bulk and rhizosphere denitrifying bacteria in denitrification from paddy soils under straw return condition - Ning Wang; Ya-Hui Zhao; Jian-Guang Yu; Li-Hong Xue; Hong-Bo Li; Lin-Zhang Yang (Journal of Soils and Sediments, 2021)

SR-B1 and CD10 combined immunoprofile for differential diagnosis of metastatic clear cell renal cell carcinoma and clear cell carcinoma of the ovary - Teng Jiang; Xiaoli Diao; Meili Ding; Xiao Niu; Chao Wang; Yan Qi; Wei Jia; Lijuan Pang; Wenhao Hu; Hong Zou; Feng Li (Journal of Molecular Histology, 2021)
Both clear cell renal carcinoma (ccRCC) and clear cell carcinoma of the ovary (CCOC) have a clear cytoplasmic morphological feature, hence it is difficult to identify metastatic ccRCC and CCOC by morphology alone. At present, there are no effective immunohistochemical markers to distinguish between these two tumors. Studies have shown that the clear cytoplasm of ccRCC is mainly caused by cholesterol-rich lipids in the cytoplasm, while that of CCOC is due to the accumulation of cytoplasmic glycogen. Objective: to hypothesize that the scavenger receptor class B-type 1 (SR-B1) protein responsible for HDL cholesterol uptake may be differentially expressed in ccRCC and CCOC, and high CD10 expression in the renal tubular epithelium may assist in distinguishing between ccRCC and CCOC. Methods: effective immunohistochemical markers were applied in 90 cases of renal clear cell carcinoma and 31 cases of ovarian cancer to distinguish between the two types of tumors.Result: SR-B1 and CD10 expression is significantly higher in ccRCC than CCOC. Both SR-B1 and CD10 exhibited focal weak-medium intensity staining in CCOC, and their staining extent and intensity were significantly lower than ccRCC. The sensitivity and specificity of SR-B1 for identifying ccRCC were 74.4% and 83.9%, respectively. The sensitivity and specificity of CD10 for identifying CCOC were 93.3% and 80.6%, respectively. The combined SR-B1( +) CD10( +) immunoprofile supports the diagnosis of ccRCC with a specificity of 93.5%. The combined SR-B1(-) CD10(-) immunoprofile supports the diagnosis of CCOC with a specificity of 93.3%. Conclusions: our findings demonstrate that the combination of SR-B1 and CD10 immunoprofiling is a valuable tool for differential diagnosis of ccRCC and CCOC.

The Knowledge and Attitude Towards Advance Care Planning Among Chinese Patients with Advanced Cancer - Xiao-Ting Hou; Yu-Han Lu; Hong Yang; Ren-Xiu Guo; Yun Wang; Li-Hong Wen; Ya-Ru Zhang; Hong-Yu Sun (Journal of Cancer Education, 2021)

Inhibition of the p38 MAPK pathway attenuates renal injury in pregnant rats with acute necrotizing pancreatitis - Jiacheng Zhang; Fangchao Mei; Liang Zhao; Teng Zuo; Yupu Hong; Man Li; Jia Yu; Weixing Wang (Immunologic Research, 2021)

Combining ability and genetic diversity under low-temperature conditions at germination stage of maize (Zea mays L.) - Jiayue Zhang; Yichen Li; Ziwen Zhang; Hong Di; Lin Zhang; Xuerui Wang; Zhenhua Wang; Yu Zhou (Euphytica, 2021)

Occurrence, distribution, and partitioning of antibiotics in surface water and sediment in a typical tributary of Yellow River, China - Linfang Wang; Hua Li; Jinhua Dang; Hong Guo; Yu’en Zhu; Wenhui Han (Environmental Science and Pollution Research, 2021)

Continuous production of fructooligosaccharides by recycling of the thermal-stable β-fructofuranosidase produced by Aspergillus niger - Juan Wang; Jing Zhang; Lu Wang; Hong Liu; Ning Li; Huanxia Zhou; Zhanguo Ning; Weican Zhang; Lushan Wang; Feng Huang; Yaohua Zhong (Biotechnology Letters, 2021)

The GIS study on the spatial structure and visual perception of historical districts in winter cities - Li Hong; Songling Pang; Meiyun Geng; Sihan Wang (Arabian Journal of Geosciences, 2021)

Ground roll separation method via threshold filtering and constraint of seismic wavelet support in curvelet domain - De-ying Wang; Li-hua Chen; Lie-qian Dong; Li-hong Zhao; Ren-wei Ding; Cheng-zhen Ding (Applied Geophysics, 2021)

Emergence and prevalence of naturally occurring lower virulent African swine fever viruses in domestic pigs in China in 2020 - Encheng Sun; Zhenjiang Zhang; Zilong Wang; Xijun He; Xianfeng Zhang; Lulu Wang; Wenqing Wang; Lianyu Huang; Fei Xi; Haoyue Huangfu; Ghebremedhin Tsegay; Hong Huo; et al. (Science China Life Sciences, 2021)

Taste Masking Study Based on an Electronic Tongue: the Formulation Design of 3D Printed Levetiracetam Instant-Dissolving Tablets - Zengming Wang; Jingru Li; Xiaoxuan Hong; Xiaolu Han; Boshi Liu; Xianfu Li; Hui Zhang; Jing Gao; Nan Liu; Xiang Gao; Aiping Zheng (Pharmaceutical Research, 2021)
Purpose Proper taste-masking formulation design is a critical issue for instant-dissolving tablets (IDTs). The purpose of this study is to use the electronic tongue to design the additives of the 3D printed IDTs to improve palatability. Methods A binder jet 3D printer was used to prepare IDTs of levetiracetam. A texture analyzer and dissolution apparatus were used to predict the oral dispersion time and in vitro drug release of IDTs, respectively. The palatability of different formulations was investigated using the ASTREE electronic tongue in combination with the design of experiment and a model for masking bitter taste. Human gustatory sensation tests were conducted to further evaluate the credibility of the results. Results The 3D printed tablets exhibited rapid dispersion (<30 s) and drug release (2.5 min > 90%). The electronic tongue had an excellent ability of taste discrimination, and levetiracetam had a good linear sensing performance based on a partial least square regression analysis. The principal component analysis was used to analyze the signal intensities of different formulations and showed that 2% sucralose and 0.5% spearmint flavoring masked the bitterness well and resembled the taste of corresponding placebo. The results of human gustatory sensation test were consistent with the trend of the electronic tongue evaluation. Conclusions Owing to its objectivity and reproducibility, this technique is suitable for the design and evaluation of palatability in 3D printed IDT development.

Clinical study on empirical and diagnostic-driven (pre-emptive) therapy of voriconazole in severe aplastic anaemia patients with invasive fungal disease after intensive immunosuppressive therapy - Yuhong Wu; Li Yan; Huaquan Wang; Hong Liu; Limin Xing; Rong Fu; Zonghong Shao (European Journal of Clinical Microbiology & Infectious Diseases, 2021)

Ongoing COVID-19 Pandemic: A Concise but Updated Comprehensive Review - Chao Wang; Xiong Xiao; Hongyan Feng; Zhengyuan Hong; Meng Li; Ning Tu; Xuerong Li; Ke Wang; Lihong Bu (Current Microbiology, 2021)

High-Dose Aluminum Exposure Further Alerts Immune Phenotype in Aplastic Anemia Patients - Yao Zuo; Xiang Lu; Xiaochao Wang; Suren R. Sooranna; Liju Tao; Shiqiang Chen; Hongwen Li; Dan Huang; Guanye Nai; Hong Chen; Chunfeng Pan; Caihong Huang; et al. (Biological Trace Element Research, 2021)
This study explored the relationship between immunological status and clinical characteristics of aplastic anemia (AA) patients to plasma aluminum levels, which were increased after constant exposure to high levels of this metal. Sixty-two AA patients (33 cases with high and 29 cases with low or no exposure to aluminum) and 30 healthy controls were selected for this study. Aluminum in human albumin solution was measured by inductivity coupled plasma mass spectrometry. IL-10, IL-12, IL-17, and INF-γ levels were measured by enzyme-linked immunosorbent assay. The distribution of lymphocyte subsets were determined by flow cytometry. The expression levels of immunoglobulins and complement C3 and C4 were also measured. Exposure to high aluminum raised the levels of serum aluminum in AA patients ( P < 0.01). The levels of hemoglobin and complement C4 were lower in AA patients with high aluminum exposure ( P < 0.05 and < 0.01, respectively). The percentage of CD4 + T cells and the ratio of CD4 + / CD8 + T cells in peripheral blood in AA patients with high aluminum exposure were higher compared with control AA patients ( P < 0.05 in both cases), while the percentage of CD8 + T cells was significantly lower than that in non-aluminum–exposed AA patients ( P < 0.05). Compared with non-aluminum–exposed AA patients, the level of IL-10 in the high aluminum–exposed AA group was significantly higher ( P < 0.05 in both cases). The immunological and clinical characteristics of AA patients from regions of high aluminum exposure are different to those in from non-aluminum areas. These results suggest that high aluminum exposure alters the immune system in patients suffering from AA.

Characteristics of soil erosion and sediment size distribution for different land uses in the Chinese Mollisol region - Hai-ou Shen; Jun Feng; Dong-li Wang; Hong-li Li; Yu Wang (Journal of Mountain Science, 2021)

B3GNT3 acts as a carcinogenic factor in endometrial cancer via facilitating cell growth, invasion and migration through regulating RhoA/RAC1 pathway-associated markers - Ji-Shui Wang; Fang Ruan; Li-Zhu Guo; Feng-Ge Wang; Fu-Ling Wang; Hong-Min An (Genes & Genomics, 2021)

Recent progress in induced pluripotent stem cell-derived 3D cultures for cardiac regeneration - Kai-Li Wang; Qi Xue; Xun-Hong Xu; Fang Hu; Hong Shao (Cell and Tissue Research, 2021)

The Roles of Epinephelus coioides miR-122 in SGIV Infection and Replication - Hong-Yan Sun; Yu-Ling Su; Pin-Hong Li; Jia-Yang He; He-Jia Chen; Gang Wang; Shao-Wen Wang; Xiao-Hong Huang; You-Hua Huang; Qi-Wei Qin (Marine Biotechnology, 2021)
In mammals, mature miR-122 is 22 nucleotides long and can be involved in regulating a variety of physiological and biological pathways. In this study, the expression profile and effects of grouper Epinephelus coioides miR-122 response to Singapore grouper iridovirus (SGIV) infection were investigated. The sequences of mature microRNAs (miRNAs) from different organisms are highly conserved, and miR-122 from E. coioides exhibits high similarity to that from mammals and other fish. The expression of miR-122 was up-regulated during SGIV infection. Up-regulation of miR-122 could significantly enhance the cytopathic effects (CPE) induced by SGIV, the transcription levels of viral genes (MCP, VP19, LITAF and ICP18), and viral replication; reduce the expression of inflammatory factors (TNF-a, IL-6, and IL-8), and the activity of AP-1 and NF-κB, and miR-122 can bind the target gene p38α MAPK to regulate the SGIV-induced cell apoptosis and the protease activity of caspase-3. The results indicated that SGIV infection can up-regulate the expression of E. coioides miR-122, and up-regulation of miR-122 can affect the activation of inflammatory factors, the activity of AP-1 and NF-κB, and cell apoptosis to regulate viral replication and proliferation.

COVID-19 illness and autoimmune diseases: recent insights - Juan Li; Hong-Hui Liu; Xiao-Dong Yin; Cheng-Cheng Li; Jing Wang (Inflammation Research, 2021)

An integrated regional water quality assessment method considering interrelationships among monitoring indicators - Yu Li; Xiao-Kang Wang; Hong-Yu Zhang; Jian-Qiang Wang; Lin Li (Environmental Monitoring and Assessment, 2021)

Increased depression risk for elderly women with high blood levels of strontium and barium - Jia Lv; Yan-ling Li; Wen-qiang Ren; Rong Li; Jian-rong Chen; Chao Bao; Zhi-ping Du; Shun Feng; Ling Gu; Hui Gao; Kai-yong Liu; Lin-sheng Yang; et al. (Environmental Chemistry Letters, 2021)

Correction to: Central Blockade of E-Prostanoid 3 Receptor Ameliorated Hypertension Partially by Attenuating Oxidative Stress and Inflammation in the Hypothalamic Paraventricular Nucleus of Spontaneously Hypertensive Rats - Fang-Fang Wang; Juan Bai; Xiao-Jing Yu; Xiao-Lian Shi; Jin-Jun Liu; Kai-Li Liu; Li-Yan Fu; Qing Su; Hong-Bao Li; Kai B. Kang; Qiu-Yue Yi; Shu-Qiu Wang; et al. (Cardiovascular Toxicology, 2021)

Central Blockade of E-Prostanoid 3 Receptor Ameliorated Hypertension Partially by Attenuating Oxidative Stress and Inflammation in the Hypothalamic Paraventricular Nucleus of Spontaneously Hypertensive Rats - Fang-Fang Wang; Juan Ba; Xiao-Jing Yu; Xiao-Lian Shi; Jin-Jun Liu; Kai-Li Liu; Li-Yan Fu; Qing Su; Hong-Bao Li; Kai B. Kang; Qiu-Yue Yi; Shu-Qiu Wang; et al. (Cardiovascular Toxicology, 2021)

Polymorphisms in the DC-SIGN gene and their association with the severity of hand, foot, and mouth disease caused by enterovirus 71 - Ya-Ping Li; Mu-Qi Wang; Chen-Rui Liu; Hui-Ling Deng; Yuan Wu; Shuang-Suo Dang; Li-Hong Xu (Archives of Virology, 2021)

Complex microbial communities inhabiting natural Cordyceps militaris and the habitat soil and their predicted functions - Xiao-Mei Zhang; De-Xiang Tang; Qing-Qing Li; Yuan-Bing Wang; Zhi-Hong Xu; Wen-Jun Li; Hong Yu (Antonie van Leeuwenhoek, 2021)

Correction to: P2Y12 receptor upregulation in satellite glial cells is involved in neuropathic pain induced by HIV glycoprotein 120 and 2',3'-dideoxycytidine - Zhihua Yi; Lihui Xie; Congfa Zhou; Huilong Yuan; Shuai Ouyang; Zhi Fang; Shanhong Zhao; Tianyu Jia; Lifang Zou; Shouyu Wang; Yun Xue; Bing Wu; et al. (Purinergic Signalling, 2021)

Mitogen-activated protein kinase 11 (MAPK11) maintains growth and photosynthesis of potato plant under drought condition - Xi Zhu; Ning Zhang; Xue Liu; Shigui Li; Jiangwei Yang; Xusheng Hong; Fangfang Wang; Huaijun Si (Plant Cell Reports, 2021)

Thiazole-based and thiazolidine-based protein tyrosine phosphatase 1B inhibitors as potential anti-diabetes agents - Kexin Chen; Xu Yao; Ting Tang; Li-Mei Chen; Can Xiao; Jing-Yi Wang; Hong-Fei Chen; Zhong-Xing Jiang; Yi Liu; Xing Zheng (Medicinal Chemistry Research, 2021)

Traditional Chinese medicines and their active ingredients sensitize cancer cells to TRAIL-induced apoptosis - Bingyu Sun; Yongqiang Liu; Danhua He; Jinke Li; Jiawei Wang; Wulin Wen; Ming Hong (Journal of Zhejiang University-SCIENCE B, 2021)

Integrity investigation of global ionospheric TEC maps for high-precision positioning - Jiaojiao Zhao; Manuel Hernández-Pajares; Zishen Li; Ningbo Wang; Hong Yuan (Journal of Geodesy, 2021)
Aside from the ionospheric total electron content (TEC) information, root-mean-square (RMS) maps are also provided as the standard deviations of the corresponding TEC errors in global ionospheric maps (GIMs). As the RMS maps are commonly used as the accuracy indicator of GIMs to optimize the stochastic model of precise point positioning algorithms, it is of crucial importance to investigate the reliability of RMS maps involved in GIMs of different Ionospheric Associated Analysis Centers (IAACs) of the International GNSS Service (IGS), i.e., the integrity of GIMs. We indirectly analyzed the reliability of RMS maps by comparing the actual error of the differential STEC (dSTEC) with the RMS of the dSTEC derived from the RMS maps. With this method, the integrity of seven rapid IGS GIMs (UQRG, CORG, JPRG, WHRG, EHRG, EMRG, and IGRG) and six final GIMs (UPCG, CODG, JPLG, WHUG, ESAG and IGSG) was examined under the maximum and minimum solar activity conditions as well as the geomagnetic storm period. The results reveal that the reliability of the RMS maps is significantly different for the GIMs from different IAACs. Among these GIMs, the values in the RMS maps of UQRG are large, which can be used as ionospheric protection level, while the RMS values in EHRG and ESAG are significantly lower than the realistic RMS. The rapid and final GIMs from CODE, JPL and WHU provide quite reasonable RMS maps. The bounding performance of RMS maps can be influenced by the location of the stations, while the influence of solar activity and the geomagnetic storm is not obvious.

Efficient Editing of an Adenoviral Vector Genome with CRISPR/Cas9 - Qiang Li; Hui Wang; Chen-yu Gong; Zhao Chen; Jia-xing Yang; Hong-wei Shao; Wen-feng Zhang (Indian Journal of Microbiology, 2021)

Comprehensive upstream and downstream regulatory analyses identify miR-675-3p as a potential prognostic biomarker in melanoma - Cai-Chou Zhao; Hao Guo; Ying Wang; Jiu-Hong Li (Human Cell, 2021)
This study assessed miR-675-3p-related regulatory mechanisms in melanoma and the clinical relevance of such regulatory activities. We downloaded miRNA mature strand expression RNA-Seq, phenotypic, and DNA methylation data pertaining to the TCGA Melanoma cohort. Differentially expressed miRNAs (DEMs) between metastatic and primary melanoma patient tissues were then identified, and miR-675-3p expression in melanoma patient peripheral blood was confirmed using the GSE20994 GEO dataset, while its expression in melanoma cell lines was evaluated via qRT-RCR. The clinical and prognostic implications of miR-675-3p in melanoma were assessed, and miR-675-3p target genes were identified using bioinformatics tools. Functional roles of this miRNA were explored via Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses. We identified 3 and 22 miRNAs that were up- and downregulated, respectively, in metastatic melanoma samples relative to primary melanoma samples. Upregulation of miR-675-3p was associated with poorer overall patient survival, tumor histologic grade, and Clark's level. Consistently, miR-675-3p was also overexpressed in the peripheral blood of melanoma patients relative to healthy controls, and in melanoma cell lines relative to control cells. Gene regulatory networks indicated that 32 transcription factors control miR-675-3p expression, and that it, in turn, regulates 10 target genes. KEGG analyses indicated that these genes were associated with cell cycle, transcriptional misregulation in cancer, TGF-beta signaling, and HIF-1 signaling pathways. Gain-of-function assays revealed that miR-675-3p could promote cell proliferation via accelerating cell cycle progression. Western blotting results indicated that miR-675-3p could active TGF-beta and HIF-1 signaling. Through upstream and downstream analyses of miR-675-3p-related regulatory activity, we confirmed that this miRNA participates in key melanoma-related processes and offers value as a prognostic biomarker in melanoma patients.

Genome surveying reveals the complete chloroplast genome and nuclear genomic features of the crocin-producing plant Gardenia jasminoides Ellis - Wencai Wang; Fengqing Shao; Xin Deng; Yuanwei Liu; Siyun Chen; Yongquan Li; Wei Guo; Qingbin Jiang; Hong Liang; Xianzhi Zhang (Genetic Resources and Crop Evolution, 2021)

Experimental study on permeability characteristics and radon exhalation law of overburden soil in uranium tailings pond - Xiaolu Liu; Xiangyang Li; Ming Lan; Yong Liu; Changshou Hong; Hong Wang (Environmental Science and Pollution Research, 2021)

Genetic diversity analysis of Topmouth Culter (Culter alburnus) based on microsatellites and D-loop sequences - Ning Sun; Dong-Mei Zhu; Qing Li; Gui-Ying Wang; Jian Chen; Feifei Zheng; Pei Li; Yan-Hong Sun (Environmental Biology of Fishes, 2021)

Bacillus alkalicellulosilyticus sp. nov., isolated from extremely alkaline bauxite residue (red mud) site - Guo-Hong Liu; Manik Prabhu Narsing Rao; Xiao-Ying Wang; Tong-Wei Chu; Bo Liu; Wen-Jun Li (Archives of Microbiology, 2021)

Lentibacillus saliphilus. sp. nov., a moderately halophilic bacterium isolated from a saltern in Korea - Yun Wang; Gang-Qiang Jiang; Hong-Ping Lin; Peng Sun; Hong-Yan Zhang; Dong-Mei Lu; Li-Yun Wang; Chang-Jin Kim; Shu-Kun Tang (Archives of Microbiology, 2021)

Measuring solar irradiance profiles in the Arctic sea ice using fiber optic spectrometry via inclined holes - Zexia Qiu; Hangzhou Wang; Tao Li; Hong Song; Yuanqian Wu; Tingting Yan; Ying Chen (Acta Oceanologica Sinica, 2021)

MiR-126-3p-Enriched Extracellular Vesicles from Hypoxia-Preconditioned VSC 4.1 Neurons Attenuate Ischaemia-Reperfusion-Induced Pain Hypersensitivity by Regulating the PIK3R2-Mediated Pathway - He Wang; Feng-Shou Chen; Zai-Li Zhang; Hong-Xu Zhou; Hong Ma; Xiao-Qian Li (Molecular Neurobiology, 2021)

Interaction between piperine and genes associated with sciatica and its mechanism based on molecular docking technology and network pharmacology - Jiu-wang Yu; Hong-wei Yuan; Li-dao Bao; Leng-ge Si (Molecular Diversity, 2021)
Piperine is the main active component of Piper longum L., which is also the main component of anti-sciatica Mongolian medicine Naru Sanwei pill. It has many pharmacological activities such as anti-inflammatory and immune regulation. This paper aims to preliminarily explore the potential mechanism of piperine in the treatment of sciatica through network pharmacology and molecular docking. TCMSP, ETCM database and literature mining were used to collect the active compounds of Piper longum L. Swiss TargetPrediction and SuperPred server were used to find the targets of compounds. At the same time, CTD database was used to collect the targets of sciatica. Then the above targets were compared and analyzed to select the targets of anti-sciatica in Piper longum L. The Go (gene ontology) annotation and KEGG pathway of the targets were enriched and analyzed by Metascape database platform. The molecular docking between the effective components and the targets was verified by Autodock. After that, the sciatica model of rats was established and treated with piperine. The expression level of inflammatory factors and proteins in the serum and tissues of rat sciatic nerve were detected by ELISA and Western blot. HE staining and immunohistochemistry were carried out on the sciatica tissues of rats. The results showed that Piper longum L. can regulate the development of sciatica and affect the expressions of PPARG and NF-kB1 through its active ingredient piperine, and there is endogenous interaction between PPARG and NF-kB1. Graphic abstract

Preliminary report on the improved resistance towards Pseudomonas syringae pv. actinidiae of cultivated kiwifruit (Actinidia chinensis) when grafted onto wild Actinidia guilinensis rootstock in vitro - Fa-ming Wang; Jie-wei Li; Kai-yu Ye; Hong-juan Gong; Ping-ping Liu; Qiao-sheng Jiang; Bei-bei Qi; Quan-hui Mo (Journal of Plant Pathology, 2021)

RNA sequencing reveals BMP4 as a basis for the dual-target treatment of diabetic retinopathy - Lijie Dong; Zhe Zhang; Xun Liu; Qiong Wang; Yaru Hong; Xiaorong Li; Juping Liu (Journal of Molecular Medicine, 2021)

Expression of G9a in Auditory Cortex Is Downregulated in a Rat Model of Age-Related Hearing Loss - Qian Li; Yang-hong Xiang; Xiao-jun Liang; Yun Zhang; Peng-peng Zhao; Min Wang; Xiao-min Bao; Xian-bai Zhu; An-chun Deng (Journal of Molecular Neuroscience, 2021)

TRIP13 promotes the proliferation and invasion of lung cancer cells via the Wnt signaling pathway and epithelial–mesenchymal transition - Zhi-Han Li; Lei Lei; Liang-Ru Fei; Wen-Jing Huang; Yi-Wen Zheng; Mai-Qing Yang; Zhao Wang; Chen-Chen Liu; Hong-Tao Xu (Journal of Molecular Histology, 2021)

Seasonal rainfall patterns in stable carbon isotopes in the Mu Us Desert, northern China during the early and middle Holocene - Peixian Shu; Hong Wang; Weijian Zhou; Hong Ao; Dongfeng Niu; Xiaohao Wen; Baosheng Li (Climate Dynamics, 2021)

Different resistance potential to reovirus in grass carp (Ctenopharyngodon idella) populations and their immune characteristics - Hongquan Wang; Hong Yang; Rui Li; Yaoguo Li; Tiaoyi Xiao (Aquaculture International, 2021)

Retraction Note to: NPC-16, a novel naphthalimide–polyamine conjugate, induced apoptosis and autophagy in human hepatoma HepG2 cells and Bel-7402 cells - Song-qiang Xie; Qian Li; Ya-hong Zhang; Jian-hong Wang; Zi-hou Mei; Jin Zhao; Chao-jie Wang (Apoptosis, 2021)

Insights into the aridification history of Central Asian Mountains and international conservation strategy from the endangered wild apple tree - Hong‐Xiang Zhang; Xiao‐Shuang Li; Jian‐Cheng Wang; Dao‐Yuan Zhang (Journal of Biogeography, 2021)
Aim Evolutionary processes of mountain plants in arid lands remain poorly understood. Here, we investigate population genomics of the endangered wild apple tree to interpret the effects of long‐term aridification on plant diversification and demographical history in Central Asian Mountains. Location The Tianshan Mountains, spanning north‐western China, Kazakhstan, Kyrgyzstan and Tajikistan. Taxon Malus sieversii (Rosaceae) Methods Using genome‐wide single nucleotide polymorphisms, we assessed genetic diversity and genetic structure of 15 populations across the species' range. Demographical history was simulated with approximate Bayesian computation and species distribution modelling. We used a general linear model to identify key environmental factors affecting population genetic diversity and structure. Results We separated the 15 populations into three groups: the eastern group of western Junggar Mountains in China; the central group of the Ili Valley, the Talas Alatau Mountains in Kazakhstan and Kyrgyzstan; and the western group of Tajikistan and the Dzungarian Alatau in Kazakhstan. Central populations had higher genetic diversity and effective population size than eastern and western populations. The three groups split at the late Miocene and subsequently experienced extensive admixture. We detected a significant pattern of isolation by distance, but not isolation by environment, among these populations. Population genetic diversity was significantly associated with longitudinal and current environmental gradients. Main conclusions Long‐term aridification promoted distribution fragmentation and plant lineage divergence of relict broad‐leaved forests in Central Asian Mountains. Both geographical isolation and environmental heterogeneity shaped spatial patterns in genetic variation among M. sieversii populations. To maintain genetic integrity, we propose the establishment of an international network for the conservation of this endangered wild apple tree.

Leading modes of Asian–Australian monsoon interannual variability as represented in CMIP5 models - Fang Zhou; Hong‐Li Ren; Ming‐Hong Liu; Run Wang; Kai Huang (International Journal of Climatology, 2021)
The Asian–Australian monsoon (AAM) exerts a strong impact on the regional climate. The ability of climate models to simulate the AAM is of great importance. This study evaluates the performance of 26 models, which participate in the Coupled Model Intercomparison Project phase 5 (CMIP5), in representing features of the leading modes of the AAM interannual variability. This is achieved by diagnosing quantitative metrics derived from a Season‐reliant Empirical Orthogonal Function (S‐EOF) analysis, and plausible external forcing contributing to the simulation results are presented. Our results show that the CMIP5 models can generally capture the spatial patterns of the leading modes of AAM interannual variability during El Niño development periods because of strong air–sea interactions. The variance percentage explained by the first two S‐EOF modes is found to be closely related to the amplitude of the El Niño‐Southern Oscillation (ENSO) in the models. In contrast, simulation of the periodicity remains challenging, and the models show deficiencies in the accurate capture of periodic characteristics. Models with realistic ENSO simulations typically perform well in simulating S‐EOF1, and the key to improving the simulation of S‐EOF2 is the greater intensity of the simulated field of background heating over the Northwest Pacific warm pool. The multimodel ensemble (MME) performs better than most of the 26 individual models. Models in the MME with better ENSO simulation and stronger warm pool heating are found to be better able to represent the relationships between the first two leading S‐EOF modes and ENSO, although biases remained.

Community structure of bacterioplankton and its relationship with environmental factors in the upper reaches of the Heihe River in Qinghai Plateau - Zhang Qian‐Qian; Jian Sheng‐Long; Li Ke‐Mao; Wu Zhen‐Bing; Guan Hong‐Tao; Hao Jin‐Wen; Wang Shu‐Yi; Lin Yao‐Yao; Wang Guo‐Jie; Li Ai‐Hua (Environmental Microbiology, 2021)
Summary Planktonic microorganisms play a key role in the biogeochemical processes of the aquatic system, and they may be affected by many factors. High‐throughput sequencing technology was used in this study to investigate and study the bacterioplankton community of water bodies in the upper reaches of the Heihe River Basin in Qinghai Plateau. Results showed that Proteobacteria, Firmicutes, Bacteroidetes and Actinobacteria are the predominant phyla in this river section, while the main genera are Thiomonas , Acidibacillus , Acidocella , Rhodanobacter , Acidithiobacter and Gallionella , which are autochthonous in the acid‐mine drainage. Additionally, total nitrogen, total phosphorus, permanganate index and pH are significantly correlated with the bacterioplankton abundance and are the main limiting factors for the spatial distribution of the bacterioplankton. PICRUSt inferred that the mainstream microbial assemblages had a higher abundance of KOs belong to metabolism of terpenoids and polyketides, while the tributary had higher abundance of KOs belong to the immune system. The relationship between bacterioplankton community composition and environmental factors in the Heihe River basin was discussed for the first time in this study, which provides a theoretical basis for the healthy, orderly development of the water environment in the Heihe River Basin.

PapA , a peptidoglycan‐associated protein, interacts with OmpC and maintains cell envelope integrity - Yun‐Hao Wang; Hong‐He Chen; Zhou Huang; Xiao‐Jing Li; Nan Zhou; Chang Liu; Cheng‐Ying Jiang; De‐Feng Li; Shuang‐Jiang Liu (Environmental Microbiology, 2021)
Summary The bacterial cell envelope is critical to support and maintain cellular life. In Gram‐negative bacterial cells, the outer membrane and the peptidoglycan layer are two important parts of the cell envelope and they harbour abundant proteins. Here, we report the identification and characterization of a previously unknown p eptidoglycan‐ a ssociated p rotein, PapA, from the Gram‐negative Comamonas testosteroni . PapA bound peptidoglycan with its C‐terminal domain and interacted with the outer‐membrane porin OmpC. The PapA‐OmpC complex riveted the outer membrane and the peptidoglycan layer, and played a role in maintaining cell envelope integrity. When papA was disrupted, the mutant CNB‐1Δ papA apparently had an outer membrane partly separated from the peptidoglycan layer. Phenotypically, the mutant CNB‐1Δ papA lost chemotactic responses and had longer lag‐phase of growth, less flagellation and higher sensitivity to harsh environments. Totally, 1093 functionally unknown PapA homologues were identified from the public NR protein database and they were mainly distributed in Burkholderiales of Betaproteobacteria. Our finding provides a clue that the PapA homologous proteins might function as a rivet to maintain cell envelope integrity in those Gram‐negative bacteria.

Diterpenoid and triterpenoid glycosides from Clinopodium chinense - Ling-Xia Qu; Yong-Qiao Liu; Yang Wang; Hong Wang; Xue-Li Huang; Mei-Ling Zhang; Yong-Xiao Mou; Tun-Hai Xu; Yin-Di Zhu (Natural Product Research, 2021)

FED: a web tool for foreign element detection of genome-edited organism - Qing Liu; Xiaozhen Jiao; Xiangbing Meng; Chun Wang; Cao Xu; Zhixi Tian; Chuanxiao Xie; Genying Li; Jiayang Li; Hong Yu; Kejian Wang (Science China Life Sciences, 2021)

IbERF71, with IbMYB340 and IbbHLH2, coregulates anthocyanin accumulation by binding to the IbANS1 promoter in purple-fleshed sweet potato (Ipomoea batatas L.) - Zhiyuan Ning; Kangdi Hu; Zhilin Zhou; Donglan Zhao; Jun Tang; Hong Wang; Lixia Li; Chen Ding; Xiaoyan Chen; Gaifang Yao; Hua Zhang (Plant Cell Reports, 2021)

Effect of elevated CO2 on the population development of the invasive species Frankliniella occidentalis and native species Thrips hawaiiensis and activities of their detoxifying enzymes - Yu Cao; Hong Yang; Yulin Gao; Lijuan Wang; Jun Li; Chun Wang; Can Li (Journal of Pest Science, 2021)

Willingness of rural residents to pay for clean coal and stoves in winter: an empirical study from Zoucheng, Shandong - Jiaqi Wang; Ruyin Long; Hong Chen; Qianwen Li (Environmental Science and Pollution Research, 2021)

A review on Cadmium Exposure in the Population and Intervention Strategies Against Cadmium Toxicity - Mei Wang; Zhaofang Chen; Wei Song; Dezi Hong; Lei Huang; Yunhui Li (Bulletin of Environmental Contamination and Toxicology, 2021)

Correction to: The effects of soil shrinkage during centrifuge tests on SWCC and soil microstructure measurements - Lincui Li; Xi-An Li; Li Wang; Bo Hong; Jianfeng Shi; Jianqiang Sun (Bulletin of Engineering Geology and the Environment, 2021)

Artificial Neural Network-based prediction of glacial debris flows in the ParlungZangbo Basin, southeastern Tibetan Plateau, China - Wang Tang; Hai-tao Ding; Ning-sheng Chen; Shang-Chang Ma; Li-hong Liu; Kang-lin Wu; Shu-feng Tian (Journal of Mountain Science, 2021)

Complete genome sequence of the extreme-pH-resistant Salmonella bacteriophage αα of the family Microviridae - Mengzhe Li; Hong Lin; Luokai Wang; Jingxue Wang (Archives of Virology, 2021)

Phylogeny of Veneridae (Bivalvia) based on mitochondrial genomes - Yu Wang; Yi Yang; Hongyue Liu; Lingfeng Kong; Hong Yu; Shikai Liu; Qi Li (Zoologica Scripta, 2021)
Veneridae is one of the most diverse families of bivalve molluscs. However, their phylogenetic relationships among subfamilies have been debated for years. To explore phylogenetic relationships of Veneridae, we sequenced 13 complete mitochondrial genome sequences from eight subfamilies and compared with available complete mitochondrial genome of other Veneridae taxa (18 previously reported sequences). Phylogenetic analyses using probabilistic methods recovered two highly supported clades. In addition, the protein‐coding gene order revealed a highly conserved pattern among the same subclade lineages. According to our molecular analyses, Tapetinae should be recognized as a valid subfamily, but the genera formed para‐polyphyletic clades. Chioninae was recovered not monophyletic that differs from a previously molecular phylogeny. Furthermore, the reconstructed chronogram calibrated with fossils recovered the Veneridae have originated during the early Permian (about 290 million years ago). Noticeably, programmed frameshift was found in the nad4 gene of Leukoma jedoensis , Anomalodiscus squamosus and Antigona lamellaris and cob gene of L. jedoensis . This is the first time that the presence of the programmed frameshift has been found in the protein‐coding genes of Heterodonta species. Our results improved the phylogenetic resolution within Veneridae, and a more taxonomic sampling analysis of the subfamily Chioninae is supposed to construct.

Observed trends of different rainfall intensities and the associated spatiotemporal variations during 1958–2016 in Guangxi , China - Nian Xiu Qin; Jun Neng Wang; Liang Gao; Yang Hong; Jia Li Huang; Qin Qin Lu (International Journal of Climatology, 2021)
In a changing climate, drought and flood hazards become more frequent, posing high risks to human life and property. The Guangxi Zhuang Autonomous Region is selected as the study area. The flood and drought records, and the daily precipitation data at 23 stations from 1958 to 2016 are adopted. The temporal and spatial trends of precipitation intensities, precipitation days and the corresponding proportions relative to the total amounts are examined using the Mann‐Kendall trend test. The influence of the rainfall intensity on floods and droughts in Guangxi is also investigated. During the past 59 years in Guangxi, there is a significant decrease in light rain, and an increase in rainstorm in general. The larger the rainfall intensity is, the more stations show increasing trends of the corresponding rain events on different time scales (the monthly, seasonal or annual scale). Significant decreasing trends of the number of days with light precipitation are found over entire Guangxi, while increasing trends of the number of days with rainstorm events are widely distributed in most parts of Guangxi. There is a decrease in the number of stations indicating increases in proportion of light precipitation days, while an increase in the number of stations showing increases in proportion of rainstorm days. A significant increase in flood hazards is detected since the 1990s. The precipitation in Guangxi tends to be intensified in the future. The frequency and intensity of drought and flood events are very likely to increase, posing challenges to future agricultural production, water resources planning and management.

Phytochemical and antitumor studies on Cynanchum mongolicum (Maxim.) Kom - Yong-Cheng Yang; Yan-Ming Wang; Zi-Jian Rong; Li-Na Hong; Qian Zhang; Jing-Ming Jia; An-Hua Wang (Natural Product Research, 2020)

Phytochemical constituents, chemotaxonomic significance and anti-arthritic effect of Eucommia ulmoides Oliver staminate flowers - Rui Li; Lanlan Nie; Qing Wang; Danwei Ouyang; Lei Zhang; Ying Yuan; Yanlong Hong; Jianying Wang; Xiao Hu (Natural Product Research, 2020)

Correction to: The effect of teprenone on the intestinal morphology and microbial community of Chinese sea bass (Lateolabrax maculatus) under intermittent hypoxic stress - Hong-biao Dong; Yong-xu Sun; Ya-fei Duan; Hua Li; Yong Li; Qing-song Liu; Wen-hao Wang; Jia-song Zhang (Fish Physiology and Biochemistry, 2020)

Geographical origin differentiation of Chinese Angelica by specific metal element fingerprinting and risk assessment - Lei Sun; Xiao Ma; Hong-Yu Jin; Chang-jun Fan; Xiao-dong Li; Tian-Tian Zuo; Shuang-Cheng Ma; Sicen Wang (Environmental Science and Pollution Research, 2020)

The extract of aquatic macrophyte Carex cinerascens induced colony formation in bloom-forming cyanobacterium Microcystis aeruginosa - Lin Li; Xiao-ling Jing; Ling Wang; Zhi-gao Zeng; Wen-hong Chen; Jia-hao Zhai; Si-qin Qi (Environmental Science and Pollution Research, 2020)

Induced sputum metabolomic profiles and oxidative stress are associated with chronic obstructive pulmonary disease (COPD) severity: potential use for predictive, preventive, and personalized medicine - Tao Zhu; Shanqun Li; Jiajia Wang; Chunfang Liu; Lei Gao; Yuzhen Zeng; Ruolin Mao; Bo Cui; Hong Ji; Zhihong Chen (EPMA Journal, 2020)
Chronic obstructive pulmonary disease (COPD) is a highly heterogeneous disease, and metabolomics plays a hub role in predictive, preventive, and personalized medicine (PPPM) related to COPD. This study thus aimed to reveal the role of induced sputum metabolomics in predicting COPD severity. In this pilot study, a total of 20 COPD patients were included. The induced sputum metabolites were assayed using a liquid chromatography-mass spectrometry (LC-MS/MS) system. Five oxidative stress products (myeloperoxidase (MPO), superoxide dismutase (SOD), glutathione (GSH), neutrophil elastase (NE), and 8-iso-PGF2α) in induced sputum were measured by ELISA, and the metabolomic profiles were distinguished by principal component analysis (PCA) and orthogonal projections to latent structures discriminant analysis (OPLS-DA). The Kyoto Encyclopedia of Genes and Genomes (KEGG) was used for pathway enrichment analysis, and a significant difference in induced sputum metabolomics was observed between moderate and severe COPD. The KEGG analysis revealed that the glycerophospholipid metabolism pathway was downregulated in severe COPD. Due to the critical role of glycerophospholipid metabolism in oxidative stress, significant negative correlations were discovered between glycerophospholipid metabolites and three oxidative stress products (SOD, MPO, and 8-iso-PGF2α). The diagnostic values of SOD, MPO, and 8-iso-PGF2α in induced sputum were found to exhibit high sensitivities and specificities in the prediction of COPD severity. Collectively, this study provides the first identification of the association between induced sputum metabolomic profiles and COPD severity, indicating the potential value of metabolomics in PPPM for COPD management. The study also reveals the correlation between glycerophospholipid metabolites and oxidative stress products and their value for predicting COPD severity.

Pollution characteristics of phthalate acid esters in agricultural soil of Yinchuan, northwest China, and health risk assessment - Hong Tao; Yajuan Wang; Haohua Liang; Xiaohong Zhang; Xiaopeng Liu; Jiaoling Li (Environmental Geochemistry and Health, 2020)

Using sowing date management to promote micronutrient quality and alleviate cadmium accumulation in rice grains - Lin-lin Shi; Ming-xing Shen; Hong-jun Wu; Chang-ying Lu; Li-juan Mei; Xin-lian Zhu; Hai-hou Wang; Yun-Sheng Song (Cereal Research Communications, 2020)

Characterization, modes of action, and application of a novel broad-spectrum bacteriocin BM1300 produced by Lactobacillus crustorum MN047 - Yingying Lu; Rakhmanova Aizhan; Hong Yan; Xin Li; Xin Wang; Yanglei Yi; Yuanyuan Shan; Bianfang Liu; Yuan Zhou; Xin Lü (Brazilian Journal of Microbiology, 2020)

Voxel-based morphometry results in first-episode schizophrenia: a comparison of publicly available software packages - Chen Li; Wenming Liu; Fan Guo; Xingrui Wang; Xiaowei Kang; Yongqiang Xu; Yibin Xi; Huaning Wang; Yuanqiang Zhu; Hong Yin (Brain Imaging and Behavior, 2020)

Characterization and genome analysis of Klebsiella phage P509, with lytic activity against clinical carbapenem-resistant Klebsiella pneumoniae of the KL64 capsular type - Min Li; Yuyi Xiao; Pei Li; Zitong Wang; Weiling Qi; Zitai Qi; Liang Chen; Hong Du; Wei Zhang (Archives of Virology, 2020)

On the characterization of the shrinkage behavior and soil-water retention curves of four soils using centrifugation and their relation to the soil structure - Lincui Li; Xi-An Li; Haonan Lei; Bo Hong; Li Wang; Hong Zheng (Arabian Journal of Geosciences, 2020)

Application of multi-component joint inversion in oil and gas exploration: A case study of reservoir and gas saturation prediction of the Xujiahe formation in the PLN area of the central Sichuan Basin - Dong Wang; Zhen-Hua He; Xu-Ben Wang; Le Li; Hai-Tao Yang; Zhi-Guo Fu; Hong-Yan Wang (Applied Geophysics, 2020)

Influence of complex topography on magnetotelluric-observed data using three-dimensional numerical simulation: A case from Guangxi area, China - Xiong Bin; Luo Tian-Ya; Chen Long-Wei; Dai Shi-Kun; Xu Zhi-Feng; Li Chang-Wei; Ding Yan-Li; Wang Hong-Hua; Li Jing-He (Applied Geophysics, 2020)

Unsupervised seismic facies analysis using sparse representation spectral clustering - Wang Yao-Jun; Wang Liang-Ji; Li Kun-Hong; Liu Yu; Luo Xian-Zhe; Xing Kai (Applied Geophysics, 2020)

Decreased serum albumin level indicates poor prognosis of COVID-19 patients: hepatic injury analysis from 2,623 hospitalized cases - Wei Huang; Chenze Li; Zhiquan Wang; Hong Wang; Ning Zhou; Jiangang Jiang; Li Ni; Xin A. Zhang; Dao-Wen Wang (Science China Life Sciences, 2020)

Influence of near-fault ground motion characteristics on the seismic response of cable-stayed bridges - Chao Zhang; Jian-bing Lu; Hong-yu Jia; Zhi-chao Lai; Xu Li; Pi-guang Wang (Bulletin of Earthquake Engineering, 2020)

Inhibition of nattokinase against the production of poly (γ-glutamic Acid) in Bacillus subtilis natto - Li Wang; Ning Liu; Chenrui Yu; Junliu Chen; Kangjin Hong; Yipeng Zang; Mengmeng Wang; Guangjun Nie (Biotechnology Letters, 2020)

Correction to: Application of a Bayesian Watershed Model Linking Multivariate Statistical Analysis to Support Watershed-Scale Nitrogen Management in China - Jian Sha; Zeli Li; Dennis P. Swaney; Bongghi Hong; Wei Wang; Yuqiu Wang (Water Resources Management, 2020)

Co-expression network analysis uncovers key candidate genes related to the regulation of volatile esters accumulation in Woodland strawberry - Zekun Li; Zhennan Wang; Kejing Wang; Yue Liu; Yanhong Hong; Changmei Chen; Xiayu Guan; Qingxi Chen (Planta, 2020)

Liquiritin inhibits proliferation and induces apoptosis in HepG2 hepatocellular carcinoma cells via the ROS-mediated MAPK/AKT/NF-κB signaling pathway - Jia-Ru Wang; Tian-Zhu Li; Cheng Wang; Shu-Mei Li; Ying-Hua Luo; Xian-Ji Piao; Yu-Chao Feng; Yi Zhang; Wan-Ting Xu; Yu Zhang; Tong Zhang; Shi-Nong Wang; et al. (Naunyn-Schmiedeberg's Archives of Pharmacology, 2020)

ATP-binding cassette g1 regulates osteogenesis via Wnt/β-catenin and AMPK signaling pathways - Lei Zhou; Shiwei Sun; Tieqi Zhang; Yueming Yu; Liang Xu; Haoran Li; Minghai Wang; Yang Hong (Molecular Biology Reports, 2020)

Leptin promotes endothelial dysfunction in chronic kidney disease by modulating the MTA1-mediated WNT/β-catenin pathway - Bing Liu; Jiao Qiao; Jinxiu Hu; Minghua Fan; Yanfang Zhao; Hong Su; Ziyang Wang; Qun Yu; Qiqi Ma; Yanmei Li; Zhimei Lv; Rong Wang (Molecular and Cellular Biochemistry, 2020)

The effect of teprenone on the intestinal morphology and microbial community of Chinese sea bass (Lateolabrax maculatus) under intermittent hypoxic stress - Hong-biao Dong; Yong-xu Sun; Ya-fei Duan; Hua Li; Yong Li; Qing-song Liu; Wen-hao Wang; Jia-song Zhang (Fish Physiology and Biochemistry, 2020)

Effects of biochar properties on the bioremediation of the petroleum-contaminated soil from a shale-gas field - Hong-Yang Ren; Zi-Jing Wei; Yan Wang; Yuan-Peng Deng; Ming-Yu Li; Bing Wang (Environmental Science and Pollution Research, 2020)

Phaeotremella camelliae sp. nov. (Phaeotremellaceae, Tremellales), A Novel Yeasts Isolated from Tea-Oil Fruits in Jiangxi Province, China - Yong Sun; Gui-Shuang Wang; Ai-Hua Li; Wangmu; Xian-Qiu Chui; Ji-Hong Jiang; Qi-Ming Wang (Current Microbiology, 2020)

Piperine inhibits colorectal cancer migration and invasion by regulating STAT3/Snail-mediated epithelial–mesenchymal transition - Lingyu Song; Yan Wang; Yunhuan Zhen; Dengke Li; Xidong He; Hong Yang; Huayang Zhang; Qi Liu (Biotechnology Letters, 2020)

The neural mechanisms of immediate and follow-up of the treatment effect of hypnosis on smoking craving - Xiaoming Li; Lijun Chen; Ru Ma; Haibao Wang; Li Wan; Junjie Bu; Wei Hong; Wanwan Lv; Yihong Yang; Hengyi Rao; Xiaochu Zhang (Brain Imaging and Behavior, 2020)

Comparative iTRAQ Proteomics Reveals Multiple Effects of Selenium Yeast on Dairy Cows in Parturition - Zhi-hua Ren; Li-peng Bai; Liu-hong Shen; Zheng-zhong Luo; Zi-han Zhou; Zhi-cai Zuo; Xiao-ping Ma; Jun-liang Deng; Ya Wang; Sheng-yu Xu; Yu-heng Luo; Sui-zhong Cao; et al. (Biological Trace Element Research, 2020)

Transcriptome analysis of rice leaves in response to Rhizoctonia solani infection and reveals a novel regulatory mechanism - De Peng Yuan; Xiao Feng Xu; Woo-Jong Hong; Si Ting Wang; Xin Tong Jia; Yang Liu; Shuang Li; Zhi Min Li; Qian Sun; Qiong Mei; Shuai Li; Ki-Hong Jung; et al. (Plant Biotechnology Reports, 2020)

Stability analysis of an unsaturated soil slope considering rainfall infiltration based on the Green-Ampt model - Zi-zhen Liu; Zhi-xin Yan; Zhan-hong Qiu; Xiao-gang Wang; Ji-wei Li (Journal of Mountain Science, 2020)

Structural characteristics and anti-complement activities of polysaccharides from Sargassum hemiphyllum - Weihua Jin; Qiufu Fang; Di Jiang; Tongtong Li; Bin Wei; Jiadong Sun; Wenjing Zhang; Zhongshan Zhang; Fuming Zhang; Robert J. Linhardt; Hong Wang; Weihong Zhong (Glycoconjugate Journal, 2020)

Optimization of Rural Settlement Distributions Based On the Ecological Security Pattern: A Case Study of Da’an City in Jilin Province of China - Jingbo Yin; Hong Li; Dongyan Wang; Shuhan Liu (Chinese Geographical Science, 2020)

Comparison of mRNA Expression of P2X Receptor Subtypes in Different Arterial Tissues of Rats - Ling-Zhi Li; Li-Hui Yue; Zhi-Min Zhang; Jing Zhao; Lei-Ming Ren; Hong-Jie Wang; Lu Li (Biochemical Genetics, 2020)

A new ocotillol-type ginsenoside from stems and leaves of Panax quinquefolium L. and its anti-oxidative effect on hydrogen peroxide exposed A549 cells - Zeng Qi; Zhenzhou Wang; Baisong Zhou; Shuilian Fu; Tie Hong; Pingya Li; Jinping Liu (Natural Product Research, 2020)

Archaeobotanical evidence reveals the human–environment interactions during the 9th–13th centuries at Turpan, Xinjiang on the ancient Silk Road - Yi-Feng Yao; Xia Wang; Wu Guo; Hong-En Jiang; Min Li; David K. Ferguson; Yu-Fei Wang; Cheng-Sen Li (Vegetation History and Archaeobotany, 2020)

MYH7B variants cause hypertrophic cardiomyopathy by activating the CaMK-signaling pathway - Peng Chen; Zongzhe Li; Jiali Nie; Hong Wang; Bo Yu; Zheng Wen; Yang Sun; Xiaolu Shi; Li Jin; Dao-Wen Wang (Science China Life Sciences, 2020)

Correction to: LncRNA NONRATT021972 involved the pathophysiologic processes mediated by P2X7 receptors in stellate ganglia after myocardial ischemic injury - Lifang Zou; Guihua Tu; Wei Xie; Shiyao Wen; Qiuyu Xie; Shuangmei Liu; Guilin Li; Yun Gao; Hong Xu; Shouyu Wang; Yun Xue; Bing Wu; et al. (Purinergic Signalling, 2020)

Identification of pleiotropic genes between risk factors of stroke by multivariate metaCCA analysis - Zun Wang; Jonathan Greenbaum; Chuan Qiu; Kelvin Li; Qian Wang; Si-Yuan Tang; Hong-Wen Deng (Molecular Genetics and Genomics, 2020)

Automated labeling of the airway tree in terms of lobes based on deep learning of bifurcation point detection - Manyang Wang; Renchao Jin; Nanchuan Jiang; Hong Liu; Shan Jiang; Kang Li; XueXin Zhou (Medical & Biological Engineering & Computing, 2020)

Early use of dexamethasone increases Nr4a1 in Kupffer cells ameliorating acute liver failure in mice in a glucocorticoid receptor-dependent manner - Jing-wen Deng; Qin Yang; Xiao-peng Cai; Jia-ming Zhou; Wei-gao E; Yan-dong An; Qiu-xian Zheng; Meng Hong; Yan-li Ren; Jun Guan; Gang Wang; Shu-jing Lai; et al. (Journal of Zhejiang University-SCIENCE B, 2020)

Retraction Note to: Ambient air pollution and adverse birth outcomes: a systematic review and meta-analysis - Le-qian Guo; Yu Chen; Bai-bing Mi; Shao-nong Dang; Dou-dou Zhao; Rong Liu; Hong-li Wang; Hong Yan (Journal of Zhejiang University-SCIENCE B, 2020)

Heat-air-moisture coupled model for radon migration in a porous media - Yu Cui; Shengyang Feng; Puxin Chen; Yongjun Ye; Yurong Wu; Ce Li; Rong Yang; Hong Wang (Environmental Science and Pollution Research, 2020)

Assessment with remotely sensed soil moisture products and ground-based observations over three dense network - Gang Yang; Peng Guo; Xican Li; Hong Wan; Chunhong Meng; Bo Wang (Earth Science Informatics, 2020)

Holocene negative coupling of summer temperature and moisture availability over southeastern arid Central Asia - Jianyong Li; Ninglian Wang; John Dodson; Hong Yan; Xiaojian Zhang; Peter Weiming Jia; Heikki Seppä (Climate Dynamics, 2020)

The effects of soil shrinkage during centrifuge tests on SWCC and soil microstructure measurements - Lincui Li; Xi-An Li; Li Wang; Bo Hong; Jianfeng Shi; Jianqiang Sun (Bulletin of Engineering Geology and the Environment, 2020)

Directional seismic response to the complex topography: A case study of 2013 Lushan Ms 7.0 earthquake - Bo Zhao; Yun-sheng Wang; Li-jun Su; Yong-hong Luo; Jing Zhang (Journal of Mountain Science, 2020)

An improved Gaussian frequency domain sparse inversion method based on compressed sensing - Yang Liu; Jun-Hua Zhang; Yan-Guang Wang; Li-Bin Liu; Hong-Mei Li (Applied Geophysics, 2020)

An overview on marine anti-allergic active substances for alleviating food-induced allergy - Kexin Wang; Siddanakoppalu Narayana Pramod; Tushar Ramesh Pavase; Ishfaq Ahmed; Hang Lin; Liangyu Liu; Shenglan Tian; Hong Lin; Zhenxing Li (Critical Reviews in Food Science and Nutrition, 2020)

Prefrontal Nectin3 Reduction Mediates Adolescent Stress-Induced Deficits of Social Memory, Spatial Working Memory, and Dendritic Structure in Mice - Hong-Li Wang; Ji-Tao Li; Han Wang; Ya-Xin Sun; Rui Liu; Xiao-Dong Wang; Yun-Ai Su; Tian-Mei Si (Neuroscience Bulletin, 2020)
Chronic stress may disrupt the normal neurodevelopmental trajectory of the adolescent brain (especially the prefrontal cortex) and contribute to the pathophysiology of stress-related mental illnesses, but the underlying molecular mechanisms remain unclear. Here, we investigated how synaptic cell adhesion molecules (e.g., nectin3) are involved in the effects of adolescent chronic stress on mouse medial prefrontal cortex (mPFC). Male C57BL/6N mice were subjected to chronic social instability stress from postnatal days 29 to 77. One week later, the mice exposed to chronic stress exhibited impaired social recognition and spatial working memory, simplified dendritic structure, and reduced spine density in the mPFC. Membrane localization of nectin3 was also altered, and was significantly correlated with behavioral performance. Furthermore, knocking down mPFC nectin3 expression by adeno-associated virus in adolescent mice reproduced the stress-induced changes in behavior and mPFC morphology. These results support the hypothesis that nectin3 is a potential mediator of the effects of adolescent chronic stress on prefrontal structural and functional abnormalities.

CSF Brain-Reactive Autoantibodies are Elevated in Patients with Viral Encephalitis - Zhong-Yuan Yu; Jian-Hong Wang; Wei-Wei Li; Ye-Ran Wang; Noralyn B. Mañucat-Tan; Jun Wang; Ju Wang; Gao-Yu Cui; Jie-Xiang Pan; Shui-Xian Zhang; Zu-Juan Liu; Liang Tan; et al. (Neuroscience Bulletin, 2020)

TMEM88 modulates the secretion of inflammatory factors by regulating YAP signaling pathway in alcoholic liver disease - Liang-yun Li; Chen-chen Yang; Su-wen Li; Yu-min Liu; Hao-dong Li; Shuang Hu; Hong Zhou; Jin-liang Wang; Hang Shen; Xiao-ming Meng; Jun Li; Tao Xu (Inflammation Research, 2020)

Brief report of the first cured 2019-nCoV pneumonia patient in West China Hospital - En-Qiang Chen; Li-Chun Wang; Guang-Min Tang; Yao Yang; Min-Jin Wang; Rong Deng; Fang Chen; Meng-Lan Wang; Ya-Chao Tao; Ping Feng; Hong Tang (European Journal of Clinical Microbiology & Infectious Diseases, 2020)

Mixture of Pb, Zn and Cu on root permeability and radial oxygen loss in the mangrove Bruguiera gymnorrhiza - Hao Cheng; You-Shao Wang; Chang-Da Li; Zhi-Hong Ye; Shafi Muhammad; Mei-Lin Wu; Fun-Lin Sun (Ecotoxicology, 2020)

Pseudomonas Saliphila sp. nov., a Bacterium Isolated from Oil-Well Production Water in Qinghai Oilfield of China - Xiao-Juan Zhang; Hong-Can Liu; Yu-Guang Zhou; Xiao-Lei Wu; Yong Nie; Qi-Rui Li; Mei-Zhu Wang; Liang Zhao; Man Cai; Ying-Qian Kang (Current Microbiology, 2020)

Reclassification of Brevibacterium frigoritolerans DSM 8801T as Bacillus frigoritolerans comb. nov. Based on Genome Analysis - Guo-Hong Liu; Bo Liu; Jie-Ping Wang; Jian-Mei Che; Peng-Fei Li (Current Microbiology, 2020)

Assessing drug cue-induced brain response in heroin dependents treated by methadone maintenance and protracted abstinence measures - Xuan Wei; Wei Li; Jiajie Chen; Yongbin Li; Jia Zhu; Hong Shi; Jierong Liu; Jiuhua Xue; Wei Liu; Fan Wang; Yan Liu; Shan Dang; et al. (Brain Imaging and Behavior, 2020)

Impact of grazing on shaping abundance and composition of active methanotrophs and methane oxidation activity in a grassland soil - Yong Li; Yaowei Liu; Hong Pan; Marcela Hernández; Xiongming Guan; Wei Wang; Qichun Zhang; Yu Luo; Hongjie Di; Jianming Xu (Biology and Fertility of Soils, 2020)

Effects of an oasis protective system on aeolian sediment deposition: a case study from Gelintan oasis, southeastern edge of the Tengger Desert, China - Jing Ding; Yun-hu Xie; Xiao-jia Li; Hong-tao Jiang; Ji Wang; Xiao-xi Liu; Xue-qin Wu; Yu-hao Wang; Chun-xing Hai (Journal of Mountain Science, 2020)

New Terpenoids And Lignans From The Twigs Of T ripterygium Hypoglaucum - Hui Zheng; Li Wang; Tao Yang; Dan Liu; Hong-Mei Li; Xuan-Qin Chen; Rong-Tao Li (Natural Product Research, 2020)

Liquid-liquid phase separation in biology: mechanisms, physiological functions and human diseases - Hong Zhang; Xiong Ji; Pilong Li; Cong Liu; Jizhong Lou; Zheng Wang; Wenyu Wen; Yue Xiao; Mingjie Zhang; Xueliang Zhu (Science China Life Sciences, 2020)

A review of progress in coupled ocean-atmosphere model developments for ENSO studies in China - Rong-Hua Zhang; Yongqiang Yu; Zhenya Song; Hong-Li Ren; Youmin Tang; Fangli Qiao; Tongwen Wu; Chuan Gao; Junya Hu; Feng Tian; Yuchao Zhu; Lin Chen; et al. (Journal of Oceanology and Limnology, 2020)

Preparation of aluminum sludge composite gel spheres and adsorption of U(IV) from aqueous solution - Jin-hui Yang; Zeng-jiang Lei; Yang-hong Dai; Yi Luo; Shui-bo Xie; Jing-song Wang; Shu-kui Zhou; Bai Wei; Cong Li; Shi-qing Hu (Environmental Science and Pollution Research, 2020)

High-rate Doppler-aided cycle slip detection and repair method for low-cost single-frequency receivers - Jiaojiao Zhao; Manuel Hernández-Pajares; Zishen Li; Liang Wang; Hong Yuan (GPS Solutions, 2020)

RETRACTED ARTICLE: CiRS-126 inhibits proliferation of ovarian granulosa cells through targeting the miR-21-PDCD4-ROS axis in a polycystic ovarian syndrome model - Jiafeng Lu; Ying Xue; Yuhang Wang; Yang Ding; Qinyan Zou; Min Pan; Longwei Qiao; Chunhua Zhang; Qinyu Ge; Ting Wang; Hong Li (Cell and Tissue Research, 2020)

Enhanced Antitumor Efficacy of Curcumin-Loaded PLGA Nanoparticles Coated with Unique Fungal Hydrophobin - Lu Sun; Hui Xu; Jing-hua Xu; Shao-ning Wang; Jun-wei Wang; Hong-feng Zhang; Wei-ru Jia; Lin-sen Li (AAPS PharmSciTech, 2020)

New 2-(2-phenylethyl)chromone derivatives from agarwood and their inhibitory effects on tumor cells - Yang-Yang Liu; De-Li Chen; Zhang-Xin Yu; Wang Can-Hong; Jian Feng; Yu Meng; Jian-He Wei (Natural Product Research, 2020)

Strengthening the functional research on the interaction between host genes and microbiota - Jian Li; Jun Wang; Hong Wei (Science China Life Sciences, 2020)

Comparison of three ultrasonographic examinations on the synovial membrane vascularity of RA patients - Xiuli Jin; Fengjuan Li; Huanyan Liu; Hong Wang; Jianwen Du (Physical and Engineering Sciences in Medicine, 2020)

SNX-2112, an Hsp90 inhibitor, suppresses cervical cancer cells proliferation, migration, and invasion by inhibiting the Akt/mTOR signaling pathway - Liang-Shun Fu; Hong-Hong Qiu; Min Liu; Liu-Bing Hu; Yan Wang; Peng-Chao Zhang; Man-Mei Li; Yi-Fei Wang; Zhong Liu (Medicinal Chemistry Research, 2020)

Comparison of metabolites in juice, seed and peel of sea buckthorn (Hippophae rhamnoides L. subsp. sinensis) - Chuangyun Wang; Menglin Lei; Hong Zhang; Lijuan Zhao; Zhixin Mu; Meixia Wang; Jianhua Zhang; Yan Deng; Li Zhao (Journal of Plant Biochemistry and Biotechnology, 2020)

RETRACTED ARTICLE: Stabilization of the histone acetyltransferase Tip60 by deubiquitinating enzyme USP7 stimulates the release of pro-inflammatory mediators in acute lung injury - Jing Wang; Hong-Yan Li; Zhen-Bo Su (Journal of Molecular Medicine, 2020)

Single-Cell Clustering Based on Shared Nearest Neighbor and Graph Partitioning - Xiaoshu Zhu; Jie Zhang; Yunpei Xu; Jianxin Wang; Xiaoqing Peng; Hong-Dong Li (Interdisciplinary Sciences: Computational Life Sciences, 2020)

Short-term associations between ambient fine particulate matter pollution and hospital visits for chronic obstructive pulmonary disease in Yinzhou District, China - Cheng-yi Lin; Die Li; Jie-ming Lu; Zhe-bin Yu; Yao Zhu; Peng Shen; Meng-ling Tang; Ming-juan Jin; Hong-bo Lin; Li-ming Shui; Kun Chen; Jian-bing Wang (Environmental Science and Pollution Research, 2020)

The association between prenatal endocrine-disrupting chemical exposure and altered resting-state brain fMRI in teenagers - Jun-Cheng Weng; Chi Ieong Hong; Jeng-Dau Tasi; Chao-Yu Shen; Pen-Hua Su; Shu-Li Wang (Brain Structure and Function, 2020)

Functional connectivity dysfunction of insular subdivisions in cognitive impairment after acute mild traumatic brain injury - Liyan Lu; Fengfang Li; Huiyou Chen; Peng Wang; Hong Zhang; Yu-Chen Chen; Xindao Yin (Brain Imaging and Behavior, 2020)
Purpose This study aimed to investigate the early functional connectivity alterations between insula subdivisions and other cortical regions in patients with acute mild traumatic brain injury (mTBI) and subsequently to explore the relationship between functional connectivity changes of insula subdivisions with other cortical regions and cognitive function. Methods Fifty-three mTBI patients and 37 age-, gender- and education level- matched healthy controls were included in this study. All participants obtained resting state functional magnetic resonance imaging (rs-fMRI) and clinical and neuropsychological evaluations (Montreal cognitive assessment, MoCA) at the acute stage. Functional connectivity alterations of insula subdivisions and correlations with MoCA were further explored by seed-voxel functional connectivity. Results Compared with healthy controls, patients with acute mTBI showed significantly decreased functional connectivity between the L-vAI and the left middle temporal gyrus and right superior frontal gyrus and significantly decreased functional connectivity between the R-vAI and the right middle frontal gyrus and right hippocampus. While significantly decreased functional connectivity were observed between the L-dAI and the right superior frontal gyrus. In addition, significantly increased functional connectivity was observed between the R-PI and the left inferior frontal gyrus. Furthermore, the mTBI group demonstrated positive correlations between performances in orientation and insula and middle temporal gyrus and superior frontal gyrus and middle frontal gyrus functional connectivities. Abstraction scores for mTBI patients positively correlated with functional connectivity between insula and middle frontal gyrus. Conclusions The present study demonstrated functional connectivity dysfunction of insula subdivisions and correlations between these alterations and cognitive performance, which provide a novel insight into the neurophysiological mechanism of cognitive impairment in patients with mTBI at the acute stage.

Neuroanatomical and functional alterations of insula in mild traumatic brain injury patients at the acute stage - Fengfang Li; Liyan Lu; Huiyou Chen; Peng Wang; Hong Zhang; Yu-Chen Chen; Xindao Yin (Brain Imaging and Behavior, 2020)

Epidemiological survey and genetic evolution of H3N2 subtype influenza viruses from stray dogs in Shanghai, China - Hai-Xiao Shen; Fei-Fei Ge; Xin Li; Jian Liu; Hou-Bing Ju; De-Quan Yang; Xian-Chao Yang; Jian Wang; Hong-Jin Zhao (Virus Genes, 2020)

Molecular evolution of GII.P17-GII.17 norovirus associated with sporadic acute gastroenteritis cases during 2013–2018 in Zhoushan Islands, China - Can Chen; Bing Wu; Hui Zhang; Ke-Feng Li; Rong Liu; Hong-Ling Wang; Jian-Bo Yan (Virus Genes, 2020)

Improved production of GTKO/hCD55/hCD59 triple-gene-modified Diannan miniature pigs for xenotransplantation by recloning - Heng Zhao; Yuying Li; Thanapa Wiriyahdamrong; Zaimei Yuan; Yubo Qing; Honghui Li; Kaixiang Xu; Jianxiong Guo; Baoyu Jia; Xuezeng Zhang; Wenmin Cheng; Yanhua Su; et al. (Transgenic Research, 2020)

Trace elements determination and health risk assessment of Tricholoma matsutake from Yunnan Province, China - Hong-xian Chen; Yun Chen; Songfei Li; Wei Zhang; Ying Zhang; Shan Gao; Na Li; Lei Tao; Ying Wang (Journal of Consumer Protection and Food Safety, 2020)

Biological Aerosol Particles in Polluted Regions - Wei Hu; Zihan Wang; Shu Huang; Lujie Ren; Siyao Yue; Ping Li; Qiaorong Xie; Wanyu Zhao; Lianfang Wei; Hong Ren; Libin Wu; Junjun Deng; et al. (Current Pollution Reports, 2020)

Leaf size of woody dicots predicts ecosystem primary productivity - Yaoqi Li; Peter B. Reich; Bernhard Schmid; Nawal Shrestha; Xiao Feng; Tong Lyu; Brian S. Maitner; Xiaoting Xu; Yichao Li; Dongting Zou; Zheng‐Hong Tan; Xiangyan Su; et al. (Ecology Letters, 2020)
A key challenge in ecology is to understand the relationships between organismal traits and ecosystem processes. Here, with a novel dataset of leaf length and width for 10 480 woody dicots in China and 2374 in North America, we show that the variation in community mean leaf size is highly correlated with the variation in climate and ecosystem primary productivity, independent of plant life form. These relationships likely reflect how natural selection modifies leaf size across varying climates in conjunction with how climate influences canopy total leaf area. We find that the leaf size‒primary productivity functions based on the Chinese dataset can predict productivity in North America and vice‐versa. In addition to advancing understanding of the relationship between a climate‐driven trait and ecosystem functioning, our findings suggest that leaf size can also be a promising tool in palaeoecology for scaling from fossil leaves to palaeo‐primary productivity of woody ecosystems.

Trend analysis of climatic variables and their relation to snow cover and water availability in the Central Himalayas: a case study of Langtang Basin, Nepal - Samit Thapa; Bo Li; Donglei Fu; Xiaofei Shi; Bo Tang; Hong Qi; Kun Wang (Theoretical and Applied Climatology, 2020)

NK cell reconstitution following unmanipulated HLA-mismatched/haploidentical transplantation compared with matched sibling transplantation - Li-Juan Hu; Xun-Hong Cao; Xing-Xing Yu; Xue-Fei Liu; Xiao-Su Zhao; Ying-Jun Chang; Xiao-Hui Zhang; Lan-Ping Xu; Yu Wang; Kai-Yan Liu; Xiao-Jun Huang; Xiang-Yu Zhao (Science China Life Sciences, 2020)

Identification of novel functional CpG-SNPs associated with type 2 diabetes and coronary artery disease - Zun Wang; Chuan Qiu; Xu Lin; Lan-Juan Zhao; Yong Liu; Xinrui Wu; Qian Wang; Wei Liu; Kelvin Li; Hong-Wen Deng; Si-Yuan Tang; Hui Shen (Molecular Genetics and Genomics, 2020)

Conversion between porcine naïve-like and primed ESCs and specific pluripotency marker identification - Qiaoyu Chen; Hong Zhang; Haibin Jiang; Manling Zhang; Junzheng Wang; Lihua Zhao; Chenyu Wang; Manling Liu; Rongfeng Li (In Vitro Cellular & Developmental Biology - Animal, 2020)

RNA-Seq revealed that infection with white tip nematodes could downregulate rice photosynthetic genes - Hong-Le Wang; Si-Hua Yang; Mei Lv; Shan-Wen Ding; Jun-Yi Li; Chun-Ling Xu; Hui Xie (Functional & Integrative Genomics, 2020)

Hippocampus-specific regulation of long non-coding RNA and mRNA expression in germ-free mice - Chanjuan Zhou; Xuechen Rao; Haiyang Wang; Benhua Zeng; Yue Yu; Jianjun Chen; Jiaju Zhong; Xunzhong Qi; Li Zeng; Peng Zheng; Wei Hong; Peng Xie (Functional & Integrative Genomics, 2020)

Effects of cuticular wax content and specific leaf area on accumulation and partition of PAHs in different tissues of wheat leaf - Jinfeng Wang; Huanyu Bao; He Zhang; Jiao Li; Huachang Hong; Fuyong Wu (Environmental Science and Pollution Research, 2020)

Integrated assessment of the environmental and economic effects of “coal-to-gas conversion” project in rural areas of northern China - Yue Li; Xueliang Yuan; Yuzhou Tang; Qingsong Wang; Qiao Ma; Ruimin Mu; Junhua Fu; Jinglan Hong; Jon Kellett; Jian Zuo (Environmental Science and Pollution Research, 2020)

Microanisotropy and preferred orientation of grains and aggregates (POGA) of the Malan loess in Yan’an, China: a profile study - Xi’an Li; Bo Hong; Li Wang; Lincui Li; Jianqiang Sun (Bulletin of Engineering Geology and the Environment, 2020)

A new triterpenoid saponin from Pulsatilla cernua predicted by NMR-based mosaic method - An-Dong Wang; Ying Bao; Xia Wang; Mei-Chen Li; Xu-Hong Ren; Jian-Yu Liu; Yong-Nan Xu (Natural Product Research, 2020)

Rapamycin-Preactivated Autophagy Enhances Survival and Differentiation of Mesenchymal Stem Cells After Transplantation into Infarcted Myocardium - Zhi-hua Li; Yong-li Wang; Hai-jie Wang; Jin-hong Wu; Yu-zhen Tan (Stem Cell Reviews and Reports, 2020)
Stem cell transplantation has been limited by poor survival of the engrafted cells in hostile microenvironment of the infarcted myocardium. This study investigated cytoprotective effect of rapamycin-preactivated autophagy on survival of the transplanted mesemchymal stem cells (MSCs). MSCs isolated from rat bone marrow were treated with 50 nmol/L rapamycin for 2 h, and then the cytoprotective effect of rapamycin was examined. After intramyocardial transplantation in rat ischemia/reperfusion models, the survival and differentiation of the rapamycin-pretreated calls were accessed. After treatment with rapamycin, autophagic activities and lysososme production of the cells were increased significantly. In the condition of short-term or long-term hypoxia and serum deprivation, the apoptotic cells in rapamycin-pretreated cells were less, and secretion of HGF, IGF-1, SCF, SDF-1 and VEGF was increased. After transplantation of rapamycin-pretreated cells, repair of the infarcted myocardium and restoration of cardial function were enhanced dramatically. Expression of HGF , IGF-1 , SCF , SDF-1 , VEGF , HIF-1α and IL-10 in the myocardium was upregulated, while expression of IL-1β and TNF-α was downregulated . Tracing of GFP and Sry gene showed that the survival of rapamycin-pretreated cells was increased. Cardiomyogenesis and angiogenesis in the infarcted myocardium were strengthened. Some rapamycin-pretreated cells differentiated into cardiomyocytes or endothelial cells. These results demonstrate that moderate preactivation of autophagy with rapamycin enhances the survival and differentiation of the transplanted MSCs. Rapamycin-primed MSCs can promote repair of the infarcted myocardium and improvement of cardiac function effectively.

Synchrotron Radiation-Based Three-Dimensional Visualization of Angioarchitectural Remodeling in Hippocampus of Epileptic Rats - Pan Gu; Zi-Hao Xu; Yu-Ze Cao; Sheng-Hui Liao; Qian-Fang Deng; Xian-Zhen Yin; Zhuo-Lu Wang; Zhuo-Hui Chen; Xin-Hang Hu; Hui Wang; Li-Zhi Li; Shi-Xin Liu; et al. (Neuroscience Bulletin, 2020)

Development of 19 novel microsatellite markers of lily-of-the-valley (Convallaria, Asparagaceae) from transcriptome sequencing - Qi-Xiang Lu; Jing Gao; Jun-Jie Wu; Xuan Zhou; Xue Wu; Meng-Di Li; Yu-Kun Wei; Rui-Hong Wang; Zhe-Chen Qi; Pan Li (Molecular Biology Reports, 2020)

Abnormal differentiation of regulatory T cells and Th17 cells induced by perinatal bisphenol A exposure in female offspring mice - You-dan Dong; Liang Gao; Feng-juan Wu; Ren Lin; Yuan Meng; Li-hong Jia; Xiao-fei Wang (Molecular & Cellular Toxicology, 2020)

Field survey study on the difference in Cd accumulation capacity of rice and wheat in rice-wheat rotation area - Jiang-li Yang; Long Cang; Xia Wang; Hong-ting Xu; Dong-mei Zhou (Journal of Soils and Sediments, 2020)

Improving prediction of two ENSO types using a multi-model ensemble based on stepwise pattern projection model - Lin Wang; Hong-Li Ren; Jieshun Zhu; Bohua Huang (Climate Dynamics, 2020)
This study focuses on improving prediction of the two types of ENSO by combining multi-model ensemble (MME) with a statistical error correction method that is based on a stepwise pattern projection and applied to all models before doing the MME. We evaluate such a combinational approach using five dynamical model datasets from the North American Multi-model Ensemble (NMME) project for the period of 1982–2010. The prediction skills of the proposed MME show an improvement over most tropical Pacific regions. With regard to the two ENSO types, improvements in prediction skills of the proposed MME are particularly evident for the Niño indices for short lead time. The differences between the Eastern Pacific and Central Pacific ENSO types are more pronounced in the corrected forecasts compared with the uncorrected ones. The zonal center position of sea surface temperature anomalies for the corrected MME is closer to the observed than that for the uncorrected MME. The results indicate that reducing prediction errors of each model member by a good correction method before applying the MME method can provide an effective way for empirically improving forecasts of the two ENSO types.

Coix seed oil prolongs lifespan and enhances stress resistance in Caenorhabditis elegans - Xin-Yan Chen; De-Chun Liao; Ying-Ting Yu; Cong-Min Wei; Ling-Yan Xuan; Shan Li; Hong-Bing Wang (Biogerontology, 2020)

Functional Analysis of Sheep POU2F3 Isoforms - Guang-Wei Ma; Yan-Kai Chu; Hua Yang; Xiao-Hong Yan; En-Guang Rong; Hui Li; Ning Wang (Biochemical Genetics, 2020)
POU domain class 2 transcription factor 3 (POU2F3) plays an important role in keratinocyte proliferation and differentiation. Our previous study identified four sheep POU2F3 transcript variants ( POU2F3-1 , POU2F3-2 , POU2F3-3 , and POU2F3-4 ), encoding three POU2F3 protein isoforms (POU2F3-1, POU2F3-2, and POU2F3-3). However, the functional differences among the three POU2F3 isoforms remain unknown. The objective of this study was to determine the tissue expression pattern of the four POU2F3 transcript variants in sheep and to investigate the functional differences in cell proliferation among the three POU2F3 isoforms. Quantitative RT-PCR analysis showed that the four POU2F3 transcripts were ubiquitously expressed in all tested adult sheep tissues, and POU2F3-1 exhibited higher expression level than the other three POU2F3 transcript variants in skin ( P P P P > 0.05). Dual luciferase reporter assays demonstrated that overexpression of any one of the three POU2F3 isoforms significantly inhibited the promoter activities of keratin 14 ( KRT14 ) and matrix metalloproteinase 19 ( MMP19 ) genes ( P KRT14 and MMP19 genes than POU2F3-1 and POU2F3-2 ( P P > 0.05). These results suggest three sheep POU2F3 isoforms have similar functional effects, but to a different extent.

Litorilituus lipolyticus sp. nov., isolated from intertidal sand of the Yellow Sea in China, and emended description of Colwellia asteriadis - Ang Liu; Yan-Jiao Zhang; Qing-Jie Xue; Hui Wang; Yuan-Yuan Yang; Feng Du; Long-Yu Zhao; Hong-Hua Zhang; Yun-Qing Li; Xiu-Zhen Li (Antonie van Leeuwenhoek, 2020)

Annual ecosystem respiration is resistant to changes in freeze–thaw periods in semi‐arid permafrost - Qi Wang; Wangwang Lv; Bowen Li; Yang Zhou; Lili Jiang; Shilong Piao; Yanfen Wang; Lirong Zhang; Fandong Meng; Peipei Liu; Huan Hong; Yaoming Li; et al. (Global Change Biology, 2020)
Warming in cold regions alters freezing and thawing (F–T) of soil in winter, exposing soil organic carbon to decomposition. Carbon‐rich permafrost is expected to release more CO 2 to the atmosphere through ecosystem respiration (Re) under future climate scenarios. However, the mechanisms of the responses of freeze – thaw periods to climate change and their coupling with Re in situ are poorly understood. Here, using 2 years of continuous data, we test how changes in F–T events relate to annual Re under four warming levels and precipitation addition in a semi‐arid grassland with discontinuous alpine permafrost. Warming shortened the entire F–T period because the frozen period shortened more than the extended freezing period. It decreased total Re during the F–T period mainly due to decrease in mean Re rate. However, warming did not alter annual Re because of reduced soil water content and the small contribution of total Re during the F–T period to annual Re. Although there were no effects of precipitation addition alone or interactions with warming on F–T events, precipitation addition increased total Re during the F–T period and the whole year. This decoupling between changes in soil freeze – thaw events and annual Re could result from their different driving factors. Our results suggest that annual Re could be mainly determined by soil water content rather than by change in freeze – thaw periods induced by warming in semi‐arid alpine permafrost.

ScCas9 recognizes NNG protospacer adjacent motif in genome editing of rice - Yibo Xu; Xiangbing Meng; Junjie Wang; Baoxiang Qin; Kejian Wang; Jiayang Li; Chun Wang; Hong Yu (Science China Life Sciences, 2020)

Non-linear temperature sensitivity of litter component decomposition under warming gradient with precipitation addition on the Tibetan plateau - Wangwang Lv; Lirong Zhang; Haishan Niu; Bowen Li; Qi Wang; Yang Zhou; Yanfen Wang; Lili Jiang; Peipei Liu; Huan Hong; Shugang Jia; Caiyun Luo; et al. (Plant and Soil, 2020)

Dopamine D2 Receptor-Mediated Modulation of Rat Retinal Ganglion Cell Excitability - Ning Yin; Yu-Long Yang; Shuo Cheng; Hong-Ning Wang; Xin Hu; Yanying Miao; Fang Li; Zhongfeng Wang (Neuroscience Bulletin, 2020)

The inhibition of miR-17-5p promotes cortical neuron neurite growth via STAT3/GAP-43 pathway - Liang Zhang; Zhijie Wang; Bo Li; Ziwei Xia; Xin Wang; Yucai Xiu; Zheng Zhang; Chuanjie Chen; Hong Song; Wenhua Li; Mei Yu; Meiling Zhang; et al. (Molecular Biology Reports, 2020)

Inhibition of chemotherapy-related breast tumor EMT by application of redox-sensitive siRNA delivery system CSO-ss-SA/siRNA along with doxorubicin treatment - Xuan Liu; Xue-qing Zhou; Xu-wei Shang; Li Wang; Yi Li; Hong Yuan; Fu-qiang Hu (Journal of Zhejiang University-SCIENCE B, 2020)

Two new species of Encyrtidae (Hymenoptera: Chalcidoidea) from China, parasitoid of Antecerococcus roseus (Green) (Hemiptera: Cerococcidae) on Boehmeria nivea (L.) Gaud - Guo-Hao Zu; Ze-Ning Yang; Xin-Sheng Cao; Yuan-Hong Wang; Cheng-De Li (Phytoparasitica, 2020)

Chemical Stimulation of Renal Tissue Induces Sympathetic Activation and a Pressor Response via the Paraventricular Nucleus in Rats - Chao Ye; Yun Qiu; Feng Zhang; Ai-Dong Chen; Hong Zhou; Jue-Jin Wang; Qi Chen; Yue-Hua Li; Yu-Ming Kang; Guo-Qing Zhu (Neuroscience Bulletin, 2020)

Roles of PTBP1 in alternative splicing, glycolysis, and oncogensis - Wei Zhu; Bo-lun Zhou; Li-juan Rong; Li Ye; Hong-juan Xu; Yao Zhou; Xue-jun Yan; Wei-dong Liu; Bin Zhu; Lei Wang; Xing-jun Jiang; Cai-ping Ren (Journal of Zhejiang University-SCIENCE B, 2020)

Uptake, depuration, bioaccumulation, and selective enrichment of dechlorane plus in common carp (Cyprinus carpio) - Dapeng Wang; Hongliang Jia; Wen-Jun Hong; Xiaohong Xue; Yeqing Sun; Yi-Fan Li; Weijun Guo (Environmental Science and Pollution Research, 2020)

Association of degree of loss aversion and grey matter volume in superior frontal gyrus by voxel-based morphometry - Ce Li; Xue-Qin Wang; Can-Hong Wen; Hai-zhu Tan (Brain Imaging and Behavior, 2020)

Effectiveness analysis of the prediction of regional debris flow susceptibility in post-earthquake and drought site - Ning-sheng Chen; Yong Zhang; Shu-feng Tian; Ming-feng Deng; Tao Wang; Li-hong Liu; Mei Liu; Gui-sheng Hu (Journal of Mountain Science, 2020)

A Review of Research on Tropical Air-Sea Interaction, ENSO Dynamics, and ENSO Prediction in China - Hong-Li Ren; Fei Zheng; Jing-Jia Luo; Run Wang; Minghong Liu; Wenjun Zhang; Tianjun Zhou; Guangqing Zhou (Journal of Meteorological Research, 2020)

Perfluorinated Compounds (PFCs) in Soil of the Pearl River Delta, China: Spatial Distribution, Sources, and Ecological Risk Assessment - Baolin Liu; Hong Zhang; Yong Yu; Liuwei Xie; Juying Li; Xinxuan Wang; Weihua Dong (Archives of Environmental Contamination and Toxicology, 2020)

The false smut pathogen Ustilaginoidea virens requires rice stamens for false smut ball formation - Jing Fan; Jie Liu; Zhi‐You Gong; Pei‐Zhou Xu; Xiao‐Hong Hu; Jin‐Long Wu; Guo‐Bang Li; Juan Yang; Yu‐Qiu Wang; Yu‐Feng Zhou; Shuang‐Cheng Li; Li Wang; et al. (Environmental Microbiology, 2020)
Summary Rice false smut has emerged as a serious grain disease in rice production worldwide. The disease is characterized by the transformation of individual rice florets into false smut balls, which is caused by the fungal pathogen Ustilaginoidea virens . To date, little is known about the host factors required for false smut ball formation by U . virens . In this study, we identified histological determinants for the formation of false smut balls by inoculating U . virens into rice floral mutants defective with respect to individual floral parts. The results showed that U . virens could form mature false smut balls in rice floral mutants with defective pistils, but failed to develop false smut balls in the superwoman mutant lacking stamens, identifying that U . virens requires rice stamens to complete its infection cycle. Comparative transcriptome analysis indicated a list of candidate host genes that may facilitate nutrient acquisition by U . virens from the rice stamens, such as SWEET11 , SWEET14 and SUT5 , and genes involved in the biosynthesis of trehalose and raffinose family sugars. These data pinpoint rice stamens as the key target organ of U . virens infection and provide a valuable starting point for dissecting the molecular mechanism of false smut ball formation.

Constraints on the nature of the basement of the Junggar terrane indicated by the Laba Ordovician continental arc - Chu Wu; Tao Hong; Xing-Wang Xu; Hao Li; Qiang Ke; Hang Li; Lian-Hui Dong (International Geology Review, 2020)

Activity, Abundance, and Community Composition of Anaerobic Ammonia–Oxidizing (Anammox) Bacteria in Sediment Cores of the Pearl River Estuary - Jiapeng Wu; Yiguo Hong; Xiaomei Wen; Yiben Li; Yu Wang; Xiangyang Chang (Estuaries and Coasts, 2020)

One bis-indole alkaloid-voacamine from Voacanga africana Stapf: biological activity evaluation of PTP1B in vitro utilizing enzymology method based on SPRi expriment - Yan-Qiu Wang; Hong-Xiang Li; Xiao-Chun Liu; Jin-Shuang Zhao; Rong-Qiang Liu; Wen-ying Huai; Wei-Jun Ding; Tian-E Zhang; Yun Deng (Natural Product Research, 2019)

Study of Recellularized Human Acellular Arterial Matrix Repairs Porcine Biliary Segmental Defects - Wei Liu; Sheng-Ning Zhang; Zong-Qiang Hu; Shi-Ming Feng; Zhen-Hui Li; Shu-Feng Xiao; Hong-Shu Wang; Li Li (Tissue Engineering and Regenerative Medicine, 2019)

Review of Chinese atmospheric science research over the past 70 years: Atmospheric physics and atmospheric environment - Tijian Wang; Taichang Gao; Hongsheng Zhang; Maofa Ge; Hengchi Lei; Peichang Zhang; Peng Zhang; Chunsong Lu; Chao Liu; Hua Zhang; Qiang Zhang; Hong Liao; et al. (Science China Earth Sciences, 2019)

Plant regeneration in Ixora chinensis from young leaves - TingGe Li; Hong Cai; TongXin Wang; YingGe Fu; WenHan Yang; AnJin Zhao; Zheng Cui; Jian Wang (Plant Cell, Tissue and Organ Culture (PCTOC), 2019)

The High Diversity and Variable Susceptibility of Clinically Relevant Acremonium-Like Species in China - Limin Yao; Hong Wang; Zhe Wan; Ruoyu Li; Jin Yu (Mycopathologia, 2019)

Repellent activities of essential oils rich in sesquiterpenoids from Saussurea amara (L.) DC. and Sigesbeckia pubescens Makino against two stored-product insects - Zhi-Hua Li; Yang Wang; Jian-Sheng Sun; Ji-Gang Li; Ke-Xing Zou; Hong Liu; Gui-Xiang Li; Zhi-Zhong Hu; Li-Zheng Nong; Zhen-Xing Ning; Yan Wu; Shu-Shan Du (Environmental Science and Pollution Research, 2019)

Tropical cyclone damages in Mainland China over 2005–2016: losses analysis and implications - Hong Wang; Min Xu; Anselem Onyejuruwa; Yanjun Wang; Shanshan Wen; Andrew E. Gao; Yubin Li (Environment, Development and Sustainability, 2019)

Experimental study on the physical modeling of loess tunnel-erosion rate - Li Wang; Xi-An Li; Lin-Cui Li; Bo Hong; Jia Liu (Bulletin of Engineering Geology and the Environment, 2019)

Concentration–response modeling of ECG data from early-phase clinical studies to assess QT prolongation risk of contezolid (MRX-I), an oxazolidinone antibacterial agent - Junzhen Wu; Kun Wang; Yuancheng Chen; Hong Yuan; Li Li; Jing Zhang (Journal of Pharmacokinetics and Pharmacodynamics, 2019)

Genome-Wide Identification and Comparative Expression Profile Analysis of the Long-Chain Acyl-CoA synthetase (LACS) Gene Family in Two Different Oil Content Cultivars of Brassica napus - Zhongchun Xiao; Nannan Li; Shufeng Wang; Juanjuan Sun; Liyuan Zhang; Chao Zhang; Hong Yang; Huiyan Zhao; Bo Yang; Lijuan Wei; Hai Du; Cunmin Qu; et al. (Biochemical Genetics, 2019)

Osteological evidence of violence during the formation of the Chinese northern nomadic cultural belt in the Bronze Age - Qun Zhang; Xuezhou Li; Qian Wang; Hui-Yuan Yeh; Hong Zhu; Yanguo Qin; Quanchao Zhang (Archaeological and Anthropological Sciences, 2019)

Effects of micrite microtextures on the elastic and petrophysical properties of carbonate reservoirs - Jian-Guo Pan; Ji-Xin Deng; Chuang Li; Hong-Bin Wang; Hu-Quan Zhang; Jian-Guo Zhao; Gen-Yang Tang (Applied Geophysics, 2019)

Genome-based reclassification of Bacillus plakortidis Borchert et al. 2007 and Bacillus lehensis Ghosh et al. 2007 as a later heterotypic synonym of Bacillus oshimensis Yumoto et al. 2005; Bacillus rhizosphaerae Madhaiyan et al. 2011 as a later heterotypic synonym of Bacillus clausii Nielsen et al. 1995 - Guo-Hong Liu; Manik Prabhu Narsing Rao; Zhou-Yan Dong; Jie-Ping Wang; Jian-Mei Che; Qian-Qian Chen; Cetin Sengonca; Bo Liu; Wen-Jun Li (Antonie van Leeuwenhoek, 2019)

First Report of Theileria Infection of Bactrian Camels (Camelus bactrianus) in Xinjiang, China - Youquan Li; Xuan Li; Junlong Liu; Jinmin Wang; Dan Jia; Aihong Liu; Zonglin He; Guiquan Guan; Zhijie Liu; Guangyuan Liu; Jianxun Luo; Hong Yin (Acta Parasitologica, 2019)