Ketamine induces rapid antidepressant effects via the autophagy-NLRP3 inflammasome pathway - Dongbin Lyu; Fan Wang; Mengke Zhang; Weichieh Yang; Haijing Huang; Qinte Huang; Chenglin Wu; Nuoshi Qian; Meiti Wang; Huanfei Zhang; Sichai Zheng; Jing Chen; et al. (Psychopharmacology, 2022)

Yellow river delta shelter forest dynamic and degradation factors detection in different phenophases - Xiuneng Li; Hong Wang; Shuhong Qin; Yongtao Li; Pengyu Meng; Zhenglin Song; Yicong Wang; Yi Yang (Plant and Soil, 2022)

Transdermal Delivery of Metformin Utilizing Ionic Liquid Technology: Insight Into the Relationship Between Counterion Structures and Properties - Minghuang Hong; Qinglin Wang; Kai Wang; Jinghui Li; Ming-Hui Qi; Guo-Bin Ren (Pharmaceutical Research, 2022)

Phosphorylation of Truncated Tau Promotes Abnormal Native Tau Pathology and Neurodegeneration - Longfei Li; Yanli Jiang; Gang Wu; Yacoubou Abdoul Razak Mahaman; Dan Ke; Qun Wang; Bin Zhang; Jian-Zhi Wang; Hong-Lian Li; Rong Liu; Xiaochuan Wang (Molecular Neurobiology, 2022)

Tetramethylpyrazine protects neural stem cells against sevoflurane-induced toxicity through Akt/GSK-3β pathway - Yan Feng; Kui Wang; Ning Wang; Pengyu Jia; Lei Zhang; Haozheng Yuan; Pan Lu; Yang Lu; Hong Zhang; Rong Li; Yan Zhang; Qianqian Li; et al. (Metabolic Brain Disease, 2022)

Dietary supplementation of two indigenous Bacillus spp on the intestinal morphology, intestinal immune barrier and intestinal microbial diversity of Rhynchocypris lagowskii - Xin-yu Lei; Dong-ming Zhang; Qiu-ju Wang; Gui-qin Wang; Yue-hong Li; Yu-rou Zhang; Men-nan Yu; Qi Yao; Yu-ke Chen; Zhi-xin Guo (Fish Physiology and Biochemistry, 2022)

Cumulative risk assessment of dietary exposure to phthalates in pregnant women in Beijing, China - Danping Shan; Tao Zhang; Ludi Li; Yuqing Sun; Di Wang; Yingzi Li; Zheng Yang; Kanglong Cui; Shaowei Wu; Lei Jin; Bo Hong; Xuejun Shang; et al. (Environmental Science and Pollution Research, 2022)

Correction to: Effects of cryopreservation on the ultrastructure of coral larvae - Luca Cirino; Sujune Tsai; Li-Hsueh Wang; Wen-Chung Hsieh; Cheng-Liang Huang; Zhi-Hong Wen; Chiahsin Lin (Coral Reefs, 2022)

Control, Treatment and Restoration of Contaminated Soils - Hong-Bo Li; Changsheng Qu; Xinyi Cui; Yang Song; Chao Wang; Cheng Gu (Bulletin of Environmental Contamination and Toxicology, 2022)

Differences in small-world networks between methamphetamine and heroin use disorder patients and their relationship with psychiatric symptoms - Yan Liu; Qiang Li; Tianyi Zhang; Lei Wang; Yarong Wang; Jiajie Chen; Jia Zhu; Hong Shi; Wei Wang; Wei Li (Brain Imaging and Behavior, 2022)

Dynamic impact of boulders on different types of concrete dam - Zhu-jun Feng; Xiu-li Wang; Yong-hong Ran (Journal of Mountain Science, 2022)

The full-length genome sequence of a novel amalgavirus in Lilium spp. in China - Yanyan Huo; Xiaoting Li; Jiale Zhou; Shengjie Lin; Jiahao Ding; Huan Liu; Jianglian Yu; Ni Hong; Guoping Wang; Fang Ding (Archives of Virology, 2022)

Paracandidimonas lactea sp. nov., a urea-utilizing bacterium isolated from landfill - Chu Zhang; Qian Pu; Jun-jie Ying; Ying Chen; Cheng-ze Li; Hang-tao Wu; Bin-jie Wang; Yu-han Zhang; Guo-hong Zeng; Ou Li; Xiu-fang Hu; Cong Sun (Archives of Microbiology, 2022)

Screening for SH3TC2 variants in Charcot–Marie–Tooth disease in a cohort of Chinese patients - Bo Sun; Zheng-Qing He; Yan-Ran Li; Jiong-Ming Bai; Hao-Ran Wang; Hong-Fen Wang; Fang Cui; Fei Yang; Xu-Sheng Huang (Acta Neurologica Belgica, 2022)

Residual analysis of QoI fungicides in multiple (six) types of aquatic organisms by UPLC-MS/MS under acutely toxic conditions - Hong Li; Shuai Hu; Fengshou Sun; Qi Sun; Ning Wang; Beixing Li; Nan Zou; Jin Lin; Wei Mu; Xiuyu Pang (Environmental Science and Pollution Research, 2022)

Aculeaquamide A, cytotoxic paraherquamide from the marine fungus Aspergillus aculeatinus WHUF0198 - Jun Wu; Fuqian Wang; Li-Ming He; Si-Yuan Zhou; Shou-Bao Wang; Jia Jia; Kui Hong; You-Sheng Cai (Natural Product Research, 2022)

Wheat genomic study for genetic improvement of traits in China - Jun Xiao; Bao Liu; Yingyin Yao; Zifeng Guo; Haiyan Jia; Lingrang Kong; Aimin Zhang; Wujun Ma; Zhongfu Ni; Shengbao Xu; Fei Lu; Yuannian Jiao; et al. (Science China Life Sciences, 2022)

Anthocyanins identification and transcriptional regulation of anthocyanin biosynthesis in purple Brassica napus - Hong Fu; Hongbo Chao; Xuejie Zhao; Haoyi Wang; Huaixin Li; Weiguo Zhao; Tao Sun; Maoteng Li; Jinyong Huang (Plant Molecular Biology, 2022)

Responses of absorptive root and mycorrhizal colonization of Chinese fir (Cunninghamia lanceolata) to varied environmental conditions - Ying-Chun Liao; Hou-Bao Fan; Liang Li; Xiao-Hua Wei; Hui-Min Wang; Hong-Lang Duan; Wen-Fei Liu; Jia-Li Liu (Plant Ecology, 2022)

Comprehensive profiling of phytochemicals in the fruits of Gardenia jasminoides Ellis and its variety using liquid chromatography coupled with electrospray ionization quadrupole time-of-flight mass spectrometry - Xiao Ye; Xiao-Qian Liu; Dong Zhang; Wei-Hong Feng; Yao-Hua Liang; Chun Li; Zhi-Min Wang (Journal of Natural Medicines, 2022)

Detection of Pyrophosphate and Alkaline Phosphatase Activity Based on PolyT Single Stranded DNA - Copper Nanoclusters - Liu Yao; Xin Li; Hong Li; Zhibin Liao; Chuchu Xie; Ge Ning; Yaohui Wu; Yonghong Wang (Journal of Fluorescence, 2022)

A Rapid Near-Infrared Fluorescent Probe for Cysteine Based on Isophorone and its Application in B16 Cell Imaging - Yan-Ya Wang; Xue-Shuang Yu; Xin-Jie Li; Hong-Bo Liu; Xi Zhu; Ya-Wen Wang; Yu Peng (Journal of Fluorescence, 2022)

Molecular detection of spotted fever group rickettsiae in hedgehogs (Erinaceus amurensis) and hedgehog-attached ticks in Xuyi County, Southeast China - Changqiang Zhu; Lele Ai; Yong Qi; Yunsheng Liu; Hong Li; Fuqiang Ye; Qiuwei Wang; Yizhe Luo; Weilong Tan; Chunmeng Shi (Experimental and Applied Acarology, 2022)
Tick-borne diseases like Rickettsia , Anaplasma and Ehrlichia are widespread infectious zoonoses that threaten the health of both humans and animals worldwide. Ticks and their hosts, such as hedgehogs, can play a crucial role in transmitting tick-borne diseases and the cycle of Rickettsia . To investigate the presence and identity of Rickettsia in hedgehogs and hedgehog-attached ticks in Xuyi County, Southeast China, 114 ticks were collected from 45 hedgehogs captured totally. Via morphological and molecular methods, all these ticks were identified as two species: Haemaphysalis flava (110/114, 96.5%) and Haemaphysalis longicornis (4/114, 3.5%). Rickettsia spp. were genotypically characterized by PCR targeting rrs , gltA , ompA , ompB , and sca4 gene fragments. The prevalence of spotted fever group rickettsiae (SFGR) infection found in hedgehogs and ticks was 17.8% (8/45) and 78.1% (89/114), respectively. Phylogenetic analyses demonstrated that those Rickettsia spp. belong to two species: Rickettsia heilongjiangensis ( R. heilongjiangensis XY-1) and a potential new species, Candidatus Rickettsia xuyiensis XY-2. The present study gave the first evidence of R. heilongjiangensis and Candidatus R. xuyiensis in ticks and hedgehogs of Southeast China. Our findings suggest that hedgehogs might be involved in the natural transmission cycle of Rickettsia species.

Formation and evolution of secondary particulate matter during heavy haze pollution episodes in winter in a severe cold climate region of Northeast China - Ye Hong; Junying Sun; Yanjun Ma; Yangfeng Wang; Xiaolan Li; Yunhai Zhang; Ningwei Liu; Deping Zhou (Environmental Science and Pollution Research, 2022)

Flow characteristics in curved open channel with partial suspended vegetation - Qiao-ling Zhang; He-fang Jing; Chun-guang Li; Wei-hong Wang; Wen-sheng Zhang (Journal of Mountain Science, 2022)

Ensemble forecast of tropical cyclone tracks based on deep neural networks - Chong Wang; Qing Xu; Yongcun Cheng; Yi Pan; Hong Li (Frontiers of Earth Science, 2022)

Examining asymmetric outer-core CAPE in sheared tropical cyclones based on the FNL data set - Yufan Dai; Qingqing Li; Lijuan Wang; Hong Chen (Frontiers of Earth Science, 2022)

Molecular characterization of a novel botourmiavirus with inverted complementary termini from the rice blast fungus Magnaporthe oryzae isolate HF04 - Simnin Shuai; Hong Zheng; Hang Ding; Yao Wang; Jinzhe Li; Fuyu Liu; Fengying Liu; Hongliu An; Shouguo Fang; Songbai Zhang; Qingchao Deng (Archives of Virology, 2022)

Molecular characterization of a new fusarivirus infecting Botryosphaeria dothidea, the causal agent of pear ring rot disease - Ying He; Qi Zou; Shanshan Li; Haodong Zhu; Ni Hong; Guoping Wang; Liping Wang (Archives of Virology, 2022)

Complete genome sequence of a novel virus belonging to the genus Badnavirus in jujube (Ziziphus jujuba Mill.) in China - Baojun Liu; Guoxin Zhang; Danbo Song; Quan Wang; Hong Li; Aixing Gu; Jianyu Bai (Archives of Virology, 2022)

A fast inversion method for ocean parameters based on dispersion curves with a single hydrophone - Xiaoman Li; Biao Wang; Xuejie Bi; Hong Wu (Acta Oceanologica Sinica, 2022)

Oxytocin Receptor in Cerebellar Purkinje Cells Does Not Engage in Autism-Related Behaviors - Li-Ping Shen; Wei Li; Ling-Zhu Pei; Jun Yin; Shu-Tao Xie; Hong-Zhao Li; Chao Yan; Jian-Jun Wang; Qipeng Zhang; Xiao-Yang Zhang; Jing-Ning Zhu (The Cerebellum, 2022)

Ovary transcriptomic analysis reveals regulation effects of dietary fish oil on hormone, lipid, and glucose metabolism in female adult spotted scat (Scatophagus argus) - Tuo Wang; Zhi-Long Liu; Guang-Li Li; Umar Farouk Mustapha; Charles Brighton Ndandala; Hong-Juan Shi; Chun-Hua Zhu; Hua-Pu Chen; Yang Huang; Dong-Neng Jiang (Frontiers in Marine Science, 2022)
In the aquaculture industry, fish oil is widely used as a nutritional supplement to promote the gonadal maturation of broodstocks, while the mechanism of fish oil on ovary development remain unclear. Herein, female adult spotted scat ( Scatophagus argus ) with most ovaries at phase II were fed with diets containing 8% soybean oil (SO) or 8% fish oil (FO) for 60 days. The final average fish body weight was similar between FO and SO groups. The average gonadosomatic index (GSI) of FO group was higher (non-significant) than that of SO group. Finally, the phase IV ovary of the FO and SO groups were 7 and 5 out of 10, respectively. The serum estradiol (E2) level of the FO group was significantly higher than that of the SO group. The proportions of n-3 long-chain polyunsaturated fatty acids (LC-PUFA, such as docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA)) in the ovaries were much higher in the FO group than in the SO group. These results suggest that the maturity level of the FO group is relatively higher than that of the SO group. Transcriptome sequencing was used to detect the ovary gene expression. Comparatively, the ovary transcriptome analysis showed 68 up-regulated and 193 down-regulated genes in the FO group. The expression levels of Jund and Jun necessary for the ovary maturation were up-regulated in the FO group, while Pparγ and Cxcl12 , which could inhibit the ovary development, were down-regulated in the FO group. Cyp3a27 coding the enzyme for degrading the estrogen was significantly down-regulated in the FO group and coincided with the increase of its serum E2. Kif5b which could regulate the glucose metabolism was up-regulated in the FO group. Serum insulin level was also increased in the FO group. Additionally, Aldh3a2 and Plin2 related to lipid metabolism were significantly down-regulated in the FO group. Briefly, dietary fish oil can influence the expression of genes related to steroid hormone, glucose and lipid metabolism. This study will clarify the mechanism of dietary fish oil in promoting ovary development in teleost fish.

Three new sesquiterpenoid alkaloids from the roots of Tripterygium wilfordii and its cytotoxicity - Hong Liang Ye; Yan Liu; Juan Pan; Wei Guan; Yuan Liu; Xiao Mao Li; Si Yi Wang; Adnan Mohammed Algradi; Bing You Yang; Hai Xue Kuang (Natural Product Research, 2022)

Genetic basis underlying tiller angle in rice (Oryza sativa L.) by genome-wide association study - Shaoxing Bai; Jun Hong; Su Su; Zhikang Li; Wensheng Wang; Jianxin Shi; Wanqi Liang; Dabing Zhang (Plant Cell Reports, 2022)

RNF216 Alleviates Radiation-Induced Apoptosis and DNA Damage Through Regulating Ubiquitination-Mediated Degradation of p53 in Glioblastoma - Songwang Xie; Zhen Hong; Yan Li; Junyong Wang; Jian Wang; Shaoquan Li; Yongchang Liu (Molecular Neurobiology, 2022)

MiR-30c-1-3p targets matrix metalloproteinase 9 involved in the rupture of abdominal aortic aneurysms - Lin Yang; Hong-Gang Sui; Meng-Meng Wang; Jia-Yin Li; Xiao-Feng He; Jing-Yuan Li; Xiao-Zeng Wang (Journal of Molecular Medicine, 2022)
Abdominal aortic aneurysm (AAA) can be fatal if ruptured, but there is no predictive biomarker. Our aim was to evaluate the prognostic potential of microRNAs (miRNAs/miRs) in an AAA mouse model and patients with unruptured AAA (URAAA) and ruptured AAA (RAAA). Among the 64 miRNAs differentially expressed in mice with AAA compared to control, miR-30c-1-3p, miR-432-3p, miR-3154, and miR-379-5p had high homology with human miRNAs. MiR-30c-1-3p plasma levels were significantly lower in patients with RAAA than in those with URAAA or control and tended to negatively correlate with the maximum aortic diameter ( r = −0.3153, P = 0.06109). MiR-30c-1-3p targeted matrix metalloproteinase ( MMP)-9 mRNA through the coding region and downregulated its expression in vitro. MMP-9 plasma concentrations were significantly higher in the RAAA group than in the URAAA group ( P < 0.001) and were negatively associated with miR-30c-1-3p levels ( r = −0.3671, P = 0.01981) and positively–with the maximal aortic diameter ( r = 0.6251, P < 0.0001). The optimal cutoff values for MMP-9 expression and the maximal aortic diameter were 461.08 ng/ml and 55.95 mm, with areas under the curve of 0.816 and 0.844, respectively. Our results indicate that plasma levels of miR-30c-1-3p and MMP-9 may be candidate biomarkers of AAA progression. Key messages Downregulation of miR-30c-1-3p expression and upregulation of its potential target MMP-9 are predictors of the devastation of AAA. Downregulation of miR-30c-1-3p expression and its downstream impact on MMP-9 have a potential on predicting the development and rupture of AAA.

Retraction Note: Stabilization of the histone acetyltransferase Tip60 by deubiquitinating enzyme USP7 stimulates the release of pro-inflammatory mediators in acute lung injury - Jing Wang; Hong-Yan Li; Zhen-Bo Su (Journal of Molecular Medicine, 2022)

Design and mechanism of photocatalytic oxidation for the removal of air pollutants: a review - Kanglu Li; Hong Wang; Jianjun Li; Fan Dong (Environmental Chemistry Letters, 2022)

The dynamical-statistical subseasonal prediction of precipitation over China based on the BCC new-generation coupled model - Jie Wu; Hong-Li Ren; Peiqun Zhang; Yan Wang; Ying Liu; Chongbo Zhao; Qiaoping Li (Climate Dynamics, 2022)

PLXDC2 enhances invadopodium formation to promote invasion and metastasis of gastric cancer cells via interacting with PTP1B - Bin Wu; Yan-xia Wang; Jun-jie Wang; Dong-fang Xiang; Meng-si Zhang; Ze-xuan Yan; Wen-ying Wang; Jing-ya Miao; Xi Lan; Jia-jia Liu; Zheng-yan Li; Chuan Li; et al. (Clinical & Experimental Metastasis, 2022)
Plexin-domain containing 2 (PLXDC2) has been reported as an oncoprotein in several human malignancies. However, its expression and roles in gastric cancer remain largely unclear. In this study, we found that PLXDC2 was highly expressed in gastric cancer tissues, and the expression levels were positively correlated with clinicopathological features, but negatively with the patients’ outcome. Cox regression analysis identified PLXDC2 as an independent prognostic indicator for the patients. Knockdown of PLXDC2 markedly suppressed the in vitro invasion and in vivo metastasis of gastric cancer cells, while overexpression of PLXDC2 resulted in opposite effects. Mechanistically, PLXDC2 enhanced the level of phosphorylated Cortactin (p-Cortactin) by physically interacting with protein tyrosine phosphatase 1B (PTP1B), an important dephosphorylase, to prevent its dephosphorylating of p-Cortactin, thereby promoting the formation of invadopodia. Collectively, our results indicate that PLXDC2 contributes to the invasion and metastasis of gastric cancer by inhibiting PTP1B to facilitate the invadopodium formation, and may serve as a potential prognostic biomarker and a therapeutic target for this disease.

History of suicide attempts associated with the thinning right superior temporal gyrus among individuals with schizophrenia - Yi Yin; Jinghui Tong; Junchao Huang; Baopeng Tian; Song Chen; Shuping Tan; Zhiren Wang; Fude Yang; Yongsheng Tong; Fengmei Fan; Peter Kochunov; Neda Jahanshad; et al. (Brain Imaging and Behavior, 2022)

Improving protected area effectiveness through consideration of different human‐pressure baselines - Chun‐Ting Feng; Ming Cao; Fang‐Zheng Liu; Yue Zhou; Jin‐Hong Du; Li‐Bo Zhang; Wen‐Jie Huang; Jian‐Wu Luo; Jun‐Sheng Li; Wei Wang (Conservation Biology, 2022)
Previous assessments of the effectiveness of protected areas (PAs) focused primarily on changes in human pressure over time and did not consider the different human‐pressure baselines of PAs, thereby potentially over‐ or underestimating PA effectiveness. We developed a framework that considers both human‐pressure baseline and change in human pressure over time and assessed the effectiveness of 338 PAs in China from 2010 to 2020. The initial state of human pressure on PAs was taken as the baseline, and changes in human pressure index (HPI) were further analyzed under different baselines. We used the random forest models to identify the management measures that most improved effectiveness in resisting human pressure for the PAs with different baselines. Finally, the relationships between the changes in the HPI and the changes in natural ecosystems in PAs were analyzed with different baselines. Of PAs with low HPI baselines, medium HPI baselines, and high HPI baselines, 76.92% ( n =150), 11.11% ( n =12), and 22.86% ( n =8) , respectively, showed positive effects in resisting human pressure. Overall, ignoring human‐pressure baselines somewhat underestimated the positive effects of PAs, especially for those with low initial human pressure. For PAs with different initial human pressures, different management measures should be taken to improve effectiveness and reduce threats to natural ecosystems. We believe our framework is useful for assessing the effectiveness of PAs globally, and we recommend it be included in the Convention on Biological Diversity Post‐2020 Strategy.

Influence of joint angle on the instability failure characteristics and AE evolution law of underground caverns - Xiao Wang; Na Wu; Hong Li; Yatao Yan (European Journal of Environmental and Civil Engineering, 2022)

Comprehensive analysis using multiple-integrated techniques on the failure mechanism and dynamic process of a long run-out landslide: Jichang landslide case - Yiding Bao; Hong Wang; Lijun Su; Dajiang Geng; Liang Yang; Peng Shao; Yuchao Li; Ni Du (Natural Hazards, 2022)

RIG-I acts as a tumor suppressor in melanoma via regulating the activation of the MKK/p38MAPK signaling pathway - Rui Guo; Shun-Yuan Lu; Jin-Xia Ma; Qian-Lan Wang; Lu Zhang; Ling-Yun Tang; Yan Shen; Chun-Ling Shen; Jin-Jin Wang; Li-Ming Lu; Zhu-Gang Wang; Hong-Xin Zhang (Human Cell, 2022)
Studies have indicated that RIG-I may act as a tumor suppressor and participate in the tumorigenesis of some malignant diseases. However, RIG-I induces distinct cellular responses via different downstream signaling pathways depending on the cell type. To investigate the biological function and underlying molecular mechanism of RIG-I in the tumorigenesis of melanoma, we constructed RIG-I knockout, RIG-I -overexpressing B16-F10 and RIG-I knockdown A375 melanoma cell lines, and analyzed the RIG-I-mediated change in the biological behavior of tumor cells in spontaneous and poly (I:C)-induced RIG-I activation. Cell proliferation, cell cycling, apoptosis and migration were detected by CCK-8 assay, BrdU incorporation assay, Annexin V–PI staining assay and Transwell assay, respectively. In vivo tumorigenicity was evaluated by tumor xenograft growth in nude mice and subsequently by Ki67 staining and TUNEL assays. Furthermore, Western blotting was utilized to explore the underlying mechanism of RIG-I in melanoma cells. Our data showed that RIG-I promotes apoptosis and inhibits proliferation by G1 phase cell cycle arrest in the melanoma cell lines. Mechanistically, RIG-I induced the phosphorylation of p38 MAPK and MAPK kinases MKK3 and MKK4. In conclusion, the current study demonstrated that RIG-I suppressed the development of melanoma by regulating the activity of the MKK/p38 MAPK signaling pathway, which is relevant to research on novel therapeutic targets for this malignant disease.

Ambient air pollutants increase the risk of immunoglobulin E–mediated allergic diseases: a systematic review and meta-analysis - Hua Wang; Xian-Bao Li; Xiu-Jie Chu; Nv-Wei Cao; Hong Wu; Rong-Gui Huang; Bao-Zhu Li; Dong-Qing Ye (Environmental Science and Pollution Research, 2022)

Short-term effect of sulfur dioxide (SO2) change on the risk of tuberculosis outpatient visits in 16 cities of Anhui Province, China: the first multi-city study to explore differences in occupational patients - Xin-Qiang Wang; Jia-Wen Zhao; Kang-Di Zhang; Wen-Jie Yu; Jie Wang; Ying-Qing Li; Xin Cheng; Zhen-Hua Li; Yi-Cheng Mao; Cheng-Yang Hu; Kai Huang; Kun Ding; et al. (Environmental Science and Pollution Research, 2022)

Ancylobacter gelatini sp. nov., isolated from beach sediment of Zhairuo Island, China - Pinmei Wang; Huan Sheng; Kaiwen Zheng; Yi Hong; Sanjit Chandra Debnath; Cen Yan; Kejing Li; Gen Chen; Jinzhong Xu; Fabai Wu; Zhen Guo; Daoqiong Zheng (Archives of Microbiology, 2022)

Pelagic cyanobacterial nitrogen fixation in lakes and ponds of different latitudinal zones - Yan Li; Ye-Xin Yu; Shuo-Nan Ma; Rui-Ting Qiao; Yong-De Cui; Hai-Jun Wang; Hong-Zhu Wang (Aquatic Sciences, 2022)

Air quality assessment and Gray model prediction for the 2022 Winter Olympics in Zhangjiakou, China - Mi Wang; Wenhui Zhao; Lingjun Li; Tong Liu; Lili Wang; Nanchi Shen; Jianming Hong; Wenji Zhao; Zhuowei Hu (Air Quality, Atmosphere & Health, 2022)

Deep-Sea-Derived Fungi as Valuable Producers of Cytotoxic Secondary Metabolites and Their Leads Potential - Guangrong Zhao; Wenli Tang; Jianlong Zhang; Peimin Shi; Youzhi Li; Jiao Wang; Qingqin Shen; Haixia Si; Linlin Jiang; Xin Yu; Hongwei Zhu; Guozhong Chen; et al. (Frontiers in Marine Science, 2022)
Cancer is the leading lethal disease worldwide. Natural products have contributed significantly to the development of approved therapeutic agents. Therefore, research into new bioactive naturally sourced metabolites with lead potential is urgently needed. It is well-known that marine microorganisms are by far one of the most notable and prolific sources of bioactive natural products. Among them, deep-sea-derived fungi are extraordinarily adapted and metabolically active under extreme environmental conditions, which enable them to produce a large number of novel secondary metabolites. Chemical examination of deep-sea-derived fungi has yielded enormous amounts of cytotoxic natural products and potential drug leads. This review summarizes a total of 229 cytotoxic compounds isolated from deep-sea-derived fungi from 2010 to 2021. The emphasis is on the unique chemical diversity of these metabolic products, together with their relevant cytotoxic properties. Among the isolated metabolites, 82 compounds have been found to possess moderate to potent cytotoxic activities. Meanwhile, we also highlight some compounds with potent cytotoxicities (namely “star molecules”) considering their high drug lead potential. This review reveals deep-sea-derived fungi as considerable resources for the development of new drugs and the potential of the newly discovered secondary metabolites as valuable antitumor lead compounds.

Model Simulation of Storm Surge in the Northwestern South China Sea Under the Impact of Sea Level Rise: A Case Study of Super Typhoon Rammasun (2014) - Yongdong Zhou; Zekai Ni; Philip Adam Vetter; Hongzhou Xu; Bo Hong; Hui Wang; Wenshan Li; Sumin Liu (Frontiers in Marine Science, 2022)
Because of global warming, the sea level is expected to continue to rise, possibly having a significant impact on the intensities and spatial distribution characteristics of coastal storm surges. In this study, we took super typhoon Rammasun (2014) as a case study and applied the SCHISM (Semi-implicit Cross-scale Hydroscience Integrated System Model) to simulate storm surge in the northwestern South China Sea under future sea level rise (SLR) scenarios. To improve the accuracy of storm surge hindcast, we used reconstructed wind field to drive the model in which ERA5 reanalysis data were superposed on the wind field calculated from the Holland parametric cyclone model. The results show that the storm surge hindcast was significantly improved by using this reconstructed wind forcing. 2-D and 3-D model hindcast capabilities were compared; the 3-D model reproduced the storm surge better. The regional sea level projections in 2050, 2100, 2200, and 2300 for RCP 4.5 scenarios (provided by the IPCC AR6 dataset) were superposed on the original water depth as the predicted sea levels, then those depths were used in models of storm surge in the study area under a typhoon identical to Rammasun. Model results demonstrate that storm surge peaks in most sea areas decrease nearly linearly with SLR, especially in regions of high surges.

Sporosarcina aquimarina MS4 Regulates the Digestive Enzyme Activities, Body Wall Nutrients, Gut Microbiota, and Metabolites of Apostichopus japonicus - Hong Yi; Qinglu Bai; Ying Li; Honglei Zhan; Yujia Liu; Bingnan Liu; Jihui Wang (Fishes, 2022)
Sporosarcina aquimarina MS4 is a microecological preparation for overwintering Apostichopus japonicus, which has an immune regulation function, but its role in the nutritional regulation of A. japonicus is not clear. This study aimed to describe the effects of S. aquimarina MS4 on the growth, digestion, and body wall nutrition of A. japonicus through feeding experiments and to discuss the potential mechanism of S. aquimarina MS4 regulating gut function through the detection of gut microbiota and metabolites. After 60 days of culture, the growth performance of A. japonicus fed S. aquimarina MS4 (108 cfu/g) significantly improved, and the content of polysaccharide, leucine, phenylalanine, lysine, and docosahexaenoic acid in the body wall significantly increased. Gut microbiota analysis showed that although Proteobacteria, Verrucomicrobia, Firmicutes, and Bacteroidetes were the predominant phyla in all the sea cucumbers, Haloferula and Rubritalea showed significant difference between the group fed with or without S. aquimarina MS4. Metabolomics analysis showed that differential metabolites in the gut were mainly enriched in amino acid metabolism and lipid metabolism. The association analysis of differential metabolites and microbiota showed that the production of some differential metabolites was significantly related to differential microorganisms, which improved the understanding of the function of microorganisms and their roles in the gut of A. japonicus. This study reveals the life activities such as growth and metabolism of A. japonicus, and it provides support for the functional study of the gut microbiome of A. japonicus.

Primary Cutaneous Mucormycosis, Candida Onychomycosis and Endophthalmitis in a Patient with CARD9 Mutation - Lu Zhang; Jianfeng Huang; Yubo Ma; Zhe Wan; Hong Dai; Ruoyu Li; Heng Gu; Xiaowen Wang (Mycopathologia, 2022)

Ligustilide ameliorates cognitive impairment via AMPK/SIRT1 pathway in vascular dementia rat - Dong Peng; Han-Zi Qiao; Hong-Yu Tan; Yi-Xue Wang; Dan Luo; Li-Jun Qiao; Ye-Feng Cai; Shi-Jie Zhang; Qi Wang; Li Guan (Metabolic Brain Disease, 2022)

Integrated metabolism and epigenetic modifications in the macrophages of mice in responses to cold stress - Jingjing Lu; Shoupeng Fu; Jie Dai; Jianwen Hu; Shize Li; Hong Ji; Zhiquan Wang; Jiahong Yu; Jiming Bao; Bin Xu; Jingru Guo; Huanmin Yang (Journal of Zhejiang University-SCIENCE B, 2022)

Prediction of disability-free survival in healthy older people - Johannes Tobias Neumann; Le T. P. Thao; Anne M. Murray; Emily Callander; Prudence R. Carr; Mark R. Nelson; Rory Wolfe; Robyn L. Woods; Christopher M. Reid; Raj C. Shah; Anne B. Newman; Jeff D. Williamson; et al. (GeroScience, 2022)
Prolonging survival in good health is a fundamental societal goal. However, the leading determinants of disability-free survival in healthy older people have not been well established. Data from ASPREE, a bi-national placebo-controlled trial of aspirin with 4.7 years median follow-up, was analysed. At enrolment, participants were healthy and without prior cardiovascular events, dementia or persistent physical disability. Disability-free survival outcome was defined as absence of dementia, persistent disability or death. Selection of potential predictors from amongst 25 biomedical, psychosocial and lifestyle variables including recognized geriatric risk factors, utilizing a machine-learning approach. Separate models were developed for men and women. The selected predictors were evaluated in a multivariable Cox proportional hazards model and validated internally by bootstrapping. We included 19,114 Australian and US participants aged ≥65 years (median 74 years, IQR 71.6–77.7). Common predictors of a worse prognosis in both sexes included higher age, lower Modified Mini-Mental State Examination score, lower gait speed, lower grip strength and abnormal (low or elevated) body mass index. Additional risk factors for men included current smoking, and abnormal eGFR. In women, diabetes and depression were additional predictors. The biased-corrected areas under the receiver operating characteristic curves for the final prognostic models at 5 years were 0.72 for men and 0.75 for women. Final models showed good calibration between the observed and predicted risks. We developed a prediction model in which age, cognitive function and gait speed were the strongest predictors of disability-free survival in healthy older people. Trial registration Clinicaltrials.gov (NCT01038583)

Dietary calcium pyruvate could improve growth performance and reduce excessive lipid deposition in juvenile golden pompano (Trachinotus ovatus) fed a high fat diet - Yiru Shao; Zhiyong Xie; Shusheng Liang; Cuiying Chen; Douglas R. Tocher; Li Lin; Yanhua Huang; Yuanyou Li; Dizhi Xie; Yucong Hong; Shuqi Wang; Cuihong You (Fish Physiology and Biochemistry, 2022)

The Association Between Arsenic Metabolism and Hypertension Among Population with Varying Arsenic Exposure Levels in China - Yinqiao Dong; Miao Zhou; Mingming Zhang; Huanhuan Wang; Yao Chen; Xudan Liu; Shuyi Yang; Hong Lang; Guifan Sun; Xin Li (Exposure and Health, 2022)

Different Surface Appearances Caused by Unbalanced Mn2+ Accumulation in Gallstones Consisting of Cholesterol and CaCO3 Obtained from a Patient After Cholecystectomy - Da-Yong Lu; Jin Zhang; Qiao-Li Liu; Hong-Guang Wang; Meng Cui (Biological Trace Element Research, 2022)

Continuous cropping of alfalfa (Medicago sativa L.) reduces bacterial diversity and simplifies cooccurrence networks in aeolian sandy soil - Yanxia Xu; Junjie Liu; Xuefeng Liu; Hong Li; Zhao Yang; Hongbao Wang; Xinyu Huang; Lan Lan; Yutong An; Lujun Li; Qin Yao; Guanghua Wang (Soil Ecology Letters, 2022)

Intelligent identification method and application of seismic faults based on a balanced classification network - Jing Yang; Ren-Wei Ding; Hui-Yong Wang; Nian-Tian Lin; Li-Hong Zhao; Shuo Zhao; Yu-Jie Zhang (Applied Geophysics, 2022)

An integrated belowground trait‐based understanding of nitrogen‐driven plant diversity loss - Qiuying Tian; Peng Lu; Xiufeng Zhai; Ruifang Zhang; Yao Zheng; Hong Wang; Bao Nie; Wenming Bai; Shuli Niu; Peili Shi; Yuanhe Yang; Kaihui Li; et al. (Global Change Biology, 2022)
Belowground plant traits play important roles in plant diversity loss driven by atmospheric nitrogen (N) deposition. However, the way N enrichment shapes plant microhabitats by patterning belowground traits and finally determines aboveground responses is poorly understood. Here, we investigated the rhizosheath trait of 74 plant species in seven N‐addition simulation experiments across multiple grassland ecosystems in China. We found that rhizosheath formation differed among plant functional groups and contributed to changes in plant community composition induced by N enrichment. Compared with forb species, grass and sedge species exhibited distinct rhizosheaths; moreover, grasses and sedges expanded their rhizosheaths with increasing N‐addition rate which allowed them to colonize belowground habitats. Grasses also shaped a different microenvironment around their roots compared with forbs by affecting the physicochemical, biological, and stress‐avoiding properties of their rhizosphere soil. Rhizosheaths act as a “biofilm‐like shield” by the accumulation of protective compounds, carboxylic anions and polysaccharides, determined by both plants and microorganisms. This enhanced the tolerance of grasses and sedges to stresses induced by N enrichment. Conversely, forbs lacked the protective rhizosheaths which renders their roots sensitive to stresses induced by N enrichment, thus contributing to their disappearance under N‐enriched conditions. This study uncovers the processes by which belowground facilitation and trait matching affect aboveground responses under conditions of N enrichment, which advances our mechanistic understanding of the contribution of competitive exclusion and environmental tolerance to plant diversity loss caused by N deposition.

Fishery Resources, Ecological Environment Carrying Capacity Evaluation and Coupling Coordination Analysis: The Case of the Dachen Islands, East China Sea - Hong Huang; Zuanyi Wang; Yingdong Li; Xu Zhao; Zhenhua Wang; Xiaopeng Cheng (Frontiers in Marine Science, 2022)
Impacts of human activity on the sustainable development of marine fisheries have been greatly concerned, and the carrying capacity with theoretic and practical meanings has become a focused area over the past two decades. More importantly, there are few studies on the fishery resources and environment compound system. In this study, based on the investigation data in Dachen Islands during 2019–2021, we proposed the evaluation method of fishery resources and ecological environment carrying capacity (FRCC & MEECC) and analyzed the coupling coordination degree between the fishery resources and environment. The results showed that (1) the MEECC of Dachen Islands was in the critical overload state and fluctuated significantly among seasons and the winter voyage of 2021 was the worst. (2) The nekton index of Dachen Islands was basically stable, the fish eggs and juvenile index dropped markedly, and the FRCC was also critically overloaded. (3) The fishery resources and marine environment were moderately balanced. Further, the development was relatively synchronized in autumn of 2019 and 2020, while the fishery resources in spring of 2021 lagged behind the marine environment.

Erratum to: MYH7B variants cause hypertrophic cardiomyopathy by activating the CaMK-signaling pathway - Peng Chen; Zongzhe Li; Jiali Nie; Hong Wang; Bo Yu; Zheng Wen; Yang Sun; Xiaolu Shi; Li Jin; Dao-Wen Wang (Science China Life Sciences, 2022)

Identification and functional characterization of safflower cysteine protease 1 as negative regulator in response to low-temperature stress in transgenic Arabidopsis - Hong Yingqi; Yanxi Lv; Jianyi Zhang; Naveed Ahmad; Youbao Li; Nan Wang; Liu Xiuming; Yao Na; Xiaokun Li (Planta, 2022)

PdeHCA2 affects biomass in Populus by regulating plant architecture, the transition from primary to secondary growth, and photosynthesis - Biligen-Gaowa Zhao; Guo Li; Yue-Feng Wang; Zhen Yan; Feng-Qin Dong; Ying-Chang Mei; Wei Zeng; Meng-Zhu Lu; Hong-Bin Li; Qing Chao; Bai-Chen Wang (Planta, 2022)

Synthesis, antibacterial evaluation and in silico study of DOTA-fluoroquinolone derivatives - Weitian Li; Ge Hong; Lina Mao; Zengping Xu; Jiawen Wang; Wenzhi Wang; Tianjun Liu (Medicinal Chemistry Research, 2022)

Identification of PDXDC1 as a novel pleiotropic susceptibility locus shared between lumbar spine bone mineral density and birth weight - Yu-Qian Song; Shi-Di Hu; Xu Lin; Xiang-He Meng; Xiao Wang; Yin-Hua Zhang; Cheng Peng; Rui Gong; Tao Xu; Tong Zhang; Chen-Zhong Li; Dao-Yan Pan; et al. (Journal of Molecular Medicine, 2022)
An increasing number of epidemiological studies have suggested that birth weight (BW) may be a determinant of bone health later in life, although the underlying genetic mechanism remains unclear. Here, we applied a pleiotropic conditional false discovery rate (cFDR) approach to the genome-wide association study (GWAS) summary statistics for lumbar spine bone mineral density (LS BMD) and BW, aiming to identify novel susceptibility variants shared between these two traits. We detected 5 novel potential pleiotropic loci which are located at or near 7 different genes ( NTAN1 , PDXDC1 , CACNA1G , JAG1 , FAT1P1 , CCDC170 , ESR1 ), among which PDXDC1 and FAT1P1 have not previously been linked to these phenotypes. To partially validate the findings, we demonstrated that the expression of PDXDC1 was dramatically reduced in ovariectomized (OVX) mice in comparison with sham-operated (SHAM) mice in both the growth plate and trabecula bone. Furthermore, immunohistochemistry assay with serial sections showed that both osteoclasts and osteoblasts express PDXDC1 , supporting its potential role in bone metabolism. In conclusion, our study provides insights into some shared genetic mechanisms for BMD and BW as well as a novel potential therapeutic target for the prevention of OP in the early stages of the disease development. Key messages We investigated pleiotropy-informed enrichment between LS BMD and BW. We identified genetic variants related to both LS BMD and BW by utilizing a cFDR approach. PDXDC1 is a novel pleiotropic gene which may be related to both LS BMD and BW. Elevated expression of PDXDC1 is related to higher BMD and lower ratio n-6/n-3 PUFA indicating a bone protective effect of PDXDC1.

Poor evidence for host-dependent regular RNA editing in the transcriptome of SARS-CoV-2 - Jinbao Zong; Yanping Zhang; Fenfen Guo; Changyuan Wang; Hong Li; Gaoyang Lin; Wenqing Jiang; Xiaoping Song; Xiufang Zhang; Feng Huang; Min Qi; Xin Zheng (Journal of Applied Genetics, 2022)

MiR-1260b protects against LPS-induced degenerative changes in nucleus pulposus cells through targeting TCF7L2 - Shijie Chen; Guixia Shi; Jin Zeng; Ping Huang Li; Yi Peng; Zhiyu Ding; Hong Qing Cao; Ruping Zheng; Weiguo Wang (Human Cell, 2022)

Transcriptome revealing the dual regulatory mechanism of ethylene on the rhynchophylline and isorhynchophylline in Uncaria rhynchophylla - Xue Li; Xiao-hong Wang; Wei Qiang; Hao-jie Zheng; Li-yang ShangGuan; Ming-sheng Zhang (Journal of Plant Research, 2022)

Influence of density-moisture on air permeability (ka) in compacted loess and correlation between ka and water permeability (ks) - Bo Hong; Xi’an Li; Tao Pang; Li Wang; Jinyang Liu (Arabian Journal of Geosciences, 2022)

Geochronology and geochemistry of Late Triassic intrusions in the Liaodong Peninsula, eastern North China Craton: implications for post-collisional lithospheric thinning - Chen Wang; Zheng-Hong Liu; Gang Li; Xiao-Jie Dong; Shi-Chao Li; Qing-Ying Zhao (International Geology Review, 2022)

A new picrotoxane-type sesquiterpene from Dendrobium nobile Lindl - Pei Wang; Xin Chen; Cai-Hong Cai; Fan-Dong Kong; Sheng-Zhuo Huang; Jing-Zhe Yuan; Xing-Lian Xu; Wen-Li Mei; Hao-Fu Dai (Natural Product Research, 2022)

Two new dammarane-type triterpenoids from the green walnut husks of Juglans mandshurica Maxim - Yuan-Yuan Zhou; Hui-Rui Gao; Hong-Juan Song; Dan-Da Ma; Xiao-Juan Zhang; Yan-Ping Sun; Yan Liu; Xiao-Li Wang; Bing-You Yang; Hai-Xue Kuang (Natural Product Research, 2022)

Spatiotemporal distribution of perfluoroalkyl acid in Chinese eggs - Xinxuan Wang; Hong Zhang; Hui Zhao; Jianying Li (Food Additives & Contaminants Part B-Surveillance, 2022)

Dissection of the practical soybean breeding pipeline by developing ZDX1, a high-throughput functional array - Rujian Sun; Bincheng Sun; Yu Tian; Shanshan Su; Yong Zhang; Wanhai Zhang; Jingshun Wang; Ping Yu; Bingfu Guo; Huihui Li; Yanfei Li; Huawei Gao; et al. (Theoretical and Applied Genetics, 2022)
Key message We developed the ZDX1 high-throughput functional soybean array for high accuracy evaluation and selection of both parents and progeny, which can greatly accelerate soybean breeding. Abstract Microarray technology facilitates rapid, accurate, and economical genotyping. Here, using resequencing data from 2214 representative soybean accessions, we developed the high-throughput functional array ZDX1, containing 158,959 SNPs, covering 90.92% of soybean genes and sites related to important traits. By application of the array, a total of 817 accessions were genotyped, including three subpopulations of candidate parental lines, parental lines and their progeny from practical breeding. The fixed SNPs were identified in progeny, indicating artificial selection during the breeding process. By identifying functional sites of target traits, novel soybean cyst nematode-resistant progeny and maturity-related novel sources were identified by allele combinations, demonstrating that functional sites provide an efficient method for the rapid screening of desirable traits or gene sources. Notably, we found that the breeding index (BI) was a good indicator for progeny selection. Superior progeny were derived from the combination of distantly related parents, with at least one parent having a higher BI. Furthermore, new combinations based on good performance were proposed for further breeding after excluding redundant and closely related parents. Genomic best linear unbiased prediction (GBLUP) analysis was the best analysis method and achieved the highest accuracy in predicting four traits when comparing SNPs in genic regions rather than whole genomic or intergenic SNPs. The prediction accuracy was improved by 32.1% by using progeny to expand the training population. Collectively, a versatile assay demonstrated that the functional ZDX1 array provided efficient information for the design and optimization of a breeding pipeline for accelerated soybean breeding.

Soil phosphorus availability and stoichiometry determine microbial activity and functional diversity of fluvo-aquic soils under long-term fertilization regimes - Wei He; Wenhua Ye; Mingjie Sun; Yaping Li; Manman Chen; Meng Wei; Guoqing Hu; Quangang Yang; Hong Pan; Yanhong Lou; Hui Wang; Yuping Zhuge (Journal of Soils and Sediments, 2022)

Electrochemical enhancement of high-efficiency wet removal of mercury from flue gas - Nai-jiao Xu; Sen Li; Yu-hong Fu; Zhao-yang Wang; Li-juan Feng; Ji Wang (Environmental Science and Pollution Research, 2022)

Short-term effect of ambient air pollutant change on the risk of tuberculosis outpatient visits: a time-series study in Fuyang, China - Xin-Qiang Wang; Ying-Qing Li; Cheng-Yang Hu; Kai Huang; Kun Ding; Xiao-Jing Yang; Xin Cheng; Kang-Di Zhang; Wen-Jie Yu; Jie Wang; Yong-Zhong Zhang; Zhen-tao Ding; et al. (Environmental Science and Pollution Research, 2022)

Association between congenital heart defects and maternal manganese and iron concentrations: a case–control study in China - Meixian Wang; Yan Tian; Ping Yu; Nana Li; Ying Deng; Lu Li; Hong Kang; Dapeng Chen; Hui Wang; Zhen Liu; Juan Liang (Environmental Science and Pollution Research, 2022)
To investigate the correlation between maternal manganese and iron concentrations and the risk of CHD among their infant. A multi-center hospital-based case control study was conducted in China. There were 322 cases and 333 controls have been selected from pregnant women who received prenatal examinations. Correlations between CHDs and maternal manganese and iron concentrations were estimated by conditional logistic regression. Moreover, the interaction between manganese and iron on CHDs was analyzed. Compared with the controls, mothers whose hair manganese concentration was 3.01 μg/g or more were more likely to have a child with CHD than those with a lower concentration. The adjusted OR was 2.68 (95%CI = 1.44–4.99). The results suggested that mothers whose iron content was 52.95 μg/g or more had a significantly higher risk of having a child with CHD ( aOR = 2.87, 95%CI = 1.54–5.37). No interaction between maternal manganese and iron concentrations was observed in the multiplicative or additive model. The concurrently existing high concentration of manganese and iron may bring higher risk of CHD ( OR = 7.02). Women with excessive manganese concentrations have a significantly increased risk of having offspring with CHDs. The high maternal iron status also correlates with CHDs. The concurrently existing high concentration of manganese and iron may bring higher risk of CHD.

Molybdenum background and pollution levels in the Taipu River, China - Feipeng Li; Yue Wang; Lingchen Mao; Hong Tao; Mengmeng Chen (Environmental Chemistry Letters, 2022)

Efficient production of GlcNAc in an aqueous-organic system with a Chitinolyticbacter meiyuanensis SYBC-H1 mutant - Zhi-kui Hao; Jian-song Li; Dan-hua Wang; Fei He; Jing-shi Xue; Liang-hong Yin; Hua-bao Zheng (Biotechnology Letters, 2022)

Functional connectivity alteration of the deprived auditory regions with cognitive networks in deaf and inattentive adolescents - Jianhong Li; Weiwei Men; Jia-Hong Gao; Yang Wang; Xiaoxia Qu; David Chao Dong Zhu; Junfang Xian (Brain Imaging and Behavior, 2022)

Stability of Land-use/Land-cover in National Nature Reserves of Jilin Province, China - Yi Shang; Dongyan Wang; Shuhan Liu; Hong Li (Chinese Geographical Science, 2022)

Numerical simulation of fracture failure characteristics of rock mass with multiple parallel fractures under seepage stress coupling - Peng-fei Wang; Chang-hong Li; Wen-hui Tan (Arabian Journal of Geosciences, 2022)

Four new resorcinol derivatives with neuroprotective activities from Xylaria nigripes - Lan-Qing Li; Jing Li; Hong-Ping Long; Ji-Kai Liu; Xian Wang (Natural Product Research, 2022)

Extensive sequence divergence between the reference genomes of Taraxacum kok-saghyz and Taraxacum mongolicum - Tao Lin; Xia Xu; Huilong Du; Xiuli Fan; Qingwen Chen; Chunyan Hai; Zijian Zhou; Xiao Su; Liquan Kou; Qiang Gao; Lingwei Deng; Jinsheng Jiang; et al. (Science China Life Sciences, 2022)

A truncated CC-NB-ARC gene TaRPP13L1-3D positively regulates powdery mildew resistance in wheat via the RanGAP-WPP complex-mediated nucleocytoplasmic shuttle - Xiangyu Zhang; Guanghao Wang; Xiaojian Qu; Mengmeng Wang; Huan Guo; Lu Zhang; Tingdong Li; Yajuan Wang; Hong Zhang; Wanquan Ji (Planta, 2022)

Mungbean VrCOL1 regulates flowering time under short-day conditions in Arabidopsis - Qianqian Zhang; Jing Dong; Zhanqi Wang; Ying Wang; Chunmei Cai; Hong Zhu; Shuai Li (Plant Cell, Tissue and Organ Culture (PCTOC), 2022)

Assessment of genetic diversity among Chinese high-oleic peanut genotypes using miniature inverted-repeat transposable element markers - Chuan Tang Wang; Guo Sheng Song; Zhi Wei Wang; Hong Ju Li; Hong Wei Han; Xiao Yuan Chi; Xiu Zhen Wang; Xiu Shan Sun (Genetic Resources and Crop Evolution, 2022)

Identification of epigenetic modifications mediating the antagonistic effect of selenium against cadmium-induced breast carcinogenesis - Zhuo-Zhi Liang; Yi-Xin Zhang; Rui-Mei Zhu; Yue-Lin Li; Hong-Mei Jiang; Ruo-Bi Li; Qian-Xin Chen; Qing Wang; Lu-Ying Tang; Ze-Fang Ren (Environmental Science and Pollution Research, 2022)

Is Zooplankton Body Size an Indicator of Water Quality in (Sub)tropical Reservoirs in China? - Li Wang; Jun Chen; Haojie Su; Xufa Ma; Zhixu Wu; Hong Shen; Jia Yu; Jiarui Liu; Yao Wu; Guangyi Ding; Ping Xie (Ecosystems, 2022)

Development and characterization of composition-equivalent formulations to the Sandostatin LAR® by the solvent evaporation method - Avital Beig; Linglin Feng; Jennifer Walker; Rose Ackermann; Justin K. Y. Hong; Tinghui Li; Yan Wang; Steven P. Schwendeman (Drug Delivery and Translational Research, 2022)

Land development suitability analysis for transport planning evaluation and optimization in mountainous ecological region - Gao-ru Zhu; Man Wang; Qi-li Li; Jie Liu; Yan-ni Zhao; Jia-wei Gao; Hong-lei Xu (Journal of Mountain Science, 2022)

Effectiveness of Disinfectants Suitable for Inactivating SARS-CoV-2 at Cold-Chain Temperature - Xiaosong Wu; Yin Chen; Ling Wang; Xiling Guo; Lunbiao Cui; Yiming Shen; Fang Li; Hong Sun; Liubo Zhang; Jin Shen; Yan Xu (Food and Environmental Virology, 2022)

Caldalkalibacillus salinus sp. nov., isolated from a salt lake in Xinjiang, northwest China - Ting-Hao Ouyang; Man Peng; Zhen Zhang; Wei-Xun Chunyu; Li-Ming Wang; En-Min Zhou; Xu-Hong Gao; Shu-Kun Tang (Archives of Microbiology, 2022)

Similar simulation test study on permeability evolution mechanism of fault sliding fracture zone - Peng-fei Wang; Jing Xu; Chang-hong Li (Arabian Journal of Geosciences, 2022)

Can artificial light promote submerged macrophyte growth in summer? - Chao Xu; Hai-Jun Wang; Yan Li; Chi Xu; Qing Yu; Miao Liu; Miao Zhang; Hong-Zhu Wang; David P. Hamilton; Erik Jeppesen (Aquatic Ecology, 2022)

Seismic high-resolution processing method based on spectral simulation and total variation regularization constraints - Guo Xin; Gao Jian-Hu; Yin Xun-De; Yong Xue-Shan; Wang Hong-Qiu; Li Sheng-Jun (Applied Geophysics, 2022)

Morphological and Molecular Characterization of Paragonimus skrjabini Complex from Yunnan, China: A Brief Report - Qiu-Hong Shu; Shu-De Li; Ming Tian; Yong Meng; Shu-Mei-Qi He; Min Zhu; Miao-Miao Wang; Wen-Lin Wang (Acta Parasitologica, 2022)
Purpose To perform environmental sampling and molecular identification of Paragonimus in endemic regions, which may help in minimizing transmission among humans. Methods Mountain crabs from the genus Potamiscus were collected and the encysted metacercariae were extracted and subjected to morphological identification, followed by animal inoculation in Sprague–Dawley (SD) rats. After 112 days of infection, animals were killed and adult worms were extracted from lungs and muscles. The morphology of adult worms was characterized by microscopy and molecular identification was done by polymerase chain reaction, followed by sequencing of cox1 and ITS2 genes. Phylogenetic analysis was done by maximum parsimony method. Results A total of 447 crabs were captured from the streams of Tongchang Town, Jinping County, Yunnan Province, China. The infection rate was found to be 41% (186 out of 447 crabs). The metacercariae of Paragonimus skrjabini was identified by the characteristics round or spherical encysted form measuring 410 to 460 × 400 to 460 µm. After animal infection in SD rats, adults were presumptively confirmed to be P. skrjabini , which was also confirmed by gene amplification and sequence analysis of cox1 and ITS2 regions. Paragonimus skrjabini clustered with previously reported P. skrjabini from Yunnan and Vietnam. The confidence values of their branches were > 95%. Phylogenetic analysis of the ITS2 region revealed two distinct clusters with distinct geographical grouping. Phylogenetic analysis with the combined data sets reiterated the geographical grouping with P. skrjabini from Yunnan clustering with strains from Vietnam. Conclusion Metacercariae of P. skrjabini was discovered in freshwater crabs in Yunnan province, China, and the strains were phylogenetically related to P. skrjabini from Vietnam.

MoOpy2 is essential for fungal development, pathogenicity, and autophagy in Magnaporthe oryzae - Ying‐Ying Cai; Jing‐Yi Wang; Xi‐Yu Wu; Shuang Liang; Xue‐Ming Zhu; Lin Li; Jian‐Ping Lu; Xiao‐Hong Liu; Fu‐Cheng Lin (Environmental Microbiology, 2022)
Summary The development and pathogenicity of the fungus Magnaporthe oryzae , the causal agent of destructive rice blast disease, require it to perceive external environmental signals. Opy2, an overproduction‐induced pheromone‐resistant protein 2, is a crucial protein for sensing external signals in Saccharomyces cerevisiae . However, the biological functions of the homologue of Opy2 in M. oryzae are unclear. In this study, we identified that MoOPY2 is involved in fungal development, pathogenicity, and autophagy in M. oryzae . Deletion of MoOPY2 resulted in pleiotropic defects in hyphal growth, conidiation, germ tube extension, appressorium formation, appressorium turgor generation, and invasive growth, therefore leading to attenuated pathogenicity. Furthermore, MoOpy2 participates in the Osm1 MAPK pathway and the Mps1 MAPK pathway by interacting with the adaptor protein Mst50. The interaction sites of Mst50 and MoOpy2 colocalized with the autophagic marker protein MoAtg8 in the preautophagosomal structure sites (PAS). Notably, the Δ Moopy2 mutant caused cumulative MoAtg8 lipidation and rapid GFP‐MoAtg8 degradation in response to nitrogen starvation, showing that MoOpy2 is involved in the negative regulation of autophagy activity. Taken together, our study revealed that MoOpy2 of M. oryzae plays an essential role in the orchestration of fungal development, appressorium penetration, autophagy and pathogenesis.

White Matter Free Water is a Composite Marker of Cerebral Small Vessel Degeneration - Peiyu Huang; Ruiting Zhang; Yeerfan Jiaerken; Shuyue Wang; Hui Hong; Wenke Yu; Chunfeng Lian; Kaicheng Li; Qingze Zeng; Xiao Luo; Xinfeng Yu; Xiao Wu; et al. (Translational Stroke Research, 2022)

Fine mapping of the tiller inhibition gene TIN4 contributing to ideal plant architecture in common wheat - Zhiqiang Wang; Fangkun Wu; Xudong Chen; Wanlin Zhou; Haoran Shi; Yu Lin; Shuai Hou; Shifan Yu; Hong Zhou; Caixia Li; Yaxi Liu (Theoretical and Applied Genetics, 2022)

Comparative transcriptome analysis revealed the molecular mechanism of the effect of light intensity on the accumulation of rhynchophylline and isorhynchophylline in Uncaria rhynchophylla - Xiao-Hong Wang; Xue Li; Wei Qiang; Xiao-Song Yu; Hao-Jie Zheng; Ming-Sheng Zhang (Physiology and Molecular Biology of Plants, 2022)

Plant-derived lignans as potential antiviral agents: a systematic review - Xin-Ya Xu; Dong-Ying Wang; Yi-Ping Li; Stephen T. Deyrup; Hong-Jie Zhang (Phytochemistry Reviews, 2022)

A Reliable Murine Model of Disseminated Infection Induced by Talaromyces Marneffei - Juan He; Jia-Sheng Li; Hong-Yan Xu; Yi-Qun Kuang; Jun Li; Hong-Bin Li; Zhe Li; Hui-Ling Zhou; Rui-Rui Wang; Yu-Ye Li (Mycopathologia, 2022)

Erratum to: Inhibition of chemotherapy-related breast tumor EMT by application of redox-sensitive siRNA delivery system CSO-ss-SA/siRNA along with doxorubicin treatment - Xuan Liu; Xueqing Zhou; Xuwei Shang; Li Wang; Yi Li; Hong Yuan; Fuqiang Hu (Journal of Zhejiang University-SCIENCE B, 2022)

The influences of α-hemolytic Streptococcus on class switching and complement activation of human tonsillar cells in IgA nephropathy - Muyao Ye; Chang Wang; Ling Li; Qiulan Zhao; Youming Peng; Hong Liu (Immunologic Research, 2022)

LINC01087 indicates a poor prognosis of glioma patients with preoperative MRI - Wangsheng Chen; Fei Wang; Jianhua Zhang; Changqing Li; Lan Hong (Functional & Integrative Genomics, 2022)
Long intergenic non-coding RNA 01,087 (LINC01087) has been concerned as an oncogene in breast cancer, while its mechanism in glioma has been little surveyed. Thus, we searched the prognostic value and functional action of LINC01087 in glioma. Glioma patients after preoperative MRI diagnosis were enrolled, and LINC01087, microRNA (miR)-1277-5p, and alkaline ceramidase 3 (ACER3) levels were tested in glioma cancer tissue. The correlation between LINC01087 expression and the survival of patients were analyzed. LINC01087, miR-1277-5p, and ACER3 levels in U251 cells were altered via transfection, and cell malignant phenotypes were monitored. The relationship between miR-1277-5p and LINC01087 or ACER3 was detected. The LINC01087 and ACER3 expression was in up-regulation and the miR-1277-5p expression was in down-regulation in clinical glioma samples. High expression of LINC01087 was associated with poor prognosis of glioma patients with preoperative MRI. LINC01087 silencing restrained tumor malignancy in glioma cells. Mechanistically, LINC01087 directly interacted with miR-1277-5p. ACER3 was a known target of miR-1277-5p. Moreover, rescue assays reveal that miR-1277-5p overexpression (or ACER3 overexpression) reversed the effects of LINC01087 upregulation (or miR-1277-5p upregulation) on glioma cells. LINC01087 has prognostic significance in glioma and silencing LINC01087 deters glioma development through elevating miR-1277-5p to reduce ACER3 expression.

Effects of cryopreservation on the ultrastructure of coral larvae - Luca Cirino; Sujune Tsai; Li-Hsueh Wang; Wen-Chung Hsieh; Cheng-Liang Huang; Zhi-Hong Wen; Chiahsin Lin (Coral Reefs, 2022)

Aberrant functional and effective connectivity of the frontostriatal network in unilateral acute tinnitus patients with hearing loss - Gang-Ping Zhou; Yu-Chen Chen; Wang-Wei Li; Heng-Le Wei; Yu-Sheng Yu; Qing-Qing Zhou; Xindao Yin; Yue-Jin Tao; Hong Zhang (Brain Imaging and Behavior, 2022)

Delayed body development with reduced triglycerides levels in leptin transgenic pigs - Yubo Qing; Muhammad Ameen Jamal; Dejia Shi; Sumei Zhao; Kaixiang Xu; Deling Jiao; Heng Zhao; Honghui Li; Baoyu Jia; Haizhen Wang; Hong-Ye Zhao; Hong-Jiang Wei (Transgenic Research, 2022)

Secondary metabolites isolated from Agrimonia pilosa Ledeb. - Hong-Rui Li; Yu-Kui Li; Jian Xiao; Cui Yang; Meng-Yuan Jiang; Kai Tian; Wei Wang; Yan-Hong Li; Xiang-Zhong Huang (Natural Product Research, 2022)

SYL3-k increases style length and yield of F1 seeds via enhancement of endogenous GA4 content in Oryza sativa L. pistils - Xiaojing Dang; Yuanqing Zhang; Yulong Li; Siqi Chen; Erbao Liu; Bingjie Fang; Qiangming Liu; Dong She; Zhiyao Dong; Zhilan Fan; Dalu Li; Hui Wang; et al. (Theoretical and Applied Genetics, 2022)
Key message SYL3-k allele increases the outcrossing rate of male sterile line and the yield of hybrid F 1 seeds via enhancement of endogenous GA 4 content in Oryza sativa L. pistils. The change in style length might be an adaptation of rice cultivation from south to north in the northern hemisphere. Abstract The style length (SYL) in rice is one of the major factors influencing the stigma exertion, which affects the outcross rate of male sterile line and the yield of hybrid F 1 seeds. However, the biological mechanisms underlying SYL elongation remain elusive. Here, we report a map-based cloning and characterisation of the allele qSYL3-k . The qSYL3-k allele encodes a MADS-box family transcription factor, and it is expressed in various rice organs. The qSYL3-k allele increases SYL via the elongation of cell length in the style, which is associated with a higher GA 4 content in the pistil. The expression level of OsGA3ox2 in pistils with qSYL3-k alleles is significantly higher than that in pistils with qSYL3-n allele on the same genome background of Nipponbare. The yield of F 1 seeds harvested from plants with 7001S SYL3−k alleles was 16% higher than that from plants with 7001S SYL3−n allele. The sequence data at the qSYL3 locus in 136 accessions showed that alleles containing the haplotypes qSYL3 AA , qSYL3 AG , and qSYL3 GA increased SYL, whereas those containing the haplotype qSYL3 GG decreased it. The frequency of the haplotype qSYL3 GG increases gradually from the south to north in the northern hemisphere. These findings will facilitate improvement in SYL and yield of F 1 seeds henceforward.

Methyl jasmonate treatment, aphid resistance assay, and transcriptomic analysis revealed different herbivore defensive roles between tobacco glandular and non-glandular trichomes - Zhaojun Wang; Yanhua Li; Hongying Zhang; Xiaoxiao Yan; Hong Cui (Plant Cell Reports, 2022)

Nitric Oxide Signaling Pathway in Ventral Tegmental Area is Involved in Regulation of 7,8-Dihydroxyflavone on Alcohol Consumption in Rats - Qing Gao; Tao Yang; Xin-Xin Li; Jun-Wei Xiong; Wei Ma; Yan-Min Xu; Yong Liu; Hong-Yan Zhang; Qi-Yu Wang; Hong-Xuan Wang; Ying Peng; Xiao-Feng Zhu; et al. (Molecular Neurobiology, 2022)

Long noncoding RNA XIST modulates microRNA-135/CREB1 axis to influence osteogenic differentiation of osteoblast-like cells in mice with tibial fracture healing - Ying Zhang; Qiang Yuan; Qiushi Wei; Peifeng Li; Zhikun Zhuang; Jitian Li; Youwen Liu; Leilei Zhang; Zhinan Hong; Wei He; Haibin Wang; Wuyin Li (Human Cell, 2022)

Analysis of equivalent thickness of geological media for lab-scale study of radon exhalation - Changshou Hong; Yini Yang; Hong Wang; Yong Liu; Xiangyang Li; Bo Lei; Ming Lan; Yifan Chen; Xingwang Dai (Environmental Science and Pollution Research, 2022)

Exploratory analysis of the associations between urinary phytoestrogens and thyroid hormones among adolescents and adults in the United States: National Health and Nutrition Examination Survey 2007–2010 - Yun Fan; Hong Qian; Zhuo Wu; Zhi Li; Xiuzhu Li; Yan Zhang; Qiaoqiao Xu; Chuncheng Lu; Xinru Wang (Environmental Science and Pollution Research, 2022)

Microbial controls on heavy metals and nutrients simultaneous release in a seasonally stratified reservoir - Xuecheng Zhang; Shiyuan Ding; Hong Lv; Gaoyang Cui; Mengdi Yang; Yiyao Wang; Tianhao Guan; Xiao-Dong Li (Environmental Science and Pollution Research, 2022)

A satellite-based method for modeling ionospheric slant TEC from GNSS observations: algorithm and validation - Wen Li; Zishen Li; Ningbo Wang; Ang Liu; Kai Zhou; Hong Yuan; Andrzej Krankowski (GPS Solutions, 2022)
Total Electron Content (TEC) modeling is critical for Global Navigation Satellite System (GNSS) users to mitigate ionospheric delay errors. The mapping function is usually used for Vertical TEC ionospheric correction models for slant and vertical TEC conversion. But the mapping function cannot characterize TEC variation in different azimuths between the user and satellites. The ionospheric modeling error resulting from the mapping function tends to be bigger in middle and low latitudes. Therefore, a new algorithm for ionospheric Slant TEC (STEC) modeling with Satellite-based Ionospheric Model (SIM) is proposed in this contribution. Validation tests are carried out with GNSS observation data from the Crustal Movement Observation Network of China during different solar activities and in different seasons. The performance of SIM is compared with that of several commonly-used Global Ionospheric Map (GIM) and Regional Ionospheric Map (RIM) products. The results show that the STEC bias and STD of SIM are within 1.0 TECU and about 2.0 TECU, respectively, and SIM can correct over 90% STEC RMS errors, outperforming the GIM and RIM products. Consequently, the SIM algorithm can be a new option for high-accuracy ionospheric delay correction in regional and local GNSS networks.

LncSNHG3 promotes hepatocellular carcinoma epithelial mesenchymal transition progression through the miR-152-3p/JAK1 pathway - Hong Li; Yu Wu; Runmei Wang; Junmei Guo; Qin Yu; Lihe Zhang; Haiping Zhao; Hao Yang (Genes & Genomics, 2022)

Alteribacter salitolerans sp. nov., isolated from a saline-alkaline soil - Shuang Wang; Lei Sun; Manik Prabhu Narsing Rao; Guo-Hong Liu; Pin-Jiao Jin; Zhou-Yan Dong; Zheng-Han Lian; Xiao-Yu Hao; Ming-Yi Zhang; Wen-Jun Li (Archives of Microbiology, 2022)

Ustusaustin A: a new neuraminidase inhibitory meroterpene from the ascidian-derived endophytic fungus Aspergillus ustus TK-5 - Xin Li; Li Li; Xiao-Ming Li; Hong-Lei Li; Belma Konuklugil; Bin-Gui Wang (Natural Product Research, 2021)

Antioxidant CPA-type indole alkaloids produced from the deep-sea derived fungus Aspergillus sp. SCSIO 41024 - Wei-Hao Chen; Kun-Long Li; Xiu-Ping Lin; Sheng-Rong Liao; Bin Yang; Xue-Feng Zhou; Jun-Jian Wang; Yong-Hong Liu; Jun-Feng Wang (Natural Product Research, 2021)

Discriminative optimization algorithm with global–local feature for LIDAR point cloud registration - Jia Wang; Ping Wang; Biao Li; Ruigang Fu; Siyi Zhao; Hong Zhang (International Journal of Remote Sensing, 2021)

Sigma-1 Receptor Activation Suppresses Microglia M1 Polarization via Regulating Endoplasmic Reticulum–Mitochondria Contact and Mitochondrial Functions in Stress-Induced Hypertension Rats - Kokwin Ooi; Li Hu; Yi Feng; Chenzhi Han; Xiaorong Ren; Xinyi Qian; Haofeng Huang; Sijia Chen; Qi Shi; Hong Lin; Jijiang Wang; Danian Zhu; et al. (Molecular Neurobiology, 2021)

MicroRNA-197-3p mediates damage to human coronary artery endothelial cells via targeting TIMP3 in Kawasaki disease - Chaowu Liu; Deguang Yang; Hong Wang; Shengwei Hu; Xiaofei Xie; Li Zhang; Hongling Jia; Qi Qi (Molecular and Cellular Biochemistry, 2021)

Hydrogen Sulfide Maintains Good Nutrition and Delays Postharvest Senescence in Postharvest Tomato Fruits by Regulating Antioxidative Metabolism - Ting-Ying Zhong; Gai-Fang Yao; Sha-Sha Wang; Ting-Ting Li; Ke-Ke Sun; Jun Tang; Zhong-Qin Huang; Feng Yang; Yan-Hong Li; Xiao-Yan Chen; Lan-Ying Hu; Hua Zhang; et al. (Journal of Plant Growth Regulation, 2021)

Hyper-SUMOylation of SMN induced by SENP2 deficiency decreases its stability and leads to spinal muscular atrophy-like pathology - Yuhong Zhang; Xu Chen; Qiqi Wang; Congcong Du; Wenbin Lu; Hong Yuan; Zhenzhen Zhang; Danqing Li; Xing Ling; Xiang Ren; Yang Zhao; Qi Su; et al. (Journal of Molecular Medicine, 2021)

Deubiquitylation and stabilization of Acf7 by ubiquitin carboxyl-terminal hydrolase 14 (USP14) is critical for NSCLC migration - Guobei Yan; Na Liu; Junhua Wang; Jun Tian; Hongbin Liu; Suping Li; Wenchao Liu; Xiaoliang Li; Kai Li; Hong Wang (Journal of Biosciences, 2021)

Deterioration Characteristics of Pre-flawed Granites Subjected to Freeze-Thaw Cycles and Compression - Chen Qiao; Yu Wang; Yong-jie Tong; He-ping Yang; Chang-hong Li; C. Qiao (Geotechnical and Geological Engineering, 2021)

Identification and expression analysis of cobia (Rachycentron canadum) liver-related miRNAs under hypoxia stress - Jian-sheng Huang; Hong-juan Li; Zhi-xiong Guo; Jian-dong Zhang; Wei-zheng Wang; Zhong-liang Wang; Eric Amenyogbe; Gang Chen (Fish Physiology and Biochemistry, 2021)

DFT studies on pyrolysis mechanisms of tetrabromobisphenol A (TBBPA) - Jinbao Huang; Xin Mu; Xiaosong Luo; Hanxian Meng; Hong Wang; Li Jin; Xinsheng Li; Baosheng Lai (Environmental Science and Pollution Research, 2021)

Astaxanthin Ameliorates Blood Pressure in Salt-Induced Prehypertensive Rats Through ROS/MAPK/NF-κB Pathways in the Hypothalamic Paraventricular Nucleus - Hong-Li Gao; Xiao-Jing Yu; Yan Zhang; Chen-Long Wang; Yi-Ming Lei; Jia-Yue Yu; Dong-Miao Zong; Kai-Li Liu; Dong-Dong Zhang; Ying Li; Hua Tian; Nian-Ping Zhang; et al. (Cardiovascular Toxicology, 2021)

A novel thermophilic β-carotene 15,15′-monooxygenase with broad substrate specificity from the marine bacterium Candidatus Pelagibacter sp. HTCC7211 - Zhangde Long; Yuzhe Zhao; Yun Xue; Min Wang; Jigang Li; Zan Su; Jiansheng Sun; Qibin Liu; Hong Liu; Duobin Mao; Tao Wei (Biotechnology Letters, 2021)

Correction to: 2021 Taxonomic update of phylum Negarnaviricota (Riboviria: Orthornavirae), including the large orders Bunyavirales and Mononegavirales - Jens H. Kuhn; Scott Adkins; Bernard R. Agwanda; Rim Al Kubrusli; Sergey V. Alkhovsky; Gaya K. Amarasinghe; Tatjana Avšič-Županc; María A. Ayllón; Justin Bahl; Anne Balkema-Buschmann; Matthew J. Ballinger; Christopher F. Basler; et al. (Archives of Virology, 2021)

2021 Taxonomic update of phylum Negarnaviricota (Riboviria: Orthornavirae), including the large orders Bunyavirales and Mononegavirales - Jens H. Kuhn; Scott Adkins; Bernard R. Agwanda; Rim Al Kubrusli; Sergey V. Alkhovsky; Gaya K. Amarasinghe; Tatjana Avšič-Županc; María A. Ayllón; Justin Bahl; Anne Balkema-Buschmann; Matthew J. Ballinger; Christopher F. Basler; et al. (Archives of Virology, 2021)

Assessment of probiotic adhesion and inhibitory effect on Escherichia coli and Salmonella adhesion - Ya Wang; Dan Jia; Jia-hui Wang; He-hai Li; Jun-long Liu; Ai-hong Liu; Jin-ming Wang; Gui-quan Guan; Jian-xun Luo; Hong Yin; You-quan Li (Archives of Microbiology, 2021)

lp norm inverse spectral decomposition and its multi-sparsity fusion interpretation - Li Sheng-Jun; Wang Tie-Yi; Gao Jian-Hu; Liu Bing-Yang; Gui Jin-Yong; Wang Hong-Qiu (Applied Geophysics, 2021)

Three-dimensional gravity inversion based on 3D U-Net++ - Wang Yu-Feng; Zhang Yu-Jie; Fu Li-Hua; Li Hong-Wei (Applied Geophysics, 2021)

Stress response mechanisms and description of three novel species Shewanella avicenniae sp. nov., Shewanella sedimentimangrovi sp. nov. and Shewanella yunxiaonensis sp. nov., isolated from mangrove ecosystem - Guo-Hong Liu; Qi Zhang; Manik Prabhu Narsing Rao; Shang Yang; Rong Tang; Huai Shi; Jie-Ping Wang; Guan-Min Huang; Bo Liu; Shun-Gui Zhou; Wen-Jun Li (Antonie van Leeuwenhoek, 2021)

Ultra Low Frequency Wave Produced by Underwater Oscillating Sphere and Its Measurement - Huan Wang; Erzheng Fang; Mingze Wu; Lianjin Hong; Zongru Li (Journal of Marine Science and Engineering, 2021)
When an underwater target moves in viscous fluid, it may cause the periodic movement of the surrounding fluid and generate ultra-low-frequency (ULF) gravity waves. The initial domain of the gravitational surface wave propagating above the moving target is named circular wave. This article studies the ULF circular wave generated by underwater oscillating sphere, which will provide basis for underwater long-range target detection. Firstly, the circular wave caused by the sphere oscillation in a finite deep fluid is studied based on the theory of linear potential flow. Meanwhile, the multipole expansion theory is established to solve the circular wave field. Secondly, the interface wave generated by the target oscillation in a two-layer fluid are numerically analyzed by comparison with the free surface fluctuation of a single-layer fluid. The results show that the amplitude of the internal interface displacement (AIID) is smaller than that of the free surface (AFSD). When the sphere is in the lower layer, the layering effect of the fluid has significant influences on the AFSD. Finally, the results of the pool experiment verified that the wave generated by the oscillating sphere is the surface gravity wave. Furthermore, the change trend of the test result is consistent with the simulation result.

Design, synthesis, brine shrimp lethality and cytotoxicity of some novel 17a-aza-D-homo-androster-17-one derivatives - Dongfeng Hong; Yiming Ma; Siyao Song; Na Li; Junru Wang (Natural Product Research, 2021)

1,4-Dioxane Degradation Performance of Tetrahydrofuran-Grown Arthrobacter sp. WN18 - Peng Wang; Tingchen Cui; Jialu Li; Na Liu; Mei Hong (Water, Air, & Soil Pollution, 2021)

TLR2 Potentiates SR-Marco-Mediated Neuroinflammation by Interacting with the SRCR Domain - Lu Wang; Han-Yu Yang; Cai-Xia Zang; Jun-Mei Shang; Hui Liu; Zi-Hong Zhang; Fang-Yu Yuan; Cheng Ju; Fang-Yuan Li; Xiu-Qi Bao; Dan Zhang (Molecular Neurobiology, 2021)

A drug–biomarker interaction model to predict the key targets of Scutellaria barbata D. Don in adverse-risk acute myeloid leukaemia - Teng Wang; Chun-yi Lyu; Yue-hua Jiang; Xue-yan Dong; Yan Wang; Zong-hong Li; Jin-xin Wang; Rui-rong Xu (Molecular Diversity, 2021)

Shifts in the Abundance and Community Composition of Particle-Associated and Free-Living Nitrospira Across Physicochemical Gradients in the Pearl River Estuary - Yiguo Hong; Jiapeng Wu; Lijing Jiao; Yaohao Hu; Fei Ye; Yu Wang; Yiben Li; Limei Wang; Aimin Long (Estuaries and Coasts, 2021)

Promoting soil microbial-mediated suppressiveness against Fusarium wilt disease by the enrichment of specific fungal taxa via crop rotation - Xianfu Yuan; Beibei Wang; Shan Hong; Wu Xiong; Zongzhuan Shen; Yunze Ruan; Rong Li; Qirong Shen; Francisco Dini-Andreote (Biology and Fertility of Soils, 2021)

Transcriptomic responses of haloalkalitolerant bacterium Egicoccus halophilus EGI 80432T to highly alkaline stress - Dai-Di Chen; Manzoor Ahmad; Yong-Hong Liu; Shuang Wang; Bing-Bing Liu; Shu-Xian Guo; Hong-Chen Jiang; Wen-Sheng Shu; Wen-Jun Li (Extremophiles, 2021)

Evaluation of Rainfall Forecasts by Three Mesoscale Models during the Mei-yu Season of 2008 in Taiwan. Part I: Subjective Comparison - Sahana Paul; Chung-Chieh Wang; Li-Shan Tseng; Dong-In Lee; Jing-Shan Hong; Tzay-Ming Leou (Asia-Pacific Journal of Atmospheric Sciences, 2021)

Mutation of the sixth amino acid of the Rep protein has no effect on porcine circovirus 2b but enhances porcine circovirus 2d replication in vitro - Xiaoyan Wu; Shuo Wang; Changxun Xin; Chen Li; Jianli Shi; Zhe Peng; Chang Liu; Hong Han; Ying Yang; Yao Tian; Jiaxin Li; Shaojian Xu; et al. (Archives of Virology, 2021)

Qaidamihabitans albus gen. nov., sp. nov., a new member of the family Pseudonocardiaceae, and transfer of Prauserella shujinwangii to Qaidamihabitans gen. nov. as Qaidamihabitans shujinwangii comb. nov. - Li-Sha Tian; Gang-Qiang Jiang; Rui Li; Ping Ni; Chuan-En Li; Hong-Yan Zhang; Juan Wang; Xiao-Ping Zhang; Yun Wang; Shu-Kun Tang (Archives of Microbiology, 2021)

A new ergostane derivative from the leaves of Heynea trijuga Roxburgh - Shou-Bai Liu; Zheng Cui; Hui-Qin Chen; Hao Wang; Wen-Hua Dong; Cai-Hong Cai; Wen-Li Mei; Hao-Fu Dai (Natural Product Research, 2021)

Pleosporalins H and I, two new heptaketides from the endophytic fungus Pleosporales sp. F46 by using OSMAC strategy - Hong-Xia Yang; Xiao-Ping Peng; Han Gao; Hui-Min Zhang; Zi-Ru Wang; Gang Li; Hong-Xiang Lou (Natural Product Research, 2021)

Two new phenylpropanoids and a new dihydrostilbenoid from the flower buds of Magnolia biondii pamp and their acetylcholinesterase inhibitory activities - Yan-Gang Cao; Hong-Wei Li; Bing Cao; Jian-Chao Wang; Yan-Li Zhang; Xuan Zhao; Xiao-Ke Zheng; Wei-Sheng Feng (Natural Product Research, 2021)

Peripheral CD4+ T cell signatures in predicting the responses to anti-PD-1/PD-L1 monotherapy for Chinese advanced non-small cell lung cancer - Liliang Xia; Hui Wang; Mingjiao Sun; Yi Yang; Chengcheng Yao; Sheng He; Huangqi Duan; Weimin Xia; Ruiming Sun; Yaxian Yao; Zhiwei Chen; Qiong Zhao; et al. (Science China Life Sciences, 2021)

An atlas of CNV maps in cattle, goat and sheep - Yongzhen Huang; Yunjia Li; Xihong Wang; Jiantao Yu; Yudong Cai; Zhuqing Zheng; Ran Li; Shunjin Zhang; Ningbo Chen; Hojjat Asadollahpour Nanaei; Quratulain Hanif; Qiuming Chen; et al. (Science China Life Sciences, 2021)

Expanding the scope of genome editing with SpG and SpRY variants in rice - Jun Ren; Xiangbing Meng; Fengyue Hu; Qing Liu; Yuexuan Cao; Huiying Li; Changjie Yan; Jiayang Li; Kejian Wang; Hong Yu; Chun Wang (Science China Life Sciences, 2021)

Cloning of Mn-SOD gene and its mRNA expression difference and antioxidant enzyme activities under hypoxia stress of cobia Rachycentron canadum - Jian-Dong Zhang; Hong-Juan Li; Eric Amenyogbe; Wei-Zheng Wang; Jian-Sheng Huang; Gang Chen (Molecular Biology Reports, 2021)

Emerging role of air pollution in chronic kidney disease - Yue Chen; Fan Cao; Jian-Ping Xiao; Xin-Yu Fang; Xue-Rong Wang; Li-Hong Ding; De-Guang Wang; Hai-Feng Pan (Environmental Science and Pollution Research, 2021)

Do foreign direct investment and environmental regulation improve green technology innovation? An empirical analysis based on panel data from the Chinese manufacturing industry - Shi-Chun Xu; Yun-Fan Li; Jing-Nan Zhang; Yan Wang; Xiao-Xue Ma; Hong-Yu Liu; Hai-Ning Wang; Yuan Tao (Environmental Science and Pollution Research, 2021)

Spatial variability pattern of the anaerobic ammonia-oxidizing bacterial community across a salinity gradient from river to ocean - Yiben Li; Yiguo Hong; Jiapeng Wu; Yu Wang; Fei Ye (Ecotoxicology, 2021)

Isolation, Identification and Characterization of Paenibacillus pabuli E1 to Explore Its Aflatoxin B1 Degradation Potential - Gen Li; Xiaoyu Li; Liming Dong; Caixia Li; Panpan Zou; Muhammas Kashif Saleemi; Bilal Murtaza; Bowen Jin; Hong Zhao; Lili Wang; Shuying Li; Huan Yang; et al. (Current Microbiology, 2021)

Inhibition of Maternal c-Src Ameliorates the Male Offspring Hypertension by Suppressing Inflammation and Neurotransmitters in the Paraventricular Nucleus - Qing Su; Xiao-Jing Yu; Qing Yang; Xiao-Min Wang; Wen-Jie Xia; Hong-Bao Li; Kai-Li Liu; Qiu-Yue Yi; Yu-Ming Kang (Cardiovascular Toxicology, 2021)

Food-grade γ-aminobutyric acid production by immobilized glutamate decarboxylase from Lactobacillus plantarum in rice vinegar and monosodium glutamate system - Li-Li Yao; Jia-Ren Cao; Chang-Jiang Lyu; Fang-Fang Fan; Hong-Peng Wang; Hong-Wei Cao; Jun Huang; Le-He Mei (Biotechnology Letters, 2021)

Regional brain network and behavioral alterations in EGR3 gene transfected rat model of schizophrenia - Wenwen Gao; Guangfei Li; Xiaowei Han; Zeyu Song; Shuai Zhao; Feiyi Sun; Hong Ma; Ailing Cui; Yige Wang; Xiuxiu Liu; Yue Chen; Lu Zhang; et al. (Brain Imaging and Behavior, 2021)

Water resources response and prediction under climate change in Tao’er River Basin, Northeast China - Jia-qi Sun; Hong-yan Li; Xiao-jun Wang; Shamsuddin Shahid (Journal of Mountain Science, 2021)

Retraction Note to: CiRS-126 inhibits proliferation of ovarian granulosa cells through targeting the miR-21-PDCD4-ROS axis in a polycystic ovarian syndrome model - Jiafeng Lu; Ying Xue; Yuhang Wang; Yang Ding; Qinyan Zou; Min Pan; Longwei Qiao; Chunhua Zhang; Qinyu Ge; Ting Wang; Hong Li (Cell and Tissue Research, 2021)

Shifting roles of the East China Sea in the phylogeography of red nanmu in East Asia - Kai Jiang; Xin Tong; Yan‐Qian Ding; Zheng‐Wei Wang; Li‐Yuan Miao; Yue‐E Xiao; Wei‐Chang Huang; Yong‐Hong Hu; Xiao‐Yong Chen (Journal of Biogeography, 2021)
Aim The effect of eustasy driven by climatic oscillations on species diversification across the East China Sea (ECS) remains unclear. In this study, Machilus thunbergii (红楠, red nanmu in Chinese) was used as a model species to determine whether the ECS acted as either a “species pump” or “species vacuum” during the Pleistocene. Locations Eastern China, and southern and central Japan. Taxon Lauraceae. Methods Ecological niche modelling was employed to predict the potential distribution of M . thunbergii during the Last Glacial Maximum (LGM) and the last interglacial period. Nuclear microsatellite and chloroplast markers were used to reveal the phylogeographic pattern and infer the population history of 33 M . thunbergii populations. Results The ecological niche models suggested that the ECS provided potentially suitable habitats for M. thunbergii during the LGM. A sharp change in cpDNA haplotypes was found along the eastern China coasts, while microsatellites revealed a clinal pattern for genetic composition from eastern China to central Japan. The divergent lineages formed an admixture on the Zhoushan Archipelago of China and Kyushu Island of Japan. The estimated divergent and admixture times were c . 68 kyr and c . 15 kyr, corresponding to the periods where there were rising sea levels after the MIS4 glaciation and falling sea levels during the LGM, respectively. Main conclusions Machilus thunbergii probably underwent alternating population isolation during interglacial periods and connection during glacial maxima across the ECS, but such periodicity of isolation and connection seems not to have promoted diversification as suggested by the species pump hypothesis. Incipient divergence has been periodically wiped out due to frequent coalescence, rendering the ECS more like a “species vacuum”, particularly for species with relatively long generation lengths.

Taxonomic and phylogenetic β‐diversity of freshwater fish assemblages in relationship to geographical and climatic determinants in North America - Hong Qian; Yong Cao; Cindy Chu; Daijiang Li; Brody Sandel; Xianli Wang; Yi Jin (Global Ecology and Biogeography, 2021)
Aim A full understanding of the origin and maintenance of β‐diversity patterns in a region requires understanding of: (1) the relationships of both taxonomic and phylogenetic β‐diversity (TBD and PBD, respectively) and their respective turnover and nestedness components with geographical and environmental distances; (2) the relative importance of the turnover and nestedness components of β‐diversity; and (3) the relationships between PBD measures representing different evolutionary depths. Here, we investigate all these aspects of β‐diversity simultaneously for freshwater fishes in North America. Location North America north of Mexico (hereafter, North America). Taxon Freshwater fishes. Methods North America was divided into 360 watersheds. Using two sampling approaches (neighbourhood vs. pairwise), we quantified β‐diversity between fish assemblages using various metrics (representing total, turnover and nestedness components of TBD and PBD, and tip‐ vs. basal‐weighted PBD) and related them to geographical and climatic factors using correlation and regression analyses. Results Geographical patterns of total TBD and PBD and their components of turnover and nestedness for freshwater fish assemblages among neighbouring watersheds were highly congruent across North America. Geographical patterns of basal‐weighted PBD were generally opposite to those of tip‐weighted PBD. Metrics of β‐diversity were weakly associated with contemporary climatic variables. TBD and PBD were associated strongly to moderately with geographical distances and moderately with climatic distances. The relationships of metrics of β‐diversity to geographical distances were stronger than those to climatic distances in all cases. Main conclusions Geographical and ecological patterns are highly congruent between taxonomic and tip‐weighted PBD, but those between tip‐ and basal‐weighted PBD are greatly different, suggesting that evolutionary histories have played an important role in shaping β‐diversity. Our study suggests that geographical distance between watersheds is more important than climate similarity in determining β‐diversity between freshwater fish assemblages.

Ambient climate determines the directional trend of community stability under warming and grazing - Peipei Liu; Wangwang Lv; Jianping Sun; Caiyun Luo; Zhenhua Zhang; Xiaoxue Zhu; Xingwu Lin; Jichuang Duan; Guangping Xu; Xiaofeng Chang; Yigang Hu; Qiaoyan Lin; et al. (Global Change Biology, 2021)
Changes in ecological processes over time in ambient treatments are often larger than the responses to manipulative treatments in climate change experiments. However, the impacts of human‐driven environmental changes on the stability of natural grasslands have been typically assessed by comparing differences between manipulative plots and reference plots. Little is known about whether or how ambient climate regulates the effects of manipulative treatments and their underlying mechanisms. We collected two datasets, one a 36‐year long‐term observational dataset from 1983 to 2018, and the other a 10‐year manipulative asymmetric warming and grazing experiment using infrared heaters with moderate grazing from 2006 to 2015 in an alpine meadow on the Tibetan Plateau. The 36‐year observational dataset shows that there was a nonlinear response of community stability to ambient temperature with a positive relationship between them due to an increase in ambient temperature in the first 25 years and then a decrease in ambient temperature thereafter. Warming and grazing decreased community stability with experiment duration through an increase in legume cover and a decrease in species asynchrony, which was due to the decreasing background temperature through time during the 10‐year experiment period. Moreover, the temperature sensitivity of community stability was higher under the ambient treatment than under the manipulative treatments. Therefore, our results suggested that ambient climate may control the directional trend of community stability while manipulative treatments may determine the temperature sensitivity of the response of community stability to climate relative to the ambient treatment. Our study emphasizes the importance of the context dependency of the response of community stability to human‐driven environmental changes.

A review on the removal of heavy metals and metalloids by constructed wetlands: bibliometric, removal pathways, and key factors - Guanlong Yu; Peiyuan Li; Guoliang Wang; Jianwu Wang; Yameng Zhang; Shitao Wang; Kai Yang; Chunyan Du; Hong Chen (World Journal of Microbiology and Biotechnology, 2021)

Methane Concentration in the Heartwood of Living Trees and Estimated Methane Emission on Stems in Upland Forests - Zhi-Ping Wang; Huan-Long Li; Hong-Hui Wu; Shi-Jie Han; Jian-Hui Huang; Xi-Mei Zhang; Xing-Guo Han (Ecosystems, 2021)

Identification of unstable bedrock promontory on steep slope based on UAV photogrammetry - Wei Cui; Xuan-hao Wang; Gui-ke Zhang; Hong-bi Li (Bulletin of Engineering Geology and the Environment, 2021)

Characterization of a transcription factor SlNAC7 gene from Suaeda liaotungensis and its role in stress tolerance - Hong-Fei Wang; Hong-Yan Shan; He Shi; Dan-Dan Wu; Tong-Tong Li; Qiu-Li Li (Journal of Plant Research, 2021)

Study of the mechanical performance of excavation under asymmetrical pressure and reinforcement measures - Wenchao Zhang; Na Wu; Pengjiao Jia; Xiaoqi Zhou; Hong Li; Guoguang Wang (Arabian Journal of Geosciences, 2021)

Modulation of the 5-HT 3 A receptor current by desacylbaldrinal - Li-Xia Wang; Hu-Lan Chen; Hong-Ling Yan; Fei Tang; Hai Zhang; Hong-Xiang Li; Qiang Ye; Cheng Peng; Yu-Zhu Tan (Natural Product Research, 2021)

A 24,482-bp deletion is associated with increased seed weight in Brassica napus L. - Xiaohui Zhang; Qiyang Huang; Pengfei Wang; Feiyang Liu; Mudan Luo; Xiang Li; Zhuanrong Wang; Lili Wan; Guangsheng Yang; Dengfeng Hong (Theoretical and Applied Genetics, 2021)

Alpha-Lipoic Acid Attenuates Cadmium- and Lead-Induced Neurotoxicity by Inhibiting Both Endoplasmic-Reticulum Stress and Activation of Fas/FasL and Mitochondrial Apoptotic Pathways in Rat Cerebral Cortex - Yan Yuan; Shi Wen Zhao; Shuang Quan Wen; Qiao Ping Zhu; Li Wang; Hui Zou; Jian Hong Gu; Xue Zhong Liu; Jian Chun Bian; Zong Ping Liu (Neurotoxicity Research, 2021)

Remelting of a Neoproterozoic arc root: origin of the Pulang and Songnuo porphyry Cu deposits, Southwest China - Dian-Zhong Wang; Ruizhong Hu; Pete Hollings; Xian-Wu Bi; Hong Zhong; Li-Chuan Pan; Cheng-Biao Leng; Ming-Liang Huang; Jing-Jing Zhu (Mineralium Deposita, 2021)

Marine alkaloids as the chemical marker for the prey–predator relationship of the sponge Xestospongia sp. and the nudibranch Jorunna funebris - Qihao Wu; Song-Wei Li; Nicole J. de Voogd; Hong Wang; Li-Gong Yao; Yue-Wei Guo; Xu-Wen Li (Marine Life Science & Technology, 2021)
The dietary relationship study between marine sponge Xestospongia sp. and its nudibranch predators Jorunna funebris based on the discovery of isoquinolinequinones has long been studied. In this study, chemical investigation of the sponge Xestospongia sp. and nudibranch J. funebris from the South China Sea yielded a new marine alkaloid neopetroside C ( 1 ), together with nine known alkaloids ( 2 – 10 ). The chemical structures of all the compounds were elucidated by extensive spectroscopic analysis. Neopetroside C ( 1 ) featured a riboside of nicotinic acid with a rare α - N glycosildic linkage and an acyl residue of ( Z )-2-methylbut-2-enoic acid attached to C-5′. The plausible chemical ecology relationship between sponge Xestospongia sp. and its nudibranch predator J. funebris was proposed based on the biogenetic relationship of the common marine alkaloids. The observation of two structural fragments, ( Z )-2-methylbut-2-enoyloxy and trigonelline groups in both sponge and nudibranch, indicated that nudibranch might uptake chemicals from sponge and then modify and transform them into chemical weapons to defend against predators.

Visual detection of tropomyosin, a major shrimp allergenic protein using gold nanoparticles (AuNPs)-assisted colorimetric aptasensor - Tushar Ramesh Pavase; Hong Lin; Maqsood Ahmed Soomro; Hongwei Zheng; Xiaxia Li; Kexin Wang; Zhenxing Li (Marine Life Science & Technology, 2021)

Evaluation of field resistance to brown stripe disease in novel and major cultivated sugarcane varieties in China - Xiao-Yan Wang; Xiao-Yan Cang; Wei Qin; Hong-Li Shan; Rong-Yue Zhang; Chang-Mi Wang; Wen-Feng Li; Ying-Kun Huang (Journal of Plant Pathology, 2021)

Application of Extension Theory Based on Improved Entropy Weight Method to Rock Slope Analysis in Cold Regions - Chen Qiao; Yu Wang; Chang-hong Li; Bing-qian Yan (Geotechnical and Geological Engineering, 2021)

Construction of high density genetic map and QTL mapping in sorghum × sudangrass - Peng Jin; Lihua Wang; Wenjie Zhao; Jian Zheng; Yi-Hong Wang; Yanlong Liu; Ruirui Meng; Jichao Dai; Lei Zhou; Jieqin Li (Euphytica, 2021)

Safety evaluation and ibuprofen removal via an Alternanthera philoxeroides-based biochar - Yuan-da Du; Xin-qian Zhang; Li Shu; Yu Feng; Cui Lv; Hong-qiang Liu; Fei Xu; Qian Wang; Cong-cong Zhao; Qiang Kong (Environmental Science and Pollution Research, 2021)

Correction to: High-Dose Aluminum Exposure Further Alerts Immune Phenotype in Aplastic Anemia Patients - Yao Zuo; Xiang Lu; Xiaochao Wang; Suren R. Sooranna; Liju Tao; Shiqiang Chen; Hongwen Li; Dan Huang; Guanye Nai; Hong Chen; Chunfeng Pan; Caihong Huang; et al. (Biological Trace Element Research, 2021)
The article High-Dose Aluminum Exposure Further Alerts Immune Phenotype in Aplastic Anemia Patients, written by Yao Zuo, Xiang Lu, Xiaochao Wang, Suren R. Sooranna, Liju Tao, Shiqiang Chen, Hongwen Li, Dan Huang, Guanye Nai, Hong Chen, Chunfeng Pan, Caihong Huang and Yanmin Pang.

Dynamical and Machine Learning Hybrid Seasonal Prediction of Summer Rainfall in China - Jialin Wang; Jing Yang; Hong-Li Ren; Jinxiao Li; Qing Bao; Miaoni Gao (Journal of Meteorological Research, 2021)

A novel lymphatic pattern promotes metastasis of cervical cancer in a hypoxic tumour-associated macrophage-dependent manner - Xiao-Jing Chen; Wen-Fei Wei; Zi-Ci Wang; Nisha Wang; Chu-Hong Guo; Chen-Fei Zhou; Luo-Jiao Liang; Sha Wu; Li Liang; Wei Wang (Angiogenesis, 2021)
Lymphatic remodelling in the hypoxic tumour microenvironment (TME) is critically involved in the metastasis of cervical squamous cell carcinoma (CSCC); however, its underlying mechanisms remain unclear. Here, we uncovered a novel lymphatic pattern in the hypoxic TME, wherein lymphatic vessels (LVs) are encapsulated by tumour-associated macrophages (TAMs) to form an interconnected network. We describe these aggregates as LVEM (LVs encapsulated by TAMs) considering their advantageous metastatic capacity and active involvement in early lymph node metastasis (LNM). Mechanistic investigations revealed that interleukin-10 (IL-10) derived from hypoxic TAMs adjacent to LVs was a prerequisite for lymphangiogenesis and LVEM formation through its induction of Sp1 upregulation in lymphatic endothelial cells (LECs). Interestingly, Sp1 high LECs promoted the transactivation of C–C motif chemokine ligand 1 (CCL1) to facilitate TAM and tumour cell recruitment, thereby forming a positive feedback loop to strengthen the LVEM formation. Knockdown of Sp1 or blockage of CCL1 abrogated LVEM and consequently attenuated LNM. Notably, CSCC non-LNM is largely devoid of hypoxic TAMs and the resultant LVEM, which might explain its metastatic delay. These findings identify a novel and efficient metastasis-promoting lymphatic pattern in the hypoxic TME, which might provide new targets for anti-metastasis therapy and prognostic assessment.

Increasing Temperature Alters the Effects of Extracellular Copper on Thalassiosira Pseudonana Physiology and Transcription - Xinjie Wang; Wang Cao; Hong Du; Wenhua Liu; Ping Li (Journal of Marine Science and Engineering, 2021)
Copper (Cu) is essential for many physiological processes in phytoplankton, including electron-transfer reactions and high-affinity Fe transport systems. However, at high concentrations, Cu can have a toxic effect on phytoplankton. Phytoplankton’s tolerance to certain toxicants in marine ecosystems cannot always be solely attributed to the presence of compounds, as various environmental factors including temperature can also indirectly influence their effects on organisms. In this study, we investigated the effects of different Cu concentrations (0, 19.6, 160, 800, and 8000 nM) on the growth and physiological changes in the centric diatom Thalassiosira pseudonana (CCMP 1335) when simultaneously applied with temperature cultivation of 20 °C and 25 °C. At low (0 nM) and high (8000 nM) Cu concentrations, the growth rate of T. pseudonana was inhibited, though an increase in temperature lessened this inhibition. There were no significant changes in the POC:PON ratio during all of the treatments. However, increasing the temperature significantly decreased the POC: POP, PON: POP and BSi: POP ratios of T. pseudonana. The intracellular Cu content of T. pseudonana varied from 0.13 to 13.28 fg cell−1 in response to increases in ambient Cu concentrations. Lastly, an increase in the Cu concentration decreased the transcriptional expression of CTR (copper transporter), 3Hfcp (photosynthetic protein), and Sit1 (silica shell formation) encoding genes. In conclusion, our results indicated that T. pseudonana can adapt to physiological processes and molecular mechanisms in response to varying Cu concentrations and ambient temperatures.

Three new 5,6,7,8-tetrahydro-2-(2-phenylethyl)chromones and one new dimeric 2-(2-phenylethyl)chromone from agarwood of Aquilaria crassna Pierre ex Lecomte in Laos - Yang-Mei Zhao; Li Yang; Fan-Dong Kong; Wen-Hua Dong; Wei Li; Hui-Qin Chen; Hao Wang; Cai-Hong Cai; Cui-Juan Gai; Wen-Li Mei; Hao-Fu Dai (Natural Product Research, 2021)

A new ent -kaurane diterpene from Isodon henryi - Xue Jiang; Ling-Xia Zhang; Qing-Mei Feng; Hong Wu; Ya-Lin Liu; De-Qin Wang; Li-Ping Dai; Zhi-Min Wang (Natural Product Research, 2021)

Transcriptome analysis of differentially expressed genes in chrysanthemum MET1 RNA interference lines - Dong-ru Kang; Yi Zhu; Shuai-lei Li; Peng-hui Ai; Muhammad Ayoub Khan; Hong-xu Ding; Ying Wang; Zi-cheng Wang (Physiology and Molecular Biology of Plants, 2021)

Capacity of transportation and spread of COVID-19—an ironical fact for developed countries - Li Ma; Zhuo Yu; Yan Jiao; Lin Lin; Wei Zhong; Sara W. Day; Arnold Postlethwaite; Hong Chen; Qiang Li; Heliang Yin; Gang Wang (Environmental Science and Pollution Research, 2021)

A novel de-rusting method with molten salt precleaning and laser cleaning for the recycling of steel parts - Xing Wang; Jianfeng Li; Liming Wang; Xiujie Jia; Minghui Hong; Yuan Ren; Mingliang Ma (Clean Technologies and Environmental Policy, 2021)

Foetidibacter luteolus gen. nov., sp. nov., isolated from the rhizosphere of Salvia miltiorrhiza - Qian Pu; Guo-hong Zeng; Gui-wei Wang; Ling-er Lu; Ang Li; Xu-rui Cheng; Xue-ying Wang; Ou Li; Cong Sun; Xiu-fang Hu (Archives of Microbiology, 2021)