OsPUB41, a U-box E3 ubiquitin ligase, acts as a negative regulator of drought stress response in rice (Oryza Sativa L.) - Dong Hye Seo; Andosung Lee; Seong Gwan Yu; Li Hua Cui; Hye Jo Min; Seung Eun Lee; Na Hyun Cho; Sojung Kim; Hansol Bae; Woo Taek Kim (Plant Molecular Biology, 2021)

Distinct Characteristics of Odor-evoked Calcium and Electrophysiological Signals in Mitral/Tufted Cells in the Mouse Olfactory Bulb - Han Xu; Chi Geng; Xinzhong Hua; Penglai Liu; Jinshan Xu; Anan Li (Neuroscience Bulletin, 2021)
Fiber photometry is a recently-developed method that indirectly measures neural activity by monitoring Ca 2+ signals in genetically-identified neuronal populations. Although fiber photometry is widely used in neuroscience research, the relationship between the recorded Ca 2+ signals and direct electrophysiological measurements of neural activity remains elusive. Here, we simultaneously recorded odor-evoked Ca 2+ and electrophysiological signals [single-unit spikes and local field potentials (LFPs)] from mitral/tufted cells in the olfactory bulb of awake, head-fixed mice. Odors evoked responses in all types of signal but the response characteristics (e.g., type of response and time course) differed. The Ca 2+ signal was correlated most closely with power in the β-band of the LFP. The Ca 2+ signal performed slightly better at odor classification than high-γ oscillations, worse than single-unit spikes, and similarly to β oscillations. These results provide new information to help researchers select an appropriate method for monitoring neural activity under specific conditions.

Deep Learning Model for the Automated Detection and Histopathological Prediction of Meningioma - Hua Zhang; Jiajie Mo; Han Jiang; Zhuyun Li; Wenhan Hu; Chao Zhang; Yao Wang; Xiu Wang; Chang Liu; Baotian Zhao; Jianguo Zhang; Kai Zhang (Neuroinformatics, 2021)

HDAC3 Downregulation Improves Cerebral Ischemic Injury via Regulation of the SDC1-Dependent JAK1/STAT3 Signaling Pathway Through miR-19a Upregulation - Hua Fang; Hua-Feng Li; Ming-Hai He; Miao Yang; Jian-Ping Zhang (Molecular Neurobiology, 2021)

Design, synthesis, and antidepressant/anticonvulsant activities of 3H-benzo[f]chromen chalcone derivatives - Qiu-Wan Tan; Li-Ya He; Zhi-Wen He; Wei-Hua Liu; Shan-Shan Zhang; Lin Lin; Hong-Li Yang; Li-Ping Guan (Medicinal Chemistry Research, 2021)

Layers of interstitial fluid flow along a “slit-shaped” vascular adventitia - Hongyi Li; You Lyu; Xiaoliang Chen; Bei Li; Qi Hua; Fusui Ji; Yajun Yin; Hua Li (Journal of Zhejiang University-SCIENCE B, 2021)

The effect of land use change and soil redistribution on soil organic carbon dynamics in karst graben basin of China - Gaoyong Lan; Chun Liu; Hua Wang; Wei Tang; Xia Wu; Hui Yang; Linling Tu; Bill X. Hu; Jianhua Cao; Qiang Li (Journal of Soils and Sediments, 2021)

Estimation of mountain block recharge on the northern Tianshan Mountains using numerical modeling - Jian-hua Ping; Ya-qiang Zhu; Xue-mei Mei; Wei Leng; Sheng Li; Ji-chang Zhao (Journal of Mountain Science, 2021)

Climate change indirectly enhances sandstorm prevention services by altering ecosystem patterns on the Qinghai-Tibet Plateau - Nan Meng; Yan-zheng Yang; Hua Zheng; Ruo-nan Li (Journal of Mountain Science, 2021)

Individual variation in metabolic rate, locomotion capacity and hypoxia tolerance and their relationships in juveniles of three freshwater fish species - Xu Pang; De-Yong Pu; Dan-Yang Xia; Xiao-Hong Liu; Shi-Hua Ding; Yun Li; Shi-Jian Fu (Journal of Comparative Physiology B, 2021)

An effective interpolation strategy for mitigating the day boundary discontinuities of precise GNSS orbit products - Chuanfeng Song; Hua Chen; Weiping Jiang; Xiangdong An; Qusen Chen; Wudong Li (GPS Solutions, 2021)

Research on meso-scale deformation and failure mechanism of fractured rock mass subject to biaxial compression - Wang Xiaoming; Xiao Yuanjie; Shi Wenbing; Ren Juanjuan; Chang Zhengxing; Li Hua (Arabian Journal of Geosciences, 2021)

Cysteiniphilum marinum sp. nov., isolated from coastal seawater - Hai-Min Luo; Jun-Hui Feng; Liang-Hui Li; Meng-Meng Li; Ru-Qin Liu; Fu Chen; Ying Lin; Wen-Jun Li; Ping-Hua Qu; Min Xiao (Antonie van Leeuwenhoek, 2021)

Marinifaba aquimaris gen. nov., sp. nov., a novel chitin‐degrading gammaproteobacterium in the family Alteromonadaceae isolated from seawater of the Mariana Trench - Xin Sui; Xiao-yan He; Ning-hua Liu; Yan-ru Dang; Qian-qian Cha; Mei-ling Sun; Chun-yang Li; Hui-hui Fu; Xiao-yan Song; Qi-long Qin; Xiu-lan Chen; Yu-zhong Zhang; et al. (Antonie van Leeuwenhoek, 2021)

Correction to: Development of Apremilast Solid Dispersion Using TPGS and PVPVA with Enhanced Solubility and Bioavailability - Liuhong Yang; Penghui Wu; Jinchao Xu; Dihuan Xie; Zhongqing Wang; Qian Wang; Yong Chen; Chuan Hua Li; Jiaxin Zhang; Hangping Chen; Guilan Quan (AAPS PharmSciTech, 2021)

Analyzing 13 Years of Cetacean Strandings: Multiple Stressors to Cetaceans in Taiwanese Waters and Their Implications for Conservation and Future Research - Wen-Ta Li; Lien-Siang Chou; Hue-Ying Chiou; I-Hua Chen; Wei-Cheng Yang (Frontiers in Marine Science, 2021)
This study summarizes the postmortem investigations of 73 cetaceans stranded on the coast of Taiwan between 2001 and 2013, including 51 Delphinidae, 17 Kogiidae, 3 Ziphiidae, 1 Physeteridae, and 1 Balaenopteridae. Of these, eight (11%) were categorized into direct human-related strandings, including fisheries interaction (bycatch), vessel collision and other anthropogenic-related pathology. Gastrointestinal foreign bodies were found in eight individuals (11%). Most of the bacteria isolated from stranded dolphins were zoonotic pathogens including extended-spectrum β-lactamases Escherichia coli , which indicates waste pollution from land. Severe parasite infestation was found in 36 of the cases (49%), which suggests that the immune function could be compromised. Thirty-eight cases (52%) were diagnosed with myocardial patchy fibrosis or dilated cardiomyopathy. The evidence shown here indicates that cetaceans around Taiwanese waters may suffer from multiple stressors. This study provides baseline data for the health assessment of cetacean populations in Taiwan, which may ultimately provide recommendations for future cetacean conservation and research throughout the western Pacific.

Petrogenesis of the early Permian A-type granites in the Halajun region, southwest Tianshan, western Xinjiang, NW China: implications for geodynamics of Tarim large igneous province - Zhao-Jian Zong; Yang-Song Du; Shun-Ting Li; Yi Cao; Jing-Guo Du; Xiao-Hua Deng; Li-Wei Xue (International Geology Review, 2021)

Steroidal glycosides from the underground parts of Hosta ventricosa and their anti-inflammatory activities in mice - Hong-Biao Chu; Nan-Nan Li; Zong-Ping Zhang; Xiao-Yue Hu; Cai-Yun Yu; Lei Hua (Natural Product Research, 2021)

Analysis of unigenes involved in lateral root development in Bupleurum chinense and B. scorzonerifolium - Ma Yu; Hua Chen; Qian Liu; Jing Huang; Kassa Semagn; Dan Liu; Yuchan Li; Bin Yang; Yilian He; Chun Sui; Dabin Hou; Jianhe Wei (Planta, 2021)

Characterization of the pectin methylesterase inhibitor gene family in Rosaceae and role of PbrPMEI23/39/41 in methylesterified pectin distribution in pear pollen tube - Xiaoxuan Zhu; Chao Tang; Qionghou Li; Xin Qiao; Xian Li; Yilin Cai; Peng Wang; Yangyang Sun; Hua Zhang; Shaoling Zhang; Juyou Wu (Planta, 2021)

Genome-Wide Identification and Expression Analysis of Heavy Metal Stress–Responsive Metallothionein Family Genes in Nicotiana tabacum - Qin Yu; Linshen He; Chunsong Huo; Xiaohan Jiang; Hua Chen; Run Wang; Minzhi Tang; Ling Dong; Ji Chen; Yonghao Li; Shunqin Zhu; Wanhong Liu (Plant Molecular Biology Reporter, 2021)

Somatic embryogenesis of masson pine (Pinus massoniana): initiation, maturation and genetic stability analysis at SSR loci - Xin-Rui Xia; Fan Yang; Xin Ke; You-Mei Chen; Jian-Ren Ye; Li-Hua Zhu (Plant Cell, Tissue and Organ Culture (PCTOC), 2021)

Genetic Architecture of Childhood Kidney and Urological Diseases in China - Ye Fang; Hua Shi; Tianchao Xiang; Jiaojiao Liu; Jialu Liu; Xiaoshan Tang; Xiaoyan Fang; Jing Chen; Yihui Zhai; Qian Shen; Guomin Li; Li Sun; et al. (Phenomics, 2021)
Kidney disease is manifested in a wide variety of phenotypes, many of which have an important hereditary component. To delineate the genotypic and phenotypic spectrum of pediatric nephropathy, a multicenter registration system is being implemented based on the Chinese Children Genetic Kidney Disease Database (CCGKDD). In this study, all the patients with kidney and urological diseases were recruited from 2014 to 2020. Genetic analysis was conducted using exome sequencing for families with multiple affected individuals with nephropathy or clinical suspicion of a genetic kidney disease owing to early-onset or extrarenal features. The genetic diagnosis was confirmed in 883 of 2256 (39.1%) patients from 23 provinces in China. Phenotypic profiles showed that the primary diagnosis included steroid-resistant nephrotic syndrome (SRNS, 23.5%), glomerulonephritis (GN, 32.2%), congenital anomalies of the kidney and urinary tract (CAKUT, 21.2%), cystic renal disease (3.9%), renal calcinosis/stone (3.6%), tubulopathy (9.7%), and chronic kidney disease of unknown etiology (CKDu, 5.8%). The pathogenic variants of 105 monogenetic disorders were identified. Ten distinct genomic disorders were identified as pathogenic copy number variants (CNVs) in 11 patients. The diagnostic yield differed by subgroups, and was highest in those with cystic renal disease (66.3%), followed by tubulopathy (58.4%), GN (57.7%), CKDu (43.5%), SRNS (29.2%), renal calcinosis /stone (29.3%) and CAKUT (8.6%). Reverse phenotyping permitted correct identification in 40 cases with clinical reassessment and unexpected genetic conditions. We present the results of the largest cohort of children with kidney disease in China where diagnostic exome sequencing was performed. Our data demonstrate the utility of family-based exome sequencing, and indicate that the combined analysis of genotype and phenotype based on the national patient registry is pivotal to the genetic diagnosis of kidney disease.

Pathways of dissolved unreactive phosphorus loss under long-term crop straw and manure application - Keke Hua; Bo Zhu; Congcong Li (Nutrient Cycling in Agroecosystems, 2021)

Using the Metabolome to Understand the Mechanisms Linking Chronic Arsenic Exposure to Microglia Activation, and Learning and Memory Impairment - Rui-Yuan Zhang; Jie-Bai Tu; Rui-Tu Ran; Wen-Xuan Zhang; Qiang Tan; Ping Tang; Tao Kuang; Shu-Qun Cheng; Cheng-Zhi Chen; Xue-Jun Jiang; Chang Chen; Ting-Li Han; et al. (Neurotoxicity Research, 2021)

RNA-Seq Transcriptome Analysis of the Liver and Brain of the Black Carp (Mylopharyngodon piceus) During Fasting - Ya-Fan Dai; Yu-bang Shen; Shen-Tong Wang; Jia-Hua Zhang; Yu-Hong Su; Sheng-Chen Bao; Xiao-Yan Xu; Jia-Le Li (Marine Biotechnology, 2021)

Soil fertility, enzyme activity, and microbial community structure diversity among different soil textures under different land use types in coastal saline soil - Yun Zhu; Bin Guo; Chen Liu; Yicheng Lin; Qinglin Fu; Ningyu Li; Hua Li (Journal of Soils and Sediments, 2021)

Differences in immunity between pathogen-resistant and -susceptible yam cultivars reveal insights into disease prevention underlying ethylene supplementation - Shumei Hua; Zhihua Chen; Lihong Li; Kuan-Hung Lin; Yangwen Zhang; Jieyu Yang; Shi-Peng Chen (Journal of Plant Biochemistry and Biotechnology, 2021)

A rapid and accurate method for identifying sexuality of Indarbela obliquifasciata Mell (Lepidoptera, Metarbelidae) adults and pupae - Li-Zhi Huo; Long-Hua Sun; Jing-Ai Zhang; Chao Wu; Ya-Hui Hou; Yong-Yue Wang; Zhi-Jie Li; Jia-Ru Deng; Si-Meng Yang; Ke-Ke Bi (International Journal of Tropical Insect Science, 2021)

Intraspecific recurrent selection in V. vinifera: an effective method for breeding of high quality, disease-, cold-, and drought -resistant grapes - Zhi-Lei Wang; Ting-Ting Xue; Fei-Fei Gao; Liang Zhang; Xing Han; Ying Wang; Miao Hui; Dong Wu; Hua Li; Hua Wang (Euphytica, 2021)

Occurrence, distribution, and partitioning of antibiotics in surface water and sediment in a typical tributary of Yellow River, China - Linfang Wang; Hua Li; Jinhua Dang; Hong Guo; Yu’en Zhu; Wenhui Han (Environmental Science and Pollution Research, 2021)

Seasonal variation of nitrogen biogeochemical processes constrained by nitrate dual isotopes in cascade reservoirs, Southwestern China - Sai-Nan Chen; Fu-Jun Yue; Xiao-Long Liu; Jun Zhong; Yuan-Bi Yi; Wan-Fa Wang; Yulin Qi; Hua-Yun Xiao; Si-Liang Li (Environmental Science and Pollution Research, 2021)

The heterogeneous characteristics and their influencing factors of organic matter of saline lacustrine hydrocarbon source rocks - Chenglin Liu; Jixian Tian; Siyuan Xu; Zeqing Guo; Xu Zeng; Pei Li; Sai Yang; Dongshi Ban; Hua Kong; Weiyu Hong (Carbonates and Evaporites, 2021)

Improved AP-3 production through combined ARTP mutagenesis, fermentation optimization, and subsequent genome shuffling - Juan Li; Siyu Guo; Qiang Hua; Fengxian Hu (Biotechnology Letters, 2021)

Disrupted pathways from frontal-parietal cortex to basal ganglia and cerebellum in patients with unmedicated obsessive compulsive disorder as observed by whole-brain resting-state effective connectivity analysis – a small sample pilot study - Wei Liu; Minghui Hua; Jun Qin; Qiuju Tang; Yunyi Han; Hongjun Tian; Daxiang Lian; Zhengqing Zhang; Wenqiang Wang; Chunxiang Wang; Ce Chen; Deguo Jiang; et al. (Brain Imaging and Behavior, 2021)

Altered structural and functional connectivity in CSF1R-related leukoencephalopathy - Fei-Xia Zhan; Ze-Yu Zhu; Qing Liu; Hai-Yan Zhou; Xing-Hua Luan; Xiao-Jun Huang; Xiao-Li Liu; Wo-Tu Tian; Shi-Ge Wang; Xiao-Xuan Song; Guang Chen; Ming-Liang Zhao; et al. (Brain Imaging and Behavior, 2021)

Generation and identification of endothelial-specific Hrh2 knockout mice - Rui Meng; Wen-Ke Cai; Wen-Mang Xu; Qiang Feng; Ping Wang; Yan-hua Huang; Yu-Xin Fan; Tao Zhou; Qin Yang; Zhi-Ran Li; Gong-Hao He (Transgenic Research, 2021)

Spatial distribution pattern in mammal and bird richness and their relationship with ecosystem services in Sanjiangyuan National Park, China - Hua-wei Wan; Hao-xin Li; Jin-hui Wu; Yu-ping Liu (Journal of Mountain Science, 2021)

Erratum to: Spatio-temporal variation of Fraction of Photosynthetically Active Radiation absorbed by vegetation in the Hengduan Mountains, China - Zheng-lan Yang; Ting-bin Zhang; Gui-hua Yi; Jing-ji Li; Yan-bin Qin; Yang Chen (Journal of Mountain Science, 2021)

Ghrelin Affects Gastric Cancer Progression by Activating AMPK Signaling Pathway - Xiao-Lin Hu; Yong-Jun Zhu; Chang-Hua Hu; Li You; Juan Wu; Xiao-Yan He; Wen-Jie Huang; Zong-Hui Wu (Biochemical Genetics, 2021)

Ground roll separation method via threshold filtering and constraint of seismic wavelet support in curvelet domain - De-ying Wang; Li-hua Chen; Lie-qian Dong; Li-hong Zhao; Ren-wei Ding; Cheng-zhen Ding (Applied Geophysics, 2021)

Tritonibacter aquimaris sp. nov. and Tritonibacter litoralis sp. nov., two novel members of the Roseobacter group isolated from coastal seawater - Na Li; Xiao-yan He; Ning-hua Liu; Tie-ji Gu; Jian Li; Yu-hui Geng; Shan Zhang; Peng Wang; Hui-hui Fu; Mei Shi; Xiu-lan Chen; Yu-zhong Zhang; et al. (Antonie van Leeuwenhoek, 2021)

Pigmentibacter ruber gen. nov., sp. nov., a novel bacterium of the family Silvanigrellaceae isolated from human blood - Na Peng; Wen Xu; Hai-Min Luo; Peng-Wen Ouyang; Bin Jiang; Zhi-Hua Zhang; You-De Cao; Li-Ming Tan; Ping-Hua Qu; Liang-Yi Xie (Antonie van Leeuwenhoek, 2021)

Comparison of in Vascular Bioreactors and In Vivo Models of Degradation and Cellular Response of Mg–Zn–Mn Stents - Ningling Zhou; Ping Li; Hua Qiu; Jin Wang; Nan Huang; Ansha Zhao; Juan Wang (Annals of Biomedical Engineering, 2021)

Vertical diversity and association pattern of total, abundant and rare microbial communities in deep‐sea sediments - Yunhui Zhang; Peng Yao; Chuang Sun; Sanzhong Li; Xiaochong Shi; Xiao‐Hua Zhang; Jiwen Liu (Molecular Ecology, 2021)
Microbial abundance and community composition in marine sediments have been widely explored. However, high‐resolution vertical changes of benthic microbial diversity and co‐occurrence patterns are poorly described. The ecological contributions of abundant and rare species in sediments also remain largely unknown. Here, by analysing microbial populations at 14 depth layers of 10 subseafloor sediment cores (water depth 1,250–3,530 m) obtained in the South China Sea, we provided the vertical profiles of microbial β ‐diversity and co‐occurrence influenced by subcommunities of different abundance. These 134 sediment samples were clustered into four groups according to sediment depth (1–2, 6–10, 30–90 and 190–790 cm) with obvious shifts in microbial community compositions. The vertical succession of microorganisms was consistent with redox zonation and influenced by terrestrial inputs. Partitioning of vertical β ‐diversity showed extremely high species replacement between deep layers and the surface layer, indicating selection‐induced loss of rare species and dispersal of dormant cells and spores. By contrast, for horizontal β ‐diversity, richness of rare species became increasingly significant in deep sediments. Accompanying this β ‐diversity profile were clear changes in the association pattern, with microorganisms being less connected in deeper sediment layers, probably reflecting reduced syntrophic interactions. Rare species accounted for an indispensable proportion in the co‐occurrence network, and tended to form complex “small worlds.” The rare subcommunity also responded differently to various environmental factors compared with the abundant subcommunity. Our findings expand current knowledge on vertical changes of marine benthic microbial diversity and their association patterns, emphasizing the potential roles of rare species.

Multiple diversity facets of crucial microbial groups in biological soil crusts promote soil multifunctionality - Hua Li; Youxin Chen; Gongliang Yu; Federico Rossi; Da Huo; Roberto De Philippis; Xiaoli Cheng; Weibo Wang; Renhui Li (Global Ecology and Biogeography, 2021)
Aim Microbial diversity is one of the most important factors for maintaining the performance of multiple functions in soils (multifunctionality). However, existing studies typically consider the taxonomic richness or Shannon diversity of the entire community. We know little about the connection network of taxonomic and phylogenetic facets of diversity and their collective impact on multifunctionality. In this study, the linkages of effects of diversity within functional groups were disentangled in drylands. Location The central Tibetan Plateau. Time period Present. Major taxa studied Phototrophs and diazotrophs (mainly cyanobacteria). Methods Given the carbon‐ and nitrogen‐limited nature of drylands, we conducted a high‐throughput sequencing of C/N‐fixing functional groups from biocrusts and evaluated multiple facets of diversity (i.e., richness, evenness and phylogeny‐related trait dissimilarity), together with seven crucial variables of soil functioning to calculate multifunctionality. The relationships between multifaceted diversity and abundance with individual functions and multifunctionality were validated by a set of solid statistical analyses. Results We found that the integrated biodiversity index was a stronger predictor of multifunctionality than richness. The divergent performance of different facets of diversity determined the idiosyncratic effect of each functional group on soil multifunctionality. Moreover, the evaluation of functional significance at the species level gave important clues on the trade‐offs and redundancy in each functional group, explaining the distinct patterns of effects of diversity. Richness was the dominant factor for diazotrophs to maximize multifunctionality, whereas phylogenetic dissimilarity was the essential one for phototrophs. Main conclusions Our study demonstrated that multiple facets of diversity should be considered when assessing the effects of biodiversity. In contrast to the community level, within‐functional group measures might adequately capture the features of diversity that are most correlated with soil multifunctionality. Our results provide a perspective to bridge the gap between taxonomic and trait‐based approaches for elucidating the biodiversity–ecosystem function relationship.

Simulation and test of the movement process of mixed flow composed of slurry and coarse particle - Xian-jun Ji; Ying Liang; Guo-qiang Ou; Hua-li Pan (European Journal of Environmental and Civil Engineering, 2021)

Prediction model based on the Laplacian eigenmap method combined with a random forest algorithm for rainstorm satellite images during the first annual rainy season in South China - Xiao-yan Huang; Li He; Hua-sheng Zhao; Ying Huang; Yu-shuang Wu (Natural Hazards, 2021)

Resolvin D1 Attenuates Innate Immune Reactions in Experimental Subarachnoid Hemorrhage Rat Model - Guang-Jie Liu; Tao Tao; Xiang-Sheng Zhang; Yue Lu; Ling-Yun Wu; Yong-Yue Gao; Han Wang; Hai-Bin Dai; Yan Zhou; Zong Zhuang; Chun-Hua Hang; Wei Li (Molecular Neurobiology, 2021)

Cultivation of uncultured marine microorganisms - Fengping Wang; Meng Li; Li Huang; Xiao-Hua Zhang (Marine Life Science & Technology, 2021)

Diversity, metabolism and cultivation of archaea in mangrove ecosystems - Cui-Jing Zhang; Yu-Lian Chen; Yi-Hua Sun; Jie Pan; Ming-Wei Cai; Meng Li (Marine Life Science & Technology, 2021)

First report of Alternaria alternata causing leaf spots of Liriodendron chinense × tulipifera in China - Guan-Qun Jin; Guang-Yao Mao; De-Wei Li; Yu Wan; Li-Hua Zhu (Journal of Plant Pathology, 2021)

Bjerkandera adusta M1 inhibits the growth of Fusarium oxysporum f. sp. conglutinans and fusarium wilt incidence in Brassica napus L. - Xiao Feng; Su-Ping Li; Yi-Fan Lu; Jing-Jie Zhang; Yun-Yun Zhu; Yong Li; Hong-Jun Yang; Xin-Hua He (Journal of Plant Pathology, 2021)

Morphology and molecular phylogeny of three species of Coolia (Dinophyceae) from Hainan Island, South China Sea - Hua Zhang; Songhui Lü; Jingyi Cen; Yang Li; Qun Li; Zhen Wu (Journal of Oceanology and Limnology, 2021)

Establishment and characterization of 38 novel patient-derived primary cancer cell lines using multi-region sampling revealing intra-tumor heterogeneity of gallbladder carcinoma - Feiling Feng; Qingbao Cheng; Bin Li; Chen Liu; Huizhen Wang; Bin Li; Xiaoya Xu; Yong Yu; Zishuo Chen; Xiaobing Wu; Hua Dong; Kaijian Chu; et al. (Human Cell, 2021)
Gallbladder carcinoma (GBC) is a lethal biliary tract malignant neoplasm. Patient-derived primary cancer cell lines (PDPCs) are appropriate models to explore biological characteristics and potential therapeutics; however, there is a lack of PDPCs in GBC. In this study, we aimed to establish and characterize the GBC PDPCs, and further investigated the intra-tumor heterogeneity (ITH). Multi-region sampling (3–9 regions) of the operable tumor tissue samples was used to establish PDPCs. Short tandem repeat genotyping for cell authentication and karyotyping was performed, followed by whole-exome sequencing and RNA sequencing to assess the ITH at the genetic and transcriptional levels, respectively. Thirty-eight PDPCs were successfully established from seven GBC patients and characterized. ITH was observed with a median of 38.3% mutations being heterogeneous (range, 26.6–59.4%) across all patients. Similar with other tumor types, TP53 mutations were always truncal. In addition, there were three genes, KMT2C , CDKN2A , and ARID1A , with truncal mutations in at least two patients. A median of 370 differentially expressed genes (DEGs) was identified per patient. Distinct expression patterns were observed between major histocompatibility complex (MHC) class I and II genes. We found the expression of MHC class II genes in the PDPC samples was closely regulated by CIITA , while that of MHC class I genes were not correlated with CIITA expression. The PDPCs established from GBC patients can serve as novel in vitro models to identify the ITH, which may pave a crucial molecular foundation for enhanced understanding of tumorigenesis and progression.

Optimization of LED fishing lamp allocation based on numerical modeling in Pacific saury fishery - Fei Li; Chuanxiang Hua; Qingcheng Zhu; Liming Song (Fisheries Science, 2021)

Electrochemical performance and response of bacterial community during phenanthrene degradation in single-chamber air-cathode microbial fuel cells - Tao Hua; Haonan Wang; Shengnan Li; Peng Chen; Fengxiang Li; Wei Wang (Environmental Science and Pollution Research, 2021)

ZnO nanorods/Fe3O4-graphene oxide/metal-organic framework nanocomposite: recyclable and robust photocatalyst for degradation of pharmaceutical pollutants - Li Chen; Jun Peng; Fangqi Wang; Donghao Liu; Wenrong Ma; Jinmeng Zhang; Wenqing Hu; Ning Li; Pierre Dramou; Hua He (Environmental Science and Pollution Research, 2021)

Di-(2-ethylhexyl) phthalate induces testicular endoplasmic reticulum stress and germ cell apoptosis in adolescent mice - Bin-Bin Zhu; Zhi-Cheng Zhang; Jian Li; Xing-Xing Gao; Yuan-Hua Chen; Hua Wang; Lan Gao; De-Xiang Xu (Environmental Science and Pollution Research, 2021)

Paenibacillus puerhi sp. nov., isolated from the rhizosphere soil of Pu-erh tea plants (Camellia sinensis var. assamica) - Rui-Juan Yang; De Zhou; Qiao-Mei Wang; Xing-Hua Wang; Wen-Jie Zhang; Li Zhuang; Xuan-Jun Wang; Liang Yan; Jie Lv; Jun Sheng (Archives of Microbiology, 2021)

Influence of major water conservation projects on river channels and shorelines in the middle and lower reaches of the Yangtze River - Yue-hua Jiang; He-qin Cheng; Quan-ping Zhou; Yun Li; Guo-qiang Yang; Yang Jin; Shi-jia Mei; Xuan Gu; Hong Zhang (Arabian Journal of Geosciences, 2021)

Impacts of land use change on thermodynamic and dynamic changes of precipitation for the Yangtze River Basin, China - Qian Lin; Jie Chen; Wei Li; Kailin Huang; Xuezhi Tan; Hua Chen (International Journal of Climatology, 2021)
Many studies found that land use change (LUC) had great impacts on regional precipitation, due to thermodynamic and dynamic responses. However, the relative contributions of these two factors to changes in precipitation due to LUC are rarely investigated. This study quantifies the relative contributions of thermodynamic and dynamic to the changes of mean and extreme precipitation due to LUC based on simulations of the Weather Research and Forecasting (WRF) model. The Yangtze River Basin (YRB) is used as a case study, as it has experienced great LUC during the past decades. Four land use scenarios (two factual cases and two hypothetical reforestation scenarios) were used to test the sensitivity of precipitation changes to LUC. Changes in mean and extreme precipitation over the YRB for all seasons are attributed to thermodynamic and dynamic changes using 500‐hPa geopotential height and precipitation data derived from the simulations of WRF. The results show that the factual process of LUC results in a decrease in summer mean daily precipitation and precipitation extremes in most areas of the YRB (except for the middle reaches of the YRB), while the hypothetical reforestation contributes to an increase in summer mean and extreme precipitation, and the impacts of reforestation on increasing precipitation are limited. The thermodynamic change contributes to an increase in seasonal mean daily precipitation, extreme precipitation totals and occurrence frequency of precipitation extremes with contributions ranging from 94 to 102%, which is the main contributor of changes in precipitation due to LUC. The dynamic change only makes a small contribution to the change of precipitation. Because the contributions of thermodynamic can be offset by dynamic changes to changes in precipitation, it could result in minimal changes in precipitation and occurrences of precipitation extremes.

Development of Apremilast Solid Dispersion Using TPGS and PVPVA with Enhanced Solubility and Bioavailability - Liuhong Yang; Penghui Wu; Jinchao Xu; Dihuan Xie; Zhongqing Wang; Qian Wang; Yong Chen; Chuan Hua Li; Jiaxin Zhang; Hangping Chen; Guilan Quan (AAPS PharmSciTech, 2021)

A hierarchical object detection method in large-scale optical remote sensing satellite imagery using saliency detection and CNN - Zhina Song; Haigang Sui; Li Hua (International Journal of Remote Sensing, 2021)

Dental Pulp Stem Cell-Derived Extracellular Vesicles Mitigate Haematopoietic Damage after Radiation - Fanxuan Kong; Chu-Tse Wu; Panpan Geng; Chao Liu; Fengjun Xiao; Li-Sheng Wang; Hua Wang (Stem Cell Reviews and Reports, 2021)
Radiation therapy can cause haematopoietic damage, and mesenchymal stem cells (MSCs) derived extracellular vesicles (EVs) have been shown to reverse this damage. Our previous research showed that dental pulp stem cells (DPSCs) have a strong proliferation capacity and can produce abundant amounts of EVs to meet the requirements for use in vitro and in vivo. DPSCs derived EVs (DPSCs-EVs) are evaluated for their effect on reducing haematopoietic damage. Haematopoietic stem cell (HSC) numbers and function were assessed by flow cytometry, peripheral blood cell counts, histology and bone marrow transplantation. Epidermal growth factor (EGF) was used as a reference for evaluating the efficiency of EVs. miRNA microarray was employed to find out the changes of miRNA expression after cells being irradiated in vivo and the role they may play in mitigation the radiation caused injury. We observed the effect of DPSCs-EVs on promoting proliferation and inhibiting apoptosis of human umbilical vein endothelial cells (HUVECs) and FDC-P1 cells in vitro. We found that DPSCs-EVs and EGF could comparably inhibit the decrease in WBC, CFU count and KSL cells in vivo. We also verified that EVs could accelerate the recovery of long-term HSCs. In summary, DPSCs-EVs showed an apoptosis resistant effect on HUVECs and FDC-P1 cells after radiation injury in vitro. EVs from DPSCs were comparable to EGF in their ability to regulate haematopoietic regeneration after radiation injury in vivo. Radiation could alter the expression of some miRNAs in bone marrow cells, and EVs could correct these changes to some extent.

Evaluation of the efficacy and safety of hydroxychloroquine in comparison with chloroquine in moderate and severe patients with COVID-19 - Qiuyu Li; Cheng Cui; Fei Xu; Jianping Zhao; Nan Li; Haichao Li; Tianbing Wang; Hua Zhang; Na Liu; Yudong Wei; Xiaoye Niu; Yan Xu; et al. (Science China Life Sciences, 2021)

Tweety-Homolog 1 Facilitates Pain via Enhancement of Nociceptor Excitability and Spinal Synaptic Transmission - Wen-Juan Han; Sui-Bin Ma; Wen-Bin Wu; Fu-Dong Wang; Xiu-Li Cao; Dong-Hao Wang; Hai-Ning Wu; Rou-Gang Xie; Zhen-Zhen Li; Fei Wang; Sheng-Xi Wu; Min-Hua Zheng; et al. (Neuroscience Bulletin, 2021)

Expressions and related mechanisms of miR-212 and KLF4 in rats with acute kidney injury - Xingguan Yang; Bo Li; Yu Guan; Hua-Mao Jiang (Molecular and Cellular Biochemistry, 2021)

The Roles of Epinephelus coioides miR-122 in SGIV Infection and Replication - Hong-Yan Sun; Yu-Ling Su; Pin-Hong Li; Jia-Yang He; He-Jia Chen; Gang Wang; Shao-Wen Wang; Xiao-Hong Huang; You-Hua Huang; Qi-Wei Qin (Marine Biotechnology, 2021)
In mammals, mature miR-122 is 22 nucleotides long and can be involved in regulating a variety of physiological and biological pathways. In this study, the expression profile and effects of grouper Epinephelus coioides miR-122 response to Singapore grouper iridovirus (SGIV) infection were investigated. The sequences of mature microRNAs (miRNAs) from different organisms are highly conserved, and miR-122 from E. coioides exhibits high similarity to that from mammals and other fish. The expression of miR-122 was up-regulated during SGIV infection. Up-regulation of miR-122 could significantly enhance the cytopathic effects (CPE) induced by SGIV, the transcription levels of viral genes (MCP, VP19, LITAF and ICP18), and viral replication; reduce the expression of inflammatory factors (TNF-a, IL-6, and IL-8), and the activity of AP-1 and NF-κB, and miR-122 can bind the target gene p38α MAPK to regulate the SGIV-induced cell apoptosis and the protease activity of caspase-3. The results indicated that SGIV infection can up-regulate the expression of E. coioides miR-122, and up-regulation of miR-122 can affect the activation of inflammatory factors, the activity of AP-1 and NF-κB, and cell apoptosis to regulate viral replication and proliferation.

A novel Schiff base cobalt(III) complex induces a synergistic effect on cervical cancer cells by arresting early apoptosis stage - Wen-Hui Liao; Xue-Qing Song; Yan-Jie Kong; Rui-Dan Bao; Fang-Fang Li; Jie Zhou; Qi-Hua Zhao; Jing-Yuan Xu; Ni Xie; Ming-Jin Xie (BioMetals, 2021)

Spatio-temporal variation of Fraction of Photosynthetically Active Radiation absorbed by vegetation in the Hengduan Mountains, China - Zheng-Ian Yang; Ting-bin Zhang; Gui-hua Yi; Jing-ji Li; Yan-bin Qin; Yang Chen (Journal of Mountain Science, 2021)

Spatial Distribution and Ecological Risk Assessment of Heavy Metals in Surface Sediment of Songhua River, Northeast China - Baolin Liu; Deming Dong; Xiuyi Hua; Weihua Dong; Ming Li (Chinese Geographical Science, 2021)

Relationships between the sound speed ratio and physical properties of surface sediments in the South Yellow Sea - Guanbao Li; Jingqiang Wang; Xiangmei Meng; Baohua Liu; Guangming Kan; Guozhong Han; Qingfeng Hua; Yanliang Pei; Lei Sun (Acta Oceanologica Sinica, 2021)

Simultaneous detection of multiple bacterial and viral aquatic pathogens using a fluorogenic loop‐mediated isothermal amplification‐based dual‐sample microfluidic chip - Qian‐Jin Zhou; Jian‐Fei Lu; Xiu‐Rong Su; Jing‐Lei Jin; Shang‐Yang Li; Yan Zhou; Lei Wang; Xin‐Bin Shao; Yao‐Hua Wang; Mao‐Cang Yan; Ming‐Yun Li; Jiong Chen (Journal of Fish Diseases, 2021)
Rapid and user‐friendly diagnostic tests are necessary for early diagnosis and immediate detection of diseases, particularly for on‐site screening of pathogenic microorganisms in aquaculture. In this study, we developed a dual‐sample microfluidic chip integrated with a real‐time fluorogenic loop‐mediated isothermal amplification assay (dual‐sample on‐chip LAMP) to simultaneously detect 10 pathogenic microorganisms, that is Aeromonas hydrophila , Edwardsiella tarda , Vibrio harveyi , V. alginolyticus , V. anguillarum , V. parahaemolyticus , V. vulnificus , infectious hypodermal and haematopoietic necrosis virus, infectious spleen and kidney necrosis virus, and white spot syndrome virus. This on‐chip LAMP provided a nearly automated protocol that can analyse two samples simultaneously, and the tests achieved limits of detection (LOD) ranging from 10 0 to 10 –1 pg/μl for genomic DNA of tested bacteria and 10 –4 to 10 –5 pg/μl for recombinant plasmid DNA of tested viruses, with run times averaging less than 30 min. The coefficient of variation for the time‐to‐positive value was less than 10%, reflecting a robust reproducibility. The clinical sensitivity and specificity were 93.52% and 85.53%, respectively, compared to conventional microbiological or clinical methods. The on‐chip LAMP assay provides an effective dual‐sample and multiple pathogen analysis, and thus would be applicable to on‐site detection and routine monitoring of multiple pathogens in aquaculture.

Biotechnology and bioengineering of pullulanase: state of the art and perspectives - Pei Xu; Shi-Yu Zhang; Zhi-Gang Luo; Min-Hua Zong; Xiao-Xi Li; Wen-Yong Lou (World Journal of Microbiology and Biotechnology, 2021)

Design of the bionic wheel surface based on the friction characteristics of ostrich planta - Hao Pang; Hua Zhang; Rui Zhang; Wenchao Dong; Tao Li; Songsong Ma; Jianqiao Li (Rendiconti Lincei. Scienze Fisiche e Naturali, 2021)

Effect of bFGF on fibroblasts derived from the golden snub-nosed monkey - Xin Liu; Hao Wei; Jing Yang; Jingjing Li; Pei Zhang; Yuli Li; Rong Hou; Jinlian Hua; Xingrong Yan; Baoguo Li (Primates, 2021)

Spatial distribution and environmental significance of phytoliths in the surface soil of the Xilingol Grassland in Inner Mongolia, China - Chong-Xiao Sun; Hua Su; Cai-Qing Guo; Zhi-Wei Liu; Ya-Meng Li; Feng Qin; Hai-Ming Liu (Palaeobiodiversity and Palaeoenvironments, 2021)

TRAK1-Mediated Abnormality of Mitochondrial Fission Increases Seizure Susceptibility in Temporal Lobe Epilepsy - Hao Wu; Yong Liu; Huanfa Li; Changwang Du; Kuo Li; Shan Dong; Qiang Meng; Hua Zhang (Molecular Neurobiology, 2021)

NGF-Induced Nav1.7 Upregulation Contributes to Chronic Post-surgical Pain by Activating SGK1-Dependent Nedd4-2 Phosphorylation - Bao-Wen Liu; Jin Zhang; Yi-Shun Hong; Ning-Bo Li; Yi Liu; Mi Zhang; Wen-Yao Wu; Hua Zheng; Angelika Lampert; Xian-Wei Zhang (Molecular Neurobiology, 2021)

EPG-recorded Feeding Behaviors Reveal Adaptability and Competitiveness in Two Species of Bemisia tabaci (Hemiptera: Aleyrodidae) - Shao-hua Lu; Jing-jing Li; Run-e Bai; Feng-ming Yan (Journal of Insect Behavior, 2021)

Effect of nitenpyram on the control of Reticulitermes flaviceps - Jiachang Zhou; Yang Bai; Hua Zhong; Ganghua Li (International Journal of Tropical Insect Science, 2021)

Effects of ionic liquid [N4444] AOT on rice seedling growth cytomembrane damage and rhizobacteria resistance - Junkang Guo; Geng Cao; Qian Ren; Huiyun Xu; Xinhao Ren; Honglei Jia; Li Hua; Ting Wei; Shenghui Yu (Environmental Science and Pollution Research, 2021)

Occurrence and risk evaluation of organophosphorus flame retardants in two urban rivers in Yangtze River Delta - Enmiao Jiao; Xiaohui Hu; Li Li; Hua Zhang; Zhiliang Zhu; Daqiang Yin; Yanling Qiu (Environmental Monitoring and Assessment, 2021)

Change detection in SAR images based on superpixel segmentation and image regression - Rui Zhao; Guo-Hua Peng; Wei-dong Yan; Lu-Lu Pan; Li-Ya Wang (Earth Science Informatics, 2021)

Attenuation of Cardiomyocyte Hypertrophy via Depletion Myh7 using CASAAV - Peng Yue; Shutao Xia; Gang Wu; Lei Liu; Kaiyu Zhou; Hongyu Liao; Jiawen Li; Xiaolan Zheng; Yuxuan Guo; Yimin Hua; Donghui Zhang; Yifei Li (Cardiovascular Toxicology, 2021)

Dolomitization of the Middle Ordovician Ma55 Sub-member of the Majiagou Formation and implications for hydrocarbon exploration in the northern Ordos Basin, NW China - Hua Liu; Pingzhou Shi; Hongming Tang; Zhenyu Wang; Ting Shang; Zhongjun Zhao; Longlong Li; Kaixuan Liu (Carbonates and Evaporites, 2021)

Cortical Hemodynamic Response Associated with Spatial Coding: A Near-Infrared Spectroscopy Study - Abiot Y. Derbie; Bolton Chau; Bess Lam; Yun-hua Fang; Kin-Hung Ting; Clive Y. H. Wong; Jing Tao; Li-dian Chen; Chetwyn C. H. Chan (Brain Topography, 2021)

Soil amendment in plastic greenhouse using modified biochar: soil bacterial diversity responses and microbial biomass carbon and nitrogen - Bin Hua; Zhouwen Li; Weikai Gao; Huilin Feng; Nan Chen; Jiayi Li; Xiaoming Ji; Lu Zhang; Zhiyong Wu; Shen Yan; Tianbao Ren; Chensheng Xu; et al. (Biotechnology Letters, 2021)

Arbuscular mycorrhizal colonization rate of an exotic plant, Galinsoga quadriradiata, in mountain ranges changes with altitude - Gang Liu; Rui-Ling Liu; Wen-Gang Zhang; Ying-Bo Yang; Xiao-Qiong Bi; Ming-Zhu Li; Xiao-Yan Chen; Hua Nie; Zhi-Hong Zhu (Mycorrhiza, 2021)

Effects of degradation succession of alpine wetland on soil organic carbon and total nitrogen in the Yellow River source zone, west China - Chun-ying Lin; Xi-lai Li; Jing Zhang; Hua-fang Sun; Juan Zhang; Hui-bang Han; Qi-hua Wang; Cheng-biao Ma; Cheng-yi Li; Yu-xing Zhang; Xue-qian Ma (Journal of Mountain Science, 2021)

Genomic characterization of a nebovirus strain with a novel RdRp genotype in yaks - Siyi Li; Huiqiang Ma; Zhonghua Yu; Hua Yue; Cheng Tang (Archives of Virology, 2021)

Host genetics and gut microbiota cooperatively contribute to azoxymethane-induced acute toxicity in Collaborative Cross mice - Chenhan Zhong; Li He; Sun-Young Lee; Hang Chang; Yuqing Zhang; David W. Threadgill; Ying Yuan; Fuling Zhou; Susan E. Celniker; Yankai Xia; Antoine M. Snijders; Jian-Hua Mao (Archives of Toxicology, 2021)

Least-squares reverse time migration method using the factorization of the Hessian matrix - Sun Xiao-Dong; Teng Hou-Hua; Ren Li-Juan; Wang Wei-Qi; Li Zhen-Chun (Applied Geophysics, 2021)

Tectonic implications of the subduction of the Kyushu-Palau Ridge beneath the Kyushu, southwest Japan - Chenglong Xia; Yanpeng Zheng; Baohua Liu; Qingfeng Hua; Long Ma; Xianfeng Li; Qiuhong Xie (Acta Oceanologica Sinica, 2021)

Alkaloids and phenylpropanoid from Rhizomes of Arundo donax L - Qing-Ru Liu; Juan Li; Xiao-Fang Zhao; Bo Xu; Xing-Hua Xiao; Jie Ren; Shun-Xiang Li (Natural Product Research, 2021)

Adsorption Separation of CO2/CH4 from Landfill Gas by Ethanolamine-Modified Silica Gel - Yong Zhang; Kejin Chen; Chao Lv; Taijun Wu; Yonglin Wen; Hua He; Sheng Yu; Li’ao Wang (Water, Air, & Soil Pollution, 2021)

Long-term Outcomes and Risk Factors Related to Hydrocephalus After Intracerebral Hemorrhage - Rong Hu; Chao Zhang; Jiesheng Xia; Hongfei Ge; Jun Zhong; Xuanyu Fang; Yongjie Zou; Chuan Lan; Lan Li; Hua Feng (Translational Stroke Research, 2021)

Multiple origins of Indian dwarf wheat by mutations targeting the TREE domain of a GSK3-like kinase for drought tolerance, phosphate uptake, and grain quality - Ajay Gupta; Lei Hua; Guifang Lin; Istváan Molnár; Jaroslav Doležel; Sanzhen Liu; Wanlong Li (Theoretical and Applied Genetics, 2021)

The MYB transcription factor Baymax1 plays a critical role in rice male fertility - Xiao-Jiao Xiang; Lian-Ping Sun; Ping Yu; Zheng-Fu Yang; Pei-Pei Zhang; Ying-Xin Zhang; Wei-Xun Wu; Dai-Bo Chen; Xiao-Deng Zhan; Riaz-Muhammad Khan; Adil Abbas; Shi-Hua Cheng; et al. (Theoretical and Applied Genetics, 2021)

Small RNA Sequencing Analysis of Germinating Single-bud Seedcane Sett in Sugarcane - Kai-Chao Wu; Lin Xu; Zhi-Nian Deng; Tian Pang; Rong-Hua Zhang; Yi-Jie Li; Xiao-Yan Liu; Cheng-Feng Huang; Wen-Xian Qin; Jian-Feng Wei; Li-Ping Wei; Yang-Rui Li; et al. (Sugar Tech, 2021)

Down-regulation of MANNANASE7 gene in Brassica napus L. enhances silique dehiscence-resistance - Yu-Long Li; Yan-Kun Yu; Ke-Ming Zhu; Li-Na Ding; Zheng Wang; Yan-Hua Yang; Jun Cao; Li-Zhang Xu; Yao-Ming Li; Xiao-Li Tan (Plant Cell Reports, 2021)

Ferroptosis occurs in phase of reperfusion but not ischemia in rat heart following ischemia or ischemia/reperfusion - Li-Jing Tang; Xiu-Ju Luo; Hua Tu; Heng Chen; Xiao-Ming Xiong; Nian-Sheng Li; Jun Peng (Naunyn-Schmiedeberg's Archives of Pharmacology, 2021)

Interaction between DMRT1 and PLZF protein regulates self-renewal and proliferation in male germline stem cells - Yudong Wei; Donghui Yang; Xiaomin Du; Xiuwei Yu; Mengfei Zhang; Furong Tang; Fanglin Ma; Na Li; Chunling Bai; Guangpeng Li; Jinlian Hua (Molecular and Cellular Biochemistry, 2021)

TMEM166 inhibits cell proliferation, migration and invasion in hepatocellular carcinoma via upregulating TP53 - Jiejie Yang; Bin Wang; Qian Xu; Yuling Yang; Lin Hou; Kan Yin; Qingming Guo; Yanan Hua; Li Zhang; Yixuan Li; Jinyu Zhang; Ning Li (Molecular and Cellular Biochemistry, 2021)

Deep Placement of Nitrogen Fertilizer Affects Grain Yield, Nitrogen Recovery Efficiency, and Root Characteristics in Direct-Seeded Rice in South China - Yunyan Chen; Pingshan Fan; Zhaowen Mo; Leilei Kong; Hua Tian; Meiyang Duan; Lin Li; Liji Wu; Zaimang Wang; Xiangru Tang; Shenggang Pan (Journal of Plant Growth Regulation, 2021)

Study on Physiological Mechanism of Using Cottonseed Meal to Improve Salt–Alkali Tolerance of Cotton - Hongxiu Ma; Chunmei Meng; Kaixiang Zhang; Kaiyong Wang; Hua Fan; Yingbin Li (Journal of Plant Growth Regulation, 2021)

Regulation of peroxisome proliferator-activated receptor-gamma activity affects the hepatic stellate cell activation and the progression of NASH via TGF-β1/Smad signaling pathway - Xi-Xi Ni; Xiao-Yun Li; Qi Wang; Jing Hua (Journal of Physiology and Biochemistry, 2021)

The role of MYB proto-oncogene like 2 in tamoxifen resistance in breast cancer - Xia Li; Xi Zhang; Cong-Cong Wu; Ping-Ping Li; Yi-Mou Fu; Li-Hua Xie; Shuang-Shuang Sun; Ying-Ying Zhou; Bao-Ling Zhu (Journal of Molecular Histology, 2021)

Genetic and epigenetic variations in barley (Hordeum vulgare L.) using SSR and MSAP approaches - Bo Li; Qiang Gong; Wei Hua; Gonghai Chen; Wenying Zhang; Yanhao Xu; Chengdao Li (Genetic Resources and Crop Evolution, 2021)

Study on Rock Burst Prediction of Deep Buried Tunnel Based on Cusp Catastrophe Theory - Chen Qiao; Yan-hua Guo; Chang-hong Li (Geotechnical and Geological Engineering, 2021)

The reproductive regulation of LPXRFa and its receptor in the hypothalamo-pituitary-gonadal axis of the spotted scat (Scatophagus argus) - Yi Zhai; Si-Ping Deng; Jian-Ye Liu; Dong-Neng Jiang; Yang Huang; Chun-Hua Zhu; Guang-Li Li; Ming-Hui Li (Fish Physiology and Biochemistry, 2021)

EDTAD-modified cassava stalks loaded with Fe3O4: highly efficient removal of Pb2+ and Zn2+ from aqueous solution - Caiyan Kang; Qiuyan Li; Hui Yi; Hua Deng; Weiming Mo; Mianwu Meng; Siyu Huang (Environmental Science and Pollution Research, 2021)

Abscisic acid modulates differential physiological and biochemical responses of roots, stems, and leaves in mung bean seedlings to cadmium stress - Yan Leng; Yi Li; Yan-Hua Ma; Li-Fang He; Shi-Weng Li (Environmental Science and Pollution Research, 2021)

Copper metabolism in Saccharomyces cerevisiae: an update - Hua Shi; Yunhui Jiang; Yang Yang; Yougong Peng; Chenghua Li (BioMetals, 2021)

Transcriptome reveals genes involving in black skin color formation of ducks - Lei Wang; Hehe Liu; Bo Hu; Jiwei Hu; Hengyong Xu; Hua He; Chunchun Han; Bo Kang; Lili Bai; Rongping Zhang; Jiwen Wang; Shengqiang Hu; et al. (Genes & Genomics, 2021)

Comparative proteomic study on fem-1b in female and male gonads in Hyriopsis cumingii - Ya-Yu Wang; Sheng-Hua Duan; Sai-Sai Dong; Xiao-Yu Cui; Gui-Ling Wang; Jia-Le Li (Aquaculture International, 2021)

NUIST ESM v3 Data Submission to CMIP6 - Jian Cao; Libin Ma; Fei Liu; Jing Chai; Haikun Zhao; Qiong He; Bo Wang; Yan Bao; Juan Li; Young-min Yang; Hua Deng; Bin Wang (Advances in Atmospheric Sciences, 2021)
This paper introduces the experimental designs and outputs of the Diagnostic, Evaluation and Characterization of Klima (DECK), historical, Scenario Model Intercomparison Project (MIP), and Paleoclimate MIP (PMIP) experiments from the Nanjing University of Information Science and Technology Earth System Model version 3 (NESM3). Results show that NESM3 reasonably simulates the modern climate and the major internal modes of climate variability. In the Scenario MIP experiment, changes in the projected surface air temperature (SAT) show robust “Northern Hemisphere (NH) warmer than Southern Hemisphere (SH)” and “land warmer than ocean” patterns, as well as an El Niño-like warming over the tropical Pacific. Changes in the projected precipitation exhibit “NH wetter than SH” and “eastern hemisphere gets wetter and western hemisphere gets drier” patterns over the tropics. These precipitation patterns are driven by circulation changes owing to the inhomogeneous warming patterns. Two PMIP experiments show enlarged seasonal cycles of SAT and precipitation over the NH due to the seasonal redistribution of solar radiation. Changes in the climatological mean SAT, precipitation, and ENSO amplitudes are consistent with the results from PMIP4 models. The NESM3 outputs are available on the Earth System Grid Federation nodes for data users.

The CMIP6 Historical Simulation Datasets Produced by the Climate System Model CAMS-CSM - Xinyao Rong; Jian Li; Haoming Chen; Jingzhi Su; Lijuan Hua; Zhengqiu Zhang; Yufei Xin (Advances in Atmospheric Sciences, 2021)
This paper describes the historical simulations produced by the Chinese Academy of Meteorological Sciences (CAMS) climate system model (CAMS-CSM), which are contributing to phase 6 of the Coupled Model Intercomparison Project (CMIP6). The model description, experiment design and model outputs are presented. Three members’ historical experiments are conducted by CAMS-CSM, with two members starting from different initial conditions, and one excluding the stratospheric aerosol to identify the effect of volcanic eruptions. The outputs of the historical experiments are also validated using observational data. It is found that the model can reproduce the climatological mean states and seasonal cycle of the major climate system quantities, including the surface air temperature, precipitation, and the equatorial thermocline. The long-term trend of air temperature and precipitation is also reasonably captured by CAMS-CSM. There are still some biases in the model that need further improvement. This paper can help the users to better understand the performance and the datasets of CAMS-CSM.

Community structure of bacterioplankton and its relationship with environmental factors in the upper reaches of the Heihe River in Qinghai Plateau - Zhang Qian‐Qian; Jian Sheng‐Long; Li Ke‐Mao; Wu Zhen‐Bing; Guan Hong‐Tao; Hao Jin‐Wen; Wang Shu‐Yi; Lin Yao‐Yao; Wang Guo‐Jie; Li Ai‐Hua (Environmental Microbiology, 2021)
Summary Planktonic microorganisms play a key role in the biogeochemical processes of the aquatic system, and they may be affected by many factors. High‐throughput sequencing technology was used in this study to investigate and study the bacterioplankton community of water bodies in the upper reaches of the Heihe River Basin in Qinghai Plateau. Results showed that Proteobacteria, Firmicutes, Bacteroidetes and Actinobacteria are the predominant phyla in this river section, while the main genera are Thiomonas , Acidibacillus , Acidocella , Rhodanobacter , Acidithiobacter and Gallionella , which are autochthonous in the acid‐mine drainage. Additionally, total nitrogen, total phosphorus, permanganate index and pH are significantly correlated with the bacterioplankton abundance and are the main limiting factors for the spatial distribution of the bacterioplankton. PICRUSt inferred that the mainstream microbial assemblages had a higher abundance of KOs belong to metabolism of terpenoids and polyketides, while the tributary had higher abundance of KOs belong to the immune system. The relationship between bacterioplankton community composition and environmental factors in the Heihe River basin was discussed for the first time in this study, which provides a theoretical basis for the healthy, orderly development of the water environment in the Heihe River Basin.

Harnessing the type I CRISPR‐Cas systems for genome editing in prokaryotes - Zeling Xu; Yanran Li; Ming Li; Hua Xiang; Aixin Yan (Environmental Microbiology, 2021)
Summary Genetic analysis is crucial to the understanding, exploitation, and control of microorganisms. The advent of CRISPR‐Cas‐based genome‐editing techniques, particularly those mediated by the single‐effector (Cas9 and Cas12a) class 2 CRISPR‐Cas systems, has revolutionized the genetics in model eukaryotic organisms. However, their applications in prokaryotes are rather limited, largely owing to the exceptional diversity of DNA homeostasis in microorganisms and severe cytotoxicity of overexpressing these nuclease proteins in certain genotypes. Remarkably, CRISPR‐Cas systems belonging to different classes and types are continuously identified in prokaryotic genomes and serve as a deep reservoir for expansion of the CRISPR‐based genetic toolkits. ~90% of the CRISPR‐Cas systems identified so far belong to the class 1 system which hinges on multi‐protein effector complexes for DNA interference. Harnessing these widespread native CRISPR‐Cas systems for ‘built‐in’ genome editing represents an emerging and powerful genetic tool in prokaryotes, especially in the genetically recalcitrant non‐model species and strains. In this progress review, we introduce the general workflow of this emerging editing platform and summarize its establishment in a growing number of prokaryotes by harnessing the most widespread, diverse type I CRISPR‐Cas systems present in their genomes. We also discuss the various factors affecting the success and efficiency of this editing platform and the corresponding solutions.

Speciation and Release Kinetics Simulation of Zn and Cd from River Sediment Contaminated by Gold Mining - Yongbing Cai; Ning Xu; Fande Meng; Feiyue Li; Yue Xie; Hua Zhang (Water, Air, & Soil Pollution, 2021)

Modes of genetic adaptations underlying functional innovations in the rumen - Xiangyu Pan; Yudong Cai; Zongjun Li; Xianqing Chen; Rasmus Heller; Nini Wang; Yu Wang; Chen Zhao; Yong Wang; Han Xu; Songhai Li; Ming Li; et al. (Science China Life Sciences, 2021)

IbERF71, with IbMYB340 and IbbHLH2, coregulates anthocyanin accumulation by binding to the IbANS1 promoter in purple-fleshed sweet potato (Ipomoea batatas L.) - Zhiyuan Ning; Kangdi Hu; Zhilin Zhou; Donglan Zhao; Jun Tang; Hong Wang; Lixia Li; Chen Ding; Xiaoyan Chen; Gaifang Yao; Hua Zhang (Plant Cell Reports, 2021)

Characterization of the complete mitochondrial genome of Macrotocinclus affinis (Siluriformes; Loricariidae) and phylogenetic studies of Siluriformes - Kun Zhang; Yifan Liu; Jian Chen; Hua Zhang; Li Gong; Lihua Jiang; Liqin Liu; Zhenming Lü; Bingjian Liu (Molecular Biology Reports, 2021)

Dynamic development of landslide susceptibility based on slope unit and deep neural networks - Ye Hua; Xianmin Wang; Yongwei Li; Peiyun Xu; Wenxiang Xia (Landslides, 2021)

A plant virus mediates interspecific competition between its insect vectors in Capsicuum annuum - Yong Chen; Xue Zheng; Hui Wei; Yong-Dui Chen; Kuan-Yu Zheng; Ye Mu; Xing-Yue Zhao; Li-Hua Zhao; Yu-Lin Gao; Li-Min Zheng; Jie Zhang (Journal of Pest Science, 2021)

A Fluorogenic and Chromogenic Probe Distinguishes Fluoride Anions and Thiols: Implications for Discrimination of Fluoride-Containing G Series and Sulfur-Containing V Series Nerve Agents - Wei-hui Wu; Xin Wang; Liang Zong; Dan Li; Yan-hua Xiao; Shao-hui Sui; Jian Li; Meng Liu; Gao-yun Chen; Teng Luo; Min Liu; Xin-ming Wang; et al. (Journal of Fluorescence, 2021)

Regulation of glutathione-dependent antioxidant defense system of grass carp Ctenopharyngodon idella under the combined stress of mercury and temperature - Zhi-Hua Li; Ping Li; Yanhua Wu (Environmental Science and Pollution Research, 2021)

Experimental study and constitutive modeling of volume change behavior in unsaturated soils - Wugang Li; Qing Yang; Zhijia Xue; Wenhua Liu; Yuan Hua (Bulletin of Engineering Geology and the Environment, 2021)

A DEM fusion method for ascending and descending orbit StereoSAR DEMs in complicated mountain areas considering SAR echo intensity - Guo-lin Cai; Dong Shen; Ao-li Zhang; Hai-hua Yu; Xuan-yu Zhang (Journal of Mountain Science, 2021)

Paenibacillus turpanensis sp. nov., isolated from a salt lake of Turpan city in Xinjiang province, north-west China - Li Yang; Hua-Wei Huang; Yun Wang; Ya-Rong Kou; Min Yin; Yu Li; Xue-Qian Wang; Gui-Fang Zhao; Wen-Yong Zhu; Shu-Kun Tang (Archives of Microbiology, 2021)

Description of Salinimonas profundi sp. nov., a deep-sea bacterium harboring a transposon Tn6333 - Dao-Feng Zhang; Xi-Wen Cui; Wen-Jun Li; Xiao-Mei Zhang; Hua-Peng Xue; Jian-Ke Huang; Ai-Hua Zhang (Antonie van Leeuwenhoek, 2021)

Phytochemical and antitumor studies on Cynanchum mongolicum (Maxim.) Kom - Yong-Cheng Yang; Yan-Ming Wang; Zi-Jian Rong; Li-Na Hong; Qian Zhang; Jing-Ming Jia; An-Hua Wang (Natural Product Research, 2020)

Design of the Blade under Low Flow Velocity for Horizontal Axis Tidal Current Turbine - Jun-Hua Chen; Xian-Cheng Wang; Hao Li; Chu-Hua Jiang; Ling-Jie Bao (Journal of Marine Science and Engineering, 2020)
The blade is the key component for energy capture in horizontal axis tidal current turbine, and the blade’s design is directly related to the efficiency of the power generation device. The seawater flow velocity is a crucial parameter for blade design. Since the seawater velocity changes constantly, it is extremely important to determine the design velocity of the blade. This article proposes a calculation method for the design velocity of the blade so that the designed blade can achieve better energy collection efficiency under a variable flow velocity. This study performed the following investigations: (1) The author tested and analyzed the seawater velocity variation at the experimental site, determining the designed flow velocity via calculations; (2) The author combined the blade element momentum and Wilson’s optimization design method using the MATLAB software to calculate the blade shape parameters and predict the performance under a number of different flow velocity forecasts; (3) When testing the device under sea conditions, the experimental results showed that the performance capture devices and digital projections are basically the same, which verifies the validity and effectiveness of the design method.

Isolation and characterisation of N-benzyl tadalafil as a novel adulterant in a coffee-based dietary supplement - Pei-Zhi Dong; Xiao-Pu Liu; Lu Zhang; Guo-Hua Shen; Zi-Long Wang; Guo-Wei Yang; Wei Li; Xin-Hua Xiang (Food Additives & Contaminants: Part A, 2020)

Antibody response and therapy in COVID-19 patients: what can be learned for vaccine development? - Ligong Lu; Hui Zhang; Meixiao Zhan; Jun Jiang; Hua Yin; Danielle J. Dauphars; Shi-You Li; Yong Li; You-Wen He (Science China Life Sciences, 2020)

Genomic Analysis for Antioxidant Property of Lactobacillus plantarum FLPL05 from Chinese Longevity People - Xiaomin Yu; Yijuan Li; Qinglong Wu; Nagendra P. Shah; Hua Wei; Feng Xu (Probiotics and Antimicrobial Proteins, 2020)

ADP-ribosylation factors improve biomass yield and salinity tolerance in transgenic switchgrass (Panicum virgatum L.) - Cong Guan; Xue Li; Dan-Yang Tian; Hua-Yue Liu; Hui-Fang Cen; Million Tadege; Yun-Wei Zhang (Plant Cell Reports, 2020)

Etv5 safeguards trophoblast stem cells differentiation from mouse EPSCs by regulating fibroblast growth factor receptor 2 - Kui Zhu; Yuan Liu; Chen Fan; Mengyao Zhang; Hongxia Cao; Xin He; Na Li; Dianfeng Chu; Fang Li; Min Zou; Jinlian Hua; Huayan Wang; et al. (Molecular Biology Reports, 2020)

Fucoxanthin Mitigates Subarachnoid Hemorrhage-Induced Oxidative Damage via Sirtuin 1-Dependent Pathway - Xiang-Sheng Zhang; Yue Lu; Tao Tao; Han Wang; Guang-Jie Liu; Xun-Zhi Liu; Cang Liu; Da-Yong Xia; Chun-Hua Hang; Wei Li (Molecular Neurobiology, 2020)

MicroRNA-217 ameliorates inflammatory damage of endothelial cells induced by oxidized LDL by targeting EGR1 - Xuesong Yang; Dongna Li; Ying-Zi Qi; Wenjing Chen; Chuan-Hua Yang; Yue-Hua Jiang (Molecular and Cellular Biochemistry, 2020)

Straw Incorporation Coupled with Deep Placement of Nitrogen Fertilizer Improved Grain Yield and Nitrogen Use Efficiency in Direct-Seeded Rice - Yunyan Chen; Pingshan Fan; Lin Li; Hua Tian; Umair Ashraf; Zhaowen Mo; Meiyang Duan; Qiantong Wu; Zheng Zhang; Xiangru Tang; Shenggang Pan (Journal of Soil Science and Plant Nutrition, 2020)

Modulatory effect of Tim-3/Galectin-9 axis on T-cell-mediated immunity in pulmonary tuberculosis - Jing Kang; Zhi-Feng Wei; Ming-Xian Li; Jing-Hua Wang (Journal of Biosciences, 2020)

Management of Gout-associated MSU crystals-induced NLRP3 inflammasome activation by procyanidin B2: targeting IL-1β and Cathepsin B in macrophages - Chun-Ying Qiao; Ying Li; Yue Shang; Min Jiang; Jian Liu; Zi-Ying Zhan; Huan Ye; Yong-Ce Lin; Jing-Ya Jiao; Rong-Hui Sun; Zhi-Hong Zhang; Mei-Hua Piao; et al. (Inflammopharmacology, 2020)

Correction to: The effect of teprenone on the intestinal morphology and microbial community of Chinese sea bass (Lateolabrax maculatus) under intermittent hypoxic stress - Hong-biao Dong; Yong-xu Sun; Ya-fei Duan; Hua Li; Yong Li; Qing-song Liu; Wen-hao Wang; Jia-song Zhang (Fish Physiology and Biochemistry, 2020)

Toxicity evaluation of triphenyltin in zebrafish larvae by embryonic malformation, retinal development, and GH/IGF axis - Ping Li; Zhi-Hua Li (Fish Physiology and Biochemistry, 2020)

Association of in-hospital intensive statins dosage and death in arteriosclerotic cardiovascular disease with percutaneous coronary intervention: insights of multicentre cohort from China - Peng-yuan Chen; Yuan-hui Liu; Chong-yang Duan; Hua-lin Fan; Li-huan Zeng; Wei Guo; Lei Jiang; Xue-biao Wei; Wen-fei He; Sha Tao; Zhi-qiang Guo; Ji-yan Chen; et al. (European Journal of Clinical Pharmacology, 2020)

Tributyltin Induces the Tissue-Specific Stresses in Zebrafish, a Study in Various Tissues of Muscle, Gill and Intestine - Ping Li; Zhi-Hua Li (Bulletin of Environmental Contamination and Toxicology, 2020)

Competitive Adsorption and Mobility of Propiconazole and Difenoconazole on Five Different Soils - Feiyan Wang; Duantao Cao; Lihong Shi; Shuhong He; Xin Li; Hua Fang; Yunlong Yu (Bulletin of Environmental Contamination and Toxicology, 2020)

Larger regional volume of the thalamus in diarrhea-predominant irritable bowel syndrome: a cross-sectional study - Cui Ping Mao; Fen Rong Chen; Hong Hong Sun; Mei Juan Shi; Hua Juan Yang; Xiao Hui Li; Dun Ding (Brain Imaging and Behavior, 2020)

The Bre1/Rad6 machinery: writing the central histone ubiquitin mark on H2B and beyond - Zhi-Heng Deng; Hua-Song Ai; Cheng-Piao Lu; Jia-Bin Li (Chromosome Research, 2020)

LncRNA NEAT1 accelerates renal mesangial cell injury via modulating the miR-146b/TRAF6/NF-κB axis in lupus nephritis - Li-Hua Zhang; Bin Xiao; Miao Zhong; Qiao Li; Jian-Ying Chen; Jie-Rou Huang; Hui Rao (Cell and Tissue Research, 2020)

Spatial and Temporal Evolution Characteristics of PM2.5 in China from 1998 to 2016 - Hua Li; Helong Tong; Xianhua Wu; Xiaoli Lu; Shuhan Meng (Chinese Geographical Science, 2020)

Application of multi-component joint inversion in oil and gas exploration: A case study of reservoir and gas saturation prediction of the Xujiahe formation in the PLN area of the central Sichuan Basin - Dong Wang; Zhen-Hua He; Xu-Ben Wang; Le Li; Hai-Tao Yang; Zhi-Guo Fu; Hong-Yan Wang (Applied Geophysics, 2020)

Simulation and verification of an air-gun array wavelet in time-frequency domain based on van der waals gas equation - Dong Zhang; Huai-shan Liu; Lei Xing; Qian-qian Li; Xue-qin Liu; Jia Wei; Jian-hua Wang; Heng Zhou; Xin-min Ge (Applied Geophysics, 2020)

Influence of complex topography on magnetotelluric-observed data using three-dimensional numerical simulation: A case from Guangxi area, China - Xiong Bin; Luo Tian-Ya; Chen Long-Wei; Dai Shi-Kun; Xu Zhi-Feng; Li Chang-Wei; Ding Yan-Li; Wang Hong-Hua; Li Jing-He (Applied Geophysics, 2020)

Sphingosylphosphorylcholine alleviates hypoxia-caused apoptosis in cardiac myofibroblasts via CaM/p38/STAT3 pathway - Ying Li; Qi Qi; Wan-cheng Yang; Tian-liang Zhang; Chen-chen Lu; Yu-juan Yao; Wei-hua Kong; Jing Zhao (Apoptosis, 2020)

Prevalence, Molecular Characterization and Risk Factors of Blastocystis sp. from Farmed Pigs in Yunnan Province, Southwestern China - Jian Qiang Han; Zhao Li; Yang Zou; Li Hua Pu; Xin Quan Zhu; Feng Cai Zou; Cui-Qin Huang (Acta Parasitologica, 2020)

Investigating the abrupt change of tropical cyclone (TC) activity in the Western North Pacific by using different TC genesis indices - Li‐Peng Hsiao; Chih‐Hua Tsou; Jia‐Yuh Yu (International Journal of Climatology, 2020)
The tropical cyclone (TC) genesis indices are used to investigate the abrupt change of TC genesis frequency (TCGF) in the Western North Pacific (WNP) from 1979 to 2014 and to discuss the factors leading to the abrupt change. This study shows that TCGF had an abrupt decrease in 1997, but the popular TC genesis indices used in recent studies do not reflect this feature. An appropriate TC genesis index must consider both thermal and dynamic effects to reflect the TCGF abrupt change in the WNP. We modify the dynamic and thermal effects of the existing indices and propose a new TC genesis index, MoχGPI, which is consistent with the observational abrupt change of TC activity regardless of spatial distribution or time‐series patterns. A budget analysis of MoχGPI is conducted to discuss the individual contribution of large‐scale environmental parameters to the TCGF abrupt change. The results show that the change in relative vorticity (including contributions not only from the environmental relative vorticity, but also a part from the relative vorticity by TCs themself) is the dominant effect leading to the TCGF abrupt change in 1997, followed by the vertical wind shear effect.

Solanrubiellin A, a hydroanthraquinone dimer with antibacterial and cytotoxic activity from Solanum lyratum - Hui Chen; Kun Du; Yan-Jun Sun; Zhi-You Hao; Yan-Li Zhang; Jiang Bai; Qing-Hua Wang; Hai-Yu Hu; Wei-Sheng Feng (Natural Product Research, 2020)

A new demethyl abietane diterpenoid from the roots of Tripterygium wilfordii - Peng Li; Shao-Xin Shen; Ling-Xue Liu; Jian-Hua Xu; Xin-Hua Ma; Dong-Mei Shi; Zhi-Qiang Zhang (Natural Product Research, 2020)

Zircon U-Pb-Hf isotopes and geochemistry of Jurassic igneous rocks from the southern Zhangguangcai Range, NE China: constraints on magmatism, petrogenesis and tectonic implications - Zuo-Zhen Han; Xiang Ren; Hans-Peter Schertl; Xu-Ping Li; Zhi-Gang Song; Qing-Xiang Du; Chao Han; Wen-Jian Zhong; Li-Hua Gao (International Geology Review, 2020)

Determination of phthalate esters in breast milk before and after frozen storage in milk storage bags - Ji-Cai Fan; Ren Ren; Hua-Li He; Quan Jin; Shu-Ting Wang (Food Additives & Contaminants: Part A, 2020)

Interleukin-1β in hypothalamic paraventricular nucleus mediates excitatory renal reflex - Fen Zheng; Chao Ye; Guo-Wei Wan; Bing Zhou; Ying Tong; Jian-Zhen Lei; Qi Chen; Yue-Hua Li; Yu-Ming Kang; Guo-Qing Zhu (Pflügers Archiv - European Journal of Physiology, 2020)

Correction to: Reduced nNOS activity is responsible for impaired fatty acid–dependent mitochondrial oxygen consumption in atrial myocardium from hypertensive rat - Yu Na Wu; Chun Li Jin; Ji Hyun Jang; Zai Hao Zhao; Sung Joon Kim; Yin Hua Zhang (Pflügers Archiv - European Journal of Physiology, 2020)

Reduced nNOS activity is responsible for impaired fatty acid–dependent mitochondrial oxygen consumption in atrial myocardium from hypertensive rat - Yu Na Wu; Chun Li Jin; Ji Hyun Jang; Zai Hao Zhao; Sung Joon Kim; Yin Hua Zhang (Pflügers Archiv - European Journal of Physiology, 2020)

Activation of p62-Keap1-Nrf2 Pathway Protects 6-Hydroxydopamine-Induced Ferroptosis in Dopaminergic Cells - Yiran Sun; Libo He; Taoyu Wang; Wan Hua; Huan Qin; Jingjin Wang; Li Wang; Wanqin Gu; Tingting Li; Na Li; Xinanbei Liu; Fang Chen; et al. (Molecular Neurobiology, 2020)

Effect of various doses of 3,4-dimethylpyrazole phosphate on mineral nitrogen losses in two paddy soils - Hua Li; Xiaodong Chen; Chen Liu; Shaoxian Wang; Bin Guo; Ningyu Li; Yuequn Jin; Qinglin Fu; Xinqiang Liang (Journal of Soils and Sediments, 2020)

Genetic diversity analysis reveals new badnaviruses infecting banana in South China - Xue-Qin Rao; Zi-Lin Wu; Wan Wang; Lin Zhou; Jie Sun; Hua-Ping Li (Journal of Plant Pathology, 2020)

Photosynthetic properties and biochemical metabolism of Cucurbita moschata genotypes following infection with powdery mildew - Bi-Hua Chen; Wei-Li Guo; He-Lian Yang; Qing-Fei Li; Jun-Guo Zhou; Xin-Zheng Li (Journal of Plant Pathology, 2020)
Powdery mildew (PM) is one of the most important fungal diseases in Cucurbita moschata (pumpkin) cultivation. This experiment was conducted to shed light on the physiological mechanisms of PM resistance in pumpkin cultivars. PM pathogen was inoculated on pumpkin seedlings, PM-susceptible genotype (JJJD) and PM-resistant genotype (inbred line 112–2) to study the PM-fungal growth, plant photosynthetic and biochemical parameters with different intervals of time. The disease index and pathogen growth observed for the PM-infected 112–2 seedlings were milder than those observed for the JJJD seedlings. The net photosynthetic rate (Pn), stomatal conductance (gs) and transpiration rate (Tr) were reduced for both the PM-infected genotypes, while the internal CO 2 concentration (Ci) increased in comparison with the non-infected controls. PM pathogen inoculation impaired the photosynthetic performance in seedlings of both genotypes and this was largely associated with stomatal closure. In comparison with the non-infected controls, the superoxide dismutase (SOD) and β-1,3-glucanase activities were reduced for both the PM-infected genotypes, while the peroxidase (POD) and phenylalanine ammonia lyase (PAL) activities were increased. The catalase (CAT) activity was reduced in the 112–2 genotype and increased in the JJJD genotype after PM pathogen inoculation. Together, our data show that PM resistance in pumpkin seedlings is associated with the maintenance of photosynthetic performance and the regulation of defense-related enzyme activities .

Occurrence and light response of residual plastid genes in a Euglena gracilis bleached mutant strain OflB2 - Huan Qin; Qingqing Guo; Chenchen Liu; Fenglan Li; Hua Zhang; Zihan Chu; Jiangxin Wang; Anping Lei (Journal of Oceanology and Limnology, 2020)

Assimilation of exogenous cyanide cross talk in Oryza sativa L. to the key nodes in nitrogen metabolism - Cheng-Zhi Li; Li Yang; Yu-Juan Lin; Hua Zhang; Saeed Rad; Xiao-Zhang Yu (Ecotoxicology, 2020)

Using ecosystem service supply and ecosystem sensitivity to identify landscape ecology security patterns in the Lanzhou-Xining urban agglomeration, China - Hua-li Tong; Pei-ji Shi (Journal of Mountain Science, 2020)

Low‐pressure pipeline irrigation technology in China * - Hua Zhao; Ruoxi Li (Irrigation and Drainage, 2020)
/RÉSUMÉ (ABSTRACT for English and RÉSUMÉ for French) This paper introduces the development of low‐pressure pipeline irrigation technology in China, including relevant technical standards. It illustrates closed, open and semi‐closed pipeline types and provides successful examples of application. It also presents popular pipeline materials, including PE, PVC‐U, PVC‐O, steel reinforced polyethylene and reinforced concrete, as well as their features and range of application. In addition, it discusses problems existing in low‐pressure pipeline irrigation schemes, such as pipeline damage caused by negative pressure, and pipeline blockage resulting from airlocks. © 2020 John Wiley & Sons, Ltd.

A pair of new diastereoisomeric phenylpropanoid-substituted flavan from the leaves of Ilex centrochinensis - Hui Long; Yu Chen; Ze-Hua Hu; Shao-Jun Zhang; Lu-Jun Li (Natural Product Research, 2020)

Applications and research advance of genome shuffling for industrial microbial strains improvement - Liang Chen; Qiu-Hua Xin; Li-Min Ma; Rui-Fang Li; Ke Bian (World Journal of Microbiology and Biotechnology, 2020)

Low Serum Uric Acid Levels Promote Hypertensive Intracerebral Hemorrhage by Disrupting the Smooth Muscle Cell-Elastin Contractile Unit and Upregulating the Erk1/2-MMP Axis - Ning Xiao; Tian-long Liu; Hao Li; Hao-chen Xu; Jing Ge; Hong-yan Wen; Cong-xia Bai; Li Song; Ying-ying Sun; Yin-hui Zhang; Ru-tai Hui; Wei-hua Song; et al. (Translational Stroke Research, 2020)

Evaluation of the Parasitism Capacity of Egg Parasitoid Telenomus dignus on Chilo sacchariphagus - Xue-Hong Pan; Ji-Li Wei; Xian-Kun Shang; Cheng-Hua Huang; Amin Nikpay; François-Régis Goebel (Sugar Tech, 2020)

Response of soybean cyst nematode (Heterodera glycines) and root-knot nematodes (Meloidogyne spp.) to gradients of pH and inorganic salts - Cui Hua; Chunjie Li; Ye Jiang; Minghui Huang; Valerie M. Williamson; Congli Wang (Plant and Soil, 2020)

Somatic embryogenesis in slash pine (Pinus elliottii Engelm): improving initiation of embryogenic tissues and maturation of somatic embryos - Fan Yang; Xin-Rui Xia; Xin Ke; Jianren Ye; Li-hua Zhu (Plant Cell, Tissue and Organ Culture (PCTOC), 2020)

The molecular mechanisms of copper metabolism and its roles in human diseases - Ji Chen; Yunhui Jiang; Hua Shi; Yougong Peng; Xueying Fan; Chenghua Li (Pflügers Archiv - European Journal of Physiology, 2020)

Liquiritin inhibits proliferation and induces apoptosis in HepG2 hepatocellular carcinoma cells via the ROS-mediated MAPK/AKT/NF-κB signaling pathway - Jia-Ru Wang; Tian-Zhu Li; Cheng Wang; Shu-Mei Li; Ying-Hua Luo; Xian-Ji Piao; Yu-Chao Feng; Yi Zhang; Wan-Ting Xu; Yu Zhang; Tong Zhang; Shi-Nong Wang; et al. (Naunyn-Schmiedeberg's Archives of Pharmacology, 2020)

Correction to: Long-Term Oral Toxicity and Anti-osteoporotic Effect of Sintered Dicalcium Pyrophosphate in Rat Model of Postmenopausal Osteoporosis - Yuh-Feng Tsai; Li-Ho Hsu; Chang-Chin Wu; Wei-Hua Cai; Kai-Chiang Yang; Fang-Yu Fan (Journal of Medical and Biological Engineering, 2020)

The effect of teprenone on the intestinal morphology and microbial community of Chinese sea bass (Lateolabrax maculatus) under intermittent hypoxic stress - Hong-biao Dong; Yong-xu Sun; Ya-fei Duan; Hua Li; Yong Li; Qing-song Liu; Wen-hao Wang; Jia-song Zhang (Fish Physiology and Biochemistry, 2020)

Identification, functional characterization, and estrogen regulation on gonadotropin-releasing hormone in the spotted scat, Scatophagus argus - Hua-pu Chen; Xue-fan Cui; Yao-rong Wang; Zhi-yuan Li; Chang-xu Tian; Dong-neng Jiang; Chun-Hua Zhu; Yong Zhang; Shui-sheng Li; Guang-li Li (Fish Physiology and Biochemistry, 2020)

Grape seed proanthocyanidin extract ameliorates hepatic lipid accumulation and inflammation in grass carp (Ctenopharyngodon idella) - Rong-Hua Lu; Chao-Bin Qin; Feng Yang; Wen-Ya Zhang; Yu-Ru Zhang; Guo-Kun Yang; Li-Ping Yang; Xiao-Lin Meng; Xiao Yan; Guo-Xing Nie (Fish Physiology and Biochemistry, 2020)

Complete genome sequence of a distinct isolate of cassava common mosaic virus (CsCMV) infecting cassava in Hainan, China - Nai-tong Yu; Yi Yang; Jun-hua Li; Wei-li Li; Zhi-xin Liu (European Journal of Plant Pathology, 2020)

Phaeotremella camelliae sp. nov. (Phaeotremellaceae, Tremellales), A Novel Yeasts Isolated from Tea-Oil Fruits in Jiangxi Province, China - Yong Sun; Gui-Shuang Wang; Ai-Hua Li; Wangmu; Xian-Qiu Chui; Ji-Hong Jiang; Qi-Ming Wang (Current Microbiology, 2020)

Puerarin Alleviates Lipopolysaccharide-Induced Myocardial Fibrosis by Inhibiting PARP-1 to Prevent HMGB1-Mediated TLR4-NF-κB Signaling Pathway - Shu-Yuan Ni; Xing-Long Zhong; Ze-Hua Li; Dong-Jian Huang; Wen-Ting Xu; Yan Zhou; Cai-Wen Ou; Min-Sheng Chen (Cardiovascular Toxicology, 2020)

Pre-symptomatic local brain activity and functional connectivity alterations in nasopharyngeal carcinoma patients who developed radiation encephalopathy following radiotherapy - You-ming Zhang; Jian-ming Gao; Hong Zhou; Li Li; Li-zhi Liu; Zai-de Han; Xiao-ping Yi; Wei-hua Liao (Brain Imaging and Behavior, 2020)

Comparative iTRAQ Proteomics Reveals Multiple Effects of Selenium Yeast on Dairy Cows in Parturition - Zhi-hua Ren; Li-peng Bai; Liu-hong Shen; Zheng-zhong Luo; Zi-han Zhou; Zhi-cai Zuo; Xiao-ping Ma; Jun-liang Deng; Ya Wang; Sheng-yu Xu; Yu-heng Luo; Sui-zhong Cao; et al. (Biological Trace Element Research, 2020)

Effects of moss-dominated biocrusts on soil detachment by overland flow in the Three Gorges Reservoir Area of China - Guan-hua Zhang; Wen-feng Ding; Jian Pu; Jian-ming Li; Feng Qian; Bao-yang Sun (Journal of Mountain Science, 2020)

Typical gene expression profile of pseudorabies virus reactivation from latency in swine trigeminal ganglion - Hai-Hua Wang; Jie Liu; Lin-Tao Li; Huan-Chun Chen; Wan-Po Zhang; Zheng-Fei Liu (Journal of NeuroVirology, 2020)

Characteristics of the spike and ORF3 genes of porcine epidemic diarrhea virus in Henan and Shanxi provinces of China - Jian-tao Cui; Han Qiao; Cheng-yao Hou; Hui-Hua Zheng; Xin-Sheng Li; Lan-lan Zheng; Hong-Ying Chen (Archives of Virology, 2020)

Sphingomonas hominis sp. nov., isolated from hair of a 21-year-old girl - Dao-Feng Zhang; Xi-Wen Cui; Zhe Zhao; Ai-Hua Zhang; Jian-Ke Huang; Wen-Jun Li (Antonie van Leeuwenhoek, 2020)

Protein extraction and database construction in tea rhizosphere soil - Hai-bin Wang; Chun-lian Zhu; Yu-hua Wang; Qing-xu Zhang; Peng Wang; Ding Li; Xiao-li Jia; Jiang-hua Ye; Hai-bin He (Acta Physiologiae Plantarum, 2020)

The roles of climate, geography and natural selection as drivers of genetic and phenotypic differentiation in a widespread amphibian Hyla annectans (Anura: Hylidae) - Shichao Wei; Zitong Li; Paolo Momigliano; Chao Fu; Hua Wu; Juha Merilä (Molecular Ecology, 2020)
The role of geological events and Pleistocene climatic fluctuations as drivers of current patterns of genetic variation in extant species has been a topic of continued interest among evolutionary biologists. Nevertheless, comprehensive studies of widely distributed species are still rare, especially from Asia. Using geographically extensive sampling of many individuals and a large number of nuclear single nucleotide polymorphisms (SNPs), we studied the phylogeography and historical demography of Hyla annectans populations in southern China. Thirty‐five sampled populations were grouped into seven clearly defined genetic clusters that closely match phenotype‐based subspecies classification. These lineages diverged 2.32–5.23 million years ago (Ma), a timing that closely aligns with the rapid and drastic uplifting of the Qinghai‐Tibet Plateau and adjacent southwest China. Demographic analyses and species distribution models indicate that different populations of this species have responded differently to past climatic changes. In the Hengduan Mountains, most populations experienced a bottleneck, whereas the populations located outside of the Hengduan Mountains have gradually declined in size since the end of the last glaciation. In addition, the levels of phenotypic and genetic divergence were strongly correlated across major clades. These results highlight the combined effects of geological events and past climatic fluctuations, as well as natural selection, as drivers of contemporary patterns of genetic and phenotypic variation in a widely distributed anuran in Asia.

Noise does not equal bias in assessing the evolutionary history of the angiosperm flora of China: A response to Qian (2019) - Li‐Min Lu; Hai‐Hua Hu; Dan‐Xiao Peng; Bing Liu; Jian‐Fei Ye; Tuo Yang; Hong‐Lei Li; Miao Sun; Stephen A. Smith; Pamela S. Soltis; Douglas E. Soltis; Zhi‐Duan Chen (Journal of Biogeography, 2020)
In response to our paper on the evolutionary history of the Chinese flora, Qian suggests that certain features of the divergence time estimation employed might have led to biased conclusions in Lu et al (2018). Here, we consider Qian's specific criticisms, explore the extent of uncertainty in the data and demonstrate that (i) no systematic bias toward dates that are too young or too old is detected in Lu et al.; (ii) constraint of the crown age of angiosperms does not bias the generic ages estimated by Lu et al.; and (iii) ages derived from the Chinese regional phylogeny do not bias the conclusions reported by Lu et al. All these analyses confirm that the conclusions reported previously are robust. We argue that, like many large‐scale biodiversity analyses, sources of noise in divergence time estimation are to be expected, but these should not be confused with bias.

Cytotoxic triquinane-type sesquiterpenoids from the endophytic fungus Cerrena sp. A593 - Hong-Xin Liu; Hai-Bo Tan; Yu-Chan Chen; Sai-Ni Li; Hao-Hua Li; Wei-Min Zhang (Natural Product Research, 2020)