Retraction Note to: Revisiting the male genetic landscape of China: a multi-center study of almost 38,000 Y-STR haplotypes - Michael Nothnagel; Guangyao Fan; Fei Guo; Yongfeng He; Yiping Hou; Shengping Hu; Jiang Huang; Xianhua Jiang; Wook Kim; Kicheol Kim; Chengtao Li; Hui Li; et al. (Human Genetics, 2022)

Effects of soil cadmium exposure on physio-ecological characteristics of Bletilla striata - Qin Xu; Jihong Qin; Hui Sun; Xiaoqin Wang; Wenqing Chen; Zhi Li (Environmental Science and Pollution Research, 2022)

Study on metal binding capacity of the freshwater crab Sinopotamon henanense’s recombinant copper specific binding metallothionein expressed in Escherichia coli - Lu Wang; Hui Zhen Yang; Wen Li Ma; Chien Min Chen; Lan Wang (Ecotoxicology, 2022)

Deinococcus aestuarii sp. nov. and Deinococcus aquaedulcis sp. nov., two novel resistant bacteria isolated from pearl river estuary - Ling-Zi Yin; Jia-Ling Li; Ze-Tao Liu; Bao-Zhu Fang; Pandeng Wang; Xiao-Qing Luo; Lei Dong; Li Duan; Shan-Hui Li; Wen-Jun Li (Antonie van Leeuwenhoek, 2022)

Biogeography of culturable marine bacteria from both poles reveals that ‘everything is not everywhere’ at the genomic level - Qi‐Long Qin; Zhi‐Bin Wang; Qian‐Qian Cha; Sha‐Sha Liu; Xue‐Bing Ren; Hui‐Hui Fu; Mei‐Ling Sun; Dian‐Li Zhao; Andrew McMinn; Yin Chen; Xiu‐Lan Chen; Yu‐Zhong Zhang; et al. (Environmental Microbiology, 2022)
Summary Based on 16S rRNA gene analyses, the same bacterial operational taxonomic units (OTUs) are common to both the Arctic and Antarctic oceans, supporting the concept ‘everything is everywhere’. However, whether the same OTUs from both poles have identical genomes, i.e. whether ‘everything is still everywhere’ at the genomic level has not yet been examined systematically. Here, we isolated, sequenced and compared the genomes of 45 culturable marine bacteria belonging to three genera of Salinibacterium , Psychrobacter and Pseudoalteromonas from both polar oceans. The bacterial strains with identical 16S rRNA genes were common to both poles in every genus, and four identical genomes were detected in the genus Salinibacterium from the Arctic region. However, no identical genomes were observed from opposite poles in this study. Our data, therefore, suggest that ‘everything is not everywhere’ at the genomic level. The divergence time between bacteria is hypothesized to exert a strong impact on the bacterial biogeography at the genomic level. The geographical isolation between poles was observed for recently diverged, highly similar genomes, but not for moderately similar genomes. This study thus improves our understanding of the factors affecting the genomic‐level biogeography of marine microorganisms isolated from distant locations.

Adsorption of BDE-209 to Polyethylene Microplastics: Effect of Microplastics Property and Metal Ions - Yanfeng Zhu; Xiaoxiao Li; Liping Wang; Nan Hui; Jing Ma; Fu Chen (Water, Air, & Soil Pollution, 2021)

The Key Regulator of Necroptosis, RIP1 Kinase, Contributes to the Formation of Astrogliosis and Glial Scar in Ischemic Stroke - Yong-Ming Zhu; Liang Lin; Chao Wei; Yi Guo; Yuan Qin; Zhong-Sheng Li; Thomas A. Kent; Claire E. McCoy; Zhan-Xiang Wang; Yong Ni; Xian-Yong Zhou; Hui-Ling Zhang (Translational Stroke Research, 2021)
Necroptosis initiation relies on the receptor-interacting protein 1 kinase (RIP1K). We recently reported that genetic and pharmacological inhibition of RIP1K produces protection against ischemic stroke-induced astrocytic injury. However, the role of RIP1K in ischemic stroke-induced formation of astrogliosis and glial scar remains unknown. Here, in a transient middle cerebral artery occlusion (tMCAO) rat model and an oxygen and glucose deprivation and reoxygenation (OGD/Re)-induced astrocytic injury model, we show that RIP1K was significantly elevated in the reactive astrocytes. Knockdown of RIP1K or delayed administration of RIP1K inhibitor Nec-1 down-regulated the glial scar markers, improved ischemic stroke-induced necrotic morphology and neurologic deficits, and reduced the volume of brain atrophy. Moreover, knockdown of RIP1K attenuated astrocytic cell death and proliferation and promoted neuronal axonal generation in a neuron and astrocyte co-culture system. Both vascular endothelial growth factor D (VEGF-D) and its receptor VEGFR-3 were elevated in the reactive astrocytes; simultaneously, VEGF-D was increased in the medium of astrocytes exposed to OGD/Re. Knockdown of RIP1K down-regulated VEGF-D gene and protein levels in the reactive astrocytes. Treatment with 400 ng/ml recombinant VEGF-D induced the formation of glial scar; conversely, the inhibitor of VEGFR-3 suppressed OGD/Re-induced glial scar formation. RIP3K and MLKL may be involved in glial scar formation. Taken together, these results suggest that RIP1K participates in the formation of astrogliosis and glial scar via impairment of normal astrocyte responses and enhancing the astrocytic VEGF-D/VEGFR-3 signaling pathways. Inhibition of RIP1K promotes the brain functional recovery partially via suppressing the formation of astrogliosis and glial scar. Graphical Abstract

Experimental Study on the Response Characteristics of the Apparent Resistivity of Rock True Triaxial Hydraulic Fracturing - Nan Li; Manyue Yan; Hui Zhao; Peng Chen; Chao Cai; Enyuan Wang; Zhihuai Li (Natural Resources Research, 2021)

Correction to: μ-Opioid Receptor–Mediated Enteric Glial Activation Is Involved in Morphine-Induced Constipation - Hui Gao; Yuxin Zhang; Yansong Li; Haiqing Chang; Bo Cheng; Na Li; Wei Yuan; Shuang Li; Qiang Wang (Molecular Neurobiology, 2021)

Predicting circRNA-Disease Associations Based on Deep Matrix Factorization with Multi-source Fusion - Guobo Xie; Hui Chen; Yuping Sun; Guosheng Gu; Zhiyi Lin; Weiming Wang; Jianming Li (Interdisciplinary Sciences: Computational Life Sciences, 2021)

Occurrence, source apportionment, and carcinogenic risk assessment of polycyclic aromatic hydrocarbons in urban road dusts in Shanghai - Xue-Tong Wang; Rui Fu; Ying Zhou; Cheng-Lin Wang; Guo-Fa Ren; Xiao-Li Wang; Hui Li (Environmental Science and Pollution Research, 2021)

Detoxification difference of cadmium between the application of selenate and selenite in native cadmium-contaminated soil - Mingxing Qi; Yang Liu; Yanan Li; Min Wang; Nana Liu; Pornpimol Kleawsampanjai; Fei Zhou; Hui Zhai; Mengke Wang; Quang Toan Dinh; Rui Ren; Dongli Liang (Environmental Science and Pollution Research, 2021)

Australian propolis ethanol extract exerts antibacterial activity against methicillin-resistant Staphylococcus aureus by mechanisms of disrupting cell structure, reversing resistance, and resisting biofilm - Fei Wang; Hui Liu; Junya Li; Wenwen Zhang; Bin Jiang; Hongzhuan Xuan (Brazilian Journal of Microbiology, 2021)

Enhanced expression of DNA methyltransferase 1-associated protein1 gene thermotolerance in a high-temperature acclimated predatory mite Neoseiulus barkeri - Ya-Ying Li; Chuan-Bei Tian; Yi-Xia Wu; Tian-Di Niu; Hao Wang; Wen-Hui Fan; Huai Liu (BioControl, 2021)

The first third-generation HIV-1 circulating recombinant form (CRF114_0155) identified in central China - Yang Li; Yan Zhang; Hongye Wang; Long Liu; Hui Chen; Shuanhu Zhang; Wenying Wu; Rongge Yang (Archives of Virology, 2021)

Assessment of probiotic adhesion and inhibitory effect on Escherichia coli and Salmonella adhesion - Ya Wang; Dan Jia; Jia-hui Wang; He-hai Li; Jun-long Liu; Ai-hong Liu; Jin-ming Wang; Gui-quan Guan; Jian-xun Luo; Hong Yin; You-quan Li (Archives of Microbiology, 2021)

Radial velocity of ocean surface current estimated from SAR Doppler frequency measurements—a case study of Kuroshio in the East China Sea - Lihua Wang; Benwei Shi; Yunxuan Zhou; Hui Sheng; Yanghua Gao; Li Fan; Ziheng Yang (Acta Oceanologica Sinica, 2021)

Differential effects of altered precipitation regimes on soil carbon cycles in arid versus humid terrestrial ecosystems - Bin Wang; Yali Chen; Yan Li; Hui Zhang; Kai Yue; Xingchang Wang; Yuandan Ma; Jian Chen; Meng Sun; Zhuo Chen; Qiqian Wu (Global Change Biology, 2021)
Changes in precipitation regimes have significant effects on soil carbon (C) cycles; however, these effects may vary in arid versus humid areas. Additionally, the corresponding details of soil C cycles in response to altered precipitation regimes have not been well documented. Here, a meta‐analysis was performed using 845 pairwise observations (control vs. increased or decreased precipitation) from 214 published articles to quantify the responses of the input process of exogenous C, the contents of various forms of C in soil, and the soil‐atmosphere C fluxes relative to increased or decreased precipitation. The results showed that the effects of altered precipitation regimes did not differ between rainfall and snowfall. Increased precipitation significantly enhanced the soil C inputs, pools and outputs by 18.17%, 18.50%, and 21.04%, respectively, while decreased precipitation led to a significant decline in these soil C parameters by 10.18%, 9.96%, and 17.98%, respectively. The effects of increased precipitation on soil C cycles were more significant in arid areas (where mean annual precipitation, MAP

Theoretical and Numerical Analysis of Blasting Pressure of Cylindrical Shells under Internal Explosive Loading - Zhan-Feng Chen; Hui-Jie Wang; Zhiqian Sang; Wen Wang; He Yang; Wei-Ming Meng; Yu-Xing Li (Journal of Marine Science and Engineering, 2021)
Cylindrical shells are principal structural elements that are used for many purposes, such as offshore, sub-marine, and airborne structures. The nonlinear mechanics model of internal blast loading was established to predict the dynamic blast pressure of cylindrical shells. However, due to the complexity of the nonlinear mechanical model, the solution process is time-consuming. In this study, the nonlinear mechanics model of internal blast loading is linearized, and the dynamic blast pressure of cylindrical shells is solved. First, a mechanical model of cylindrical shells subjected to internal blast loading is proposed. To simplify the calculation, the internal blast loading is reduced to linearly uniform variations. Second, according to the stress function method, the dynamic blast pressure equation of cylindrical shells subjected to blast loading is derived. Third, the calculated results are compared with those of the finite element method (FEM) under different durations of dynamic pressure pulse. Finally, to reduce the errors, the dynamic blast pressure equation is further optimized. The results demonstrate that the optimized equation is in good agreement with the FEM, and is feasible to linearize the internal blast loading of cylindrical shells.

Microplastics in Mollusks: Research Progress, Current Contamination Status, Analysis Approaches, and Future Perspectives - Ruixuan Wang; Hongli Mou; Xiaozhi Lin; Hui Zhu; Bing Li; Jiangyong Wang; Muhammad Junaid; Jun Wang (Frontiers in Marine Science, 2021)
Plastic fragments < 5 mm, known as microplastics (MPs), are ubiquitously present in the marine environment. Research on MPs pollution has gradually shifted from field investigations to laboratory studies. With the rapid growth of plastic consumption and the prevalence of aquaculture products, studies on marine MPs have focused on key marine species, such as mollusks. This review summarizes the recent knowledge including 77 important relevant literatures (from 2010 to 2021) on MPs contamination in mollusks with the objectives of (1) elucidating the current status of MPs pollution levels in mollusks, (2) highlighting the main methods and techniques for separation, extraction, and identification of MPs in soft tissues of bivalves and (3) presenting the current research progress and future directions. The review visually presents some of the important results in graphic form, which shows that the most common polymer plastics in bivalves are polypropylene, polystyrene, and polyethylene, and the shapes were mainly fiber and threadiness, mollusks are more likely to feed smaller MPs, most of the MPs in bivalves are less than 500 μm, and the abundance of MPs in seawater and the abundance of MPs in mollusks have a positive relationship, etc. This review will provide a comprehensive reference for studies of microplastics in marine organisms and the ecological pollution, and also has scientific guiding significance in the research method.

Cytotoxic triterpenoid glycosides from leaves of Cyclocarya paliurus - Hui-Hui Sun; Wen-Yan Lv; Jie Tan; Yu-Cheng Tang; Hui Zhu; Jian-Bo Qu; Jing Li; Jian-Ping Wu; Xi-Wen Chang; Zhi-Chun Yang; Wen-Xuan Wang; Zu-Hui Chen; et al. (Natural Product Research, 2021)

Characteristics of patients with ST-segment elevated myocardial infarction (STEMI) at the initial stage of the COVID-19 pandemic: a systematic review and meta-analysis - Yuhang Zhu; Wanying Xing; Hui Wang; Jun Song; Zhixia Sun; Xingzhao Li (Infectious Diseases, 2021)

Removal of roosters alters the domestic phenotype and microbial and genetic profile of hens - Hai Xiang; Siyu Chen; Hui Zhang; Xu Zhu; Dan Wang; Huagui Liu; Jikun Wang; Tao Yin; Langqing Liu; Minghua Kong; Jian Zhang; Hua Li; et al. (Science China Life Sciences, 2021)

TLR2 Potentiates SR-Marco-Mediated Neuroinflammation by Interacting with the SRCR Domain - Lu Wang; Han-Yu Yang; Cai-Xia Zang; Jun-Mei Shang; Hui Liu; Zi-Hong Zhang; Fang-Yu Yuan; Cheng Ju; Fang-Yuan Li; Xiu-Qi Bao; Dan Zhang (Molecular Neurobiology, 2021)

Hydrological characteristics and changes in the Nu-Salween River basin revealed with model-based reconstructed data - Fan Yang; Hui Lu; Kun Yang; Guang-wei Huang; Yi-shan Li; Wei Wang; Ping Lu; Fu-qiang Tian; Yu-gang Huang (Journal of Mountain Science, 2021)

Simulation of indoor cigarette smoke particles in a ventilated room - Yunfei Song; Quan Yang; Hui Li; Shengnan Shen; Hongbin Chen; Yicang Huang; Guoqing Zhang; Jiayue Wang; Wei Wei (Air Quality, Atmosphere & Health, 2021)

Recent improvements to the physical model of the Bohai Sea, the Yellow Sea and the East China Sea Operational Oceanography Forecasting System - Ang Li; Xueming Zhu; Yunfei Zhang; Shihe Ren; Miaoyin Zhang; Ziqing Zu; Hui Wang (Acta Oceanologica Sinica, 2021)

A new ergostane derivative from the leaves of Heynea trijuga Roxburgh - Shou-Bai Liu; Zheng Cui; Hui-Qin Chen; Hao Wang; Wen-Hua Dong; Cai-Hong Cai; Wen-Li Mei; Hao-Fu Dai (Natural Product Research, 2021)

Pleosporalins H and I, two new heptaketides from the endophytic fungus Pleosporales sp. F46 by using OSMAC strategy - Hong-Xia Yang; Xiao-Ping Peng; Han Gao; Hui-Min Zhang; Zi-Ru Wang; Gang Li; Hong-Xiang Lou (Natural Product Research, 2021)

Genetic and molecular characterization of determinant of six-rowed spike of barley carrying vrs1.a4 - Jin-Hui Wang; Zhen-Mei Xu; Xue-Bing Qiu; Li-Lan Li; Shui-Yang Yu; Tao Li; Yan-Yan Tang; Xi Pu; Juan-Yu Zhang; Hai-Li Zhang; Jun-Jun Liang; Ya-Wei Tang; et al. (Theoretical and Applied Genetics, 2021)

Peripheral CD4+ T cell signatures in predicting the responses to anti-PD-1/PD-L1 monotherapy for Chinese advanced non-small cell lung cancer - Liliang Xia; Hui Wang; Mingjiao Sun; Yi Yang; Chengcheng Yao; Sheng He; Huangqi Duan; Weimin Xia; Ruiming Sun; Yaxian Yao; Zhiwei Chen; Qiong Zhao; et al. (Science China Life Sciences, 2021)

Pseudotime Ordering Single-Cell Transcriptomic of β Cells Pancreatic Islets in Health and Type 2 Diabetes - Kaixuan Bao; Zhicheng Cui; Hui Wang; Hui Xiao; Ting Li; Xingxing Kong; Tiemin Liu (Phenomics, 2021)

Recent advances in the role of Th17/Treg cells in tumor immunity and tumor therapy - Yin Qianmei; Su Zehong; Wang Guang; Li Hui; Gaojian Lian (Immunologic Research, 2021)

Resting-state abnormalities in functional connectivity of the default mode network in autism spectrum disorder: a meta-analysis - Qing Wang; Hua-Yun Li; Yun-Da Li; Ya-Ting Lv; Hui-Bin Ma; An-Feng Xiang; Xi-Ze Jia; Dong-Qiang Liu (Brain Imaging and Behavior, 2021)

An Investigation of Toxic Metal Levels (Pb, Cd, Cr, As, Hg) in Dried Porphyra and Laminaria Collected from Coastal Cities, China - Yan Chen; Yong-tao Liu; Fu-hua Wang; Dian Wen; Hui Yang; Xiao-li Zhao (Biological Trace Element Research, 2021)

Whole-exome sequencing identified a novel mutation in CHM of a Chinese family - Hui Tang; Jun Mao; Jingjing Xiang; Minjuan Liu; Haibo Li; Ting Wang (Journal of Genetics, 2021)

1H NMR-based assay for lysine demethylase LSD1 and its application to inhibitor screening - Hui Wang; Minghui Shu; Xiaofan Li; Wei-Guo Zhu; He Wen; Zebin Mao (Genome Instability & Disease, 2021)

A new indole alkaloid with HUVEC proliferation activities from Nauclea officinalis - Shi-Ying Mai; Yong-Hui Li; Xu-Guang Zhang; Yi-Ran Wang; Jun-Qing Zhang; An Jia (Natural Product Research, 2021)

Genetic control and phenotypic characterization of panicle architecture and grain yield-related traits in foxtail millet (Setaria italica) - Hui Zhi; Qiang He; Sha Tang; Junjun Yang; Wei Zhang; Huifang Liu; Yanchao Jia; Guanqing Jia; Aiying Zhang; Yuhui Li; Erhu Guo; Ming Gao; et al. (Theoretical and Applied Genetics, 2021)

Transcriptome Sequencing of a Novel Albino Mutant of Hexaploid Sweetpotato - Mohamed Hamed Arisha; Yan Hui; Muhammad Qadir Ahmad; Tang Wei; Kou Meng; Liu Yaju; Wang Xin; Zhang Yungang; Li Qiang (Plant Molecular Biology Reporter, 2021)

A Frameshift Variant in the SEMA6B Gene Causes Global Developmental Delay and Febrile Seizures - Li Shu; Yuchen Xu; Qi Tian; Yuanyuan Chen; Yaqin Wang; Hui Xi; Hua Wang; Neng Xiao; Xiao Mao (Neuroscience Bulletin, 2021)

Experimental investigation on synergetic prediction of rockburst using the dominant-frequency entropy of acoustic emission - Chunlai Wang; Cong Cao; Yubo Liu; Changfeng Li; Guangyong Li; Hui Lu (Natural Hazards, 2021)

BDNF Participates in Chronic Constriction Injury-Induced Neuropathic Pain via Transcriptionally Activating P2X7 in Primary Sensory Neurons - Yi Wu; Zhiwen Shen; Hui Xu; Kun Zhang; Mingyan Guo; Fei Wang; Junhua Li (Molecular Neurobiology, 2021)

A review of possible therapies for multiple sclerosis - Hui Li; Gaojian Lian; Guang Wang; Qianmei Yin; Zehong Su (Molecular and Cellular Biochemistry, 2021)

Human Amniotic Epithelial Cells Alleviate a Mouse Model of Parkinson’s Disease Mainly by Neuroprotective, Anti-Oxidative and Anti-Inflammatory Factors - Jiaofei Zhang; Hui Li; Hao Yang; Jianhua Lin; You Wang; Qianjun Zhang; Wei-Qiang Gao; Huiming Xu (Journal of Neuroimmune Pharmacology, 2021)

Syntheses, Structures and Luminescent Properties of Eu- and Tb-MOFs with 3,5-Pyridinedicarboxylate and 1,2-Benzenedicarboxylate - Hongsheng Wang; Shichao Wang; Hui Li; Xinhua Chen (Journal of Fluorescence, 2021)

Polystyrene microplastics induce blood–testis barrier disruption regulated by the MAPK-Nrf2 signaling pathway in rats - Shengda Li; Qimeng Wang; Hui Yu; Long Yang; Yiqing Sun; Ning Xu; Nana Wang; Zhimin Lei; Junyu Hou; Yinchuan Jin; Hongqin Zhang; Lianqin Li; et al. (Environmental Science and Pollution Research, 2021)

Characteristics of tailpipe volatile halogenated hydrocarbon (VHC) emissions from in-use vehicles during real-world driving - Hui Mei; Menglei Wang; Boqiang Jin; Rencheng Zhu; Yunjing Wang; Lulu Wang; Shunyi Li; Ruiqin Zhang; Xiaofeng Bao (Environmental Science and Pollution Research, 2021)

Combined use of lime, bentonite, and biochar for immobilization of Cd and mobilization of Se in paddy soil - Zhiqiang Xu; Bin Liang; Zhonghui Li; Hui Jiang; Ting Liu; Qiubo Wang; Jiaxin Duan (Environmental Science and Pollution Research, 2021)

Effects of Vegetation Restoration on Soil Enzyme Activity in Copper and Coal Mining Areas - Hui Sun; Jianfeng Zhang; Rongjia Wang; Zongtai Li; Shiyong Sun; Guanghua Qin; Yumin Song (Environmental Management, 2021)

Biodegradation of Di-n-butyl phthalate in rhizosphere and growth-promoting effect of Cucumis sativus Linn. by a novel Pseudomonas sp. DNB-S1 - Shuqin Li; Lei Wang; Ying Li; Fuxin Huang; Hui Yu; Ying Zhang; Rui Li; Zhaobo Chen; Ningrui Wei; Zhengzhe Yu (Ecotoxicology, 2021)

Methane Concentration in the Heartwood of Living Trees and Estimated Methane Emission on Stems in Upland Forests - Zhi-Ping Wang; Huan-Long Li; Hong-Hui Wu; Shi-Jie Han; Jian-Hui Huang; Xi-Mei Zhang; Xing-Guo Han (Ecosystems, 2021)

Antibacterial effect of Blumea balsamifera (L.) DC. essential oil against Staphylococcus aureus - Hui Yang; Yue Gao; Li Long; Yalin Cai; Jiamei Liao; Junchao Peng; Lu Wang (Archives of Microbiology, 2021)

The Significant Role of Radiosonde-measured Cloud-base Height in the Estimation of Cloud Radiative Forcing - Hui Xu; Jianping Guo; Jian Li; Lin Liu; Tianmeng Chen; Xiaoran Guo; Yanmin Lyu; Ding Wang; Yi Han; Qi Chen; Yong Zhang (Advances in Atmospheric Sciences, 2021)

Mesozoic intracontinental deformation of the Alxa Block in the middle part of Central Asian Orogenic Belt: A review - Jin Zhang; Yannan Wang; Junfeng Qu; Beihang Zhang; Heng Zhao; Long Yun; Tianyi Li; Pengfei Niu; Fengjun Nie; Jie Hui; Yiping Zhang (International Geology Review, 2021)

CsKTN1 for a katanin p60 subunit is associated with the regulation of fruit elongation in cucumber (Cucumis sativus L.) - Hui Wang; Jing Sun; Fan Yang; Yiqun Weng; Peng Chen; Shengli Du; Aimin Wei; Yuhong Li (Theoretical and Applied Genetics, 2021)

Alpha-Lipoic Acid Attenuates Cadmium- and Lead-Induced Neurotoxicity by Inhibiting Both Endoplasmic-Reticulum Stress and Activation of Fas/FasL and Mitochondrial Apoptotic Pathways in Rat Cerebral Cortex - Yan Yuan; Shi Wen Zhao; Shuang Quan Wen; Qiao Ping Zhu; Li Wang; Hui Zou; Jian Hong Gu; Xue Zhong Liu; Jian Chun Bian; Zong Ping Liu (Neurotoxicity Research, 2021)

Upregulated SOCC and IP3R calcium channels and subsequent elevated cytoplasmic calcium signaling promote nonalcoholic fatty liver disease by inhibiting autophagy - Lin Zhang; Yifan Zhang; Yuanqing Jiang; Xiaobing Dou; Songtao Li; Hui Chai; Qianyu Qian; Miaojuan Wang (Molecular and Cellular Biochemistry, 2021)

Three Paralogous R2R3-MYB Genes Contribute to Delphinidin-Related Anthocyanins Synthesis in Petunia hybrida - Zhenzhu Fu; Hui Jiang; Yacong Chao; Xiaoyu Dong; Xin Yuan; Limin Wang; Jing Zhang; Menglan Xu; Huijuan Wang; Yanmin Li; Jie Gao; Hechen Zhang (Journal of Plant Growth Regulation, 2021)

Resource status and protection strategies of mangroves in China - Xiu-Mei Fu; Hui-Ying Tang; Yang Liu; Meng-Qi Zhang; Shan-Shan Jiang; Fang Yang; Xiao-Yan Li; Chang-Yun Wang (Journal of Coastal Conservation, 2021)
Mangrove is a typical natural landscape with great ecological, social and economic functions and values, and should be highly valued and protected. However, in the past few decades, mangrove resources have suffered serious damage, and there are also many deficiencies in mangrove protection. Chinese mangroves, as an important part of the global mangroves, are of great research value. In the present study, the status and historical dynamic process of Chinese mangrove resources were investigated and discussed to illustrate the problems of resources from three aspects, including mangrove distribution, area and plant species. Based on field research, literature research and data analysis, it was revealed that Chinese mangroves are distributed in eight provinces and regions along the southeast coast with an area of 35,749.25 hm 2 , 38 species and 40 nature reserves. The protection situation and deficiencies were analyzed from the establishment and management of nature reserves. Based on the resource status and problems, reasonable strategies were proposed to protect and manage mangroves mainly from four aspects, including publicity and education, resources restoration and protection technology, legal system establishment, and comprehensive protection and management.

Preparation of Fe-MIL(100)-encapsulated magnetic g-C3N4 for adsorption of PPCPs from aqueous solution - Yuting Wang; Liyan He; Guoyan Dang; Hui Li; Xiaoli Li (Environmental Science and Pollution Research, 2021)

A novel index of functional connectivity: phase lag based on Wilcoxon signed rank test - Xuan Li; Yunqiao Wu; Mengting Wei; Yiyun Guo; Zhenhua Yu; Haixian Wang; Zhanli Li; Hui Fan (Cognitive Neurodynamics, 2021)

Abnormal brain activity patterns during spatial working memory task in patients with end-stage renal disease on maintenance hemodialysis: a fMRI study - Jinzhuang Huang; Lei Xie; Ruiwei Guo; Jinhong Wang; Jinquan Lin; Zongbo Sun; Shouxing Duan; Zhirong Lin; Hui Li; Shuhua Ma (Brain Imaging and Behavior, 2021)
Hemodialysis (HD) is associated with cognitive impairment in patients with end-stage renal disease (ESRD). However, the neural mechanism of spatial working memory (SWM) impairment in HD-ESRD patients remains unclear. We investigated the abnormal alterations in SWM-associated brain activity patterns in HD-ESRD patients using blood oxygen level-dependent functional magnetic resonance imaging (BOLD-fMRI) technique during n-back tasks. Twenty-two HD-ESRD patients and 22 well-matched controls underwent an fMRI scan while undergoing a three-load n-back tasks with different difficulty levels. Cognitive and mental states were assessed using a battery of neuropsychologic tests. The HD-ESRD patients exhibited worse memory abilities than controls. Compared with the control group, the HD-ESRD patient group showed lower accuracy and longer response time under the n-back tasks, especially in the 2-back task. The patterns of brain activation changed under different working memory loads in the HD-ESRD patients, showing decreased activity in the right medial frontal gyrus and inferior frontal gyrus under 0-back and 1-back task, while more decreased activation in the bilateral frontal cortex, parietal lobule, anterior/posterior cingulate cortex and insula cortex under 2-back task. With the increase of task difficulty, the activation degree of the frontal and parietal cortex decreased. More importantly, we found that lower activation in frontal cortex and parietal lobule was associated with worse cognitive function in the HD-ESRD patients. These results demonstrate that the abnormal brain activity patterns of frontal cortex and parietal lobule may reflect the neural mediation of SWM impairment.

Flexible reconfiguration of functional brain networks as a potential neural mechanism of creativity - Junchao Li; Natasza Orlov; Zengjian Wang; Bingqing Jiao; Yibo Wang; Huawei Xu; Hui Yang; Yingying Huang; Yan Sun; Peng Zhang; Rengui Yu; Ming Liu; et al. (Brain Imaging and Behavior, 2021)

OSL chronology of a Palaeolithic site in a humid subtropical mountainous area of southeast China - Jian-hui Jin; Xiao-yang Wang; Zhen-yu Zhou; Yun-ming Huang; Xue-chun Fan; Xin-xin Zuo; Zhi-zhong Li; Zhi-yong Ling; Yong-qing Ren; Shu-tong Li (Journal of Mountain Science, 2021)

Transcriptome analysis reveals hub genes in the hepatopancreas of Exopalaemon carinicauda in response to hypoxia and reoxygenation - Wenjun Shi; Pan Wang; Runhao Hu; Xihe Wan; Hui Shen; Hui Li; Libao Wang; Yi Qiao; Ge Jiang; Jie Cheng; Zeyu Yang (Aquaculture International, 2021)

Three new 5,6,7,8-tetrahydro-2-(2-phenylethyl)chromones and one new dimeric 2-(2-phenylethyl)chromone from agarwood of Aquilaria crassna Pierre ex Lecomte in Laos - Yang-Mei Zhao; Li Yang; Fan-Dong Kong; Wen-Hua Dong; Wei Li; Hui-Qin Chen; Hao Wang; Cai-Hong Cai; Cui-Juan Gai; Wen-Li Mei; Hao-Fu Dai (Natural Product Research, 2021)

A new epimer of azaphilone derivative pinophilin B from the gorgonian-derived fungus Aspergillus fumigatus 14–27 - Ya-Hui Zhang; Xiao-Yue Peng; Li-Xi Feng; Hua-Jie Zhu; Fei Cao; Chang-Yun Wang (Natural Product Research, 2021)

Two new flavonoid glucosides from the fruits of Sinopodophyllum hexandrum - Yan-Jun Sun; Hao-Jie Chen; Gui-Min Xue; Hui Chen; Yan-Li Zhang; Meng Li; Kun Du; Jun-Min Wang; Wei-Sheng Feng (Natural Product Research, 2021)

Transcriptome analysis of differentially expressed genes in chrysanthemum MET1 RNA interference lines - Dong-ru Kang; Yi Zhu; Shuai-lei Li; Peng-hui Ai; Muhammad Ayoub Khan; Hong-xu Ding; Ying Wang; Zi-cheng Wang (Physiology and Molecular Biology of Plants, 2021)

μ-Opioid Receptor–Mediated Enteric Glial Activation Is Involved in Morphine-Induced Constipation - Hui Gao; Yuxin Zhang; Yansong Li; Haiqing Chang; Bo Cheng; Na Li; Wei Yuan; Shuang Li; Qiang Wang (Molecular Neurobiology, 2021)

The effect of land use change and soil redistribution on soil organic carbon dynamics in karst graben basin of China - Gaoyong Lan; Chun Liu; Hua Wang; Wei Tang; Xia Wu; Hui Yang; Linling Tu; Bill X. Hu; Jianhua Cao; Qiang Li (Journal of Soils and Sediments, 2021)

The effect of long-term freeze-thaw cycles on the stabilization of lead in compound solidified/stabilized lead-contaminated soil - Yang Zhongping; Wang Yao; Li Xuyong; Ren Shupei; Xu Hui; Chang Jiazhuo (Environmental Science and Pollution Research, 2021)

Ensemble machine learning to evaluate the in vivo acute oral toxicity and in vitro human acetylcholinesterase inhibitory activity of organophosphates - Liangliang Wang; Junjie Ding; Peichang Shi; Li Fu; Li Pan; Jiahao Tian; Dongsheng Cao; Hui Jiang; Xiaoqin Ding (Archives of Toxicology, 2021)

Lipocalin-2-induced proliferative endoplasmic reticulum stress participates in Kawasaki disease-related pulmonary arterial abnormalities - Zhaoling Shi; Yue Yin; Chen Li; Hui Ding; Nan Mu; Yishi Wang; Shanshan Jin; Heng Ma; Manling Liu; Jie Zhou (Science China Life Sciences, 2021)

Association of Single Nucleotide Polymorphism at rs2275294 in the ZNF512B Gene with Prognosis in Amyotrophic Lateral Sclerosis - Haixia Jiang; Baiyuan Yang; Fang Wang; Kelu Li; Yongyun Zhu; Bin Liu; Hui Ren; Sijia Tian; Yanming Xu; Ailan Pang; Xinglong Yang (NeuroMolecular Medicine, 2021)

The Role of lncRNA TUG1 in the Parkinson Disease and Its Effect on Microglial Inflammatory Response - Jiang Cheng; Yangyang Duan; Fengting Zhang; Jin Shi; Hui Li; Feng Wang; Haining Li (NeuroMolecular Medicine, 2021)

DNA Methyltransferase 1 Is Dysregulated in Parkinson’s Disease via Mediation of miR-17 - Hong-Qiu Zhang; Jian-Yong Wang; Zhao-Feng Li; Lei Cui; Shi-Shi Huang; Lan-Bing Zhu; Yue Sun; Rui Yang; Hui-Hui Fan; Xiong Zhang; Jian-Hong Zhu (Molecular Neurobiology, 2021)

Roles of bulk and rhizosphere denitrifying bacteria in denitrification from paddy soils under straw return condition - Ning Wang; Ya-Hui Zhao; Jian-Guang Yu; Li-Hong Xue; Hong-Bo Li; Lin-Zhang Yang (Journal of Soils and Sediments, 2021)

Sublethal dose of warfarin induction promotes the accumulation of warfarin resistance in susceptible Norway rats - Xiaohui Ma; Yan Chen; Yaqi Ying; Yuanzhao Geng; Dawei Wang; Ning Li; Xiao-Hui Liu; Ying Song (Journal of Pest Science, 2021)

Dehydroabietic acid improves nonalcoholic fatty liver disease through activating the Keap1/Nrf2-ARE signaling pathway to reduce ferroptosis - Gai Gao; Zhishen Xie; Er-wen Li; Yong Yuan; Yu Fu; Pan Wang; Xiaowei Zhang; Yonghui Qiao; Jiangyan Xu; Christian Hölscher; Hui Wang; Zhenqiang Zhang (Journal of Natural Medicines, 2021)

Genome-Wide Investigation of Major Enzyme-Encoding Genes in the Flavonoid Metabolic Pathway in Tartary Buckwheat (Fagopyrum tataricum) - Yingjun Yao; Lei Sun; WenJing Wu; Shuang Wang; Xin Xiao; MinLun Hu; ChengLei Li; HaiXia Zhao; Hui Chen; Qi Wu (Journal of Molecular Evolution, 2021)

A rapid and accurate method for identifying sexuality of Indarbela obliquifasciata Mell (Lepidoptera, Metarbelidae) adults and pupae - Li-Zhi Huo; Long-Hua Sun; Jing-Ai Zhang; Chao Wu; Ya-Hui Hou; Yong-Yue Wang; Zhi-Jie Li; Jia-Ru Deng; Si-Meng Yang; Ke-Ke Bi (International Journal of Tropical Insect Science, 2021)

Intraspecific recurrent selection in V. vinifera: an effective method for breeding of high quality, disease-, cold-, and drought -resistant grapes - Zhi-Lei Wang; Ting-Ting Xue; Fei-Fei Gao; Liang Zhang; Xing Han; Ying Wang; Miao Hui; Dong Wu; Hua Li; Hua Wang (Euphytica, 2021)

Rebaudioside A/TPGS mixed nanomicelles as promising nanocarriers for nimodipine ocular delivery - Xuefei Li; Jingwang Fang; Meng Xin; Qiqi Li; Jun Wang; Hui Yang; Xianggen Wu (Drug Delivery and Translational Research, 2021)

Grid algorithm for large-scale topographic oblique photogrammetry precision enhancement in vegetation coverage areas - Chen Wang; Xiaodi Xu; Liangcheng Yu; Heng Li; Jeffrey Boon Hui Yap (Earth Science Informatics, 2021)

Altered structural and functional connectivity in CSF1R-related leukoencephalopathy - Fei-Xia Zhan; Ze-Yu Zhu; Qing Liu; Hai-Yan Zhou; Xing-Hua Luan; Xiao-Jun Huang; Xiao-Li Liu; Wo-Tu Tian; Shi-Ge Wang; Xiao-Xuan Song; Guang Chen; Ming-Liang Zhao; et al. (Brain Imaging and Behavior, 2021)

Synergistic Effect of Moderate Steam Explosion Pretreatment and Bovine Serum Albumin Addition for Enhancing Enzymatic Hydrolysis of Poplar - Xiaodi Wang; Dayong Ding; Zhong Liu; Jinru Cheng; Xin Li; Lanfeng Hui (BioEnergy Research, 2021)

Tritonibacter aquimaris sp. nov. and Tritonibacter litoralis sp. nov., two novel members of the Roseobacter group isolated from coastal seawater - Na Li; Xiao-yan He; Ning-hua Liu; Tie-ji Gu; Jian Li; Yu-hui Geng; Shan Zhang; Peng Wang; Hui-hui Fu; Mei Shi; Xiu-lan Chen; Yu-zhong Zhang; et al. (Antonie van Leeuwenhoek, 2021)

Distinct methylome patterns contribute to ecotypic differentiation in the growth of the storage organ of a flowering plant (sacred lotus) - Hui Li; Xingyu Yang; Qingfeng Wang; Jinming Chen; Tao Shi (Molecular Ecology, 2021)
DNA methylation is an epigenetic modification involved in phenotypic diversity, plant development, and environmental responses. However, the mechanisms of DNA methylation underpinning the adaption of lotus ( Nelumbo nucifera ) ecotypes to high and low latitudes remain unsolved, especially adaptive evolution of their storage organs. Tropical and temperate lotus ecotypes have thin and enlarged rhizomes which are adapted to low and high latitudes, respectively. Here, we investigated the DNA methylomes and transcriptomes of rhizomes of the temperate and tropical lotus to address this issue. Compared with that of the tropical lotus, the DNA of the temperate lotus was significantly more hypermethylated, indicating an increase in global DNA methylation in the lotus, with rhizome enlargement. Meanwhile, genes associated with differentially methylated regions in their promoters tended to be differentially expressed between the two ecotypes. Interestingly, the genes with their expression negatively correlated with methylation levels in their promoters and genomic regions displayed significantly higher transposon coverage, while the genes showing a significant positive correlation between expression and methylation showed lesser transposon coverage. Further, we identified that DNA methylation, especially in the promoter region, was significantly correlated with the expression of many starch‐biosynthetic, gibberellin‐, and brassinosteroid‐signalling genes associated with rhizome differentiation. Overall, our study unveiled that distinct global and local methylation patterns between the two lotus ecotypes contribute to their expression differences and adaptive phenotypic divergence of their storage organs, highlighting the role of DNA methylation in shaping the ecotypic differentiation of lotus.

Variations of carbon allocation and turnover time across tropical forests - Hui Yang; Philippe Ciais; Yilong Wang; Yuanyuan Huang; Jean‐Pierre Wigneron; Ana Bastos; Jérôme Chave; Jinfeng Chang; Christopher E. Doughty; Lei Fan; Daniel Goll; Emilie Joetzjer; et al. (Global Ecology and Biogeography, 2021)
Aim The carbon sink in tropical forests is a highly uncertain component of the global carbon budget. An understanding of the processes controlling this sink requires better quantification of carbon allocation, stocks and turnover times. Location Tropical forests. Time period 2010–2017. Major taxa studied Tropical forest ecosystem. Methods We develop a novel data assimilation system using satellite‐based annual above‐ground biomass derived from L‐band vegetation optical depth with 25 km × 25 km grid spacing, together with leaf area, to constrain the 25 km × 25 km carbon allocation patterns of net primary productivity (NPP) into the wood, leaf and root pools, and their turnover times. Our average data‐driven estimates of these variables are broadly consistent with independent ground‐based estimates of NPP allocation and wood turnover from forest inventory plots. Results In tropical forest, on average, the NPP allocation into wood (0.30 ± 0.04) is significantly higher than that into leaves (0.24 ± 0.07). From the wet to dry tropics, forest NPP allocation into both wood and leaves declines slightly. The turnover times of forest leaf pools exhibit little spatial variation, whereas the turnover times of wood pools in Africa (median and interquartile range: years) are slightly longer than those in South America ( years) and Southeast Asia ( years). Our datasets reveal emergent trade‐offs across climatic and vegetation gradients between growth and life span/turnover for both wood and leaves. The spatial gradients of NPP allocation to wood/leaves are associated with canopy height, adjusted by climate condition and nutrient acquisition. The spatial gradients of wood and leaf turnover times are influenced mainly by climate and leaf characteristics. Main conclusions Our data‐driven estimates of carbon allocation and turnover times provide a basis for more detailed exploration of these mechanisms in field studies. This highlights that improved model representation of carbon allocation and turnover is necessary for more accurate prediction of future carbon dynamics.

Physiological determinants of biogeography: The importance of metabolic depression to heat tolerance - Ming‐ling Liao; Gao‐yang Li; Jie Wang; David J. Marshall; Tin Yan Hui; Shu‐yang Ma; Yi‐min Zhang; Brian Helmuth; Yun‐wei Dong (Global Change Biology, 2021)
A quantitative understanding of physiological thermal responses is vital for forecasting species distributional shifts in response to climate change. Many studies have focused on metabolic rate as a global metric for analyzing the sublethal effects of changing environments on physiology. Thermal performance curves (TPCs) have been suggested as a viable analytical framework, but standard TPCs may not fully capture physiological responses, due in part to failure to consider the process of metabolic depression. We derived a model based on the nonlinear regression of biological temperature‐dependent rate processes and built a heart rate data set for 26 species of intertidal molluscs distributed from 33°S to ~40°N. We then calculated physiological thermal performance limits with continuous heating using , the temperature at which heart rate is decreased to 50% of the maximal rate, as a more realistic measure of upper thermal limits. Results indicate that heat‐induced metabolic depression of cardiac performance is a common adaptive response that allows tolerance of harsh environments. Furthermore, our model accounted for the high inter‐individual variability in the shape of cardiac TPCs. We then used these TPCs to calculate physiological thermal safety margins (pTSM), the difference between the maximal operative temperature (95th percentile of field temperatures) and of each individual. Using pTSMs, we developed a physiological species distribution model (pSDM) to forecast future geographic distributions. pSDM results indicate that climate‐induced species range shifts are potentially less severe than predicted by a simple correlative SDM. Species with metabolic depression below the optimum temperature will be more thermal resistant at their warm trailing edges. High intraspecific variability further suggests that models based on species‐level vulnerability to environmental change may be problematic. This multi‐scale, mechanistic understanding that incorporates metabolic depression and inter‐individual variability in thermal response enables better predictions about the relationship between thermal stress and species distributions.

Temperature sensitivity of SOM decomposition is linked with a K‐selected microbial community - Hui Li; Shan Yang; Mikhail V. Semenov; Fei Yao; Ji Ye; Rencang Bu; Ruiao Ma; Junjie Lin; Irina Kurganova; Xugao Wang; Ye Deng; Irina Kravchenko; et al. (Global Change Biology, 2021)
Temperature sensitivity (Q 10 ) of soil organic matter (SOM) decomposition is a crucial parameter to predict the fate of soil carbon (C) under global warming. Nonetheless, the response pattern of Q 10 to continuous warming and the underlying mechanisms are still under debate, especially considering the complex interactions between Q 10 , SOM quality, and soil microorganisms. We examined the Q 10 of SOM decomposition across a mean annual temperature (MAT) gradient from −1.9 to 5.1°C in temperate mixed forest ecosystems in parallel with SOM quality and bioavailability, microbial taxonomic composition, and functional genes responsible for organic carbon decomposition. Within this temperature gradient of 7.0°C, the Q 10 values increased with MAT, but decreased with SOM bioavailability. The Q 10 values increased with the prevalence of K‐strategy of soil microbial community, which was characterized by: (i) high ratios of oligotrophic to copiotrophic taxa, (ii) ectomycorrhizal to saprotrophic fungi, (iii) functional genes responsible for degradation of recalcitrant to that of labile C, and (iv) low average 16S rRNA operon copy number. Because the recalcitrant organic matter was mainly utilized by the K‐strategists, these findings independently support the carbon quality‐temperature theory from the perspective of microbial taxonomic composition and functions. A year‐long incubation experiment was performed to determine the response of labile and recalcitrant C pools to warming based on the two‐pool model. The decomposition of recalcitrant SOM was more sensitive to increased temperature in southern warm regions, which might attribute to the dominance of K‐selected microbial communities. It implies that climate warming would mobilize the larger recalcitrant pools in warm regions, exacerbating the positive feedback between increased MAT and CO 2 efflux. This is the first attempt to link temperature sensitivity of SOM decomposition with microbial eco‐strategies by incorporating the genetic information and disentangling the complex relationship between Q 10 and soil microorganisms.

Natural abundance of 13 C and 15 N provides evidence for plant–soil carbon and nitrogen dynamics in a N‐fertilized meadow - Ruzhen Wang; Josep Peñuelas; Tian Li; Heyong Liu; Hui Wu; Yuge Zhang; Jordi Sardans; Yong Jiang (Ecology, 2021)
Natural abundance of carbon (C) and nitrogen (N) stable isotope ratios (δ 13 C and δ 15 N) has been used to indicate ecosystem C and N status and cycling; however, use of this approach to infer plant and microbial N preference under projected ecosystem N enrichment is limited. Here, we investigated natural abundance δ 13 C and δ 15 N of five dominant plant species, and soil δ 15 N of microbial biomass and available N forms under N addition in a meadow steppe. Additional N, applied as urea, led to decreases in δ 15 N of soil NO 3 − (δ 15 N nitrate , from 3.0 to 0.4‰) and increases in δ 15 N of soil (δ 15 N ammonium , from −1.3 to 11‰) and dissolved organic N (δ 15 N DON , from 8.5 to 15‰) that reflected increased net nitrification rates, a possible increase in NH 3 volatilization, and greater availability of the three N forms. An overall increase in δ 15 N of soil total N (δ 15 N TN ) from 7.1 to 7.9‰ indicated accelerated and greater openness of soil N cycling that was also partially revealed by enhanced net N mineralization rates. Plant δ 15 N, which ranged from −1.8 to 2.1‰, generally decreased with N addition, indicating a greater reliance on soil NO 3 − under N‐enrichment conditions. Nitrogen addition decreased δ 15 N of microbial biomass N (from 14 to 2.8‰), possibly because of a shift in preferential N form (DON to ), that indicated a convergence of plant and microbial preferential N forms and an increase in plant–microbial N competition. Microbes were thus more flexible than plants in the use of different forms of N. Addition of N decreased plant litter δ 13 C, whereas plant species δ 13 C remained unaffected, likely because of a shift in the abundance of dominant species with a greater proportion of biomass coming from δ 13 C‐depleted species. Enrichment factor (the difference in plant δ 15 N relative to δ 15 N TN ) of four nonlegume species was negatively related to soil inorganic N availability, net nitrification rate, and net N mineralization rate, and was proven to be a good indicator of ecosystem N status. Our study highlights the importance of natural abundance of 15 N as an indicator of plant–microbial N competition and ecosystem N cycling in meadow steppe grasslands under projected ecosystem N enrichment.

Taste Masking Study Based on an Electronic Tongue: the Formulation Design of 3D Printed Levetiracetam Instant-Dissolving Tablets - Zengming Wang; Jingru Li; Xiaoxuan Hong; Xiaolu Han; Boshi Liu; Xianfu Li; Hui Zhang; Jing Gao; Nan Liu; Xiang Gao; Aiping Zheng (Pharmaceutical Research, 2021)
Purpose Proper taste-masking formulation design is a critical issue for instant-dissolving tablets (IDTs). The purpose of this study is to use the electronic tongue to design the additives of the 3D printed IDTs to improve palatability. Methods A binder jet 3D printer was used to prepare IDTs of levetiracetam. A texture analyzer and dissolution apparatus were used to predict the oral dispersion time and in vitro drug release of IDTs, respectively. The palatability of different formulations was investigated using the ASTREE electronic tongue in combination with the design of experiment and a model for masking bitter taste. Human gustatory sensation tests were conducted to further evaluate the credibility of the results. Results The 3D printed tablets exhibited rapid dispersion (<30 s) and drug release (2.5 min > 90%). The electronic tongue had an excellent ability of taste discrimination, and levetiracetam had a good linear sensing performance based on a partial least square regression analysis. The principal component analysis was used to analyze the signal intensities of different formulations and showed that 2% sucralose and 0.5% spearmint flavoring masked the bitterness well and resembled the taste of corresponding placebo. The results of human gustatory sensation test were consistent with the trend of the electronic tongue evaluation. Conclusions Owing to its objectivity and reproducibility, this technique is suitable for the design and evaluation of palatability in 3D printed IDT development.

New insights into the fine-scale history of western–eastern admixture of the northwestern Chinese population in the Hexi Corridor via genome-wide genetic legacy - Hongbin Yao; Mengge Wang; Xing Zou; Yingxiang Li; Xiaomin Yang; Ailin Li; Hui-Yuan Yeh; Peixin Wang; Zheng Wang; Jingya Bai; Jianxin Guo; Jinwen Chen; et al. (Molecular Genetics and Genomics, 2021)

RET compound inheritance in Chinese patients with Hirschsprung disease: lack of penetrance from insufficient gene dysfunction - Qian Jiang; Yang Wang; Yang Gao; Hui Wang; Zhen Zhang; Qi Li; Shuhua Xu; Wei Cai; Long Li (Human Genetics, 2021)

Targeted deletion of HAI-1 increases prostasin proteolysis but decreases matriptase proteolysis in human keratinocytes - Dajun D. Lu; Yayun Gu; Sheng-Wen A. Li; Robert J. Barndt; Shih-Ming Huang; Jehng-Kang Wang; Hui Chen Su; Michael D. Johnson; Chen-Yong Lin (Human Cell, 2021)

Selenium Supplementation Protects Against Lipopolysaccharide-Induced Heart Injury via Sting Pathway in Mice - Xuan Wang; Bin Yang; Hui-Li Cao; Rui-Ying Wang; Zhao-Yang Lu; Rui-Fang Chi; Bao Li (Biological Trace Element Research, 2021)

Genome sequencing and functional annotation of Bacillus sp. strain BS-Z15 isolated from cotton rhizosphere soil having antagonistic activity against Verticillium dahliae - Zhong-Yi Chen; Xieerwanimu Abuduaini; Nuramina Mamat; Qi-Lin Yang; Meng-Jun Wu; Xin-Rui Lin; Ru Wang; Rong-Rong Lin; Wei-Jun Zeng; Huan-Chen Ning; He-Ping Zhao; Jin-Yu Li; et al. (Archives of Microbiology, 2021)

Genome analysis of Salmonella phage vB_SalM_8-19 (genus Rosemountvirus) - Cong Cong; Wei Bing Dong; Cui Hui Jing; Yuan Yu Yu; Xu Yong Ping; Wang Li Li; Li Shu Ying; Li Ji Bin; Xu Mu; Li Xiao Yu (Archives of Microbiology, 2021)

The Future of Legislation, Policy, Risk Analysis, and Management of Non-Native Freshwater Fishes in China - Shan Li; Hui Wei; Lorenzo Vilizzi; Aibin Zhan; Julian D. Olden; Daniel L. Preston; Stacey A. Clarke; Becky Cudmore; Gareth D. Davies; Xiaoming Wang; Gordon H. Copp (Reviews in Fisheries Science & Aquaculture, 2021)

Flavonoids improve drought tolerance of maize seedlings by regulating the homeostasis of reactive oxygen species - Baozhu Li; Ruonan Fan; Guiling Sun; Ting Sun; Yanting Fan; Shenglong Bai; Siyi Guo; Shiquan Huang; Jiong Liu; Hui Zhang; Pengtao Wang; Xiaohong Zhu; et al. (Plant and Soil, 2021)
Background and aims As drought threatens the yield and quality of maize ( Zea mays L.), it is important to dissect the molecular basis of maize drought tolerance. Flavonoids, participate in the scavenging of oxygen free radicals and alleviate stress-induced oxidative damages. This study aims to dissect the function of flavonoids in the improvement of maize drought tolerance. Methods Using far-infrared imaging screening, we previously isolated a drought overly insensitivity ( doi ) mutant from an ethyl methanesulfonate (EMS)-mutagenized maize library and designated it as doi57 . In this study, we performed a physiological characterization and transcriptome profiling of doi57 in comparison to corresponding wild-type B73 under drought stress. Results Under drought stress, doi57 seedlings displayed lower leaf-surface temperature (LST), faster water loss, and better performance in growth than B73. Transcriptome analysis reveals that key genes involved in flavonoid biosynthesis are enriched among differentially expressed genes in doi57 . In line with these results, more flavonols and less hydrogen peroxide (H 2 O 2 ) were accumulated in guard cells of doi57 than in those of B73 with the decrease of soil water content (SWC). Moreover, the capacity determined from doi57 seedling extracts to scavenge oxygen free radicals was more effective than that of B73 under the drought treatment. Additionally, doi57 seedlings had higher photosynthetic rates, stomatal conductance, transpiration rates, and water use efficiency than B73 exposed to drought stress, resulting in high biomass and greater root/shoot ratios in doi57 mutant plants. Conclusion Flavonoids may facilitate maize seedling drought tolerance by lowering drought-induced oxidative damage as well regulating stomatal movement.

Multifunctionality and microbial communities in agricultural soils regulate the dynamics of a soil-borne pathogen - Yanqing Guo; Hui Luo; Li Wang; Mingying Xu; Yongshan Wan; Minxia Chou; Peng Shi; Gehong Wei (Plant and Soil, 2021)

Divergent Projection Patterns Revealed by Reconstruction of Individual Neurons in Orbitofrontal Cortex - Junjun Wang; Pei Sun; Xiaohua Lv; Sen Jin; Anan Li; Jianxia Kuang; Ning Li; Yadong Gang; Rui Guo; Shaoqun Zeng; Fuqiang Xu; Yu-Hui Zhang (Neuroscience Bulletin, 2021)

A calculation model of the normal coefficient of restitution based on multi-factor interaction experiments - Zhong-Min Ji; Zhi-Jian Chen; Qing-He Niu; Ting-Hui Wang; Tian-Jun Wang; Tian-Li Chen (Landslides, 2021)

COVID-19 illness and autoimmune diseases: recent insights - Juan Li; Hong-Hui Liu; Xiao-Dong Yin; Cheng-Cheng Li; Jing Wang (Inflammation Research, 2021)

Comprehensive dynamic analysis of proteins in the spermatheca of female Haemaphysalis longicornis after copulation - Xiaoshuang Wang; Yuhong Hu; Yanan Han; Xiaomin Xue; Mengxue Li; Xiaohong Yang; Siyang Zhou; Hui Wang; Jingze Liu (Experimental and Applied Acarology, 2021)

Clinical and microbiological characteristics of adults with hospital-acquired pneumonia: a 10-year prospective observational study in China - Yuyao Yin; Chunjiang Zhao; Henan Li; Longyang Jin; Qi Wang; Ruobing Wang; Yawei Zhang; Jiangang Zhang; Hui Wang; Chunxia Yang; Bin Cao; Yingmei Liu; et al. (European Journal of Clinical Microbiology & Infectious Diseases, 2021)

Increased depression risk for elderly women with high blood levels of strontium and barium - Jia Lv; Yan-ling Li; Wen-qiang Ren; Rong Li; Jian-rong Chen; Chao Bao; Zhi-ping Du; Shun Feng; Ling Gu; Hui Gao; Kai-yong Liu; Lin-sheng Yang; et al. (Environmental Chemistry Letters, 2021)

Altered asymmetries of diffusion and volumetry in basal ganglia of schizophrenia - Hui He; Cheng Luo; Ning Li; Zhiliang Li; Mingjun Duan; Gang Yao; Hongming Wang; Manxi He; Dezhong Yao (Brain Imaging and Behavior, 2021)

Short Communication: Effects of Dietary Selenium Supplementation on Selenium Deposition and Antioxidant Status in Postpartum Mice - Zhen-Nan Wang; Hui Li; He Tang; Shu-Jiu Zhang; Mirielle Pauline; Chong-Liang Bi (Biological Trace Element Research, 2021)

Males and females of a polygamous songbird respond differently to mating opportunities - Jia Zheng; Jan Komdeur; Tamás Székely; Maaike A. Versteegh; Donglai Li; Hui Wang; Zhengwang Zhang (Behavioral Ecology and Sociobiology, 2021)

Polymorphisms in the DC-SIGN gene and their association with the severity of hand, foot, and mouth disease caused by enterovirus 71 - Ya-Ping Li; Mu-Qi Wang; Chen-Rui Liu; Hui-Ling Deng; Yuan Wu; Shuang-Suo Dang; Li-Hong Xu (Archives of Virology, 2021)

Analysis of scale effect and change characteristics of ecological landscape pattern in urban waters - Hui Wang; Chang Li (Arabian Journal of Geosciences, 2021)

Rare taxa maintain the stability of crop mycobiomes and ecosystem functions - Chao Xiong; Ji‐Zheng He; Brajesh K. Singh; Yong‐Guan Zhu; Jun‐Tao Wang; Pei‐Pei Li; Qin‐Bing Zhang; Li‐Li Han; Ju‐Pei Shen; An‐Hui Ge; Chuan‐Fa Wu; Li‐Mei Zhang (Environmental Microbiology, 2021)
Summary Plants harbour highly diverse mycobiomes which sustain essential functions for host health and productivity. However, ecological processes that govern the plant–mycobiome assembly, interactions and their impact on ecosystem functions remain poorly known. Here we characterized the ecological role and community assembly of both abundant and rare fungal taxa along the soil–plant continuums (rhizosphere, phyllosphere and endosphere) in the maize–wheat/barley rotation system under different fertilization practices at two contrasting sites. Our results indicate that mycobiome assembly is shaped predominantly by compartment niche and host species rather than by environmental factors. Moreover, crop‐associated fungal communities are dominated by few abundant taxa mainly belonging to Sordariomycetes and Dothideomycetes, while the majority of diversity within mycobiomes are represented by rare taxa. For plant compartments, the abundant sub‐community is mainly determined by stochastic processes. In contrast, the rare sub‐community is more sensitive to host selection and mainly governed by deterministic processes. Furthermore, our results demonstrate that rare taxa play an important role in fungal co‐occurrence network and ecosystem functioning like crop yield and soil enzyme activities. These results significantly advance our understanding of crop mycobiome assembly and highlight the key role of rare taxa in sustaining the stability of crop mycobiomes and ecosystem functions.

Clinical significance of serum miR-487b in HBV-related hepatocellular carcinoma and its potential mechanism - Xiuping Li; Yuzhen Guo; Xiyan Wang; Anning Ge; Hui Wang; Kaiyun Fan; Changtong Guo (Infectious Diseases, 2021)

Effects of simulated drought stress on carotenoid contents and expression of related genes in carrot taproots - Rong-Rong Zhang; Ya-Hui Wang; Tong Li; Guo-Fei Tan; Jian-Ping Tao; Xiao-Jun Su; Zhi-Sheng Xu; Yong-Sheng Tian; Ai-Sheng Xiong (Protoplasma, 2021)

Core Cell Cycle–Related Gene Identification and Expression Analysis in Maize - Qianlin Xiao; Bin Wei; Yayun Wang; Hui Li; Huanhuan Huang; Babatope Samuel Ajayo; Yufeng Hu; Yubi Huang (Plant Molecular Biology Reporter, 2021)

Effects of grazing on C:N:P stoichiometry attenuate from soils to plants and insect herbivores in a semi-arid grassland - Nazim Hassan; Xiaofei Li; Jianyong Wang; Hui Zhu; Petri Nummi; Deli Wang; Deborah Finke; Zhiwei Zhong (Oecologia, 2021)

Proteomic Analysis of Serum Differentially Expressed Proteins Between Allergic Bronchopulmonary Aspergillosis and Asthma - Hui Cai; Diquan Shuai; Xiaomin Xue; Yuqing Mo; Xixi Song; Ling Ye; Shuiming Li; Daiwei Wang; Yun Wang; Meiling Jin (Mycopathologia, 2021)

Tyrosine kinase Fyn promotes apoptosis after intracerebral hemorrhage in rats by activating Drp1 signaling - Li Zhang; Lu Wang; Han Xiao; Hui Gan; Hui Chen; Shuyue Zheng; Dan Jian; Xuan Zhai; Ning Jiang; Zhao Jing; Ping Liang (Journal of Molecular Medicine, 2021)

Peptides YYGGEGSSSEQG and SESEM Inhibit TNF-α-Induced Smooth Muscle Cells Proliferation and Migration Through Their Bindings to TNF-α Receptor - Dong-Hui Geng; Zhiyuan Ju; Tianzhen Xiao; Sumei Zhou; Lu Huang; Liya Liu; Xianrong Zhou; Lili Wang; Li-Tao Tong (International Journal of Peptide Research and Therapeutics, 2021)

High-Level Expression and Purification of Melittin in Escherichia coli Using SUMO Fusion Partner - Qiu-chi Chen; Lei Liu; Tian-Yi Yu; Lu Tang; Mo-li Yin; Wen-he Zhu; Xiu-yun Jiang; Hui-yan Wang (International Journal of Peptide Research and Therapeutics, 2021)

Efficient Editing of an Adenoviral Vector Genome with CRISPR/Cas9 - Qiang Li; Hui Wang; Chen-yu Gong; Zhao Chen; Jia-xing Yang; Hong-wei Shao; Wen-feng Zhang (Indian Journal of Microbiology, 2021)

SP1-induced AFAP1-AS1 contributes to proliferation and invasion by regulating miR-497-5p/CELF1 pathway in nasopharyngeal carcinoma - Hui Jin; Gengtian Liang; Liping Yang; Li Liu; Binru Wang; Fengqin Yan (Human Cell, 2021)

Enhanced antioxidant capacity and upregulated transporter genes contribute to the UV-B-induced increase in blinin in Conyza blinii - Junyi Zhan; Qin Yang; Zhiyi Lin; Tianrun Zheng; Maojia Wang; Wenjun Sun; Tongliang Bu; Zizhong Tang; Chenglei Li; Xueyi Han; Haixia Zhao; Qi Wu; et al. (Environmental Science and Pollution Research, 2021)

Reclassification of Algibacter wandonensis as a Later Heterotypic Synonym of Algibacter lectus Based on Whole-Genome Sequence Analysis - Ang Liu; Hui Wang; Yuan-Yuan Yang; Qing-Jie Xue; Xiu-Zhen Li (Current Microbiology, 2021)

Decreased Expression of Heat Shock Protein 47 Is Associated with T-2 Toxin and Low Selenium-Induced Matrix Degradation in Cartilages of Kashin-Beck Disease - Meng Zhang; Mengying Wang; Hui Wang; Ying Zhang; Zhengzheng Li; Yiping Feng; Yinan Liu; Yue Liu; Yucheng Liao; Wenjun Wang; Qian Fang; Jinghong Chen (Biological Trace Element Research, 2021)

Effects of degradation succession of alpine wetland on soil organic carbon and total nitrogen in the Yellow River source zone, west China - Chun-ying Lin; Xi-lai Li; Jing Zhang; Hua-fang Sun; Juan Zhang; Hui-bang Han; Qi-hua Wang; Cheng-biao Ma; Cheng-yi Li; Yu-xing Zhang; Xue-qian Ma (Journal of Mountain Science, 2021)

Identification and characterization of Colletotrichum gloeosporioides sensu stricto, the agent of anthracnose disease of Sorbaria sorbifolia in China - Qing-Hai Wang; Xiang-Ying Li; Ting-Ting Xu; Meng-Ai Zhang; Yu-Hui Yang; Pei-Bo Feng; Su-Su Fan; Zhen-Yu Liu (Journal of General Plant Pathology, 2021)

Suppression of miR-4463 promotes phenotypic switching in VSMCs treated with Ox-LDL - Xueqin Wang; Hui Li; Yuetian Zhang; Qi Liu; Xiaolei Sun; Xuemei He; Qian Yang; Ping Yuan; Xiangyu Zhou (Cell and Tissue Research, 2021)

Numerical study of scour depth effect on wave-induced seabed response and liquefaction around a pipeline - Hui Li; Shuqing Wang; Xuguang Chen; Cun Hu; Jinzhong Liu (Marine Georesources & Geotechnology, 2021)

Allometric growth and carbon storage in the mangrove Sonneratia apetala - Dehuang Zhu; Dafeng Hui; Mengqi Wang; Qiong Yang; Zhen Li; Zijian Huang; Hanmeng Yuan; Shixiao Yu (Wetlands Ecology and Management, 2021)

QTL mapping for foxtail millet plant height in multi-environment using an ultra-high density bin map - Qiang He; Hui Zhi; Sha Tang; Lu Xing; Suying Wang; Haigang Wang; Aiying Zhang; Yuhui Li; Ming Gao; Haijin Zhang; Guoqiu Chen; Shutao Dai; et al. (Theoretical and Applied Genetics, 2021)

Carnosic acid alleviates depression-like behaviors on chronic mild stressed mice via PPAR-γ-dependent regulation of ADPN/FGF9 pathway - Xiao-qing Wang; Ya-hui Tang; Gui-rong Zeng; Li-feng Wu; Ying-jun Zhou; Ze-neng Cheng; De-Jian Jiang (Psychopharmacology, 2021)

A candidate PpRPH gene of the D locus controlling fruit acidity in peach - Lu Wang; Xiaohan Jiang; Li Zhao; Furong Wang; Yudi Liu; Hui Zhou; Huaping He; Yuepeng Han (Plant Molecular Biology, 2021)

A Rehmannia glutinosa cinnamate 4-hydroxylase promotes phenolic accumulation and enhances tolerance to oxidative stress - Yan Hui Yang; Heng Yang; Rui Fang Li; Cui Xiang Li; Lei Zeng; Chao Jie Wang; Na Li; Zhuang Luo (Plant Cell Reports, 2021)

Seed-specific expression of TaYUC10 significantly increases auxin and protein content in wheat seeds - Yanlin Yang; Na Li; Wenrong Hui; Binjie Yuan; Pan Fan; Jingxia Liu; Honggang Wang; Deshun Feng (Plant Cell Reports, 2021)

Comprehensive analysis of coding sequence architecture features and gene expression in Arachis duranensis - Shuwei Dong; Long Zhang; Wenhui Pang; Yongli Zhang; Chang Wang; Zhenyi Li; Lichao Ma; Wei Tang; Guofeng Yang; Hui Song (Physiology and Molecular Biology of Plants, 2021)

Using Composite Phenotypes to Reveal Hidden Physiological Heterogeneity in High-Altitude Acclimatization in a Chinese Han Longitudinal Cohort - Yi Li; Yanyun Ma; Kun Wang; Menghan Zhang; Yi Wang; Xiaoyu Liu; Meng Hao; Xianhong Yin; Meng Liang; Hui Zhang; Xiaofeng Wang; Xingdong Chen; et al. (Phenomics, 2021)
Altitude acclimatization is a human physiological process of adjusting to the decreased oxygen availability. Since several physiological processes are involved and their correlations are complicated, the analyses of single traits are insufficient in revealing the complex mechanism of high-altitude acclimatization. In this study, we examined these physiological responses as the composite phenotypes that are represented by a linear combination of physiological traits. We developed a strategy that combines both spectral clustering and partial least squares path modeling (PLSPM) to define composite phenotypes based on a cohort study of 883 Chinese Han males. In addition, we captured 14 composite phenotypes from 28 physiological traits of high-altitude acclimatization. Using these composite phenotypes, we applied k-means clustering to reveal hidden population physiological heterogeneity in high-altitude acclimatization. Furthermore, we employed multivariate linear regression to systematically model (Models 1 and 2) oxygen saturation (SpO 2 ) changes in high-altitude acclimatization and evaluated model fitness performance. Composite phenotypes based on Model 2 fit better than single trait-based Model 1 in all measurement indices. This new strategy of using composite phenotypes may be potentially employed as a general strategy for complex traits research such as genetic loci discovery and analyses of phenomics.

The Function of β-1,4-Glucuronosyltransferase WelK in the Sphingan WL Gum Biosynthesis Process in Marine Sphingomonas sp. WG - Hui Li; Kehui Li; Zhongrui Guo; Han Xue; Jing Li; Sixue Ji; Jiqian Wang; Hu Zhu (Marine Biotechnology, 2021)

Spatial variability of the molecular composition of humic acids from subtropical forest soils - Li Jiang; Jun Zhu; Hui Wang; Qingling Fu; Hongqing Hu; Qiaoyun Huang (Journal of Soils and Sediments, 2021)

Preliminary report on the improved resistance towards Pseudomonas syringae pv. actinidiae of cultivated kiwifruit (Actinidia chinensis) when grafted onto wild Actinidia guilinensis rootstock in vitro - Fa-ming Wang; Jie-wei Li; Kai-yu Ye; Hong-juan Gong; Ping-ping Liu; Qiao-sheng Jiang; Bei-bei Qi; Quan-hui Mo (Journal of Plant Pathology, 2021)

SUMO modification in apoptosis - Peiyao Li; Huiru Jing; Yanzhe Wang; Lei Yuan; Hui Xiao; Qian Zheng (Journal of Molecular Histology, 2021)
Apoptosis and clearance of dead cells is highly evolutionarily conserved from nematode to humans, which is crucial to the growth and development of multicellular organism. Fail to remove apoptotic cells often lead to homeostasis imbalance, fatal autoimmune diseases, and neurodegenerative diseases. Small ubiquitin-related modifiers (SUMOs) modification is a post-translational modification of ubiquitin proteins mediated by the sentrin-specific proteases (SENPs) family. SUMO modification is widely involved in many cellular biological process, and abnormal SUMO modification is also closely related to many major human diseases. Recent researches have revealed that SUMO modification event occurs during apoptosis and clearance of apoptotic cells, and plays an important role in the regulation of apoptotic signaling pathways. This review summarizes some recent progress in the revelation of regulatory mechanisms of these pathways and provides some potential researching hotpots of the SUMO modification regulation to apoptosis.

NDRG2 is expressed on enteric glia and altered in conditions of inflammation and oxygen glucose deprivation/reoxygenation - Yuxin Zhang; Hui Gao; Na Li; Haiqing Chang; Bo Cheng; Yansong Li; Jiwen Miao; Shuang Li; Qiang Wang (Journal of Molecular Histology, 2021)

A novel defensin-like peptide contributing to antimicrobial and antioxidant capacity of the tick Dermacentor silvarum (Acari: Ixodidae) - Fengjiao Li; Zhihua Gao; Kuang Wang; Yinan Zhao; Hui Wang; Meichen Zhao; Yawen Zhao; Lingqian Bai; Zhijun Yu; Xiaolong Yang (Experimental and Applied Acarology, 2021)

Cerebral microbleeds and their influence on cognitive impairment in Dialysis patients - Yujun Qian; Ke Zheng; Haiyun Wang; Hui You; Fei Han; Jun Ni; Bo Hou; Limeng Chen; Yicheng Zhu; Feng Feng; Xuemei Li (Brain Imaging and Behavior, 2021)

A drug-tunable Flt23k gene therapy for controlled intervention in retinal neovascularization - Jinying Chen; Fan-Li Lin; Jacqueline Y. K. Leung; Leilei Tu; Jiang-Hui Wang; Yu-Fan Chuang; Fan Li; Hsin-Hui Shen; Gregory J. Dusting; Vickie H. Y. Wong; Leszek Lisowski; Alex W. Hewitt; et al. (Angiogenesis, 2021)

Experimental evidence for long‐term coexistence of copiotrophic and oligotrophic bacteria in pelagic surface seawater - Yi Li; Zhi‐Bin Wang; Xi‐Ying Zhang; Yan‐Ru Dang; Lin‐Lin Sun; Wei‐Peng Zhang; Hui‐Hui Fu; Gui‐Peng Yang; Min Wang; Andrew McMinn; Xiu‐Lan Chen; Yin Chen; et al. (Environmental Microbiology, 2021)
Summary Most marine copiotrophic bacteria can produce extracellular enzymes to degrade biopolymers into bio‐available smaller solutes, while oligotrophic bacteria usually cannot. Bacterial extracellular enzymes and enzymatic products can be a common resource that could be utilized by both copiotrophs and oligotrophs; when present, oligotrophs may outcompete the enzyme‐producing copiotrophs. However, copiotrophs and oligotrophs consistently coexist in the ocean. How they maintain coexistence has still not been experimentally studied. In this study, the interaction and coexistence of a copiotroph and an oligotroph, isolated from the same surface seawater sample and utilizing the same proteinaceous substrate, were experimentally investigated. The copiotroph could secrete extracellular proteases to degrade and then utilize the proteinaceous substrate. The oligotroph was unable to utilize the proteinaceous substrate by itself, but could grow by using the hydrolysate amino acids. The copiotroph outcompeted the oligotroph by adsorbing the amino acids quickly and having a higher growth rate in the rich medium. The oligotroph survived by adapting to low concentration of nutrients. The copiotroph and oligotroph were able to maintain long‐term (up to 142 days) coexistence in the laboratory. This study indicates that differences in the utilization of different concentrations of nutrients can drive the coexistence of marine copiotrophs and oligotrophs.

Fatigue Characteristic of Designed T-Type Specimen under Two-Step Repeating Variable Amplitude Load with Low-Amplitude Load below the Fatigue Limit - Jin Gan; Di Sun; Hui Deng; Zhou Wang; Xiaoli Wang; Li Yao; Weiguo Wu (Journal of Marine Science and Engineering, 2021)
In order to investigate the non-linear fatigue cumulative damage of joints in ocean structural parts, one type of low carbon steel Q345D was employed to prepare designed T-type specimens, and a series of fatigue experiments were carried out on the specimens under two-step repeating variable amplitude loading condition. The chosen high cyclic loads were larger than the constant amplitude fatigue limit (CAFL) and the chosen low cyclic loads were below the CAFL. Firstly, the S-N curve of designed T-type specimen was obtained via different constant amplitude fatigue tests. Then, a series of two-step repeating variable load were carried out on designed T-type specimens with the aim of calculating the cumulative damage of specimen under the variable fatigue load. The discussions about non-linear fatigue cumulative damage of designed T-type specimens and the interaction effect between the high and low amplitude loadings on the fatigue life were carried out, and some meaningful conclusions were obtained according to the series of fatigue tests. The results show that fatigue cumulative damage of designed T-type specimens calculated based on Miner’s rule ranges from 0.513 to 1.756. Under the same cycle ratio, the cumulative damage increases with the increase of high cyclic stress, and at the same stress ratio, the cumulative damage increases linearly with the increase of cycle ratio. Based on the non-linear damage evaluation method, it is found that the load interaction effect between high and low stress loads exhibits different damage or strengthening effects with the change of stress ratio and cycle ratio.

Modes of genetic adaptations underlying functional innovations in the rumen - Xiangyu Pan; Yudong Cai; Zongjun Li; Xianqing Chen; Rasmus Heller; Nini Wang; Yu Wang; Chen Zhao; Yong Wang; Han Xu; Songhai Li; Ming Li; et al. (Science China Life Sciences, 2021)

The Ocean Heat Content Changes in the South China Sea due to Tropical Cyclones with Different Tracks - Long Yu; Jia Sun; Zhenli Hui; Xuejun Xiong; Shanshan Jin; Lu Wang; Guangbing Yang; Yanliang Guo; Xia Ju; Liang Chen; Xiaomin Hu; Ying Li (Pure and Applied Geophysics, 2021)

Effects of shading on lignin biosynthesis in the leaf of tea plant (Camellia sinensis (L.) O. Kuntze) - Rui-Min Teng; Yong-Xin Wang; Hui Li; Shi-Jia Lin; Hao Liu; Jing Zhuang (Molecular Genetics and Genomics, 2021)

A heterozygous hypomorphic mutation of Fanca causes impaired follicle development and subfertility in female mice - Yuncheng Pan; Xi Yang; Feng Zhang; Siyuan Chen; Zixue Zhou; Hao Yin; Hui Ma; Lingyue Shang; Jialin Yang; Guoqing Li; Yingchen Wang; Li Jin; et al. (Molecular Genetics and Genomics, 2021)

Advances in intervention methods and brain protection mechanisms of in situ and remote ischemic postconditioning - Chun-Yan Li; Wei Ma; Kuang-Pin Liu; Jin-Wei Yang; Xian-Bin Wang; Zhen Wu; Tong Zhang; Jia-Wei Wang; Wei Liu; Jie Liu; Yu Liang; Xing-Kui Zhang; et al. (Metabolic Brain Disease, 2021)

A Fluorogenic and Chromogenic Probe Distinguishes Fluoride Anions and Thiols: Implications for Discrimination of Fluoride-Containing G Series and Sulfur-Containing V Series Nerve Agents - Wei-hui Wu; Xin Wang; Liang Zong; Dan Li; Yan-hua Xiao; Shao-hui Sui; Jian Li; Meng Liu; Gao-yun Chen; Teng Luo; Min Liu; Xin-ming Wang; et al. (Journal of Fluorescence, 2021)

High bioremediation potential of strain Chenggangzhangella methanolivorans CHL1 for soil polluted with metsulfuron-methyl or tribenuron-methyl in a pot experiment - Ting-Ting Yang; Hui-Wen Zhang; Jian Wang; Xin-Yu Li; Xu Li; Zhen-Cheng Su (Environmental Science and Pollution Research, 2021)

Accumulation of Cd by three forage mulberry (Morus atropurpurea Roxb.) cultivars in heavy metal–polluted farmland: a field experiment - Yongbing Jiang; Shimeng Jiang; Renzhi Huang; Ming Wang; Hui Cao; Zhangbao Li (Environmental Science and Pollution Research, 2021)

Improving the observation and prediction capabilities for Arctic marine environment: from the perspective of Arctic Shipping - Hui Wang; Qizhen Sun; Lin Zhang; Xi Liang; Qinghua Yang; Na Liu; Chunhua Li; Qingsheng Liu; Bingrui Li; Qian Feng; Xiao Cheng; Yi Yu (Acta Oceanologica Sinica, 2021)

Phosphorus addition decreases microbial residual contribution to soil organic carbon pool in a tropical coastal forest - Ye Yuan; Yue Li; Zhijian Mou; Luhui Kuang; Wenjia Wu; Jing Zhang; Faming Wang; Dafeng Hui; Josep Peñuelas; Jordi Sardans; Hans Lambers; Jun Wang; et al. (Global Change Biology, 2021)
The soil nitrogen (N) and phosphorus (P) availability often constrains soil carbon (C) pool, and elevated N deposition could further intensify soil P limitation, which may affect soil C cycling in these N‐rich and P‐poor ecosystems. Soil microbial residues may not only affect soil organic carbon (SOC) pool but also impact SOC stability through soil aggregation. However, how soil nutrient availability and aggregate fractions affect microbial residues and the microbial residue contribution to SOC is still not well understood. We took advantage of a 10‐year field fertilization experiment to investigate the effects of nutrient additions, soil aggregate fractions, and their interactions on the concentrations of soil microbial residues and their contribution to SOC accumulation in a tropical coastal forest. We found that continuous P addition greatly decreased the concentrations of microbial residues and their contribution to SOC, whereas N addition had no significant effect. The P‐stimulated decreases in microbial residues and their contribution to SOC were presumably due to enhanced recycling of microbial residues via increased activity of residue‐decomposing enzymes. The interactive effects between soil aggregate fraction and nutrient addition were not significant, suggesting a weak role of physical protection by soil aggregates in mediating microbial responses to altered soil nutrient availability. Our data suggest that the mechanisms driving microbial residue responses to increased N and P availability might be different, and the P‐induced decrease in the contribution of microbial residues might be unfavorable for the stability of SOC in N‐rich and P‐poor tropical forests. Such information is critical for understanding the role of tropical forests in the global carbon cycle.

Inland fisheries development versus aquatic biodiversity conservation in China and its global implications - Hui Zhang; Jinming Wu; Harry Gorfine; Xiujuan Shan; Li Shen; Haile Yang; Hao Du; Junyi Li; Chengyou Wang; Qiong Zhou; Zhigang Liu; Myounghee Kang; et al. (Reviews in Fish Biology and Fisheries, 2020)

Carbon storage and plant-soil linkages among soil aggregates as affected by nitrogen enrichment and mowing management in a meadow grassland - Ruzhen Wang; Hui Wu; Jordi Sardans; Tianpeng Li; Heyong Liu; Josep Peñuelas; Feike A. Dijkstra; Yong Jiang (Plant and Soil, 2020)

Correction to: Involvement of proBDNF in Monocytes/Macrophages with Gastrointestinal Disorders in Depressive Mice - Yun-Qing Yu; Yan-Ling Zhang; Zhe Wang; Yu Liu; Hui Li; Chang-Qi Li; Xin-Fu Zhou; Zhao-Lan Hu; Ru-Ping Dai (Neurotoxicity Research, 2020)

Involvement of proBDNF in Monocytes/Macrophages with Gastrointestinal Disorders in Depressive Mice - Yun-Qing Yu; Yan-Ling Zhang; Zhe Wang; Yu Liu; Hui Li; Xin-Fu Zhou; Zhao-Lan Hu; Ru-Ping Dai (Neurotoxicity Research, 2020)

Grafting Alleviates Cadmium Toxicity and Reduces Its Absorption by Tomato - Yongdong Xie; Huaqiang Tan; Guochao Sun; Huanxiu Li; Dong Liang; Hui Xia; Xun Wang; Ming’an Liao; Honghong Deng; Jin Wang; Yi Tang (Journal of Soil Science and Plant Nutrition, 2020)

Transcriptome-wide identification and profiling of miRNAs in a stress-tolerant conifer Sabina chinensis - Xian-Ge Hu; Shan-Shan Zhou; Ying Yang; Hui Liu; Shrestha Anil; Qing Wang; Wei Zhao; Qiong Gao; Yousry A El-Kassaby; Tongli Wang; Yue Li; Jian-Feng Mao (Journal of Biosciences, 2020)

The relationships of serum homocysteine levels and traditional lipid indicators with disease activity and coronary artery involvement in Takayasu arteritis - Si Chen; Haixia Luan; Jianxun He; Yan Wang; Xiaoli Zeng; Yongzhe Li; Hui Yuan (Immunologic Research, 2020)

Analyzing adaptation strategies for maize production under future climate change in Guanzhong Plain, China - Qaisar Saddique; Huanjie Cai; Jiatun Xu; Ali Ajaz; Jianqiang He; Qiang Yu; Yunfei Wang; Hui Chen; Muhammad Imran Khan; De Li Liu; Liang He (Mitigation and Adaptation Strategies for Global Change, 2020)

Models and measurements of seven years of evapotranspiration on a high elevation site on the Central Tibetan Plateau - Li-hui Wang; Xiao-bo He; Jakob F. Steiner; Dong-wei Zhang; Jin-kui Wu; Shao-yong Wang; Yong-jian Ding (Journal of Mountain Science, 2020)

SNP of AHSA2 gene in three cattle breeds using snapshot technology - Shu-Zhu Cheng; E. Guang-Xin; Cheng-Li Liu; Wang-Dui Basang; Yan-Bin Zhu; Ri-Su Na; Yan-Guo Han; Yan Zeng; Xiao Wang; Wei-Wei Ni; Bai-Gao Yang; Xing-Hai Duan; et al. (Journal of Genetics, 2020)

Comprehensively Understanding Enzymatic Hydrolysis of Lignocellulose and Cellulase–Lignocellulose Adsorption by Analyzing Substrates’ Physicochemical Properties - Tianqing Lan; Yanxing Jiang; Wenqiu Zheng; Shunran Wang; Shen Sang; Hui Li (BioEnergy Research, 2020)

2020 taxonomic update for phylum Negarnaviricota (Riboviria: Orthornavirae), including the large orders Bunyavirales and Mononegavirales - Jens H. Kuhn; Scott Adkins; Daniela Alioto; Sergey V. Alkhovsky; Gaya K. Amarasinghe; Simon J. Anthony; Tatjana Avšič-Županc; María A. Ayllón; Justin Bahl; Anne Balkema-Buschmann; Matthew J. Ballinger; Tomáš Bartonička; et al. (Archives of Virology, 2020)

High-frequency compensation for seismic data based on adaptive generalized S transform - Hui-Feng Li; Jin Wang; Zheng-Rong Wei; Fei-Long Yang (Applied Geophysics, 2020)

Effect analysis of borehole microseismic monitoring technology on shale gas fracturing in western Hubei - Juan Li; Bing-Song Yu; Yu-Kun Tian; Hai-Xia Kang; Yu-Fang Wang; Hui Zhou (Applied Geophysics, 2020)

Small Jellyfish as a Supplementary Autumnal Food Source for Juvenile Chaetognaths in Sanya Bay, China - Lingli Wang; Minglan Guo; Tao Li; Hui Huang; Sheng Liu; Simin Hu (Journal of Marine Science and Engineering, 2020)
Information on the in situ diet of juvenile chaetognaths is critical for understanding the population recruitment of chaetognaths and their functional roles in marine food web. In this study, a molecular method based on PCR amplification targeted on 18S rDNA was applied to investigate the diet composition of juvenile Flaccisagitta enflata collected in summer and autumn in Sanya Bay, China. Diverse diet species were detected in the gut contents of juvenile F. enflata, including copepods, small jellyfish, anthozoa, polychaetes, echinoderms, diatoms and dinoflagellates. The diet composition showed obvious differences between summer and autumn. Copepod, such as Temora turbinata, Canthocalanus pauper and Subeucalanus crassus, dominated the diet in summer, representing up to 61% of the total prey items. However, small jellyfish, mainly consisting of Bougainvillia fulva, Solmissus marshalli and Pleurobrachia globosa, was the main food group (72.9%) in autumn. Environmental parameters showed no significant difference between summer and autumn. The mean abundance of juvenile chaetognaths in autumn was about eight times higher than that in summer, while the abundance of potential food prey was similar in both seasons. Our results suggested that juveniles chaetognaths might consume small jellyfish as a supplementary food source under enhanced feeding competition in autumn.

Solanrubiellin A, a hydroanthraquinone dimer with antibacterial and cytotoxic activity from Solanum lyratum - Hui Chen; Kun Du; Yan-Jun Sun; Zhi-You Hao; Yan-Li Zhang; Jiang Bai; Qing-Hua Wang; Hai-Yu Hu; Wei-Sheng Feng (Natural Product Research, 2020)

CD49a+CD49b+ NK cells induced by viral infection reflect an activated state of conventional NK cells - Wenhan Li; Jing Zhou; Xianwei Wang; Yuzhang Wu; Lilin Ye; Haiming Wei; Rui Sun; Zhigang Tian; Hui Peng (Science China Life Sciences, 2020)

Ferrous iron-induced increases in capitate glandular trichome density and upregulation of CbHO-1 contributes to increases in blinin content in Conyza blinii - Tianrun Zheng; Maojia Wang; Junyi Zhan; Wenjun Sun; Qin Yang; Zhiyi Lin; Tongliang Bu; Zizhong Tang; Chenglei Li; Jun Yan; Zhi Shan; Hui Chen (Planta, 2020)

WDR5a functions in cadmium-inhibited root meristem growth by regulating nitric oxide accumulation in Arabidopsis - Yu Zhang; Yang-Yang Tian; Lin-Feng Wang; Yun-Hui Li; Ting-Ting Li; Wen-Cheng Liu (Planta, 2020)

MiR-132-3p serves as a tumor suppressor in mantle cell lymphoma via directly targeting SOX11 - Baoyu Wu; Jingyu Li; Han Wang; Qian Wu; Hui Liu (Naunyn-Schmiedeberg's Archives of Pharmacology, 2020)

Metabolic diversification of anaerobic methanotrophic archaea in a deep-sea cold seep - Wen-Li Li; Yu-Zhi Wu; Guo-wei Zhou; Hui Huang; Yong Wang (Marine Life Science & Technology, 2020)
Anaerobic methanotrophic archaea (ANME) can assimilate methane and govern the greenhouse effect of deep-sea cold seeps. In this study, a total of 13 ANME draft genomes representing five ANME types (ANME-1a, ANME-1b, ANME-2a, ANME-2b and ANME-2c), in size between 0.8 and 1.8 Mbp, were obtained from the Jiaolong cold seep in the South China Sea. The small metagenome-assembled genomes (MAGs) contained all the essential pathways for methane oxidization and carbon dioxide fixation. All genes related to nitrate and sulfate reduction were absent from the MAGs, indicating their syntrophic dependence on partner organisms. Aside from acetate secretion and sugar storage, propanoate synthesis pathway, as an alternative novel carbon flow, was identified in all the MAGs and transcriptionally active. Regarding type-specific features of the MAGs, the genes encoding archaellum and bacteria-derived chemotaxis were specific to ANME-2, perhaps for fitness under fluctuation of methane and sulfate concentration flux. Our genomic and transcriptomic results strongly suggested that ANME could carry out simple carbon metabolism from C1 assimilation to C3 biosynthesis in the SCS cold seep, which casts light on a novel approach for synthetic biology.

Astragaloside protects rat brain from microwave-induced functional injuries via restoring acetylcholine and normalizing electroencephalogram - Li Zhao; Yunbo Sun; Chao Yu; Junjun Chen; Xinping Xu; Xueyan Zhang; Hui Wang; Jing Zhang; Haoyu Wang; Ji Dong; Binwei Yao; Hongmei Zhou; et al. (Environmental Science and Pollution Research, 2020)

Effects of intercropping accumulator plants and applying their straw on the growth and cadmium accumulation of Brassica chinensis L. - Yi Tang; Liming Wang; Yongdong Xie; Xuena Yu; LiJin Lin; Huanxiu Li; Ming’an Liao; Zhihui Wang; Guochao Sun; Dong Liang; Hui Xia; Xun Wang; et al. (Environmental Science and Pollution Research, 2020)

Aluminum and magnesium status during pregnancy and placenta oxidative stress and inflammatory mRNA expression: China Ma’anshan birth cohort study - Jian-Qing Wang; Ya-Bin Hu; Chun-Mei Liang; Xun Xia; Zhi-Juan Li; Hui Gao; Jie Sheng; Kun Huang; Su-Fang Wang; Yan Li; Peng Zhu; Jia-Hu Hao; et al. (Environmental Geochemistry and Health, 2020)

A long glacier mass balance record analysis in Chinese Urumqi Glacier No. 1 and the relationships with changes in large-scale circulations - Huai Baojuan; Sun Weijun; Wang Junyao; Wang Yetang; Li Zhongqin; Zhang Hui (Arabian Journal of Geosciences, 2020)

Variation in dustfall on the western Chinese Loess Plateau - Xunming Wang; Diwen Cai; Junpeng Lou; Zhenghua Tao; Hui Li; Caixia Zhang (Arabian Journal of Geosciences, 2020)

Sulfur isotopic compositions of sulfides along the Southwest Indian Ridge: implications for mineralization in ultramafic rocks - Teng Ding; Chunhui Tao; Ágata Alveirinho Dias; Jin Liang; Jie Chen; Bin Wu; Dongsheng Ma; Rongqing Zhang; Jia Wang; Shili Liao; Yuan Wang; Weifang Yang; et al. (Mineralium Deposita, 2020)

Genomic prediction across years in a maize doubled haploid breeding program to accelerate early-stage testcross testing - Nan Wang; Hui Wang; Ao Zhang; Yubo Liu; Diansi Yu; Zhuanfang Hao; Dan Ilut; Jeffrey C. Glaubitz; Yanxin Gao; Elizabeth Jones; Michael Olsen; Xinhai Li; et al. (Theoretical and Applied Genetics, 2020)
Key message Genomic selection with a multiple-year training population dataset could accelerate early-stage testcross testing by skipping the first-stage yield testing, which significantly saves the time and cost of early-stage testcross testing. Abstract With the development of doubled haploid (DH) technology, the main task for a maize breeder is to estimate the breeding values of thousands of DH lines annually. In early-stage testcross testing, genomic selection (GS) offers the opportunity of replacing expensive multiple-environment phenotyping and phenotypic selection with lower-cost genotyping and genomic estimated breeding value (GEBV)-based selection. In the present study, a total of 1528 maize DH lines, phenotyped in multiple-environment trials in three consecutive years and genotyped with a low-cost per-sample genotyping platform of rAmpSeq, were used to explore how to implement GS to accelerate early-stage testcross testing. Results showed that the average prediction accuracy estimated from the cross-validation schemes was above 0.60 across all the scenarios. The average prediction accuracies estimated from the independent validation schemes ranged from 0.23 to 0.32 across all the scenarios, when the one-year datasets were used as training population (TRN) to predict the other year data as testing population (TST). The average prediction accuracies increased to a range from 0.31 to 0.42 across all the scenarios, when the two-years datasets were used as TRN. The prediction accuracies increased to a range from 0.50 to 0.56, when the TRN consisted of two-years of breeding data and 50% of third year’s data converted from TST to TRN. This information showed that GS with a multiple-year TRN set offers the opportunity to accelerate early-stage testcross testing by skipping the first-stage yield testing, which significantly saves the time and cost of early-stage testcross testing.

Major genomic regions responsible for wheat yield and its components as revealed by meta-QTL and genotype–phenotype association analyses - Hui Liu; Daniel Mullan; Chi Zhang; Shancen Zhao; Xin Li; Aimin Zhang; Zhanyuan Lu; Yong Wang; Guijun Yan (Planta, 2020)

FtMYB18 acts as a negative regulator of anthocyanin/proanthocyanidin biosynthesis in Tartary buckwheat - Qixin Dong; Haixia Zhao; Yunji Huang; Ying Chen; Min Wan; Zixian Zeng; Panfeng Yao; Chenglei Li; Xiaoli Wang; Hui Chen; Qi Wu (Plant Molecular Biology, 2020)

Liquiritin inhibits proliferation and induces apoptosis in HepG2 hepatocellular carcinoma cells via the ROS-mediated MAPK/AKT/NF-κB signaling pathway - Jia-Ru Wang; Tian-Zhu Li; Cheng Wang; Shu-Mei Li; Ying-Hua Luo; Xian-Ji Piao; Yu-Chao Feng; Yi Zhang; Wan-Ting Xu; Yu Zhang; Tong Zhang; Shi-Nong Wang; et al. (Naunyn-Schmiedeberg's Archives of Pharmacology, 2020)

Phylogenetic relationship and taxonomy of a hybrid Epichloë species symbiotic with Festuca sinensis - Pei Tian; Wenbo Xu; Chunjie Li; Hui Song; Meining Wang; Christopher L. Schardl; Zhibiao Nan (Mycological Progress, 2020)

The anti-inflammatory drug dimethyl itaconate protects against colitis-associated colorectal cancer - Qian Wang; Xin Ling Li; Yan Mei; Jia-Chong Ye; Wei Fan; Guang-Hui Cheng; Mu-Sheng Zeng; Guo-Kai Feng (Journal of Molecular Medicine, 2020)

Histidine kinase NME1 and NME2 are involved in TGF-β1-induced HSC activation and CCl4-induced liver fibrosis - Hui Gong; Zhiqiang Fan; Dan Yi; Junyu Chen; Zuojun Li; Ren Guo; Chunjiang Wang; Weijin Fang; Shikun Liu (Journal of Molecular Histology, 2020)

RNA-seq analysis reveals divergent adaptive response to hyper- and hypo-salinity in cobia, Rachycentron canadum - Danyu Cao; Jinfeng Li; Baosong Huang; Jiandong Zhang; Chuanhao Pan; Jiansheng Huang; Hui Zhou; Qian Ma; Gang Chen; Zhongliang Wang (Fish Physiology and Biochemistry, 2020)

Identification of Cyt2Ba from a New Strain of Bacillus thuringiensis and Its Toxicity in Bradysia difformis - Fan-Fan Wang; Shao-Xuan Qu; Jin-Sheng Lin; Hui-Ping Li; Li-Juan Hou; Ning Jiang; Xin Luo; Lin Ma (Current Microbiology, 2020)
Bradysia difformis is one of the most damaging pests in mushroom production in China. In this study, eight Bacillus thuringiensis strains were analyzed for insecticidal activity in B. difformis . The strain JW-1 showed the highest insecticidal activity against B. difformis larvae, but did not inhibit the mycelial growth of Pleurotus ostreatus and P. geesteranus . The 16S rRNA gene (1397 bp) and cyt2 gene (792 bp) were obtained from strain JW-1. The phylogenetic tree based on 16S rRNA gene and Cyt2 toxin showed that strain JW-1 was a member of B. thuringiensis and Cyt2 toxin belonged to Cyt2Ba toxin cluster. The Cyt2Ba toxin from strain JW-1 was overexpressed in E. coli as a fusion protein and the fusion protein (70 kDa) was purified by Ni-IDA affinity chromatography. The purified Cyt2Ba fusion protein was toxic to B. difformis larvae (LC 50 was 2.25 ng/mL). The identification of Cyt2Ba from strain JW-1 and confirmation of the insecticidal activity of Cyt2Ba in B. difformis provided a new means of biological control of the important pest in mushroom production.

Sex Difference Between Trace Elements and Pulmonary Functions in Children - Zhenzhen Pan; Xiaojuan Zhang; Yu Hui; Hongxia Xiang; Qian Wang; Shiyao Xu; Ling Li (Biological Trace Element Research, 2020)

Comparison of mRNA Expression of P2X Receptor Subtypes in Different Arterial Tissues of Rats - Ling-Zhi Li; Li-Hui Yue; Zhi-Min Zhang; Jing Zhao; Lei-Ming Ren; Hong-Jie Wang; Lu Li (Biochemical Genetics, 2020)

Molecular characterization of an emerging reassortant mammalian orthoreovirus in China - Dandan Ye; Zhaoyang Ji; Hongyan Shi; Jianfei Chen; Da Shi; Liyan Cao; Jianbo Liu; Mingwei Li; Hui Dong; Zhaoyang Jing; Xiaobo Wang; Qiuge Liu; et al. (Archives of Virology, 2020)