The role of social networks in relocation induced by climate-related hazards: an empirical investigation in China - Jing Tan; Kui Zhou; Li Peng; Lei Lin (Climate and Development, 2022)

Identification of A-to-I RNA editing profiles and their clinical relevance in lung adenocarcinoma - Cheng Wang; Mingtao Huang; Congcong Chen; Yuancheng Li; Na Qin; Zijian Ma; Jingyi Fan; Linnan Gong; Hui Zeng; Liu Yang; Xianfeng Xu; Jun Zhou; et al. (Science China Life Sciences, 2022)

Efficacy and safety of aripiprazole once-monthly versus oral aripiprazole in Chinese patients with acute schizophrenia: a multicenter, randomized, double-blind, non-inferiority study - Le Xiao; Qian Zhao; An-ning Li; Jushui Sun; Bin Wu; Lina Wang; Honggeng Zhang; Ruiling Zhang; Keqing Li; Xiaojin Xu; Tiebang Liu; Wenshun Zhang; et al. (Psychopharmacology, 2022)

Comparison of the effects of three fungicides on clubroot disease of tumorous stem mustard and soil bacterial community - Jingjing Liao; Luyun Luo; Li Zhang; Lingzhi Wang; Xuedan Shi; Hao Yang; Shenghua Tan; Lei Tan; Xin Liu; Diandong Wang; Zhenchuan Mao (Journal of Soils and Sediments, 2022)
Purpose The application of fungicides is one of the main strategies to prevent clubroot disease. Currently, numerous studies focus on changes in the soil microbial community at different levels of clubroot disease severity. However, the effects of fungicides on the soil microbial community and causative pathogen, Plasmodiophora brassicae , while preventing clubroot disease remain unclear. Methods In this study, we evaluated the control efficacy of three fungicides (fluazinam, metalaxyl-mancozeb, and carbendazim) on clubroot disease of tumorous stem mustard in greenhouse experiment. Uninoculated and Water treatments after inoculation were performed as controls. At three (3 W) and six weeks (6 W) post-inoculation of P. brassicae , soil properties, bacterial composition (sequencing of 16S rRNA genes), and effector gene expression of the pathogen were analyzed. The correlation of these factors with disease index (DI) was explored. Results Fluazinam was the most effective in controlling clubroot disease of tumorous stem mustard with a controlled efficacy of 59.81%, and the abundance of P. brassicae in the soil decreased 21.29% after 3 weeks of treatment. Compared with other treatments, twelve out of twenty effector genes showed higher expression in fluazinam 3 W samples. Different fungicides had different effects on soil properties. EC (electrical conductivity), the main factor that positively associated with DI, was significantly lower in fluazinam treatment than the other two fungicide treatments. The application of fungicides, especially carbendazim, significantly reduced bacterial α-diversity and the composition of soil bacteria. Pseudomonas , Microbacterium , and Sphingobacterium (positively correlated with DI) were enriched in Water, metalaxyl-mancozeb, and carbendazim treatments, but were less abundant in fluazinam treatment. Among the three fungicide treatments, DI was significantly negatively correlated with Shannon and Chao 1 indices. Soil properties and the top bacterial genera that positively correlated with DI were influenced to a lesser degree in the fluazinam treatment. Conclusion Among three fungicides, fluazinam was the most effective agent with the highest control effects against clubroot disease. The strong virulence of fluazinam against P. brassicae was one of the main reasons for the prevention of clubroot disease, and in addition the alteration of rhizosphere bacterial community by fluazinam to the detriment of P. brassicae infection. Based on our results, EC could be an indicator of the severity of clubroot disease.

Synthesis, characterization, and antioxidant activity of carboxymethyl chitosan derivatives containing sulfonium salt - Xueqi Sun; Jingjing Zhang; Yingqi Mi; Qin Miao; Wenqiang Tan; Qing Li; Zhanyong Guo (Journal of Oceanology and Limnology, 2022)

Metabolomics provide insights into the endogenous mechanism of strobilation in the scyphozoan jellyfish Rhopilema esculentum - Jianlong Ge; Xiaohui Chen; Changlin Liu; Jie Tan; Li Bian; Lifei Chen; Siqing Chen (Journal of Oceanology and Limnology, 2022)

N-acetylcysteine alleviates pulmonary inflammatory response during benzo[a]pyrene-evoked acute lung injury - Hui Zhao; Lin Fu; Hui-Xian Xiang; Ying Xiang; Meng-Die Li; Bian-Bian Lv; Zhu-Xia Tan; Lan Gao; Cheng Zhang; De-Xiang Xu (Environmental Science and Pollution Research, 2022)

Sodium arsenite-mediated upregulation of circDHX34 promotes apoptosis in hormone-independent breast cancer cells by regulating apoptotic genes - Shuting Li; Chenglan Jiang; Jingwen Tan; Qian Zhou; Jinyao Yin; Yuefeng He (Environmental Science and Pollution Research, 2022)

Release of the additive metals from 3 commonly used plastics during the degradation under the treatment of UV irradiation - Wenhua Feng; Canjie Huang; Xiangling Tan; Nian Tang; Lulu Zhang; Hengxiang Li; Xiangrong Xu; Jinping Peng (Ecotoxicology, 2022)

Different changes in pre- and postsynaptic components in the hippocampal CA1 subfield after transient global cerebral ischemia - Yan Zhang; Bai-Hong Tan; Shuang Wu; Cheng-Hao Wu; Jia-Le Suo; Yue Gui; Cheng-Mei Zhou; Yan-Chao Li (Brain Structure and Function, 2022)

The origin and source of natural gas in the Lower Permian in Hewanchang area, Northwest Sichuan - Kaijun Tan; Yaoting Li; Jianbo Liao; Zhiming Xu; Zhanghao Liu; Zonghui Lin (Arabian Journal of Geosciences, 2022)

Oceanic crustal structure and tectonic origin of the southern Kyushu-Palau Ridge in the Philippine Sea - Xiongwei Niu; Pingchuan Tan; Weiwei Ding; Wei Wang; Yao Wei; Xiaodong Wei; Aiguo Ruan; Jie Zhang; Chunyang Wang; Yong Tang; Jiabiao Li (Acta Oceanologica Sinica, 2022)

Relationship between the interannual and intraseasonal temperature variability in Northeast China - Wenhui Li; Guirong Tan; Tim Li (International Journal of Climatology, 2022)
A significant negative correlation between the seasonal mean temperature anomaly and the intensity of the intraseasonal temperature oscillation in the northern winter over Northeast China is found during the time period 1959–2011. A stronger intraseasonal oscillation (ISO) is found during an extremely cold winter. The cold winter in Northeast China is a part of zonally oriented large‐scale pattern with a negative (positive) temperature anomaly in mid‐ (high) latitudes and is associated with a negative phase of the North Atlantic Oscillation (NAO). The intraseasonal temperature anomaly originates from high‐latitude Central Eurasia and propagates southeastward. The southeastward propagation is attributed to the upper tropospheric dispersion of Rossby wave energy as a result of coupling of the low‐level temperature and the upper‐level geopotential height. The cause of the negative correlation between the intraseasonal and interannual modes is investigated. A cold winter in Northeast China is associated with a weakened meridional temperature gradient and vertical wind shear north of 50°N. This weakens synoptic variability in situ through baroclinic instability. Because the ISO competes for an energy source with the synoptic motion, the ISO is enhanced north of 50°N. The southeastward propagation of the enhanced ISO mode increased intraseasonal temperature variability over Northeast China. As a result, a cold winter in Northeast China is accompanied by an enhanced ISO variability in situ. The enhanced local ISO could further feedback to the winter mean temperature anomaly through nonlinear advective processes. The diagnosis of the temperature budget indicates that the ISO may interact with motion on other scales to contribute to the winter mean temperature anomaly in situ.

Two new bioactive polyphenols from the soft coral-derived fungus Talaromyces sp. SCSIO 041201 - Ji-xing Li; Xin-xin Lei; Yan-hong Tan; Yong-hong Liu; Bin Yang; Yun-qiu Li (Natural Product Research, 2021)

An innovative echo detection system with STM32 gated and PMT adjustable gain for airborne LiDAR - Guoqing Zhou; Weihao Li; Xiang Zhou; Yizhi Tan; Gangchao Lin; Xianxing Li; Ronghua Deng (International Journal of Remote Sensing, 2021)

Economic Evaluation of Water-Saving Irrigation Practices for Sustainable Sugarcane Production in Guangxi Province, China - Shan-Shan He; Yuan Zeng; Zhao-Xu Liang; Yan Jing; ShiYun Tang; Baoqing Zhang; Haifeng Yan; Song Li; Tinglin Xie; Fang Tan; Ming Li (Sugar Tech, 2021)

A Novel Approach to Surface Strain Measurement for Cylindrical Rock Specimens Under Uniaxial Compression Using Distributed Fibre Optic Sensor Technology - Shao-Qun Lin; Dao-Yuan Tan; Jian-Hua Yin; Hua Li (Rock Mechanics and Rock Engineering, 2021)

3D Observations of Fracturing in Rock-Backfill Composite Specimens Under Triaxial Loading - Xin Yu; John Kemeny; Jialuo Li; Weidong Song; Yuye Tan (Rock Mechanics and Rock Engineering, 2021)

Correction to: NLK is a key regulator of proliferation and migration in gallbladder carcinoma cells - Zhujun Tan; Maolan Li; Wenguang Wu; Lin Zhang; Qichen Ding; Xiangsong Wu; Jiasheng Mu; Yingbin Liu (Molecular and Cellular Biochemistry, 2021)

ERα promotes transcription of tumor suppressor gene ApoA-I by establishing H3K27ac-enriched chromatin microenvironment in breast cancer cells - Bingjie Wang; Yinghui Shen; Tianyu Liu; Li Tan (Journal of Zhejiang University-SCIENCE B, 2021)

3D printing of bioinspired compartmentalized capsular structure for controlled drug release - Jingwen Li; Mingxin Wu; Wenhui Chen; Haiyang Liu; Di Tan; Shengnan Shen; Yifeng Lei; Longjian Xue (Journal of Zhejiang University-SCIENCE B, 2021)

Analysis of the current activity of the Red River fault based on GPS data: new seismological inferences - XiaoFei Lu; Kai Tan; Qi Li; Chengtao Li; Dongzhen Wang; Caihong Zhang (Journal of Seismology, 2021)

Study on Physicochemical Properties of High-Density Sludge Sediment in Copper Mine After Phytoremediation - Ruoyan Cai; Jinchun Xue; Li Tan; Zhuyu Zhao; Zhaoyang Zhang (Journal of Soil Science and Plant Nutrition, 2021)

Overview of Air Pollution in Typical Basin of China Under the Target of Carbon Neutrality - Xiaoju Li; Luqman Chuah Abdullah; Shafreeza Sobri; Mohamad Syazarudin Md Said; Siti Aslina Hussain; Tan Poh Aun (International Journal of Environmental Research, 2021)

External evaluation of published population pharmacokinetic models of polymyxin B - Ya-qian Li; Kai-feng Chen; Jun-jie Ding; Hong-yi Tan; Nan Yang; Ya-qi Lin; Cui-fang Wu; Yue-liang Xie; Guo-ping Yang; Jing-Jing Liu; Qi Pei (European Journal of Clinical Pharmacology, 2021)

Pharmacodynamic effects of indobufen compared with aspirin in patients with coronary atherosclerosis - Mingwen Yang; Zekang Ye; Lianlian Mei; Inam Ullah; Chuchu Tan; Guoyu Wang; Qian Gu; Yi Lu; Samee Abdus; Lu Shi; Xiaoxuan Gong; Jianling Bai; et al. (European Journal of Clinical Pharmacology, 2021)

Dissimilatory nitrate reduction and functional genes in two subtropical rivers, China - Binjie Zhao; Xinshuai Li; Yang Wang; Xiang Tan; Wenhua Qi; Hongran Li; Junwei Wei; Yong You; Wenjun Shi; Quanfa Zhang (Environmental Science and Pollution Research, 2021)

All around suboptimal health — a joint position paper of the Suboptimal Health Study Consortium and European Association for Predictive, Preventive and Personalised Medicine - Wei Wang; Yuxiang Yan; Zheng Guo; Haifeng Hou; Monique Garcia; Xuerui Tan; Enoch Odame Anto; Gehendra Mahara; Yulu Zheng; Bo Li; Timothy Kang; Zhaohua Zhong; et al. (EPMA Journal, 2021)
First two decades of the twenty-first century are characterised by epidemics of non-communicable diseases such as many hundreds of millions of patients diagnosed with cardiovascular diseases and the type 2 diabetes mellitus, breast, lung, liver and prostate malignancies, neurological, sleep, mood and eye disorders, amongst others. Consequent socio-economic burden is tremendous. Unprecedented decrease in age of maladaptive individuals has been reported. The absolute majority of expanding non-communicable disorders carry a chronic character, over a couple of years progressing from reversible suboptimal health conditions to irreversible severe pathologies and cascading collateral complications. The time-frame between onset of SHS and clinical manifestation of associated disorders is the operational area for an application of reliable risk assessment tools and predictive diagnostics followed by the cost-effective targeted prevention and treatments tailored to the person. This article demonstrates advanced strategies in bio/medical sciences and healthcare focused on suboptimal health conditions in the frame-work of Predictive, Preventive and Personalised Medicine (3PM/PPPM). Potential benefits in healthcare systems and for society at large include but are not restricted to an improved life-quality of major populations and socio-economical groups, advanced professionalism of healthcare-givers and sustainable healthcare economy. Amongst others, following medical areas are proposed to strongly benefit from PPPM strategies applied to the identification and treatment of suboptimal health conditions: Stress overload associated pathologies Male and female health Planned pregnancies Periodontal health Eye disorders Inflammatory disorders, wound healing and pain management with associated complications Metabolic disorders and suboptimal body weight Cardiovascular pathologies Cancers Stroke, particularly of unknown aetiology and in young individuals Sleep medicine Sports medicine Improved individual outcomes under pandemic conditions such as COVID-19.

Emission Reduction Efficiency Analysis Based on Characteristics of Vehicle Emissions - Yi Xu; Yujiao Hao; Tongqing Zhang; Wei Yan; Yuqiong Wang; Dong Guo; Xiaochuan Tan; Xingbang Gao; Jiaojiao Li (Emission Control Science and Technology, 2021)

Dinoflagellate-targeted PCR reveals highly abundant and diverse communities of parasitic dinoflagellates in and near Zhubi Reef, South China Sea - Dajun Qiu; Liangmin Huang; Yunyun Zhuang; Yu Zhong; Yuehui Tan; Xiubao Li; Sheng Liu; Hui Huang; Senjie Lin (Coral Reefs, 2021)

Enhanced ATP and antioxidant levels for cAMP biosynthesis by Arthrobacter sp. CCTCC 2013431 with polyphosphate addition - Zhigang Li; Hai Tan; Nanxun Lu; Zhonghua Zhang; Jingling Chang (Biotechnology Letters, 2021)

Overexpression of an aquaporin protein from Aspergillus glaucus confers salt tolerance in transgenic soybean - Feiwu Li; Hejia Ni; Wei Yan; Yanbo Xie; Xiaodan Liu; Xichang Tan; Ling Zhang; Shi-Hong Zhang (Transgenic Research, 2021)

Characteristics and formation mechanism of siltstone-mudstone rhythmic sedimentary sections in the Lower Silurian Longmaxi Formation in the Changning area, South Sichuan Basin, southwest China - Gaoxiang Wang; Lei Chen; Yang Yang; Cui Jing; Man Chen; Xiucheng Tan; Xin Chen; Di Cao; Zibo Wei; Minglong Li; Dong Huang (Frontiers of Earth Science, 2021)

Complete genome sequence of a novel mitovirus associated with Lagenaria siceraria - Xia Chen; Du Hai; Jincang Li; Jie Tan; Shuping Huang; Hongyuan Zhang; Hao Chen; Min Zhang (Archives of Virology, 2021)

Numerical simulation study on the influence of crack characteristics on mechanical properties and impact failure of rock - Tan Li; Guangbo Chen; Zhongcheng Qin; Qinghai Li; Yanhui Li (Arabian Journal of Geosciences, 2021)

Research on support method in soft rock tunnel considering the rheological characteristics of rock - Xiao-long Guo; Yong-quan Zhu; Zhong-sheng Tan; Lei Li; Ang Li; Ya-tao Yan (Arabian Journal of Geosciences, 2021)

Intelligent fish farm—the future of aquaculture - Cong Wang; Zhen Li; Tan Wang; Xianbao Xu; Xiaoshuan Zhang; Daoliang Li (Aquaculture International, 2021)

Early neutrophil-to-lymphocyte ratio is a prognostic marker in acute minor stroke or transient ischemic attack - Yi Luo; Lie-xin Xia; Zhi-lian Li; Ding-fang Pi; Xian-pei Tan; Qiang Tu (Acta Neurologica Belgica, 2021)

Environmental contamination with SARS‐CoV ‐2 in COVID ‐19 hospitals in Wuhan, China, 2020 - Wei Liu; Dingchen Li; Chaojie Yang; Fangyan Chen; Ruizhong Jia; Leili Jia; Xinyi Xia; Shanhong Fan; Qing Tan; Yuehua Ke; Yong Chen; Haifeng Li; et al. (Environmental Microbiology, 2021)
Summary Coronavirus disease 2019 (COVID‐19) pandemic has caused high number of infections and deaths of healthcare workers globally. Distribution and possible transmission route of SARS‐CoV‐2 in hospital environment should be clarified. We herein collected 431 environmental (391 surface and 40 air) samples in the intensive care unit (ICU) and general wards (GWs) of three hospitals in Wuhan, China from February 21 to March 4, 2020, and detected SARS‐CoV‐2 RNA by real‐time quantitative PCR. The viral positive rate in the contaminated areas was 17.8% (28/157), whereas there was no virus detected in the clean areas. Higher positive rate (22/59, 37.3%) was found in ICU than that in GWs (3/63, 4.8%). The surfaces of computer keyboards and mouse in the ICU were the most contaminated (8/10, 80.0%), followed by the ground (6/9, 66.7%) and outer glove (2/5, 40.0%). From 17 air samples in the contaminated areas, only one sample collected at a distance of around 30 cm from the patient was positive. Enhanced surface disinfection and hand hygiene effectively decontaminated the virus from the environment. This finding might help understand the transmission route and contamination risk of SARS‐CoV‐2 and evaluate the effectiveness of infection prevention and control measures in healthcare facilities.

Photobleaching and Recovery of Symbiodiniaceae Effrenium voratum SCS01 Reveals Life Form Transformation Under Thermal Stress - Sanqiang Gong; Gang Li; Xuejie Jin; Dajun Qiu; Jiayuan Liang; Kefu Yu; Yehui Tan; Xiao Ma; Xiaomin Xia (Frontiers in Marine Science, 2021)
Dinoflagellates in the family Symbiodiniaceae contain a number of species and play an important role in the establishment of coral reef ecosystems in oligotrophic marine waters. Effrenium voratum is likely an exclusively free-living and heterotrophic species of Symbiodiniaceae. How this species responds and acclimates to warming is largely unknown. The present study experimentally established the phenotypic landscapes related to the photobleaching and recovery processes of Effrenium voratum SCS01 following thermal stress. We found that thermal stress bleached the plastids of E. voratum SCS01 and caused the cells to become lighter in color. Thereafter, the bleached cells recovered rapidly when they returned to the optimal temperature. The dominant life form of E. voratum SCS01 shifted from mastigote cells to coccoid cells then returned to mastigote cells. Transcriptome analysis revealed that the photobleaching of E. voratum SCS01 was due to increased degradation and decreased biosynthesis of photosynthetic pigments. The thermally induced life form changes were related to the downregulation of genes for cell motility. Our results revealed the mechanism of photobleaching in E. voratum SCS01 and indicated life form transformation as a newly identified survival strategy of Effrenium voratum SCS01 under thermal stress.

The Effect of Oxidized Fish Oil on the Spleen Index, Antioxidant Activity, Histology and Transcriptome in Juvenile Hybrid Grouper (♀ Epinephelus fuscoguttatus × ♂ Epinephelus lanceolatus) - Shuisheng Long; Zhihao Li; Xiaohui Dong; Xiaobo Yan; Hao Liu; Beiping Tan; Shuang Zhang; Simiao Pan; Tao Li; Xiangxiang Suo; Yuanzhi Yang (Frontiers in Marine Science, 2021)
The spleen is an important organ in the immune function of fish, and it is also important for hematogenesis and antibody and granulocyte production. However, the effect of oxidized fish oil on the spleen of hybrid grouper (♀ Epinephelus fuscoguttatus × ♂ Epinephelus lanceolatus ) is unknown. In this study, hybrid groupers were fed with oxidized fish oil and the spleen index, antioxidant ability, histology and transcriptome were investigated. Oxidized fish oil did not affect the spleen index. Levels of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px) and malondialdehyde (MDA) in the spleen were significantly increased as the amount of oxidized fish oil in the diet increased, but the vitamin E concentration was significantly decreased. The morphological organization of the spleen was damaged with increased oxidative stress. And the spleen reacted to oxidative stress by platelet activation, FOXO and notch signaling pathways, which involved amyloid beta precursor protein binding family B member 1 interacting protein (APBB1IP) gene, glucose-6-phosphatase (G6PC) gene, histone acetyltransferase p300 (EP300) gene, insulin gene and notch 2 gene. In conclusion, the oxidized fish oil caused oxidative stress and damaged its structure. Additionally, oxidized fish oil changed the transcription profile of the spleen.

Contrasting Early Palaeozoic provenance of the Yemaquan and Harlik arcs in the SW Altaids (NW China): identification of cryptic sutures in accretionary orogens - Liang Li; Wenjiao Xiao; Brian F. Windley; Qigui Mao; Xiaoliang Jia; He Yang; Zhou Tan; Miao Sang; Jingmin Gan; Nijiati Abuduxun (International Geology Review, 2021)

Three new ester glycosides with cytotoxic activity from the seeds of Caesalpinia sappan - Min Wang; Juan Tan; Jun Chen; Tian Xie; Liang-Mo Lin; Li-Li Zhong; Xing-Jun Cai; Qiong-Shi Wu (Natural Product Research, 2021)

Cytotoxic triterpenoid glycosides from leaves of Cyclocarya paliurus - Hui-Hui Sun; Wen-Yan Lv; Jie Tan; Yu-Cheng Tang; Hui Zhu; Jian-Bo Qu; Jing Li; Jian-Ping Wu; Xi-Wen Chang; Zhi-Chun Yang; Wen-Xuan Wang; Zu-Hui Chen; et al. (Natural Product Research, 2021)

Two new nor-sesquiterpenoids from Fusarium tricinctum , an endophytic fungus isolated from Ligusticum chuanxiong - Yu-Mei Cao; Da-Le Guo; Meng-Ying Jin; Lu Tan; Tian-Long Yang; Fang Deng; Yu-Cheng Gu; Xiao-Hua Li; Zhi-Xing Cao; Yun Deng (Natural Product Research, 2021)

Carbon, oxygen and strontium isotopes of the Mesoproterozoic Jixian System （1.6-1.4 Ga）in the southern margin of the North China Craton and the geological implications - Cong Tan; Yuanzheng Lu; Xin Li; Haonan Song; Dan Lv; Xueying Ma; Ru Fan; Shenghui Deng (International Geology Review, 2021)

Molecular mechanism of mureidomycin biosynthesis activated by introduction of an exogenous regulatory gene ssaA into Streptomyces roseosporus - Ning Liu; Hanye Guan; Guoqing Niu; Lingjuan Jiang; Yue Li; Jihui Zhang; Jine Li; Huarong Tan (Science China Life Sciences, 2021)

Physiological response of moss/cyanobacteria crusts along a precipitation gradient from semi-arid to arid desert in China - Rong Hui; Xinrong Li; Ruiming Zhao; Huijuan Tan; Rongliang Jia (Plant and Soil, 2021)

Retraction Note to: Deoxynivalenol-induced alterations in the redox status of HepG2 cells: identification of lipid hydroperoxides, the role of Nrf2-Keap1 signaling, and protective effects of zinc - Wageh Sobhy Darwish; Zhen Chen; Yonghan Li; Hui Tan; Hitoshi Chiba; Shu-Ping Hui (Mycotoxin Research, 2021)

The Role of TMEM16A/ERK/NK-1 Signaling in Dorsal Root Ganglia Neurons in the Development of Neuropathic Pain Induced by Spared Nerve Injury (SNI) - Qinyi Chen; Liangjingyuan Kong; Zhenzhen Xu; Nan Cao; Xuechun Tang; Ruijuan Gao; Jingrong Zhang; Shiyu Deng; Chaoyang Tan; Meng Zhang; Yang Wang; Liang Zhang; et al. (Molecular Neurobiology, 2021)
Increasing evidence suggests that transmembrane protein 16A (TMEM16A) in nociceptive neurons is an important molecular component contributing to peripheral pain transduction. The present study aimed to evaluate the role and mechanism of TMEM16A in chronic nociceptive responses elicited by spared nerve injury (SNI). In this study, SNI was used to induce neuropathic pain. Drugs were administered intrathecally. The expression and cellular localization of TMEM16A, the ERK pathway, and NK-1 in the dorsal root ganglion (DRG) were detected by western blot and immunofluorescence. Behavioral tests were used to evaluate the role of TMEM16A and p-ERK in SNI-induced persistent pain and hypersensitivity. The role of TMEM16A in the hyperexcitability of primary nociceptor neurons was assessed by electrophysiological recording. The results show that TMEM16A, p-ERK, and NK-1 are predominantly expressed in small neurons associated with nociceptive sensation. TMEM16A is colocalized with p-ERK/NK-1 in DRG. TMEM16A, the MEK/ERK pathway, and NK-1 are activated in DRG after SNI. ERK inhibitor or TMEM16A antagonist prevents SNI-induced allodynia. ERK and NK-1 are downstream of TMEM16A activation. Electrophysiological recording showed that CaCC current increases and intrathecal application of T16Ainh-A01, a selective TMEM16A inhibitor, reverses the hyperexcitability of DRG neurons harvested from rats after SNI. We conclude that TMEM16A activation in DRG leads to a positive interaction of the ERK pathway with activation of NK-1 production and is involved in the development of neuropathic pain after SNI. Also, the blockade of TMEM16A or inhibition of the downstream ERK pathway or NK-1 upregulation may prevent the development of neuropathic pain.

Impacts of ecological restoration on public perceptions of cultural ecosystem services - Qingyue Tan; Chen Gong; Shujie Li; Ning Ma; Fengchi Ge; Mingxiang Xu (Environmental Science and Pollution Research, 2021)

Comparative genomic analysis of Mycoplasma anatis strains - Qi Zhou; Kaijie Mai; Dehong Yang; Junfa Liu; Zhuanqiang Yan; Cuifen Luo; Yangtong Tan; Sheng Cao; Qingfeng Zhou; Li Chen; Feng Chen (Genes & Genomics, 2021)

Resonance Control Based on Hydrodynamic Analysis for Underwater Direct Drive Wave Energy Converter - Yang Li; Lei Huang; Peiwen Tan; Minshuo Chen; Junquan Chen (Journal of Marine Science and Engineering, 2021)
Wave energy has great prospect among many forms of marine renewable energy for its high density and storage. This paper proposes an underwater direct drive wave energy converter (UDDWEC), which is composed of a submerged point absorbing buoy and a linear-rotating axial flux permanent magnetic generator (LR-AFPMG). In addition, a maximum energy capture control strategy, resonance control, is derived for UDDWEC, based on small amplitude oscillation and hydrodynamic analysis. The proposed control strategy assumes the availability of sea condition such as wave height and period. This control strategy has three main characteristics. Firstly, this control strategy is derived based on hydrodynamic analysis of the submerged point absorber. Added mass, radiation damping and other hydrodynamic parameters are obtained to participate in UDDWEC dynamic model. Secondly, a LR-AFPMG is applied as power take-off device to realize energy conversion, which can improve the power density. Thirdly, small amplitude oscillation can be changed into long stroke rotary motion through the LR-AFPMG. The reliability and effectiveness of the proposed control strategy are assessed at various operation conditions for a heaving system and the validity for the UDDWEC is verified.

Two new biflavanoids from Selaginella trichoclada Alsto - Yang Xie; Ping-Sheng Xu; Kang-Ping Xu; Zhen-Xing Zou; Gan Zhou; Dai Li; Dan Li; Xiao-Min Li; Jing Li; Gui-Shan Tan (Natural Product Research, 2021)

A widespread response of Gram-negative bacterial acyl-homoserine lactone receptors to Gram-positive Streptomyces γ-butyrolactone signaling molecules - Xiang Liu; Wenxi Wang; Junyue Li; Yue Li; Jihui Zhang; Huarong Tan (Science China Life Sciences, 2021)

The functional analysis of transiently upregulated miR-101 suggests a “braking” regulatory mechanism during myogenesis - Shurong Liu; Shujuan Xie; Huafeng Chen; Bin Li; Zhirong Chen; Yeya Tan; Jianhua Yang; Lingling Zheng; Zhendong Xiao; Qi Zhang; Lianghu Qu (Science China Life Sciences, 2021)

Downregulation of fibronectin 1 attenuates ATRA-induced inhibition of cell migration and invasion in neuroblastoma cells - Xiaolin Tan; Wei Gong; Bo Chen; Baocheng Gong; Zhongyan Hua; Simeng Zhang; Yang Chen; Qi Li; Zhijie Li (Molecular and Cellular Biochemistry, 2021)

RNA-seq analysis of ischemia stroke and normal brain in a tree shrew model with or without type 2 diabetes mellitus - Ling Zhao; Shiying Huang; Qiwei Liao; Xia Li; Shufen Tan; Shuqing Li; Tingyu Ke (Metabolic Brain Disease, 2021)

Additive and Epistatic QTL on Cadmium (Cd) Tolerance Associated with Seed Germinating Ability in Rice - Changsheng Li; Peng Wang; Guangliang Wu; Yanning Wang; Qin Cheng; Yicong Cai; Dahu Zhou; Caijing Li; Xiangyu Zhang; Jingai Tan; Cuijuan Li; Haohua He; et al. (Journal of Plant Growth Regulation, 2021)

Predisposition to Graves’ disease and Graves’ ophthalmopathy by genetic variants of IL2RA - Juan Du; Xin Wang; Guiqin Tan; Wenwen Wei; Fangyu Zhou; Zhongzhi Liang; Hua Li; Hongsong Yu (Journal of Molecular Medicine, 2021)

FDwave3D: a MATLAB solver for the 3D anisotropic wave equation using the finite-difference method - Lei Li; Jingqiang Tan; Dazhou Zhang; Ajay Malkoti; Ivan Abakumov; Yujiang Xie (Computational Geosciences, 2021)

TRIM25 Rescues Against Doxorubicin-Induced Pyroptosis Through Promoting NLRP1 Ubiquitination - Xiaxia Wang; Zhexun Lian; Yiping Ge; Dongqiang Yu; Shan Li; Kai Tan (Cardiovascular Toxicology, 2021)

Enhanced endogenous amino acids and energy metabolism level for cAMP biosynthesis by Arthrobacter sp. CCTCC 2013431 with citrate as cosubstrate - Zhigang Li; Baofeng Chen; Yang Gu; Hai Tan; Zhonghua Zhang; Jingling Chang (Biotechnology Letters, 2021)

Comet Assay Evaluation of Lanthanum Nitrate DNA Damage in C57-ras Transgenic Mice - Gaochao Han; Zhuangsheng Tan; Haiming Jing; Junyu Ning; Zinan Li; Shan Gao; Guojun Li (Biological Trace Element Research, 2021)

Procyanidin inhibited N2O emissions from paddy soils by affecting nitrate reductase activity and nirS- and nirK-denitrifier populations - Mujun Ye; Chang Yin; Xiaoping Fan; Zixiang Gao; Hao Chen; Li Tan; Scott X. Chang; Yuhua Zhao; Yongchao Liang (Biology and Fertility of Soils, 2021)

Application of single-sperm sequencing in a male with Marfan syndrome: a case report and a literature review - Chuang Li; Feifei Zhou; Jichun Tan; Yan Mao; Ling-Yin Kong; Yan Zhao; Yan Zhang; Bo Liang; Jesse Li-Ling; Caixia Liu; Yuan Lyu (Journal of Genetics, 2021)

Tumor suppressive effect of scavenger receptor class A member 5 overexpression in colorectal cancer by regulating PI3K/AKT/mTOR pathway - Yi Li; Feng Peng; Xiangyun Tan; Jin Wang; Yeqing Xu (Genes & Genomics, 2021)
Background Colorectal cancer (CRC) exhibits high risks of morbidity and mortality. Objective To investigate the effect of scavenger receptor class A member 5 (SCRAR5) on CRC and its mechanism on modulation of cancer development. Methods The SCRAR5 expression in four kinds of CRC cell lines (SW620, SW480, HT29, and HCT116) was measured by quantitative PCR and western blotting, respectively. The effects of SCRAR5 abnormal expression on cell proliferation, apoptosis, and migration were analyzed by CCK-8 assay, EdU assay, colony-forming assay, flow cytometry assay, Transwell assay and wound healing assay, respectively. Meanwhile, the involvements of PI3K/AKT/mTOR pathway with the role of SCRAR5 were investigated by western blotting. Afterwards, the in vivo effects of SCRAR5 abnormal expression on CRC xenograft mice were finally investigated by evaluating tumor volume, apoptosis and Ki67 expression. Results SCRAR5 was lowly expressed in CRC cell lines, especially SW480 cells. Up-regulation of SCRAR5 significantly promoted cell apoptosis, reduced cell proliferation and migration in SW480 cells. Notably, SCRAR5 overexpression obviously inhibited the phosphorylation levels of PI3K, AKT, and mTOR. Reversely, SCRAR5 silence exhibited promoting effects on HT29 cells. Consistently, in vivo experiments also revealed that SCRAR5 overexpression remarkably suppressed tumor volume and Ki67 expression, as well as promoted cell apoptosis. Conclusions Overall, up-regulating of SCRAR5 obviously inhibited CRC tumor growth in vitro and in vivo, which might be related to PI3K/AKT/mTOR pathway.

The glycosyltransferase ST3GAL2 modulates virus proliferation and the inflammation response in porcine reproductive and respiratory syndrome virus infection - Xiaoyang Li; Yanyu Guo; Yinna Song; Ruiqi Sun; Min Zhu; Zheng Tan; Umm E Swaiba; Lilin Zhang; Jinhai Huang (Archives of Virology, 2021)

Decreasing Biological Production and Carbon Export Due to the Barrier Layer: A Case Study in the Bay of Bengal - Huangchen Zhang; Linbin Zhou; Kaizhi Li; Zhixin Ke; Yehui Tan (Frontiers in Marine Science, 2021)
A freshwater-induced barrier layer (BL) is a common physical phenomenon both in coastal waters and the open ocean. To examine the effects of BL on the biological production and the associated carbon export, a physical-biogeochemical survey was conducted in the Bay of Bengal. Severe depletions of surface phosphorus and the deepening of the nutricline were observed at the BL-affected stations due to the vertical mixing prohibition. The lowered surface chlorophyll a (Chl a ) and squeezed deep Chl a maximum (DCM) layer also resulted in the ~18% lowered vertically integrated Chl a at the said stations. The composition of the net-sampled zooplankton was altered, and the abundance decreased by half at the BL-affected station (29.68 ind. m −3 ) compared with the unaffected station (55.52 ind. m −3 ). Such reductions in major zooplankton groups were confirmed by a video plankton recorder (VPR). The VPR observation indicated that there was a lower (by one-half) abundance of detritus at the BL-affected station, while the much lower carbon export flux rates were estimated to be at the BL-affected station (0.31 mg C m −2 d −1 ) rather than the unaffected station (0.77 mg C m −2 d −1 ). An idealized one-dimensional nutrient-phytoplankton-detritus model identified that the existence of BL can lead to decreased surface nutrients and phytoplankton concentrations, squeezed DCM layers, and lower detritus abundances. Finally, this study indicated that BL layers inhibit biological production and reduce carbon export, thus playing an important role in the ocean biogeochemical cycles.

Genomic structural equation modelling provides a whole-system approach for the future crop breeding - Tianhua He; Tefera Tolera Angessa; Camilla Beate Hill; Xiao-Qi Zhang; Kefei Chen; Hao Luo; Yonggang Wang; Sakura D. Karunarathne; Gaofeng Zhou; Cong Tan; Penghao Wang; Sharon Westcott; et al. (Theoretical and Applied Genetics, 2021)

Fine mapping of Ne1, the hybrid necrosis gene complementary to Ne2 in common wheat (Triticum aestivum L.) - Na Li; Qiuyi Tan; Jinhua Ding; Xinglai Pan; Zhengqiang Ma (Theoretical and Applied Genetics, 2021)

TBM Cutter Wear Under High-Strength Surrounding Rock Conditions: A Case Study from the Second Phase of the Northern Xinjiang Water Supply Project - Zhengliang Zhou; Zhongsheng Tan; Zonglin Li; Dong Ma; Lilong Zhang (Rock Mechanics and Rock Engineering, 2021)

Correlations between Dual-Pathway White Matter Alterations and Language Impairment in Patients with Aphasia: A Systematic Review and Meta-analysis - Jie Zhang; Shuchang Zhong; Liang Zhou; Yamei Yu; Xufei Tan; Min Wu; Peng Sun; Wei Zhang; Juebao Li; Ruidong Cheng; Yanfei Wu; Yanmei Yu; et al. (Neuropsychology Review, 2021)

Short-term effect of manure and straw application on bacterial and fungal community compositions and abundances in an acidic paddy soil - Haiyang Liu; Wei Xu; Jiangye Li; Zhuyun Yu; Quanchao Zeng; Wenfeng Tan; Wentian Mi (Journal of Soils and Sediments, 2021)

Silurian to early Permian slab melting and crustal growth in the southern Altaids: insights from adakites and associated mineral deposits in the Dananhu arc, Eastern Tianshan, NW China - Qigui Mao; Songjian Ao; Dongfang Song; Wenjiao Xiao; Brian F. Windley; Miao Sang; Zhou Tan; Hao Wang; Rui Li (International Journal of Earth Sciences, 2021)

Identification of QTL for resistance to head smut in maize (Zea mays. L) - Hongbo Qiu; Kang Tan; Chunhong Li; Tao Shen; Zhi Zhang (Euphytica, 2021)

Determination of imidacloprid and acetamiprid in bottled juice by a new DLLME-HPLC - Janar Tursen; Ting Yang; Lu Bai; Deqiang Li; Ruikang Tan (Environmental Science and Pollution Research, 2021)

Revalidation of temperature changes on economic impacts: a meta-analysis - Ling Tan; Kun Zhou; Hui Zheng; Lianshui Li (Climatic Change, 2021)

Reliability parameter back analysis of bedding rock slope with multi-layer slide surfaces - Shi Zuo; Lianheng Zhao; Hanhua Tan; Liang Li; Dongping Deng; Zhichen Song (Bulletin of Engineering Geology and the Environment, 2021)

Baicalin attenuates adriamycin-induced nephrotic syndrome by regulating fibrosis procession and inflammatory reaction - Ning Tan; Chen-Xia Sun; Hui-Jun Zhu; De-Yu Li; Sheng-Guang Huang; Shou-Di He (Genes & Genomics, 2021)

Influencing factors and physiochemical changes of embryogenesis through in vitro isolated microspore culture in Brassica species - Yan-Qi Dong; Yu-Hong Gao; Te Zhao; Guang-Qian Ren; Yan-Li Liu; Bin Guan; Rong-Xian Jin; Fei Gao; Yan-Li Zhang; Xiu-Fang Tan; Hong-Cai Zhu; Yu-Hong Zhang; et al. (Biologia, 2021)

Icariin, Formononetin and Caffeic Acid Phenethyl Ester Inhibit Feline Calicivirus Replication In Vitro - Zhanding Cui; Qian Wang; Dengliang Li; Shihui Zhao; Qian Zhang; Yuxin Tan; Qianwen Gong; Ting Liu; Jiang Shao; Shuang Zhang; Hailong Huang; Junzheng Wang; et al. (Archives of Virology, 2021)

Soft Liver Phantom with a Hollow Biliary System - Xiangzhou Tan; Dandan Li; Moonkwang Jeong; Tingting Yu; Zhichao Ma; Saif Afat; Karl-Enrst Grund; Tian Qiu (Annals of Biomedical Engineering, 2021)
Hepatobiliary interventions are regarded as difficult minimally-invasive procedures that require experience and skills of physicians. To facilitate the surgical training, we develop a soft, high-fidelity and durable liver phantom with detailed morphology. The phantom is anatomically accurate and feasible for the multi-modality medical imaging, including computer tomography (CT), ultrasound, and endoscopy. The CT results show that the phantom resembles the detailed anatomy of real livers including the biliary ducts, with a spatial root mean square error (RMSE) of 1.7 ± 0.7 mm and 0.9 ± 0.2 mm for the biliary duct and the liver outer shape, respectively. The sonographic signals and the endoscopic appearance highly mimic those of the real organ. An electric sensing system was developed for the real-time quantitative tracking of the transhepatic puncturing needle. The fabrication method herein is accurate and reproducible, and the needle tracking system offers a robust and general approach to evaluate the centesis outcome.

Ras subfamily GTPases regulate development, aflatoxin biosynthesis and pathogenicity in the fungus Aspergillus flavus - Zhuo Zhu; Gengli Ma; Mingkun Yang; Can Tan; Guang Yang; Sen Wang; Na Li; Feng Ge; Shihua Wang (Environmental Microbiology, 2021)
Summary Ras subfamily proteins are molecular switches in signal transduction pathways of many eukaryotes that regulate a variety of cellular processes. Here, the Ras subfamily, encoded by six genes, was identified in Aspergillus flavus : rasA , rasB , rasC , rab‐33 , rheb and rsr1 . The rsr1 deletion mutant (∆ rsr1 ), rheb deletion mutant (∆ rheb ) and double deletion mutant (∆ rheb/rsr1 ) displayed significantly decreased growth and sporulation. Sclerotia formation was significantly decreased for ∆ rheb or ∆ rheb/rsr1 but increased for ∆ rsr1 . Aflatoxin production was significantly increased in ∆ rheb but decreased in ∆ rsr1 and ∆ rheb/rsr1 . We found that rsr1 and rheb are crucial for the pathogenicity of A . flavus . Quantitative proteomics identified 520 differentially expressed proteins (DEPs) for the ∆ rsr1 mutant and 133 DEPs for the ∆ rheb mutant. These DEPs were annotated in multiple biological processes and KEGG pathways in A . flavus . Importantly, we identified the cytokinesis protein SepA in the protein–protein interaction network of rsr1 , and deletion mutants showed that SepA has pleiotropic effects on growth and AF biosynthesis, which may depend on Rsr1 for regulation in A . flavus . Our results indicated that these Ras subfamily proteins exhibited functional redundancy with each other but there were also differences in A . flavus .

Modulation of the 5-HT 3 A receptor current by desacylbaldrinal - Li-Xia Wang; Hu-Lan Chen; Hong-Ling Yan; Fei Tang; Hai Zhang; Hong-Xiang Li; Qiang Ye; Cheng Peng; Yu-Zhu Tan (Natural Product Research, 2021)

Optimization of Hemoglobin Chitosan Glycosylation Conditions and Structural Characteristics and Functions of Glycosylated Hemoglobin after an In vitro Digestion - Junqi Zhan; Gaoshang Li; Beibei Tan (Journal of Aquatic Food Product Technology, 2021)

Distribution and Activity of Ammonia-Oxidizers on the Size-Fractionated Particles in the Pearl River Estuary - Li Ma; Shangjin Tan; Hongbin Liu; Shuh-Ji Kao; Minhan Dai; Jin-Yu Terence Yang (Frontiers in Marine Science, 2021)
To distinguish between the distribution and activity of ammonia-oxidizing bacteria (AOB) and ammonia-oxidizing archaea (AOA) in the Pearl River estuary (PRE), we investigated the DNA- and cDNA-based β-proteobacterial and archaeal amo A genes on three size-fractionated particles of >3.0 μm, 0.45–3.0 μm, and 0.22–0.45 μm. Results showed that AOB were more abundant in the freshwater with high concentrations of ammonium (NH 4 + ) and low dissolved oxygen, whereas AOA were dominant in the NH 4 + -depleted seawater and sensitive to temperature. Obvious shifts in ammonia-oxidizing communities were found along the salinity gradient in the PRE. AOB clearly presented a particle-associated nature, as evidenced by higher relative abundance of amo A genes attached to the large particles (>3.0 μm) and their transcripts exclusively detected on this fraction. Moreover, higher transcriptional activity (indicated by the cDNA/DNA ratio) of AOB on the large particles, suggesting AOB were actively involved in ammonia oxidation despite their lower abundance in the mid- and lower estuarine regions. In contrast, AOA exhibited higher transcriptional activity on the 0.45–3.0 μm and 0.22–0.45 μm particles, implying the free-living strategy of these microbes. Together, these findings from field observations provide useful information on the ecological strategies of ammonia-oxidizing communities in response to different environmental conditions.

New Detecting Method on the Connecting Fractured Zone Above the Coal Face and a Case Study - Xuesheng Liu; Deyuan Fan; Yunliang Tan; Jianguo Ning; Shilin Song; Honglei Wang; Xuebin Li (Rock Mechanics and Rock Engineering, 2021)

Nitrogen and α-Ketoglutaric Acid Application Modulate Grain Yield, Aroma, Nutrient Uptake and Physiological Attributes in Fragrant Rice - Xiaomeng Fu; Runfei Gui; Wu Li; Zifeng Gao; Umair Ashraf; Jiangtao Tan; Qiuyi Ye; Jiale Chen; Huijia Xie; Zhaowen Mo (Journal of Plant Growth Regulation, 2021)

First report of tomato spotted wilt orthotospovirus infection of tamarillo in China - Peng He; Fucheng Luo; Jie Yang; Pingxiu Lan; Fan Li; Guanlin Tan (Journal of Plant Pathology, 2021)

Effects of different types of land-use on taxonomic and functional diversity of benthic macroinvertebrates in a subtropical river network - Zhenyuan Liu; Zhengfei Li; Diego M. P. Castro; Xiang Tan; Xiaoming Jiang; Xingliang Meng; Yihao Ge; Zhicai Xie (Environmental Science and Pollution Research, 2021)

The convergence of species composition along the drawdown zone of the Three Gorges Dam Reservoir, China: implications for restoration - Jie Zheng; Muhammad Arif; Songlin Zhang; Zhongxun Yuan; Limiao Zhang; Zhi Dong; Xue Tan; Wokadala Charles; Changxiao Li (Environmental Science and Pollution Research, 2021)

Double-network cross-linked aerogel with rigid and super-elastic conversion: simple formation, unique properties, and strong sorption of organic contaminants - Longfei Liu; Yanli Liu; Miaomiao Tan; Naiju Che; Chengliang Li (Environmental Science and Pollution Research, 2021)

The adsorption properties of functionalization vetiver grass-based activated carbon: the simultaneous adsorption of phosphate and nitrate - Jianmin Li; Xiuying Fang; Min Yang; Wei Tan; Haocheng Zhang; Yanyan Zhang; Guizhen Li; Hongbin Wang (Environmental Science and Pollution Research, 2021)

Temperature and Moisture Modulate the Contribution of Soil Fauna to Litter Decomposition via Different Pathways - Bo Tan; Rui Yin; Jian Zhang; Zhenfeng Xu; Yang Liu; Shuqin He; Li Zhang; Han Li; Lixia Wang; Sining Liu; Chengming You; Changhui Peng (Ecosystems, 2021)

RETRACTED ARTICLE: Indoleamine 2,3-Dioxygenase 1 (IDO1) Promotes Cardiac Hypertrophy via a PI3K-AKT-mTOR-Dependent Mechanism - Yang Liu; Shuang Li; Zhanqun Gao; Shuangjia Li; Qingyun Tan; Yanmei Li; Dongwei Wang; Qingdong Wang (Cardiovascular Toxicology, 2021)
Indoleamine 2,3-dioxygenase 1 (IDO1) is an enzyme for tryptophan metabolism, involved in immune cell differentiation/maturation and cancer biology. IDO1 is also expressed in cardiomyocytes, but its roles in the cardiovascular system are not fully understood. Here, we reported the functions of IDO1 during cardiac hypertrophy. Quantitative real-time PCR and Western blot experiments demonstrated the upregulation of IDO1 mRNA and protein levels in human and hypertrophic mouse hearts, as well as in angiotensin II (Ang II)-induced hypertrophic rat cardiomyocytes. IDO1 activity and metabolite product kynurenine were upregulated in rodent hypertrophic hearts and cardiomyocytes. Inhibition of IDO1 activity with PF-06840003 reduced Ang II-induced cardiac hypertrophy and rescued cardiac function in mice. siRNA-mediated knockdown of Ido1 repressed Ang II-induced growth in cardiomyocyte size and overexpression of hypertrophy-associated genes atrial natriuretic peptide ( Anp or Nppa ), brain natriuretic peptide ( Bnp or Nppb ), β-myosin heavy chain ( β-Mhc or Myh7 ). By contrast, adenovirus-mediated rat Ido1 overexpression in cardiomyocytes promoted hypertrophic growth induced by Ang II. Mechanism analysis showed that IDO1 overexpression was associated with PI3K-AKT-mTOR signaling to activate the ribosomal protein S6 kinase 1 (S6K1), which promoted protein synthesis in Ang II-induced hypertrophy of rat cardiomyocytes. Finally, we provided evidence that inhibition of PI3K with pictilisib, AKT with perifosine, or mTOR with rapamycin, blocked the effects of IDO1 on protein synthesis and cardiomyocyte hypertrophy in Ang II-treated cells. Collectively, our findings identify that IDO1 promotes cardiomyocyte hypertrophy partially via PI3K-AKT-mTOR-S6K1 signaling.

Associations of Dietary Exposure to Organochlorine Pesticides from Plant-Origin Foods with Lipid Metabolism and Inflammation in Women: A Multiple Follow-up Study in North China - Xuepeng Wang; Miaomiao Gao; Yixi Tan; Qi Li; Junxi Chen; Changxin Lan; Bahabieke Jiangtulu; Bin Wang; Guofeng Shen; Yanxin Yu; Zhiwen Li (Bulletin of Environmental Contamination and Toxicology, 2021)

Effect of oxygen on damage mechanism and mechanical properties of sandstone at high temperature - Tubing Yin; Dengdeng Zhuang; Qiang Li; Xiaosong Tan; You Wu (Bulletin of Engineering Geology and the Environment, 2021)

A multi-domain prognostic model of disorder of consciousness using resting-state fMRI and laboratory parameters - Yamei Yu; Fanxia Meng; Li Zhang; Xiaoyan Liu; Yuehao Wu; Sicong Chen; Xufei Tan; Xiaoxia Li; Sheng Kuang; Yu Sun; Benyan Luo (Brain Imaging and Behavior, 2021)

First-principles calculations of thermodynamic properties of Ni sulfides in the upper mantle - Huiquan Tian; Shanqi Liu; Qiuyuan Zhang; Yang Zhao; Shucheng Tan; Yongbing Li (Physics and Chemistry of Minerals, 2021)

Hydrogeochemical and isotopic characteristics of spring water in the Yarlung Zangbo River Basin, Qinghai-Tibet Plateau, Southwest China - Ying-zhi Li; Zong-jun Gao; Jiu-tan Liu; Min Wang; Cong Han (Journal of Mountain Science, 2021)

Environmental Drivers of Temporal and Spatial Fluctuations of Mesozooplankton Community in Daya Bay, Northern South China Sea - Kaizhi Li; Jie Ma; Liangmin Huang; Yehui Tan; Xingyu Song (Journal of Ocean University of China, 2021)

Acutely Rising Temperature Reduces Photosynthetic Capacity of Phytoplankton Assemblages in Tropical Oceans: A Large-Scale Investigation - Guangming Mai; Jihua Liu; Xiaomin Xia; Xinyue Pang; Binkai Li; Linghui Yu; Yehui Tan; Xingyu Song; Gang Li (Frontiers in Marine Science, 2021)
Climate changes interacting with human activities are raising the temperature in global oceans. To explore physiological responses of in situ phytoplankton assemblages to increasing temperatures, we conducted a shipboard experiment in tropical regions of the eastern Indian Ocean, Java Sea, and southern South China Sea. Throughout the surveyed areas, phytoplankton biomass (Chl a ) ranged from 0.09 to 0.86 μg L −1 (median, 0.22 μg L −1 ) in the surface and from 0.30 to 0.99 μg L −1 (median, 0.50 μg L −1 ) in maximal chlorophyll layer (DCM), respectively. Picophytoplankton that occupied 27–89% (79%) and 83–92% (88%) of total Chl a in the surface and DCM layers, ranged from 0.32 × 10 4 to 23.10 × 10 4 cells mL −1 (3.69 × 10 4 cells mL −1 ) and from 7.44 × 10 4 to 25.70 × 10 4 cells mL −1 (12.60 × 10 4 cells mL −1 ), respectively. Synechococcus took up 30–97% (78%) of pico-cells compositions in the surface layer, while, in the DCM layer, Prochlorococcus took up 42–98% (91%). Moreover, the maximal photochemical quantum yield (F V /F M ) of photosystem II (PS II) and the rapid light curve (RLC)-derived light utilization efficiency ( α ) were lower in the surface layer than that in the DCM layer, but the saturation irradiance (E K ) was higher. In particular, we found that acutely rising temperature decreased the F V /F M and α in both the surface and the DCM layers but increased the absorption cross-section (σ PSII ) of PSII photochemistry. Our results clearly indicate that the presently rising temperature adversely affects the photophysiology of natural phytoplankton assemblages in tropical oceans.

Investigation of culturable human gut mycobiota from the segamat community in Johor, Malaysia - Marie Andrea Laetitia Huët; Li Wen Wong; Calvin Bok Sun Goh; Md Hamed Hussain; Nazmul Hasan Muzahid; Jacky Dwiyanto; Shaun Wen Huey Lee; Qasim Ayub; Daniel Reidpath; Sui Mae Lee; Sadequr Rahman; Joash Ban Lee Tan (World Journal of Microbiology and Biotechnology, 2021)

Improving rice eating and cooking quality by coordinated expression of the major starch synthesis-related genes, SSII and Wx, in endosperm - Lichun Huang; Zhengwen Gu; Zhuanzhuan Chen; Jiawen Yu; Rui Chu; Hongyan Tan; Dongsheng Zhao; Xiaolei Fan; Changquan Zhang; Qianfeng Li; Qiaoquan Liu (Plant Molecular Biology, 2021)

Design, synthesis, and antidepressant/anticonvulsant activities of 3H-benzo[f]chromen chalcone derivatives - Qiu-Wan Tan; Li-Ya He; Zhi-Wen He; Wei-Hua Liu; Shan-Shan Zhang; Lin Lin; Hong-Li Yang; Li-Ping Guan (Medicinal Chemistry Research, 2021)

Strong in vitro and in vivo cytotoxic effects of two platinum(II) complexes with cryptolepine derivatives - Li-Qin Qin; Zu-Zhuang Wei; Lin Yang; Qi-Pin Qin; Jia-Jing Zeng; Ming-Xiong Tan; Hong Liang (Medicinal Chemistry Research, 2021)

Effects of Amino Acids and Overexpression of dapA Gene on the Production of ε-Poly-L-lysine by Streptomyces diastatochromogenes Strains - Wenchao Li; Junge Lv; Tianyu Dong; Xinying Li; Xiaona Li; Zhilei Tan; Shiru Jia (Current Microbiology, 2021)

Cloning and characterization of a novel thermostable amidase, Xam, from Xinfangfangia sp. DLY26 - Lijun Xi; Wenfei Tan; Jing Li; Jianbo Qu; Jianguo Liu (Biotechnology Letters, 2021)

Metabolic cold adaptation in the Asiatic toad: intraspecific comparison along an altitudinal gradient - Song Tan; Ping Li; Zhongyi Yao; Gaohui Liu; Bisong Yue; Jinzhong Fu; Jingfeng Chen (Journal of Comparative Physiology B, 2021)

Using the Metabolome to Understand the Mechanisms Linking Chronic Arsenic Exposure to Microglia Activation, and Learning and Memory Impairment - Rui-Yuan Zhang; Jie-Bai Tu; Rui-Tu Ran; Wen-Xuan Zhang; Qiang Tan; Ping Tang; Tao Kuang; Shu-Qun Cheng; Cheng-Zhi Chen; Xue-Jun Jiang; Chang Chen; Ting-Li Han; et al. (Neurotoxicity Research, 2021)

Mapping Domain- and Age-Specific Functional Brain Activity for Children’s Cognitive and Affective Development - Lei Hao; Lei Li; Menglu Chen; Jiahua Xu; Min Jiang; Yanpei Wang; Linhua Jiang; Xu Chen; Jiang Qiu; Shuping Tan; Jia-Hong Gao; Yong He; et al. (Neuroscience Bulletin, 2021)

Photobiomodulation Promotes Neuronal Axon Regeneration After Oxidative Stress and Induces a Change in Polarization from M1 to M2 in Macrophages via Stimulation of CCL2 in Neurons: Relevance to Spinal Cord Injury - Qiao Zheng; Jiawei Zhang; Xiaoshuang Zuo; Jiakai Sun; Zhuowen Liang; Xueyu Hu; Zhe Wang; Kun Li; Jiwei Song; Tan Ding; Xuefeng Shen; Yangguang Ma; et al. (Journal of Molecular Neuroscience, 2021)

L-3-n-Butylphthalide Effectively Improves the Glymphatic Clearance and Reduce Amyloid-β Deposition in Alzheimer’s Transgenic Mice - Bo Zhang; Wei Li; Youguang Zhuo; Hui Xiang; Wenfeng Li; Hongying Liu; Longchang Xie; Qingchun Gao; Sheng Tan (Journal of Molecular Neuroscience, 2021)

Enhanced treatment of shale gas fracturing waste fluid through plant-microbial synergism - Bo Shao; Xu Tan; Ju-Long Li; Mei He; Lei Tian; Wen-Jie Chen; Yan Lin (Environmental Science and Pollution Research, 2021)

Transport of surface-modified multi-walled carbon nanotubes in saturated porous media - Miaomiao Tan; Longfei Liu; Deyun Li; Chengliang Li (Environmental Science and Pollution Research, 2021)

Correlation and the concentrations of Pb, Cd, Hg and As in vegetables and soils of Chongqing, China - Jibao Deng; Wenyi Li; Weihong Xu; Zhangmi He; Xing Tan (Environmental Geochemistry and Health, 2021)

Analytical method for estimating leakage of reservoir basins for pumped storage power stations - Chao Yang; Zhenzhong Shen; Jiacheng Tan; Gehang Li (Bulletin of Engineering Geology and the Environment, 2021)

Molecular Analysis Associated with Early Flowering Mutant in Brassica napus - Jiawang Mao; Yanhua Yang; Ningning Wang; Keming Zhu; Yulong Li; Zheng Wang; Xiaoli Tan (Journal of Plant Biology, 2021)

Contrasting characteristics and origin of Danxia arched rock shelters in Zhejiang, China, and natural arches and bridges on the Colorado Plateau, USA - Yufang Tan; Lihui Li; Beixiu Huang (Journal of Geographical Sciences, 2021)

Molecular surveillance of coxsackievirus A16 in southern China, 2008–2019 - Lina Yi; Hanri Zeng; Huanying Zheng; Jinju Peng; Xue Guo; Leng Liu; Qianling Xiong; Limei Sun; Xiaohua Tan; Jianfeng He; Jing Lu; Hui Li (Archives of Virology, 2021)

Pigmentibacter ruber gen. nov., sp. nov., a novel bacterium of the family Silvanigrellaceae isolated from human blood - Na Peng; Wen Xu; Hai-Min Luo; Peng-Wen Ouyang; Bin Jiang; Zhi-Hua Zhang; You-De Cao; Li-Ming Tan; Ping-Hua Qu; Liang-Yi Xie (Antonie van Leeuwenhoek, 2021)

Effects of prenatal exposure to bisphenols on newborn leucocyte telomere length: a prospective birth cohort study in China - Jun Liang; Yantao Shao; Dongping Huang; Chunxiu Yang; Tao Liu; Xiaoyun Zeng; Chunling Li; Zhenghua Tang; Jennifer Tan Hui Juan; Yanye Song; Shun Liu; Xiaoqiang Qiu (Environmental Science and Pollution Research, 2021)

Design of supercontinuum laser hyperspectral light detection and ranging (LiDAR) (SCLaHS LiDAR) - Guoqing Zhou; Xiang Zhou; Youjian Song; Donghui Xie; Long Wang; Guangjian Yan; Minglie Hu; Bowen Liu; Weidong Shang; Chenghu Gong; Cheng Wang; Huaguo Huang; et al. (International Journal of Remote Sensing, 2021)

Improved Network Reliability Optimization Model with Head Loss for Water Distribution System - Tianwei Mu; Yaqi Li; Ziyi Li; Luyue Wang; Haoqiang Tan; Chengzhi Zheng (Water Resources Management, 2021)

Correction to: Utilization of a Wheat55K SNP array-derived high-density genetic map for high-resolution mapping of quantitative trait loci for important kernel-related traits in common wheat - Tianheng Ren; Tao Fan; Shulin Chen; Chunsheng Li; Yongyan Chen; Xia Ou; Qing Jiang; Zhenglong Ren; Feiquan Tan; Peigao Luo; Chen Chen; Zhi Li (Theoretical and Applied Genetics, 2021)

Correction to: Exploring the Genetic Association of the ABAT Gene with Alzheimer’s Disease - Quanzhen Zheng; Rui Bi; Min Xu; Deng-Feng Zhang; Li-Wen Tan; Ya-Ping Lu; Yong-Gang Yao (Molecular Neurobiology, 2021)

Exploring the Genetic Association of the ABAT Gene with Alzheimer’s Disease - Quanzhen Zheng; Rui Bi; Min Xu; Deng-Feng Zhang; Li-Wen Tan; Ya-Ping Lu; Yong-Gang Yao (Molecular Neurobiology, 2021)

Taxonomic reassessment of Polysiphonia hainanensis (Rhodomelaceae, Rhodophyta) based on molecular and morphological analyses - Huaqiang Tan; Wenhua Liu; Ping Li (Journal of Oceanology and Limnology, 2021)

High leaf area index inhibits net primary production in global temperate forest ecosystems - Wei Zhao; Wenfeng Tan; Shiqing Li (Environmental Science and Pollution Research, 2021)

The Association Between Insular Subdivisions Functional Connectivity and Suicide Attempt in Adolescents and Young Adults with Major Depressive Disorder - Lan Hu; Muni Xiao; Jun Cao; Zhaojun Tan; Mengyao Wang; Li Kuang (Brain Topography, 2021)

Characterization of the structure, vascularity, and stem/progenitor cell populations in porcine Achilles tendon (PAT) - Jianying Zhang; Feng Li; Kelly M. Williamson; Susheng Tan; Devon Scott; Kentaro Onishi; MaCalus V. Hogan; James H.-C. Wang (Cell and Tissue Research, 2021)

The impact of biogenic emissions on ozone formation in the Yangtze River Delta region based on MEGANv3.1 - Yangjun Wang; Xingjian Tan; Ling Huang; Qian Wang; Hongli Li; Hongyan Zhang; Kun Zhang; Ziyi Liu; Dramane Traore; Elly Yaluk; Joshua S. Fu; Li Li (Air Quality, Atmosphere & Health, 2021)

Forward modeling and inversion of the relation model between the gas content of plume and its seismic attribute - Canping Li; Jiachun You; Yanchun Tan; Fengying Chen; Yilin Liu; Zihao Guo; Xinyu Tian (Acta Oceanologica Sinica, 2021)

Impacts of land use change on thermodynamic and dynamic changes of precipitation for the Yangtze River Basin, China - Qian Lin; Jie Chen; Wei Li; Kailin Huang; Xuezhi Tan; Hua Chen (International Journal of Climatology, 2021)
Many studies found that land use change (LUC) had great impacts on regional precipitation, due to thermodynamic and dynamic responses. However, the relative contributions of these two factors to changes in precipitation due to LUC are rarely investigated. This study quantifies the relative contributions of thermodynamic and dynamic to the changes of mean and extreme precipitation due to LUC based on simulations of the Weather Research and Forecasting (WRF) model. The Yangtze River Basin (YRB) is used as a case study, as it has experienced great LUC during the past decades. Four land use scenarios (two factual cases and two hypothetical reforestation scenarios) were used to test the sensitivity of precipitation changes to LUC. Changes in mean and extreme precipitation over the YRB for all seasons are attributed to thermodynamic and dynamic changes using 500‐hPa geopotential height and precipitation data derived from the simulations of WRF. The results show that the factual process of LUC results in a decrease in summer mean daily precipitation and precipitation extremes in most areas of the YRB (except for the middle reaches of the YRB), while the hypothetical reforestation contributes to an increase in summer mean and extreme precipitation, and the impacts of reforestation on increasing precipitation are limited. The thermodynamic change contributes to an increase in seasonal mean daily precipitation, extreme precipitation totals and occurrence frequency of precipitation extremes with contributions ranging from 94 to 102%, which is the main contributor of changes in precipitation due to LUC. The dynamic change only makes a small contribution to the change of precipitation. Because the contributions of thermodynamic can be offset by dynamic changes to changes in precipitation, it could result in minimal changes in precipitation and occurrences of precipitation extremes.

Astronomical Tide and Storm Surge Signals Observed in an Isolated Inland Maar Lake Near the Coast - Mingming Li; Chunyan Li; Lingling Xie; Wei Huang; Quanan Zheng; Keyi Tan; Yingbin Hong (Journal of Marine Science and Engineering, 2021)
Aimed at the explanation of clear tidal signal and storm surge signals in a closed inland lake near the coast (the Huguangyan Lake), this work uses a combined approach with observations and model experiments. Huguangyan Lake is a closed inland freshwater coneless volcanic crater lake near the coast in tropical southern China, less than 5 km from an estuary. It has a diameter of about 1.5 km and relatively deep water of up to 20 m. Bottom pressure was measured from an acoustic Doppler current profiler (ADCP) for 10 days in September 2018 and 10 days in January 2019. The observations encompass the period of Typhoon Mangkhut, which passed the region when it made its landfall. The time series demonstrate clear tidal and subtidal signals. The tidal signal remains even if we exclude the barometric pressure effect. Interestingly, the lake has no surface connection with the ocean. The astronomical tide has an amplitude of about 2 cm. The major tidal signals include the principal solar semidiurnal (S2) and lunisolar (K1) constituents. During the passage of Typhoon Mangkhut, the water level variability inside the lake increased by an order of magnitude (>0.3 m). To examine whether the lake water level change was due to the natural oscillations inside the lake (or seiche), a numerical wind-driven hydrodynamics model was designed using the 3-D Finite Volume Community Ocean Model (FVCOM). The results show that a small first-order seiche can be generated, but only with a time scale of minutes and with a magnitude much smaller than the observed surface elevation changes. This excludes any measurable seiche and the observed surface elevation change inside the lake cannot be wind-driven. Moreover, tides inside the lake are not generated by tidal potential, as the lake is too small for having a locally generated tide. The main result of our study has therefore excluded the local tidal-generating force, wind-driven seiche, and barometric effect, as possible causes of the lake oscillation which has tidal and subtidal signals. The subtidal variation is at least one order of magnitude greater than tides inside the lake and is caused by weather-induced overall coastal ocean water level oscillations transmitted into the lake through groundwater connection. All these lead to the major conclusion that the lake is connected to the coastal ocean through groundwater.

Differential Physiological Responses of Small Thalassiosira pseudonana and Large Thalassiosira punctigera to the Shifted-High Light and Nitrogen - Zhen Qin; Xiaomin Xia; Guangming Mai; Yehui Tan; Gang Li (Journal of Marine Science and Engineering, 2021)
With global warming, the intensity and frequency of extreme episodic weather events such as typhoons are rising in tropical and subtropical regions, disturbing the water column and shifting phytoplankton therein from deep to surface layers, and exposing them to high light as well as nutrients. To explore how phytoplankton respond to such environmental changes, we tracked the growth, cell compositions and physiology of small Thalassiosira pseudonana and large Thalassiosira punctigera from simulated ambient to upward-shifted light and nitrogen (N) conditions. Shifting to high levels of light caused a limited effect on the growth of small T. pseudonana, but reduced that of large T. punctigera by 36%, with supplemental N alleviating the light-caused growth reduction. The upward-shifted light reduced the cellular pigments contents in small T. pseudonana, but not in large T. punctigera. The upward-shifted light reduced the photosynthetic capability (FV/FM) of both species, as well as the light utilization efficiency (α) and maximal relative electron transport rate (rETRmax), but it enhanced their dark reparations. Moreover, the upward-shifted light did not affect the superoxide dismutase (SOD) activity of small T. pseudonana, but it did enhance that of large T. punctigera. In addition, the supplemental N showed a limited effect on cellular pigments and the dark respiration of T. pseudonana, but it reduced that of T. punctigera. Our results showed that the growth responses of Thalassiosira to upward-shifted light and nitrogen vary with species and possibly with cell size, indicating that the field species composition might change after the occurrence of extreme weather events.

Potential agro-thermal resources dynamic for double-season rice cultivation across China under greenhouse gas emission scenarios - Lei Zhang; Sen Li; Fangying Tan; Anhong Guo; Zhiguo Huo (Theoretical and Applied Climatology, 2021)

New insights on the surface hydrological connectivity of water depth thresholds in a flood-pulse-influenced floodplain system (Poyang Lake, China) - Yunliang Li; Qi Zhang; Xinggen Liu; Zhiqiang Tan; Jing Yao (Stochastic Environmental Research and Risk Assessment, 2021)

A Photopolymerized Semi-Interpenetrating Polymer Networks-Based Hydrogel Incorporated with Nanoparticle for Local Chemotherapy of Tumors - Yeying Wang; Qilong Li; Jing-e Zhou; Jingwen Tan; Minghao Li; Nan Xu; Feng Qu; Jian Chen; Ji Li; Jing Wang; Zhiqiang Liang; Lei Yu; et al. (Pharmaceutical Research, 2021)

EEG-Based Anxious States Classification Using Affective BCI-Based Closed Neurofeedback System - Chao Chen; Xuecong Yu; Abdelkader Nasreddine Belkacem; Lin Lu; Penghai Li; Zufeng Zhang; Xiaotian Wang; Wenjun Tan; Qiang Gao; Duk Shin; Changming Wang; Sha Sha; et al. (Journal of Medical and Biological Engineering, 2021)

Regional Changes of Iris Stiffness in the Rabbits Suffered from Chronic High Intraocular Pressure - Tan Li; Xiao Qin; Haixia Zhang; Lin Li; Zhicheng Liu (Journal of Medical and Biological Engineering, 2021)

Symbiotic fungi in nature Finnish peat moss promote vegetative growth in rabbiteye blueberry cuttings - Yu-Chuan Li; Shiang-Jiuun Chen; Kuo-Tan Li (Horticulture, Environment, and Biotechnology, 2021)

Characterization of EST-SSR markers in Curcuma kwangsiensis S. K. Lee & C. F. Liang based on RNA sequencing and its application for phylogenetic relationship analysis and core collection construction - Yuanjun Ye; Yechun Xu; Dongmei Li; Jianjun Tan; Jinmei Liu (Genetic Resources and Crop Evolution, 2021)

The prevalence and risks of major comorbidities among inpatients with pulmonary tuberculosis in China from a gender and age perspective: a large-scale multicenter observational study - Wanli Kang; Jian Du; Song Yang; Jiajia Yu; Hongyan Chen; Jianxiong Liu; Jinshan Ma; Mingwu Li; Jingmin Qin; Wei Shu; Peilan Zong; Yi Zhang; et al. (European Journal of Clinical Microbiology & Infectious Diseases, 2021)

Impact of solar ultraviolet radiation on daily outpatient visits of atopic dermatitis in Shanghai, China - Hui-jing Gu; Li Peng; Wen-cai Jiang; Yi-mei Tan; Guo-jiang Zhou; Hai-dong Kan; Ren-jie Chen; Ying Zou (Environmental Science and Pollution Research, 2021)

Catalyst-free visible-light induced synthesis of nitrogen- and oxygen-containing heterocycles from 1,3-diketones - Lu Chen; Zhenyuan lin; Xuefang Zhang; Leshi Tan; Min Zhang; Yibiao Li (Environmental Chemistry Letters, 2021)

miR-23b Attenuates LPS-Induced Inflammatory Responses in Acute Lung Injury via Inhibition of HDAC2 - Zhi-Feng Luo; Xiang-Hui Jiang; Huan Liu; Li-Yuan He; Xiong Luo; Fu-Chun Chen; Yu-Lin Tan (Biochemical Genetics, 2021)

AKR1C1 Contributes to Cervical Cancer Progression via Regulating TWIST1 Expression - Xing Wei; Zhongheng Wei; Yueyong Li; Zhongqiu Tan; Cheng Lin (Biochemical Genetics, 2021)

miR-491-3p is Downregulated in Retinoblastoma and Inhibit Tumor Cells Growth and Metastasis by Targeting SNN - Yang Hu; Ming Zhao; Li Li; Jie Ding; Yu-Min Gui; Tan-Wei Wei (Biochemical Genetics, 2021)
Retinoblastoma (Rb) is the most common pediatric malignant tumor of the eyes. Previous studies demonstrated that miR-491-3p is downregulated in various cancers. However, its function in Rb remains unknown. A total of 15 pairs of primary Rb tissues and adjacent noncancerous tissues were collected. Quantitative real-time PCR (qRT-PCR) was used to investigate the expression profiles of miR-491-3p. qRT-PCR, western blotting and in situ immunocytochemistry were performed to investigate the expression profiles of epithelial–mesenchymal transition-related proteins (E-cadherin, Vimentin and N-cadherin) in Rb tissues and Rb cell lines as well as cell morphology. Cell proliferation was estimated by MTS and colony formation assays. Apoptosis was determined by FACS, cell migration and invasion were analyzed using transwell chambers. MiR-491-3p’s target genes were predicted using target gene prediction databases. The interplay between miR-491-3p and SNN was evaluated through dual luciferase reporter gene assay. MiR-491-3p was significantly downregulated in mixed collection of 15 pairs of Rb tissues and Rb cell lines. Overexpression of miR-491-3p enhanced apoptosis, and significantly suppressed proliferation, migration and invasion of Rb cells. In contrast, the present of miR-491-3p inhibitor showed reversed results which apoptosis decreased, while cell proliferation of ARPE-19 cells increased. In addition, miR-491-3p increased the expression of E-cadherin, and dramatically decreased the expression of Vimentin and N-cadherin in Rb tissues and Rb cell lines, noticeable changes in morphology, too, as cells became less cohesive and more adhering. We found out that SNN was the pairing target of miR-491-3p and result showed that miR-491-3p and SNN interacted with each other. We also found out that the effects of miR-491-3p were in Rb cells were almost entirely canceled out at the overexpression of SNN. Our findings collectively suggest that miR-491-3p is an important tumor suppressor in Rb, which inhibits tumor growth and metastasis in Rb. These implicate it may be explored as a new therapeutic target in Rb.

Air permeability of biochar-amended clay cover - Ming-Yu Li; Wen-Jing Sun; Ye-Jiao Wang; De-An Sun; Yun-Zhi Tan (Arabian Journal of Geosciences, 2021)

Subcutaneous Delivery of Albumin: Impact of Thermosensitive Hydrogels - Nidhi Patel; Nan Ji; Yingzhe Wang; Xingcong Li; Nigel Langley; Chalet Tan (AAPS PharmSciTech, 2021)

New cytotoxic biflavones from Selaginella doederleinii - Li-Fei Liu; Hui-Hui Sun; Jian-Bing Tan; Qi Huang; Fei Cheng; Kang-Ping Xu; Zhen-Xing Zou; Gui-Shan Tan (Natural Product Research, 2021)

A safety assessment for the Guanlei Port – Qingsheng Port water corridors on the Lancang – Mekong River - Zhifang Zhao; Wenchun Wu; Jisheng Xia; Xuehao Fu; Yixun Fu; Shucheng Tan; Yimin Li (International Journal of Remote Sensing, 2021)

Amplification of Winter Sea surface temperature response over East China Seas to global warming acceleration and slowdown - Hongjian Tan; Rongshuo Cai; Xiuhua Yan; Cuihua Li (International Journal of Climatology, 2021)
The global mean surface temperature does not increase monotonously over the past decades, with accelerated warming from the late 1970s to 1998 and followed by the warming slowdown during 1998–2013 (the so‐called warming hiatus). This study assessed and compared the temporal evolutions of sea surface temperature (SST) trends in the East China Seas (ECS, including Bohai, Yellow and East China Sea) and other key ocean regions. The results revealed an amplified response of ECS SST to both global warming acceleration and hiatus. This amplification was manifested as remarkably enhanced winter warming rates in the ECS of over 1.1 and 0.8°C⋅decade –1 for the 1980–1989 and 1990–1999, respectively, and as an obvious cooling trend of nearly −0.5°C⋅decade ‑1 during 1998–2013. The enhanced response can be explained well by the combined effects of the Kuroshio Current (KC) and East Asian Winter Monsoon (EAWM). The weakened EAWM during the 1980s, accompanied by lower wind speeds and higher air temperatures, impeded the releases of latent and sensible heat fluxes from the ocean to the atmosphere, resulting in rapid ECS warming. During 1998–2013, the strengthened EAWM led to the enhanced cooling trend in the ECS. In addition, the volume transport of the KC east of Taiwan strengthened (weakened) during the 1990s (2000s), which might also have contributed to the enhanced warming (cooling) in the ECS. Our research suggests their sensitivity makes the ECS potentially vulnerable to the effects of global climate change, which has important implications regarding regional impact assessments.

Utilization of a Wheat55K SNP array-derived high-density genetic map for high-resolution mapping of quantitative trait loci for important kernel-related traits in common wheat - Tianheng Ren; Tao Fan; Shulin Chen; Chunsheng Li; Yongyan Chen; Xia Ou; Qing Jiang; Zhenglong Ren; Feiquan Tan; Peigao Luo; Chen Chen; Zhi Li (Theoretical and Applied Genetics, 2021)

Effects of simulated drought stress on carotenoid contents and expression of related genes in carrot taproots - Rong-Rong Zhang; Ya-Hui Wang; Tong Li; Guo-Fei Tan; Jian-Ping Tao; Xiao-Jun Su; Zhi-Sheng Xu; Yong-Sheng Tian; Ai-Sheng Xiong (Protoplasma, 2021)

Prevalence of Depression or Depressive Symptoms in Patients with Narcolepsy: a Systematic Review and Meta-Analysis - Xiao Li; Larry D. Sanford; Qiang Zong; Ye Zhang; Lu Tan; Taomei Li; Rong Ren; Junying Zhou; Fang Han; Xiangdong Tang (Neuropsychology Review, 2021)

Novel Peptide Inhibitors of β-Catenin Effectively Suppress the Tumorigenesis of Colorectal Cancer - Honglin Liu; Xingyun Liu; Yuexi Li; Xia Zhou; Xiutao Tan; Bo Niu; Niuliang Cheng; Hailin Liu (International Journal of Peptide Research and Therapeutics, 2021)

SH2 domain-containing protein tyrosine phosphatase-2 (SHP-2) prevents cardiac remodeling after myocardial infarction through ERK/SMAD signaling pathway - Yong-Gang Lu; He Tan; Qian Ma; Xin-Xin Li; Jia Cui; Xue Zhang; Xue-Lei Liang; Yan-Qing Tie (Human Cell, 2021)

Antimonate removal by diatomite modified with Fe-Mn oxides: application and mechanism study - Qiu-Yi Dong; Yu-Chun Fang; Bin Tan; Aura Ontiveros-Valencia; Ang Li; He-Ping Zhao (Environmental Science and Pollution Research, 2021)

Effects of Dietary Zinc-Methionine Supplementation During Pregnancy on the Whole-Genome Methylation and Related Gene Expression in the Liver and Spleen of Growing Goats: a Short Communication - Qiushuang Li; Qiongxian Yan; Chuanshe Zhou; Shaoxun Tang; Xuefeng Han; Zhiliang Tan (Biological Trace Element Research, 2021)

Polyamine oxidase (PAO)–mediated polyamine catabolism plays potential roles in peach (Prunus persica L.) fruit development and ripening - Wei Wang; Xianbo Zheng; Shihao Liu; Bin Tan; Jun Cheng; Xia Ye; Jidong Li; Jiancan Feng (Tree Genetics & Genomes, 2021)

Comparison of Long-Term Outcomes of Endoscopic and Minimally Invasive Catheter Evacuation for the Treatment of Spontaneous Cerebellar Hemorrhage - Leiyang Li; Haixiao Liu; Jianing Luo; Zhijun Tan; Junmei Gao; Ping Wang; Wenting Jing; Ruixi Fan; Xiaoyang Zhang; Hao Guo; Hao Bai; Wenxing Cui; et al. (Translational Stroke Research, 2021)
Recently, minimally invasive techniques, including endoscopic evacuation and minimally invasive catheter (MIC) evacuation, have been used for the treatment of patients with spontaneous cerebellar hemorrhage (SCH). However, credible evidence is still needed to validate the effects of these techniques. To explore the long-term outcomes of both surgical techniques in the treatment of SCH. Fifty-two patients with SCH who received endoscopic evacuation or MIC evacuation were retrospectively reviewed. Six-month mortality and the modified Rankin Scale (mRS) score were the primary and secondary outcomes, respectively. A multivariate logistic regression model was used to assess the effects of the different surgical techniques on patient outcomes. In the present study, the mortality rate for the entire cohort was 34.6%. Univariate analysis showed that the surgical technique and preoperative Glasgow Coma Scale (GCS) score affected 6-month mortality. However, no variables were found to be correlated with 6-month mRS scores. Further multivariate analysis demonstrated that 6-month mortality in the endoscopic evacuation group was significantly lower than that in the MIC evacuation group (OR = 4.346, 95% CI 1.056 to 17.886). The 6-month mortality rate in the preoperative GCS 9–14 group was significantly lower than that in the GCS 3–8 group (OR = 7.328, 95% CI 1.723 to 31.170). Compared with MIC evacuation, endoscopic evacuation significantly decreased 6-month mortality in SCH patients. These preliminary results warrant further large, prospective, randomized studies.

A chromosome-level genome assembly of the wild rice Oryza rufipogon facilitates tracing the origins of Asian cultivated rice - Xianrong Xie; Huilong Du; Huiwu Tang; Jianian Tang; Xiyu Tan; Weizhi Liu; Tie Li; Zhansheng Lin; Chengzhi Liang; Yao-Guang Liu (Science China Life Sciences, 2021)

Down-regulation of MANNANASE7 gene in Brassica napus L. enhances silique dehiscence-resistance - Yu-Long Li; Yan-Kun Yu; Ke-Ming Zhu; Li-Na Ding; Zheng Wang; Yan-Hua Yang; Jun Cao; Li-Zhang Xu; Yao-Ming Li; Xiao-Li Tan (Plant Cell Reports, 2021)

Application of the borderline-SMOTE method in susceptibility assessments of debris flows in Pinggu District, Beijing, China - Yongchao Li; Jianping Chen; Chun Tan; Yang Li; Feifan Gu; Yiwei Zhang; Qaiser Mehmood (Natural Hazards, 2021)

First report of natural infection of tomato by pepper mild mottle virus in China - Wen Peng Zhou; Yue Yue Li; Fan Li; Guan Lin Tan (Journal of Plant Pathology, 2021)

IL-21 enhances STAT3/Blimp-1 signaling pathway in B cells and contributes to plasma cell differentiation in newly diagnosed patients with myasthenia gravis - Yanan Xu; Xiaoyu Huang; Fengzhan Li; Tan Liu; Tingting Yang; Fei Chen; Jie Zhu; Meng Pan; Yong Zhang; Yuzhong Wang; Linlin Fu; Chenghua Xiao; et al. (Immunologic Research, 2021)

Study on Breakdown Pressure in Hydraulic Fracturing Process of Hard Rock Based on Numerical Simulation - Wen Li; Yuming Liu; Xin Yao; Jinwang Chu; Xiaowei Chen; Zhuoying Tan (Geotechnical and Geological Engineering, 2021)

The contrasting effects of thermodynamic and dynamic processes on East Asian summer monsoon precipitation during the Last Glacial Maximum: a data-model comparison - Yong Sun; Haibin Wu; Masa Kageyama; Gilles Ramstein; Laurent Z. X. Li; Ning Tan; Yating Lin; Bo Liu; Weipeng Zheng; Wenchao Zhang; Liwei Zou; Tianjun Zhou (Climate Dynamics, 2021)
The Last Glacial Maximum (LGM; 21 ka BP) was the most recent glacial period when the global ice sheet volume was at a maximum. Therefore, the LGM can be used to investigate atmospheric dynamics under a climate that differed significantly from the present. This study quantitatively compares pollen records of boreal summer (June–July–August) precipitation with the PMIP3 LGM simulations. The data-model comparison shows an overall agreement on a drier than pre-industrial East Asian summer monsoon (EASM) climate. Nevertheless, 17 out of 55 records show a regional precipitation increase that is also simulated over the additional land mass area due to sea level drop. The thermodynamic and dynamic responses are analyzed to explain a drier LGM EASM as a combination of these two antagonistic mechanisms. Relatively low atmospheric moisture content was the main thermodynamic control on the lower LGM (relative to pre-industrial levels) EASM precipitation amounts in both the reconstructions and the models. In contrast, two dynamic processes in relation to stationary eddy activity act to increase EASM precipitation regionally in records and simulations, respectively. Precipitation increase in records is explained by dynamic enhancement of the horizontal moisture transport, while dynamic enhancement of the vertical moisture transport leads to simulated precipitation increase over the specific region where landmass was exposed during LGM along continental coastlines of China due to significant drop in sea level (relative to pre-industrial levels). Overall, the opposing effects of thermodynamic and dynamic processes on precipitation during the LGM provide a means to reconcile the spatial heterogeneity of recorded precipitation changes in sign, although data-model comparison suggests that the simulated dynamic wetting mechanism is too weak relative to the thermodynamic drying mechanism over data-model disagreement regions.

Insights into the Role of Magnesium Ions in Affecting Osteogenic Differentiation of Mesenchymal Stem Cells - Tiantian Qi; Jian Weng; Fei Yu; Weifei Zhang; Guoqing Li; Haotian Qin; Zhen Tan; Hui Zeng (Biological Trace Element Research, 2021)

New developments in anti-biofilm intervention towards effective management of orthopedic device related infections (ODRI’s) - Ping Li; Zhenwu Gao; Zhenwei Tan; Jun Xiao; Li Wei; Yirui Chen (Biofouling, 2021)

Single-cell transcriptomic analysis reveals dynamic alternative splicing and gene regulatory networks among pancreatic islets - Yunjin Li; Jiwei Chen; Qiyue Xu; Zebei Han; Fei Tan; Tieliu Shi; Geng Chen (Science China Life Sciences, 2021)

A comprehensive integrated transcriptome and metabolome analyses to reveal key genes and essential metabolic pathways involved in CMS in kenaf - Meiqiong Tang; Zengqiang Li; Dengjie Luo; Fan Wei; Muhammad Haneef Kashif; Hai Lu; Yali Hu; Jiao Yue; Zhen Huang; Wenye Tan; Ru Li; Peng Chen (Plant Cell Reports, 2021)

Distinct Effects of Social Stress on Working Memory in Obsessive-Compulsive Disorder - Qianqian Li; Jun Yan; Jinmin Liao; Xiao Zhang; Lijun Liu; Xiaoyu Fu; Hao Yang Tan; Dai Zhang; Hao Yan (Neuroscience Bulletin, 2021)
Stress might exaggerate the compulsion and impair the working memory of patients with obsessive-compulsive disorder (OCD). This study evaluated the effect of stress on the cognitive neural processing of working memory in OCD and its clinical significance using a “number calculation working memory” task. Thirty-eight patients and 55 gender- and education-matched healthy controls were examined. Stress impaired the performance of the manipulation task in patients. Healthy controls showed less engagement of the medial prefrontal cortex and striatum during the task under stress versus less stress, which was absent in the patients with OCD. The diagnosis × stress interaction effect was significant in the right fusiform, supplementary motor area, precentral cortex and caudate. The failure of suppression of the medial prefrontal cortex and striatum and stress-related hyperactivation in the right fusiform, supplementary motor area, precentral cortex, and caudate might be an OCD-related psychopathological and neural response to stress.

A novel displacement prediction method using gated recurrent unit model with time series analysis in the Erdaohe landslide - Yong-gang Zhang; Jun Tang; Zheng-ying He; Junkun Tan; Chao Li (Natural Hazards, 2021)

RAB7L1 Participates in Secondary Brain Injury Induced by Experimental Intracerebral Hemorrhage in Rats - Xiaoxing Tan; Yuchong Wei; Jie Cao; Degang Wu; Niansheng Lai; Ruming Deng; Haiying Li; Haitao Shen; Ya Peng; Xiang Li; Gang Chen (Journal of Molecular Neuroscience, 2021)

Arsenic exposure increased expression of HOTAIR and LincRNA-p21 in vivo and vitro - Jingwen Tan; Mingjun Sun; Quan Luo; Huiwen Sun; Mengjie Wang; Chenglan Jiang; Shuting Li; Yuefeng He (Environmental Science and Pollution Research, 2021)

Inorganic arsenic influences cell apoptosis by regulating the expression of MEG3 gene - Mengjie Wang; Jingwen Tan; Chenglan Jiang; Shuting Li; Xinan Wu; Guanghui Ni; Yuefeng He (Environmental Geochemistry and Health, 2021)

Effects of Litter Quality Diminish and Effects of Vegetation Type Develop During Litter Decomposition of Two Shrub Species in an Alpine Treeline Ecotone - Haifeng Zheng; Yamei Chen; Yang Liu; Petr Heděnec; Yan Peng; Zhenfeng Xu; Bo Tan; Li Zhang; Li Guo; Lifeng Wang; Lars Vesterdal (Ecosystems, 2021)

The two leading modes of winter clear-sky days over China and their formation mechanisms - Huiping Yan; Xiao Pan; Zhiwei Zhu; Rui Lu; Linfei Li; Hui Tan (Climate Dynamics, 2021)

Progress and prospects of applied research on physical geography and the living environment in China over the past 70 years (1949–2019) - Fahu Chen; Shaohong Wu; Peng Cui; Yunlong Cai; Yili Zhang; Yunhe Yin; Guobin Liu; Zhu Ouyang; Wei Ma; Linsheng Yang; Duo Wu; Jiaqiang Lei; et al. (Journal of Geographical Sciences, 2021)

Allotransplantation of adult spinal cord tissues after complete transected spinal cord injury: Long-term survival and functional recovery in canines - He Shen; Shuyu Wu; Xi Chen; Bai Xu; Dezun Ma; Yannan Zhao; Yan Zhuang; Bing Chen; Xianglin Hou; Jiayin Li; Yudong Cao; Xianyong Fu; et al. (Science China Life Sciences, 2020)

Alteration of Streptococcus salivarius in Buccal Mucosa of Oral Lichen Planus and Controlled Clinical Trial in OLP Treatment - Yuting Li; Fangyang Shao; Saiwei Zheng; Zhengwu Tan; Yuan He (Probiotics and Antimicrobial Proteins, 2020)

Waveform Characteristics of Earthquakes Induced by Hydraulic Fracturing and Mining Activities: Comparison with Those of Natural Earthquakes - Nan Li; Baolin Li; Dong Chen; Enyuan Wang; Yuyang Tan; Jiawei Qian; Haishan Jia (Natural Resources Research, 2020)

Grafting Alleviates Cadmium Toxicity and Reduces Its Absorption by Tomato - Yongdong Xie; Huaqiang Tan; Guochao Sun; Huanxiu Li; Dong Liang; Hui Xia; Xun Wang; Ming’an Liao; Honghong Deng; Jin Wang; Yi Tang (Journal of Soil Science and Plant Nutrition, 2020)

The reaction of wastewater treatment and power generation of single chamber microbial fuel cell against substrate concentration and anode distributions - Sing-Mei Tan; Soon-An Ong; Li-Ngee Ho; Yee-Shian Wong; Wei-Eng Thung; Tean-Peng Teoh (Journal of Environmental Health Science and Engineering, 2020)

Association of in-hospital intensive statins dosage and death in arteriosclerotic cardiovascular disease with percutaneous coronary intervention: insights of multicentre cohort from China - Peng-yuan Chen; Yuan-hui Liu; Chong-yang Duan; Hua-lin Fan; Li-huan Zeng; Wei Guo; Lei Jiang; Xue-biao Wei; Wen-fei He; Sha Tao; Zhi-qiang Guo; Ji-yan Chen; et al. (European Journal of Clinical Pharmacology, 2020)

Psychological symptoms in Chinese nurses may be associated with predisposition to chronic disease: a cross-sectional study of suboptimal health status - Jinxiu Zhu; Wenjuan Ying; Li Zhang; Gangyi Peng; Weiju Chen; Enoch Odame Anto; Xueqing Wang; Nan Lu; Shanshan Gao; Guihai Wu; Jingyi Yan; Jianfeng Ye; et al. (EPMA Journal, 2020)
Background Suboptimal health status (SHS) is a reversible state between ideal health and illness and it can be effectively reversed by risk prediction, disease prevention, and personalized medicine under the global background of predictive, preventive, and personalized medicine (PPPM) concepts. More and more Chinese nurses have been troubled by psychological symptoms (PS). The correlation between PS and SHS is unclear in nurses. The purpose of current study is to investigate the prevalence of SHS and PS in Chinese nurses and the relationship between SHS and PS along with predisposing factors as well as to discuss the feasibility of improving health status and preventing diseases according to PPPM concepts in Chinese nurses. Methods A cross-sectional study was conducted with the cluster sampling method among 9793 registered nurses in Foshan city, China. SHS was evaluated with the Suboptimal Health Status Questionnaire-25 (SHSQ-25). Meanwhile, the PS of depression and anxiety were evaluated with Self-Rating Depression Scale (SDS) and Self-Rating Anxiety Scale (SAS) self-assessment questionnaires. The relationship between PS and SHS in Chinese nurses was subsequently analyzed. Results Among the 9793 participants, 6107 nurses were included in the final analysis. The prevalence of SHS in the participants was 74.21% (4532/6107) while the symptoms of depression and anxiety were 47.62% (2908/6107) and 24.59% (1502/6107) respectively. The prevalence of SHS in the participants with depression and anxiety was significantly higher than those without the symptoms of depression (83.3% vs 16.7%, P < 0.001) and anxiety (94.2% vs 5.8%, P < 0.0001). The ratio of exercise habit was significantly lower than that of non-exercise habit (68.8% vs 78.4%, P < 0.001) in SHS group. Conclusions There is a high prevalence of SHS and PS in Chinese nurses. PS in Chinese nurses are associated with SHS. Physical exercise is a protective factor for SHS and PS so that the exercise should be strongly recommended as a valuable preventive measure well in the agreement with PPPM philosophy. Along with SDS and SAS, SHSQ-25 should also be highly recommended and applied as a novel predictive/preventive tool for the health measures from the perspectives of PPPM in view of susceptible population and individual screening, the predisposition to chronic disease preventing, personalization of intervention, and the ideal health state restoring.

First reported case of Gilbertella persicaria in human stool: outcome of a community study from Segamat, Johor, Malaysia - Marie Andrea Laetitia Huët; Li Wen Wong; Calvin Bok Sun Goh; Kuan Shion Ong; Jacky Dwiyanto; Daniel Reidpath; Sui Mae Lee; Sadequr Rahman; Joash Ban Lee Tan (Brazilian Journal of Microbiology, 2020)

Quantifying the Cloud Water Resource: Methods Based on Observational Diagnosis and Cloud Model Simulation - Miao Cai; Yuquan Zhou; Jianzhao Liu; Chao Tan; Yahui Tang; Qianrong Ma; Qi Li; Jietai Mao; Zhijin Hu (Journal of Meteorological Research, 2020)

NC10 bacteria promoted methane oxidation coupled to chlorate reduction - Zi-Yan Li; Xin Li; Bin Tan; Pan-Long Lv; He-Ping Zhao (Biodegradation, 2020)

Interpretation method of nuclear magnetic resonance dual-TW logging in oil-wet tight sandstone reservoirs - Bo Li; Maojin Tan; Haitao Zhang (Applied Geophysics, 2020)

Groundwater resources survey of tongchuan city using the audio magnetotelluric method - Zhi-min Xu; Jing-tian Tang; Guang Li; Hui-Cui Xin; Zhang-jian Xu; Xin-ping Tan; Jin Li (Applied Geophysics, 2020)

Impact of temporal rainfall resolution on daily streamflow simulations in a large-sized river basin - Xiaogang Li; Suzhen Huang; Ruimin He; Guoqing Wang; Mou Leong Tan; Xiaoying Yang; Zheng Zheng (Hydrological Sciences Journal, 2020)

Potential dynamic of irrigation water requirement for rice across Northeast China - Lei Zhang; Fangying Tan; Sen Li; Zhiguo Huo (Theoretical and Applied Climatology, 2020)

Applicability of cosmic-ray neutron sensor for measuring soil moisture at the agricultural-pastoral ecotone in northwest China - Xingyan Tan; Lanhui Zhang; Chansheng He; Yuzuo Zhu; Zhibo Han; Xuliang Li (Science China Earth Sciences, 2020)

Saturated permeability behavior of biochar-amended clay - Wen-Jing Sun; Ming-Yu Li; Wen-Jie Zhang; Yun-Zhi Tan (Journal of Soils and Sediments, 2020)

Induction of SPARC on Oxidative Stress, Inflammatory Phenotype Transformation, and Apoptosis of Human Brain Smooth Muscle Cells Via TGF-β1-NOX4 Pathway - Xianjun Tan; Tao Li; Shaowei Zhu; Weiying Zhong; Feng Li; Yunyan Wang (Journal of Molecular Neuroscience, 2020)