Effects of waterlogging and elevated salinity on the allocation of photosynthetic carbon in estuarine tidal marsh: a mesocosm experiment - Ya-Lei Li; Zhen-Ming Ge; Li-Na Xie; Shi-Hua Li; Li-Shan Tan; Kasper Hancke (Plant and Soil, 2023)

Propofol inhibits glioma progression by regulating circMAPK4/miR-622/HOXA9 axis - Gaopeng Xiao; Liuqiong Yu; Wenmin Tan; Hao Yang; Wensen Li; Rongzhou Xia; Yujin Li (Metabolic Brain Disease, 2023)

Truncation mutations in MYRF underlie primary angle closure glaucoma - Jiamin Ouyang; Wenmin Sun; Huangxuan Shen; Xing Liu; Yingchen Wu; Hongmei Jiang; Xueqing Li; Yingwei Wang; Yi Jiang; Shiqiang Li; Xueshan Xiao; J. Fielding Hejtmancik; et al. (Human Genetics, 2023)

Effect of multiple spatial scale characterization of land use on water quality - Hongran Li; Binjie Zhao; Dezhi Wang; Kerong Zhang; Xiang Tan; Quanfa Zhang (Environmental Science and Pollution Research, 2023)

Characteristics of leachate from refuse transfer stations in rural China - Huiming Xiang; Le Cheng; Weiye Liu; Saier Wang; Yi Zhang; Lianghu Su; Chaoqun Tan; Yuping Li (Environmental Science and Pollution Research, 2023)

Risk assessment and validation of farmland abandonment based on time series change detection - Hang Chen; Yongzhong Tan; Wu Xiao; Suchen Xu; Fei Meng; Tingting He; Xinhui Li; Kechao Wang; Shiqi Wu (Environmental Science and Pollution Research, 2023)

Fumigant toxicity and behavioral inhibition of garlic against red imported fire ants (Solenopsis invicta) - Zixia Song; Yongqing Wang; Chao Li; Yuting Tan; Jian Wu; Zhixiang Zhang (Environmental Science and Pollution Research, 2023)

Correction to: The estimation of influencing factors for carbon emissions based on EKC hypothesis and STIRPAT model: Evidence from top 10 countries - Ellen Thio; MeiXuen Tan; Liang Li; Muhammad Salman; Xingle Long; Huaping Sun; Bangzhu Zhu (Environment, Development and Sustainability, 2023)

Realizing rapid re-convergence in multi-GNSS real-time satellite clock offset estimation with dual-thread integer ambiguity resolution - Wei Xie; Guanwen Huang; Wenju Fu; Mengyuan Li; Shi Du; Yue Tan (GPS Solutions, 2023)

Effects of nitrogen fertilizer on soil microbial residues and their contribution to soil organic carbon and total nitrogen in a rice-wheat system - Quanyi Hu; Tianqi Liu; Huina Ding; Chengfang Li; Wenfeng Tan; Ming Yu; Juan Liu; Cougui Cao (Applied Soil Ecology, 2023)

Dietary supplementation of kaempferol improved the growth, lipid metabolism and flesh quality of juvenile grass carp (Ctenopharyngodon idellus) based on metabolomics - Zhen Xu; Hang Yang; Xiaoqin Li; Xiaoying Xu; Hongxin Tan; Xiangjun Leng (Animal Feed Science and Technology, 2023)

Light addressable potentiometric sensor with well-ordered pyramidal pits-patterned silicon - Jie Tan; Shibin Liu; Jiezhang Luo; Yinghao Chen; Wenbo Zhao; Huijuan Li; Guifang Li; Xueliang Li (Analytica Chimica Acta, 2023)

Recovery of nutrients from aquaculture wastewater: Effects of light quality on the growth, biochemical composition, and nutrient removal of Chlorella sorokiniana - Yuqing He; Jie Lian; Lan Wang; Lu Tan; Fahad Khan; Yanhua Li; Hongxia Wang; Céline Rebours; Danxiang Han; Qiang Hu (Algal Research, 2023)

Solar ring mission: Building a panorama of the Sun and inner-heliosphere - Yuming Wang; Xianyong Bai; Changyong Chen; Linjie Chen; Xin Cheng; Lei Deng; Linhua Deng; Yuanyong Deng; Li Feng; Tingyu Gou; Jingnan Guo; Yang Guo; et al. (Advances in Space Research, 2023)

Genome‐wide SNPs confirm plumage polymorphism and hybridisation within a Cyornis flycatcher species complex - Elize Y. X. Ng; Siqi Li; Dezhi Zhang; Kritika M. Garg; Gang Song; Jonathan Martinez; Le Manh Hung; Vuong Tan Tu; Jérôme Fuchs; Lu Dong; Urban Olsson; Yuan Huang; et al. (Zoologica Scripta, 2023)
Morphology has been a leading taxonomic guiding light to systematists for the last couple of hundred years. However, the genetic and – more recently – genomic revolution have produced numerous demonstrations of erroneous classifications that were based on labile morphological traits. We used thousands of genome‐wide markers to shed light on evolutionary dynamics in a confusing and taxonomically obscure group of Asian Cyornis flycatchers. Using genomic data, we corroborated recent findings based on three mitochrondrial and five nuclear genes that the two taxa hainanus and klossi which were previously treated as separate species ( Cyornis hainanus and Cyornis rubeculoides klossi , respectively) are genomically homogeneous and form a single species, C. hainanus . We also uncovered a novel case of interbreeding between C. hainanus and a non‐sister species, C. glaucicomans , illustrating these flycatchers' ability to hybridise in marginal situations even after substantial times of divergence. Our study illustrates how genome‐wide loci can shed light on complicated taxonomic problems, resulting in a better integration of phenotypic and genotypic data.

The roles of ETS transcription factors in liver fibrosis - Li-Ye Zhang; Yong Tan; Xiao-Jie Luo; Jiang-Feng Wu; Yi-Ran Ni (Human Cell, 2022)

Study on damage evolution and radon exhalation of uranium-bearing granite under high temperature - Yuying Hao; Fuliang Jiang; Biao Tan; Chao Zhang; Mian Zhang; Haoyu Li; Xiaotong Yang; Yixiang Mo; Tao Hu; Shiyan Li; Huiting He (Environmental Science and Pollution Research, 2022)

Diagnostic accuracy of autoverification and guidance system for COVID-19 RT-PCR results - Yingmu Cai; Mengyu Liu; Zhiyuan Wu; Cuihong Tian; Song Qiu; Zhen Li; Feng Xu; Wei Li; Yan Zheng; Aijuan Xu; Longxu Xie; Xuerui Tan (EPMA Journal, 2022)
Background To date, most countries worldwide have declared that the pandemic of COVID-19 is over, while the WHO has not officially ended the COVID-19 pandemic, and China still insists on the personalized dynamic COVID-free policy. Large-scale nucleic acid testing in Chinese communities and the manual interpretation for SARS-CoV-2 nucleic acid detection results pose a huge challenge for labour, quality and turnaround time (TAT) requirements. To solve this specific issue while increase the efficiency and accuracy of interpretation, we created an autoverification and guidance system (AGS) that can automatically interpret and report the COVID-19 reverse transcriptase-polymerase chain reaction (RT-PCR) results relaying on computer-based autoverification procedure and then validated its performance in real-world environments. This would be conductive to transmission risk prediction, COVID-19 prevention and control and timely medical treatment for positive patients in the context of the predictive, preventive and personalized medicine (PPPM). Methods A diagnostic accuracy test was conducted with 380,693 participants from two COVID-19 test sites in China, the Hong Kong Hybribio Medical Laboratory ( n = 266,035) and the mobile medical shelter at a Shanghai airport ( n = 114,658). These participants underwent SARS-CoV-2 RT-PCR from March 28 to April 10, 2022. All RT-PCR results were interpreted by laboratorians and by using AGS simultaneously. Considering the manual interpretation as gold standard, the sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and accuracy were applied to evaluate the diagnostic value of the AGS on the interpretation of RT-PCR results. Results Among the 266,035 samples in Hong Kong, there were 16,356 (6.15%) positive, 231,073 (86.86%) negative, 18,606 (6.99%) indefinite, 231,073 (86.86%, negative) no retest required and 34,962 (13.14%, positive and indefinite) retest required; the 114,658 samples in Shanghai consisted of 76 (0.07%) positive, 109,956 (95.90%) negative, 4626 (4.03%) indefinite, 109,956 (95.90%, negative) no retest required and 4702 (4.10%, positive and indefinite) retest required. Compared to the fashioned manual interpretation, the AGS is a procedure of high accuracy [99.96% (95%CI, 99.95–99.97%) in Hong Kong and 100% (95%CI, 100–100%) in Shanghai] with perfect sensitivity [99.98% (95%CI, 99.97–99.98%) in Hong Kong and 100% (95%CI, 100–100%) in Shanghai], specificity [99.87% (95%CI, 99.82–99.90%) in Hong Kong and 100% (95%CI, 99.92–100%) in Shanghai], PPV [99.98% (95%CI, 99.97–99.99%) in Hong Kong and 100% (95%CI, 99.99–100%) in Shanghai] and NPV [99.85% (95%CI, 99.80–99.88%) in Hong Kong and 100% (95%CI, 99.90–100%) in Shanghai]. The need for manual interpretation of total samples was dramatically reduced from 100% to 13.1% and the interpretation time fell from 53 h to 26 min in Hong Kong; while the manual interpretation of total samples was decreased from 100% to 4.1% and the interpretation time dropped from 20 h to 16 min at Shanghai. Conclusions The AGS is a procedure of high accuracy and significantly relieves both labour and time from the challenge of large-scale screening of SARS-CoV-2 using RT-PCR. It should be recommended as a powerful screening, diagnostic and predictive system for SARS-CoV-2 to contribute timely the ending of the COVID-19 pandemic following the concept of PPPM.

Knockdown of lncRNA-ASLNC12002 alleviates epithelial–mesenchymal transition of type II alveolar epithelial cells in sepsis-induced acute respiratory distress syndrome - Kaixuan Feng; Weifeng Huang; Jiawei Shang; Feng Ping; Qin Tan; Wei Wang; Yingchuan Li; Yongmei Cao (Human Cell, 2022)
Patients with sepsis-induced acute respiratory distress syndrome (ARDS) have higher mortality and poor prognosis than pneumonia-induced ARDS. Pulmonary fibrosis is an irreversible accumulation of connective tissue in the interstitium of the lung and closely associated with the epithelial–mesenchymal transition (EMT) of type II alveolar epithelial cells (AECIIs). Therefore, it is undoubtedly worth studying whether the EMT of AECIIs in sepsis-induced ARDS patients is different from that in patients with pneumonia-induced ARDS in the regulatory mechanism. Here, we will report for the first time that an lncRNA-ASLNC12002 is highly expressed in AECIIs of patients with sepsis-induced pneumonia and promotes EMT in AECIIs. The research results showed that the expression of ASLNC12002 in AECIIs derived from patients with sepsis-induced ARDS is significantly higher than that in normal people and pneumonia-induced ARDS patients. Mechanism research showed that ASLNC12002 can cause the inactivation of the anti-EMT pathway NR2F2/miR128-3p/Snail1 by acting as the sponge of miR128-3p. Functional experiments showed that targeted silencing of ASLNC12002 could effectively inhibit EMT progression in AECIIs of patients with sepsis-induced pneumonia by restoring NR2F2/miR128-3p/Snail1 pathway. In a word, our study shows for the first time that the inactivation of NR2F2/miR128-3p/Snail1 pathway caused by the enhanced expression of ASLNC12002 is the direct reason why AECIIs in sepsis-induced ARDS patients are prone to get EMT progress. ASLNC12002 has the potential to become a biological target for the prevention and treatment of pulmonary fibrosis in patients with sepsis-induced ARDS. At the same time, the expectation that ASLNC12002 and its related products may be used as clinical markers for the evaluation of early pulmonary fibrosis in ARDS patients should not be ignored.

Identification of a stable major-effect quantitative trait locus for pre-harvest sprouting in common wheat (Triticum aestivum L.) via high-density SNP-based genotyping - Zhi Li; Yongyan Chen; Xia Ou; Mengning Wang; Nanxin Wang; Wei Li; Yawen Deng; Yixin Diao; Zixin Sun; Qinyi Luo; Xinli Li; Liqi Zhao; et al. (Theoretical and Applied Genetics, 2022)

Genetic Diversity Analysis of the Phenotypic Traits of 215 Sugar Beet Germplasm Resources - Dali Liu; Xueqian Wang; Wangsheng Li; Jiajia Li; Wenbo Tan; Wang Xing (Sugar Tech, 2022)

A Novel Splicing Mutation c.335–1 G > A in the Cardiac Transcription Factor NKX2-5 Leads to Familial Atrial Septal Defect Through miR-19 and PYK2 - Li Jia; Dai Limeng; Tan Xiaoyin; Wang Junwen; Zhu Xintong; Xiong Gang; Bai Yun; Guo Hong (Stem Cell Reviews and Reports, 2022)

Shanghai Autism Early Development: An Integrative Chinese ASD Cohort - Yuan Dai; Yuqi Liu; Lingli Zhang; Tai Ren; Hui Wang; Juehua Yu; Xin Liu; Zilin Chen; Lin Deng; Minyi Tao; Hangyu Tan; Chu-Chung Huang; et al. (Neuroscience Bulletin, 2022)

Drought risk assessment in the coupled spatial–temporal dimension of the Sichuan Basin, China - Tan Huizhi; Lu Xiaoning; Yang Shiqi; Wang Yongqian; Li Feng; Liu Jinbao; Chen Jun; Huang Yue (Natural Hazards, 2022)

Identification of mutational signature for lung adenocarcinoma prognosis and immunotherapy prediction - Sainan Zhang; Mengyue Li; Yilong Tan; Juxuan Zhang; Yixin Liu; Wenbin Jiang; Xin Li; Haitao Qi; Lefan Tang; Ran Ji; Wenyuan Zhao; Yunyan Gu; et al. (Journal of Molecular Medicine, 2022)

Increased Expression of CD95 in CD4+ Effector Memory T Cells Promotes Th17 Response in Patients with Myasthenia Gravis - Xiaoyu Huang; Jie Zhu; Tan Liu; Fengzhan Li; Tingting Yang; Hao Li; Fei Chen; Yong Zhang; Yuzhong Wang; Linlin Fu; Chenghua Xiao; Deqin Geng (Journal of Neuroimmune Pharmacology, 2022)

Farnesoid X receptor regulates PI3K/AKT/mTOR signaling pathway, lipid metabolism, and immune response in hybrid grouper - Jia Xu; Xinzhou Yao; Xiaoyue Li; Shiwei Xie; Shuyan Chi; Shuang Zhang; Junming Cao; Beiping Tan (Fish Physiology and Biochemistry, 2022)

Clean technology investment considering synergistic effects: a case from the steel sintering process - Jianxin Guo; Xianchun Tan; Xiaoyan Meng; Yanping Li (Environment, Development and Sustainability, 2022)

Genomic Analysis and Molecular Characteristics in Carbapenem-Resistant Klebsiella pneumoniae Strains - Suying Zhao; Xingyi Qiu; Yiting Tan; Min Xu; Xiaotong Xu; Yulai Ge; Huiling Cao; Min Li; Yuxin Lin; Zhan Zhang; Lei Li; Qian Wu (Current Microbiology, 2022)

Characterization of Chlamydia muridarum TC0668 Protein: Localization, Expression, and Inflammation-Inducing Effects on Host Cell - Na Liu; Xiaofang Li; Hao Chen; Chuan Wang; Wenjing Xiang; Shui Tan; Chenchen Song; Emmanuel Wirekoh Arthur; Asamoah Maxwell; Derrick Annang; Zhou Zhou (Current Microbiology, 2022)

Implications of the discovery of rapidly deposited lacustrine sediments in the Suwalong reach of the upper Jinsha River, SE Tibetan Plateau - Yongchao Li; Jianping Chen; Chun Tan; Feifan Gu; Yiwei Zhang; Muhammad Ammar; Qing Wang (Bulletin of Engineering Geology and the Environment, 2022)

Effects of snow absence on available N pools and enzyme activities within soil aggregates in a spruce forest on the eastern Tibetan Plateau - Zhijie Li; Rüdiger Reichel; Zimin Li; Kaijun Yang; Li Zhang; Bo Tan; Rui Yin; Kerui Zhao; Zhenfeng Xu (Soil Ecology Letters, 2022)

Agricultural Applications and Potential Risks of Copper-Based Nanoagrochemicals in Crop Cultivation - Yanwanjing Liu; Weichen Zhao; Yongguang Yin; Muhammad Adeel; Noman Shakoor; Yuanbo Li; Zhiqiang Tan; Yukui Rui; Qinghua Zhang; Jingfu Liu; Baoshan Xing (Reviews of Environmental Contamination and Toxicology, 2022)

Current Situation and Ecological Effects of Microplastic Pollution in Soil - Minggu Zhang; Miaomiao Tan; Rong Ji; Ronghui Ma; Chengliang Li (Reviews of Environmental Contamination and Toxicology, 2022)

Time Domain Full Waveform Inversion Based on Gradient Preconditioning with an Angle-Dependent Weighting Factor - Dongming Xia; Peng Song; Xishuang Li; Jun Tan; Chuang Xie; Shaowen Wang; Kai Liu; Bo Zhao; Shibo Mao (Journal of Ocean University of China, 2022)

Cuproptosis identifies respiratory subtype of renal cancer that confers favorable prognosis - Kunping Li; Linyi Tan; Yuqing Li; Yinfeng Lyu; Xinyi Zheng; Haowen Jiang; Xiaohua Zhang; Hui Wen; Chenchen Feng (Apoptosis, 2022)

Land use and land cover changes in coastal and inland wetlands cause soil carbon and nitrogen loss - Lishan Tan; Zhenming Ge; Yuhuang Ji; Derrick Y. F. Lai; Stijn Temmerman; Shihua Li; Xiuzhen Li; Jianwu Tang (Global Ecology and Biogeography, 2022)
Aim Natural wetlands are widely considered important for mitigation of climate change, but they have been impacted by land use and land cover change (LULCC), often resulting in ecosystem degradation and significant changes in soil carbon (C) and nitrogen (N) dynamics. However, the impact of various LULCC types on wetland soil C and N dynamics remains unclear. Location Global. Time period 1982–2021. Major taxa studied Wetland. Methods We present a global meta‐analysis using a database of 487 sites compiled from the literature, demonstrating the response of soil C and N concentrations and stocks in coastal wetlands, riparian wetlands and peatlands to various types of LULCCs, including agricultural lands, drained wetlands, aquaculture ponds, pastures and constructed wetlands. Results The conversion of coastal wetlands, riparian wetlands and peatlands to most LULCC types decreased the mean soil C and N concentrations and stocks by 17.8 ± 10.3, 25.3 ± 13.4 and 23.2 ± 6.3%, respectively. The loss of wetland soil C owing to LULCC is estimated to cause a potential CO 2 emission of 1.8–22.8 Mg CO 2 equivalent emission/ha/year, except for conversion to constructed wetlands. The soil C and N contents were more sensitive to LULCCs, relative to the stocks. We also found that the patterns of soil C and N variations were closely related to the conversion time since completion of LULCC. After LULCC, the response of soil C and N variables was sensitive to changes in plant biomass, soil water conditions, bulk density, pH and NH 4 + ‐N concentration, with the major controlling factors varying with the conversion age. Main conclusions Our results highlight the important role of LULCC in triggering soil C and N loss in natural wetlands, which enhances the greenhouse effect. As such, our study calls for sustainable land management strategies aiming at wetland conservation as a powerful tool to mitigate climate warming.

Energy distribution law of coal–rock combined body under confining pressure effect - Guangbo Chen; Jing Zhang; Yuan Li; Fengxu Liu; Tan Li; Guohua Zhang (Acta Geophysica, 2022)

The mechanism of phosphate solubilizing of Pseudomonas sp. TC952 and its solubilizing process on TC removal - Zewen Tan; Xiuyue Yang; Jianpeng Gao; Yongtao Li; Beini Gong (Environmental Science and Pollution Research, 2022)

An Automatic Recognition Method for Fish Species and Length Using an Underwater Stereo Vision System - Yuxuan Deng; Hequn Tan; Minghang Tong; Dianzhuo Zhou; Yuxiang Li; Ming Zhu (Fishes, 2022)
Developing new methods to detect biomass information on freshwater fish in farm conditions enables the creation of decision bases for precision feeding. In this study, an approach based on Keypoints R-CNN is presented to identify species and measure length automatically using an underwater stereo vision system. To enhance the model’s robustness, stochastic enhancement is performed on image datasets. For further promotion of the features extraction capability of the backbone network, an attention module is integrated into the ResNeXt50 network. Concurrently, the feature pyramid network (FPN) is replaced by an improved path aggregation network (I-PANet) to achieve a greater fusion of effective feature maps. Compared to the original model, the mAP of the improved one in object and key point detection tasks increases by 4.55% and 2.38%, respectively, with a small increase in the number of model parameters. In addition, a new algorithm is introduced for matching the detection results of neural networks. On the foundation of the above contents, coordinates of head and tail points in stereo images as well as fish species can be obtained rapidly and accurately. A 3D reconstruction of the fish head and tail points is performed utilizing the calibration parameters and projection matrix of the stereo camera. The estimated length of the fish is acquired by calculating the Euclidean distance between two points. Finally, the precision of the proposed approach proved to be acceptable for five kinds of common freshwater fish. The accuracy of species identification exceeds 94%, and the relative errors of length measurement are less than 10%. In summary, this method can be utilized to help aquaculture farmers efficiently collect real-time information about fish length.

Financial deepening, financial innovation, and education as new determinants of green growth in China - Li Bo; Xu Yunbao; Dai Chengbo; Tan Chao; Zhao Guangde; Ahmed Usman (Environmental Science and Pollution Research, 2022)

Chemical constituents from the aerial part of Polygala tenuifolia - Yan-Gang Cheng; Jin-Yan Tan; Jian-Li Li; Shi-Hui Wang; Kai-Li Liu; Jia-Min Wang; Ying-Li Wang (Natural Product Research, 2022)

Associations of single and multiple organophosphate pesticide exposure with female infertility in the USA: data from the 2015–2018 National Health and Nutrition Examination Survey - Yingying Wu; Xueqiong Weng; Shan Liu; Yuxuan Tan; Huanzhu Liang; Yexin Li; Lin Wen; Qian Chen; Chunxia Jing (Environmental Science and Pollution Research, 2022)

Joint effect of East Asia–Pacific and Scandinavian teleconnections on summer precipitation in Southwest China - Yang Mingxin; Xiao Tiangui; Zhao Ping; Li Yong; Huang Wei; Li Yueqing; Tan Jie (Theoretical and Applied Climatology, 2022)
Based on the summer precipitation data from 328 meteorological stations in Southwest China and the monthly mean reanalysis data from the National Centers for Environmental Prediction/National Center for Atmospheric Research, the relationships of summer precipitation in Southwest China with the East Asia–Pacific (EAP) teleconnection pattern and the Scandinavian (SCA) teleconnection pattern are explored by using correlation analysis and composite analysis. The results show that the two teleconnections are significantly negatively correlated with the summer precipitation in Southwest China in the same period. The EAP teleconnection pattern and the SCA teleconnection pattern can affect the summer precipitation in Southwest China by affecting the atmospheric circulation situation in the middle and high latitudes, the north–south and east–west movement of the WPSH, and the water vapor transport in southwest China. In particular, the EAP and SCA teleconnections jointly affect the summer precipitation in Southwest China, which can be divided into four categories of configurations based on their phases, that is, (I) positive EAP + positive SCA, (II) negative EAP + negative SCA, (III) positive EAP + negative SCA, and (IV) negative EAP + positive SCA. The distribution of summer precipitation in Southwest China varies under different categories of configurations. Category I (II) corresponds to an opposite distribution pattern of precipitation anomalies between the north and south of Southwest China. In the configuration of category I(II), the cold air from high latitudes is weaker (stronger), the WPSH is more north(south) and more west(east) than the climatological mean, and the water vapor mainly comes from the Western Pacific (Bay of Bengal), thus resulting in category I(II), the opposite distribution of precipitation. While for configuration of category III(IV), no similar symmetrical distribution of precipitation anomalies can be found, and no obvious other distribution characteristics as well.

A 10-miRNA risk score-based prediction model for pathological complete response to neoadjuvant chemotherapy in hormone receptor-positive breast cancer - Chang Gong; Ziliang Cheng; Yaping Yang; Jun Shen; Yingying Zhu; Li Ling; Wanyi Lin; Zhigang Yu; Zhihua Li; Weige Tan; Chushan Zheng; Wenbo Zheng; et al. (Science China Life Sciences, 2022)

Circular RNA circCCNB1 inhibits the migration and invasion of nasopharyngeal carcinoma through binding and stabilizing TJP1 mRNA - Mengyao Zhao; Yian Wang; Fenghua Tan; Lingyun Liu; Xiangchan Hou; Chunmei Fan; Le Tang; Yongzhen Mo; Yumin Wang; Qijia Yan; Zhaojian Gong; Zheng Li; et al. (Science China Life Sciences, 2022)

Development of genetically modified sweet cherry rootstock ‘Gisela 6’ with overexpression of PcMPK3-HA gene by Agrobacterium-mediated genetic transformation - Xiaojuan Zong; Li Xu; Yue Tan; Hairong Wei (Plant Cell, Tissue and Organ Culture (PCTOC), 2022)

Phytoplankton community dynamics during Alexandrium blooms in 2019 off the Qinhuangdao coast, Bohai Sea, China - Yixuan Xie; Renye Ding; Daojun Zha; Yu Li; Guowang Yan; Yaya Zhang; Haiyan Wu; Guanchao Zheng; Zhijun Tan; Tao Jiang (Journal of Oceanology and Limnology, 2022)

Use of municipal waste incineration fly ashes (MSWI FA) in metakaolin-based geopolymer - Jiawei Tan; Hancheng Dan; Jiabin Li (Environmental Science and Pollution Research, 2022)

Fatty acid composition of macroinvertebrate scrapers in relation to environmental conditions in subtropical mountain streams - Xingzhong Wang; Jie Li; Xiang Tan; Weibo Wang; Ying Zheng (Environmental Science and Pollution Research, 2022)

Effects analysis on hydrocarbon light-off performance of a catalytic gasoline particulate filter during cold start - Bin Zhang; Xuewei Li; Qingsong Zuo; Zibin Yin; Jianping Zhang; Wei Chen; Chun Lu; Dongli Tan (Environmental Science and Pollution Research, 2022)

Effect of hydrothermal path on swelling pressure and hydraulic conductivity of compacted bentonite - Hui Li; Yunzhi Tan; Ziyang Xie; De’an Sun (Bulletin of Engineering Geology and the Environment, 2022)

mTORC1/C2 regulate spermatogenesis in Eriocheir sinensis via alterations in the actin filament network and cell junctions - Zhen-Fang Li; Shuang-Li Hao; Lan-Min Wang; Hong-Yu Qi; Jia-Ming Wang; Fu-Qing Tan; Wan-Xi Yang (Cell and Tissue Research, 2022)

Genomic characterization and pathogenicity analysis of a porcine deltacoronavirus strain isolated in western China - Zemei Wang; Shuxian Li; Yongheng Shao; Yabin Lu; Chen Tan; Yaru Cui; Guangming Ding; Yuguang Fu; Guangliang Liu; Jianing Chen; Yonghao Hu (Archives of Virology, 2022)

Complete genome sequence of Aconitum amalgavirus 1, a distinct member of the genus Amalgavirus - Jie Yang; Ping-Xiu Lan; Jin-Ming Li; Xiao-Jiao Chen; Guan-Lin Tan; Tai-Yun Wei; Ru-Hui Li; Fan Li (Archives of Virology, 2022)

Effects of climate change on the geographical distribution and potential distribution areas of 35 Millettia Species in China - Kai Zhao; Xuetong Li; Jingru Yang; Zebin Huang; Chunlian Li; Lewen Yao; Zekai Tan; Xianyi Wu; Shiyuan Huang; Yanghe Yuan; Zhengyi Hong; Qiuyang Cai; et al. (Environmental Science and Pollution Research, 2022)

Numerical Simulation of Fully Coupled Flow-Field and Operational Limitation Envelopes of Helicopter-Ship Combinations - Yihua Cao; Yihao Qin; Wenyuan Tan; Guozhi Li (Journal of Marine Science and Engineering, 2022)
Landing a helicopter to the ship flight deck is most demanding even for the most experienced pilots and modeling and simulation of the ship-helicopter dynamic interface is a substantially challenging technical problem. In this paper, a coupling numerical method was developed to simulate the fully coupled ship-helicopter flow-field under complete wind-over-deck conditions. The steady actuator disk model based on the momentum source approach and the resolved blade method based on the moving overset mesh method were employed to model the rotor. Two different ship-helicopter combinations were studied. The helicopter flight mechanics model was established and then the influences of coupled airwake on the helicopter were analyzed. Finally, based on the derived rejection criterion of safe landing and the developed numerical method, the flight envelopes for these two ship-helicopter combinations were predicted. The steady actuator disk model was found to be effective in the study of helicopter operations in the shipboard environment. The calculated flight envelopes indicate that an appropriate wind direction angle is beneficial to increasing the allowable maximum wind speed and the operating boundary is affected by the rotation direction of the main rotor.

Insights into the decolorization of mono and diazo dyes in single and binary dyes containing wastewater and electricity generation in up-flow constructed wetland coupled microbial fuel cell - Tean-Peng Teoh; Soon-An Ong; Li-Ngee Ho; Yee-Shian Wong; Nabilah Aminah Lutpi; Yoong-Ling Oon; Sing-Mei Tan; Yong-Por Ong; Kea-Lee Yap (Environmental Science and Pollution Research, 2022)

Lipid metabolism disorders of hybrid grouper (♀Epinephelus fuscointestinestatus × ♂E. lanceolatu) induced by high-lipid diet - Xiangxiang Suo; Xiaobo Yan; Beiping Tan; Simiao Pan; Tao Li; Hao Liu; Weibin Huang; Shuang Zhang; Yuanzhi Yang; Xiaohui Dong (Frontiers in Marine Science, 2022)
This study investigated the effect of lipid levels on growth, body composition, lipid metabolism enzymes activity and related genes expression in hybrid grouper (♀ Epinephelus fuscointestinestatus × ♂ E. lanceolatu ). Three diets with different lipid levels of 6% (low-lipid feed, LF), 11% (medium-lipid feed, MF) and 16% (high-lipid feed, HF) were designed and each diet was fed to triplicate groups of 30 fish each (6.73 ± 0.00g) for eight weeks. The results revealed the following. 1) The maximum weight gain rate (WGR), specific growth rate (SGR), protein efficiency ratio (PER) and the lowest feed conversion ratio (FCR) values were found in the HF group. There was no significant difference in the survival rate (SR) among the groups ( P > 0.05). 2) Condition factor (CF), hepatosomatic index (HSI) and visceralsomatic index (VSI) increased with increasing dietary lipid. 3) Crude lipid content in the whole-body and muscle increased significantly as the dietary lipid level increased ( P < 0.05). 4) Principal component analysis of fatty acids showed that sum n-3 polyunsaturated fatty acids (∑n-3PUFA)/sum n-6 polyunsaturated fatty acids (∑n-6PUFA) was significantly higher in the HF group than in the other two groups ( P < 0.05). 5) Biochemical serum indexes showed higher triglycerides (TG), total cholesterol (TC), alkaline phosphatase (AKP) and low-density lipoprotein-cholesterol (LDL-C) levels but lower high-density lipoprotein-cholesterol (HDL-C) level in the HF group. 6) Liver lipid metabolism enzymes activity and biochemical indicators showed that fish fed the MF diet had higher lipoprotein lipase (LPL), hepatic lipase (HL) and triglyceride lipase (ATGL) activity but lower fatty acid synthase (FAS) activity and very-low density lipoprotein-cholesterol (VLDL-C) level. 7) The relative expression levels of lipoprotein lipase ( lpl ), adipocyte-type fatty acid-binding protein ( a-fabp ), liver-type fatty acid-binding protein ( l-fabp ), heart-type fatty acid-binding protein ( h-fabp ) and hormone-sensitive lipase ( hsl ) genes in the fish liver were higher in the MF group with increasing dietary lipid ( P < 0.05), while the fatty acid synthase ( fas ) gene was expressed at lower relative level ( P < 0.05). 8) Histological oil-red sections of the liver showed that fish in the HF group had larger and more hepatic lipid droplets than those fed the other diets. It was concluded that fish fed the HF diet had better growth performance but this diet was not conducive to the progress of lipid metabolism, resulting in lipid accumulation and affecting the quality of the fish. This study provides useful information for the formulation of environmentally friendly and cost-effective diets for hybrid grouper.

Ground Deformation and Source Fault Model of the Mw 5.7 Xegar (Tibetan Plateau) 2020 Earthquake, Based on InSAR Observation - Chengtao Li; Qi Li; Kai Tan; Yong Huang; Xiaofei Lu (Pure and Applied Geophysics, 2022)

A Hashing-Based Framework for Enhancing Cluster Delineation of High-Dimensional Single-Cell Profiles - Xiao Liu; Ting Zhang; Ziyang Tan; Antony R. Warden; Shanhe Li; Edwin Cheung; Xianting Ding (Phenomics, 2022)

Repeated Sevoflurane Exposures in Neonatal Rats Increased the Brain Vulnerability to Future Stress Exposure and Resulted in Fear Extinction Deficit - Ben-zhen Chen; Li-hua Jiang; Ling Tan; Wen-qin Zhou; Yu-chao Shang; Fang Li; Bin Liu (Neurotoxicity Research, 2022)

Comparative Methylome Analysis Reveals Epigenetic Signatures Associated with Growth and Shell Color in the Pacific Oyster, Crassostrea gigas - Chao Tan; Chenyu Shi; Yin Li; Wen Teng; Yongjing Li; Huiru Fu; Liting Ren; Hong Yu; Qi Li; Shikai Liu (Marine Biotechnology, 2022)

Growth characteristics of acclimated strain of Chlorella vulgaris under high concentrations of ammonia nitrogen and phosphorus - X. Li; G. Luo; Z. Tan; J. Liu; L. Zhou; L. Ma; S. Yang; L. Wang; J. Wang; Y. Chen (International Journal of Environmental Science and Technology, 2022)

Genome-wide identification of polyphenol oxidase (PPO) family members in eggplant (Solanum melongena L.) and their expression in response to low temperature - Kai Xiao; Xiaohui Liu; Aidong Zhang; Dingshi Zha; WeiMin Zhu; Feng Tan; Qianru Huang; Yaru Zhou; Min Zhang; Jianyong Li; Xuexia Wu (Horticulture, Environment, and Biotechnology, 2022)

The simultaneous removal of co-contaminants pyrene and Cu (II) from aqueous solutions by Fe/Mn bimetallic functionalized mesoporous silica - Ziyang Zhang; Xiaoxian Zhang; Xinyu Peng; Zhifei Li; Hongrui Chen; Xiaoran Zhang; Yongwei Gong; Chaohong Tan; Haiyan Li (Environmental Science and Pollution Research, 2022)

Investigating the environmental impacts of coal mining using remote sensing and in situ measurements in Ruqigou Coalfield, China - Varinder Saini; Jun Li; Yinan Yang; Jinsong Li; Baoming Wang; Jun Tan (Environmental Monitoring and Assessment, 2022)

A New α-Cyclopiazonic Acid Alkaloid Identified from the Weizhou Island Coral-Derived Fungus Aspergillus flavus GXIMD 02503 - Jiamin Wang; Zhichao Li; Yanting Zhang; Chunmei Chen; Weihao Chen; Chenghai Gao; Yonghong Liu; Yanhui Tan; Xiaowei Luo (Journal of Ocean University of China, 2022)

RsmA3 modulates RpoS through the RetS‐Gac‐Rsm signalling pathway in response to H 2 O 2 stress in the phytopathogen Pseudomonas syringae - Xun Yu; Cui Meng; Xiaocheng Tan; Yuwei Su; Zhiping Cao; Tzann‐Shun Hwang; Lin Li (Environmental Microbiology, 2022)
Reactive oxygen species are a fatal challenge to the plant pathogenic bacterium Pseudomonas syringae . In this study, we reveal that the global regulatory protein RsmA3 from the RetS‐Gac/Rsm signalling pathway modulates RpoS in the early‐log growth phase in the P . syringae wild‐type strain MB03, thereby regulating oxidative tolerance to H 2 O 2 and ultimately affecting pathogenicity to the host plant. Following increased H 2 O 2 by external addition or endogenous induction by menadione, the resistance of the mutant strain Δ retS to H 2 O 2 is significantly enhanced due to rapid increases in the transcription of Rsm‐related non‐coding small RNAs (nc sRNAs), a sigma factor RpoS, and H 2 O 2 ‐detoxifying enzymes. Moreover, the Δ retS mutant is significantly less pathogenic in cucumber leaves. Seven Rsm‐related nc sRNAs (namely, rsmZ , rsmY and rsmX 1–5 ) show functional redundancy in the RetS‐Gac‐Rsm signalling pathway. External addition of H 2 O 2 stimulates increases in the transcription of both rsmY and rsmZ . Thus, we propose a regulatory model of the RetS‐Gac‐Rsm signalling pathway in P . syringae MB03 for the regulation of H 2 O 2 tolerance and phytopathogenicity in the host plant.

The responses and detoxification mechanisms of dark septate endophytes (DSE), Exophiala salmonis, to CuO nanoparticles - Yihui Ban; Jiayuan Tan; Yang Xiong; Xiantong Mo; Wenxuan Li; Chenyue Jia; Yiwen Ding; Zhouying Xu (Environmental Science and Pollution Research, 2022)

Tea saponin enhanced bioleaching of Fusarium solani to remove hexavalent chromium from soil - Enzhi Zhang; Huan Yan; Cong Li; Shaolin Tan; Shijin Chen; Huanfang Gao (Environmental Science and Pollution Research, 2022)

Financial integration and renewable energy consumption in China: do education and digital economy development matter? - Tan Chao; Xu Yunbao; Dai Chengbo; Li Bo; Sana Ullah (Environmental Science and Pollution Research, 2022)

3D food printing: Applications of plant-based materials in extrusion-based food printing - Mingshuang Wang; Dongnan Li; Zhihuan Zang; Xiyun Sun; Hui Tan; Xu Si; Jinlong Tian; Wei Teng; Jiaxin Wang; Qi Liang; Yiwen Bao; Bin Li; et al. (Critical Reviews in Food Science and Nutrition, 2022)

The environmental cost of tax administration: evidence from a regression discontinuity design in China - Baocong Huang; Guangrong Tan; Renrui Xiao; Jin Li (Environmental Science and Pollution Research, 2022)

Two new organic acids from Portulaca oleracea L. and their anti-inflammatory and anticholinesterase activities - Peishan Liu; Lingling Wang; Huanfeng Li; Lishuang Tan; Xixiang Ying; Baozhao Ju (Natural Product Research, 2022)

Advancements of nature nanocage protein: preparation, identification and multiple applications of ferritins - Han Li; Xiaoyu Xia; Xiaoyi Tan; Jiachen Zang; Zhenyu Wang; Hesham R. EI-Seedi; Ming Du (Critical Reviews in Food Science and Nutrition, 2022)

Lipid nutritional quality of marine and freshwater bivalves and their aquaculture potential - Karsoon Tan; Hongkuan Zhang; Shengkang Li; Hongyu Ma; Huaiping Zheng (Critical Reviews in Food Science and Nutrition, 2022)

Genetic Analysis of HSP40/DNAJ Family Genes in Parkinson’s Disease: a Large Case-Control Study - Kailin Zhang; Hongxu Pan; Yuwen Zhao; Yige Wang; Qian Zeng; Xun Zhou; Runcheng He; Xiaoxia Zhou; Yaqin Xiang; Zhou Zhou; Yu Li; Qian Xu; et al. (Molecular Neurobiology, 2022)

Effect of Reactive EGCs on Intestinal Motility and Enteric Neurons During Endotoxemia - Na Li; Jing Xu; Hui Gao; Yuxin Zhang; Yansong Li; Haiqing Chang; Shuwen Tan; Shuang Li; Qiang Wang (Journal of Molecular Neuroscience, 2022)

Two new clerodane diterpenoids and a new pyran-2-one derivative with anti-neuroinflammatory activities from Croton crassifolius - Zhi-Peng Ling; Qing Tang; Can-Jie Li; Jin-Lin Tan; Hai-Yue Zhao; Yi-Kun Hao; Zhao-Chun Zhan; Zhong-Nan Wu; Yu-Bo Zhang; Qing Zheng; Guo-Cai Wang (Journal of Natural Medicines, 2022)

Molecular detection of spotted fever group rickettsiae in hedgehogs (Erinaceus amurensis) and hedgehog-attached ticks in Xuyi County, Southeast China - Changqiang Zhu; Lele Ai; Yong Qi; Yunsheng Liu; Hong Li; Fuqiang Ye; Qiuwei Wang; Yizhe Luo; Weilong Tan; Chunmeng Shi (Experimental and Applied Acarology, 2022)
Tick-borne diseases like Rickettsia , Anaplasma and Ehrlichia are widespread infectious zoonoses that threaten the health of both humans and animals worldwide. Ticks and their hosts, such as hedgehogs, can play a crucial role in transmitting tick-borne diseases and the cycle of Rickettsia . To investigate the presence and identity of Rickettsia in hedgehogs and hedgehog-attached ticks in Xuyi County, Southeast China, 114 ticks were collected from 45 hedgehogs captured totally. Via morphological and molecular methods, all these ticks were identified as two species: Haemaphysalis flava (110/114, 96.5%) and Haemaphysalis longicornis (4/114, 3.5%). Rickettsia spp. were genotypically characterized by PCR targeting rrs , gltA , ompA , ompB , and sca4 gene fragments. The prevalence of spotted fever group rickettsiae (SFGR) infection found in hedgehogs and ticks was 17.8% (8/45) and 78.1% (89/114), respectively. Phylogenetic analyses demonstrated that those Rickettsia spp. belong to two species: Rickettsia heilongjiangensis ( R. heilongjiangensis XY-1) and a potential new species, Candidatus Rickettsia xuyiensis XY-2. The present study gave the first evidence of R. heilongjiangensis and Candidatus R. xuyiensis in ticks and hedgehogs of Southeast China. Our findings suggest that hedgehogs might be involved in the natural transmission cycle of Rickettsia species.

Ethnicity evaluation of ferric pyrophosphate citrate among Asian and Non-Asian populations: a population pharmacokinetics analysis - Lingxiao Zhang; Liangying Gan; Kexin Li; Panpan Xie; Yan Tan; Gang Wei; Xiaojuan Yuan; Raymond Pratt; Yongchun Zhou; Ai-Min Hui; Yi Fang; Li Zuo; et al. (European Journal of Clinical Pharmacology, 2022)
Purpose To evaluate the potential ethnic differences of ferric pyrophosphate citrate (FPC, Triferic) in healthy subjects and patients with hemodialysis-dependent stage 5 chronic kidney disease (CKD-5HD) and identify covariates that may influence pharmacokinetics (PK) of FPC. Methods Data were collected from 2 Asian and 4 non-Asian clinical studies involving healthy subjects and CKD-5HD patients. Three population PK models were developed: M1 for intravenous (IV) administration of FPC in healthy subjects; M2 for dialysate administration of FPC in CKD-5HD patients; M3 for pre-dialyzer administration of FPC in CKD-5HD patients. All the models were fitted to concentration versus time data of FPC using the nonlinear mixed effect approach with the NONMEM ® program. All statistical analyses were performed using SAS version 9.4. Results In total, 26 Asians and 65 non-Asians were included in the final model analysis database. Forty healthy subjects were administered FPC via intravenous (IV) route and 51 patients with CKD-5HD via dialysate ( N = 50) and pre-dialyzer blood circuit administration ( N = 51). The PK parameters of FPC IV were similar. The population PK model showed good parameter precision and reliability as shown by model evaluation, and no relevant influence of ethnicity on PK parameters was observed. In healthy subjects, the maximum observed plasma concentration (C max ) and area under the plasma concentration–time curve (AUC) decreased with increase in lean body mass (LBM) and the average serum total iron at 6 h before the baseline period (Fe av ), whereas, in both patient populations, C max and AUC decreased with increase in LBM and decrease in Fe baseline . Other factors such as gender, age, Fe av , and ethnicity had no influence on PK exposures in patients. The influence of LBM on PK exposures in patients was smaller than that in healthy subjects (ratio of AUC 0-24 for the 5th [68 kg] and 95th [45 kg] patient’s LBM was almost 1). The influence of Fe av and LBM on PK exposures was < 50%. Conclusion The population pharmacokinetics model successfully described the PK parameters of FPC in healthy subjects and CKD-5HD patients and were comparable between Asian and non-Asian populations.

A comparative study on adsorption of cadmium and lead by hydrochars and biochars derived from rice husk and Zizania latifolia straw - Xinyuan Zhang; Zixiang Gao; Xiaoping Fan; Li Tan; Yishun Jiang; Wanning Zheng; Fengxiang X. Han; Yongchao Liang (Environmental Science and Pollution Research, 2022)

The estimation of influencing factors for carbon emissions based on EKC hypothesis and STIRPAT model: Evidence from top 10 countries - Ellen Thio; MeiXuen Tan; Liang Li; Muhammad Salman; Xingle Long; Huaping Sun; Bangzhu Zhu (Environment, Development and Sustainability, 2022)

Prediction and analysis of the soil organic matter distribution with the spatiotemporal kriging method - Yong Yang; Hao Li; Shudan Deng; Xue Yang; Mingxia Wang; Wenfeng Tan; Zhengyu Wu; Qinglong Wang; Yuzhi Zhou (Earth Science Informatics, 2022)

Effects of straw returning on soil moisture and maize yield in semi-humid area - Lihua Zhang; Hongxiang Zhao; Chen Xu; Weiping Yan; Ning Sun; Guobo Tan; Jiang Yu; Xiangmeng Meng; Fei Li; Shaofeng Bian (Cereal Research Communications, 2022)

Cardiac Remodelling Following Cancer Therapy: A Review - Tan Panpan; Du Yuchen; Shi Xianyong; Liu Meng; He Ruijuan; Dong Ranran; Zhang Pengyan; Li Mingxi; Xie Rongrong (Cardiovascular Toxicology, 2022)

Multi-walled Carbon Nanotubes Remediate the Phytotoxicity of Quinclorac to Tomato - Jingyu Zhao; Shuo Tan; Hui Li; Yao Wang; Ting Yao; Lejun Liu; Kailin Liu (Bulletin of Environmental Contamination and Toxicology, 2022)

Substituting Fish Meal with a Bacteria Protein (Clostridium autoethanogenum Protein) Derived from Industrial-Scale Gas Fermentation: Effects on Growth and Gut Health of Juvenile Large Yellow Croakers (Larimichthys crocea) - Jian Zhang; Yanzou Dong; Kai Song; Ling Wang; Xueshan Li; Kangle Lu; Beiping Tan; Chunxiao Zhang (Fishes, 2022)
This study was conducted to investigate the effects of Clostridiumautoethanogenum protein (CAP) replacement for fish meal (FM) on growth performance, digestive enzyme activity, humoral immunity and liver and intestinal health in large yellow croakers (Larimichthys crocea). Four experimental diets were formulated by replacing FM with CAP at different levels—0% (CAP0), 15% (CAP15), 30% (CAP30) and 45% (CAP45). Triplicate groups of juveniles (initial weight = 11.86 ± 0.13 g) were fed the test diets to apparent satiation two times daily for eight weeks. There was no significant difference in final body weight (FBW), weight gain rate (WG) and feed efficiency (FE) between CAP0 and CAP15. However, compared to the CAP0, CAP30 and CAP45 significantly reduced FBW, WG and LDR (p 0.05). Compared to CAP0, CAP30 and CAP45 significantly reduced serum C4 concentration (p

In vitro effects of Eucommia ulmoides and its active components on the growth, lipid metabolism and collagen metabolism of grass carp ( Ctenopharyngodon idellu s) hepatocyte and intramuscular fibroblast - Hang Yang; Zhen Xu; Sumei Tan; Chunyan Zhang; Xiaoqin Li; Xiangjun Leng (Journal of Fish Biology, 2022)
Two experiments were conducted to investigate the in vitro effects of Eucommia ulmoides ( E. ulmoides ) and its active components on the growth, lipid metabolism and collagen metabolism of grass carp's ( Ctenopharyngodon idellus ) hepatocytes and intramuscular fibroblasts. In experiments 1 and 2 (Expt. 1, 2), hepatocytes and intramuscular fibroblasts were treated with 2.5, 5, 10, 20, 40 and 80 μg ml –1 of Eucommia bark extract (EBE), Eucommia leaf extract (ELE), pinoresinol diglucoside (PDG), chlorogenic acid (CGA), quercetin (QC) and aucubin (AU) for 24 h, respectively, then the cell growth, lipid and collagen metabolism‐related gene expressions were evaluated. The results showed that the cell proliferation rate of hepatocytes and intramuscular fibroblasts was significantly improved by the supplementation of EBE, ELE, CGA, QC and AU. Moreover, triglyceride concentration of hepatocytes was significantly decreased by the EBE, ELE, CGA and QC supplementations compared to the control. Meanwhile, EBE, ELE, CGA, QC and AU supplementations significantly upregulated the relative gene expressions of insulin‐like growth factor‐1 ( igf1 ), protein kinase B ( akt ), target of rapamycin ( tor ) and eukaryotic initiation factor 4E binding protein 1 ( 4ebp1 ) in hepatocytes, and ribosomal protein S6 kinase 1 ( s6k1 ) transcription was significantly activated by ELE, CGA and QC supplementations. Nonetheless, phosphatidylinositol 3‐kinase ( pi3k ) was unaffected by any of the supplements. In addition, the mRNA expressions of genes associated with lipid metabolism (peroxisome proliferator activated receptor α pparα , carnitine palmitoyltransferase 1 cpt1 , adipose triglyceride lipase atgl , hormone‐sensitive lipase hsl , peroxisome proliferator activated receptor γ pparγ ) were significantly upregulated by EBE, ELE, CGA and QC. In intramuscular fibroblasts, the EBE, ELE, CGA, QC and AU supplementations significantly increased in vitro hydroxyproline concentrations, promoted the relative expressions of transforming growth factor‐β1 ( tgfβ1 ), connective tissue growth factor ( ctgf ), collagen type I alpha 1/2 chain ( col1a1 , col1a2 ), lysine oxidase ( lox ) and tissue inhibitor of matrix metalloproteinase‐2 ( timp2 ), and decreased matrix metalloproteinase‐2 ( mmp2 ) gene expression. Also, the gene expressions of drosophila mothers against decapentaplegic protein 2/4 ( smad2 , smad4 ) and proline hydroxylase ( phd ) were significantly upregulated by ELE, CGA, QC and AU supplementations. Based on the present in vitro results of grass carp, EBE, ELE, CGA, QC and AU improved the growth and lipid metabolism (except AU) in hepatocytes, and promoted the collagen deposition in intramuscular fibroblast, which is partly attributed to the signalling pathways of AKT/TOR, PPARα and TGF‐β/Smads/CTGF.

Vertical distribution of planktonic ostracods (Halocyprididae) in the northeastern and central South China Sea: Significance of large‐sized species in deep waters - Tongchen Liao; Yehui Tan; Hui Liu; Linghui Yu; Kaizhi Li (Fisheries Oceanography, 2022)
The vertical distribution of species richness, abundance and biomass of planktonic ostracods down to a depth of 1000 m were studied in the northeastern South China Sea (NESCS) during March and in the central South China Sea (CTSCS) during September 2016. A total of 47 species of halocyprids were identified, with 46 species recorded in the NESCS and 28 species in the CTSCS. Most of the species observed were concentrated in the mesopelagic zone (200–1000 m), but the majority of species abundance and biomass occurred in the 25 m to 300 m water column. Results of statistical analysis showed that the vertical distribution of planktonic ostracods was associated with chlorophyll a concentration and sampling depth. The high abundance and species richness of ostracods in the NESCS were probably influenced by the Kuroshio intrusion and eddies leading to high levels of chlorophyll a concentration. The biomass of large‐sized individuals with low abundance is equal to or larger than, the extremely small‐sized individuals with high abundance, particularly in deep layers. The body sizes of planktonic ostracods were found to increase from surface to deeper water layers, indicating a trend of greater body length and higher biomass of ostracods in deep sea.

Multitrophic diversity and biotic associations influence subalpine forest ecosystem multifunctionality - Ya‐Huang Luo; Marc W. Cadotte; Jie Liu; Kevin S. Burgess; Shao‐Lin Tan; Lin‐Jiang Ye; Jia‐Yun Zou; Zhong‐Zheng Chen; Xue‐Long Jiang; Juan Li; Kun Xu; De‐Zhu Li; et al. (Ecology, 2022)
Biodiversity across multiple trophic levels is required to maintain multiple ecosystem functions. Yet it remains unclear how multitrophic diversity and species interactions regulate ecosystem multifunctionality. Here, combining data from 9 different trophic groups (including trees, shrubs, herbs, leaf mites, small mammals, bacteria, pathogenic fungi, saprophytic fungi, and symbiotic fungi) and 13 ecosystem functions related to supporting, provisioning, and regulating services, we used a multitrophic perspective to evaluate the effects of elevation, diversity, and network complexity on scale‐dependent subalpine forest multifunctionality. Our results demonstrated that elevation and soil pH significantly modified species composition and richness across multitrophic groups and influenced multiple functions simultaneously. We present evidence that species richness across multiple trophic groups had stronger effects on multifunctionality than species richness at any single trophic level. Moreover, biotic associations, indicating the complexity of trophic networks, were positively associated with multifunctionality. The relative effects of diversity on multifunctionality increased at the scale of the larger community compared to a scale accounting for neighboring interactions. Our results highlight the paramount importance of scale‐ and context‐dependent multitrophic diversity and interactions for a better understanding of mountain ecosystem multifunctionality in a changing world.

Effects of vitamin E supplementation of a high-lipid diet on the growth and biochemical parameters of hybrid groupers (♀ Epinephelus fuscoguttatus × ♂ E. lanceolatus) - Weibin Huang; Xiaobo Yan; Hao Liu; Beiping Tan; Xiangxiang Suo; Simiao Pan; Tao Li; Yuanzhi Yang; Xiaohui Dong (Frontiers in Marine Science, 2022)
There is a trend towards using high-lipid diets in aquaculture, which can be optimized by using certain additives. This study investigated the effect of vitamin E (VE) supplementation of a high-lipid diet on the growth, serum and liver biochemical indexes, hepatic histology, and lipid metabolism of hybrid groupers (♀ Epinephelus fuscoguttatus × ♂ Epinephelus lanceolatus ). Six groups of iso-protein (50.23%) and iso-lipidic high-lipid (15.36%) experimental diets were prepared by adding VE at concentrations of 49.6 (basic diet, controls), 100, 110, 163, 206, and 245 mg/kg. Each treatment consisted of three replicates and 30 fish (10.20 ± 0.02 g) in an 8-week feeding experiment. The results show that 1) compared with controls, growth performance was not affected by VE addition. However, the weight gain rate (WGR) and specific growth rate (SGR) were significantly lower in the high-VE group (245 mg/kg) than in the 163 and 206 mg/kg groups. 2) Compared with controls, VE significantly increased the contents of alpha-tocopherol in the liver and muscle. 3) Adding VE can reduce the fatty livers caused by high-lipid diets and significantly reduce total serum cholesterol, reduce the activity of lipid synthesis enzymes, and significantly increase the activity of lipolytic enzymes in the liver. 4) Compared with controls, appropriate amounts of VE significantly increased the expressions of the liver lipid-metabolism-related genes PPAR-α , PPAR-β , PPAR-γ , H-FABP , A-FABP , and L-FABP . Based on observations of lipid metabolism enzyme activity, histological sections, and lipid-metabolism-related gene expression, we conclude that the addition of 163–206 mg/kg VE to a high-lipid diet can promote lipid metabolism in groupers.

An investigation into residents' willingness to pay for vertical greening in China - Yang Tan; Hiroatsu Fukuda; Li Zhang; Shuai Wang; Weijun Gao; Zhonghui Liu (Urban Ecosystems, 2022)

An alanine to valine mutation of glutamyl-tRNA reductase enhances 5-aminolevulinic acid synthesis in rice - Meng Jiang; Shang Dai; Yun-Chao Zheng; Rui-Qing Li; Yuan-Yuan Tan; Gang Pan; Ian Max Møller; Shi-Yong Song; Jian-Zhong Huang; Qing-Yao Shu (Theoretical and Applied Genetics, 2022)

Identification and characterization of the novel leaf rust resistance gene Lr81 in wheat - Xiangyang Xu; James Kolmer; Genqiao Li; Chengcheng Tan; Brett F. Carver; Ruolin Bian; Amy Bernardo; Guihua Bai (Theoretical and Applied Genetics, 2022)

Causal Effect of Genetically Determined Blood Copper Concentrations on Multiple Diseases: A Mendelian Randomization and Phenome-Wide Association Study - Xiuming Feng; Wenjun Yang; Lulu Huang; Hong Cheng; Xiaoting Ge; Gaohui Zan; Yanli Tan; Lili Xiao; Chaoqun Liu; Xing Chen; Zengnan Mo; Longman Li; et al. (Phenomics, 2022)

Aromatic-turmerone ameliorates DSS-induced ulcerative colitis via modulating gut microbiota in mice - Chunlian Li; Weicheng Zhang; Xianyi Wu; Qiuyang Cai; Zekai Tan; Zhengyi Hong; Shiyuan Huang; Yanghe Yuan; Lewen Yao; Lanyue Zhang (Inflammopharmacology, 2022)

Occurrence characteristics and health risk assessment of per- and polyfluoroalkyl substances from water in residential areas around fluorine chemical industrial areas, China - Jiaxi Tang; Yongle Zhu; Yu Li; Biao Xiang; Ting Tan; Linyou Lv; Qing Luo (Environmental Science and Pollution Research, 2022)

FTO mediated ERBB2 demethylation promotes tumor progression in esophageal squamous cell carcinoma cells - Fangfang Zhao; Fangfang Ge; Minghua Xie; Zhenyu Li; Chunbao Zang; Lingsuo Kong; Youguang Pu; Xucai Zheng; Yiao Tan (Clinical & Experimental Metastasis, 2022)
N 6 -methyladenosine (m 6 A) is the most prevalent and internal modification that occurs in the messenger RNAs of eukaryotes. However, knowledge of the impact of these modifications on gene expression regulation remains limited. By using the in vitro MeRIP-seq and RNA-seq assays, we discovered that the mRNA demethylase FTO was significantly up-regulated in esophageal squamous cell carcinoma (ESCC) tissues and cells. Knockdown of FTO drastically suppressed the proliferation, migration, and invasion of ESCC cells. Furthermore, by using transcriptome-wide m 6 A-seq and RNA-seq assays, we identified ERBB2 is the target of FTO, which acts in concert in ESCC tumorigenesis and metastasis. Moreover, loss and gain functional studies suggested that the m 6 A reader YTHDF1 stabilizes ERBB2 mRNA via decoding the m 6 A modification. All these results uncovered a new signaling cascade, including FTO, YTHDF1, and ERBB2, which finely regulates the ESCC progression.

Dynamic response of the inhomogeneous pavement structure containing a buried fault zone under the moving aircraft loads - Jiawei Wan; Bin Li; Yang Gao; Chengxuan Tan; Chengjun Feng; Peng Zhang (Bulletin of Engineering Geology and the Environment, 2022)

History of suicide attempts associated with the thinning right superior temporal gyrus among individuals with schizophrenia - Yi Yin; Jinghui Tong; Junchao Huang; Baopeng Tian; Song Chen; Shuping Tan; Zhiren Wang; Fude Yang; Yongsheng Tong; Fengmei Fan; Peter Kochunov; Neda Jahanshad; et al. (Brain Imaging and Behavior, 2022)

Resting-state functional connectivity of the sensory/somatomotor network associated with sleep quality: evidence from 202 young male samples - Youling Bai; Jiawen Tan; Xiaoyi Liu; Xiaobing Cui; Dan Li; Huazhan Yin (Brain Imaging and Behavior, 2022)

Brain structural changes in regions within the salience network in patients with functional constipation - Zhenzhen Jia; Guanya Li; Yang Hu; Hao Li; Wenchao Zhang; Jia Wang; Lei Zhang; Zongxin Tan; Shuai Lv; Karen M. von Deneen; Shijun Duan; Guangbin Cui; et al. (Brain Imaging and Behavior, 2022)

Fertility conversion between cytoplasmic maintainer lines and restorer lines through molecular marker-assisted selection in pepper (Capsicum annuum L.) - Fu-Sen Ren; Hai-Feng Yang; Yu-Shun Jiao; Rui-Ping Zhang; Zhi-Wei Guo; He-Juan Liu; Qiang Sun; Xi-Jun Li; Xiu-Fang Tan; Bei Zhang; Jun-Qi Zhen; Yan-Qi Dong (Biologia, 2022)

Enhancing or inhibiting apoptosis? The effects of ucMSC-Ex in the treatment of different degrees of traumatic pancreatitis - Zhao Zhirong; Han Li; He Yiqun; He Chunyang; Zhou Lichen; Tan Zhen; Wang Tao; Dai Ruiwu (Apoptosis, 2022)

Effects of Plant Community Type on Soil Methane Flux in Semiarid Loess Hilly Region, Central Gansu Province, China - Chuanjie Yang; Guang Li; Lijuan Yan; Weiwei Ma; Jiangqi Wu; Yan Tan; Shuainan Liu; Shikang Zhang (Advances in Atmospheric Sciences, 2022)

Deterioration law of intermittent jointed sandstone mechanical properties under water–rock interaction - Guangbo Chen; Yuan Li; Tan Li; Guohua Zhang (Acta Geophysica, 2022)

Review of the State-of-Art of MPS Method in Ocean Engineering - Zhe Sun; Li-Yuan Dou; Si-Yuan Tan; Zi-Kai Xu; Kamal Djidjeli; Yan Zhou (Journal of Marine Science and Engineering, 2022)
When dealing with the complex deformation of free surface such as wave breaking, traditional mesh-based Computational Fluid Dynamics (CFD) methods often face problems arising alongside grid distortion and re-meshing. Therefore, the meshless method became robust for treating large displaced free surface and other boundaries caused by moving structures. The particle method, which is an important branch of meshless method, is mainly divided into the Smoothed Particle Hydrodynamics (SPH) and Moving Particle Semi-implicit (MPS) methods. Different from the SPH method, which involves continuity and treat density as a variable when building kernel functions, the kernel function in the MPS method is a weight function which treats density as a constant, and the spatial derivatives are discretized by establishing the gradient operator and Laplace operator separately. In other words, the first- or second-order continuity of the kernel functions in the MPS method is not a necessity as in SPH, though it might be desirable. At present, the MPS method has been successfully applied to various violent-free surface flow problems in ocean engineering and diverse applications have been comprehensively demonstrated in a number of review papers. This work will focus on algorithm developments of the MPS method and to provide all perspectives in terms of numerical algorithms along with their pros and cons.

Provenance and Palaeogeomorphology study of the southwestern North China Craton during Middle-Late Triassic and its geological implication - Cong Tan; Zhuang Ruan; Bingsong Yu; Zhixin Li; Ce Liu; Lei Zhao; Jianzhong Li; Peng Jia (International Geology Review, 2022)

Comparison of Behavior, Histology and ImpL2 Gene Expression of Octopus sinensis Under Starvation and Senescence Conditions - Li Bian; Fenghui Li; Qing Chang; Changlin Liu; Jie Tan; Shengnong Zhang; Xuemei Li; Meishuai Li; Yikang Sun; Rongjing Xu; Siqing Chen (Frontiers in Marine Science, 2022)
Offshore cephalopods usually experience a short and extreme senescence process at the end of their lives. Unique behaviors such as brooding and fasting occur during this period. The cause of senescent cephalopod death is still unknown. Excessive energy consumption under prolonged starvation is one possible reason for death. A comparison analysis between normal starvation and senescence may provide valuable information to deepen our understanding of the senescence process of cephalopods. In this study, a comparison of behavior, histology and expression of a candidate senescence-specific gene (Imaginal morphogenesis protein-Late 2, ImpL2) of female Octopus sinensis under normal starvation and senescence was conducted. The females in the starvation group had similar behaviors, histology and ImpL2 expression level to the control group. The females in the senescence group exhibited typical behaviors and symptoms of senescent octopus, including fasting and unhealed lesions on the skin. Moreover, swimming and grasping ability was weakened in senescent individuals. The muscle tissue in the mantle and arm of senescent females showed a histolytic appearance. The secretory cells and their microvilli in the digestive gland gradually degraded and disappeared during senescence. The expression level of ImpL2 gene significantly changes in multiple organs of senescent females. The results showed that O. sinensis underwent different physiological and molecular processes during starvation and senescence. Starvation alone could not lead to senescent symptoms in the octopus. Tissue degeneration in the mantle, arm and digestive gland would increase the death risk of the octopus.

Chemical constituents from the Streptomyces morookaensis strain Sm4-1986 - Gui-Yun Wu; Zhi-Yan Zhu; Xiao Zhang; Miao-Miao Wang; Jian-Xiong Li; Ying-Jie Hu; Hai-Bo Tan (Natural Product Research, 2022)

First report of Nigrospora aurantiaca causing leaf spot on Pandanus amaryllifolius in Malaysia - Ying Wei Khoo; Hui Teng Tan; Yam Sim Khaw; Shi-Fang Li; Khim Phin Chong (Journal of Plant Pathology, 2022)

Formation of the Looming-evoked Innate Defensive Response during Postnatal Development in Mice - Shanping Chen; Huiying Tan; Zhijie Wang; Yu-ting Tseng; Xiaotao Li; Liping Wang (Neuroscience Bulletin, 2022)

Multiple transcriptome analysis of Piwil2-induced cancer stem cells, including piRNAs, mRNAs and miRNAs reveals the mechanism of tumorigenesis and development - Xiaojun Tan; Tao Mi; Zhaoxia Zhang; Liming Jin; Zhang Wang; Xin Wu; Jinkui Wang; Mujie Li; Chenghao Zhanghuang; Dawei He (Molecular Biology Reports, 2022)

STK11 overexpression prevents glucocorticoid-induced osteoporosis via activating the AMPK/SIRT1/PGC1α axis - Jiao Xiao; Wenjin Li; Guojuan Li; Jiankai Tan; Na Dong (Human Cell, 2022)

Effects of various spectral compositions on micro-polluted water purification and biofuel feedstock production using duckweed - Qi Li; Zhuolin Yi; Guili Yang; Yaliang Xu; Yanling Jin; Li Tan; Anping Du; Kaize He; Hai Zhao; Yang Fang (Environmental Science and Pollution Research, 2022)

COD/TN ratios shift the microbial community assembly of a pilot-scale shortcut nitrification-denitrification process for biogas slurry treatment - Yangwu Chen; Huan Wang; Xingdong Gao; Xin Li; Shiyang Dong; Houzhen Zhou; Zhouliang Tan (Environmental Science and Pollution Research, 2022)

An ion-imprinted imidazole-functionalized ordered mesoporous silica for selective removal of chromium(VI) from electroplating effluents - Shuibin Cen; Lan Yang; Ruimin Li; Shengzhao Gong; Jiean Tan; Lixi Zeng (Environmental Science and Pollution Research, 2022)

Alterations in Functional and Structural Connectivity of Basal Ganglia Network in Patients with Obesity - Zongxin Tan; Yang Hu; Gang Ji; Guanya Li; Yueyan Ding; Wenchao Zhang; Jia Wang; Zhenzhen Jia; Lei Zhang; Hao Li; Karen M. von Deneen; Yu Han; et al. (Brain Topography, 2022)

Whole-transcriptome sequencing identifies key mRNAs, miRNAs, lncRNAs, and circRNAs associated with unexplained recurrent pregnancy loss - Yan Wang; Qing Cheng; Zhengyi Xia; Ran Zhou; Yiming Li; Lulu Meng; Qing Xu; Jianxin Tan; Zhengfeng Xu (Cell and Tissue Research, 2022)

High‐resolution mapping of the global silicate weathering carbon sink and its long‐term changes - Chaojun Li; Xiaoyong Bai; Qiu Tan; Guangjie Luo; Luhua Wu; Fei Chen; Huipeng Xi; Xuling Luo; Chen Ran; Huan Chen; Sirui Zhang; Min Liu; et al. (Global Change Biology, 2022)
Climatic and non‐climatic factors affect the chemical weathering of silicate rocks, which in turn affects the CO 2 concentration in the atmosphere on a long‐term scale. However, the coupling effects of these factors prevent us from clearly understanding of the global weathering carbon sink of silicate rocks. Here, using the improved first‐order model with correlated factors and non‐parametric methods, we produced spatiotemporal data sets (0.25° × 0.25°) of the global silicate weathering carbon‐sink flux (SCSF α ) under different scenarios (SSPs) in present (1950–2014) and future (2015–2100) periods based on the Global River Chemistry Database and CMIP6 data sets. Then, we analyzed and identified the key regions in space where climatic and non‐climatic factors affect the SCSF α . We found that the total SCSF α was 155.80 ± 90 Tg C yr −1 in present period, which was expected to increase by 18.90 ± 11 Tg C yr −1 (12.13%) by the end of this century. Although the SCSF α in more than half of the world was showing an upward trend, about 43% of the regions were still showing a clear downward trend, especially under the SSP2‐4.5 scenario. Among the main factors related to this, the relative contribution rate of runoff to the global SCSF α was close to 1/3 (32.11%), and the main control regions of runoff and precipitation factors in space accounted for about 49% of the area. There was a significant negative partial correlation between leaf area index and silicate weathering carbon sink flux due to the difference between the vegetation types. We have emphasized quantitative analysis the sensitivity of SCSF α to critical factors on a spatial grid scale, which is valuable for understanding the role of silicate chemical weathering in the global carbon cycle.

Spatial and Seasonal Variations in the Stable Isotope Values and Trophic Positions of Dominant Zooplankton Groups in Jiaozhou Bay, China - Zhixin Ke; Ruofei Li; Danting Chen; Chunyu Zhao; Yehui Tan (Frontiers in Marine Science, 2022)
The spatial and seasonal distributions of stable carbon and nitrogen isotopes (δ 13 C and δ 15 N) in dominant zooplankton groups were investigated in Jiaozhou Bay. Zooplankton δ 13 C values ranged from −22.89‰ to −15.86‰, and δ 15 N values ranged from 3.18‰ to 13.57‰, respectively. The δ 13 C and δ 15 N values generally followed the order of small zooplankton < large calanoids < small Sagitta < large Sagitta . Spatial distribution patterns of zooplankton δ 13 C and δ 15 N values varied in different seasons. Our results suggested that the spatial variation of δ 13 C was mainly controlled by terrigenous organic matter (OM) input and phytoplankton biomass, but water temperature may have played a key role in the seasonal variation of δ 13 C. In spring, the high phytoplankton biomass might increase the δ 13 C value of small zooplankton in the inner bay. During other seasons, the δ 13 C values of zooplankton generally increased from the inner bay to the outer bay, which might be associated with the influence of 13 C-depleted terrigenous OM carried by the river discharge. Small zooplankton stable isotope values were significantly correlated with that of particulate organic matter (POM). The influence of anthropogenic nutrient input on isotopic baseline can be cascaded to the zooplankton, and the effect might be weak at higher trophic levels. The Bayesian standard ellipse areas of dominant zooplankton groups were generally smallest in the winter, suggesting a narrow niche width during that time. The niche partition between small zooplankton, large calanoids, and Sagitta was most distinct in winter, and followed by summer. The relative trophic level of Sagitta ranged from 2.23 to 4.01, which generally declined from the inner bay to the outer bay during the spring, autumn, and winter seasons. High anthropogenic nutrient loading might reduce the difference in trophic niches among zooplankton groups. This study provided detailed information on the distribution of zooplankton δ 13 C and δ 15 N in a coastal bay, which will be useful for understanding the anthropogenic influence on the ecosystem structure and function.

Amelioration of Flesh Quality in Hybrid Grouper (♀ Epinephelus fuscoguttatus × ♂ E. lanceolatu) Fed With Oxidized Fish Oil Diet by Supplying Lactobacillus pentosus - Xiaobo Yan; Simiao Pan; Zhihao Li; Xiaohui Dong; Beiping Tan; Shuisheng Long; Tao Li; Xiangxiang Suo; Yuanzhi Yang (Frontiers in Marine Science, 2022)
The objective was to investigate the improvement of the flesh quality and nutritional value of hybrid grouper (♀ Epinephelus fuscoguttatus × ♂ E. lanceolatu ) by Lactobacillus pentosus (BL-15). The two diets were prepared with 9% oxidized fish oil (OFO negative control group) or 9% fresh fish oil (FFO positive control group) as the major lipid source, and the OFO diet were sprayed with L. pentosus at 1.0×10 7 , 1.0×10 8 , 1.0×10 9 CFU/g, respectively. Five kinds of diets were fed to hybrid grouper with initial weight of 21.36 ± 0.03 g for 60 days. The results showed that (1) consumption of OFO diet significantly increased muscle crude lipid, total cholesterol, and total monounsaturated fatty acids contents and significantly decreased muscle C20:5n3, C22:6n3, ∑PUFA levels of grouper ( p < 0.05), whereas the addition of L. pentosus to OFO diet significantly reduced muscle crude lipid, malondialdehyde, reactive oxygen radicals, total cholesterol concentration, increased C20:5n3, C22:6n3, ∑PUFA levels, increased muscle crude protein content, and enhanced muscle hardness, gumminess, and chewiness compared with FFO or OFO group ( p < 0.05). (2) In addition, ingestion of OFO diet significantly increased muscle phenylalanine content and significantly decreased aspartic acid content ( p < 0.05), while the addition of L. pentosus restored aspartic acid to the level not significantly different from that of FFO group ( p > 0.05). The addition of L. pentosus also increased tyrosine, lysine, leucine, phenylalanine, arginine, and alanine content compared to FFO group at the same time ( p < 0.05). (3) Furthermore, the intake of OFO diet would lead to deterioration in muscle flavor quality and increase in noxious odors in grouper, and the addition of L. pentosus can mitigate or rectify these detrimental consequences. In further analysis, consumption of OFO group significantly downregulated the mRNA expression of muscle growth factors and caused serious damage to the muscle antioxidant system ( p < 0.05), which was protected against by the potent antioxidant properties of L. pentosus . We recommend the supplementation level of L. pentosus to be 1.0×10 9 CFU/g under the highly oxidized conditions of the present trial fish oil.

The Differences in Structure and Function of the Cerebellum Between Cantonese-Mandarin Bilinguals and Mandarin Monolinguals: a Multi-model MRI Study - Yuying Jin; Xiaoxuan Fan; Xiaoyu Xu; Ning Pan; Jin Jing; Xiaojing Song; Si Tan; Xuning Guo; Xiuhong Li (The Cerebellum, 2022)

A stable block adjustment method without ground control points using bound constrained optimization - Yonghua Jiang; Zhen Li; Meilin Tan; Shaodong Wei; Guo Zhang; Zhichao Guan; Bin Han (International Journal of Remote Sensing, 2022)

Shoal-to-Strata Ratio Technique and Its Use in Describing Carbonate Rock Sedimentary Facies in the Eastern Sichuan Basin - Xiuquan Hu; Hong Liu; Xiucheng Tan; Chenjing Xiao; Qian Tan; Jianghan Li; Chi Yi (Journal of Marine Science and Engineering, 2022)
The requirements for the accurate characterization of shoal sediments have increased in view of the fact that strata are eroded due to uplift and it is difficult to calculate the real thickness of granular shoal. To solve this problem, with the shoal-to-strata ratio, the type and distribution range of carbonate rock shoal facies are described, and the characterization of sedimentary facies is subsequently presented. Taking the P2m2a in Eastern Sichuan as an example, the following conclusions were obtained. (1) The primary rock types of the shoal facies of the P2m2a are bioclastic limestone and micrite limestone. The logging facies of platform margin shoals, intra-platform high-energy shoals, intra-platform low-energy shoals, and sloping low-energy shoals are large funnel-type, small funnel-type, box-type, and finger-like, respectively. The platform margin shoals and intra-platform high-energy shoals are imbricate seismic facies, and the intra-platform low-energy shoals and sloping low-energy shoals are S-type progradation seismic facies and oblique progradation. (2) The shoal-to-strata ratio of platform margin shoals is the highest, followed by intra-platform high-energy shoals, intra-platform low-energy shoals, and sloping low-energy shoals. (3) Shoal facies deposits have a certain controlling effect on gas production, and platform margin shoals have greater exploration potential. (4) This example shows that in the areas where carbonate rock strata are eroded, compared with the method of characterizing the sedimentary facies of carbonate rock using the shoal thickness, the shoal-to-strata ratios are more accurate. (5) The planar distribution diagram of the shoal-to-strata ratio can be used as a supporting map for compiling sedimentary facies maps. This method is worth applying in related research fields.

Biotic Response to Rapid Environmental Changes During the Permian–Triassic Mass Extinction - Guoshan Li; Yongbiao Wang; Sheng Li; Tan Wang; Wei Liao; Baozhu Deng; Zhongping Lai (Frontiers in Marine Science, 2022)
The divergent patterns of Permian–Triassic mass extinction (PTME) have been extensively documented in varying water depth settings. We here investigated fossil assemblages and sedimentary microfacies on high-resolution samples from two adjacent sections of the South China Block: Chongyang from shallow-water platform and Chibi from deeper-water slop. At Chongyang, abundant benthos (over 80%), including rugose corals, fusulinids, calcareous algae, and large foraminifers, disappeared precipitously at the topmost of Changxing Formation grainstone, which suggested complete damage of the benthic ecosystem, confirming a sudden single-pulse extinction pattern. The end-Permian regression, marked by a karst surface, provided a plausible explanation for this extinction pattern. Whereas for the fauna in Chibi, the benthos was relatively abundant (20%–55%) with more trace fossils and lacking calcareous algae. Benthic abundance in Chibi reduced by two steps at the two claystone beds (Beds 10 and 18): bioclastic content dropped from an average of 50% in Beds 1–9 to 10% in Beds 11–17 and then to less than 5% in Beds 19–23, suggesting a two-pulse extinction. At the first pulse, large foraminifers were prominent victims in both shallow- and deeper-water settings. A plausible survival strategy for small-sized foraminifers was to migrate to deeper water to avoid extreme heat in shallow water. The early Triassic transgression prompted some small foraminifers to migrate back to original platforms and flourish briefly as disaster forms. At the Early Triassic mudstone with bottom-water settings in Chibi, the appearance of abundant small pyrite framboids (diameters of 4.74–5.96 μm), an indicator of intensified oxygen deficiency, was simultaneous with the two-step reduction of benthic diversity and abundance. Thus, anoxic conditions might be the main cause of the PTME at deeper-water settings. Our study is an example of the wider debate about biotic response to rapid environmental change for both the Permian–Triassic transition and modern days.

Fourier Coefficients Variation with Angle for Fracture Detection and Fluid Discrimination in Tilted Transversely Isotropic Media - Zhengqian Ma; Xingyao Yin; Kun Li; Yuanyuan Tan (Surveys in Geophysics, 2022)

Bmal1- and Per2-mediated regulation of the osteogenic differentiation and proliferation of mouse bone marrow mesenchymal stem cells by modulating the Wnt/β-catenin pathway - Jiawen Zheng; Lanxin Zhang; Zhen Tan; Qing Zhao; Xiaoyu Wei; Yuqing Yang; Rong Li (Molecular Biology Reports, 2022)

Extracellular vesicles derived from human Sertoli cells: characterizations, proteomic analysis, and miRNA profiling - Xiao-Hui Tan; Sheng-Ji Gu; Wen-Jie Tian; Wen-Peng Song; Yang-Yang Gu; Yi-Ming Yuan; Xue-Song Li; Zhong-Cheng Xin; Sae Woong Kim; Rui-Li Guan; Woong Jin Bae (Molecular Biology Reports, 2022)

Ligustilide ameliorates cognitive impairment via AMPK/SIRT1 pathway in vascular dementia rat - Dong Peng; Han-Zi Qiao; Hong-Yu Tan; Yi-Xue Wang; Dan Luo; Li-Jun Qiao; Ye-Feng Cai; Shi-Jie Zhang; Qi Wang; Li Guan (Metabolic Brain Disease, 2022)

Dynamic changes of reactive oxygen species in paddy overlying water: mechanisms and implications - Shaochong Liu; Mengxi Tan; Danyu Huang; Dixiang Wang; Mengyuan Geng; Jialin Wen; Changyin Zhu; Liqiang Ge; Ning Chen; Yan Gao; Jiangye Li; Jianbin Pan; et al. (Journal of Soils and Sediments, 2022)

Visualizing the Spatiotemporal Characteristics of Dockless Bike Sharing Usage in Shenzhen, China - Feng Gao; Shaoying Li; Zhangzhi Tan; Shunyi Liao (Journal of Geovisualization and Spatial Analysis, 2022)

Prediction of disability-free survival in healthy older people - Johannes Tobias Neumann; Le T. P. Thao; Anne M. Murray; Emily Callander; Prudence R. Carr; Mark R. Nelson; Rory Wolfe; Robyn L. Woods; Christopher M. Reid; Raj C. Shah; Anne B. Newman; Jeff D. Williamson; et al. (GeroScience, 2022)
Prolonging survival in good health is a fundamental societal goal. However, the leading determinants of disability-free survival in healthy older people have not been well established. Data from ASPREE, a bi-national placebo-controlled trial of aspirin with 4.7 years median follow-up, was analysed. At enrolment, participants were healthy and without prior cardiovascular events, dementia or persistent physical disability. Disability-free survival outcome was defined as absence of dementia, persistent disability or death. Selection of potential predictors from amongst 25 biomedical, psychosocial and lifestyle variables including recognized geriatric risk factors, utilizing a machine-learning approach. Separate models were developed for men and women. The selected predictors were evaluated in a multivariable Cox proportional hazards model and validated internally by bootstrapping. We included 19,114 Australian and US participants aged ≥65 years (median 74 years, IQR 71.6–77.7). Common predictors of a worse prognosis in both sexes included higher age, lower Modified Mini-Mental State Examination score, lower gait speed, lower grip strength and abnormal (low or elevated) body mass index. Additional risk factors for men included current smoking, and abnormal eGFR. In women, diabetes and depression were additional predictors. The biased-corrected areas under the receiver operating characteristic curves for the final prognostic models at 5 years were 0.72 for men and 0.75 for women. Final models showed good calibration between the observed and predicted risks. We developed a prediction model in which age, cognitive function and gait speed were the strongest predictors of disability-free survival in healthy older people. Trial registration Clinicaltrials.gov (NCT01038583)

Localization of salt-tolerant QTL in rice germination stage under different salinity concentrations - Yanning Wang; Liping Chen; Guiting Song; Tao Huang; Guangliang Wu; Jingai Tan; Peng Wang; Qin Cheng; Caijing Li; Qi Zhong; Shiying Huang; Mengmeng Yang; et al. (Euphytica, 2022)

An endeavor of “deep-underground agriculture”: storage in a gold mine impacts the germination of canola (Brassica napus L.) seeds - Yang Wang; Yuxin He; Jingchen Wang; Chao Liu; Longguo Li; Xiao Tan; Bo Tan (Environmental Science and Pollution Research, 2022)

Unveiling characteristics and trend of zero waste research: a scientometric perspective - Shang Zhang; Quanyin Tan; Guochang Xu; Jinhui Li (Environmental Science and Pollution Research, 2022)

Short-term air quality forecasting model based on hybrid RF-IACA-BPNN algorithm - De-wen Qiao; Jian Yao; Ji-wen Zhang; Xin-long Li; Tan Mi; Wen Zeng (Environmental Science and Pollution Research, 2022)

Both specific plant functional type loss and vegetation change influence litter metallic element release in an alpine treeline ecotone - Yu Zhou; Xian Shen; Yamei Chen; Lifeng Wang; Jian Zhang; Zhenfeng Xu; Li Guo; Bo Tan; Lixia Wang; Chengming You; Yang Liu (Environmental Science and Pollution Research, 2022)

Rapid triage for ischemic stroke: a machine learning-driven approach in the context of predictive, preventive and personalised medicine - Yulu Zheng; Zheng Guo; Yanbo Zhang; Jianjing Shang; Leilei Yu; Ping Fu; Yizhi Liu; Xingang Li; Hao Wang; Ling Ren; Wei Zhang; Haifeng Hou; et al. (EPMA Journal, 2022)
Background Recognising the early signs of ischemic stroke (IS) in emergency settings has been challenging. Machine learning (ML), a robust tool for predictive, preventive and personalised medicine (PPPM/3PM), presents a possible solution for this issue and produces accurate predictions for real-time data processing. Methods This investigation evaluated 4999 IS patients among a total of 10,476 adults included in the initial dataset, and 1076 IS subjects among 3935 participants in the external validation dataset. Six ML-based models for the prediction of IS were trained on the initial dataset of 10,476 participants (split participants into a training set [80%] and an internal validation set [20%]). Selected clinical laboratory features routinely assessed at admission were used to inform the models. Model performance was mainly evaluated by the area under the receiver operating characteristic (AUC) curve. Additional techniques—permutation feature importance (PFI), local interpretable model-agnostic explanations (LIME), and SHapley Additive exPlanations (SHAP)—were applied for explaining the black-box ML models. Results Fifteen routine haematological and biochemical features were selected to establish ML-based models for the prediction of IS. The XGBoost-based model achieved the highest predictive performance, reaching AUCs of 0.91 (0.90–0.92) and 0.92 (0.91–0.93) in the internal and external datasets respectively. PFI globally revealed that demographic feature age, routine haematological parameters, haemoglobin and neutrophil count, and biochemical analytes total protein and high-density lipoprotein cholesterol were more influential on the model’s prediction. LIME and SHAP showed similar local feature attribution explanations. Conclusion In the context of PPPM/3PM, we used the selected predictors obtained from the results of common blood tests to develop and validate ML-based models for the diagnosis of IS. The XGBoost-based model offers the most accurate prediction. By incorporating the individualised patient profile, this prediction tool is simple and quick to administer. This is promising to support subjective decision making in resource-limited settings or primary care, thereby shortening the time window for the treatment, and improving outcomes after IS.

Characterization and Functional Explorations of O-glycosylation Enzymes SECRET AGENT and SPINDLY in Pyrus bretschneideri - Hongru Gao; Qiuping Tan; Qionghou Li; Guodong Chen; Chao Tang; Peng Cao; Ming Qian; Mingliang Zhang; Peng Wang; Shaoling Zhang; Juyou Wu (Journal of Plant Biology, 2022)

Indiscriminate Dietary Compositions of Two Asian Horseshoe Crabs, Tachypleus tridentatus and Carcinoscorpius rotundicauda: Evidence from Hemolymph Stable Isotopes - Yuhong Li; Jianxiang Feng; Kit Yue Kwan; Yiran Tan; Bosen Weng; Ruiling Jia (Journal of Ocean University of China, 2022)

Risk assessment and cause analysis of water inrush in thin bedrock areas with shallow coal seams for safe, water-conserving mining - Jing Geng; Liqiong Zheng; Fei Tan; Daolei Xie; Jianguo Xu; Yunjiang Li; Yin Shi (Arabian Journal of Geosciences, 2022)

Comparison of different inversion methods of D-T2 two-dimensional nuclear magnetic resonance logging and applicability analysis - Cheng-Lin Li; Mao-Jin Tan; Ke-Wen Wang; Feng Zhou; Ying-Ming Liu; Hai-Tao Zhang; Li-Zhi Xiao (Applied Geophysics, 2022)

The Sm gene conferring resistance to gray leaf spot disease encodes an NBS-LRR (nucleotide-binding site-leucine-rich repeat) plant resistance protein in tomato - Huanhuan Yang; Hexuan Wang; Jingbin Jiang; Mingyue Liu; Zengbing Liu; Yinxiao Tan; Tingting Zhao; He Zhang; Xiuling Chen; Jingfu Li; Aoxue Wang; Minmin Du; et al. (Theoretical and Applied Genetics, 2022)

Increase in rosmarinic acid accumulation and transcriptional responses of synthetic genes in hairy root cultures of Prunella vulgaris induced by methyl jasmonate - Mei Ru; Yonghua Li; Min Guo; Liuyan Chen; Yong Tan; Liang Peng; Zongsuo Liang (Plant Cell, Tissue and Organ Culture (PCTOC), 2022)

Multiple indeterminate domain (IDD)–DELLA1 complexes participate in gibberellin feedback regulation in peach - Yajun Jiang; Jiajia Chen; Xianbo Zheng; Bin Tan; Xia Ye; Wei Wang; Langlang Zhang; Jidong Li; Zhiqian Li; Jun Cheng; Jiancan Feng (Plant Molecular Biology, 2022)

Quercetin Alleviates Demyelination Through Regulating Microglial Phenotype Transformation to Mitigate Neuropsychiatric Symptoms in Mice with Vascular Dementia - Zihu Tan; Guang Yang; Jing Qiu; Wenjing Yan; Yu Liu; Zhengling Ma; Jia Li; Jing Liu; Nan Shan (Molecular Neurobiology, 2022)

Hyperlipidemia patients carrying LDLR splicing mutation c.1187-2A>G respond favorably to rosuvastatin and PCSK9 inhibitor evolocumab - Xiaoyu Zhang; Qianqian Liu; Hongfu Zhang; Chengcheng Tan; Qiangfeng Zhu; Saiyong Chen; Yinglong Du; Haitao Yang; Qingli Li; Chengqi Xu; Chun Wu; Qing K. Wang (Molecular Genetics and Genomics, 2022)

Damage Analysis of Chemically Corroded Sandstone Under Cyclic Impacts and Axial Static Pressure - Zhuyu Zhao; Jinchun Xue; Jiefang Jin; Li Tan; Ruoyan Cai; Wenbin Xia (Geotechnical and Geological Engineering, 2022)

Heavy metal characteristics in porewater profiles, their benthic fluxes, and toxicity in cascade reservoirs of the Lancang River, China - Zhenjie Zhao; Shehong Li; Shilu Wang; Jie Liao; Weiqi Lu; Di Tan; Dan Yang (Environmental Science and Pollution Research, 2022)

Interactive Effects of Cd and Pb on the Photosynthesis Efficiency and Antioxidant Defense System of Capsicum annuum L - Meng Kou; Juan Xiong; Ming Li; Mingxia Wang; Wenfeng Tan (Bulletin of Environmental Contamination and Toxicology, 2022)

Failure prediction from crack evolution and acoustic emission characteristics of coal-rock sandwich composite samples under uniaxial compression - Yunliang Tan; Qing Ma; Xuesheng Liu; Zenghui Zhao; Mingxin Zhao; Liang Li (Bulletin of Engineering Geology and the Environment, 2022)

Phenolic glycosides from Sanguisorba officinalis and their anti-inflammatory effects - Jin-feng Chen; Lu Tan; Feng Ju; Qi-xuan Kuang; Tian-long Yang; Fang Deng; Yu-cheng Gu; Li-shi Jiang; Yun Deng; Da-le Guo (Natural Product Research, 2022)

Bile Acids Reduced the Lipid Deposition in Fatty Degenerated Hepatocytes of Pearl Gentian Grouper (Epinephelus fuscoguttatus♂ × Epinephelus lanceolatus♀) in vitro - Jia Xu; Xinzhou Yao; Xiaoyue Li; Shiwei Xie; Shuyan Chi; Shuang Zhang; Junming Cao; Beiping Tan (Frontiers in Marine Science, 2022)
Little is known about the association of bile acids (BAs) with lipid deposition and lipid metabolism of fish in vitro . In the present study, we established the model of fatty-degenerated hepatocytes in pearl gentian grouper ( Epinephelus fuscoguttatus ♂ × Epinephelus lanceolatus ♀), and explored the effects and mechanism of BAs regulating on lipid metabolism in this model. The results showed that fatty-degenerated hepatocytes induced by lipid emulsion accumulated the intracellular triglyceride (TG), the enhanced expression of sterol responsive element binding protein 1 (SREBP1) protein, and the repressed expression of peroxisome proliferator-activated receptor alpha (PPARA), and phosphorylated PPARA (P-PPARA) proteins. BAs co-incubation reduced the content of TG, while increasing the expression of PPARA, farnesoid X receptor (FXR), and G protein-coupled bile acid receptor 1 (TGR5) proteins. Activation of FXR by INT-747 reduced the content of TG, while down-regulating the expression of SREBP1 and PPARA, and up-regulating the expression of P-PPARA, FXR, small heterodimer partner (SHP), and TGR5. Inhibition of FXR by guggulsterone increased the level of TG, while decreasing the expression of TGR5, increasing the expression of SHP. Activation of TGR5 by INT-777 reduced the content of TG, while down-regulating the expression of SREBP1 and SHP, up-regulated the expression of TGR5. Inhibition of TGR5 by SBI-115 elevated the level of TG, while reducing the expression of P-PPARA and TGR5. In conclusion, the FXR and/or TGR5 signaling pathways which were inhibited in fatty-degenerated hepatocytes from pearl gentian grouper, were activated after BAs co-incubation, then altering the lipid metabolism by repressing lipogenesis and enhancing lipolysis, and regulating transcriptional factors, thus reduces the lipid accumulation in vitro .

Trichocladabiflavone A, a chalcone-flavonone type biflavonoid from Selaginella trichoclada Alsto - Yang Xie; Xiao-Chang Yao; Lei-Hong Tan; Hong-Ping Long; Ping-Sheng Xu; Jing Li; Gui-Shan Tan (Natural Product Research, 2022)

Identification and validation of quantitative trait loci for the functional stay green trait in common wheat (Triticum aestivum L.) via high-density SNP-based genotyping - Tianheng Ren; Tao Fan; Shulin Chen; Yongyan Chen; Xia Ou; Qing Jiang; Wanhua Peng; Zhenglong Ren; Feiquan Tan; Peigao Luo; Zhi Li (Theoretical and Applied Genetics, 2022)

Industrialization progress of lignocellulosic ethanol - Liangliang Wang; Muhammad Bilal; Congping Tan; Xirui Jiang; Fangfang Li (Systems Microbiology and Biomanufacturing, 2022)

Effects of mowing frequency on abundance, genus diversity and community traits of soil nematodes in a meadow steppe in northeast China - F. J. Pan; L. Y. Yang; C. L. Wang; R. R. Yan; C. J. Li; Y. F. Hu; Y. Jiang; J. Cao; H. Y. Tan; X. P. Xin (Plant and Soil, 2022)

The Macrophage IL-23/IL-17A Pathway: A New Neuro-Immune Mechanism in Female Mechanical Pain - Zhi Tan; Zhen-Jia Lin; Long-Jun Wu; Li-Jun Zhou (Neuroscience Bulletin, 2022)

Follicular Fluid-Derived Exosomal MicroRNA-18b-5p Regulates PTEN-Mediated PI3K/Akt/mTOR Signaling Pathway to Inhibit Polycystic Ovary Syndrome Development - Zhi Zhou; Zhihua Tu; Juan Zhang; Can tan; Xiaoyong Shen; Bangbei Wan; Yejuan Li; Anguo Wang; Liqiang Zhao; Jiajia Hu; Ning Ma; Jing Zhou; et al. (Molecular Neurobiology, 2022)

Correction to: Downregulation of fibronectin 1 attenuates ATRA‑induced inhibition of cell migration and invasion in neuroblastoma cells - Xiaolin Tan; Wei Gong; Bo Chen; Baocheng Gong; Zhongyan Hua; Simeng Zhang; Yang Chen; Qi Li; Zhijie Li (Molecular and Cellular Biochemistry, 2022)

Geochemistry of rhodonite in the Luziyuan Pb − Zn skarn deposit, Southwestern China - Yulong Yang; Lin Ye; Wei Gao; Tan Bao; Zhenli Li; Yusi Hu; Chen Wei (Mineralogy and Petrology, 2022)

Comparative metabolomics provides novel insights into the basis of petiole color differences in celery (Apium graveolens L.) - Mengyao Li; Jie Li; Haohan Tan; Ya Luo; Yong Zhang; Qing Chen; Yan Wang; Yuanxiu Lin; Yunting Zhang; Xiaorong Wang; Haoru Tang (Journal of Zhejiang University-SCIENCE B, 2022)

A genetic-based population PK/PD modeling of methadone in Chinese opiate dependence patients - Dong Guo; Zhirong Tan; Xiaoya Lou; Shan Shi; Yan Shu; Honghao Zhou; Li Yu; Hong Yang (European Journal of Clinical Pharmacology, 2022)

Morphologic changes of simple star dunes during the growth process in Dunhuang, China - Zhi-shan An; Ke-cun Zhang; Li-hai Tan; Qing-he Niu; Ben-li Liu; Bai-cheng Niu (Journal of Mountain Science, 2022)

Numerical simulation of fracture failure characteristics of rock mass with multiple parallel fractures under seepage stress coupling - Peng-fei Wang; Chang-hong Li; Wen-hui Tan (Arabian Journal of Geosciences, 2022)

Preparation and In Vitro and In Vivo Evaluation of a Testosterone Film Forming Gel for the Treatment of Hypoactive Sexual Desire Disorder in Women - Jia Zeng; Tan-Fang Xie; Ting Huang; Fang Li; Zhi-Ping Wang; Ling-Lin Feng (AAPS PharmSciTech, 2022)

Microplastic Contamination on the Beaches of South China - Bingwen Chai; Yanping Li; Li Wang; Xiao-Tan Zhang; Yi-Ping Wan; Fengyuan Chen; Jie Ma; Wenlu Lan; Ke Pan (Frontiers in Marine Science, 2022)
Microplastics (MPs) have emerged as a pollutant of significant global concern. The sandy beach is a fragile environment that deserves our special attention with regard to MP contamination, as this area is a hotspot that accumulates large quantities of plastic waste. Notably, our current understanding of the MP distribution on beaches and the scale of contamination is far from sufficient. Hence, this study investigated the occurrence and characteristics of MPs on 14 beaches along the coast of South China. The MPs were ubiquitously distributed in the sand, most were small, less than 1 mm. A total of 18 types of polymers were identified in the sand, suggesting that diverse types of MPs are present on the beaches. Polyethylene, polypropylene, and polystyrene were the dominant types of MPs in most of our sampling sites. The MP abundance was higher in the upper layers (0–20 cm) of the beach than in the deeper layers (20–40 cm) of the sampling site when characterized by depth (Yangjiang beach). Our study demonstrates the extent and severity of MP pollution on the beaches of South China and provides implications for future remediation measures. More effort is needed to clarify the vertical distribution of MPs on beaches, especially for those MPs less than 1 μm.

Alkaloids constituents from the roots of Phragmites australis (Cav.) Trin. ex Steud. with their cytotoxic activities - Ying Chen; Li Li; Li-Rui Jiang; Jia-Yin Tan; Li-Na Guo; Xiao-Li Wang; Wei Dong; Wen-Bao Wang; Ji-Kai Sun; Bo Song (Natural Product Research, 2022)

Effects of Lower Fishmeal With Hydrolyzed Fish Protein Powder on the Growth Performance and Intestinal Development of Juvenile Pearl Gentian Grouper (Epinephelus fuscoguttatus ♀ and Epinephelus lanceolatus ♂) - Vivian Hlordzi; Junqing Wang; Tianbi Li; Zhiying Cui; Beiping Tan; Hongyu Liu; Qihui Yang; Xiaohui Dong; Shuang Zhang; Shuyan Chi (Frontiers in Marine Science, 2022)
The effect of hydrolyzed fish protein powder (HFP) on the growth, intestinal development, gene mRNA expression, and enzyme activity in the intestine and liver of juvenile hybrid grouper ( Epinephelus fuscoguttatus ♀ and Epinephelus lanceolatus ♂) was assessed after an 8-week feeding trial. Seven isonitrogenous (50%) and isolipidic (9%) diets were fed to hybrid grouper with 0% (CT), 1% (H1), 1.5% (H2), 2% (H3), 2.5% (H4), 3% (H5), and 4% (H6) HFP. No significant difference ( p > 0.05) in weight gain rate (WGR), specific growth rate (SGR), feed conversion ratio (FCR), and survival rate (SR) was observed in all the groups. The crude protein content in the H6 group was significantly higher than in the other groups ( p < 0.05). Intestinal lipase and trypsin activity were significantly higher in H3 and H5 groups ( p < 0.05). In the serum, superoxide dismutase (SOD) activity was significantly higher in H5 and H6 groups, while malondialdehyde (MDA) activity was lower ( p < 0.05) compared to other treatments. Insulin-like growth factor ( IGF-I ) and target of rapamycin ( TOR ) mRNA expression levels in the intestine and muscle were significantly higher in the H2 group and H1 group ( p < 0.05), respectively. The most abundant intestinal bacteria found at the genus level are Acinetobacter , Vibrio , and Flavobacteriaceae. The villus was significantly longer in hybrid grouper fed with different levels of HFP compared to the control, and fish in the H2 group had thicker intestinal muscle compared to the other groups ( p < 0.05). In conclusion, the addition of HFP to the low fishmeal (FM) diets of juvenile grouper improved the intestinal development and increased the levels of intestinal digestive enzymes.

Characterization of the temperature and oxygen concentration field in a decentralized solid-waste incinerator for villages and towns - Dongsheng Shen; Wenxiang Li; Foqin Sun; Shengqi Qi; Hao Tan; Chen Chen; Yuyang Long (Waste Disposal & Sustainable Energy, 2022)

Aldosterone dysregulation predicts the risk of mortality and rehospitalization in heart failure with a preserved ejection fraction - Bingbing Ke; Xin Tan; Lu Ren; Yangkai Fan; Yixin Zhang; Fengjuan Li; Qiqi Sun; Tong Liu; Lixin Jia; Yuan Wang; Jie Du (Science China Life Sciences, 2022)

Long Non-coding Antisense RNA DDIT4-AS1 Regulates Meningitic Escherichia coli-Induced Neuroinflammation by Promoting DDIT4 mRNA Stability - Bo Yang; Bojie Xu; Ruicheng Yang; Jiyang Fu; Liang Li; Dong Huo; Jiaqi Chen; Xiaopei Yang; Chen Tan; Huanchun Chen; Xiangru Wang (Molecular Neurobiology, 2022)
Our previous studies have shown that meningitic Escherichia coli can colonize the brain and cause neuroinflammation. Controlling the balance of inflammatory responses in the host central nervous system is particularly vital. Emerging evidence has shown the important regulatory roles of long non-coding RNAs (lncRNAs) in a wide range of biological and pathological processes. However, whether lncRNAs participate in the regulation of meningitic E. coli -mediated neuroinflammation remains unknown. In the present study, we characterized a cytoplasm-enriched antisense lncRNA DDIT4-AS1 , which showed similar concordant expression patterns with its parental mRNA DDIT4 upon E. coli infection. DDIT4-AS1 modulated DDIT4 expression at both mRNA and protein levels. Mechanistically, DDIT4-AS1 promoted the stability of DDIT4 mRNA through RNA duplex formation. DDIT4-AS1 knockdown and DDIT4 knockout both attenuated E. coli -induced NF-κB signaling as well as pro-inflammatory cytokines expression, and DDIT4-AS1 regulated the inflammatory response by targeting DDIT4 . In summary, our results show that DDIT4-AS1 promotes E. coli -induced neuroinflammatory responses by enhancing the stability of DDIT4 mRNA through RNA duplex formation, providing potential nucleic acid targets for new therapeutic interventions in the treatment of bacterial meningitis.

Genome-wide identification and expression of the lipoxygenase gene family in jujube (Ziziphus jujuba) in response to phytoplasma infection - Jidong Li; Lichuan Chen; Peng Chen; Qicheng Li; Qiqi Yang; Yu Zhang; Bin Tan; Xia Ye; Xianbo Zheng; Jiancan Feng (Journal of Plant Biochemistry and Biotechnology, 2022)

Nanocarrier-mediated transdermal dsRNA-NPF1 delivery system contributes to pest control via inhibiting feeding behavior in Grapholita molesta - Hongshuang Wei; Shuqian Tan; Shuo Yan; Zhen Li; Jie Shen; Xiaoxia Liu (Journal of Pest Science, 2022)

Study on Progressive Instability Characteristics of Coal-Rock Composite Structure with the Different Height Ratios - Tan Li; Guangbo Chen; Yanhui Li; Qinghai Li (Geotechnical and Geological Engineering, 2022)

Characteristics of Collapse Accumulation Body in Roadway and Numerical Simulation of Rescue Channel Excavation - Guangbo Chen; Pengcheng Teng; Huiqiang Duan; Guohua Zhang; Tan Li (Geotechnical and Geological Engineering, 2022)

Extraction of temporal information from social media messages using the BERT model - Kai Ma; Yongjian Tan; Miao Tian; Xuejing Xie; Qinjun Qiu; Sanfeng Li; Xin Wang (Earth Science Informatics, 2022)

Genomic characterization of a new enamovirus infecting common bean - Ruo-bin Lu; Ping-xiu Lan; Ru-jing Kang; Guan-lin Tan; Xiao-jiao Chen; Ruhui Li; Fan Li (Archives of Virology, 2022)

Visco − elastic − plastic creep model based on Burgers and Bingham model and its verification - Jinpeng Zhao; Zhongsheng Tan; Lei Li; Rongsen Yu; Ke Lei (Arabian Journal of Geosciences, 2022)

Corrigendum: Pigmentibacter ruber gen. nov., sp. nov., a novel bacterium of the family Silvanigrellaceae isolated from human blood - Na Peng; Wen Xu; Hai-Min Luo; Peng-Wen Ouyang; Bin Jiang; Zhi-Hua Zhang; You-De Cao; Li-Ming Tan; Ping-Hua Qu; Liang-Yi Xie (Antonie van Leeuwenhoek, 2022)

Another Record: Ocean Warming Continues through 2021 despite La Niña Conditions - Lijing Cheng; John Abraham; Kevin E. Trenberth; John Fasullo; Tim Boyer; Michael E. Mann; Jiang Zhu; Fan Wang; Ricardo Locarnini; Yuanlong Li; Bin Zhang; Zhetao Tan; et al. (Advances in Atmospheric Sciences, 2022)
The increased concentration of greenhouse gases in the atmosphere from human activities traps heat within the climate system and increases ocean heat content (OHC). Here, we provide the first analysis of recent OHC changes through 2021 from two international groups. The world ocean, in 2021, was the hottest ever recorded by humans, and the 2021 annual OHC value is even higher than last year’s record value by 14 ± 11 ZJ (1 zetta J = 10 21 J) using the IAP/CAS dataset and by 16 ± 10 ZJ using NCEI/NOAA dataset. The long-term ocean warming is larger in the Atlantic and Southern Oceans than in other regions and is mainly attributed, via climate model simulations, to an increase in anthropogenic greenhouse gas concentrations. The year-to-year variation of OHC is primarily tied to the El Niño-Southern Oscillation (ENSO). In the seven maritime domains of the Indian, Tropical Atlantic, North Atlantic, Northwest Pacific, North Pacific, Southern oceans, and the Mediterranean Sea, robust warming is observed but with distinct inter-annual to decadal variability. Four out of seven domains showed record-high heat content in 2021. The anomalous global and regional ocean warming established in this study should be incorporated into climate risk assessments, adaptation, and mitigation.

Growth and Microstructural Features in Otoliths of Larval and Juvenile Sinogastromyzon wui (F. Balitoridae, River Loaches) of the Upper Pearl River, China - Minghui Gao; Zhiqiang Wu; Liangliang Huang; Xichang Tan; Mingsi Li; Haibo Huang (Fishes, 2022)
Otolith growth and microstructural features of fish are essential to the understanding of the early fish lifecycle. This paper assesses the features of otoliths from laboratory-reared larval and juvenile Sinogastromyzon wui (S. wui, 0 to 25 days post-hatching) that were obtained as eggs from the Shilong Reach of Xijiang River between April and August 2021. We observed the development of the three pairs of otoliths (lapilli, sagittae, and asterisci) and compared the shape changes and growth of the lapilli and sagittae, as well as the timing and deposition rate of increments of the lapilli. The lapilli and the sagittae were visible on hatching, whereas the asterisci were present at four days post-hatching (dph). The shape of the sagitta changed more obviously than that of the lapillus, and a strong correlation was observed between sagitta shape changes and fish ontogenesis. The otolith shape greatly modulated during the post-flexion larval stage (Post-FLS), it corresponded with the formation period of individual fins. Analysis of the microstructural features indicated that lapilli were the optimal otolith for age determination and increment deposition rate confirmation. Using regression analysis of the known age and the number of lapillus daily increments, we demonstrated that the lapillus developmental increments were deposited daily, and the first increment formed at two days post-hatching. Our conclusions support employing the lapillus increment deposition rate and the time of the first daily increments in the determination of the age of wild larval and juvenile S. wui.

A Challenge to Conventional Fish Meal: Effects of Soy Protein Peptides on Growth, Histomorphology, Lipid Metabolism and Intestinal Health for Juvenile Pompano Trachinotus ovatus - Huaxing Lin; Beiping Tan; Gyan Watson Ray; Min Zeng; Mei Li; Shuyan Chi; Qihui Yang (Frontiers in Marine Science, 2022)
This experiment was conducted to assess the possibility of replacing fish meal (FM) with soy protein peptide (SPP) at different levels—0% (FM), 14.29% (S5), 28.57% (S10), 57.14% (S20), 71.42%(S25)—and its effects on growth, histology, gene expression related to liver lipid metabolism and intestinal immunity in juvenile pompano Trachinotus ovatus (initial mean weight = 39.88 ± 0.15 g). 600 healthy and uniformed-size fish were distributed to five groups of three replicates, each with 40 fish in each floating cage and fed twice daily for 8 weeks. Results showed that no significant difference in the growth was observed with SPP replacing FM ( P > 0.05). Serum glutathione peroxidase activity in the S10 group was significantly higher than that in the FM group, and serum malondialdehyde content significantly decreased ( P < 0.05). SPP significantly improved intestinal immunity by increasing alkaline phosphatase and lysozyme activities and up-regulating interleukin 10 and complement 4 mRNA levels while simultaneously decreasing triglyceride and total cholesterol content and down-regulating interleukin 1β mRNA expression. Villus length and muscle thickness in the S10 group were significantly higher than those in the FM group ( P < 0.05). SPP significantly improved liver fat metabolism by increasing carnitine palmitoyl transferase I mRNA levels, and down-regulating fatty acid synthesis mRNA expression ( P < 0.05). In summary, SPP substitution for FM promoted intestinal health, liver lipid metabolism and reduced liver fat accumulation for juvenile pompano T. ovatus , with no significant effect on growth performance. Based on the second-order polynomial analysis model of LYZ activity, the optimal replacement SPP level for juvenile pompano T. ovatus was 11.82%.

A novel inverse transformation algorithm for pushbroom TDI CCD imaging - Yonghua Jiang; Guo Zhang; Litao Li; Ziqiang Tan; Zhongxing Tang; Yi Xu (International Journal of Remote Sensing, 2022)

Superiority of Adipose-derived CD34 + Cells over Adipose-derived Stem Cells in Promoting Ischemic Tissue Survival - Yan-Jun Liu; Tian-Yu Zhang; Poh-Ching Tan; Pei-Qi Zhang; Yun Xie; Qing-Feng Li; Shuang-Bai Zhou (Stem Cell Reviews and Reports, 2022)

Allelically and Differentially Expressed Genes After Infection of Edwardsiella ictaluri in Channel Catfish as Determined by Bulk Segregant RNA-Seq - Yulin Jin; Tao Zhou; Wansheng Jiang; Ning Li; Xiaoyan Xu; Suxu Tan; Huitong Shi; Yujia Yang; Zihao Yuan; Wenwen Wang; Guyu Qin; Shikai Liu; et al. (Marine Biotechnology, 2022)

Analysis the Characteristic of Energy and Damage of Coal-Rock Composite Structure Under Cycle Loading - Tan Li; Guangbo Chen; Zhongcheng Qin; Qinghai Li (Geotechnical and Geological Engineering, 2022)

Fixed-bed column dynamics of ultrasound and Na-functionalized diatomite to remove phosphate from water - Junxiu Ye; Min Yang; Xuemei Ding; Wei Tan; Guizhen Li; Shuju Fang; Hongbin Wang (Environmental Science and Pollution Research, 2022)

Yohimbine Directly Induces Cardiotoxicity on Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes - Yiqi Gong; Li Yang; Jun Tang; Jijian Zheng; Nevin Witman; Philipp Jakob; Yao Tan; Minglu Liu; Ying Chen; Huijing Wang; Wei Fu; Wei Wang (Cardiovascular Toxicology, 2022)

Mechanism and effects of the increase in winter temperatures in the Arctic region on cold winters in Heilongjiang Province, Northeast China for the period 1961–2018 - Xiaodi Wang; Yongsheng Li; Lijuan Zhang; Shuaifeng Song; Tao Pan; Chong Ren; Yulong Tan (Journal of Geographical Sciences, 2022)

Biotic elicitation at different feeding time in cell suspension cultures of Eurycoma longifolia Jack, a valuable medicinal plant, for enhancement of cytotoxic activity of bioactive compounds against human colon cancer cell line - Li See Kwan; Shu Ying Tan; Yoshiyuki Hirata; Lai-Keng Chan; Yasuo Nagaoka; Shinichi Uesato; Peng Lim Boey (In Vitro Cellular & Developmental Biology - Plant, 2022)

Sequential stress control and delayed support in deep shaft construction - Huanxin Liu; Zhuoying Tan; Xi Wang; Xingquan Liu; Xingdong Zhao; Yangyang Li (Arabian Journal of Geosciences, 2022)
In constructing hard rock mine deep shafts, the failure caused by high stress is a significant problem. A construction section extending from the -930 m to -1271 m level of a 1527 m deep shaft was selected as a case study. Q, RMR, and GSI rock mass quality classifications of the surrounding rock were obtained to determine the shaft’s maximum unsupported sinking cycle height in different construction sections. The potential failure mode, failure zone shape, and failure depth of the surrounding rock shaft under high stress were then analyzed theoretically, empirically, and by numerical simulation, sequential stress control and delayed support technology was proposed according to the results. The temporary and permanent support timing parameters were calculated and verified by the empirical chart, numerical simulation, convergence-confinement theory, and theoretical formula. Results show that the surrounding rock in all the construction sections from -930 m to -1271 m belongs to the mild or severely pressure squeezed strata. The potential failure mode is stress-controlled, and the failure zone of the surrounding rock is “ear” shaped. Temporary support strengthens the rock mass, improves the shear capacity of surrounding rock, and prevents the broken rock from falling but does not release stress. Permanent support, conversely, cannot bear the stress of surrounding rock. The stress and elastic strain energy in rock mass should be released to the greatest extent possible before installing permanent support; it is not advisable to install it too early. The time and cycle height of delayed permanent shaft support were comprehensively determined to be four days and 16 m, respectively. The numerical simulation and safety factor proof show that the sequential stress control process effectively minimizes stress in surrounding rock and ensures long-term shaft stability.

Identifying the moisture source of atmospheric precipitation in a typical alpine river watershed using stable H–O isotopes and HYSPLIT model - Tianning Li; Wenbo Rao; Hongbing Tan; Yaowei Li; Tao Tan (Arabian Journal of Geosciences, 2022)

Integrative testing device for investigating the hydro-mechanical behavior of highly expansive clay - Yun-zhi Tan; Fan Peng; Hui Li; Hua-jun Ming; De-an Sun (Arabian Journal of Geosciences, 2022)

Swimming behaviour of silver carp ( Hypophthalmichthys molitrix ) in response to turbulent flow induced by a D ‐cylinder - Senfan Ke; Zhiying Tu; Elsa Goerig; Junjun Tan; Bixin Cheng; Zhimin Li; Xiaotao Shi (Journal of Fish Biology, 2022)
Turbulence is a complex hydraulic phenomenon which commonly occurs in natural streams and fishways. Riverine fish are subjected to heterogeneous flow velocities and turbulence, which may affect their movements and ability to pass the fishways. However, studies focusing on fish response to turbulent flows are lacking for many species. Here we investigate the effects of the turbulence created by a vertical half‐cylinder of various diameters (1.9, 2.5, 3.2 and 5.0 cm) on the swimming ability and behaviour of silver carp, Hypophthalmichthys molitrix . The large D‐cylinders (3.0 and 5.0 cm) create specific vorticity and reduced velocities areas in their vicinity, which favours flow refuging behaviours (FRBs) and thus increased relative critical swimming speeds ( U rcrit , BL/s) of silver carp, by comparison to free‐flow conditions and cylinders of smaller diameter (1.9 and 2.5 cm). The flow speed at which silver carp maximized FRBs such as Karman gaiting downstream of the cylinder, holding position in the bow wake or entraining on the side ranged from 40 to 70 cm s −1 , depending on fish body size. When holding station near a cylinder under optimal flow speeds, the distance between the fish and the cylinder is related to the size of the fish, but also to the size of the cylinder and the produced vortices. The optimal holding region in the drag wake of the cylinder ranged from 28 to 40 cm downstream of the centre of the cylinder, depending on the size of the fish. Smaller fish, however, tend to use the reduced velocities areas located in the bow wake of the large cylinders. We hypothesize that fish will display FRBs, including maintaining a Karman gait in turbulent flow, when the ratio of the cylinder diameter to their body length is between 1:3 and 1:4. They also match their tail beat frequency to the vortex shedding frequency of the cylinder. Our results provide a better understanding of how silver carp respond to turbulent flows around physical structures, with implications for the design of nature‐like fishways or exclusion devices in both its native and invasive ranges.

Development of Recombinant Dihydrolipoamide Dehydrogenase Subunit Vaccine against Vibrio Infection in Large Yellow Croaker - Xiaomeng Li; Yuanzhen Tan; Zheng Zhang; Yupeng Huang; Pengfei Mu; Zhengwei Cui; Xinhua Chen (Fishes, 2022)
Large yellow croaker (Larimichthys crocea), an economically important marine fish in China, has suffered from serious vibriosis, which has resulted in great economic losses for the large yellow croaker industry. Vaccination has been considered to be a safe and effective method to prevent and control vibriosis. However, due to the complex diversity and serotypes of the Vibrio genus, the progress of Vibrio vaccine development is still slow. In this study, we prepared recombinant Vibrio dihydrolipoamide dehydrogenase (rDLD) protein and investigated its potential as a candidate to be a subunit vaccine against Vibrio. The lysozyme activity and the rDLD-specific antibody level in sera of large yellow croakers immunized with rDLD were significantly higher than those in the control group, and the transcript levels of proinflammatory cytokines (IL-6, IL-8, IL-1β), MHC IIα/β, CD40, CD8α, IL-4/13A, and IL-4/13B were significantly up-regulated in the spleen and head kidney of large yellow croakers immunized with rDLD, suggesting that rDLD could induce both specific and nonspecific immune responses in this species. In addition, rDLD protein increased the survival rate of large yellow croakers against Vibrio alginolyticus and Vibrio parahaemolyticus, with the relative percent of survival (RPS) being 74.5% and 66.9%, respectively. These results will facilitate the development of a potential subunit vaccine against Vibrio in large yellow croaker aquaculture.

Seven new glycosides from the leaves of Datura metel L. - Jin-Yan Tan; Yan Liu; Yan-Gang Cheng; Yan-Ping Sun; Xiao-Mao Li; Wei Guan; Juan Pan; Bing-You Yang; Hai-Xue Kuang (Natural Product Research, 2022)