Prediction of disability-free survival in healthy older people - Johannes Tobias Neumann; Le T. P. Thao; Anne M. Murray; Emily Callander; Prudence R. Carr; Mark R. Nelson; Rory Wolfe; Robyn L. Woods; Christopher M. Reid; Raj C. Shah; Anne B. Newman; Jeff D. Williamson; et al. (GeroScience, 2022)
Prolonging survival in good health is a fundamental societal goal. However, the leading determinants of disability-free survival in healthy older people have not been well established. Data from ASPREE, a bi-national placebo-controlled trial of aspirin with 4.7 years median follow-up, was analysed. At enrolment, participants were healthy and without prior cardiovascular events, dementia or persistent physical disability. Disability-free survival outcome was defined as absence of dementia, persistent disability or death. Selection of potential predictors from amongst 25 biomedical, psychosocial and lifestyle variables including recognized geriatric risk factors, utilizing a machine-learning approach. Separate models were developed for men and women. The selected predictors were evaluated in a multivariable Cox proportional hazards model and validated internally by bootstrapping. We included 19,114 Australian and US participants aged ≥65 years (median 74 years, IQR 71.6–77.7). Common predictors of a worse prognosis in both sexes included higher age, lower Modified Mini-Mental State Examination score, lower gait speed, lower grip strength and abnormal (low or elevated) body mass index. Additional risk factors for men included current smoking, and abnormal eGFR. In women, diabetes and depression were additional predictors. The biased-corrected areas under the receiver operating characteristic curves for the final prognostic models at 5 years were 0.72 for men and 0.75 for women. Final models showed good calibration between the observed and predicted risks. We developed a prediction model in which age, cognitive function and gait speed were the strongest predictors of disability-free survival in healthy older people. Trial registration Clinicaltrials.gov (NCT01038583)

Organophosphate esters in children and adolescents in Liuzhou city, China: concentrations, exposure assessment, and predictors - Meng Yu; Xiang Li; Bingqing Liu; Yaping Li; Ling Liu; Limei Wang; Lulu Song; Youjie Wang; Liqin Hu; Surong Mei (Environmental Science and Pollution Research, 2022)

Rapid triage for ischemic stroke: a machine learning-driven approach in the context of predictive, preventive and personalised medicine - Yulu Zheng; Zheng Guo; Yanbo Zhang; Jianjing Shang; Leilei Yu; Ping Fu; Yizhi Liu; Xingang Li; Hao Wang; Ling Ren; Wei Zhang; Haifeng Hou; et al. (EPMA Journal, 2022)
Background Recognising the early signs of ischemic stroke (IS) in emergency settings has been challenging. Machine learning (ML), a robust tool for predictive, preventive and personalised medicine (PPPM/3PM), presents a possible solution for this issue and produces accurate predictions for real-time data processing. Methods This investigation evaluated 4999 IS patients among a total of 10,476 adults included in the initial dataset, and 1076 IS subjects among 3935 participants in the external validation dataset. Six ML-based models for the prediction of IS were trained on the initial dataset of 10,476 participants (split participants into a training set [80%] and an internal validation set [20%]). Selected clinical laboratory features routinely assessed at admission were used to inform the models. Model performance was mainly evaluated by the area under the receiver operating characteristic (AUC) curve. Additional techniques—permutation feature importance (PFI), local interpretable model-agnostic explanations (LIME), and SHapley Additive exPlanations (SHAP)—were applied for explaining the black-box ML models. Results Fifteen routine haematological and biochemical features were selected to establish ML-based models for the prediction of IS. The XGBoost-based model achieved the highest predictive performance, reaching AUCs of 0.91 (0.90–0.92) and 0.92 (0.91–0.93) in the internal and external datasets respectively. PFI globally revealed that demographic feature age, routine haematological parameters, haemoglobin and neutrophil count, and biochemical analytes total protein and high-density lipoprotein cholesterol were more influential on the model’s prediction. LIME and SHAP showed similar local feature attribution explanations. Conclusion In the context of PPPM/3PM, we used the selected predictors obtained from the results of common blood tests to develop and validate ML-based models for the diagnosis of IS. The XGBoost-based model offers the most accurate prediction. By incorporating the individualised patient profile, this prediction tool is simple and quick to administer. This is promising to support subjective decision making in resource-limited settings or primary care, thereby shortening the time window for the treatment, and improving outcomes after IS.

Failure mechanism of a high-locality colluvial landslide in Wanzhou County, Chongqing, China - Ling Huang; Tianyou Zhou; Shengming Zhuang; Taixin Peng; Junchao Wang; Yong Li (Bulletin of Engineering Geology and the Environment, 2022)

FLO8 deletion leads to decreased adhesion and virulence with downregulated expression of EPA1, EPA6, and EPA7 in Candida glabrata - Jun-Tao Zhao; Ke-Zhi Chen; Jin-Yan Liu; Wei-Hua Li; Yu-Zhu Wang; Lu-Ling Wang; Ming-Jie Xiang (Brazilian Journal of Microbiology, 2022)

Lycopene Alleviates Titanium Dioxide Nanoparticle-Induced Testicular Toxicity by Inhibiting Oxidative Stress and Apoptosis in Mice - Xiaojia Meng; Li Li; Hongmei An; Yaxin Deng; Chunmei Ling; Tianjiao Lu; Guanling Song; Yan Wang (Biological Trace Element Research, 2022)

Spatiotemporal distribution of sea-island prehistoric dune sites, Holocene sea levels, and aeolian sand activities in Fujian Province, China - Jianhui Jin; Zhiyong Ling; Zhizhong Li; Xinxin Zuo; Xuechun Fan; Yunming Huang; Xiaoyang Wang; Changfu Wei; Yongqing Ren; Junjie Qiu (Journal of Geographical Sciences, 2022)

Genomic analysis of a recombinant coxsackievirus A19 identified in Xinxiang, China, in 2019 - Liang Yi; Li Zhang; Linlin Feng; Xubo Luan; Qian Zhao; Pengwei Xu; Yinbiao Wang; Ling Tao; Weidong Wu (Archives of Virology, 2022)

Geographic distance, sedimentation, and substrate shape cryptic crustose coralline algal assemblages in the world’s largest subtropical intertidal algal reef - Shing Hei Zhan; Ling Chen; Chen‐Pan Liao; Wun‐Ruei Chang; Cheng‐Chin Li; Guang‐You Tang; Ching‐Yu Liou; Wei‐Lung Wang; Shih‐Wei Wang; Shao‐Lun Liu (Molecular Ecology, 2022)
Algal reefs, concreted by crustose coralline algae (CCA), are the main biotic reefs in temperate waters but rare in the subtropics and tropics. The world's largest known intertidal algal reef in the subtropics is the Taoyuan Algal Reef (TAR) located in the northwestern coast of Taiwan. The biodiversity and ecology of the TAR are scarcely explored, and now the reef is imperiled by industrialization. Here, we document cryptic species of CCA in Taiwan, particularly the TAR, by sequencing the psb A genes of over 1800 specimens collected across Taiwan. We also examine the ecological background of the TAR by surveying its benthic composition and measuring its environmental parameters. Our data reveal that the TAR harbours a high diversity of cryptic CCA species (27 molecular operational taxonomic units, or mOTUs), many of which are potentially new to science (18 mOTUs) and/or endemic to the TAR (9 mOTUs). Comparing the CCA species inventory of the TAR with the rest of Taiwan shows that the TAR represents a unique hotspot of CCA taxa in the waters of Taiwan. Our analyses show that variation in the CCA assemblages in the TAR is associated with geographic distance, sedimentation, and substrate type (for example, reef vs. hermit crab shell), suggesting that dispersal limitation and contemporary environmental selection shape the CCA assemblages in the TAR. The data from this study can inform the monitoring of human impacts on the health of the TAR and contribute to our understanding of the ecological processes underlying algal reef development.

Functional differentiation and complementation of alkaline phosphatases and choreography of DOP scavenging in a marine diatom - Kaidian Zhang; Jiashun Li; Jierui Wang; Xin Lin; Ling Li; Yanchun You; Xiaomei Wu; Zhi Zhou; Senjie Lin (Molecular Ecology, 2022)
Facing phosphate deficiency, phytoplankton use alkaline phosphatase (AP) to scavenge dissolved organophosphate (DOP). AP is a multitype (e.g., PhoA, PhoD) family of hydrolases and is known as a promiscuous enzyme with broad DOP substrate compatibility. Yet, whether the multiple types differentiate on substrates and collaborate to provide physiological flexibility remain elusive. Here we identify PhoA and PhoDs and document the functional differentiation between PhoA and a PhoD (PhoD_45757) in Phaeodactylum tricornutum . CRISPR/Cas9‐based mutations and physiological analyses reveal that (1) PhoA is a secreted enzyme and contributes the majority of total AP activity whereas PhoD_45757 is intracellular and contributes a minor fraction of the total AP activity, (2) AP gene expression compensates for each other after one is disrupted, (3) the DOP→PhoA→phosphate_uptake and the DOP_uptake→PhoD→phosphate pathways function interchangeably for some DOP substrates. These findings shed light on the underpinning of AP’s multiformity and have important implications in phytoplankton phosphorus‐nutrient niche differentiation, physiological plasticity, and competitive strategy.

Quinoline, with the active site of 8‐hydroxyl, efficiently inhibits Micropterus salmoides rhabdovirus (MSRV) infection in vitro and in vivo - Bo‐Yang Li; Fei Yang; Zhong‐Yu Zhang; Yu‐Feng Shen; Tao Wang; Liang Zhao; Jia‐Cheng Qin; Fei Ling; Gao‐Xue Wang (Journal of Fish Diseases, 2022)
Micropterus salmoides rhabdovirus (MSRV) is an significant pathogen that causes high mortality and related economic losses in bass aquaculture. There is no effective or approved therapy to date. In this study, we evaluated the anti‐MSRV effects of 22 quinoline derivatives in grass carp ovary (GCO) cells. Among these compounds, 8‐hydroxyquinoline exhibited valid inhibition in decreasing MSRV nucleoprotein gene expression levels of 99.3% with a half‐maximal inhibitory concentrations (IC 50 ) value of 4.66 μM at 48 h. Moreover, 8‐hydroxyquinoline significantly enhanced a protective effect in GCO cells by reducing the cytopathic effect (CPE). By comparing the anti‐MSRV activity of 22 quinoline derivatives, we found that 8‐hydroxyquinoline possessed the efficient active site of 8‐hydroxyl and inhibited MSRV infection in vitro. For in vivo studies, 8‐hydroxyquinoline via intraperitoneal injection exhibited an antiviral effect in MSRV‐infected largemouth bass by substantially enhancing the survival rate by 15.0%. Importantly, the viral loads in the infected largemouth bass notably reduced in the spleen on the third days post‐infection. Overall, 8‐hydroxyquinoline was considered to be an efficient agent against MSRV in aquaculture.

P-Limitation Promotes Carbon Accumulation and Sinking of Emiliania huxleyi Through Transcriptomic Reprogramming - Cong Wang; Jingtian Wang; Ling Li; Yujie Wang; Senjie Lin (Frontiers in Marine Science, 2022)
Global warming is expected to cause decreases in nutrient availability, photosynthesis, and potentially carbon export in the ocean. But how, and by what molecular mechanisms, nutrient limitation affects biological pump (BP) efficiency of phytoplankton are poorly understood. Here, using transcriptomics, miRNAomics, and physiological measurements, we report that phosphorus (P)-limitation increased cellular carbon and calcium contents and sinking rate of the cosmopolitan phytoplankton Emiliania huxleyi . Under P-limitation, when photosynthesis was depressed, there were substantial increases in cellular organic (3.4-fold) and inorganic (fivefold) carbon contents due to cell division arrest and, as our transcriptomic data suggest, CO 2 incorporation into C4 compounds. Furthermore, calcification was increased by 46% through transcriptional and epigenetic regulations. An increase in sinking rate by 37-44% was detected. Although calcification releases equivalent amounts of CO 2 , the considerable increase in cellular carbon content and sinking rate far outweighed the CO 2 release, leading to an elevated efficiency of carbon export by E. huxleyi , which would partially offset the decrease in BP capacity resulting from lower growth rate under P deficiency. However, how the observed sinking rate and its increase under P limitation on the laboratory cultures will translate into BP efficiency still requires further examination using in situ or mesocosm experiments.

Hypoxia Stress Induces Tissue Damage, Immune Defense, and Oxygen Transport Change in Gill of Silver Carp (Hypophthalmichthys molitrix): Evaluation on Hypoxia by Using Transcriptomics - Xiaohui Li; Chen Ling; Qiaoxin Wang; Cui Feng; Xiangzhong Luo; Hang Sha; Guoyu He; Guiwei Zou; Hongwei Liang (Frontiers in Marine Science, 2022)
The silver carp ( Hypophthalmichthys molitrix ) is an economically, as well as environmentally, important fish that harbors low environmental hypoxia tolerance and frequently contributes to a loss of aquaculture productivity. The gill is the first tissue attacked by hypoxia; however, the response of the gills of H. molitrix to hypoxia stress at the tissue, cellular, and molecular levels has not been clearly established. The influence of hypoxia on histological features along with gene expression in silver carp gills were explored in this research. The hematoxylin and eosin-stained sections and electron microscopy examinations of gills indicated that the gill lamellae were seriously twisted, gill filaments were dehisced, and the swelling and shedding of epithelial cell layer in the gill tissue were intensified along with the degree of hypoxia. In the hypoxia, semi-asphyxia, and asphyxia groups, the gill transcriptomic assessment of shifts in key genes, as well as modulatory networks in response to hypoxic conditions revealed 587, 725, and 748 differentially expressed genes, respectively. These genes are abundant in immune response signaling cascades (e.g., complement and coagulation cascades, Nucleotide-binding and oligomerization domain (NOD)-like receptor signaling cascade, and differentiation of Th1 along with Th2 cells) and oxygen transport [e.g., MAPK, PI3K-Akt, and hypoxia-inducible factor 1 (HIF-1) signaling cascades]. Genes linked to immune response (e.g., c2 , c3 , c6 , klf4 , cxcr4 , cd45 , and cd40 ) and oxygen transport (e.g., egln1 , egln3 , epo , ldh , and vegfa ) were additionally identified. According to our findings, the silver carp may be using “HIF-1” to obtain additional oxygen during hypoxia. These findings illustrate that hypoxia stress might damage gill tissue, trigger an immunological response, and activate HIF-1 signaling to increase oxygen availability under hypoxic situations. The findings of this work will help scientists better understand the molecular mechanisms driving hypoxia responses in hypoxia-sensitive fish and speed up the development of hypoxia-resistant varieties.

Dissociable causal roles of the frontal and parietal cortices in the effect of object location on object identity detection: a TMS study - Ping Yang; Min Wang; Cimei Luo; Xuejin Ni; Ling Li (Experimental Brain Research, 2022)

Identification of fruit firmness QTL ff2.1 by SLAF-BSA and QTL mapping in melon - Dongyang Dai; Shuang Zeng; Ling Wang; Junfeng Li; Peng Ji; Huiying Liu; Yunyan Sheng (Euphytica, 2022)

Responses of photosynthesis, antioxidant enzymes, and related gene expression to nicosulfuron stress in sweet maize (Zea mays L.) - Zhen-Xing Wu; Ning-Wei Xu; Min Yang; Xiang-Ling Li; Jin-Ling Han; Xiao-Hu Lin; Qing Yang; Gui-Hua Lv; Jian Wang (Environmental Science and Pollution Research, 2022)

The relative and combined effects of herbivore assemblage and soil nitrogen on plant diversity - Minna Zhang; Bai Liu; Guangyin Li; Yingying Kuang; Xiuquan Yue; Shicheng Jiang; Jushan Liu; Ling Wang (Science China Life Sciences, 2022)

Relationship between the levels of cord blood resistin, adiponectin, CD4 and CD8 and their influence on early neonatal outcomes - Na Wang; Tiezhi Li; Ling Hao (Molecular & Cellular Toxicology, 2022)

Removal of toluene and SO2 by hierarchical porous carbons: a study on adsorption selectivity and mechanism - Xinlei Huang; Hongxian Li; Ling Wang; Minghui Tang; Shengyong Lu (Environmental Science and Pollution Research, 2022)

Development of a Label-Free Colorimetric Aptasensor with Rationally Utilized Aptamer for Rapid Detection of Okadaic Acid - Xiaochen Yan; Xiaoyan Qi; Yinglin Zhao; Ling Li; Rui Ma; Lele Wang; Sai Wang; Xiangzhao Mao (Journal of Ocean University of China, 2022)

Preparation and In Vitro and In Vivo Evaluation of a Testosterone Film Forming Gel for the Treatment of Hypoactive Sexual Desire Disorder in Women - Jia Zeng; Tan-Fang Xie; Ting Huang; Fang Li; Zhi-Ping Wang; Ling-Lin Feng (AAPS PharmSciTech, 2022)

Large herbivores facilitate a dominant grassland forb via multiple indirect effects - Zhiwei Zhong; Xiaofei Li; Christian Smit; Tianyun Li; Ling Wang; Valeria Aschero; Diego Vázquez; Mark Ritchie; J. Hall Cushman; Deli Wang (Ecology, 2022)
While large herbivores are critically important components of terrestrial ecosystems and can have pronounced top‐down effects on plants, our understanding of the underlying mechanisms driving these effects remains incomplete. Large herbivores can alter plant growth, reproduction, and abundance through direct effects (predominantly consumption) and through indirect effects via altered interactions with abiotic factors and other species. We know considerably less about these indirect effects than the direct effects. Here, we integrate medium‐ and small‐scale field experiments to investigate how a large vertebrate herbivore, cattle ( Bos taurus ), affects the aboveground biomass of a dominant forb species, Artemisia scoparia , via diverse direct and indirect pathways in a temperate grassland in northeast China. Although cattle consumed this forb, its biomass increased significantly in response to grazing, due to multiple indirect positive effects that outweighed the direct negative effects of consumption. Cattle preferentially consumed the competing grass Leymus chinensis , and altered Artemisia microhabitats by reducing total plant cover and litter biomass and by increasing the abundance of co‐occurring ant species (e.g., Formica spp. and Lasius spp.). This led to additional indirect positive effects on A. scoparia likely due to (1) increased light availability in understory layers and other limiting resources (e.g., soil nutrients and moisture) caused by removal of competitors and plant litter at the soil surface and (2) the changes in resource availability (e.g., soil nutrients and moisture) associated with ant colonies. Our results show that large herbivores can affect plant growth not only via direct consumption, but also via multiple indirect effects. Focusing on the causes and consequences of herbivore‐induced indirect effects will not only help us to better understand the influence of these animals in ecological systems, but will also lead to more effective land management and conservation practices in the regions they inhabit.

Structure, antioxidant property and protection on PC12 of a polysaccharide isolated and screened from Abelmoschus esculentus L.Moench (okra) - Li-Chao Pan; Yang-Yang Sun; Xiao-Ling Zhang; Zhen-Yuan Zhu; Chun-Yu Liu; Hui-Qing Sun; Xue-Qing Geng; Wei Jiang; Jia-He Wang (Natural Product Research, 2022)

Screening and identification of HLA-A2-restricted neoepitopes for immunotherapy of non-microsatellite instability-high colorectal cancer - Ranran Shi; Yubing Li; Ling Ran; Yu Dong; Xiuman Zhou; Jingwen Tang; Lu Han; Mingshuang Wang; Liwei Pang; Yuanming Qi; Yahong Wu; Yanfeng Gao (Science China Life Sciences, 2022)

Transcriptomic analyses reveal the effect of nitric oxide on the lateral root development and growth of mangrove plant Kandelia obovata - Ming-Yue Wei; Huan Li; You-Hui Zhong; Zhi-Jun Shen; Dong-Na Ma; Chang-Hao Gao; Yi-Ling Liu; Wen-Hua Wang; Jing-Ya Zhang; Yan-Ping You; Hai-Lei Zheng (Plant and Soil, 2022)

Recapitulating lipid accumulation and related metabolic dysregulation in human liver-derived organoids - Ling Wang; Meng Li; Bingting Yu; Shaojun Shi; Jiaye Liu; Ruyi Zhang; Ibrahim Ayada; Monique M. A. Verstegen; Luc J. W. van der Laan; Maikel P. Peppelenbosch; Wanlu Cao; Qiuwei Pan (Journal of Molecular Medicine, 2022)

Optimal coupling combinations between dripper discharge and irrigation interval of maize for seed production under plastic film-mulched drip irrigation in an arid region - Shimeng Ma; Ling Tong; Shaozhong Kang; Sufen Wang; Xuanyi Wu; Xiaona Cheng; Qiangqiang Li (Irrigation Science, 2022)

Biological monitoring and health assessment of 21 metal(loid)s in children and adolescents in Liuzhou City, Southwest China - Yaping Li; Yu Zhang; Meng Yu; Liqin Hu; Ting Zeng; Ling Liu; Limei Wang; Liangqiong Deng; Xiang Li; Ping Liu; Dingyuan Zeng; Surong Mei (Environmental Science and Pollution Research, 2022)

Using Caenorhabditis elegans to assess the ecological health risks of heavy metals in soil and sediments around Dabaoshan Mine, China - Xin Li; Qingqing Yang; Ling Wang; Chuxin Song; Lufeng Chen; Jie Zhang; Yong Liang (Environmental Science and Pollution Research, 2022)

Effectiveness of Disinfectants Suitable for Inactivating SARS-CoV-2 at Cold-Chain Temperature - Xiaosong Wu; Yin Chen; Ling Wang; Xiling Guo; Lunbiao Cui; Yiming Shen; Fang Li; Hong Sun; Liubo Zhang; Jin Shen; Yan Xu (Food and Environmental Virology, 2022)

Dysfunction of FadA‐cAMP signalling decreases Aspergillus flavus resistance to antimicrobial natural preservative Perillaldehyde and AFB1 biosynthesis - Kunlong Yang; Qingru Geng; Yue Luo; Rui Xie; Tongzheng Sun; Zhen Wang; Ling Qin; Wei Zhao; Man Liu; Yongxin Li; Jun Tian (Environmental Microbiology, 2022)
Summary Aspergillus flavus is an opportunistic fungal pathogen that colonizes agriculture crops with aflatoxin contamination. We found that Perillaldehyde (PAE) effectively inhibited A . flavus viability and aflatoxin production by inducing excess reactive oxygen species (ROS). Transcriptome analysis indicated that the Gα protein FadA was significantly induced by PAE. Functional characterization of FadA showed it is important for asexual development and aflatoxin biosynthesis by regulation of cAMP‐PKA signalling. The Δ fadA mutant was more sensitive to PAE, while Δ pdeL and Δ pdeH mutants can tolerate excess PAE compared to wild‐type A . flavus . Further RNA‐sequence analysis showed that fadA was important for expression of genes involved in oxidation–reduction and cellular metabolism. The flow cytometry and fluorescence microscopy demonstrated that Δ fadA accumulated more concentration of ROS in cells, and the transcriptome data indicated that genes involved in ROS scavenging were downregulated in Δ fadA mutant. We further found that FadA participated in regulating response to extracellular environmental stresses by increasing phosphorylation levels of MAPK Kinase Slt2 and Hog1. Overall, our results indicated that FadA signalling engages in mycotoxin production and A . flavus resistance to antimicrobial PAE, which provide valuable information for controlling this fungus and AF biosynthesis in pre‐ and postharvest of agricultural crops.

Increased abscisic acid sensitivity and drought tolerance of Arabidopsis by overexpression of poplar abscisic acid receptors - Qing Li; Qianqian Tian; Yue Zhang; Mengxue Niu; Xiaoqian Yu; Conglong Lian; Chao Liu; Hou-Ling Wang; Weilun Yin; Xinli Xia (Plant Cell, Tissue and Organ Culture (PCTOC), 2022)

A Reliable Murine Model of Disseminated Infection Induced by Talaromyces Marneffei - Juan He; Jia-Sheng Li; Hong-Yan Xu; Yi-Qun Kuang; Jun Li; Hong-Bin Li; Zhe Li; Hui-Ling Zhou; Rui-Rui Wang; Yu-Ye Li (Mycopathologia, 2022)

Reference gene selection for quantitative RT-PCR in Miscanthus sacchariflorus under abiotic stress conditions - Junqin Zong; Jingbo Chen; Ling Li; Jianjian Li; Dandan Li; Jingjing Wang; Jun Liu; Jianxiu Liu (Molecular Biology Reports, 2022)

Estrogen alleviates hepatocyte necroptosis depending on GPER in hepatic ischemia reperfusion injury - Zhonglin Li; Liuying Chen; Huikuan Chu; Weijun Wang; Ling Yang (Journal of Physiology and Biochemistry, 2022)

GNG12 Targeted by miR-876-5p Contributes to Glioma Progression Through the Activation of the PI3K/AKT Signaling Pathway - Ling Li; Qiuying Zhang; Leyong Yuan; Yanlong Yang; Xiaobo Wang; Fangfang Liu; Yang Liu; Mingshui Xie (Journal of Molecular Neuroscience, 2022)

The influences of α-hemolytic Streptococcus on class switching and complement activation of human tonsillar cells in IgA nephropathy - Muyao Ye; Chang Wang; Ling Li; Qiulan Zhao; Youming Peng; Hong Liu (Immunologic Research, 2022)

Janibacter endophyticus sp. nov., an Endophytic Actinobacterium Isolated from the Root of Paris polyphylla Smith var. Yunnanensis - Zhen Zhang; En-Min Zhou; Cong-Jian Li; Xing-Wang Jiang; Rui-Feng Mao; Jing-Ran Liu; Xiao-Yang Zhi; Ling-Ling Yang (Current Microbiology, 2022)

Methods for the construction of DEMs of artificial slopes considering morphological features and semantic information - Yan Xu; Ming-wei Zhao; Jie Lu; Chun Wang; Ling Jiang; Can-can Yang; Xiao-li Huang (Journal of Mountain Science, 2022)

Neobacillus paridis sp. nov., an endophyte of Paris polyphylla Smith var. yunnanensis - Peng-Chao Zhan; Cong-Jian Li; Zhen Zhang; Rui-Feng Mao; Jing-Ran Liu; Xing-Wang Jiang; Xiao-Yang Zhi; Ling-Ling Yang (Archives of Microbiology, 2022)

Special roles for efflux systems in iron homeostasis of non‐siderophore‐producing cyanobacteria - Ling‐Mei Liu; Ding‐Lan Li; Bin Deng; Xin‐Wei Wang; Hai‐Bo Jiang (Environmental Microbiology, 2022)
Summary In oligotrophic oceans, low bioavailability of Fe is a key factor limiting primary productivity. However, excessive Fe in cells leads to the Fenton reaction, which is toxic to cells. Cyanobacteria must strictly maintain intracellular Fe homeostasis. Here, we knocked out a series of genes encoding efflux systems in Synechocystis sp. PCC 6803, and found eight genes that are required for high Fe detoxification. Unexpectedly, the HlyBD‐TolC efflux system plays an important role in the adaptation of Synechocystis under Fe‐deficient conditions. Mutants of HlyD and TolC grew worse than the wild‐type strain under low‐Fe conditions and showed significantly lower intracellular Fe contents than the wild‐type strain. We excluded the possibility that the low Fe sensitivity of the HlyBD‐TolC mutants was caused by a loss of the S‐layer, the main extracellular protein secreted via this efflux system. Inactivation of the HlyD protein influenced type IV pili formation and direct inactivation of type IV pili related genes affected the adaptation to low‐Fe conditions. HlyBD‐TolC system is likely involved in the formation of type IV pili and indirectly influenced Fe acquisition. Our findings suggest that efflux system in non‐siderophore‐producing cyanobacteria can facilitate Fe uptake and help cells adapt to Fe‐deficient conditions via novel pathways.

The regulatory role of dietary factors in skeletal muscle development, regeneration and function - Liyi Wang; Ziye Xu; Defeng Ling; Jie Li; Yizhen Wang; Tizhong Shan (Critical Reviews in Food Science and Nutrition, 2022)

Fruit and vegetable consumption, cardiovascular disease, and all-cause mortality in China - Jun Wang; Fangchao Liu; Jianxin Li; Keyong Huang; Xueli Yang; Jichun Chen; Xiaoqing Liu; Jie Cao; Shufeng Chen; Chong Shen; Ling Yu; Fanghong Lu; et al. (Science China Life Sciences, 2022)

Correction to: Optimal coupling combinations between dripper discharge and irrigation interval of maize for seed production under plastic film-mulched drip irrigation in an arid region - Shimeng Ma; Ling Tong; Shaozhong Kang; Sufen Wang; Xuanyi Wu; Xiaona Cheng; Qiangqiang Li (Irrigation Science, 2022)

Spatio-temporal analysis of the coupling relationship between urbanization and eco-environment in backward regions of China - Hao Chen; Ling Liu; Jiaohui Fang; Changchao Li; Lifei Wang; Quan Quan; Jian Liu (Environmental Science and Pollution Research, 2022)

Paracoccus shandongensis sp. nov., Isolated from Activated Sludge - Xiao-Fan Gong; Fang Wang; Dong Meng; Yu-Ling Liu; Peng-Fei Gu; Xiang-Yu Fan; Zhao-Song Huang; Zong-Jun Du; Qiang Li (Current Microbiology, 2022)

Identification of bacterial blight resistance genes in rice landraces from Yunnan Province, China - Caimei Zhao; Fuyou Yin; Ling Chen; Dingqin Li; Suqin Xiao; Qiaofang Zhong; Bo Wang; Xue Ke; Jian Fu; Xiang Li; Yue Chen; Lingxian Wang; et al. (Australasian Plant Pathology, 2022)
Bacterial blight (BB), a serious bacterial disease caused by pathogen Xanthomonas oryzae pv. oryzae ( Xoo ) affects rice growth and yield. Yunnan Province is regarded as a center of rice diversity in China and indeed the world, and has abundant rice landrace resources, which may offer prospective candidate donors in rice improvement and breeding. In this study, a set of 200 rice landraces were evaluated to determine their resistance to 10 pathogenic Xoo strains resistance by the leaf-clipping method. The results indicated that the tested rice landraces had different resistance levels against different Xoo strains. Multiple comparisons showed that the Xoo strain PXO99 was virulent to the tested rice landraces. Sixty-six rice landraces conferred resistance against at least one Xoo strain. These resistant rice landraces screened were then performed the presence of 14 cloned BB resistance genes by closely linked molecular markers and designed specific primers. The results showed that none of these resistant accessions contained xa13 , Xa21 , Xa27 , and Xa45(t) homologous fragments, while 9, 24, 4, 7, 9, 15, 1, 5, 4 and 27 accessions contained Xa1 , Xa2/Xa31(t) , Xa14 , Xa3/Xa26 , Xa4 , xa5 , Xa7 , Xa10 , Xa23 and xa25 homologous fragments, respectively. Sequence analysis further revealed that nucleotide variations around functional nucleotide polymorphisms region were observed within these accessions containing the Xa1 , Xa2/Xa31(t) , Xa14 , Xa3/Xa26 , Xa4 , xa5 , Xa10 , Xa23 and xa25 homologous fragments. These results along with phenotypic resistance spectrum supported that these accessions carried nine resistance homologous genes. Only one accession (Qishanggu_Wenshan) carried the Xa7 resistance gene. We also found that some resistant rice landraces, especially Xilandigu_Baoshan, and Laoyaling_Lincang without the above resistance genes, which mediated broad spectrum resistance to multiple Xoo strains, were identified as potential sources for breeding rice lines resistance to BB.

Deinococcus aestuarii sp. nov. and Deinococcus aquaedulcis sp. nov., two novel resistant bacteria isolated from pearl river estuary - Ling-Zi Yin; Jia-Ling Li; Ze-Tao Liu; Bao-Zhu Fang; Pandeng Wang; Xiao-Qing Luo; Lei Dong; Li Duan; Shan-Hui Li; Wen-Jun Li (Antonie van Leeuwenhoek, 2022)

Biogeography of culturable marine bacteria from both poles reveals that ‘everything is not everywhere’ at the genomic level - Qi‐Long Qin; Zhi‐Bin Wang; Qian‐Qian Cha; Sha‐Sha Liu; Xue‐Bing Ren; Hui‐Hui Fu; Mei‐Ling Sun; Dian‐Li Zhao; Andrew McMinn; Yin Chen; Xiu‐Lan Chen; Yu‐Zhong Zhang; et al. (Environmental Microbiology, 2022)
Summary Based on 16S rRNA gene analyses, the same bacterial operational taxonomic units (OTUs) are common to both the Arctic and Antarctic oceans, supporting the concept ‘everything is everywhere’. However, whether the same OTUs from both poles have identical genomes, i.e. whether ‘everything is still everywhere’ at the genomic level has not yet been examined systematically. Here, we isolated, sequenced and compared the genomes of 45 culturable marine bacteria belonging to three genera of Salinibacterium , Psychrobacter and Pseudoalteromonas from both polar oceans. The bacterial strains with identical 16S rRNA genes were common to both poles in every genus, and four identical genomes were detected in the genus Salinibacterium from the Arctic region. However, no identical genomes were observed from opposite poles in this study. Our data, therefore, suggest that ‘everything is not everywhere’ at the genomic level. The divergence time between bacteria is hypothesized to exert a strong impact on the bacterial biogeography at the genomic level. The geographical isolation between poles was observed for recently diverged, highly similar genomes, but not for moderately similar genomes. This study thus improves our understanding of the factors affecting the genomic‐level biogeography of marine microorganisms isolated from distant locations.

Genome-Wide Identification and Expression Analysis of AP2/EREBP Transcription Factors in Litchi (Litchi chinensis Sonn.) - Jia-li Men; Fang Li; Jin-hua Sun; Guo Wang; Huan-ling Li; Shu-jun Wang; Yun Xu; Jia-bao Wang (Tropical Plant Biology, 2021)
APETALA2/ethylene response element binding proteins (AP2/EREBP) are a vital type of TF involved in plant organ development and embryogenesis. In this study we identified 202 Litchi AP2/EREBP TFs from the litchi genome. They were classified into four subfamilies by phylogenetic clustering, including AP2s (20), ERFs (112), DREBs (64), and RAVs (6). Analysis of conserved domains, motifs, gene structure, and genome localization were carried out to investigate the evolutionary features of litchi AP2/EREBPs. Over 35% of DREBs and ERFs involved in the expansion of litchi AP2/EREBPs resulted from tandem duplication. The majority of genomic organizations were conservative, except those of the AP2 subfamily, which had no intron and contained less conservative motif numbers. The expression profiles of litchi AP2/EREBPs in ten tissues were investigated using RNA-Seq data and fifty-nine showed tissue-specific expressions. Their expression patterns were confirmed by qRT-PCR with eight tissues-specificity genes. Six genes related to embryogenesis were identified using the map of orthologous gene interaction between Arabidopsis and litchi. This paper is a comprehensive report on the characteristics of the litchi AP2/EREBP gene superfamily. It will serve to further explore the regulatory mechanisms of AP2/EREBP TFs in the litchi somatic embryogenesis and provide information for litchi molecular breeding.

The Key Regulator of Necroptosis, RIP1 Kinase, Contributes to the Formation of Astrogliosis and Glial Scar in Ischemic Stroke - Yong-Ming Zhu; Liang Lin; Chao Wei; Yi Guo; Yuan Qin; Zhong-Sheng Li; Thomas A. Kent; Claire E. McCoy; Zhan-Xiang Wang; Yong Ni; Xian-Yong Zhou; Hui-Ling Zhang (Translational Stroke Research, 2021)
Necroptosis initiation relies on the receptor-interacting protein 1 kinase (RIP1K). We recently reported that genetic and pharmacological inhibition of RIP1K produces protection against ischemic stroke-induced astrocytic injury. However, the role of RIP1K in ischemic stroke-induced formation of astrogliosis and glial scar remains unknown. Here, in a transient middle cerebral artery occlusion (tMCAO) rat model and an oxygen and glucose deprivation and reoxygenation (OGD/Re)-induced astrocytic injury model, we show that RIP1K was significantly elevated in the reactive astrocytes. Knockdown of RIP1K or delayed administration of RIP1K inhibitor Nec-1 down-regulated the glial scar markers, improved ischemic stroke-induced necrotic morphology and neurologic deficits, and reduced the volume of brain atrophy. Moreover, knockdown of RIP1K attenuated astrocytic cell death and proliferation and promoted neuronal axonal generation in a neuron and astrocyte co-culture system. Both vascular endothelial growth factor D (VEGF-D) and its receptor VEGFR-3 were elevated in the reactive astrocytes; simultaneously, VEGF-D was increased in the medium of astrocytes exposed to OGD/Re. Knockdown of RIP1K down-regulated VEGF-D gene and protein levels in the reactive astrocytes. Treatment with 400 ng/ml recombinant VEGF-D induced the formation of glial scar; conversely, the inhibitor of VEGFR-3 suppressed OGD/Re-induced glial scar formation. RIP3K and MLKL may be involved in glial scar formation. Taken together, these results suggest that RIP1K participates in the formation of astrogliosis and glial scar via impairment of normal astrocyte responses and enhancing the astrocytic VEGF-D/VEGFR-3 signaling pathways. Inhibition of RIP1K promotes the brain functional recovery partially via suppressing the formation of astrogliosis and glial scar. Graphical Abstract

Hyper-SUMOylation of SMN induced by SENP2 deficiency decreases its stability and leads to spinal muscular atrophy-like pathology - Yuhong Zhang; Xu Chen; Qiqi Wang; Congcong Du; Wenbin Lu; Hong Yuan; Zhenzhen Zhang; Danqing Li; Xing Ling; Xiang Ren; Yang Zhao; Qi Su; et al. (Journal of Molecular Medicine, 2021)

Involvement of METTL3/m6Adenosine and TGFβ/Smad3 signaling on Tenon’s fibroblasts and in a rabbit model of glaucoma surgery - Yan Liu; Chao Gu; Xiabin Li; Tingwei Wang; Ling Yu (Journal of Molecular Histology, 2021)

Antimicrobial Natural Products Produced by Soil-Derived Fungus Penicillium cremeogriseum W1-1 - Xu-Yan Sang; Zhao-Jie Wang; Ya-Bin Yang; Yong-Liang Wang; Mei-Ling Xiang; Dou-Ying Zhu; Ying Zhou; Xiao-Dong Luo; Li-Xing Zhao (Indian Journal of Microbiology, 2021)

Controls of Wind-Driven Jet on the Distribution of Pelagic Cnidarians in the Midwestern South China Sea - Ruping Ge; Hongju Chen; Ling Li; Guangxing Liu; Bangqin Huang; Lisha Wang; Yunyun Zhuang; Xin Liu (Frontiers in Marine Science, 2021)
The coastal water transported by the combined action of southwest wind jet and anticyclonic eddy substantially influences the biological processes in the midwestern South China Sea. However, how the wind-driven jet affects the zooplankton community remains unclear. In this study, the species number, abundance, and vertical distribution of medusae were investigated in the wind-driven jet (WJR) and non-wind-driven jet regions (NWJR). The low-salinity and nutrient-rich coastal water substantially influenced species composition, abundance, and vertical distribution of medusae in the WJR. The species number of the meroplanktonic hydromedusae in the WJR was approximately twice that in the NWJR due to the horizontal transport of wind-driven jets. The abundances of holoplanktonic hydromedusae in WJR were 38.2 ± 9.3 ind⋅m –3 , which were thrice of that in the NWJR regions, caused by the abundant diet in the WJR. Additionally, only the abundance of medusae above the thermocline was affected by the coastal water in WJR, while these showed no significant difference below the thermocline between the WJR and the NWJR. Generalized additive model analyses suggested that the diet was the most important factor affecting the abundance of the holoplanktonic hydromedusae and siphonophore, whereas meroplanktonic hydromedusae were influenced by the combination of temperature, salinity, and diet.

Ice-binding proteins: a remarkable ice crystal regulator for frozen foods - Xu Chen; Xiaodan Shi; Xixi Cai; Fujia Yang; Ling Li; Jinhong Wu; Shaoyun Wang (Critical Reviews in Food Science and Nutrition, 2021)

Efficiency and comprehensive risk assessment of soil Pb and Cd by washing technique with three biodegradable eluents - Qinmei Zhong; Shirong Zhang; Xiaomei Pan; Guiyin Wang; Xiaoxun Xu; Ting Li; Wei Zhou; Yan He; Ling Luo; Yan Liu; Lulu Long (Environmental Science and Pollution Research, 2021)

Terpenoid indole alkaloid biosynthesis in Catharanthus roseus: effects and prospects of environmental factors in metabolic engineering - Yongliang Liu; Barunava Patra; Sanjay Kumar Singh; Priyanka Paul; Yan Zhou; Yongqing Li; Ying Wang; Sitakanta Pattanaik; Ling Yuan (Biotechnology Letters, 2021)
Plants synthesize a vast array of specialized metabolites that primarily contribute to their defense and survival under adverse conditions. Many of the specialized metabolites have therapeutic values as drugs. Biosynthesis of specialized metabolites is affected by environmental factors including light, temperature, drought, salinity, and nutrients, as well as pathogens and insects. These environmental factors trigger a myriad of changes in gene expression at the transcriptional and posttranscriptional levels. The dynamic changes in gene expression are mediated by several regulatory proteins that perceive and transduce the signals, leading to up- or down-regulation of the metabolic pathways. Exploring the environmental effects and related signal cascades is a strategy in metabolic engineering to produce valuable specialized metabolites. However, mechanistic studies on environmental factors affecting specialized metabolism are limited. The medicinal plant Catharanthus roseus (Madagascar periwinkle) is an important source of bioactive terpenoid indole alkaloids (TIAs), including the anticancer therapeutics vinblastine and vincristine. The emerging picture shows that various environmental factors significantly alter TIA accumulation by affecting the expression of regulatory and enzyme-encoding genes in the pathway. Compared to our understanding of the TIA pathway in response to the phytohormone jasmonate, the impacts of environmental factors on TIA biosynthesis are insufficiently studied and discussed. This review thus focuses on these aspects and discusses possible strategies for metabolic engineering of TIA biosynthesis. Purpose of work Catharanthus roseus is a rich source of bioactive terpenoid indole alkaloids (TIAs). The objective of this work is to present a comprehensive account of the influence of various biotic and abiotic factors on TIA biosynthesis and to discuss possible strategies to enhance TIA production through metabolic engineering.

Seasonal freezing-thawing process and hydrothermal characteristics of soil on the Loess Plateau, China - Ya-ling Chou; Li-jie Wang (Journal of Mountain Science, 2021)

Petrogenesis and tectonic implication of lavas from the Yap Trench, western Pacific - Ling Chen; Limei Tang; Jichao Yang; Xiaohu Li; Wei Wang; Fengyou Chu; Jie Zhang (Acta Oceanologica Sinica, 2021)

Metabolic responses of Chinese perch (Siniperca chuatsi) to different levels of dietary carbohydrate - Yanpeng Zhang; Xu-fang Liang; Shan He; Jie Wang; Ling Li; Zhen Zhang; Jiao Li; Xu Chen; Lu Li; Muhammad Shoaib Alam (Fish Physiology and Biochemistry, 2021)

Effects of climate variables on the transmission of COVID-19: a systematic review of 62 ecological studies - Hu-Li Zheng; Ze-Li Guo; Mei-ling Wang; Chuan Yang; Shu-Yi An; Wei Wu (Environmental Science and Pollution Research, 2021)

Gibberellic acid application on biomass, oxidative stress response, and photosynthesis in spinach (Spinacia oleracea L.) seedlings under copper stress - Qin Gong; Zhao-hua Li; Ling Wang; Jing-yi Zhou; Qun Kang; Duan-dan Niu (Environmental Science and Pollution Research, 2021)

Soil heavy metal pollution source analysis based on the land use type in Fengdong District of Xi’an, China - Huijuan Hu; Ling Han; Liangzhi Li; Haiyang Wang; Tangqi Xu (Environmental Monitoring and Assessment, 2021)

A new strategy combined HASM and classical interpolation methods for DEM construction in areas without sufficient terrain data - Jing Wang; Ming-wei Zhao; Ling Jiang; Can-can Yang; Xiao-li Huang; Yan Xu; Jie Lu (Journal of Mountain Science, 2021)

Deep profile soil moisture distribution characteristics for different micro-topographies on the semi-arid Loess Plateau, China - Qing-ping Gou; Qing-ke Zhu; Yi-xuan Li; Xiang-lei Tian; Peng-xiang Wang; Yun-ling Xin; Shu-yuan Luo (Journal of Mountain Science, 2021)

Degraded polysaccharides from Porphyra haitanensis: purification, physico-chemical properties, antioxidant and immunomodulatory activities - Yun-Feng Huo; Yin-Ting Li; Wei Xia; Chong Wang; Yuan-Yuan Xie; Yan-Bo Wang; Tao Zhou; Ling-Lin Fu (Glycoconjugate Journal, 2021)

Chryseobacterium paridis sp. nov., an endophytic bacterial species isolated from the root of Paris polyphylla Smith var. yunnanensis - Zhen Zhang; Ling-Ling Yang; Cong-Jian Li; Xing-Wang Jiang; Xiao-Yang Zhi (Archives of Microbiology, 2021)

Two new norsesquiterpenoids with estrogenic activity from the stems and leaves of Dioscorea oppositifolia L - Ying-Jie Ren; Yan-Gang Cao; Meng-Nan Zeng; Bei-Bei Zhang; Yan-Ling Liu; Meng-Na Wang; Yan-Li Zhang; Wei-Sheng Feng; Xiao-Ke Zheng (Natural Product Research, 2021)

Light and high-strength structure inspired by the characteristics of double-nutrient foramens in intertarsal joint of ostrich - Rui Zhang; Chengjin Wang; Shichao Fan; Dong Li; Hao Pang; Lei Ling; Jianqiao Li (Rendiconti Lincei. Scienze Fisiche e Naturali, 2021)

Co-editing PINK1 and DJ-1 Genes Via Adeno-Associated Virus-Delivered CRISPR/Cas9 System in Adult Monkey Brain Elicits Classical Parkinsonian Phenotype - Hao Li; Shihao Wu; Xia Ma; Xiao Li; Tianlin Cheng; Zhifang Chen; Jing Wu; Longbao Lv; Ling Li; Liqi Xu; Wenchao Wang; Yingzhou Hu; et al. (Neuroscience Bulletin, 2021)
Whether direct manipulation of Parkinson’s disease (PD) risk genes in the adult monkey brain can elicit a Parkinsonian phenotype remains an unsolved issue. Here, we used an adeno-associated virus serotype 9 (AAV9)-delivered CRISPR/Cas9 system to directly co-edit PINK1 and DJ-1 genes in the substantia nigras (SNs) of two monkey groups: an old group and a middle-aged group. After the operation, the old group exhibited all the classic PD symptoms, including bradykinesia, tremor, and postural instability, accompanied by key pathological hallmarks of PD, such as severe nigral dopaminergic neuron loss (>64%) and evident α-synuclein pathology in the gene-edited SN. In contrast, the phenotype of their middle-aged counterparts, which also showed clear PD symptoms and pathological hallmarks, were less severe. In addition to the higher final total PD scores and more severe pathological changes, the old group were also more susceptible to gene editing by showing a faster process of PD progression. These results suggested that both genetic and aging factors played important roles in the development of PD in the monkeys. Taken together, this system can effectively develop a large number of genetically-edited PD monkeys in a short time (6–10 months), and thus provides a practical transgenic monkey model for future PD studies.

Efficiently immobilizing uranium (VI) by oxidized carbon foam - Hongliang Bao; Chunyu Xie; Ling Han; Zenghui Yue; Yuan Qian; Linjuan Zhang; Zi-Jian Li; Huangjie Lu; Jian Lin; Jian-Qiang Wang (Environmental Science and Pollution Research, 2021)

Short-term effect of NO2 on outpatient visits for dermatologic diseases in Xinxiang, China: a time-series study - Ling Chao; Mengxue Lu; Zhen An; Juan Li; Yuchun Li; Qian Zhao; Yinbiao Wang; Yue Liu; Weidong Wu; Jie Song (Environmental Geochemistry and Health, 2021)

Characteristics of airborne microbial community in Hefei, eastern China, under a good quality in mid-spring - Li Wang; Changnian Wu; Qi Ling; Jiangying Yu; Weihua Li; Weiyue Wang; Jinkang Zhao (Aerobiologia, 2021)

Modulation of the 5-HT 3 A receptor current by desacylbaldrinal - Li-Xia Wang; Hu-Lan Chen; Hong-Ling Yan; Fei Tang; Hai Zhang; Hong-Xiang Li; Qiang Ye; Cheng Peng; Yu-Zhu Tan (Natural Product Research, 2021)

Exploring the dynamic mechanism of allosteric drug SHP099 inhibiting SHP2E69K - Shan Du; Xin-hua Lu; Wei-Ya Li; Li-Peng Li; Yang-Chun Ma; Liang Zhou; Jing-Wei Wu; Ying Ma; Run-Ling Wang (Molecular Diversity, 2021)

Phylogenomic Analyses of a Clade Within the Family Flavobacteriaceae Suggest Taxonomic Reassignments of Species of the Genera Algibacter, Hyunsoonleella, Jejuia, and Flavivirga, and the Proposal of Pseudalgibacter gen. nov. and Pseudalgibacter alginicilyticus comb. nov. - Miao Li; Ling-Zhi Hou; Xing-Hao Xu; Xiao-Xiao Wang; Ming-Can Zheng; Yan-Jiao Zhang; Ang Liu (Current Microbiology, 2021)

Effect of Nano-Titanium Dioxide on Blood-Testis Barrier and MAPK Signaling Pathway in Male Mice - Tianjiao Lu; Chunmei Ling; Mingjuan Hu; Xiaojia Meng; Yaxin Deng; Hongmei An; Li Li; Yunhua Hu; Haixia Wang; Guanling Song; Shuxia Guo (Biological Trace Element Research, 2021)

OSL chronology of a Palaeolithic site in a humid subtropical mountainous area of southeast China - Jian-hui Jin; Xiao-yang Wang; Zhen-yu Zhou; Yun-ming Huang; Xue-chun Fan; Xin-xin Zuo; Zhi-zhong Li; Zhi-yong Ling; Yong-qing Ren; Shu-tong Li (Journal of Mountain Science, 2021)

Paracoccus binzhouensis sp. nov., isolated from activated sludge - Fang Wang; Xiao-Fan Gong; Dong Meng; Yu-Ling Liu; Peng-Fei Gu; Xiang-Yu Fan; Zhao-Song Huang; Zong-Jun Du; Qiang Li (Archives of Microbiology, 2021)

A new ent -kaurane diterpene from Isodon henryi - Xue Jiang; Ling-Xia Zhang; Qing-Mei Feng; Hong Wu; Ya-Lin Liu; De-Qin Wang; Li-Ping Dai; Zhi-Min Wang (Natural Product Research, 2021)

Lignin degradation by water buffalo - Qingbiao Xu; Huimin Zhong; Jiayan Zhou; Yong Wu; Zhenhua Ma; Liguo Yang; Zhen Wang; Chuqi Ling; Xiang Li (Tropical Animal Health and Production, 2021)

Risk factors for sleep disorders in patients undergoing peritoneal dialysis - Gui-Ling Liu; Qiu-Nan Zhan; You-Lu Zhao; Zu-Ying Xiong; Jin-Lan Liao; Ye-Ping Ren; Qin Wang; Li-Ping Duan; Zhao-Xia Zheng; Li Hao; Jie Dong (Sleep and Biological Rhythms, 2021)
Sleep disorders in patients with end-stage renal disease are common but have rarely been reported in previous studies. Therefore, we examined the prevalence of sleep disorders and the risk factors for declining sleep quality in patients undergoing peritoneal dialysis (PD). A multicenter prospective cohort study was conducted at five PD centers across different provinces in China. A total of 449 patients who underwent PD between March to November 2013 were enrolled. Demographic data, laboratory indicators, presence of depression, and sleep assessment data were collected. Sleep questionnaires reflecting five categories of sleep disorders, namely, insomnia, restless legs syndrome, excessive daytime sleepiness, possible narcolepsy, and sleepwalking and nightmares, were administered at baseline and at 24 months postoperatively. Sleep disorders were diagnosed when a patient had at least one sleep problem. At baseline, 335 (74.6%) patients had at least one type of sleep disorder. Depression, diabetes mellitus (DM), and male were found to be associated with the presence of a sleep disorder. At follow-up, the prevalence of insomnia, restless legs syndrome, and excessive daytime sleepiness had significantly increased in 285 patients. Furthermore, cardiovascular disease (CVD) was found to be associated with the presence of sleep disorders in patients with one or more disorders at baseline, whereas a low serum albumin level was found to be associated with sleep disorders in patients without any sleep disorders at baseline. The prevalence of sleep disorders was relatively high among PD patients at baseline and increased afterthe2-year follow-up. Depression, DM, and male were associated with all sleep disorders at baseline. CVD was associated with the presence of a sleep disorder at baseline and worse sleep quality at the 2-year follow-up; whereas a low serum albumin level was associated with the risk of acquiring a sleep disorder at the 2-year follow-up among patients with normal sleep status at baseline.

Coexistence of endonuclease and exonuclease activities in a novel RecJ from Bacillus cereus - Liya Ma; Wen Wang; Chaozhi Hao; Li Zheng; Ling Wang; Minggang Zheng (Biotechnology Letters, 2021)

Foetidibacter luteolus gen. nov., sp. nov., isolated from the rhizosphere of Salvia miltiorrhiza - Qian Pu; Guo-hong Zeng; Gui-wei Wang; Ling-er Lu; Ang Li; Xu-rui Cheng; Xue-ying Wang; Ou Li; Cong Sun; Xiu-fang Hu (Archives of Microbiology, 2021)

Vibrio nitrifigilis sp. nov., a marine nitrogen-fixing bacterium isolated from the lagoon sediment of an islet inside an atoll - Wei-Sheng Huang; Li-Ting Wang; Jwo-Sheng Chen; Yen-Ting Chen; Sean Ting-Shyang Wei; Yin-Ru Chiang; Pei-Ling Wang; Tzong-Huei Lee; Shih-Ting Lin; Lina Huang; Wung Yang Shieh (Antonie van Leeuwenhoek, 2021)

Genome-Wide Identification and Expression Analysis of Heavy Metal Stress–Responsive Metallothionein Family Genes in Nicotiana tabacum - Qin Yu; Linshen He; Chunsong Huo; Xiaohan Jiang; Hua Chen; Run Wang; Minzhi Tang; Ling Dong; Ji Chen; Yonghao Li; Shunqin Zhu; Wanhong Liu (Plant Molecular Biology Reporter, 2021)

Rhizosphere microbiome modulated effects of biochar on ryegrass 15N uptake and rhizodeposited 13C allocation in soil - Yingyi Fu; Amit Kumar; Lijun Chen; Yuji Jiang; Ning Ling; Runze Wang; Qiong Pan; Bhupinder Pal Singh; Marc Redmile-Gordon; Lu Luan; Qin Li; Quan Shi; et al. (Plant and Soil, 2021)

Transcutaneous Auricular Vagus Nerve Stimulation: From Concept to Application - Yu Wang; Shao-Yuan Li; Dan Wang; Mo-Zheng Wu; Jia-Kai He; Jin-Ling Zhang; Bin Zhao; Li-Wei Hou; Jun-Ying Wang; Lei Wang; Yi-Fei Wang; Yue Zhang; et al. (Neuroscience Bulletin, 2021)

Combined Application of Arbuscular Mycorrhizal Fungi and Exogenous Melatonin Alleviates Drought Stress and Improves Plant Growth in Tobacco Seedlings - Ling Liu; Dong Li; Yilin Ma; Hongtao Shen; Shimin Zhao; Yanfang Wang (Journal of Plant Growth Regulation, 2021)

Substrate-Based Design of Human Farnesyltransferase Peptide-like Pain Antagonists - Baoqiang Li; Ling Zhang; Kai Wang; Jie Yang (International Journal of Peptide Research and Therapeutics, 2021)

Chelerythrine Ameliorates Pulmonary Fibrosis via Activating the Nrf2/ARE Signaling Pathway - Ling Peng; Li Wen; Qingfeng Shi; Feng Gao; Bin Huang; Changming Wang (Cell Biochemistry and Biophysics, 2021)

AICAR suppresses cell proliferation and synergizes with decitabine in myelodysplastic syndrome via DNA damage induction - Jin Liu; Long Liang; Xin Li; Yuan liang Peng; Ji Zhang; Xiao long Wang; Jing Liu; Ling Nie (Biotechnology Letters, 2021)

Differences in topological properties of functional brain networks between menstrually-related and non-menstrual migraine without aura - Yutong Zhang; Tao Xu; Ziwen Wang; Dehua Li; Jiarong Du; Yi Wen; Yu Zhao; Huaqiang Liao; Fanrong Liang; Ling Zhao (Brain Imaging and Behavior, 2021)
Menstrually-related migraine without aura refers to a specific type of migraine that is associated with the female ovarian cycle. Compared with non-menstrual migraine without aura, in menstrually-related migraine without aura, there are additional attacks of migraine outside of the menstrual period. Menstrually-related migraine without aura tends to be less responsive to acute treatment and more prone to relapse than non-menstrual migraine without aura. Currently menstrually-related migraine without aura is treated no differently from any other migraine but, the differences in the central mechanisms underlying menstrually-related migraine without aura and non-menstrual migraine without aura remain poorly understood. Here, using resting-state functional magnetic resonance imaging and graph theory approaches, we aimed to explore the differences in topological properties of functional networks in 51 menstrually-related migraine without aura patients and 47 non-menstrual migraine without aura patients. The major finding of our study was that significant differences in topological properties between the two groups were mainly evident in the nodal centrality of the inferior frontal gyrus and the thalamus. Nodal centrality in inferior frontal gyrus was negatively correlated with Headache Impact Test questionnaire scores in the menstrually-related migraine without aura patients. Partial least squares correlation analysis revealed enhanced correlations of inferior frontal gyrus to pain-related behavior in the non-menstrual migraine without aura group, while within the menstrually-related migraine without aura group these effects were non-significant. These results indicate that the regulatory mechanisms in the central nervous system may differ between the two subtypes of migraine. The results provide novel insights into the pathophysiology of different subtypes of migraine, and could help us to enhance their clinical diagnosis and treatment.

Physiological determinants of biogeography: The importance of metabolic depression to heat tolerance - Ming‐ling Liao; Gao‐yang Li; Jie Wang; David J. Marshall; Tin Yan Hui; Shu‐yang Ma; Yi‐min Zhang; Brian Helmuth; Yun‐wei Dong (Global Change Biology, 2021)
A quantitative understanding of physiological thermal responses is vital for forecasting species distributional shifts in response to climate change. Many studies have focused on metabolic rate as a global metric for analyzing the sublethal effects of changing environments on physiology. Thermal performance curves (TPCs) have been suggested as a viable analytical framework, but standard TPCs may not fully capture physiological responses, due in part to failure to consider the process of metabolic depression. We derived a model based on the nonlinear regression of biological temperature‐dependent rate processes and built a heart rate data set for 26 species of intertidal molluscs distributed from 33°S to ~40°N. We then calculated physiological thermal performance limits with continuous heating using , the temperature at which heart rate is decreased to 50% of the maximal rate, as a more realistic measure of upper thermal limits. Results indicate that heat‐induced metabolic depression of cardiac performance is a common adaptive response that allows tolerance of harsh environments. Furthermore, our model accounted for the high inter‐individual variability in the shape of cardiac TPCs. We then used these TPCs to calculate physiological thermal safety margins (pTSM), the difference between the maximal operative temperature (95th percentile of field temperatures) and of each individual. Using pTSMs, we developed a physiological species distribution model (pSDM) to forecast future geographic distributions. pSDM results indicate that climate‐induced species range shifts are potentially less severe than predicted by a simple correlative SDM. Species with metabolic depression below the optimum temperature will be more thermal resistant at their warm trailing edges. High intraspecific variability further suggests that models based on species‐level vulnerability to environmental change may be problematic. This multi‐scale, mechanistic understanding that incorporates metabolic depression and inter‐individual variability in thermal response enables better predictions about the relationship between thermal stress and species distributions.

Importation of taxadiene synthase into chloroplast improves taxadiene production in tobacco - Jinqiu Fu; Wenbo Xu; Wei Huang; Bipeng Wang; Shengchun Li; Jiang Zhang; Ling Chang (Planta, 2021)

Resolvin D1 Attenuates Innate Immune Reactions in Experimental Subarachnoid Hemorrhage Rat Model - Guang-Jie Liu; Tao Tao; Xiang-Sheng Zhang; Yue Lu; Ling-Yun Wu; Yong-Yue Gao; Han Wang; Hai-Bin Dai; Yan Zhou; Zong Zhuang; Chun-Hua Hang; Wei Li (Molecular Neurobiology, 2021)

Genotoxicity Evaluation of Titanium Dioxide Nanoparticles In Vitro: a Systematic Review of the Literature and Meta-analysis - Chunmei Ling; Hongmei An; Li Li; Jiaqi Wang; Tianjiao Lu; Haixia Wang; Yunhua Hu; Guanling Song; Sixiu Liu (Biological Trace Element Research, 2021)

B3GNT3 acts as a carcinogenic factor in endometrial cancer via facilitating cell growth, invasion and migration through regulating RhoA/RAC1 pathway-associated markers - Ji-Shui Wang; Fang Ruan; Li-Zhu Guo; Feng-Ge Wang; Fu-Ling Wang; Hong-Min An (Genes & Genomics, 2021)

Effect of fermentation bed on bacterial growth in the fermentation mattress material and cecum of ducks - Jian- mei Wang; Xin- meng Gan; Fa-jun Pu; Wan- xia Wang; Min Ma; Ling-li Sun; Ji-wei Hu; Bo Hu; Rong-ping Zhang; Li-li Bai; Liang Li; He-he Liu (Archives of Microbiology, 2021)

The impact of biogenic emissions on ozone formation in the Yangtze River Delta region based on MEGANv3.1 - Yangjun Wang; Xingjian Tan; Ling Huang; Qian Wang; Hongli Li; Hongyan Zhang; Kun Zhang; Ziyi Liu; Dramane Traore; Elly Yaluk; Joshua S. Fu; Li Li (Air Quality, Atmosphere & Health, 2021)

Soil engineering by ants facilitates plant compensation for large herbivore removal of aboveground biomass - Zhiwei Zhong; Xiaofei Li; Dirk Sanders; Yiming Liu; Ling Wang; Yvette K. Ortega; Dean E. Pearson; Deli Wang (Ecology, 2021)
The interplay between top‐down and bottom‐up processes determines ecosystem productivity. Yet, the factors that mediate the balance between these opposing forces remain poorly understood. Furthering this challenge, complex and often cryptic factors like ecosystem engineering and trait‐mediated interactions may play major roles in mediating the outcomes of top‐down and bottom‐up interactions. In semiarid grasslands of northeastern China, we conducted a large‐scale, three‐year experiment to evaluate how soil engineering by ants and plasticity in plants independently and jointly influenced the top‐down effects of grazing by a ubiquitous herbivore (cattle) on aboveground standing biomass of the dominant perennial grass, Leymus chinensis . Herbivory had strong top‐down effects, reducing L. chinensis AB by 25% relative to baseline levels without cattle or ants. In contrast, soil engineering by ants facilitated weak bottom‐up effects in the absence of herbivory. However, in the presence of herbivory, soil engineering effects were strong enough to fully offset herbivore removal of aboveground biomass. This outcome was mediated by L. chinensis ’s plasticity in reallocating growth from below‐ to aboveground biomass, a result linked to additive effects of engineers and herbivores increasing soil N availability and engineering effects improving soil structure. Soil engineering increased soil N by 12%, promoting aboveground biomass. Herbivores increased soil N by 13% via defecation, but this increase failed to offset their reductions in aboveground biomass in isolation. However, when combined, engineers and herbivores increased soil N by 26% and engineers improved soil bulk density, facilitating L. chinensis to shift resource allocations from below‐ to aboveground biomass sufficiently to fully offset herbivore suppression of aboveground biomass. Our results demonstrate that soil engineering and trait‐mediated effects of plant plasticity can strongly mediate the outcome of top‐down and bottom‐up interactions. These cryptic but perhaps ubiquitous processes may help to explain the long‐debated phenomenon of plant compensatory responses to large grazers.

Effects of Co-Applications of Biochar and Solid Digestate on Enzyme Activities and Heavy Metals Bioavailability in Cd-Polluted Greenhouse Soil - Shuaixing Xue; Fengfen Chen; Yuying Wang; Zhijiang Shao; Congguang Zhang; Ling Qiu; Yi Ran; Li He (Water, Air, & Soil Pollution, 2021)

The Roles of Epinephelus coioides miR-122 in SGIV Infection and Replication - Hong-Yan Sun; Yu-Ling Su; Pin-Hong Li; Jia-Yang He; He-Jia Chen; Gang Wang; Shao-Wen Wang; Xiao-Hong Huang; You-Hua Huang; Qi-Wei Qin (Marine Biotechnology, 2021)
In mammals, mature miR-122 is 22 nucleotides long and can be involved in regulating a variety of physiological and biological pathways. In this study, the expression profile and effects of grouper Epinephelus coioides miR-122 response to Singapore grouper iridovirus (SGIV) infection were investigated. The sequences of mature microRNAs (miRNAs) from different organisms are highly conserved, and miR-122 from E. coioides exhibits high similarity to that from mammals and other fish. The expression of miR-122 was up-regulated during SGIV infection. Up-regulation of miR-122 could significantly enhance the cytopathic effects (CPE) induced by SGIV, the transcription levels of viral genes (MCP, VP19, LITAF and ICP18), and viral replication; reduce the expression of inflammatory factors (TNF-a, IL-6, and IL-8), and the activity of AP-1 and NF-κB, and miR-122 can bind the target gene p38α MAPK to regulate the SGIV-induced cell apoptosis and the protease activity of caspase-3. The results indicated that SGIV infection can up-regulate the expression of E. coioides miR-122, and up-regulation of miR-122 can affect the activation of inflammatory factors, the activity of AP-1 and NF-κB, and cell apoptosis to regulate viral replication and proliferation.

The prevalence and risks of major comorbidities among inpatients with pulmonary tuberculosis in China from a gender and age perspective: a large-scale multicenter observational study - Wanli Kang; Jian Du; Song Yang; Jiajia Yu; Hongyan Chen; Jianxiong Liu; Jinshan Ma; Mingwu Li; Jingmin Qin; Wei Shu; Peilan Zong; Yi Zhang; et al. (European Journal of Clinical Microbiology & Infectious Diseases, 2021)

Increased depression risk for elderly women with high blood levels of strontium and barium - Jia Lv; Yan-ling Li; Wen-qiang Ren; Rong Li; Jian-rong Chen; Chao Bao; Zhi-ping Du; Shun Feng; Ling Gu; Hui Gao; Kai-yong Liu; Lin-sheng Yang; et al. (Environmental Chemistry Letters, 2021)

Association Between Blood Heavy Metal Concentrations and Dyslipidemia in the Elderly - Xingmeng Zhu; Yong Fan; Jie Sheng; Ling Gu; Qi Tao; Rui Huang; Kaiyong Liu; Linsheng Yang; Guimei Chen; Hongjuan Cao; Kaichun Li; Fangbiao Tao; et al. (Biological Trace Element Research, 2021)

Activity evolution of landslides and debris flows after the Wenchuan earthquake in the Qipan catchment, Southwest China - Qing-yun Shi; Chuan Tang; Ling-feng Gong; Ming Chen; Ning Li; Wei Zhou; Jiang Xiong; Hai Tang; Xiao-di Wang; Ming-wei Li (Journal of Mountain Science, 2021)

Polymorphisms in the DC-SIGN gene and their association with the severity of hand, foot, and mouth disease caused by enterovirus 71 - Ya-Ping Li; Mu-Qi Wang; Chen-Rui Liu; Hui-Ling Deng; Yuan Wu; Shuang-Suo Dang; Li-Hong Xu (Archives of Virology, 2021)

Proteomic Analysis of Serum Differentially Expressed Proteins Between Allergic Bronchopulmonary Aspergillosis and Asthma - Hui Cai; Diquan Shuai; Xiaomin Xue; Yuqing Mo; Xixi Song; Ling Ye; Shuiming Li; Daiwei Wang; Yun Wang; Meiling Jin (Mycopathologia, 2021)

A novel porous silica-zirconia coating for improving bond performance of dental zirconia - Zhiwei Su; Mingxing Li; Ling Zhang; Chaoyang Wang; Leiqing Zhang; Jingqiu Xu; Baiping Fu (Journal of Zhejiang University-SCIENCE B, 2021)

A Fluorescent Visual Proton Donor and Photoacid Sterilant Based on Sulfonate‐conjugated BODIPY - Abbas Mohammed Ali; Jian Shao; Jia-Xin Wang; Qiu-Yun Chen; Yang Li; Ling-Ling Qu (Journal of Fluorescence, 2021)

Propylenella binzhouense gen. nov., sp. nov. isolated from activated sludge, and proposal of Propylenellaceae fam. nov. - Yu-Ling Liu; Dong Meng; Fang Wang; Xiao-Fan Gong; Peng-Fei Gu; Xiang-Yu Fan; Zong-Jun Du; Ji-Dong Zou; Qiang Li (Antonie van Leeuwenhoek, 2021)

Siccirubricoccus phaeus sp. nov., isolated from oil reservoir water and emended description of the genus Siccirubricoccus - Fang-Ling Li; Ya-Xi Zhang; Ya-Kun Zhang; Wen-Feng Chen; Wen-Jun Li; Lei Wang (Antonie van Leeuwenhoek, 2021)

Nickel carcinogenesis mechanism: cell cycle dysregulation - Hongrui Guo; Huidan Deng; Huan Liu; Zhijie Jian; Hengmin Cui; Jing Fang; Zhicai Zuo; Junliang Deng; Yinglun Li; Xun Wang; Ling Zhao (Environmental Science and Pollution Research, 2021)

miR-375-3p contributes to hypoxia-induced apoptosis by targeting forkhead box P1 (FOXP1) and Bcl2 like protein 2 (Bcl2l2) in rat cardiomyocyte h9c2 cells - Yuefan Li; Xiaofei Li; Ling Wang; Na Han; Gang Yin (Biotechnology Letters, 2021)

The Association Between Trace Elements Exposure and the Cognition in the Elderly in China - Ling Gu; Jinhui Yu; Yong Fan; Sufang Wang; Linsheng Yang; Kaiyong Liu; Qunan Wang; Guimei Chen; Dongmei Zhang; Ying Ma; Li Wang; Annuo Liu; et al. (Biological Trace Element Research, 2021)

Target-specific mutations efficiency at multiple loci of CRISPR/Cas9 system using one sgRNA in soybean - Ling Zhang; Yingzhe Wang; Tong Li; Hongmei Qiu; Zhengjun Xia; Yingshan Dong (Transgenic Research, 2021)

Comparative proteomic study on fem-1b in female and male gonads in Hyriopsis cumingii - Ya-Yu Wang; Sheng-Hua Duan; Sai-Sai Dong; Xiao-Yu Cui; Gui-Ling Wang; Jia-Le Li (Aquaculture International, 2021)

Sialic Acid Conjugate–Modified Liposomal Dexamethasone Palmitate Targeting Neutrophils for Rheumatoid Arthritis Therapy: Influence of Particle Size - Shuo Wang; Shuaishuai Yang; Xiaoxue Lai; Yanzhi Song; Ling Hu; Cong Li; Tao Shi; Xinrong Liu; Yihui Deng; Guoliang Chen (AAPS PharmSciTech, 2021)

Diterpenoid and triterpenoid glycosides from Clinopodium chinense - Ling-Xia Qu; Yong-Qiao Liu; Yang Wang; Hong Wang; Xue-Li Huang; Mei-Ling Zhang; Yong-Xiao Mou; Tun-Hai Xu; Yin-Di Zhu (Natural Product Research, 2021)

Design of the Blade under Low Flow Velocity for Horizontal Axis Tidal Current Turbine - Jun-Hua Chen; Xian-Cheng Wang; Hao Li; Chu-Hua Jiang; Ling-Jie Bao (Journal of Marine Science and Engineering, 2020)
The blade is the key component for energy capture in horizontal axis tidal current turbine, and the blade’s design is directly related to the efficiency of the power generation device. The seawater flow velocity is a crucial parameter for blade design. Since the seawater velocity changes constantly, it is extremely important to determine the design velocity of the blade. This article proposes a calculation method for the design velocity of the blade so that the designed blade can achieve better energy collection efficiency under a variable flow velocity. This study performed the following investigations: (1) The author tested and analyzed the seawater velocity variation at the experimental site, determining the designed flow velocity via calculations; (2) The author combined the blade element momentum and Wilson’s optimization design method using the MATLAB software to calculate the blade shape parameters and predict the performance under a number of different flow velocity forecasts; (3) When testing the device under sea conditions, the experimental results showed that the performance capture devices and digital projections are basically the same, which verifies the validity and effectiveness of the design method.

NAC103, a NAC family transcription factor, regulates ABA response during seed germination and seedling growth in Arabidopsis - Ling Sun; Li-Ping Liu; Ya-Zhen Wang; Lei Yang; Mei-Jing Wang; Jian-Xiang Liu (Planta, 2020)

Correction to: Involvement of proBDNF in Monocytes/Macrophages with Gastrointestinal Disorders in Depressive Mice - Yun-Qing Yu; Yan-Ling Zhang; Zhe Wang; Yu Liu; Hui Li; Chang-Qi Li; Xin-Fu Zhou; Zhao-Lan Hu; Ru-Ping Dai (Neurotoxicity Research, 2020)

Identification of Amino Acid Dysregulation as a Potential Biomarker for Autism Spectrum Disorder in China - Mingyang Zou; Dexin Li; Luxi Wang; Ling Li; Shu Xie; Yu Liu; Wei Xia; Caihong Sun; Lijie Wu (Neurotoxicity Research, 2020)

Involvement of proBDNF in Monocytes/Macrophages with Gastrointestinal Disorders in Depressive Mice - Yun-Qing Yu; Yan-Ling Zhang; Zhe Wang; Yu Liu; Hui Li; Xin-Fu Zhou; Zhao-Lan Hu; Ru-Ping Dai (Neurotoxicity Research, 2020)

Clinical characteristics and plasma antibody titer of patients with COVID-19 in Zhejiang, China - Wei-ling Xiang; Jing-jing Cheng; Lian-peng Wu; Bing-yu Chen; Wen-xin Li; Dan-ying Qiu; Wei Zhang; Fei-hang Ge; Dong Chen; Zhen Wang (Journal of Zhejiang University-SCIENCE B, 2020)

Silencing of DsbA-L gene impairs the PPARγ agonist function of improving insulin resistance in a high-glucose cell model - Xuan Zhou; Jia-qi Li; Li-jie Wei; Meng-zhou He; Jing Jia; Jing-yi Zhang; Shao-shuai Wang; Ling Feng (Journal of Zhejiang University-SCIENCE B, 2020)

α-Helical protein absorption at post-traumatic epileptic foci monitored by Fourier transform infrared mapping - Siyang Xiang; Dong Zhao; Hongxia Hao; Xu Wang; Ling Li; Tiantong Yang (Journal of Biosciences, 2020)

The extract of aquatic macrophyte Carex cinerascens induced colony formation in bloom-forming cyanobacterium Microcystis aeruginosa - Lin Li; Xiao-ling Jing; Ling Wang; Zhi-gao Zeng; Wen-hong Chen; Jia-hao Zhai; Si-qin Qi (Environmental Science and Pollution Research, 2020)

Examining the determinants of energy-related carbon emissions in Central Asia: country-level LMDI and EKC analysis during different phases - Fei Wang; Changjian Wang; Jing Chen; Zeng Li; Ling Li (Environment, Development and Sustainability, 2020)

Toxicity Changes of Heavily Polluted River Sediments on Daphnia magna Before and After Dredging - Li-Ling Zhang; Zhou-Tao Pei; Ya-Ni Zhao; Jing Zhang; Rou-Rou Xu; Meng Zhang; Wen-Qiang Wang; Li-Wei Sun; Guang-Can Zhu (Bulletin of Environmental Contamination and Toxicology, 2020)

Correction to: The H741D mutation in Tac1p contributes to the upregulation of CDR1 and CDR2 expression in Candida albicans - Jin-Yan Liu; Bing Wei; Ying Wang; Ce Shi; Wen-Jing Li; Yue Zhao; Ling-Ning Meng; Ming-Jie Xiang (Brazilian Journal of Microbiology, 2020)

The H741D mutation in Tac1p contributes to the upregulation of CDR1 and CDR2 expression in Candida albicans - Jin-Yan Liu; Bing Wei; Ying Wang; Ce Shi; Wen-Jing Li; Yue Zhao; Ling-Ning Meng; Ming-Jie Xiang (Brazilian Journal of Microbiology, 2020)

Patterns of intrinsic brain activity in essential tremor with resting tremor and tremor-dominant Parkinson’s disease - Jun-ying Li; Zhong-jiao Lu; Xue-ling Suo; Nan-nan Li; Du Lei; Ling Wang; Jia-xin Peng; Li-ren Duan; Jing Xi; Yi Jiang; Qi-yong Gong; Rong Peng (Brain Imaging and Behavior, 2020)

Inconsistency between cortical reorganization and functional connectivity alteration in the sensorimotor cortex following incomplete cervical spinal cord injury - Xuejing Li; Qian Chen; Weimin Zheng; Xin Chen; Ling Wang; Wen Qin; Kuncheng Li; Jie Lu; Nan Chen (Brain Imaging and Behavior, 2020)

Effect of freeze-thaw cycles on the physical and dynamic characteristic of modified Na-bentonite by KCl - Zhongnian Yang; Yuxue Cui; Guoyu Li; Xuesen Liu; Chunxiao Wang; Wei Shi; Xianzhang Ling (Arabian Journal of Geosciences, 2020)

Isotopic fingerprinting of dissolved iron sources in the deep western Pacific since the late Miocene - Ruolin Liu; Bai Guo; Maoyu Wang; Weiqiang Li; Tao Yang; Hongfei Ling; Tianyu Chen (Science China Earth Sciences, 2020)

Environmental perspectives of microplastic pollution in the aquatic environment: a review - Manzoor Ahmad; Jia-Ling Li; Pan-Deng Wang; Wael N. Hozzein; Wen-Jun Li (Marine Life Science & Technology, 2020)

Association of ADH7 Gene Polymorphism with Schizophrenia in the Han Population of Northern China: a Case-Control Study - Kuo Zeng; Ya Li; Meng Gao; Yong-ping Liu; Feng-ling Xu; Xi Xia; Jun Yao; Bao-jie Wang (Journal of Molecular Neuroscience, 2020)

Sleep deprivation aggravated lipopolysaccharide/d-galactosamine-induced acute liver injury by suppressing melatonin production - Lu Liu; Li Zhang; Longjiang Li; Mengting Chen; Zhe Wang; Yi Shen; Jiayi Huang; Ling Tang (Inflammation Research, 2020)

Removal of antipyrine through two-dimensional and three-dimensional electrolysis: comparison, modification, and improvement - Pengxiao Liu; Xu Wang; Jing Lu; Ying Li; Bin Hou; Ling Feng (Environmental Science and Pollution Research, 2020)

One-step icELISA developed with novel antibody for rapid and specific detection of diclazuril residue in animal-origin foods - Yanfang Zhang; Shufang Li; Tao Peng; Pimiao Zheng; Zile Wang; Zhuoren Ling; Haiyang Jiang (Food Additives & Contaminants: Part A, 2020)

Carbon and water fluxes and their coupling in an alpine meadow ecosystem on the northeastern Tibetan Plateau - Yuyang Wang; Yaoming Ma; Haixia Li; Ling Yuan (Theoretical and Applied Climatology, 2020)

An Experimental Study of Effect of High Temperature on the Permeability Evolution and Failure Response of Granite Under Triaxial Compression - Sheng-Qi Yang; Wen-Ling Tian; Derek Elsworth; Jian-Guo Wang; Li-Feng Fan (Rock Mechanics and Rock Engineering, 2020)

Identification of NCAPH as a biomarker for prognosis of breast cancer - Haotian Lu; Chunying Shi; Shuang Wang; Chaochao Yang; Xueqi Wan; Yunzhe Luo; Le Tian; Ling Li (Molecular Biology Reports, 2020)

The anti-inflammatory drug dimethyl itaconate protects against colitis-associated colorectal cancer - Qian Wang; Xin Ling Li; Yan Mei; Jia-Chong Ye; Wei Fan; Guang-Hui Cheng; Mu-Sheng Zeng; Guo-Kai Feng (Journal of Molecular Medicine, 2020)

Cloning and Characterization of a Ginsenoside-Hydrolyzing α-L-Arabinofuranosidase, CaAraf51, From Cellulosimicrobium aquatile Lyp51 - Sha-Sha Zuo; Yu-Chen Wang; Ling Zhu; Jiang-Yuan Zhao; Ming-Gang Li; Xiu-Lin Han; Meng-Liang Wen (Current Microbiology, 2020)

2D slope stability analysis based on Pan’s maximum principle - Xiao Gang Wang; Xing Chao Lin; Ping Sun; Xu Li; Yu Jie Wang; Yong Yu Ling (Bulletin of Engineering Geology and the Environment, 2020)

Sex Difference Between Trace Elements and Pulmonary Functions in Children - Zhenzhen Pan; Xiaojuan Zhang; Yu Hui; Hongxia Xiang; Qian Wang; Shiyao Xu; Ling Li (Biological Trace Element Research, 2020)

Comparison of mRNA Expression of P2X Receptor Subtypes in Different Arterial Tissues of Rats - Ling-Zhi Li; Li-Hui Yue; Zhi-Min Zhang; Jing Zhao; Lei-Ming Ren; Hong-Jie Wang; Lu Li (Biochemical Genetics, 2020)

CAS FGOALS-g3 Model Datasets for the CMIP6 Scenario Model Intercomparison Project (ScenarioMIP) - Ye Pu; Hongbo Liu; Ruojing Yan; Hao Yang; Kun Xia; Yiyuan Li; Li Dong; Lijuan Li; He Wang; Yan Nie; Mirong Song; Jinbo Xie; et al. (Advances in Atmospheric Sciences, 2020)
This paper describes the datasets from the Scenario Model Intercomparison Project (ScenarioMIP) simulation experiments run with the Chinese Academy of Sciences Flexible Global Ocean-Atmosphere-Land System Model, GridPoint version 3 (CAS FGOALS-g3). FGOALS-g3 is driven by eight shared socioeconomic pathways (SSPs) with different sets of future emission, concentration, and land-use scenarios. All Tier 1 and 2 experiments were carried out and were initialized using historical runs. A branch run method was used for the ensemble simulations. Model outputs were three-hourly, six-hourly, daily, and/or monthly mean values for the primary variables of the four component models. An evaluation and analysis of the simulations is also presented. The present results are expected to aid research into future climate change and socio-economic development.

Characterization of Arabidopsis thaliana Root-Related Mutants Reveals ABA Regulation of Plant Development and Drought Resistance - Huan Dong; Xiaonan Ma; Pei Zhang; Huan Wang; Xiaoli Li; Jiaxing Liu; Ling Bai; Chun-peng Song (Journal of Plant Growth Regulation, 2020)

RETRACTED ARTICLE: Knockdown of long non-coding RNA TUG1 depresses apoptosis of hippocampal neurons in Alzheimer’s disease by elevating microRNA-15a and repressing ROCK1 expression - Xia Li; Sheng-Wu Wang; Xi-Ling LI; Feng-Yuan Yu; Hai-Ming Cong (Inflammation Research, 2020)

The Therapeutic Effects of Magnolia Officinalis Extraction on an Antibiotics-Induced Intestinal Dysbacteriosis in Mice - Hui Tian; Ling Zhao; Qin Zhang; Yang Zhang; Xia Mao; Jian Wang; Tao Li; Jungang Li; Zhangqiang You; Qiping Ruan; Lichun Jiang (Current Microbiology, 2020)

Vitamin D receptor gene methylation in patients with hand, foot, and mouth disease caused by enterovirus 71 - Ya-Ping Li; Hui-Ling Deng; Wen-Jun Wang; Mu-Qi Wang; Mei Li; Yu-Feng Zhang; Jun Wang; Shuang-Suo Dang (Archives of Virology, 2020)

Production, safety, health effects and applications of diacylglycerol functional oil in food systems: a review - Yee-Ying Lee; Teck-Kim Tang; Eng-Tong Phuah; Chin-Ping Tan; Yong Wang; Ying Li; Ling-Zhi Cheong; Oi-Ming Lai (Critical Reviews in Food Science and Nutrition, 2020)

A potentially important resource: endophytic yeasts - Lijun Ling; Yixin Tu; Wenxia Ma; Shenglai Feng; Caiyun Yang; Yunhua Zhao; Nan Wang; Zibin Li; Lu Lu; Ji Zhang (World Journal of Microbiology and Biotechnology, 2020)

Physiological and transcriptomic analyses of brassinosteroid function in moso bamboo (Phyllostachys edulis) seedlings - Zhe Zhang; Xuelian Yang; Ling Cheng; Zejun Guo; Huiyuan Wang; Weihuang Wu; Kihye Shin; Jinyao Zhu; Xiaoli Zheng; Jianghu Bian; Yangchen Li; Lianfeng Gu; et al. (Planta, 2020)

Inhibitory efficacy of rapamycin against potato white mold - Seyedmohammadreza Ojaghian; Ling Wang; Li Wang (Journal of Plant Diseases and Protection, 2020)

Variation of biogeochemical cycle of riverine dissolved inorganic carbon and silicon with the cascade damming - Haojun Deng; Zhen Tao; Quanzhou Gao; Ling Yao; Yong Feng; Yinhua Li; Jian Ding; Zhengang Wang; Xiaoxi Lyu; Peng Xu (Environmental Science and Pollution Research, 2020)

Prenatal di-(2-ethylhexyl) phthalate maternal exposure impairs the spatial memory of adult mouse offspring in a phase- and gender-dependent manner - Ling-Li Zhao; Ru Shen; Cong-Cong Sun; Shan-Yu Zhang; Bo Wang; Mei-Fang Sun; De-Xiang Xu (Environmental Science and Pollution Research, 2020)

Cloning and expression of IGF-I, IGF-II, and GHR genes and the role of their single-nucleotide polymorphisms in the growth of pikeperch (Sander lucioperca) - Teng Teng; Xuqian Zhao; Caijuan Li; Jinqiang Guo; Yunfeng Wang; Chenglong Pan; Enguang Liu; Qufei Ling (Aquaculture International, 2020)

Methane Seeps and Independent Methane Plumes in the South China Sea Offshore Taiwan - Susan Mau; Tzu-Hsuan Tu; Marius Becker; Christian dos Santos Ferreira; Jhen-Nien Chen; Li-Hung Lin; Pei-Ling Wang; Saulwood Lin; Gerhard Bohrmann (Frontiers in Marine Science, 2020)

Association of Polygenic Risk Score with Age at Onset and Cerebrospinal Fluid Biomarkers of Alzheimer’s Disease in a Chinese Cohort - Wei-Wei Li; Zhen Wang; Dong-Yu Fan; Ying-Ying Shen; Dong-Wan Chen; Hui-Yun Li; Ling Li; Heng Yang; Yu-Hui Liu; Xian-Le Bu; Wang-Sheng Jin; Fan Zeng; et al. (Neuroscience Bulletin, 2020)

Improved robust tensor principal component analysis for accelerating dynamic MR imaging reconstruction - Mingfeng Jiang; Qiannan Shen; Yang Li; Xiaocheng Yang; Jucheng Zhang; Yaming Wang; Ling Xia (Medical & Biological Engineering & Computing, 2020)

Correction to: Intra-host diversity of hepatitis B virus during mother-to-child transmission: the X gene may play a key role in virus survival in children after transmission - Yanjie Li; Chenguang Shen; Liuqing Yang; Yang Yang; Miao Wang; Shanqin Li; Feng Chen; Min Yang; Ling Peng; Jinmin Ma; Zhongping Duan; Liqiang Li; et al. (Archives of Virology, 2020)

Genetic analysis and fine mapping of the gall midge resistance gene Gm5 in rice (Oryza sativa L.) - Hailian Zhou; Xinyi Wang; Yi Mo; Yang Li; Liuhui Yan; Zhihua Li; Wan Shu; Ling Cheng; Fengkuan Huang; Yongfu Qiu (Theoretical and Applied Genetics, 2020)

Genome-Wide Analysis of NAC Transcription Factors and Characterization of the Cold Stress Response in Sweet Osmanthus - Yuanzheng Yue; Ling Li; Yuli Li; Haiyan Li; Wenjie Ding; Tingting Shi; Gongwei Chen; Xiulian Yang; Lianggui Wang (Plant Molecular Biology Reporter, 2020)

Inhibition of miR-574-5p suppresses cell growth and metastasis and enhances chemosensitivity by targeting RNA binding protein QKI in cervical cancer cells - Rui Tong; Jingru Zhang; Chunyan Wang; Qian Li; Ling Wang; Mingxiu Ju (Naunyn-Schmiedeberg's Archives of Pharmacology, 2020)

Identification of PP2A and S6 Kinase as Modifiers of Leucine-Rich Repeat Kinase-Induced Neurotoxicity - Joan Poh Ling Sim; Wang Ziyin; Adeline Henry Basil; Shuping Lin; Zhongcan Chen; Chengwu Zhang; Li Zeng; Yu Cai; Kah-Leong Lim (NeuroMolecular Medicine, 2020)
Mutations in LRRK2 are currently recognized as the most common monogenetic cause of Parkinsonism. The elevation of kinase activity of LRRK2 that frequently accompanies its mutations is widely thought to contribute to its toxicity. Accordingly, many groups have developed LRRK2-specific kinase inhibitors as a potential therapeutic strategy. Given that protein phosphorylation is a reversible event, we sought to elucidate the phosphatase(s) that can reverse LRRK2-mediated phosphorylation, with the view that targeting this phosphatase(s) may similarly be beneficial. Using an unbiased RNAi phosphatase screen conducted in a Drosophila LRRK2 model, we identified PP2A as a genetic modulator of LRRK2-induced neurotoxicity. Further, we also identified ribosomal S6 kinase (S6K), a target of PP2A, as a novel regulator of LRRK2 function. Finally, we showed that modulation of PP2A or S6K activities ameliorates LRRK2-associated disease phenotype in Drosophila .

Short-term associations between ambient fine particulate matter pollution and hospital visits for chronic obstructive pulmonary disease in Yinzhou District, China - Cheng-yi Lin; Die Li; Jie-ming Lu; Zhe-bin Yu; Yao Zhu; Peng Shen; Meng-ling Tang; Ming-juan Jin; Hong-bo Lin; Li-ming Shui; Kun Chen; Jian-bing Wang (Environmental Science and Pollution Research, 2020)

Molecular evolution of GII.P17-GII.17 norovirus associated with sporadic acute gastroenteritis cases during 2013–2018 in Zhoushan Islands, China - Can Chen; Bing Wu; Hui Zhang; Ke-Feng Li; Rong Liu; Hong-Ling Wang; Jian-Bo Yan (Virus Genes, 2020)

Intra-host diversity of hepatitis B virus during mother-to-child transmission: the X gene may play a key role in virus survival in children after transmission - Yanjie Li; Chenguang Shen; Liuqing Yang; Yang Yang; Miao Wang; Shanqin Li; Feng Chen; Min Yang; Ling Peng; Jinmin Ma; Zhongping Duan; Liqiang Li; et al. (Archives of Virology, 2020)

Plastic pollution in croplands threatens long‐term food security - Dan Zhang; Ee Ling Ng; Wanli Hu; Hongyuan Wang; Pablo Galaviz; Hude Yang; Wentao Sun; Chongxiao Li; Xingwang Ma; Bin Fu; Peiyi Zhao; Fulin Zhang; et al. (Global Change Biology, 2020)
Plastic pollution is a global concern given its prevalence in aquatic and terrestrial ecosystems. Studies have been conducted on the distribution and impact of plastic pollution in marine ecosystems, but little is known on terrestrial ecosystems. Plastic mulch has been widely used to increase crop yields worldwide, yet the impact of plastic residues in cropland soils to soil health and crop production in the long term remained unclear. In this paper, using a global meta‐analysis, we found that the use of plastic mulch can indeed increase crop yields on average by 25%–42% in the immediate season due to the increase of soil temperature (+8%) and moisture (+17%). However, the unabated accumulation of film residues in the field negatively impacts its physicochemical properties linked to healthy soil and threatens food production in the long term. It has multiple negative impacts on plant growth including crop yield (at the mean rate of −3% for every additional 100 kg/ha of film residue), plant height (−2%) and root weight (−5%), and soil properties including soil water evaporation capacity (−2%), soil water infiltration rate (−8%), soil organic matter (−0.8%) and soil available phosphorus (−5%) based on meta‐regression. Using a nationwide field survey of China, the largest user of plastic mulch worldwide, we found that plastic residue accumulation in cropland soils has reached 550,800 tonnes, with an estimated 6%–10% reduction in cotton yield in some polluted sites based on current level of plastic residue content. Immediate actions should be taken to ensure the recovery of plastic film mulch and limit further increase in film residue loading to maintain the sustainability of these croplands.

Tracing mantle sources in the northern Lau back-arc basin by independent component analysis of basalt isotopic compositions - Xichang Wu; Liyan Tian; Xuan-Ce Wang; Fengyou Chu; Quanshu Yan; Fengyue Sun; Xiaohu Li; Wei Wang; Luyao Yu; Zhenggang Li; Ling Chen (International Geology Review, 2020)

Impacts of genomic research on soybean improvement in East Asia - Man-Wah Li; Zhili Wang; Bingjun Jiang; Akito Kaga; Fuk-Ling Wong; Guohong Zhang; Tianfu Han; Gyuhwa Chung; Henry Nguyen; Hon-Ming Lam (Theoretical and Applied Genetics, 2020)
It has been commonly accepted that soybean domestication originated in East Asia. Although East Asia has the historical merit in soybean production, the USA has become the top soybean producer in the world since 1950s. Following that, Brazil and Argentina have been the major soybean producers since 1970s and 1990s, respectively. China has once been the exporter of soybean to Japan before 1990s, yet she became a net soybean importer as Japan and the Republic of Korea do. Furthermore, the soybean yield per unit area in East Asia has stagnated during the past decade. To improve soybean production and enhance food security in these East Asian countries, much investment has been made, especially in the breeding of better performing soybean germplasms. As a result, China, Japan, and the Republic of Korea have become three important centers for soybean genomic research. With new technologies, the rate and precision of the identification of important genomic loci associated with desired traits from germplasm collections or mutants have increased significantly. Genome editing on soybean is also becoming more established. The year 2019 marked a new era for crop genome editing in the commercialization of the first genome-edited plant product, which is a high-oleic-acid soybean oil. In this review, we have summarized the latest developments in soybean breeding technologies and the remarkable progress in soybean breeding-related research in China, Japan, and the Republic of Korea.

Detection of serum IgM and IgG for COVID-19 diagnosis - Ling Zhong; Junlan Chuan; Bo Gong; Ping Shuai; Yu Zhou; Yi Zhang; Zhilin Jiang; Dingding Zhang; Xiaoqi Liu; Shi Ma; Yi Huang; He Lin; et al. (Science China Life Sciences, 2020)

Physiological and proteomic responses of mangrove plant Avicennia marina seedlings to simulated periodical inundation - Huan Li; Zan Li; Zhi-Jun Shen; Mei-Rong Luo; Yi-Ling Liu; Ming-Yue Wei; Wen-Hua Wang; Ying-Ying Qin; Chang-Hao Gao; Ke-Ke Li; Qian-Su Ding; Shan Zhang; et al. (Plant and Soil, 2020)

3D slope stability analysis method based on Pan’s maximum principle - Xiaogang Wang; Xinchao Lin; Xu Li; Ping Sun; Yongyu Ling (Landslides, 2020)

RNA-Seq revealed that infection with white tip nematodes could downregulate rice photosynthetic genes - Hong-Le Wang; Si-Hua Yang; Mei Lv; Shan-Wen Ding; Jun-Yi Li; Chun-Ling Xu; Hui Xie (Functional & Integrative Genomics, 2020)

Effects of carbon source addition on microbial community and water quality in recirculating aquaculture systems for Litopenaeus vannamei - Zhao Chen; Zhiqiang Chang; Long Zhang; Jiajia Wang; Ling Qiao; Xiefa Song; Jian Li (Fisheries Science, 2020)

Coix seed oil prolongs lifespan and enhances stress resistance in Caenorhabditis elegans - Xin-Yan Chen; De-Chun Liao; Ying-Ting Yu; Cong-Min Wei; Ling-Yan Xuan; Shan Li; Hong-Bing Wang (Biogerontology, 2020)

An Innovative Double-Layer Microsphere Used as Slow-Release Carbon Source for Biological Denitrification - Yunxiao Xing; Dan Zhang; Li Cai; Yifei Xie; Ling Wang; Qiulin Li; Yue Hua (Water, Air, & Soil Pollution, 2020)

Clinical and biochemical indexes from 2019-nCoV infected patients linked to viral loads and lung injury - Yingxia Liu; Yang Yang; Cong Zhang; Fengming Huang; Fuxiang Wang; Jing Yuan; Zhaoqin Wang; Jinxiu Li; Jianming Li; Cheng Feng; Zheng Zhang; Lifei Wang; et al. (Science China Life Sciences, 2020)

ABA and sucrose co-regulate strawberry fruit ripening and show inhibition of glycolysis - Ya Luo; Cong Ge; Yajie Ling; Fan Mo; Min Yang; Leiyu Jiang; Qing Chen; Yuanxiu Lin; Bo Sun; Yong Zhang; Yan Wang; Mengyao Li; et al. (Molecular Genetics and Genomics, 2020)

Identification of Differentially Expressed miRNAs in the Response of Spleen CD4+ T Cells to Electroacupuncture in Senescence-Accelerated Mice - Jianmin Liu; Jing Liu; Ling Xiao; Yawen Wang; Guangya Liu; Jia Li; Fengxia Liang (Cell Biochemistry and Biophysics, 2020)

The Jasmonic Acid Pathway Positively Regulates the Polyphenol Oxidase-Based Defense against Tea Geometrid Caterpillars in the Tea Plant (Camellia sinensis) - Jin Zhang; Xin Zhang; Meng Ye; Xi-Wang Li; Song-Bo Lin; Xiao-Ling Sun (Journal of Chemical Ecology, 2020)

Effects of amygdalin on type II collagen-induced arthritis in rats - Demei Luo; Qian Wang; Yan Meng; Ling Cao; Ning Feng; Wenjing Du; Huijun Li; Xunan Dong; Xiumin Ma; Li Luo (Biologia, 2020)

A recombinant infectious bronchitis virus from a chicken with a spike gene closely related to that of a turkey coronavirus - Yan Wang; Xuejiao Cui; Xu Chen; Shixing Yang; Yu Ling; Qianben Song; Su Zhu; Luying Sun; Chuang Li; Yu Li; Xutao Deng; Eric Delwart; et al. (Archives of Virology, 2020)

Utilization of pre-existing competent and barren quartz veins as hosts to later orogenic gold ores at Huangjindong gold deposit, Jiangnan Orogen, southern China - Liang Zhang; David I. Groves; Li-Qiang Yang; Si-Chen Sun; Roberto F. Weinberg; Jiu-Yi Wang; Sheng-Gang Wu; Lei Gao; Lan-Ling Yuan; Rong-Hua Li (Mineralium Deposita, 2020)

Regulation of Circadian Genes by the MAPK Pathway: Implications for Rapid Antidepressant Action - Xin-Ling Wang; Kai Yuan; Wen Zhang; Su-Xia Li; George Fu Gao; Lin Lu (Neuroscience Bulletin, 2020)

Fine mapping, candidate genes analysis, and characterization of a brown planthopper (Nilaparvata lugens Stål) resistance gene in the rice variety ARC5984 - Jiebin Lin; Xinyi Wang; Yang Li; Fanggui Bi; Ling Cheng; Fengkuang Huang; Rongbai Li; Yongfu Qiu (Euphytica, 2020)

Cytological, genetic, and proteomic analysis of a sesame (Sesamum indicum L.) mutant Siyl-1 with yellow–green leaf color - Tong-Mei Gao; Shuang-Ling Wei; Jing Chen; Yin Wu; Feng Li; Li-Bin Wei; Chun Li; Yan-Juan Zeng; Yuan Tian; Dong-Yong Wang; Hai-Yang Zhang (Genes & Genomics, 2020)
Background Both photosynthetic pigments and chloroplasts in plant leaf cells play an important role in deciding on the photosynthetic capacity and efficiency in plants. Systematical investigating the regulatory mechanism of chloroplast development and chlorophyll (Chl) content variation is necessary for clarifying the photosynthesis mechanism for crops. Objective This study aims to explore the critical regulatory mechanism of leaf color mutation in a yellow–green leaf sesame mutant Siyl - 1 . Methods We performed the genetic analysis of the yellow-green leaf color mutation using the F 2 population of the mutant Siyl - 1 . We compared the morphological structure of the chloroplasts, chlorophyll content of the three genotypes of the mutant F 2 progeny. We performed the two-dimensional gel electrophoresis (2-DE) and compared the protein expression variation between the mutant progeny and the wild type. Results Genetic analysis indicated that there were 3 phenotypes of the F 2 population of the mutant Siyl - 1 , i.e., YY type with light-yellow leaf color (lethal); Yy type with yellow-green leaf color, and yy type with normal green leaf color. The yellow-green mutation was controlled by an incompletely dominant nuclear gene, Siyl - 1 . Compared with the wild genotype, the chloroplast number and the morphological structure in YY and Yy mutant lines varied evidently. The chlorophyll content also significantly decreased ( P < 0.05 ). The 2-DE comparison showed that there were 98 differentially expressed proteins (DEPs) among YY, Yy, and yy lines. All the 98 DEPs were classified into 5 functional groups. Of which 82.7% DEPs proteins belonged to the photosynthesis and energy metabolism group. Conclusion The results revealed the genetic character of yellow-green leaf color mutant Siyl - 1 . 98 DEPs were found in YY and Yy mutant compared with the wild genotype. The regulation pathway related with the yellow leaf trait mutation in sesame was analyzed for the first time. The findings supplied the basic theoretical and gene basis for leaf color and chloroplast development mechanism in sesame.

Contribution of skeletal muscular glycine to rapid antidepressant effects of ketamine in an inflammation-induced mouse model of depression - Niannian Huang; Yue Wang; Gaofeng Zhan; Fan Yu; Shan Li; Dongyu Hua; Riyue Jiang; Shiyong Li; Yeshun Wu; Ling Yang; Bin Zhu; Fei Hua; et al. (Psychopharmacology, 2019)

Identification and Expression Pattern Analysis of Bacterial Blight Resistance Genes in Oryza officinalis Wall ex Watt Under Xanthomonas oryzae Pv. oryzae Stress - Chunmiao Jiang; Suqin Xiao; Dingqin Li; Ling Chen; Qiaofang Zhong; Fuyou Yin; Tengqiong Yu; Xue Ke; Dunyu Zhang; Jian Fu; Yue Chen; Bo Wang; et al. (Plant Molecular Biology Reporter, 2019)
Background Bacterial blight (BB) caused by Xanthomonas oryzae Pv. oryzae ( Xoo ) is one of the most serious diseases of rice worldwide. Oryza officinalis Wall ex Watt, harboring abundant genetic diversity and disease resistance features, are important resources of exploring resistance genes with broad-spectrum resistance to BB. However, the molecular mechanisms and genes of BB resistance in O. officinalis have been rarely explored. Results Here, the BB resistance of four different origin O. officinalis populations in Yunnan were identified by seven representative hypervirulent Xoo races, which exhibited different BB resistance among four populations, in which the BB resistance of the Gengma_Lincang population was the strongest. In addition, the pathogenetic ability of seven Xoo races to O. officinalis was different in that the pathogenicity of PXO99 was stronger than that of C5. There were no remarkable differences in leaf microstructures among four O. officinalis populations, revealing the differences in resistance of four O. officinalis to BB are caused by the endogenous resistance genes. Furthermore, our results proved that there were no nine cloned BB resistance genes in four populations but possessed dominant Xa5 , dominant Xa13 , and recessive xa3/xa26 homologous alleles of xa5 , xa13 , and Xa3 / Xa26 resistance genes. These three homologous genes were isolated and cloned from four populations and named OoXa5 , OoXa13 , and Ooxa3 / xa26 . The expression profile revealed that the expression levels of OoXa13 and Ooxa3/xa26 were significantly down-regulated under PXO99 and C5 stress, especially in the Gengma_Lincang population, suggesting the O. officinalis might enhance BB resistance by down-regulating the expression level of OoXa13 and Ooxa3 / xa26 . Conclusion The BB resistance genes of O. officinalis had its own characteristics by expression pattern and BLAST analysis of OoXa5 , OoXa13 , and Ooxa3 / xa26 , which indicated that there might be new genes or molecular mechanism of BB resistance in O. officinalis. Our studies provided a solid foundation and reference for revealing the molecular mechanism of BB resistance in O. officinalis .

Stabilization of hydrophobic organic contaminants in sediments by natural zeolites: bioavailability-based assessment of efficacy using equilibrium passive sampling - Yiqin Chen; Wenjian Yu; Ling Jin; Qian Wang; Jie Yin; Jianwei Lin; Juan-Ying Li (Journal of Soils and Sediments, 2019)

Multi‐model analysis of climate impacts on plant photosynthesis in China during 2000–2015 - Hao Yan; Shao‐Qiang Wang; Jun‐Bang Wang; Yun Cao; Ling‐Ling Xu; Men‐Xin Wu; Lu Cheng; Liu‐Xi Mao; Feng‐Hua Zhao; Xian‐Zhou Zhang; Yun‐Fen Liu; Yan‐Fen Wang; et al. (International Journal of Climatology, 2019)
Differences, arising from differences in gross primary production (GPP) model structures and driving forces, have fuelled arguments concerning interannual changes of GPP in China since 2000. To better investigate the interannual variability of GPP and its covariance with climate factors in China, this study adopted a multi‐model analysis based on three GPP models (i.e., Terrestrial Ecosystem Carbon flux model [TEC], Breathing Earth System Simulator model [BESS], and MOD17 GPP model). The results show that annual GPP in China increased by 0.021–0.057 Pg C year −1 from 2000 to 2015 attributable to atmospheric‐CO 2 fertilization effects and favourable climate change, that is, increasing precipitation ( P r ) and temperature ( T a ). However, northern China and southern China had a large difference in the amplitude of these GPP changes; annual GPP increased by 0.017–0.039 Pg C year −1 in northern China but only 0.001–0.018 Pg C year −1 in southern China. Northern China and southern China occupy contrasting climate zones and this contrast produced different interannual variability of GPP through different mechanisms. Northern China has a dry climate with GPP changes sensitive to P r . As a result, more P r along with higher T a in northern China produced the strong uptrend of GPP from 2000 to 2015. In contrast, southern China has a wet climate with its GPP sensitive to solar radiation and T a . For the interval of 2000–2015, decreasing radiation plus drought exerted a negative influence on GPP in southern China. This study highlights the diverse mechanisms in which climate change affects GPP in dry and wet climate zones. A robust multi‐model analysis is preferred to reduce uncertainties arising from a single GPP model and its driving data.

Switchable hydrophilicity solvent based and solidification-assisted liquid-phase microextraction combined with GFAAS for quantification of trace soluble lead in raw bovine and derivative milk products - Huili Wang; Min Xia; Yuhang Ling; Feiyue Qian; Jiaqi Xu; Zhenfeng Wang; Jieyi Li; Xuedong Wang (Food Additives & Contaminants: Part A, 2019)

Stress associated protein 1 regulates the development of glandular trichomes in Artemisia annua - Yuting Wang; Xueqing Fu; Lihui Xie; Wei Qin; Ling Li; Xiaofen Sun; Shihai Xing; Kexuan Tang (Plant Cell, Tissue and Organ Culture (PCTOC), 2019)