Bacteria and filamentous fungi running a relay race in Daqu fermentation enable macromolecular degradation and flavor substance formation - Wen-Hu Liu; Li-Juan Chai; Hong-Mei Wang; Zhen-Ming Lu; Xiao-Juan Zhang; Chen Xiao; Song-Tao Wang; Cai-Hong Shen; Jin-Song Shi; Zheng-Hong Xu (International Journal of Food Microbiology, 2023)

Comparison of two commercial methods with a UHPLC–MS/MS method for the determination of multiple mycotoxins in cereals - Ying-yue Zhang; Mei-juan Zhao; Chun-yao Liu; Kai Ma; Tian-yu Liu; Fei Chen; Li-na Wu; De-jun Hu; Guang-ping Lv (Food Chemistry, 2023)

Pickering high internal phase emulsions with excellent UV protection property stabilized by Spirulina protein isolate nanoparticles - Jingjing Ding; Yunxing Li; Qiubo Wang; Linqian Chen; Yi Mao; Jie Mei; Cheng Yang; Yajuan Sun (Food Hydrocolloids, 2023)

Chronic exposure to environmentally relevant concentrations of carbamazepine interferes with anxiety response of adult female zebrafish through GABA /5-HT pathway and HPI axis - Cheng-Ting Xie; Mei-Ling Tan; Ying-Wen Li; Qi-Liang Chen; Yan-Jun Shen; Zhi-Hao Liu (Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, 2023)

High dissolved oxygen exacerbates ammonia toxicity with sex-dependent manner in zebrafish - Sheng-Xiang Sun; Chun-Ting Hu; Fang Qiao; Li-Qiao Chen; Mei-Ling Zhang; Zhen-Yu Du (Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, 2023)

Click-crosslinked in-situ hydrogel improves the therapeutic effect in wound infections through antibacterial, antioxidant and anti-inflammatory activities - Xiong-Xin Lei; Chen-Yu Zou; Juan-Juan Hu; Yan-Lin Jiang; Xiu-Zhen Zhang; Long-Mei Zhao; Tao He; Qing-Yi Zhang; Ya-Xing Li; Jesse Li-Ling; Hui-Qi Xie (Chemical Engineering Journal, 2023)

Morphology controllable fabrication of arch-like covalent triazine framework nanosheets for high-rate and high energy density zinc-ion hybrid supercapacitors - Bei Liu; Ting Quan; Mei Yang; Yijiang Liu; Hongbiao Chen; Huaming Li (Chemical Engineering Journal, 2023)

Major and stably expressed QTL for traits related to the mature wheat embryo independent of kernel size - Surong Wang; Tianyu Wang; Qijing Xuan; Xiangru Qu; Qiang Xu; Qiantao Jiang; Zhien Pu; Yang Li; Yunfeng Jiang; Guoyue Chen; Mei Deng; Yanling Liu; et al. (Theoretical and Applied Genetics, 2023)

Identification of a suppressor for the wheat stripe rust resistance gene Yr81 in Chinese wheat landrace Dahongpao - Huiling Jin; Haipeng Zhang; Xuyang Zhao; Li Long; Fangnian Guan; Yunpeng Wang; Linyu Huang; Xiaoyue Zhang; Yuqi Wang; Hao Li; Wei Li; Zhien Pu; et al. (Theoretical and Applied Genetics, 2023)

In Vitro Antifungal Activity of Azoles and Other Antifungal Agents Against Pathogenic Yeasts from Vulvovaginal Candidiasis in China - Siyue Kan; Nana Song; Qiuyu Pang; Huan Mei; Hailin Zheng; Dongmei Li; Fan Cui; Guixia Lv; Ruifang An; Ping Li; Zhengai Xiong; Shangrong Fan; et al. (Mycopathologia, 2023)

Investigation of insecticidal activity of two Rhododendron species on stored-product insects - Yu-Li Sang; Lu Dai; Pei Wang; Li-Jiang Chen; Mei-Ling Jiao; Jing-Yu Liu; Nai-Zhi Zhang; Guang-Wen Fan; Yan-Jun Hao; Xiu-Lan Wang (Journal of Plant Diseases and Protection, 2023)

Production of MSTN knockout porcine cells using adenine base-editing-mediated exon skipping - Shuai-peng Yang; Xiang-xing Zhu; Zi-xiao Qu; Cai-yue Chen; Yao-bing Wu; Yue Wu; Zi-dan Luo; Xin-yi Wang; Chu-yu He; Jia-wen Fang; Ling-qi Wang; Guang-long Hong; et al. (In Vitro Cellular & Developmental Biology - Animal, 2023)

The interaction effects of biodegradable microplastics and Cd on Folsomia candida soil collembolan - Guoqiang Liu; Xuanzhu Gu; Jing Wu; Haidong Li; Lianghu Su; Mei Chen; Sujuan Chen; Yonghua Liu (Environmental Science and Pollution Research, 2023)

Single bubble probe atomic force microscope and impinging-jet technique unravel the interfacial interactions controlled by long chain fatty acid in anaerobic digestion - Jian-Lu Duan; Yi Han; Li-Juan Feng; Jing-Ya Ma; Xiao-Dong Sun; Xiao-Yu Liu; Fan-Shu Geng; Jia-Li Jiang; Mei-Yan Liu; Yu-Chen Sun; Pascal Peu; Bing-Jie Ni; et al. (Water Research, 2023)

Tectono-stratigraphic framework and evolution of East Junggar Basin, Central Asia - Xiaogang Li; Gang Chen; Chen Wu; Jie Li; Peter J. Haproff; Mei Geng; Shihu Wu; Shaohua Xu; Zhijun Li; Dan Yang (Tectonophysics, 2023)

Passive sampling of diverse pesticides in water by hydrophilic–lipophilic balance sorbent-embedded cellulose acetate membrane: Kinetics, equilibrium partitioning and field application - Xiaozhong Gao; Lei Qin; Shuangying Li; Liushan Jiang; Qingxiang Zhou; Yiping Xu; Mei Ma; Chunmao Chen (Science of The Total Environment, 2023)

Urinary concentrations of organophosphate esters in relation to semen quality: A cross-sectional study - Yaping Li; Dan Luo; Xiaoya Zhao; Han Wang; Zhiyi Zheng; Jun Liu; Chong Liu; Hui Wang; Yingjun Chen; Yinzhu Shang; Wenqing Lu; Surong Mei; et al. (Science of The Total Environment, 2023)

Dispersal limitation and host selection drive geo-specific and plant-specific differentiation of soil bacterial communities in the Tibetan alpine ecosystem - Sai Qu; Congcong Shen; Lin Zhang; Jichen Wang; Li-Mei Zhang; Baodong Chen; Guo-Xin Sun; Yuan Ge (Science of The Total Environment, 2023)

Self-forming electroactive dynamic membrane for enhancing the decolorization of methyl orange by weak electrical stimulation - Yang Yang; Jinning Wang; Mei Chen; Nan Li; Jiaguo Yan; Xin Wang (Science of The Total Environment, 2023)

Unveiling effect of iron on pyrolysis of bisphenol A epoxy by comparisons of product characteristics and reaction mechanisms - Hanlin Wang; Ziming Xu; Can Cheng; Teng Wang; Meng Mei; Si Chen; Jingxin Liu; Jinping Li (Process Safety and Environmental Protection, 2023)

Effect of antifreeze protein on the quality and microstructure of frozen chicken breasts - Junlin Chen; Yaqi Fan; Xingguo Zhang; Zimeng Yuan; Hairu Zhang; Xinglian Xu; Jun Qi; Guoyuan Xiong; Lin Mei; Yuan Zhu; Linwei Yang; Chao Li (Food Chemistry, 2023)

Residue behavior and risk assessment of afidopyropen and its metabolite M440I007 in tea - Mingming Guo; Hezhi Sun; Xinru Wang; Jiawei Yu; Fengjian Luo; Xinzhong Zhang; Mei Yang; Zhaoqun Li; Zongmao Chen; Li Zhou (Food Chemistry, 2023)

Aggregating-agent-assisted surface-enhanced Raman spectroscopy–based detection of acrylamide in fried foods: A case study with potato chips - Zhi-hao Ye; Xiao-tong Chen; Hai-yan Zhu; Xiao-qian Liu; Wen-hui Deng; Wei Song; Da-xiang Li; Ru-yan Hou; Hui-mei Cai; Chuan-yi Peng (Food Chemistry, 2023)

Revisiting the centrality definition and observable centrality dependence of relativistic heavy-ion collisions in PACIAE model - Yu-Liang Yan; Dai-Mei Zhou; An-Ke Lei; Xiao-Mei Li; Xiao-Ming Zhang; Liang Zheng; Gang Chen; Xu Cai; Ben-Hao Sa (Computer Physics Communications, 2023)

Dorsal root ganglia P2X4 and P2X7 receptors contribute to diabetes-induced hyperalgesia and the downregulation of electroacupuncture on P2X4 and P2X7 - Qun-qi Hu; Xiao-fen He; Yi-qi Ma; Li-qian Ma; Si-ying Qu; Han-zhi Wang; Yu-rong Kang; Lu-hang Chen; Xiang Li; Bo-yu Liu; Xiao-mei Shao; Jun-fan Fang; et al. (Purinergic Signalling, 2023)

Inhibition of phosphorylated calcium/calmodulin-dependent protein kinase IIα relieves streptozotocin-induced diabetic neuropathic pain through regulation of P2X3 receptor in dorsal root ganglia - Xiao-fen He; Yu-rong Kang; Xue-yu Fei; Lu-hang Chen; Xiang Li; Yi-qi Ma; Qun-qi Hu; Si-ying Qu; Han-zhi Wang; Xiao-mei Shao; Bo-yi Liu; Yi-Liang; et al. (Purinergic Signalling, 2023)
Diabetic neuropathic pain (DNP) is frequent among patients with diabetes. We previously showed that P2X3 upregulation in dorsal root ganglia (DRG) plays a role in streptozotocin (STZ)-induced DNP but the underlying mechanism is unclear. Here, a rat model of DNP was established by a single injection of STZ (65 mg/kg). Fasting blood glucose was significantly elevated from the 1 st to 3 rd week. Paw withdrawal thresholds (PWTs) and paw withdrawal latencies (PWLs) in diabetic rats significantly reduced from the 2 nd to 3 rd week. Western blot analysis revealed that elevated p-CaMKIIα levels in the DRG of DNP rats were accompanied by pain-associated behaviors while CaMKIIα levels were unchanged. Immunofluorescence revealed significant increase in the proportion of p-CaMKIIα immune positive DRG neurons (stained with NeuN) in the 2 nd and 3 rd week and p-CaMKIIα was co-expressed with P2X3 in DNP rats. KN93, a CaMKII antagonist, significantly reduce mechanical hyperalgesia and thermal hyperalgesia and these effects varied dose-dependently, and suppressed p-CaMKIIα and P2X3 upregulation in the DRGs of DNP rats. These results revealed that the p-CaMKIIα upregulation in DRG is involved in DNP, which possibly mediated P2X3 upregulation, indicating CaMKIIα may be an effective pharmacological target for DNP management.

Exploring the potential anti-Alzheimer disease mechanisms of Alpiniae Oxyphyliae Fructus by network pharmacology study and molecular docking - Rong-Rong Zhen; Yan-Jie Qu; Li-Min Zhang; Chao Gu; Min-Rui Ding; Lei Chen; Xiao Peng; Bing Hu; Hong-Mei An (Metabolic Brain Disease, 2023)

Feasibility assessment of heat pipe space reactor passive start-up without external neutron source - Chao Chen; Zhen Wang; Huaping Mei; Shuyong Liu; Meisheng He; Shichao Zhang; Taosheng Li (Annals of Nuclear Energy, 2023)

High cholesterol intake remodels cholesterol turnover and energy homeostasis in Nile tilapia (Oreochromis niloticus) - Rui-Xin Li; Ling-Yun Chen; Samwel M. Limbu; Yu-Cheng Qian; Wen-Hao Zhou; Li-Qiao Chen; Yuan Luo; Fang Qiao; Mei-Ling Zhang; Zhen-Yu Du (Marine Life Science & Technology, 2023)
The roles of dietary cholesterol in fish physiology are currently contradictory. The issue reflects the limited studies on the metabolic consequences of cholesterol intake in fish. The present study investigated the metabolic responses to high cholesterol intake in Nile tilapia ( Oreochromis niloticus ), which were fed with four cholesterol-contained diets (0.8, 1.6, 2.4 and 3.2%) and a control diet for eight weeks. All fish-fed cholesterol diets showed increased body weight, but accumulated cholesterol (the peak level was in the 1.6% cholesterol group). Then, we selected 1.6% cholesterol and control diets for further analysis. The high cholesterol diet impaired liver function and reduced mitochondria number in fish. Furthermore, high cholesterol intake triggered protective adaptation via (1) inhibiting endogenous cholesterol synthesis, (2) elevating the expression of genes related to cholesterol esterification and efflux, and (3) promoting chenodeoxycholic acid synthesis and efflux. Accordingly, high cholesterol intake reshaped the fish gut microbiome by increasing the abundance of Lactobacillus spp. and Mycobacterium spp., both of which are involved in cholesterol and/or bile acids catabolism. Moreover, high cholesterol intake inhibited lipid catabolic activities through mitochondrial β-oxidation, and lysosome-mediated lipophagy, and depressed insulin signaling sensitivity. Protein catabolism was elevated as a compulsory response to maintain energy homeostasis. Therefore, although high cholesterol intake promoted growth, it led to metabolic disorders in fish. For the first time, this study provides evidence for the systemic metabolic response to high cholesterol intake in fish. This knowledge contributes to an understanding of the metabolic syndromes caused by high cholesterol intake or deposition in fish.

Contaminant characterization at pesticide production sites in the Yangtze River Delta: Residue, distribution, and environmental risk - Mei Li; Qiang Chen; Lu Yang; Ya Zhang; Jinlin Jiang; Shaopo Deng; Jinzhong Wan; Tingting Fan; Tao Long; Shengtian Zhang; Yusuo Lin (Science of The Total Environment, 2023)

Heavy metal(loid)s in agricultural soil from main grain production regions of China: Bioaccessibility and health risks to humans - Cheng-Chen Wang; Qiao-Chu Zhang; Shao-Guo Kang; Meng-Ying Li; Meng-Yan Zhang; Wu-Mei Xu; Ping Xiang; Lena Q. Ma (Science of The Total Environment, 2023)

Eudesmane−type sesquiterpenes from the rhizomes of Atractylodes macrocephala and their bioactivities - Hai-Xin Zhang; Jin-Guang Si; Jing-Rong Li; Meng Yu; Ling-Ling Qin; Chen-Xu Zhao; Tao Zhang; Zhong-Mei Zou (Phytochemistry, 2023)

Two new tetrahydroisoquinoline alkaloids from Portulaca oleracea - Kai-Jun Tang; Yu Chen; Jing Li; Xu Tao; Lu-Ping Yang; Tian-Yun Jin; Jia-Shun Zhu; Yu Zhao; Tao Shen; Xiao-Ning Wang; Dong-Mei Ren; Lan Xiang (Phytochemistry Letters, 2023)

Four new glycosides from Gerbera piloselloides - Ha Gao; Chen-Xu Zhao; Xin-Yao Luo; Jing-Rong Li; Xiao-Chuan Ye; Tao Zhang; Zhong-Mei Zou (Phytochemistry Letters, 2023)

A new phragmalin-type limonoid from the roots of Trichilia sinensis - Shou-Bai Liu; Jin-Ling Yang; Hui-Qin Chen; Cheng-min Yang; Hao Wang; Cai-Hong Cai; Jing-Zhe Yuan; Wen-Li Mei; Hao-Fu Dai (Phytochemistry Letters, 2023)

Characterization of fibroblast growth factor receptor 4 (FGFR4) from the red swamp crayfish Procambarus clarkii and its role in antiviral and antimicrobial immune responses - Yan-Mei Zhang; Chen-Yang Lin; Bang-Ze Li; Wen-Bin Xu; Wei-Ren Dong; Miao-An Shu (Journal of Invertebrate Pathology, 2023)

Detection of polycyclic aromatic hydrocarbons using a high performance-single particle aerosol mass spectrometer - Yao Zhang; Chenglei Pei; Jinwen Zhang; Chunlei Cheng; Xiufeng Lian; Mubai Chen; Bo Huang; Zhong Fu; Zhen Zhou; Mei Li (Journal of Environmental Sciences, 2023)

Associations between maternal phthalate exposure and neonatal neurobehaviors: The Taiwan maternal and infant cohort study (TMICS) - Hsing-Kang Chen; Shu-Li Wang; Yu-Hsun Chang; Chien-Wen Sun; Ming-Tsang Wu; Mei-Lien Chen; Yu-Jie Lin; Chia-Jung Hsieh (Environmental Pollution, 2023)

Photoactivatable metal organic framework for synergistic ferroptosis and photodynamic therapy using 450 nm laser - Yuhang Chen; Lijiang Gu; Bohan Ma; Xing Li; Yibo Mei; Jinlai Zhou; Yue Chong; Minghai Ma; Mengzhao Zhang; Lu Wang; Yifan Cheng; Kaijie Wu; et al. (Chemical Engineering Journal, 2023)

Plastome evolution and phylogenomics of Impatiens (Balsaminaceae) - He Qiu; Zhi-Hui Zhang; Mei-Zhen Wang; Xin-Jie Jin; Jie-Dong Lin; Hans Peter Comes; Jing-Xuan Chen; Rui-Ning Cui; Ru-Qing Duan; Pan Li (Planta, 2023)

Report on the 3rd Board Meeting of the International Human Phenome Consortium - Mei Tian; Han Liu; Shunling Chen; Zhong Yang; Weishuo Tao; Shiwen Peng; Huiting Che; Li Jin (Phenomics, 2023)

Uplift history of the Northern Tianshan constrained from the inversion of river profiles - Runing Hou; Mei Liu; Ningsheng Chen; MingFeng Deng; Shufeng Tian; Yujia Li; Huayong Ni; Zheng Han (International Journal of Earth Sciences, 2023)

A lightweight detection method for the spatial distribution of underwater fish school quantification in intensive aquaculture - Yingyi Chen; Huihui Liu; Ling Yang; Huihui Yu; Daoliang Li; Siyuan Mei; Yeqi Liu (Aquaculture International, 2023)

Retraction Note: Cancer-derived exosomal miR-221-3p promotes angiogenesis by targeting THBS2 in cervical squamous cell carcinoma - Xiang-Guang Wu; Chen-Fei Zhou; Yan-Mei Zhang; Rui-Ming Yan; Wen-Fei Wei; Xiao-Jing Chen; Hong-Yan Yi; Luo-Jiao Liang; Liang-sheng Fan; Li Liang; Sha Wu; Wei Wang (Angiogenesis, 2023)

Prenatal titanium exposure and child neurodevelopment at 1 year of age: A longitudinal prospective birth cohort study - Yangqian Jiang; Yongyue Wei; Wenhui Guo; Jiangbo Du; Tao Jiang; Hongxia Ma; Guangfu Jin; Ting Chen; Rui Qin; Shiyao Tao; Qun Lu; Hong Lv; et al. (Chemosphere, 2023)

Effect of hydrodynamics on the transformation of nitrogen in river water by regulating the mass transfer performance of dissolved oxygen in biofilm - Mei Pan; Haizong Li; Xiangyun Han; Guixiang Quan; Weixing Ma; Qingyuan Guo; Xuan Li; Bairen Yang; Cheng Ding; Yuxi Chen; Tao Yun; Jiaojiao Qin; et al. (Chemosphere, 2023)

Co-exposure to phenols and phthalates during pregnancy with the difference of body size in twins at one month old - Hong Mei; Langjing Deng; Jinying Xie; Xiaojie Li; Nanxin Wu; Liqin Hu; Guangtong Huang; Fanyu Mo; Da Chen; Han Xiao; Pan Yang (Chemosphere, 2023)

Metabolism of linoleic and linolenic acids in muscle cells of two freshwater fish with n-3 or n-6 fatty acid requirements - Yuan Luo; Jian-Gang Jiao; An-Hui Jin; Dilawar Hussain; Li-Qiao Chen; Fang Qiao; Mei-Ling Zhang; Zhen-Yu Du (Aquaculture, 2023)

Comparative transcriptome analysis of early sexual differentiation in the male and female gonads of common carp (Cyprinus carpio) - Mei Wang; Lin Chen; Zhixiong Zhou; Junzhu Xiao; Baohua Chen; Peihong Huang; Chengyu Li; Yaguo Xue; Ruoting Liu; Yulin Bai; Mengzhen Yan; Shuimu Hu; et al. (Aquaculture, 2023)

Residue depletion of danofloxacin in Yellow River carp (Cyprinus carpio haematopterus) following multiple oral administration - Zhe-Wen Song; Fang Yang; Yue Liu; Hao-Tian Shao; Mei Zhang; Jun-Cheng Chen; Kai-Li Ma; Fan Yang (Aquaculture, 2023)

Human CYP1B1 enzyme-mediated, AhR enhanced activation of aflatoxin B1 for its genotoxicity in human cells - Yuting Chen; Zhaohong Lu; Boxin Li; Huanhuan Wang; Tikeng Jiang; Mei Xuan; Hui Yang; Jialong Chen; Xiaoshan Liu; Hairong Liang; Yungang Liu; Huanwen Tang (Toxicology Letters, 2023)

Changes in arsenic accumulation and metabolic capacity after environmental management measures in mining area - Chen Zhao; Meng Du; Jun Yang; Guanghui Guo; Lingqing Wang; Yunxian Yan; Xuewen Li; Mei Lei; Tongbin Chen (Science of The Total Environment, 2023)

Real-world characterization of carbonaceous substances from industrial stationary and process source emissions - Min Cui; Yuanyuan Xu; Fan Zhang; Caiqing Yan; Jun Li; Mei Zheng; Yingjun Chen (Science of The Total Environment, 2023)

Undescribed isoquinolines from Zanthoxylum nitidum and their antiproliferative effects against human cancer cell lines - Feng Qin; Cai Yi Wang; Chun-Gu Wang; Yao Chen; Jin-Jun Li; Mei-Shan Li; Yan-Kui Zhu; Sang Kook Lee; Heng-Shan Wang (Phytochemistry, 2023)

Controlling methane emissions from Integrated Vertical-Flow Constructed Wetlands by using potassium peroxymonosulfate as oxidant - Xinping Li; Xiaoling Liu; Ke Zhang; Hongbing Luo; Aiping Pu; Daiwei Zhuang; Bing Jiang; Mei Li; Wei Chen; Liangqian Fan; Jing Qing; Xiaoxiao Zhang; et al. (Journal of Environmental Management, 2023)

Thermodynamic characteristics of methane hydrate formation in high-pressure microcalorimeter under different reaction kinetics - Juan Fu; Jia-Mei Mo; Shi-Jun Liu; Wen-Zhe Yi; Yi-Song Yu; Neng-You Wu; Xiao-Li Chen; Qiu-Cheng Su; Xiao-Sen Li (Fuel, 2023)

Association of long-term air pollution exposure with the risk of prediabetes and diabetes: Systematic perspective from inflammatory mechanisms, glucose homeostasis pathway to preventive strategies - Yayuan Mei; Ang Li; Jiaxin Zhao; Quan Zhou; Meiduo Zhao; Jing Xu; Runkui Li; Yanbing Li; Kai Li; Xiaoyu Ge; Chen Guo; Yongjie Wei; et al. (Environmental Research, 2023)

Bioaccumulation of Cd and comparative transcriptome analysis after the antagonism of Se in the hepatopancreas of estuary mud crab (Scylla paramamosain) - Yan-Mei Zhang; Chen-Yang Lin; Bang-Ze Li; Wei-Ren Dong; Miao-An Shu (Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, 2023)

Characterization of carbonaceous matter emitted from residential coal and biomass combustion by experimental simulation - Min Cui; Yuanyuan Xu; Binbin Yu; Caiqing Yan; Jun Li; Mei Zheng; Yingjun Chen (Atmospheric Environment, 2023)

Annual methane uptake of an artificial grassland under different grazing strategies - Shuai Li; Peng Chen; Baoling Mei; Hongyu Yue; Xunhua Zheng; Gaojie Ren; Aruhan; Suhe (Nutrient Cycling in Agroecosystems, 2023)

The Nucleus Accumbens CRH–CRHR1 System Mediates Early-Life Stress-Induced Sleep Disturbance and Dendritic Atrophy in the Adult Mouse - Ting Wang; Yu-Nu Ma; Chen-Chen Zhang; Xiao Liu; Ya-Xin Sun; Hong-Li Wang; Han Wang; Yu-Heng Zhong; Yun-Ai Su; Ji-Tao Li; Tian-Mei Si (Neuroscience Bulletin, 2023)

Andrographolide ameliorates hepatic steatosis by suppressing FATP2-mediated fatty acid uptake in mice with nonalcoholic fatty liver disease - Li-Sha Ran; Ya-Zeng Wu; Yi-Wen Gan; Hong-Lian Wang; Li-Juan Wu; Chun-Mei Zheng; Yao Ming; Ran Xiong; Yong-Lin Li; Shi-Hang Lei; Xue Wang; Xiao-Qing Lao; et al. (Journal of Natural Medicines, 2023)
Excessive intrahepatocellular lipid accumulation or steatosis is caused by abnormal lipid metabolism and a common character of nonalcoholic fatty liver disease (NAFLD), which may progress into cirrhosis and hepatocellular cancer. Andrographolide (Andro) is the primary active ingredient extracted from Andrographis paniculata , showing a protective role against dietary steatosis with the mechanism not fully understood. In this study, we showed that administration of Andro (50, 100, and 200 mg/kg/day for 8 weeks, respectively) attenuated obesity and metabolic syndrome in high-fat diet (HFD)-fed mice with improved glucose tolerance, insulin sensitivity, and reduced hyperinsulinemia, hyperglycemia, and hyperlipidemia. HFD-fed mice presented hepatic steatosis, which was significantly prevented by Andro. In vitro, Andro decreased the intracellular lipid droplets in oleic acid-treated LO2 cells. The selected RT-PCR array revealed a robust expression suppression of the fatty acid transport proteins (FATPs) by Andro treatment. Most importantly, we found that Andro consistently reduced the expression of FATP2 in both the oleic acid-treated LO2 cells and liver tissues of HFD-fed mice. Overexpression of FATP2 abolished the lipid-lowering effect of Andro in oleic acid-treated LO2 cells. Andro treatment also reduced the fatty acid uptake in oleic acid-treated LO2 cells, which was blunted by FATP2 overexpression. Collectively, our findings reveal a novel mechanism underlying the anti-steatosis effect of Andro by suppressing FATP2-mediated fatty acid uptake, suggesting the potential therapeutic application of Andro in the treatment of NAFLD. Graphical abstract

Acinetobacter faecalis Sp. Nov., Isolated from Elephant Faeces - Xue-Mei Chen; De-Feng An; Si-Rong He; Shao-Juan Yang; Zu-Zhen Yang; Lian-Shuang Xiong; Gui-Ding Li; Ming-Guo Jiang; Cheng-Lin Jiang; Yi Jiang (Current Microbiology, 2023)

Three-fluorescence sensor for minute-time scale low-cost analysis of urinary oxalate in urolithiasis metabolic assessment - Xin Jiang; Yunjin Bai; Qilin Liu; Li Yan; Tingting Long; Mei Li; Jin Huang; Binwu Ying; Piaopiao Chen (Analytica Chimica Acta, 2023)

Selenium attenuates the association of co-exposure to arsenic, cadmium, and lead with cognitive function among Chinese community-dwelling older adults - Bei-Jing Cheng; Jie Sheng; Hong-Li Wang; Yuan Wang; Hong-Juan Cao; Xiu-De Li; Ting-Ting Zhou; Xiang-Long Meng; Huan-Huan Nie; Su-Fang Wang; Dong-Mei Zhang; Gui-Mei Chen; et al. (Environmental Science and Pollution Research, 2022)

Scaling-up and proteomic analysis reveals photosynthetic and metabolic insights toward prolonged H2 photoproduction in Chlamydomonas hpm91 mutant lacking proton gradient regulation 5 (PGR5) - Peng Liu; De-Min Ye; Mei Chen; Jin Zhang; Xia-He Huang; Li-Li Shen; Ke-Ke Xia; Xiao-Jing Xu; Yong-Chao Xu; Ya-Long Guo; Ying-Chun Wang; Fang Huang (Photosynthesis Research, 2022)
Clean and sustainable H 2 production is crucial to a carbon–neutral world. H 2 generation by Chlamydomonas reinhardtii is an attractive approach for solar-H 2 from H 2 O. However, it is currently not large-scalable because of lacking desirable strains with both optimal H 2 productivity and sufficient knowledge of underlying molecular mechanism. We hereby carried out extensive and in-depth investigations of H 2 photoproduction of hpm91 mutant lacking PGR5 (Proton Gradient Regulation 5) toward its up-scaling and fundamental mechanism issues. We show that hpm91 is at least 100-fold scalable (up to 10 L) with continuous H 2 collection of 7287 ml H 2 /10L-HPBR in averagely 26 days under sulfur deprivation. Also, we show that hpm91 is robust and active during sustained H 2 photoproduction, most likely due to decreased intracellular ROS relative to wild type. Moreover, we obtained quantitative proteomic profiles of wild type and hpm91 at four representing time points of H 2 evolution, leading to 2229 and 1350 differentially expressed proteins, respectively. Compared to wild type, major proteome alterations of hpm91 include not only core subunits of photosystems and those related to anti-oxidative responses but also essential proteins in photosynthetic antenna, C/N metabolic balance, and sulfur assimilation toward both cysteine biosynthesis and sulfation of metabolites during sulfur-deprived H 2 production. These results reveal not only new insights of cellular and molecular basis of enhanced H 2 production in hpm91 but also provide additional candidate gene targets and modules for further genetic modifications and/or in artificial photosynthesis mimics toward basic and applied research aiming at advancing solar-H 2 technology.

A Fundamental Role of Slope Aspect and Elevation in Controlling Diversity Patterns of Soil Bacterial Communities: Insights from an Arid-Montane Ecosystem in China - Long-Fei Chen; Jun-Qia Kong; Zhi-Bin He; Wen-Zhi Zhao; Ming-Dan Song; Yue-Mei Li; Yuan Gao; Shu-Ping Yang (Journal of Soil Science and Plant Nutrition, 2022)

Copper Toxicity Differentially Regulates the Seedling Growth, Copper Distribution, and Photosynthetic Performance of Citrus sinensis and Citrus grandis - Xin-yu Li; Mei-lan Lin; Ping-ping Hu; Ning-wei Lai; Zeng-rong Huang; Li-song Chen (Journal of Plant Growth Regulation, 2022)

The association between essential trace element mixture and atherosclerotic cardiovascular disease risk among Chinese community-dwelling older adults - Xiang-long Meng; Yuan Wang; Hong-li Wang; Huan-huan Nie; Bei-jing Cheng; Hong-juan Cao; Xiu-de Li; Su-fang Wang; Gui-mei Chen; Fang-biao Tao; Jie Sheng; Lin-sheng Yang (Environmental Science and Pollution Research, 2022)

Abundant and diverse endophytic bacteria associated with medicinal plant Arctium lappa L. and their potential for host plant growth promoting - Jia-Qi Liu; Shu-Mei Chen; Chun-Mei Zhang; Ming-Jie Xu; Ke Xing; Cheng-Guo Li; Kui Li; Yu-Qin Zhang; Sheng Qin (Antonie van Leeuwenhoek, 2022)

The cAMP‐PKA signalling pathway regulates hyphal growth, conidiation, trap morphogenesis, stress tolerance, and autophagy in Arthrobotrys oligospora - Mei‐Chen Zhu; Na Zhao; Yan‐Kun Liu; Xue‐Mei Li; Zheng‐Yi Zhen; Ya‐Qing Zheng; Ke‐Qin Zhang; Jin‐Kui Yang (Environmental Microbiology, 2022)
The cyclic adenosine monophosphate‐protein kinase A (cAMP‐PKA) signalling pathway is evolutionarily conserved in eukaryotes and plays a crucial role in defending against external environmental challenges, which can modulate the cellular response to external stimuli. Arthrobotrys oligospora is a typical nematode‐trapping fungus that specializes in adhesive networks to kill nematodes. To elucidate the biological roles of the cAMP‐PKA signalling pathway, we characterized the orthologous adenylate cyclase AoAcy, a regulatory subunit (AoPkaR), and two catalytic subunits (AoPkaC1 and AoPkaC2) of PKA in A. oligospora by gene disruption, transcriptome, and metabolome analyses. Deletion of Aoacy significantly reduced the levels of cAMP and arthrobotrisins. Results revealed that Aoacy , AopkaR , and AopkaC1 were involved in hyphal growth, trap morphogenesis, sporulation, stress resistance, and autophagy. In addition, Aoacy and AopkaC1 were involved in the regulation of mitochondrial morphology, thereby affecting energy metabolism, whereas AopkaC2 affected sporulation, nuclei, and autophagy. Multi‐omics results showed that the cAMP‐PKA signalling pathway regulated multiple metabolic and cellular processes. Collectively, these data highlight the indispensable role of cAMP‐PKA signalling pathway in the growth, development, and pathogenicity of A. oligospora, and provide insights into the regulatory mechanisms of signalling pathways in sporulation, trap formation, and lifestyle transition.

Synthesis and biological evaluation of (+)-paeoveitol derivatives as novel antidepressants - Tian-Ze Li; Xiao-Yan Huang; Jin-Jin Sun; Chang-An Geng; Xue-Mei Zhang; Ji-Jun Chen (Medicinal Chemistry Research, 2022)

Effects of rainfall and rocky desertification on soil erosion in karst area of Southwest China - Li-dong Pan; Rui Li; Dong-cai Shu; Li-na Zhao; Mei Chen; Jun Jing (Journal of Mountain Science, 2022)

Genetic variations in the bitter taste receptor gene TAS2R38 are related to cigarette smoking behavior in Han Chinese smokers - Fei-Yan Qi; Zhou-Hai Zhu; Meng Li; Ying Guan; Qi-Yuan Peng; She-Ming Lu; Zhi-Hua Liu; Ming-Feng Wang; Ming-Ming Miao; Zhang-Yu Chen; Xue-Mei Li; Jie Bai; et al. (Genes & Genomics, 2022)

Complete chloroplast genomes of two medicinal Swertia species: the comparative evolutionary analysis of Swertia genus in the Gentianaceae family - Qing Du; Jing Li; Liqiang Wang; Haimei Chen; Mei Jiang; Zhuoer Chen; Chuanbei Jiang; Haidong Gao; Bin Wang; Chang Liu (Planta, 2022)

Clinical profiles and antimicrobial resistance patterns of invasive Salmonella infections in children in China - Wen Song; Qingwen Shan; Yue Qiu; Xianyao Lin; Chunhui Zhu; Zhiqiang Zhuo; Caihong Wang; Jianning Tong; Rui Li; Chaomin Wan; Yu Zhu; Minxia Chen; et al. (European Journal of Clinical Microbiology & Infectious Diseases, 2022)
Invasive Salmonella infections result in a significant burden of disease including morbidity, mortality, and financial cost in many countries. Besides typhoid fever, the clinical impact of non-typhoid Salmonella infections is increasingly recognized with the improvement of laboratory detection capacity and techniques. A retrospective multicenter study was conducted to analyze the clinical profiles and antimicrobial resistance patterns of invasive Salmonella infections in hospitalized children in China during 2016–2018. A total of 130 children with invasive Salmonella infections were included with the median age of 12 months (range: 1–144 months). Seventy-nine percent of cases occurred between May and October. Pneumonia was the most common comorbidity in 33 (25.4%) patients. Meningitis and septic arthritis caused by nontyphoidal Salmonella (NTS) infections occurred in 12 (9.2%) patients and 5 (3.8%) patients. Patients < 12 months (OR: 16.04) and with septic shock (OR: 23.4), vomit (OR: 13.33), convulsion (OR: 15.86), C-reactive protein (CRP) ≥ 40 g/L (OR: 5.56), and a higher level of procalcitonin (PCT) (OR: 1.05) on admission were statistically associated to an increased risk of developing meningitis. Compared to 114 patients with NTS infections , 16 patients with typhoid fever presented with higher levels of CRP and PCT ( P < 0.05). The rates of resistance to ampicillin, sulfamethoxazole/trimethoprim, ciprofloxacin, and ceftriaxone among Salmonella Typhi and NTS isolates were 50% vs 57.3%, 9.1% vs 24.8%, 0% vs 11.2%, and 0% vs 9.9%, respectively. NTS has been the major cause of invasive Salmonella infections in Chinese children and can result in severe diseases. Antimicrobial resistance among NTS was more common.

Responses of submerged macrophyte Ceratophyllum demersum to the gradient concentrations of microcystin-LR (MC-LR) - Jing Dong; Dujuan Dai; Yue Yang; Feihu Wang; Xuejun Li; Jie Yuan; Yuhuan Chen; Yunni Gao; Man Zhang; Xiaofei Gao; Mei Li; Jingxiao Zhang (Environmental Science and Pollution Research, 2022)

Antibacterial activities of the chemical constituents of Schizophyllum commune MST7-3 collected from coal area - Guang-Gui Chen; Qin-Feng Zhu; Xing-Mei Long; Qian Lu; Kai-Yu Li; Qian Chen; Meng Zhou; Shang-Gao Liao; Guo-Bo Xu (Natural Product Research, 2022)

Cassane diterpenoids from Caesalpinia pulcherrima and their anti-inflammatory and α -glycosidase inhibitory activities - Xin Yun; Xiu-Mei Chen; Jia-Yun Wang; Wang Lu; Zi-Han Zhang; Young Ho Kim; Shi-Chun Zong; Chun-Huan Li; Jin-Ming Gao (Natural Product Research, 2022)

A real-time passive acoustic monitoring system to detect Yangtze finless porpoise clicks in Ganjiang River, China - Weilun Li; Jiansong Qiu; Peiyu Lei; Xiaohong Chen; Fei Fan; Xiaojun Deng; Yingen Dai; Yanqing Deng; Kexiong Wang; Zhigang Mei (Frontiers in Marine Science, 2022)
Phocoenidae live in fresh, coastal waters where they often share a significant portion of their habitat with humans. As a result, local activities (e.g., coastal fisheries and shipments) cause underwater noise pollution and threaten their ecosystem. To better conserve the habitat of porpoises, we aimed to study their activities in these waters by recording their echolocation clicks using a passive acoustic monitoring (PAM) system. However, because the off-line PAM instruments were often used in the past that need to be periodically deployed and recovered, data acquisition is typically obtained and analyzed in batches, rather than in real-time. A real-time PAM detection system would help minimize the impact of underwater noise on approaching porpoises. Furthermore, issues of bad quality data–with gaps due to loss or damage of the off-line PAM instruments–could be avoided with a real-time detection system. Therefore, in this study, we developed the Real-time Porpoise Click Detector-II (RPCD-II), equipped with a digital hydrophone, main memory (2 TB storage), a central processing unit, and a wireless transmission module. We deployed the RPCD-II under a docked fishing vessel at the Ganjiang River in Yangzi Zhou Town Fisheries Village, Nanchang City (8–9 December 2021), where it recorded signals of Yangtze finless porpoise and produced a real-time report. To validate the results of RPCD-II, another underwater sound recorder, the SoundTrap 300HF (ST), was also set up (as a control device) under the docked fishing vessel. Both devices recorded consistent results of 9330 clicks, further demonstrating RPCD-II’s ability for the real-time detection of Yangtze finless porpoise in the field.

Truncated analog Brevinin2-CE-N26V5K: Revelation the Augmentation of Antimicrobial Activity - Yi Zhao; Xiao-yan Wang; Yan Sun; Zhi Li; Tao Liu; Qing-mei Liu; Jingyi Chen (World Journal of Microbiology and Biotechnology, 2022)

Altered Retinal Dopamine Levels in a Melatonin-proficient Mouse Model of Form-deprivation Myopia - Kang-Wei Qian; Yun-Yun Li; Xiao-Hua Wu; Xue Gong; Ai-Lin Liu; Wen-Hao Chen; Zhe Yang; Ling-Jie Cui; Yun-Feng Liu; Yuan-Yuan Ma; Chen-Xi Yu; Furong Huang; et al. (Neuroscience Bulletin, 2022)

Relationships Between Dietary Patterns and Low-Level Lead Exposure Among Children from Hunan Province of China - Zhi Huang; Xiao-chen Yin; Ming Chen; Mei-ling Li; Bo Chen; Yu-ming Hu (Exposure and Health, 2022)

Potential Specificity Between Mycorrhizal Fungi Isolated from Widespread Dendrobium spp. and Rare D. huoshanense Seeds - Yan-Jing Tang; Dong-Yu Zhou; Jun Dai; Yang Li; Yong-Mei Xing; Shun-Xing Guo; Juan Chen (Current Microbiology, 2022)

Using Genetic Algorithm and Particle Swarm Optimization BP Neural Network Algorithm to Improve Marine Oil Spill Prediction - Xueyan Cheng; Xupeng Hu; Zhenzhen Li; Chuanhui Geng; Jiaxing Liu; Mei Liu; Baikang Zhu; Qian Li; Qingguo Chen (Water, Air, & Soil Pollution, 2022)

Quick mapping and characterization of a co-located kernel length and thousand-kernel weight-related QTL in wheat - Xiangru Qu; Cong Li; Hang Liu; Jiajun Liu; Wei Luo; Qiang Xu; Huaping Tang; Yang Mu; Mei Deng; Zhien Pu; Jun Ma; Qiantao Jiang; et al. (Theoretical and Applied Genetics, 2022)

Full-length gonad transcriptome analysis of Amur sturgeon Dmrt family genes: identification, characterization, and expression patterns during gonadal differentiation - Xiujuan Zhang; Guanyu Li; Jiabin Zhou; Mei Lv; Linmiao Li; Jinping Chen (Fish Physiology and Biochemistry, 2022)

Characteristics and influencing factors of energy consumption in Chinese rural households - Xiaowei Ma; Dandan Liu; Danni Chen; Mei Wang; Chuandong Li (Environmental Science and Pollution Research, 2022)

Association of cognitive impairment and reduced cortical thickness in prefrontal cortex and anterior cingulate cortex with treatment-resistant depression - Mu-Hong Chen; Wan-Chen Chang; Pei-Chi Tu; Wei-Chen Lin; Cheng-Ta Li; Wen-Sheng Huang; Ya-Mei Bai; Shih-Jen Tsai; Tung-Ping Su (Brain Imaging and Behavior, 2022)

Evansella halocellulosilytica sp. nov., an alkali-halotolerant and cellulose-dissolving bacterium isolated from bauxite residue - Guo-Hong Liu; Manik Prabhu Narsing Rao; Qian-Qian Chen; Jian-Mei Che; Huai Shi; Bo Liu; Wen-Jun Li (Extremophiles, 2022)

MdMYB88/124 modulates apple tree microRNA biogenesis through post-transcription processing and/or transcription pathway - Chun-dong Niu; Huan-ran Shi; Zi-tong Zhang; Tian-le Fan; Huan Dang; Peng-xiang Chen; Yin-peng Xie; Cha-na Bao; Feng-wang Ma; Qing-mei Guan; Xue-wei Li (Acta Physiologiae Plantarum, 2022)

Citrinin Derivatives From Penicillium Citrinum Y34 That Inhibit α-Glucosidase and ATP-Citrate Lyase - Shanji Chen; Danmei Tian; Jihua Wei; Cong Li; Yihan Ma; Xiaoshuang Gou; Yiran Shen; Mei Chen; Sihao Zhang; Jia Li; Bin Wu; Jinshan Tang (Frontiers in Marine Science, 2022)
Two new citrinin dimers bearing a 6,6-spiroketal moiety (1 and 2) and four known analogues (3–6), together with 18 known citrinin monomers (7–24), were isolated from the culture of hydrothermal vent-associated fungus Penicillium citrinum Y34. Their structures were identified by extensive spectroscopic analyses, 13 C NMR calculation in combination with DP4+, linear correlation coefficient ( R 2 ), and mean absolute error (MAE) values analyses, and electronic circular dichroism (ECD) calculation. The α -glucosidase and ATP-citrate lyase (ACL) inhibitory activities of isolated compounds were evaluated. Compounds 1, 3, and 12 displayed moderate α -glucosidase inhibitory activities with IC 50 values of 239.8, 176.2, and 424.4 μM, respectively. Enzyme kinetics investigations of 1 and 3 suggested their non-competitive inhibition of α -glucosidase with K i values of 204.3 and 212.7 μM, respectively. Meanwhile, compound 4 showed significant ACL inhibitory potential with an IC 50 value of 17.4 μM. Furthermore, the interactions of 1, 3, and 12 with α -glucosidase and 4 with ACL were investigated by molecular docking assay. This study demonstrates that citrinins, especially for their dimers, could be potential lead compounds for the development of new agents for the treatment of metabolic diseases.

Armochaetoglasins J and K: new cytochalasans from Chaetomium globosum - Li Cheng; Xi Zheng; Qin Li; Meng-Sha Wei; Chun-Mei Chen; Hu-Cheng Zhu; Chang-Li Zeng; Xin-Cai Hao; Yong-Hui Zhang (Natural Product Research, 2022)

Prelimbic proBDNF Facilitates Retrieval-Dependent Fear Memory Destabilization by Regulation of Synaptic and Neural Functions in Juvenile Rats - Wei Sun; Xiao Chen; Yazi Mei; Yang Yang; Xiaoliang Li; Lei An (Molecular Neurobiology, 2022)

Grain size-dependent geochemical evidence reveals provenance and implications of aeolian sands, Dinggye region, southern Tibet - You-gui Chen; Mei-hui Pan; Ze-wen Hao; Yu-han Qi; Chen-lu Li (Journal of Mountain Science, 2022)

The effects of Ni availability on H 2 production and N 2 fixation in a model unicellular diazotroph: The expression of hydrogenase and nitrogenase - Hsin‐Ting Li; Sing‐How Tuo; Mei‐Chen Lu; Tung‐Yuan Ho (Limnology and Oceanography, 2022)
We investigated the effects of Ni concentration on hydrogen (H 2 ) net production and nitrogen (N 2 ) fixation rates in a model unicellular diazotrophic cyanobacterium, Cyanothece . We quantified NiFe uptake hydrogenase of the diazotroph to examine how Ni deficiency affects the expression of hydrogenase and nitrogenase and N 2 fixation rates. We found that Ni availability controls its H 2 net production and the expression of HupL, the major subunit of the uptake hydrogenase. Low Ni availability induced low HupL expression levels while yielding high H 2 net production, and vice versa. We also identified the threshold range of Ni concentrations that may differentiate low and high H 2 net production patterns in the diazotroph. However, the substantial variations in Ni availability and H 2 net production did not affect nitrogenase expression and N 2 fixation rates in Cyanothece . From two independent studies in the Atlantic tropical and subtropical oceans, we found that dissolved Ni concentrations and H 2 oversaturation percentage exhibited a statistically significant negative correlation, which is consistent with the findings of this culture study. Overall, these results indicate that Ni availability may affect H 2 net production and concentrations in the euphotic zone of the oceanic regions. H 2 concentrations may be used as a promising proxy to reflect N 2 fixation activities in tropical and subtropical oceans only under Ni‐deficient conditions.

An ortholog of the MADS-box gene SEPALLATA3 regulates stamen development in the woody plant Jatropha curcas - Mei-Li Zhao; Zhi-Fang Zhou; Mao-Sheng Chen; Chuan-Jia Xu; Zeng-Fu Xu (Planta, 2022)

Establishment and optimization of PEG-mediated protoplast transformation in the microalga Haematococcus pluvialis - Chunli Guo; Muhammad Anwar; Rui Mei; Xinyi Li; Di Zhao; Yanan Jiang; Jieyi Zhuang; Chen Liu; Chaogang Wang; Zhangli Hu (Journal of Applied Phycology, 2022)
Genetic manipulation of Haematococcus pluvialis is difficult because of the lack of a stable and convenient transformation system. The pH124-EGFP-Ble vector containing ble as a selective gene and EGFP as a reporter gene was constructed and employed for effective transformation. H. pluvialis protoplasts were obtained by treating with cellulase and macerozeme. Then polyethylene glycol-mediated transformation was established by incubating the protoplast with the vector. To improve the transformation efficiency of H. pluvialis protoplasts, the transformation system was optimized in consideration of different influencing factors, including zeomycin concentration, growth stage, amount of transformed vector, linearization of the vector, and duration of low-intensity illumination. The integration and expression of ble and EGFP was confirmed in the transformants. Moreover, the optimal combination for protoplast transformation of H. pluvialis was determined to be 5 µg of the linearized vector used to transform cells in the log growth phase, and then the transformed protoplasts allowed to recover under low-intensity illumination for 6 h. This study represents and describes the successful development of an H. pluvialis transformation protocol using protoplasts, which will enable convenient genetic manipulation of this important algal species.

Novel insights for PI3KC3 in mediating lipid accumulation in yellow catfish Pelteobagrus fulvidraco - Mei-Qin Zhuo; Jun Chen; Mei-Li Wu; Wen-Biao Wang (Fish Physiology and Biochemistry, 2022)

Numerical evaluation of face masks for prevention of COVID-19 airborne transmission - Jiaxing Liu; Ming Hao; Shulei Chen; Yang Yang; Jian Li; Qi Mei; Xin Bian; Kun Liu (Environmental Science and Pollution Research, 2022)
The COVID-19 pandemic has forced governments around the globe to apply various preventive measures for public health. One of the most effective measures is wearing face masks, which plays a vital role in blocking the transmission of droplets and aerosols. To understand the protective mechanism of face masks, especially in indoor environments, we apply a computational fluid dynamics technique to predict the lifetime of cough droplets. Therefore, we can assess the exposure risk in a ventilated room where an infected individual wears a face mask or not. We focus on the dynamic evaporation and diffusion of droplets in a human-cough process, which is a major cause for the spread of the virus. We find that wearing a face mask can effectively reduce the total mass and Sauter mean diameter of the residual droplets after a single cough. The mass concentration of virus-carrying droplets in the ventilated room decreases by 201, 43,786, and 307,060 times, corresponding to wearing cotton face masks, surgical face masks, and N95 face masks, respectively. However, the maximum travel distance of 80% droplets is insensitive to wearing a face mask or not. Therefore, the residual droplets are widely distributed due to the influence of indoor airflow. Furthermore, we study aerosol exposure risks in different areas of the room and find that high concentrations of aerosols occur in the streamline through an infected individual, especially next to the individual within 1.5 m. This strongly suggests a social distance despite the fact that the majority of droplets are filtered by face masks. This study explains the impact of face masks and airflow on indoor exposure risks and further inspires potential measures for public health, for example, no individuals should sit near the air supply opening.

Identification and feeding characteristics of the mixotrophic flagellate Poterioochromonas malhamensis, a microalgal predator isolated from planting water of Pontederia cordata - Hao Yan; Qin Li; Bo Chen; Mei Shi; Tingting Zhang (Environmental Science and Pollution Research, 2022)

Astragalus Polysaccharides Reduce High-glucose-induced Rat Aortic Endothelial Cell Senescence and Inflammasome Activation by Modulating the Mitochondrial Na+/Ca2+ Exchanger - Xin-Yu Miao; Xiao-Xiao Zhu; Zhao-Yan Gu; Bo Fu; Shao-Yuan Cui; Yuan Zu; Ling-Jun Rong; Fan Hu; Xiang-Mei Chen; Yan-Ping Gong; Chun-Lin Li (Cell Biochemistry and Biophysics, 2022)

Phenolic compounds from the sclerotia of Inonotus obliquus - Yan-Mei Wei; Li Yang; Wen-Li Mei; Hui-Qin Chen; Cai-Hong Cai; Wei Li; Wen-Hua Dong; Zhi-Bao Chen; Hao-Fu Dai (Natural Product Research, 2022)

PdeHCA2 affects biomass in Populus by regulating plant architecture, the transition from primary to secondary growth, and photosynthesis - Biligen-Gaowa Zhao; Guo Li; Yue-Feng Wang; Zhen Yan; Feng-Qin Dong; Ying-Chang Mei; Wei Zeng; Meng-Zhu Lu; Hong-Bin Li; Qing Chao; Bai-Chen Wang (Planta, 2022)

Increase in rosmarinic acid accumulation and transcriptional responses of synthetic genes in hairy root cultures of Prunella vulgaris induced by methyl jasmonate - Mei Ru; Yonghua Li; Min Guo; Liuyan Chen; Yong Tan; Liang Peng; Zongsuo Liang (Plant Cell, Tissue and Organ Culture (PCTOC), 2022)

Differences of carbon and nitrogen stoichiometry between different habitats in two natural Korean pine forests in Northeast China’s mountainous areas - Ya-fei Wang; Wen-biao Duan; Mei-xue Qu; Li-xin Chen; Hang-yu Lan; Xi-feng Yang; Si-jing Meng; Jia Chen (Journal of Mountain Science, 2022)

Neobacillus rhizophilus sp. nov. and Neobacillus citreus sp. nov., isolated from the citrus rhizosphere soil - Guo-Hong Liu; Manik Prabhu Narsing Rao; Qian-Qian Chen; Huai Shi; Jian-Mei Che; Bo Liu; Wen-Jun Li (Archives of Microbiology, 2022)

A new picrotoxane-type sesquiterpene from Dendrobium nobile Lindl - Pei Wang; Xin Chen; Cai-Hong Cai; Fan-Dong Kong; Sheng-Zhuo Huang; Jing-Zhe Yuan; Xing-Lian Xu; Wen-Li Mei; Hao-Fu Dai (Natural Product Research, 2022)

Enhanced genome editing to ameliorate a genetic metabolic liver disease through co-delivery of adeno-associated virus receptor - Shuming Yin; Lie Ma; Tingting Shao; Mei Zhang; Yuting Guan; Liren Wang; Yaqiang Hu; Xi Chen; Honghui Han; Nan Shen; Wenjuan Qiu; Hongquan Geng; et al. (Science China Life Sciences, 2022)

The complete chloroplast genome sequence of Clerodendranthus spicatus, a medicinal plant for preventing and treating kidney diseases from Lamiaceae family - Qing Du; Mei Jiang; Sihui Sun; Liqiang Wang; Shengyu Liu; Chuanbei Jiang; Haidong Gao; Haimei Chen; Yong Li; Bin Wang; Chang Liu (Molecular Biology Reports, 2022)

Genetic diversity and population structure of Curcuma alismatifolia Gagnep. accessions revealed by SSR markers - Hui-Wen Yu; Ling-Jun Ke; Yi-Lan Xiao; Si-Jia Chen; Yuan-Yuan Li; Qi-Lin Tian; Yun-He Li; Jin-Shui Lin; Luan-Mei Lu (Genetic Resources and Crop Evolution, 2022)

Cloning and expression of kiss genes and regulation of feeding in Siberian sturgeon (Acipenser baerii) - Shaoqi Xu; Mei Wang; Ya Li; Ni Tang; Xin Zhang; Hu Chen; Shupeng Zhang; Yanling Liu; Jun Wang; Defang Chen; Zhiqiong Li (Fish Physiology and Biochemistry, 2022)

Correction to: Lederbergia citri sp. nov., and Lederbergia citrisecundus sp. nov., isolated from citrus rhizosphere - Guo‑Hong Liu; Manik Prabhu Narsing Rao; Qian‑Qian Chen; Jian‑Mei Che; Huai Shi; Bo Liu; Wen‑Jun Li (Current Microbiology, 2022)

Inhibition of red chlorophyll catabolite reductase improved chlorophyll and carotenoid synthesis in tobacco - Chen Dong; Mei Zhang; Fang Wei; Yushuang Guo; Lili Qin; Pan Wei; Yubo Wang; Lifeng Jin; Weina Song; Tao Sun; Feng Li; Ran Wang (Plant Cell, Tissue and Organ Culture (PCTOC), 2022)

Activation of multiple proteolysis systems contributes to acute cadmium cytotoxicity - Yen-Hsiu Yeh; Chia-Chih Tsai; Tien-Wen Chen; Chieh-Hua Lee; Wei-Jer Chang; Mei-Yi Hsieh; Tsai-Kun Li (Molecular and Cellular Biochemistry, 2022)

Identification of epigenetic modifications mediating the antagonistic effect of selenium against cadmium-induced breast carcinogenesis - Zhuo-Zhi Liang; Yi-Xin Zhang; Rui-Mei Zhu; Yue-Lin Li; Hong-Mei Jiang; Ruo-Bi Li; Qian-Xin Chen; Qing Wang; Lu-Ying Tang; Ze-Fang Ren (Environmental Science and Pollution Research, 2022)

A comprehensive exploration on the health risk quantification assessment of soil potentially toxic elements from different sources around large-scale smelting area - Chang-Chen Huang; Li-Mei Cai; Yao-Hui Xu; Luo Jie; Lai-Guo Chen; Guo-Cheng Hu; Hui-Hao Jiang; Xu-Bang Xu; Jing-Xian Mei (Environmental Monitoring and Assessment, 2022)

Cancer metabolism and tumor microenvironment: fostering each other? - Yiyuan Yuan; Huimin Li; Wang Pu; Leilei Chen; Dong Guo; Hongfei Jiang; Bo He; Siyuan Qin; Kui Wang; Na Li; Jingwei Feng; Jing Wen; et al. (Science China Life Sciences, 2022)

Susceptibility of patients with chronic obstructive pulmonary disease to heart rate difference associated with the short-term exposure to metals in ambient fine particles: A panel study in Beijing, China - Ke Gao; Xi Chen; Xiaoying Li; Hanxiyue Zhang; Mengxiao Luan; Yuan Yao; Yifan Xu; Teng Wang; Yiqun Han; Tao Xue; Junxia Wang; Mei Zheng; et al. (Science China Life Sciences, 2022)

Oxygen Metabolism-induced Stress Response Underlies Heart–brain Interaction Governing Human Consciousness-breaking and Attention - Xiao-Juan Xue; Rui Su; Ze-Feng Li; Xiao-Ou Bu; Peng Dang; Si-Fang Yu; Zhi-Xin Wang; Dong-Mei Chen; Tong-Ao Zeng; Ming Liu; Hai-Lin Ma; De-Long Zhang (Neuroscience Bulletin, 2022)

Lederbergia citri sp. nov., and Lederbergia citrisecundus sp. nov., isolated from citrus rhizosphere - Guo-Hong Liu; Manik Prabhu Narsing Rao; Qian-Qian Chen; Jian-Mei Che; Huai Shi; Bo Liu; Wen-Jun Li (Current Microbiology, 2022)

Development and validation of a 30-day death nomogram in patients with spontaneous cerebral hemorrhage: a retrospective cohort study - Qian Han; Mei Li; Dongpo Su; Aijun Fu; Lin Li; Tong Chen (Acta Neurologica Belgica, 2022)

HMGB1-RAGE Pathway Contributes to the Abnormal Migration of Endogenous Subventricular Zone Neural Progenitors in an Experimental Model of Focal Microgyria - Yi-Wen Mei; Tian-Lan Huang; Xin Chen; Si-Xun Yu; Jie Li; Zhi Zhang; Yang He; Da-qing Guo; Hai-Feng Shu (Journal of Molecular Neuroscience, 2022)

Nakamurella leprariae sp. nov., isolated from a lichen sample - De-Feng An; Shao-Juan Yang; Long-Qian Jiang; Xin-Yu Wang; Xiao-Yu Huang; Lei Lang; Xue-Mei Chen; Ming-Qun Fan; Gui-Ding Li; Ming-Guo Jiang; Li-Song Wang; Cheng-Lin Jiang; et al. (Archives of Microbiology, 2022)

Biogeography of culturable marine bacteria from both poles reveals that ‘everything is not everywhere’ at the genomic level - Qi‐Long Qin; Zhi‐Bin Wang; Qian‐Qian Cha; Sha‐Sha Liu; Xue‐Bing Ren; Hui‐Hui Fu; Mei‐Ling Sun; Dian‐Li Zhao; Andrew McMinn; Yin Chen; Xiu‐Lan Chen; Yu‐Zhong Zhang; et al. (Environmental Microbiology, 2022)
Summary Based on 16S rRNA gene analyses, the same bacterial operational taxonomic units (OTUs) are common to both the Arctic and Antarctic oceans, supporting the concept ‘everything is everywhere’. However, whether the same OTUs from both poles have identical genomes, i.e. whether ‘everything is still everywhere’ at the genomic level has not yet been examined systematically. Here, we isolated, sequenced and compared the genomes of 45 culturable marine bacteria belonging to three genera of Salinibacterium , Psychrobacter and Pseudoalteromonas from both polar oceans. The bacterial strains with identical 16S rRNA genes were common to both poles in every genus, and four identical genomes were detected in the genus Salinibacterium from the Arctic region. However, no identical genomes were observed from opposite poles in this study. Our data, therefore, suggest that ‘everything is not everywhere’ at the genomic level. The divergence time between bacteria is hypothesized to exert a strong impact on the bacterial biogeography at the genomic level. The geographical isolation between poles was observed for recently diverged, highly similar genomes, but not for moderately similar genomes. This study thus improves our understanding of the factors affecting the genomic‐level biogeography of marine microorganisms isolated from distant locations.

Analysis of the starch properties in tetraploid wheat–Aegilops sharonensis amphidiploid - Qing Li; Xuteng Zhang; Na Lin; Guzmán Carlos; Jingyu Lan; Huaping Tang; Pengfei Qi; Jian Ma; Jirui Wang; Guoyue Chen; Wei Li; Zhien Pu; et al. (Cereal Research Communications, 2021)

Three new diterpenoids from Euphorbia peplus - Yan-Ni Chen; Qing-Yun Lu; Dong-Mei Li; Ying-Yao Li; Xue-Xue Pu; Bo-Ting Li; Xiao-Han Tang; Hong-Yu Tang; Shuai Liu; Lei Yang; Yu Zhang; Ying-Tong Di; et al. (Natural Product Research, 2021)

Three new dimeric 2-(2-phenylethyl)chromones from artificial agarwood of Aquilaria sinensis - Pan Xiang; Wen-Hua Dong; Cai-Hong Cai; Wei Li; Li-Man Zhou; Hao-Fu Dai; Hui-Qin Chen; Wen-Li Mei (Natural Product Research, 2021)

RETRACTED ARTICLE: Characterization of Preclinical Pharmacokinetic Properties and Prediction of Human PK Using a Physiologically Based Pharmacokinetic Model for a Novel Anti-Arrhythmic Agent Sulcardine Sulfate - Chang Ren; Yao Wang; Mei Zhang; Dexuan Kong; Chen Ning; Yujie Cheng; Yueying Bian; Mengqi Sun; Shengdi Su; Yucong Wang; Yongjie Zhang; Yang Lu; et al. (Pharmaceutical Research, 2021)

Genomic characterization of a rare Carica papaya X chromosome mutant reveals a candidate monodehydroascorbate reductase 4 gene involved in all-hermaphrodite phenomenon - Jen-Ren Chen; Hiroki Ueno; Hideo Matsumura; Naoya Urasaki; Chen-Yu Lee; Fure-Chyi Chen; Shih-Wen Chin; Chun-Chi Liu; Chan-Tai Chiu; Kazuhiko Tarora; Jing-Yi Li; Chieh Ying Lee; et al. (Molecular Genetics and Genomics, 2021)

A comprehensive exploration on pollution characteristics and health risks of potentially toxic elements in indoor dust from a large Cu smelting area, Central China - Han-Zhi Wang; Li-Mei Cai; Shuo Wang; Guo-Cheng Hu; Lai-Guo Chen (Environmental Science and Pollution Research, 2021)

Wuchuan bronzes and cinnabar mining immigrants during the Qin and Han Dynasties—new perspectives from typological and lead isotope analysis - Mei Huang; Xiaotong Wu; Xinzhou Chen; Li Tao; Xiaohua Wu; Min Shi; Fei Li; Melissa M. Ritchey; Fang Huang; Zhengyao Jin (Archaeological and Anthropological Sciences, 2021)

A new ergostane derivative from the leaves of Heynea trijuga Roxburgh - Shou-Bai Liu; Zheng Cui; Hui-Qin Chen; Hao Wang; Wen-Hua Dong; Cai-Hong Cai; Wen-Li Mei; Hao-Fu Dai (Natural Product Research, 2021)

Chronic Exposure to Hypoxia Inhibits Myelinogenesis and Causes Motor Coordination Deficits in Adult Mice - Lin Chen; Shu-Yu Ren; Rui-Xue Li; Kun Liu; Jing-Fei Chen; Yu-Jian Yang; Yong-Bin Deng; Han-Zhi Wang; Lan Xiao; Feng Mei; Fei Wang (Neuroscience Bulletin, 2021)
Exposure to chronic hypoxia is considered to be a risk factor for deficits in brain function in adults, but the underlying mechanisms remain largely unknown. Since active myelinogenesis persists in the adult central nervous system, here we aimed to investigate the impact of chronic hypoxia on myelination and the related functional consequences in adult mice. Using a transgenic approach to label newly-generated myelin sheaths ( NG2-CreER TM ; Tau-mGFP ), we found that myelinogenesis was highly active in most brain regions, such as the motor cortex and corpus callosum. After exposure to hypoxia (10% oxygen) 12 h per day for 4 weeks, myelinogenesis was largely inhibited in the 4-month old brain and the mice displayed motor coordination deficits revealed by the beam-walking test. To determine the relationship between the inhibited myelination and functional impairment, we induced oligodendroglia-specific deletion of the transcription factor Olig2 by tamoxifen ( NG2-CreER TM ; Tau-mGFP; Olig2 fl/fl ) in adult mice to mimic the decreased myelinogenesis caused by hypoxia. The deletion of Olig2 inhibited myelinogenesis and consequently impaired motor coordination, suggesting that myelinogenesis is required for motor function in adult mice. To understand whether enhancing myelination could protect brain functions against hypoxia, we treated hypoxic mice with the myelination-enhancing drug-clemastine, which resulted in enhanced myelogenesis and improved motor coordination. Taken together, our data indicate that chronic hypoxia inhibits myelinogenesis and causes functional deficits in the brain and that enhancing myelinogenesis protects brain functions against hypoxia-related deficits.

Cysestermerol A, a rare stilbene sestermer with significant hypoglycemic activities from Cynodon dactylon - Feng Wang; Li Zhang; Bi-Jun Li; Qiu-Ming Liang; A-Li Chen; Zhen-Feng Fang; Shu-Mei Wang (Natural Product Research, 2021)

The effect of typical geological heterogeneities on the performance of managed aquifer recharge: physical experiments and numerical simulations - Peipeng Wu; Longcang Shu; Jean-Christophe Comte; Qiting Zuo; Mei Wang; Fulin Li; Huawei Chen (Hydrogeology Journal, 2021)

Apigenin Improves Hypertension and Cardiac Hypertrophy Through Modulating NADPH Oxidase-Dependent ROS Generation and Cytokines in Hypothalamic Paraventricular Nucleus - Hong-Li Gao; Xiao-Jing Yu; Han-Bo Hu; Qian-Wen Yang; Kai-Li Liu; Yan-Mei Chen; Yan Zhang; Dong-Dong Zhang; Hua Tian; Guo-Qing Zhu; Jie Qi; Yu-Ming Kang (Cardiovascular Toxicology, 2021)

Effects of temperature on the locomotor performance and contraction properties of skeletal muscle from two Phrynocephalus lizards at high and low altitude - Zhiyi Niu; Mei Li; Peng Pu; Huihui Wang; Tao Zhang; Xiaolong Tang; Qiang Chen (Journal of Comparative Physiology B, 2021)

Dicer Deletion in Astrocytes Inhibits Oligodendroglial Differentiation and Myelination - Kun Liu; Bin Yu; Jing-Fei Chen; Rui-Xue Li; Lin Chen; Shu-Yu Ren; Fei Wang; Feng Mei; Lan Xiao (Neuroscience Bulletin, 2021)
Increasing evidence has shown that astrocytes are implicated in regulating oligodendrocyte myelination, but the underlying mechanisms remain largely unknown. To understand whether microRNAs in astrocytes function in regulating oligodendroglial differentiation and myelination in the developing and adult CNS, we generated inducible astrocyte-specific Dicer conditional knockout mice (hGFAP-CreERT; Dicer fl/fl). By using a reporter mouse line (mT/mG), we confirmed that hGFAP-CreERT drives an efficient and astrocyte-specific recombination in the developing CNS, upon tamoxifen treatment from postnatal day 3 (P3) to P7. The Dicer deletion in astrocytes resulted in inhibited oligodendroglial differentiation and myelination in the developing CNS of Dicer cKO mice at P10 and P14, and did not alter the densities of neurons or axons, indicating that Dicer in astrocytes is required for oligodendrocyte myelination. Consequently, the Dicer deletion in astrocytes at P3 resulted in impaired spatial memory and motor coordination at the age of 9 weeks. To understand whether Dicer in astrocytes is also required for remyelination, we induced Dicer deletion in 3-month-old mice and then injected lysolecithin into the corpus callosum to induce demyelination. The Dicer deletion in astrocytes blocked remyelination in the corpus callosum 14 days after induced demyelination. Together, our results indicate that Dicer in astrocytes is required for oligodendroglia myelination in both the developing and adult CNS.

Application of Plant Print Identification Technology in Salt-resistant Soybean Breeding - Yan Li; Xia Li; Zi-qi Chen; Ying Ma; Guang-yu Yang; Ying Zhang; Ming-chun Sun; Li-hong Zhang; Jin-meng Chu; Jing-mei Lu; Jun Zhu; Ji-hong You (Journal of Plant Growth Regulation, 2021)

Dissecting the meteorological and genetic factors affecting rice grain quality in Northeast China - Mojun Chen; Zhao Li; Jie Huang; Yongfeng Yan; Tao Wu; Mingdi Bian; Jinsong Zhou; Yongjun Wang; Yanjie Lyv; Guanghui Hu; Yong-Mei Jin; Kai Huang; et al. (Genes & Genomics, 2021)
Background The Northeast Plain of China, which is an important region for the production of high grain quality rice in China. However, the grain quality of the rice produced varies across this region, even for the same cultivar. Objective In order to explore the meteorological factors that have the greatest influence on quality and the transcriptional level differences between different cultivars and different locations at grain filling stage. Methods We grew eight rice cultivars in three locations in Northeast China during two growing seasons (2017 and 2018). We recorded meteorological conditions, including air temperature, air temperature range, and photosynthetically active radiation (PAR) during the grain-filling stage of each cultivar, and analyzed the grain quality of those eight cultivars. Results Across all eight cultivars, meteorological factors had a stronger effect on eating quality than genotype, while genotype had a stronger effect on milling quality. Of the three environmental factors assessed, PAR was significantly correlated with the most grain quality traits. Using RNA-sequencing analysis, we identified 573 environment-specific DEGs (Differentially Expressed Genes), and 119 genotype-specific DEGs; 11 DEGs were responsive to genotype × environment interactions. These DEGs were involved in many key metabolic processes. Conclusion Our results indicated that interactions among environmental factors, especially PAR, affected rice quality in Northeast China. Further analyses of the DEGs identified herein may provide useful information for future breeding programs aiming to develop high grain quality rice varieties suitable for cultivation across Northeast China.

Three new 5,6,7,8-tetrahydro-2-(2-phenylethyl)chromones and one new dimeric 2-(2-phenylethyl)chromone from agarwood of Aquilaria crassna Pierre ex Lecomte in Laos - Yang-Mei Zhao; Li Yang; Fan-Dong Kong; Wen-Hua Dong; Wei Li; Hui-Qin Chen; Hao Wang; Cai-Hong Cai; Cui-Juan Gai; Wen-Li Mei; Hao-Fu Dai (Natural Product Research, 2021)

Energy choice in rural household cooking and heating: influencing factors and transformation patterns - Xiaowei Ma; Mei Wang; Danni Chen; Chuandong Li (Environmental Science and Pollution Research, 2021)

Marinifaba aquimaris gen. nov., sp. nov., a novel chitin‐degrading gammaproteobacterium in the family Alteromonadaceae isolated from seawater of the Mariana Trench - Xin Sui; Xiao-yan He; Ning-hua Liu; Yan-ru Dang; Qian-qian Cha; Mei-ling Sun; Chun-yang Li; Hui-hui Fu; Xiao-yan Song; Qi-long Qin; Xiu-lan Chen; Yu-zhong Zhang; et al. (Antonie van Leeuwenhoek, 2021)

Somatic embryogenesis of masson pine (Pinus massoniana): initiation, maturation and genetic stability analysis at SSR loci - Xin-Rui Xia; Fan Yang; Xin Ke; You-Mei Chen; Jian-Ren Ye; Li-Hua Zhu (Plant Cell, Tissue and Organ Culture (PCTOC), 2021)

Genetic Architecture of Childhood Kidney and Urological Diseases in China - Ye Fang; Hua Shi; Tianchao Xiang; Jiaojiao Liu; Jialu Liu; Xiaoshan Tang; Xiaoyan Fang; Jing Chen; Yihui Zhai; Qian Shen; Guomin Li; Li Sun; et al. (Phenomics, 2021)
Kidney disease is manifested in a wide variety of phenotypes, many of which have an important hereditary component. To delineate the genotypic and phenotypic spectrum of pediatric nephropathy, a multicenter registration system is being implemented based on the Chinese Children Genetic Kidney Disease Database (CCGKDD). In this study, all the patients with kidney and urological diseases were recruited from 2014 to 2020. Genetic analysis was conducted using exome sequencing for families with multiple affected individuals with nephropathy or clinical suspicion of a genetic kidney disease owing to early-onset or extrarenal features. The genetic diagnosis was confirmed in 883 of 2256 (39.1%) patients from 23 provinces in China. Phenotypic profiles showed that the primary diagnosis included steroid-resistant nephrotic syndrome (SRNS, 23.5%), glomerulonephritis (GN, 32.2%), congenital anomalies of the kidney and urinary tract (CAKUT, 21.2%), cystic renal disease (3.9%), renal calcinosis/stone (3.6%), tubulopathy (9.7%), and chronic kidney disease of unknown etiology (CKDu, 5.8%). The pathogenic variants of 105 monogenetic disorders were identified. Ten distinct genomic disorders were identified as pathogenic copy number variants (CNVs) in 11 patients. The diagnostic yield differed by subgroups, and was highest in those with cystic renal disease (66.3%), followed by tubulopathy (58.4%), GN (57.7%), CKDu (43.5%), SRNS (29.2%), renal calcinosis /stone (29.3%) and CAKUT (8.6%). Reverse phenotyping permitted correct identification in 40 cases with clinical reassessment and unexpected genetic conditions. We present the results of the largest cohort of children with kidney disease in China where diagnostic exome sequencing was performed. Our data demonstrate the utility of family-based exome sequencing, and indicate that the combined analysis of genotype and phenotype based on the national patient registry is pivotal to the genetic diagnosis of kidney disease.

Genetic parameters for growth and Quambalaria shoot blight resistance in Corymbia citriodora subsp. variegata - Shengkan Chen; Jianbo Chen; Guanming Yi; Mei Qin; Shiqi Ren; Ziyu Deng; Qinglan Tang; Dongqiang Guo; Yuanli Zhu; Zhangqi Yang; Chonglu Zhong; Siming Gan; et al. (Euphytica, 2021)

Enhanced treatment of shale gas fracturing waste fluid through plant-microbial synergism - Bo Shao; Xu Tan; Ju-Long Li; Mei He; Lei Tian; Wen-Jie Chen; Yan Lin (Environmental Science and Pollution Research, 2021)

Proton Pump Inhibitor Exposure and Acute Myocardial Infarction Risk: A Nested Cohort Study - Hsiang-Jung Tseng; Chih-Ming Cheng; Shih-Jen Tsai; Wei-Chen Lin; Ya-Mei Bai; Chia-Fen Tsai; Tung-Ping Su; Cheng-Ta Li; Tzeng-Ji Chen; Mu-Hong Chen (Cardiovascular Toxicology, 2021)

Nutrigenomics reveals potential genetic underpinning of diverse taste preference of Chinese men - Zhouhai Zhu; Junpu Mei; Silong Sun; Sheming Lu; Meng Li; Ying Guan; Ying Chen; Yuqiong Xu; Tao Zhang; Fengxue Shi; Xuemei Li; Mingming Miao; et al. (Genes & Genomics, 2021)

Tritonibacter aquimaris sp. nov. and Tritonibacter litoralis sp. nov., two novel members of the Roseobacter group isolated from coastal seawater - Na Li; Xiao-yan He; Ning-hua Liu; Tie-ji Gu; Jian Li; Yu-hui Geng; Shan Zhang; Peng Wang; Hui-hui Fu; Mei Shi; Xiu-lan Chen; Yu-zhong Zhang; et al. (Antonie van Leeuwenhoek, 2021)

Spatial prediction of soil calcium carbonate content based on Bayesian maximum entropy using environmental variables - Mei Shan; Shuang Liang; Hongchen Fu; Xiaoli Li; Yu Teng; Jingwen Zhao; Yaxin Liu; Chen Cui; Li Chen; Hai Yu; Shunbang Yu; Yanling Sun; et al. (Nutrient Cycling in Agroecosystems, 2021)

Spatial variation and fractionation of fluoride in tobacco-planted soils and leaf fluoride concentration in tobacco in Bijie City, Southwest China - Mei Wang; Long Zhang; Yanxiang Liu; Dan Chen; Lei Liu; Caibing Li; Kyong Ju Kang; Lingyu Wang; Zhenli He; Xiaoe Yang (Environmental Science and Pollution Research, 2021)

Identification and characterization of CONSTANS-like genes from Curcuma alismatifolia - Yuan-Yuan Li; Xiao-Huang Chen; Hui-Wen Yu; Qi-Lin Tian; Luan-Mei Lu (Horticulture, Environment, and Biotechnology, 2021)

The prevalence and risks of major comorbidities among inpatients with pulmonary tuberculosis in China from a gender and age perspective: a large-scale multicenter observational study - Wanli Kang; Jian Du; Song Yang; Jiajia Yu; Hongyan Chen; Jianxiong Liu; Jinshan Ma; Mingwu Li; Jingmin Qin; Wei Shu; Peilan Zong; Yi Zhang; et al. (European Journal of Clinical Microbiology & Infectious Diseases, 2021)

Microbiological profiles and antimicrobial resistance patterns of pediatric bloodstream pathogens in China, 2016–2018 - Yue Qiu; Junwen Yang; Yiping Chen; Jinhong Yang; Qingxiong Zhu; Chunhui Zhu; Shuangjie Li; Jing Liu; Chaomin Wan; Yu Zhu; Minxia Chen; Yi Xu; et al. (European Journal of Clinical Microbiology & Infectious Diseases, 2021)

Impact of solar ultraviolet radiation on daily outpatient visits of atopic dermatitis in Shanghai, China - Hui-jing Gu; Li Peng; Wen-cai Jiang; Yi-mei Tan; Guo-jiang Zhou; Hai-dong Kan; Ren-jie Chen; Ying Zou (Environmental Science and Pollution Research, 2021)

Biotransformation of Phlorizin by Eurotium cristatum to Increase the Antioxidant and Antibacterial Activity of Docynia indica Leaves - Jie Xie; Jiang Chen; Xue-ran Mei; Ming-jun Zhu; Xue-li Li; Juan Du; Xiao-yu Zhang (Current Microbiology, 2021)

Haplotype networks of Phycocalidia tanegashimensis (Bangiales, Rhodophyta) indicate a probable invasion from the South China Sea to Brazil - Wan Zhao; Lei Dong; Dang Diem Hong; Juliet Brodie; Wei-Zhou Chen; Dam Duc Tien; Wei Zhou; Qin-Qin Lu; Mei-Ru Zhang; Li-En Yang (Marine Biodiversity, 2021)

Interest-activity symptom severity predicts response to ketamine infusion in treatment-resistant depression - Mu-Hong Chen; Wei-Chen Lin; Hui-Ju Wu; Ya-Mei Bai; Cheng-Ta Li; Shih-Jen Tsai; Chen-Jee Hong; Pei-Chi Tu; Tung-Ping Su (Psychopharmacology, 2021)

Thiazole-based and thiazolidine-based protein tyrosine phosphatase 1B inhibitors as potential anti-diabetes agents - Kexin Chen; Xu Yao; Ting Tang; Li-Mei Chen; Can Xiao; Jing-Yi Wang; Hong-Fei Chen; Zhong-Xing Jiang; Yi Liu; Xing Zheng (Medicinal Chemistry Research, 2021)

Genetic diversity analysis of Topmouth Culter (Culter alburnus) based on microsatellites and D-loop sequences - Ning Sun; Dong-Mei Zhu; Qing Li; Gui-Ying Wang; Jian Chen; Feifei Zheng; Pei Li; Yan-Hong Sun (Environmental Biology of Fishes, 2021)

A global analysis on the systemic effects of antibiotics in cultured fish and their potential human health risk: a review - Samwel Mchele Limbu; Li‐Qiao Chen; Mei‐Ling Zhang; Zhen‐Yu Du (Reviews in Aquaculture, 2021)
The rearing of fish in intensive systems reduces their immunity leading to eruption of diseases, consequently prompting the use of antibiotics. Antibiotics are currently used in cultured fish globally to treat/prevent diseases. On the one hand, antibiotics used in aquaculture help to improve fish health by killing or inhibiting pathogenic bacteria proliferation. However, on the other hand, they cause multiple side effects. To date, information on systemic effects of antibiotics in cultured fish is scattered and their potential human health risk remains elusive. This review critically analyses and discusses the available information in the literature on the positive and negative effects of antibiotics in cultured fish and their potential human health risk via fish consumption. The review found 44 different antibiotics dominated by oxytetracycline were studied in various fish species worldwide. Antibiotics used in global aquaculture either decrease or increase fish growth and survival rates. They induce oxidative stress, which affect antioxidant and detoxification responses and cause host–microbiota dysbiosis. These changes compromise the fish immunity system, which ultimately lead to cellular damage. The toxicities generated inhibit the fish aerobic glycolysis, suppress lipogenesis and fatty acid β‐oxidation while increase energy demand by initiating gluconeogenesis and anaerobic glycolysis. Consumption of fish treated with antibiotics causes human health risk. Future studies are required on agents to restore dysfunctions induced by antibiotics in cultured fish, while attempts to limit their utilisation in aquaculture production are underway. [Correction added on 21 November 2020, after first online publication: The abstract has been amended to clarify the scope of the review.]

Paeonol ameliorates CFA-induced inflammatory pain by inhibiting HMGB1/TLR4/NF-κB p65 pathway - Chen Qiu; Liu-Di Yang; Wen Yu; Dan-Dan Tian; Mei-Rong Gao; Wen-Ju Wang; Xu-Bo Li; Yu-Mei Wu; Min Wang (Metabolic Brain Disease, 2021)

Conversion of polysaccharides in Ulva prolifera to valuable chemicals in the presence of formic acid - Yingdong Zhou; Mei Li; Yaguang Chen; Changwei Hu (Journal of Applied Phycology, 2021)

The reduction of lipid-sourced energy production caused by ATGL inhibition cannot be compensated by activation of HSL, autophagy, and utilization of other nutrients in fish - Si-Lan Han; Yan Liu; Samwel M. Limbu; Li-Qiao Chen; Mei-Ling Zhang; Zhen-Yu Du (Fish Physiology and Biochemistry, 2021)

Evaluation of the combined effect of sodium persulfate and thermal hydrolysis on sludge dewatering performance - Kai Chen; Jingxin Liu; Simian Huang; Meng Mei; Si Chen; Teng Wang; Jinping Li (Environmental Science and Pollution Research, 2021)

Maximum July–September temperatures derived from tree‐ring densities on the western Loess Plateau, China - Huiming Song; Ruochen Mei; Yu Liu; Daniel Nievergelt; Anne Verstege; Paolo Cherubini; Ruoshi Liu; Changfeng Sun; Qiang Li; Ling Chen; Xueli Zeng; Junqin Guo (International Journal of Climatology, 2021)
Tree‐ring densitometric studies conducted in semi‐arid regions are exceedingly rare. In this study, we evaluate a new maximum latewood density chronology from a collection of Picea purpurea trees growing in semi‐arid northwestern China for climatic reconstruction purposes. We find statistically significant correlations between annual maximum density variations and July–September maximum temperatures over the 1957–2014 calibration period. Using a linear model to transfer the density variations to temperature estimates, we then reconstruct maximum summer temperatures from 1840 to 2014. Statistical analyses and verification tests demonstrate that the resulting transfer function is both reliable and stable. The reconstructed temperature series shows strong inter‐annual and decadal variability. Several extremely cool and warm years are apparent on an inter‐annual scale, while three extended cool periods and a warm period are observed on a decadal scale. In addition, the reconstructed temperature series exhibits a pattern synchronous with that of the Indian monsoon index, as well as a moderate relationship to volcanic eruptions. This densitometric study reveals typical climatic variation characteristics and provides useful data for deepening our understanding of climate history in the semi‐arid regions of China.

Sesquiterpenoids and meroterpenoids from a mangrove derived fungus Diaporthe sp. SCSIO 41011 - Xiao-Wei Luo; Chun-Mei Chen; Kun-Long Li; Xiu-Ping Lin; Cheng-Hai Gao; Xue-Feng Zhou; Yong-Hong Liu (Natural Product Research, 2021)

Correction to: Inhibiting reactive oxygen species-dependent autophagy enhanced baicalein-induced apoptosis in oral squamous cell carcinoma - Bo Li; Mei Lu; Xin-Xiang Jiang; Meng‑Xiong Pan; Jun-Wu Mao; Mei Chen (Journal of Natural Medicines, 2021)

Effectiveness of predicting spatial contaminant distributions at industrial sites using partitioned interpolation method - Pengwei Qiao; Sucai Yang; Wenxia Wei; Peizhong Li; Yanjun Cheng; Shuang Liang; Mei Lei; Tongbin Chen (Environmental Geochemistry and Health, 2021)

A review on Cadmium Exposure in the Population and Intervention Strategies Against Cadmium Toxicity - Mei Wang; Zhaofang Chen; Wei Song; Dezi Hong; Lei Huang; Yunhui Li (Bulletin of Environmental Contamination and Toxicology, 2021)

A novel, validated, and plant height-independent QTL for spike extension length is associated with yield-related traits in wheat - Cong Li; Huaping Tang; Wei Luo; Xuemei Zhang; Yang Mu; Mei Deng; Yaxi Liu; Qiantao Jiang; Guoyue Chen; Jirui Wang; Pengfei Qi; Zhien Pu; et al. (Theoretical and Applied Genetics, 2020)

Identification, tissue distribution, periprandial expression, and anorexigenic effect of spexin in Siberian sturgeon, Acipenser baeri - Zhengzhi Tian; Shaoqi Xu; Mei Wang; Ya Li; Hu Chen; Ni Tang; Bin Wang; Xin Zhang; Zhiqiong Li (Fish Physiology and Biochemistry, 2020)

Larger regional volume of the thalamus in diarrhea-predominant irritable bowel syndrome: a cross-sectional study - Cui Ping Mao; Fen Rong Chen; Hong Hong Sun; Mei Juan Shi; Hua Juan Yang; Xiao Hui Li; Dun Ding (Brain Imaging and Behavior, 2020)

Comparative transcriptome analysis of gynoecious and monoecious inflorescences reveals regulators involved in male flower development in the woody perennial plant Jatropha curcas - Mei-Li Zhao; Mao-Sheng Chen; Jun Ni; Chuan-Jia Xu; Qing Yang; Zeng-Fu Xu (Plant Reproduction, 2020)

Spororrminone A and 2- epi -spororrminone A, two new chromones from an endolichenic fungus Sporormiella irregularis - Mei-Juan Huang; Yan-Jun Li; Jia Tang; Guo-Dong Chen; Dan Hu; Wei Xu; Liang-Dong Guo; Xin-Sheng Yao; Hao Gao (Natural Product Research, 2020)

Whether the carbon emission from green roofs can be effectively mitigated by recycling waste building material as green roof substrate during five-year operation? - Liangqian Fan; Jingting Wang; Xiaoling Liu; Hongbing Luo; Ke Zhang; Xiaoying Fu; Mei Li; Xiaoting Li; Bing Jiang; Jia Chen; Shuzhi Fu; You Mo; et al. (Environmental Science and Pollution Research, 2020)

Characteristics of methane emissions in the Living Water Garden in Chengdu City from 2012 to 2017 - Ru Xue; Xiaoling Liu; Xiaoying Fu; Hongbing Luo; Ke Zhang; Bruce C. Anderson; Mei Li; Bo Huang; Lijuan Yu; Xiaoting Li; Shuzhi Fu; Aiping Pu; et al. (Environmental Science and Pollution Research, 2020)

LMDS-1, a potential TrkB receptor agonist provides a safe and neurotrophic effect for early-phase Alzheimer’s disease - Chia-Hao Fan; Chia-Wei Lin; Hei-Jen Huang; Guey-Jen Lee-Chen; Ying-Chieh Sun; Wenwei Lin; Chiung-Mei Chen; Kuo-Hsuan Chang; Ming-Tsan Su; Hsiu Mei Hsieh-Li (Psychopharmacology, 2020)

Upregulation of long non-coding RNA MEG3 in type 2 diabetes mellitus complicated with vascular disease: a case–control study - Wei-wei Chang; Liu Zhang; Xin-ming Yao; Yan Chen; Li-jun Zhu; Zheng-mei Fang; Ying Zhao; Ying-shui Yao; Yue-long Jin (Molecular and Cellular Biochemistry, 2020)

A novel, major, and validated QTL for the effective tiller number located on chromosome arm 1BL in bread wheat - Jiajun Liu; Huaping Tang; Xiangru Qu; Hang Liu; Cong Li; Yang Tu; Shuiqing Li; Ahsan Habib; Yang Mu; Shoufeng Dai; Mei Deng; Qiantao Jiang; et al. (Plant Molecular Biology, 2020)

Identification of lncRNAs involved in wheat tillering development in two pairs of near-isogenic lines - Wanlin Zhou; Haoran Shi; Zhiqiang Wang; Yueting Zhao; Xiangjian Gou; Caixia Li; Guangdeng Chen; Shihang Liu; Mei Deng; Jian Ma; Youliang Zheng; Yuming Wei; et al. (Functional & Integrative Genomics, 2020)

Identification and validation of stable quantitative trait loci for grain filling rate in common wheat (Triticum aestivum L.) - Yu Lin; Xiaojun Jiang; Yang Tao; Xilan Yang; Zhiqiang Wang; Fangkun Wu; Shihang Liu; Caixia Li; Mei Deng; Jian Ma; Guangdeng Chen; Yuming Wei; et al. (Theoretical and Applied Genetics, 2020)

Neuroimaging Spectrum at Pre-, Early, and Late Symptomatic Stages of SCA17 Mice - Chiao-Chi Chen; Nai-Wei Yao; Chia-Wei Lin; Wei-Shuo Su; Chin-Tien Wu; Chen Chang; Hsiu Mei Hsieh-Li (The Cerebellum, 2020)

Effects of cultivars, water regimes, and growth stages on cadmium accumulation in rice with different radial oxygen loss - Xiuqin Mei; Qusheng Li; Hailong Wang; Hao Fang; Huijun Chen; Xin Chen; Yaoshuai Yang; Muhammad Rizwan; Zhihong Ye (Plant and Soil, 2020)

Impaired peroxisomal fat oxidation induces hepatic lipid accumulation and oxidative damage in Nile tilapia - Yan Liu; Si-Lan Han; Yuan Luo; Ling-Yu Li; Li-Qiao Chen; Mei-Ling Zhang; Zhen-Yu Du (Fish Physiology and Biochemistry, 2020)

Characterization, tissue distribution of resistin gene and the effect of fasting and refeeding on resistin mRNA expression in Siberian sturgeon ( Acipenser baerii ) - Ni Tang; Yanlin Liu; Zhengzhi Tian; Shaoqi Xu; Mei Wang; Hu Chen; Bin Wang; Ya Li; Yan Wang; Song Yang; Liulan Zhao; Defang Chen; et al. (Journal of Fish Biology, 2020)
Resistin as an adipokine identified from rodents in 2001 is involved in many biological processes. However, little is known about this gene in fish. We cloned Siberian sturgeon ( Acipenser baerii ) resistin cDNA of 795 base pairs, encoding 107 amino acids, which showed 38–40% identity to human and rodents. Real‐time quantitative PCR showed that the resistin gene was widely distributed in tissues of Siberian sturgeon, with the highest expression in liver. After fasting for 1, 3, 6 and 10 days, the expression of the resistin gene in the liver of Siberian sturgeon decreased significantly, and after refeeding on the 10 days of fasting the resistin mRNA expression increased rapidly, suggesting that resistin may play an important role in liver in response to starvation. Taken together, these results suggest that resistin may be involved in the regulation of energy homeostasis in liver.

Isolation and identification of two new compounds from the Penicillium sp. SYPF7381 - Qing-Mei Feng; Xing-Yu Li; Bing-Xin Li; Tian-Yuan Zhang; Hai-Feng Wang; Meng-Yue Zhang; Ying-Ying Wu; Gang Chen; Yi-Xuan Zhang; Yue-Hu Pei (Natural Product Research, 2020)

New Terpenoids And Lignans From The Twigs Of T ripterygium Hypoglaucum - Hui Zheng; Li Wang; Tao Yang; Dan Liu; Hong-Mei Li; Xuan-Qin Chen; Rong-Tao Li (Natural Product Research, 2020)

Targeting Inflammation, PHA-767491 Shows a Broad Spectrum in Protein Aggregation Diseases - Yu-Han Chung; Chia-Wei Lin; Hsin-Yu Huang; Shu-Ling Chen; Hei-Jen Huang; Ying-Chieh Sun; Guan-Chiun Lee; Guey-Jen Lee-Chen; Ya-Ching Chang; Hsiu Mei Hsieh-Li (Journal of Molecular Neuroscience, 2020)

The association between dioxins and steroid hormones in general adult males: a cross-sectional study in an e-waste region of China - Li Li Shi; Mei Qin Wang; Shoji F. Nakayama; Chau-Ren Jung; Yue Hua Wang; Jing Jian Dong; Chao Chen Ma; Teruhiko Kido; Xian Liang Sun; Hao Feng (Environmental Science and Pollution Research, 2020)

Crosstalk between PKC and MAPK pathway activation in cardiac fibroblasts in a rat model of atrial fibrillation - Wei-hua Guo; Xian Wang; Mei-sheng Shang; Zhe Chen; Qi Guo; Li Li; Hai-ying Wang; Rong-hui Yu; Chang-sheng Ma (Biotechnology Letters, 2020)

Evoked-potential audiogram variability in a group of wild Yangtze finless porpoises (Neophocaena asiaeorientalis asiaeorientalis) - Zhi-Tao Wang; Jiao Li; Peng-Xiang Duan; Zhi-Gang Mei; Fu-Qiang Niu; Tomonari Akamatsu; Pei-Yu Lei; Lu Zhou; Jing Yuan; Yu-Wei Chen; Alexander Ya Supin; Ding Wang; et al. (Journal of Comparative Physiology A, 2020)

The role of hepatic cytochrome P450s in the cytotoxicity of sertraline - Si Chen; Qiangen Wu; Xilin Li; Dongying Li; Michelle Fan; Zhen Ren; Matthew Bryant; Nan Mei; Baitang Ning; Lei Guo (Archives of Toxicology, 2020)

Anti-hypertensive effects of Radix Rehmanniae and its active ingredients - Chiu-Haw Chao; Jue-Liang Hsu; Mu-Fen Chen; Ya-Hu Shih; Chia-Hui Lee; Mei-Li Wu; Chi-I Chang (Natural Product Research, 2020)

A new triterpenoid saponin from Pulsatilla cernua predicted by NMR-based mosaic method - An-Dong Wang; Ying Bao; Xia Wang; Mei-Chen Li; Xu-Hong Ren; Jian-Yu Liu; Yong-Nan Xu (Natural Product Research, 2020)

Myelin Deficits Caused by Olig2 Deficiency Lead to Cognitive Dysfunction and Increase Vulnerability to Social Withdrawal in Adult Mice - Xianjun Chen; Fei Wang; Jingli Gan; Zhonghua Zhang; Xuejun Liang; Tao Li; Nanxin Huang; Xiaofeng Zhao; Feng Mei; Lan Xiao (Neuroscience Bulletin, 2020)

High-carbohydrate diet promotes the adaptation to acute hypoxia in zebrafish - Qiang Ma; Chun-Ting Hu; Junjiayu Yue; Yuan Luo; Fang Qiao; Li-Qiao Chen; Mei-Ling Zhang; Zhen-Yu Du (Fish Physiology and Biochemistry, 2020)

An empirical study on energy utilization efficiency, economic development, and sustainable management - Xin-Xin Pan; Mei-Lan Chen; Li-Meng Ying; Fang-Fang Zhang (Environmental Science and Pollution Research, 2020)