Numerical simulation on flow field, wind erosion and sand sedimentation patterns over railway subgrades - Kai Zhang; Li-ming Zhao; Hai-long Zhang; Ao-jun Guo; Bo Yang; Sheng Li (Journal of Mountain Science, 2022)

Siccirubricoccus soli sp. nov., a novel bacterial species isolated from Jiaozi Mountain soil - Guo-Xing Zhu; Ya-Jie Wu; Yan-Ru Cao; Bing-Jun Fan; Yu Jiao; Xiu-Li Hou; Zi-Chao Liu; Yue Zhang; Jiang-Bo He; Lian-Ming Liang (Antonie van Leeuwenhoek, 2022)

Bioconversion of food waste to crayfish feed using solid-state fermentation with yeast - Qinping Li; Puhong Yi; Jianze Zhang; Yudong Shan; Yongfeng Lin; Ming Wu; Kun Wang; Guangming Tian; Ji Li; Tingheng Zhu (Environmental Science and Pollution Research, 2022)

Adsorption properties and mechanism research of phosphorus with different molecular structures from aqueous solutions by La-modified biochar - Ming-yao Yuan; Shang-kai Qiu; Meng-meng Li; Yuan Li; Ji-Xiu Wang; Yuan Luo; Ke-qiang Zhang; Feng Wang (Environmental Science and Pollution Research, 2022)

Cassane diterpenoids from Caesalpinia pulcherrima and their anti-inflammatory and α -glycosidase inhibitory activities - Xin Yun; Xiu-Mei Chen; Jia-Yun Wang; Wang Lu; Zi-Han Zhang; Young Ho Kim; Shi-Chun Zong; Chun-Huan Li; Jin-Ming Gao (Natural Product Research, 2022)

Changes in amino acid and fatty acid composition during early development in cobia (Rachycentron canadum) - Jian-sheng Huang; Rong-xin Li; Rui-tao Xie; You-ming Chen; Jian-dong Zhang; Eric Amenyogbe; Gang Chen (Frontiers in Marine Science, 2022)
An estimation of the utilization of endogenous nutrients from the yolk sac that occurs during embryonic and early larval development can be a valuable approach to studying the nutritional requirements of fish larvae. In this study, fertilized eggs, embryos (before the membrane, 24 hours after fertilization), newly-hatched larvae (0-d-old), and open-mouthed larvae (3-day-old, unfed rotifers) samples of cobia ( Rachycentron canadum ) were collected to determine the amino acid and fatty acid profiles. Crude protein composition varies significantly for cobia during the different stages of development. The total amino acids, except for lysine(Lys), histidine (His), methionine(Met), serine(Ser), and glycine(Gly), had no significant change in the early development stage ( P > 0.05); the content of other six essential amino acids (EAA) and six non-essential amino acids (NEAA) was consistent with the changing trend of total essential amino acid. From hatching newly hatched larvae to open-mouthed larvae, except for Leu, Phe and Ser, decreased significantly ( P <0.05). From the utilization rate of FAA, the utilization rate of Lys and Leu was the highest (60.26%) and (52.21%) in the embryonic and endogenous nutritional stages, respectively. The water content of the open-mouthed larvae of cobia was significantly higher than that of the fertilized eggs, embryos, and newly hatched larvae ( P < 0.05). Three kinds of saturated fatty acids (SFA), five kinds of monounsaturated fatty acids (MUFA), and eight kinds of polyunsaturated fatty acids (PUFA) were detected in the dry samples of each developmental stage. Based on these results, juvenile cobia can thrive with a wide range of crude protein concentrations. Further refinement of commercial cobia production feeds would have beneficial consequences for economic and environmental concerns due to the positive impacts of optimizing the protein component as well as the ability to maintain the rapid growth rates. The results show that the larval development of cobia needs to consume large amounts of n3PUFA (especially DHA and EPA) to improve the larvae’s survival rate. Research methods will always have limitations when evaluating the relationship between early life nutrition interventions and well-being outcomes later in life. This study provides essential information regarding cobia larvae’s fatty acid requirements.

Permian-Triassic magmatic and thermal events in the Dunhuang orogenic belt: implications for subduction records of the Paleo-Asian Ocean - Qian W.L. Zhang; Yi-Chao Chen; Meng-Yan Shi; Zhen M.G. Li; Jia-Hui Liu; Chun-Ming Wu (International Geology Review, 2022)

Pathological Networks Involving Dysmorphic Neurons in Type II Focal Cortical Dysplasia - Yijie Shao; Qianqian Ge; Jiachao Yang; Mi Wang; Yu Zhou; Jin-Xin Guo; Mengyue Zhu; Jiachen Shi; Yiqi Hu; Li Shen; Zhong Chen; Xiao-Ming Li; et al. (Neuroscience Bulletin, 2022)

Deformation behavior and damage-induced permeability evolution of sandy mudstone under triaxial stress - Yang Liu; Tong Zhang; Yankun Ma; Shuaibing Song; Ming Tang; Yanfang Li (Natural Hazards, 2022)

Knockdown of lncRNA MIAT attenuated lipopolysaccharide-induced microglial cells injury by sponging miR-613 - Jia Li; Chang-Lin Zou; Zhi-Ming Zhang; Feng Xue (Mammalian Genome, 2022)

UV-B irradiation and allelopathy by Sargassum thunbergii affects the activities of antioxidant enzymes and their isoenzymes in Corallina pilulifera - Ming Liu; Jiqiang Zhao; Yujuan Pang; Lipei Zhang; Fuhua Bian; Lixia Li (Journal of Oceanology and Limnology, 2022)

Oil pollutant identification based on excitation-emission matrix of UV-induced fluorescence and deep convolutional neural network - Ying Li; Yunpeng Jia; Xiaohua Cai; Ming Xie; Zhenduo Zhang (Environmental Science and Pollution Research, 2022)

Heterogeneous reservoir prediction of ultra-deep strike-slip fault-damaged zone constrained with local seismic anomaly data - Xiangwen Li; Jingye Li; Xukui Feng; Guangjian Dan; Gulan Zhang; Lei Zhang; Ming Zhang; Liangliang Zhang; Hongbo Zhou; Wei Zhao (Earth Science Informatics, 2022)

Novel CRISPR/Cas9-mediated knockout of LIG4 increases efficiency of site-specific integration in Chinese hamster ovary cell line - Chuanjie Wang; Zhaolin Sun; Ming Wang; Zhiyang Jiang; Mengmeng Zhang; Hongxu Cao; Longlong Luo; Chunxia Qiao; He Xiao; Guojiang Chen; Xinying Li; Jinqing Liu; et al. (Biotechnology Letters, 2022)

Comparative genomic analysis of the genus Marinomonas and taxonomic study of Marinomonas algarum sp. nov., isolated from red algae Gelidium amansii - Jian-Heng Xue; Bei-Ning Zhang; Feng Zhang; Ying-Ying Liu; Wen-Jie Wu; Zhao-Ming Wu; Yue Si; Peng-Xi Yang; Xiang Xing; Li-Hua Zhao (Archives of Microbiology, 2022)

Spatial variation in bacterial community and dissolved organic matter composition in groundwater near a eutrophic lake - Ning Ma; Li Gao; Yan Zhang; Zhengkui Ge; En Hu; Baozhu Pan; Jian Wang; Ming Li (Aquatic Ecology, 2022)

Petrophysical characteristics of shale oil reservoirs in the Yanchang Formation, Ordos Basin - Si-Xin Zhu; Li-Ming An; Yong-Kang Li; Xiao-Dong Zhang; Fan-Ke Meng (Applied Geophysics, 2022)

Ancylostoma ceylanicum Infection in a Miniature Schnauzer Dog Breed - Xu-Hui Lin; Hai-Ming Cai; Zhuan-Qiang Yan; Shen-Quan Liao; Min-Na Lv; Cai-Yan Wu; Juan Li; Jun-Jing Hu; Wen-Wan Xiao; Jian-Fei Zhang; Nan-Shan Qi; Ming-Fei Sun (Acta Parasitologica, 2022)

Fried-food consumption and risk of overweight/obesity, type 2 diabetes mellitus, and hypertension in adults: a meta-analysis of observational studies - Pei Qin; Dechen Liu; Xiaoyan Wu; Yunhong Zeng; Xizhuo Sun; Yanyan Zhang; Yang Li; Yuying Wu; Minghui Han; Ranran Qie; Shengbing Huang; Yang Zhao; et al. (Critical Reviews in Food Science and Nutrition, 2022)

Investigation of the 2019 Wenchuan County debris flow disaster suggests nonuniform spatial and temporal post-seismic debris flow evolution patterns - Xianzheng Zhang; Chenxiao Tang; Ning Li; Jiang Xiong; Ming Chen; Mingwei Li; Chuan Tang (Landslides, 2022)

Role of host plants in the suitability and dispersal of an omnivorous predator Arma chinensis Fallou (Hemiptera: Pentatomidae: Asopinae) in a biological control context - Ming-Zhen Pan; Zhi-Xiao Fu; Yu-Yan Li; Hong-Yin Chen; Li-Sheng Zhang; Tong-Xian Liu (Journal of Plant Diseases and Protection, 2022)

Ketone Body Rescued Seizure Behavior of LRP1 Deficiency in Drosophila by Modulating Glutamate Transport - Jin-Ming Zhang; Ming-Jie Chen; Jiong-Hui He; Ya-Ping Li; Zhi-Cai Li; Zi-Jing Ye; Yong-Hui Bao; Bing-Jun Huang; Wen-Jie Zhang; Ping Kwan; Yu-Ling Mao; Jing-da Qiao (Journal of Molecular Neuroscience, 2022)

Modification effects of seasonal and temperature variation on the association between exposure to nitrogen dioxide and ischemic stroke onset in Shenzhen, China - Yuchen Tian; Ming Xiang; Ji Peng; Yanran Duan; Ying Wen; Suli Huang; Lei Li; Shuyuan Yu; Jinquan Cheng; Xia Zhang; Peng Wang (International Journal of Biometeorology, 2022)

Effects of Cinnamomum camphora Leaves Extracts-Flocculants Composite Algaecide on Microcystis aeruginosa Growth and Microcystins Release - Han-yun Li; Yin-dong Ye; Qi-jun Zhang; Cun-hao Du; Hui-ming Li; Li Yin (Bulletin of Environmental Contamination and Toxicology, 2022)

Lead Exposure in Developmental Ages Promotes Aβ Accumulation by Disturbing Aβ Transportation in Blood-Cerebrospinal Fluid Barrier/Blood–Brain Barriers and Impairing Aβ Clearance in the Liver - Can-Can Zhou; Xu-Jie Wang; Zi-Chen Li; Wen-Jie Lu; Yun-Ting Zhang; Fu-Ming Shen; Dong-Jie Li (Biological Trace Element Research, 2022)

Nematicidal activity of volatile organic compounds produced by Bacillus altitudinis AMCC 1040 against Meloidogyne incognita - Lin Ye; Jian-Yu Wang; Xiao-Fang Liu; Qi Guan; Nong-Xiao Dou; Jian Li; Qian Zhang; Yan-Ming Gao; Min Wang; Jian-She Li; Bo Zhou (Archives of Microbiology, 2022)

Cohnella mopanensis sp. nov., a new Gram-negative bacterium isolated from soil in Xinping Mountain National Forest Park - Jing Tang; Jiang-Yuan Zhao; Le-Le Li; Zhang-Gui Ding; Shi-Qiang Ye; Cheng Ling; Meng-Yu Zhang; Song-Guo Liang; Jian-Yu Li; Pei-Wen Yang; Jiao Xiong; Lu-Yao Feng; et al. (Archives of Microbiology, 2022)

Systematic contributions of CFEM domain‐containing proteins to iron acquisition are essential for interspecies interaction of the filamentous pathogenic fungus Beauveria bassiana - Yue‐Jin Peng; Jia Hou; Hao Zhang; Jia‐Hui Lei; Hai‐Yan Lin; Jin‐Li Ding; Ming‐Guang Feng; Sheng‐Hua Ying (Environmental Microbiology, 2022)
Summary Common in fungal extracellular membrane (CFEM) domain is unique in fungal proteins and some of which contribute to iron acquisition in yeast. However, their roles in iron acquisition remain largely unknown in filamentous fungi. In this study, 12 CFEM‐containing proteins were bioinformatically identified in the filamentous entomopathogenic fungus Beauveria bassiana , and the roles of 11 genes were genetically characterized. Transmembrane helices were critical for their association with intracellular membranes, and their number varied among proteins. Eleven CFEM genes significantly contribute to vegetative growth under iron starvation and virulence. Notably, the virulence of most disruptants could be significantly weakened by a decrease in iron availability, in which the virulence of Δ Bbcfem7 and 8 strains was partially recovered by exogenous hemin. Δ Bbcfem7 and 8 mutants displayed defective competitiveness against the sister entomopathogenic fungus Beauveria brongniartii . All 11 disruptants displayed impaired growth in the antagonistic assay with the saprotrophic fungus Aspergillus niger , which could be repressed by exogenous ferric ions. These findings not only reveal the systematic contributions of CFEM proteins to acquire two forms of iron (i.e. heme and ferric ion) in the entire lifecycle of entomopathogenic fungi but also help to better understand the mechanisms of fungus–host and inter–fungus interactions.

Improving protected area effectiveness through consideration of different human‐pressure baselines - Chun‐Ting Feng; Ming Cao; Fang‐Zheng Liu; Yue Zhou; Jin‐Hong Du; Li‐Bo Zhang; Wen‐Jie Huang; Jian‐Wu Luo; Jun‐Sheng Li; Wei Wang (Conservation Biology, 2022)
Previous assessments of the effectiveness of protected areas (PAs) focused primarily on changes in human pressure over time and did not consider the different human‐pressure baselines of PAs, thereby potentially over‐ or underestimating PA effectiveness. We developed a framework that considers both human‐pressure baseline and change in human pressure over time and assessed the effectiveness of 338 PAs in China from 2010 to 2020. The initial state of human pressure on PAs was taken as the baseline, and changes in human pressure index (HPI) were further analyzed under different baselines. We used the random forest models to identify the management measures that most improved effectiveness in resisting human pressure for the PAs with different baselines. Finally, the relationships between the changes in the HPI and the changes in natural ecosystems in PAs were analyzed with different baselines. Of PAs with low HPI baselines, medium HPI baselines, and high HPI baselines, 76.92% ( n =150), 11.11% ( n =12), and 22.86% ( n =8) , respectively, showed positive effects in resisting human pressure. Overall, ignoring human‐pressure baselines somewhat underestimated the positive effects of PAs, especially for those with low initial human pressure. For PAs with different initial human pressures, different management measures should be taken to improve effectiveness and reduce threats to natural ecosystems. We believe our framework is useful for assessing the effectiveness of PAs globally, and we recommend it be included in the Convention on Biological Diversity Post‐2020 Strategy.

The fate of flavonoids after oral administration: a comprehensive overview of its bioavailability - Abid Naeem; Yang Ming; Hu Pengyi; Kang Yong Jie; Liu Yali; Zhang Haiyan; Xiao Shuai; Li Wenjing; Wu Ling; Zhang Ming Xia; Liu Shan Shan; Zheng Qin (Critical Reviews in Food Science and Nutrition, 2022)

Spatial-temporal distribution and tectonic setting of Mesozoic W-mineralized granitoids in the Xing-Meng Orogenic Belt, NE China - Wei Xie; Qing-Dong Zeng; Rui-Liang Wang; Jin-Jian Wu; Zhe-Ming Zhang; Feng-Chun Li; Zhuang Zhang (International Geology Review, 2022)

Correction to: Matrine Treatment Blocks NogoA-Induced Neural Inhibitory Signaling Pathway in Ongoing Experimental Autoimmune Encephalomyelitis - Quan-Cheng Kan; Hui-Jun Zhang; Yuan Zhang; Xing Li; Yu-Ming Xu; Rodolfo Thome; Ming-Liang Zhang; Nan Liu; Yao-Juan Chu; Guang-Xian Zhang; Lin Zhu (Molecular Neurobiology, 2022)

Transport of anatase and rutile titanium dioxide nanoparticles in soils in the presence of phosphate: mechanisms and numerical modeling - Li Yang; Ming Chen; Dapeng Li; Nan Xu; Jianping Chen; Dongsheng Zhang (Journal of Soils and Sediments, 2022)

Chloride-binding capacity of mortars composed of marine sand subjected to external chloride penetration - Congtao Sun; Ming Sun; Tao Tao; Feng Qu; Gongxun Wang; Peng Zhang; Yantao Li; Jizhou Duan (Journal of Oceanology and Limnology, 2022)

RIG-I acts as a tumor suppressor in melanoma via regulating the activation of the MKK/p38MAPK signaling pathway - Rui Guo; Shun-Yuan Lu; Jin-Xia Ma; Qian-Lan Wang; Lu Zhang; Ling-Yun Tang; Yan Shen; Chun-Ling Shen; Jin-Jin Wang; Li-Ming Lu; Zhu-Gang Wang; Hong-Xin Zhang (Human Cell, 2022)
Studies have indicated that RIG-I may act as a tumor suppressor and participate in the tumorigenesis of some malignant diseases. However, RIG-I induces distinct cellular responses via different downstream signaling pathways depending on the cell type. To investigate the biological function and underlying molecular mechanism of RIG-I in the tumorigenesis of melanoma, we constructed RIG-I knockout, RIG-I -overexpressing B16-F10 and RIG-I knockdown A375 melanoma cell lines, and analyzed the RIG-I-mediated change in the biological behavior of tumor cells in spontaneous and poly (I:C)-induced RIG-I activation. Cell proliferation, cell cycling, apoptosis and migration were detected by CCK-8 assay, BrdU incorporation assay, Annexin V–PI staining assay and Transwell assay, respectively. In vivo tumorigenicity was evaluated by tumor xenograft growth in nude mice and subsequently by Ki67 staining and TUNEL assays. Furthermore, Western blotting was utilized to explore the underlying mechanism of RIG-I in melanoma cells. Our data showed that RIG-I promotes apoptosis and inhibits proliferation by G1 phase cell cycle arrest in the melanoma cell lines. Mechanistically, RIG-I induced the phosphorylation of p38 MAPK and MAPK kinases MKK3 and MKK4. In conclusion, the current study demonstrated that RIG-I suppressed the development of melanoma by regulating the activity of the MKK/p38 MAPK signaling pathway, which is relevant to research on novel therapeutic targets for this malignant disease.

Testing the transfer functions for the Geonor T-200B and Chinese standard precipitation gauge in the central Qinghai—Tibet Plateau - Le-le Zhang; Li-ming Gao; Ji Chen; Lin Zhao; Ke-long Chen; Jing-yi Zhao; Guo-jun Liu; Ting-xi Song; Yan-kun Li (Journal of Mountain Science, 2022)

Diversity and Structure of Demersal Fish Community Over the Northern Slope in the South China Sea - Jun Zhang; Kui Zhang; Yan-e Jiang; Yuan-jie Li; Jiang-tao Fan; Wen-ming Yu; Zuo-zhi Chen (Frontiers in Marine Science, 2022)
Three bottom trawl surveys over the northern continental slope in the South China Sea (18°50′–20°40′N, 112°50′–115°10′E) were carried out, in June 2015, March 2017 and September 2018, to investigate species composition, biodiversity and community structure of demersal fish. Surveys in 2015, 2017 and 2018 captured 97 fish species (representing 77 genera, 52 families, 26 orders), 108 fish species (representing 84 genera, 61 families, 19 orders) and 126 fish species (representing 105 genera, 74 families, 25 orders), respectively. Three surveys captured a total of 252 fish species, representing 164 genera, 97 families, 30 orders. Perciformes dominated. Species richness in station linking shallow continental shelf with deep slope was the lowest among stations. In three surveys, 16 species occurred in the catches of three surveys, accounting for 6.35% of all species. Species replacement rate between stations showed a significant linear relationship with the depth difference and latitude difference. Margalef’s species richness index ( D ), Shannon–Weiner diversity index ( H’ ) and Pielou’s evenness index ( J’ ) among stations ranged 2.65–6.74, 1.02–4.15 and 0.28–1.14, respectively. Differences of D , H ’ and J ’ were insignificant among seasons. There were significant positive linear relations between H’ and J’ and latitude. D , H’ and J’ decreased with increasing sampling depth, however the relations were not significant. Based on multivariate statistical analysis, fish community at species level was divided into five groups with average dissimilarities of 95.69%–99.96%. In terms of genus and family, average dissimilarities among groups were more than 88.11% and 82.69%. There were significant differences in species composition between depths, but no significant differences between seasons and temperatures, as well as in genus and family composition.

Otolith Marking With Strontium for Stock Assessment in Coilia nasus - Ming-Zhi Liu; Ri-jin Jiang; Hui Zhang; Fan Yang; Xia-Fang Li; Guang-Peng Feng; Rui Yin; Feng Chen (Frontiers in Marine Science, 2022)
Mass stock enhancement and release are excellent ways to recover Coilia nasus resources. However, it is challenging to evaluate stock enhancement effectively, and it is important to establish a method suitable for estimating C. nasus populations. We explored the effectiveness of marking otoliths in these fish with strontium by immersing C. nasus in hexahydrate strontium chloride solutions. We used laser ablation inductively coupled plasma mass spectrometry to measure the strontium content of otoliths and fish bodies. The larvae (40 d post hatch) were reared in five different concentrations of strontium (0, 12, 24, 48, and 60 mg/L) for 7 d, followed by treatment in non-additive water for 3 wk. The results showed that the cumulative mortality rate was not significantly different between treatment and control groups ( P >0.05), except in the group treated with 24 mg/L strontium. The swimming and feeding behaviors did not change significantly, indicating that strontium did not negatively affect survival in this species. The strontium/calcium ratios of otoliths in the control group were stable (1.78–2.32 mmol/mol), whereas those of the experimental (marked) groups ranged widely (4.47–61.02 mmol/mol). The strontium/calcium ratios increased with increasing strontium concentration, but gradually returned to baseline values, resulting in a 100% success rate of marking with strontium. Following immersion in 12 mg/L strontium, strontium levels in the body returned to normal after 24 d. In summary, a treatment of 12 mg/L strontium for 4 d was identified as viable for marking. We confirmed the feasibility of strontium marking for the mass marking and release of C. nasus . This marking method does not affect the physiology of the fish and may provide a new approach for reasonable and scientific stock assessment of C. nasus post hatch.

Effects of secondary succession on soil fungal and bacterial compositions and diversities in a karst area - Genzhu Wang; Yuguo Liu; Ming Cui; Ziyuan Zhou; Qian Zhang; Yajin Li; Wenxiu Ha; Danbo Pang; Jiufu Luo; Jinxing Zhou (Plant and Soil, 2022)

Therapeutic Effects of Sodium Para-Aminosalicylic Acid on Cognitive Deficits and Activated ERK1/2-p90RSK/NF-κB Inflammatory Pathway in Pb-Exposed Rats - Li-li Lu; Yu-wen Zhang; Zhao-cong Li; Yuan-yuan Fang; Lei-lei Wang; Yue-song Zhao; Shao-jun Li; Shi-yan Ou; Michael Aschner; Yue-ming Jiang (Biological Trace Element Research, 2022)

Characterization and Functional Explorations of O-glycosylation Enzymes SECRET AGENT and SPINDLY in Pyrus bretschneideri - Hongru Gao; Qiuping Tan; Qionghou Li; Guodong Chen; Chao Tang; Peng Cao; Ming Qian; Mingliang Zhang; Peng Wang; Shaoling Zhang; Juyou Wu (Journal of Plant Biology, 2022)

Comparison of different inversion methods of D-T2 two-dimensional nuclear magnetic resonance logging and applicability analysis - Cheng-Lin Li; Mao-Jin Tan; Ke-Wen Wang; Feng Zhou; Ying-Ming Liu; Hai-Tao Zhang; Li-Zhi Xiao (Applied Geophysics, 2022)

Arbuscular mycorrhizal fungal colonization improves growth, photosynthesis, and ROS regulation of split-root poplar under drought stress - Haoqiang Zhang; Li Li; Wei Ren; Wenrui Zhang; Ming Tang; Hui Chen (Acta Physiologiae Plantarum, 2022)

A new highly oxygenated germacranolide from Carpesium nepalense var. lanatum (C.B.Clarke) Kitam - Yi-Fan Yu; Yue-Qian Li; Ru-Yue Wang; Xu Liu; Wen-Bo Cui; Xiao-Han Chen; Cheng-Mu Zhao; Feng-Ming Qi; Zhan-Xin Zhang; Dong-Qing Fei (Natural Product Research, 2022)

Characteristics of the TDRD1 gene promoter in chickens - Xiaomin Gao; Xiaolin Sun; Pei Xu; Xiang Shi; Ming Zhang; Xia Yuan; Jingyi Jiang; Kai Jin; Qisheng Zuo; Yani Zhang; Bichun Li (Molecular Genetics and Genomics, 2022)

Identification and management of GCK-MODY complicating pregnancy in Chinese patients with gestational diabetes - Yanyan Jiang; Fusong Jiang; Ming Li; Qingkai Wu; Chenming Xu; Rong Zhang; Mingqiang Song; Yanzhong Wang; Ying Wang; Yating Chen; Juan Zhang; Xiaoxu Ge; et al. (Molecular and Cellular Biochemistry, 2022)

The Effects of Ground and Treadmill Running on Energy Metabolism and Muscle Contractile Properties: A Randomized Cross-Over Study - Yuan Zhou; Jian-gang Chen; Xiao-long Li; Xin-liang Pan; Yi-zheng Zhou; Zheng-ao Li; Zhi-cheng Liang; Jia-min Long; Ming-ze Qin; Jing Zhang; Bing Shi; Bing-jun Wan; et al. (Journal of Science in Sport and Exercise, 2022)
Purpose This study aimed to compare the effects of ground and treadmill running on energy metabolism and muscle contractile properties, providing a basis for the general public to choose running venues. Methods Ten male college students (age, 20.10 ± 1.53 years; height, 176.20 ± 5.49 cm; weight, 72.14 ± 8.25 kg; body fat percent, 12.41% ± 4.65%) were recruited in this study. Energy expenditure (EE) was measured using the accelerometer (GT9X) combined with specific estimation equations. Average heart rate (HR) was measured using a heart rate band (Polar). Muscle contractile properties were assessed by measuring muscle displacement (Dm) and contraction velocity (Vc) using tensiomyography (TMG-S1). Blood glucose (Glu) and lactate (Lac) were measured by portable devices (eB-G and Lactate Scout). The running speed was 9 km/h and the duration was 25 min. Two-way ANOVA (protocol × time) was used to analyze the effect of running protocols on energy metabolism and muscle contractile properties. Results EE of treadmill running was significantly higher than EE of ground running (protocol main effect, P < 0.001), and HR of treadmill running was significantly higher than that of ground running in the first testing time (protocol simple effect, P = 0.026; protocol × time interaction P = 0.043). The decrease in Dm of the rectus femoris after treadmill running was significantly higher than that of ground running (protocol main effect, P = 0.009). The interaction of different running protocols and testing times on Lac was significant ( P = 0.025), but all results of the simple effects analysis were not statistically significant ( P > 0.05). Conclusion Our study found a difference in energy expenditure between treadmill and ground running at 9 km/h with duration of 25 min. In addition, treadmills are more likely to cause a decrease in muscle displacement distance of the rectus femoris measured after exercise than ground running. Future studies are needed to further investigate whether the differences are induced by internal metabolism or the environmental conditions of running.

Transcriptome revealing the dual regulatory mechanism of ethylene on the rhynchophylline and isorhynchophylline in Uncaria rhynchophylla - Xue Li; Xiao-hong Wang; Wei Qiang; Hao-jie Zheng; Li-yang ShangGuan; Ming-sheng Zhang (Journal of Plant Research, 2022)

Metagenomic insights into the environmental adaptation and metabolism of Candidatus Haloplasmatales, one archaeal order thriving in saline lakes - Heng Zhou; Dahe Zhao; Shengjie Zhang; Qiong Xue; Manqi Zhang; Haiying Yu; Jian Zhou; Ming Li; Sumit Kumar; Hua Xiang (Environmental Microbiology, 2022)
Summary The KTK 4A‐related Thermoplasmata thrives in the sediment of saline lakes; however, systematic research on its taxonomy, environmental adaptation and metabolism is lacking. Here, we detected this abundant lineage in the sediment of five artificially separated ponds (salinity 7.0%–33.0%) within a Chinese soda‐saline lake using culture‐independent metagenomics and archaeal 16S rRNA gene amplicons. The phylogenies based on the 16S rRNA gene, and 122 archaeal ubiquitous single‐copy proteins and genome‐level identity analyses among the metagenome‐assembled genomes demonstrate this lineage forming a novel order, Candidatus Haloplasmatales, comprising four genera affiliated with the identical family. Isoelectric point profiles of predicted proteomes suggest that most members adopt the energetically favourable ‘salt‐in’ strategy. Functional prediction indicates the lithoheterotrophic nature with the versatile metabolic potentials for carbohydrate and organic acids as well as carbon monoxide and hydrogen utilization. Additionally, hydrogenase genes hdrABC ‐ mvhADG are linked with incomplete reductive citrate cycle genes in the genomes, suggesting their functional connection. Comparison with the coupling of HdrABC‐MvhADG and methanogenesis pathway provides new insights into the compatibility of laterally acquired methanogenesis with energy metabolism in the related order Methanomassiliicoccales . Globally, our research sheds light on the taxonomy, environmental adaptative mechanisms, metabolic potentials and evolutional significance of Ca . Haloplasmatales.

Phenotypic plasticity of light use favors a plant invader in nitrogen‐enriched ecosystems - Xiao Xu; Chenhao Zhou; Qiang He; Shiyun Qiu; Yan Zhang; Ji Yang; Bo Li; Ming Nie (Ecology, 2022)
Eutrophication is believed to promote plant invasion, resulting in high growth performances of invasive plants and, therefore, the great potential for growth‐induced intraspecific competition for light. Current hypotheses predict how eutrophication promotes plant invasion but fail to explain how great invasiveness is maintained under eutrophic conditions. In diverse native communities, co‐occurring plants of varying sizes can avoid light competition by exploiting light complementarily; however, whether this mechanism applies to intraspecific competition in invasive plant populations remains unknown. Using a 2‐year field nitrogen (N)‐enrichment experiment on one of the global invasive plants, Spartina alterniflora , we found that the plasticity of light use reduced intraspecific competition and increased biomass production in S. alterniflora . This plasticity effect was enhanced when S. alterniflora had no nutrient limitations. In the N‐enrichment treatments, the height difference among S. alterniflora ramets increased as light intensity decreased under the canopy. Compared with ambient N, under N enrichment, shorter individuals increased their light‐use efficiency and specific leaf area in response to the reduced light intensity under the canopy. However, such ecophysiological plasticity was not found for taller individuals. Our findings revealed that the light‐use plasticity of short individuals can be envisaged as a novel mechanism by which an invasive plant alleviates intraspecific competition and increases its invasiveness, challenging the prevailing perspective that the invasiveness of exotic plants is constrained by intraspecific competition.

Quinolizidine alkaloids from the roots of Sophora flavescens - Jian-Chun Li; Zhi-Jun Zhang; Dan Liu; Ming-Yan Jiang; Rong-Tao Li; Hong-Mei Li (Natural Product Research, 2022)

Distinct co-occurrence patterns and driving forces of abundant and rare bacterial communities in the multispecies solid-state fermentation process of cereal vinegar - Ming-Ye Peng; Zhen-Ming Lu; Xiao-Juan Zhang; Ting Huang; Yong-Jian Deng; Li-Juan Chai; Jin-Song Shi; Zheng-Hong Xu (Systems Microbiology and Biomanufacturing, 2022)

Anterior Cingulate Cortex Mediates Hyperalgesia and Anxiety Induced by Chronic Pancreatitis in Rats - Dan Ren; Jia-Ni Li; Xin-Tong Qiu; Fa-Ping Wan; Zhen-Yu Wu; Bo-Yuan Fan; Ming-Ming Zhang; Tao Chen; Hui Li; Yang Bai; Yun-Qing Li (Neuroscience Bulletin, 2022)
Central sensitization is essential in maintaining chronic pain induced by chronic pancreatitis (CP), but cortical modulation of painful CP remains elusive. Here, we examined the role of the anterior cingulate cortex (ACC) in the pathogenesis of abdominal hyperalgesia in a rat model of CP induced by intraductal administration of trinitrobenzene sulfonic acid (TNBS). TNBS treatment resulted in long-term abdominal hyperalgesia and anxiety in rats. Morphological data indicated that painful CP induced a significant increase in FOS-expressing neurons in the nucleus tractus solitarii (NTS) and ACC, and some FOS-expressing neurons in the NTS projected to the ACC. In addition, a larger portion of ascending fibers from the NTS innervated pyramidal neurons, the neural subpopulation primarily expressing FOS under the condition of painful CP, rather than GABAergic neurons within the ACC. CP rats showed increased expression of vesicular glutamate transporter 1, and increased membrane trafficking and phosphorylation of the N -methyl-D-aspartate receptor (NMDAR) subunit NR2B and the α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor (AMPAR) subunit GluR1 within the ACC. Microinjection of NMDAR and AMPAR antagonists into the ACC to block excitatory synaptic transmission significantly attenuated abdominal hyperalgesia in CP rats, which was similar to the analgesic effect of endomorphins injected into the ACC. Specifically inhibiting the excitability of ACC pyramidal cells via chemogenetics reduced both hyperalgesia and comorbid anxiety, whereas activating these neurons via optogenetics failed to aggravate hyperalgesia and anxiety in CP rats. Taken together, these findings provide neurocircuit, biochemical, and behavioral evidence for involvement of the ACC in hyperalgesia and anxiety in CP rats, as well as novel insights into the cortical modulation of painful CP, and highlights the ACC as a potential target for neuromodulatory interventions in the treatment of painful CP.

Altered Connectedness of the Brain Chronnectome During the Progression to Alzheimer’s Disease - Maryam Ghanbari; Zhen Zhou; Li-Ming Hsu; Ying Han; Yu Sun; Pew-Thian Yap; Han Zhang; Dinggang Shen (Neuroinformatics, 2022)

Effects of polystyrene microplastics on copper toxicity to the protozoan Euglena gracilis: emphasis on different evaluation methods, photosynthesis, and metal accumulation - Xiuling Li; Zhengjun Wang; Ming Bai; Zhehua Chen; Gan Gu; Xi Li; Changwei Hu; Xuezhen Zhang (Environmental Science and Pollution Research, 2022)

Simultaneous removal of hydrogen sulfide and ammonia in the gas phase: a review - Qi Jiang; Tianguo Li; Yongmei He; Yonglin Wu; Jilai Zhang; Ming Jiang (Environmental Chemistry Letters, 2022)

Focal white matter microstructural alteration after anthracycline-based systemic treatment in long-term breast cancer survivors: a structural magnetic resonance imaging study - Huawen Zhang; Peng Li; Tonghui Liu; Xueyuan Wang; Wei Feng; Rui Chen; Hengyang Wei; Guoqiang Li; Long Ning; Ming Zhang; Yuchen Zhang (Brain Imaging and Behavior, 2022)

Cyclic strain development of clay under traffic loading in Shenzhen, China - Jianfei Ma; Xiangquan Li; Jinqiu Li; Zhenxing Wang; Zhanxue Bai; Chunchao Zhang; Ming Gao (Arabian Journal of Geosciences, 2022)

Thermal adaptation occurs in the respiration and growth of widely distributed bacteria - Weitao Tian; Huimin Sun; Yan Zhang; Jianjun Xu; Jia Yao; Jinquan Li; Bo Li; Ming Nie (Global Change Biology, 2022)
Soil microbial respiration is an important factor in regulating carbon (C) exchange between the soil and atmosphere. Thermal adaptation of soil microorganisms will lead to a weakening of the positive feedback between climate warming and soil respiration. The thermal adaptation of microbial communities and fungal species has been proven. However, studies on the thermal adaptation of bacterial species, the most important decomposers in the soil, are still lacking. Here, we isolated six species of widely distributed dominant bacteria and studied the effects of constant warming and temperature fluctuations on those species. The results showed that constant warming caused a downregulation of respiratory temperature sensitivity ( Q 10 ) of the bacterial species, accompanied by an elevation of the minimum temperature ( T min ) required for growth. Similar results were seen with the addition of temperature fluctuations, suggesting that both scenarios caused a significant thermal adaptation among the bacterial species. Fluctuating and increasing temperatures are considered an important component of future warming. Therefore, the inclusion of physiological responses of bacteria to these changes is essential to understand relationships between microbiota and temperature and enhance the prediction of global soil–atmosphere C feedbacks.

Assessing the impacts of natural disasters on rice production in Jiangxi, China - Xiao Fu; Guannan Zhao; Weicheng Wu; Bin Xu; Jie Li; Xiaoting Zhou; Xinxin Ke; Yuan Li; Wenjing Li; Cuimin Zhou; Jingheng Jiang; Ming Zhang; et al. (International Journal of Remote Sensing, 2022)

Expert Knowledge-Driven Bayesian Network Modeling for Marine Disaster Assessment Under the Small Sample Condition - Ming Li; Ren Zhang; Kefeng Liu (Frontiers in Marine Science, 2022)
Risk assessment and management of marine disasters are the prerequisite of ocean exploitation and utilization. Marine disaster assessment is a complicated system engineering with high non-linearity and uncertainty. To deal with the problem, Bayesian network (BN) has become a powerful model used for disaster assessment due to its capability of expressing complex relationships and reasoning with uncertainty. However, scarce data sets and case samples of marine disasters pose an obstacle to BN modeling, particularly for structure and parameter learning. In our research, we combine expert knowledge with small sample to propose a new BN-based assessment model. Expert knowledge is regularly expressed and quantitatively incorporated into BN learning with DS evidence theory. Then, the genetic algorithm is adopted to search the optimal network parameters. Comparative experiments show that the new model has a better assessment accuracy (91.03%) than BPNN (61.34%) and SVM (70.67%), especially with small samples. The proposed model achieves the risk assessment of marine disasters under the small sample condition, providing the technical support for marine disaster prevention and mitigation.

Transcriptomic analyses reveal the effect of nitric oxide on the lateral root development and growth of mangrove plant Kandelia obovata - Ming-Yue Wei; Huan Li; You-Hui Zhong; Zhi-Jun Shen; Dong-Na Ma; Chang-Hao Gao; Yi-Ling Liu; Wen-Hua Wang; Jing-Ya Zhang; Yan-Ping You; Hai-Lei Zheng (Plant and Soil, 2022)

Vermicompost Application Enhances Halophyte Suaeda salsa Performance and Improves Coastal Saline Soil Quality - Jing-Fang Cai; Xuan-Shao Liu; Kai Sun; Fan Jiang; Ming-Xiang Zhang; Hong-Li Li; Fei-Hai Yu (Journal of Soil Science and Plant Nutrition, 2022)

Study on the impact of comprehensive urbanization on urban civil building CO2 emissions in China - Rong Guo; Nan Li; Hailin Mu; Ming Zhang; Xiyue Yang; Yixuan Han; Rongkang Yao; Zhihao Shao (Environmental Science and Pollution Research, 2022)

Mechanical characteristic and microstructure of salt-rich cement soil - Hao Zhang; Hao-feng Xing; Hao-ming Li (Bulletin of Engineering Geology and the Environment, 2022)

Study on the Effect of Spray Drying Process on the Quality of Microalgal Biomass: a Comprehensive Biocomposition Analysis of Spray-Dried S. acuminatus Biomass - Haiyang Zhang; Ting Gong; Jing Li; Bo Pan; Qiang Hu; Ming Duan; Xuezhi Zhang (BioEnergy Research, 2022)

Structure and stability analysis of antibacterial substance produced by selenium enriched Bacillus cereus BC1 - Shanxiu Ming; Xujun Chen; Na Zhang; Shuyi Li; Zhenzhou Zhu; Shuiyuan Cheng (Archives of Microbiology, 2022)

Caldalkalibacillus salinus sp. nov., isolated from a salt lake in Xinjiang, northwest China - Ting-Hao Ouyang; Man Peng; Zhen Zhang; Wei-Xun Chunyu; Li-Ming Wang; En-Min Zhou; Xu-Hong Gao; Shu-Kun Tang (Archives of Microbiology, 2022)

Microseismic signal denoising by combining variational mode decomposition with permutation entropy - Zhang Xing-Li; Cao Lian-Yue; Chen Yan; Jia Rui-Sheng; Lu Xin-Ming (Applied Geophysics, 2022)

Corrigendum: Pigmentibacter ruber gen. nov., sp. nov., a novel bacterium of the family Silvanigrellaceae isolated from human blood - Na Peng; Wen Xu; Hai-Min Luo; Peng-Wen Ouyang; Bin Jiang; Zhi-Hua Zhang; You-De Cao; Li-Ming Tan; Ping-Hua Qu; Liang-Yi Xie (Antonie van Leeuwenhoek, 2022)

A New Species of Paradiplozoon (Monogenea: Diplozoidae), A Gill Parasite of the Schizothorax Fish (Cyprinidae: Schizothoracinae) from the Yarkand River, Xinjiang, China - Kadirden Arken; Cui-Lan Hao; Ai-Ming Guo; Wen-Run Zhang; Meng-Jie Rong; Wuljan Kamal; Sheng-Li Tian; Munira Kadir; Cheng Yue (Acta Parasitologica, 2022)

Making of Massoia Lactone-Loaded and Food-Grade Nanoemulsions and Their Bioactivities against a Pathogenic Yeast - Li Yuan; Hong-Qian Zhang; Zhe Chi; Guang-Lei Liu; Zhen-Ming Chi (Journal of Marine Science and Engineering, 2022)
Nanoemulsions (NEs) have been made for improving the delivery and disperse of bioactive compounds. In this study, it was found that the best ingredients for the stable Massoia lactone-loaded and food-grade NEs making were 560.0 µL of Tween-80, 240.0 µL of Span-80 and 200.0 µL of Massoia lactone. Then, 9.0 mL of distilled water was titrated into the mixture under continuous magnetic stirring (750 rotations min−1) with about 2 drops per second for 20 min. Finally, the system was treated by ultrasonication using an ultrasonic generator (180 W and 22 KHz) for 5 min. All the prepared particles with a mean droplet diameter of 43 nm were spherical, had uniform size distribution and were equally distributed in the Massoia lactone-loaded NEs. The obtained Massoia lactone-loaded nanoemulsions (NEs) were very stable without changes of the mean droplet diameter and polydispersity indexes (PDI) for over two months under different conditions. As with free Massoia lactone, Massoia lactone loaded in the NEs had high anti-fungal activity against Metschnikowia bicuspidate LIAO, a pathogenic yeast causing milky disease in the Chinese mitten crab by damaging its cell membrane and causing cellular necrosis. Massoia lactone loaded in the NEs also had the DPPH radical scavenging activity and the hydroxyl radical scavenging activity.

Native herbivores indirectly facilitate the growth of invasive Spartina in a eutrophic saltmarsh - Xiao Xu; Yan Zhang; Songshuo Li; Hongyang Chen; Mu Liu; Bo Li; Ming Nie (Ecology, 2022)
Current theory (e.g., consumer‐controlled theory) predicts that nutrient enrichment typically amplifies herbivory and thereby suppresses the growth and expansion of invasive plants. Herbivores can facilitate plant regrowth in the native community by stimulating complementary growth or ameliorating habitat conditions (e.g., by increasing soil oxygen and nutrient availability), but whether they have similar positive effects on invasive plants, especially under nutrient enrichment, remains unknown. Using a field nitrogen (N)‐enrichment × crab exclusion experiment, we evaluated and compared the effects of both N enrichment and crab herbivory on the growth performance of a global invasive cordgrass, Spartina alterniflora , and a co‐occurring native plant, Phragmites australis . We found that crabs consistently suppressed P. australis by density and aboveground biomass regardless of N enrichment. In contrast, for S. alterniflora , the negative effects of crabs under ambient N were replaced by positive effects under N enrichment, with crabs stimulating complementary increases in density and aboveground biomass. The differing effects between the N treatments were driven by crab burrowing activity, which increased soil N availability, and the nutrient‐use efficiency of S. alterniflora . Our findings revealed that native herbivores can have opposing effects on native and invasive plants, which broadens our understanding of how exotic plants can achieve dominance in a changing world.

A peptide encoding gene MdCLE8 regulates lateral root development in apple - Tian-en Zhang; Yan Shi; Xiu-ming Li; Qiang Zhao; Chun-xiang You (Plant Cell, Tissue and Organ Culture (PCTOC), 2022)

Comparative transcriptome analysis revealed the molecular mechanism of the effect of light intensity on the accumulation of rhynchophylline and isorhynchophylline in Uncaria rhynchophylla - Xiao-Hong Wang; Xue Li; Wei Qiang; Xiao-Song Yu; Hao-Jie Zheng; Ming-Sheng Zhang (Physiology and Molecular Biology of Plants, 2022)

Oxygen Metabolism-induced Stress Response Underlies Heart–brain Interaction Governing Human Consciousness-breaking and Attention - Xiao-Juan Xue; Rui Su; Ze-Feng Li; Xiao-Ou Bu; Peng Dang; Si-Fang Yu; Zhi-Xin Wang; Dong-Mei Chen; Tong-Ao Zeng; Ming Liu; Hai-Lin Ma; De-Long Zhang (Neuroscience Bulletin, 2022)

Systematic Input–Output Mapping Reveals Structural Plasticity of VTA Dopamine Neurons-Zona Incerta Loop Underlying the Social Buffering Effects in Learned Helplessness - Hongwei Cai; Pei Zhang; Guangjian Qi; Lijun Zhang; Tongxia Li; Ming Li; Xinyuan Lv; Jie Lei; Jie Ming; Bo Tian (Molecular Neurobiology, 2022)

Bacterial diversity rather than available Cd is the main driver of exoenzyme activity and stoichiometry after soil amendments in mildly contaminated soil - Xinqi Wang; Xiuwen Wu; Beibei Zhang; Zhuoqing Li; Huihui Du; Boqing Tie; Ming Lei (Journal of Soils and Sediments, 2022)

Transgelin-2 interacts with CD44 to regulate Notch1 signaling pathway and participates in colorectal cancer proliferation and migration - Rong Ding; Guoyu Li; Yueyi Yao; Lijuan Zhang; Xuan Zhang; Jiayi Li; Tao Shen; Yi Gao; Tao Wu; Shuzhen Kong; Ming Huang; Yunfeng Li (Journal of Physiology and Biochemistry, 2022)

Analysis on shadow price and abatement potential of carbon dioxide in China’s provincial industrial sectors - Zhaoquan Xue; Hailin Mu; Nan Li; Ming Zhang (Environmental Science and Pollution Research, 2022)

Selenium Attenuates S. aureus-Induced Inflammation by Regulation TLR2 Signaling Pathway and NLRP3 Inflammasome in RAW 264.7 Macrophages - Ming-Ji Wei; Zhen-Nan Wang; Yan Yang; Shu-Jiu Zhang; He Tang; Hui Li; Chong-Liang Bi (Biological Trace Element Research, 2022)

Effect of tree form on wheat yield via changing microenvironment in almond–wheat intercropping - Wen Zhang; Hui Xie; Shou-An Han; Min Wang; Ming-Qi Pan; Xu Qiao; Long Li (Agroforestry Systems, 2022)

A feasible vibration measurement and active control method of reinforced concrete lightweight pier railway bridges for heavy-haul monorail trains - Ling-kun Chen; Li-zhong Jiang; Rui Li; Qiao Li; Ming Zhang; Nan Zhang; Jin-zhang Luo; Liang Ling; Sheng-yang Zhu (European Journal of Environmental and Civil Engineering, 2022)

Near-epicenter weather conditions several hours before strong earthquakes (Ms ≥ 6) - Tao Chen; Lei Li; Xiao-Xin Zhang; Qi-Ming Ma; Wen Li; Shuo Ti; Han Wu; Ren-Kang Li; Jing Luo; Jian-Feng Su (Natural Hazards, 2022)

Phloroglucinol derivatives as anti-tumor agents: synthesis, biological activity evaluation and molecular docking studies - Fuli Zhang; Qingfu Lai; Weihong Lai; Ming Li; Xiaobao Jin; Lianbao Ye (Medicinal Chemistry Research, 2022)

Nitrogen Addition in a Tibetan Alpine Meadow Increases Intraspecific Variability in Nitrogen Uptake, Leading to Increased Community-level Nitrogen Uptake - Li Zhang; Ming Ni; Tongbin Zhu; Xingliang Xu; Shurong Zhou; Bill Shipley (Ecosystems, 2022)

Astragalus Polysaccharide Protects Against Cadmium-Induced Autophagy Injury Through Reactive Oxygen Species (ROS) Pathway in Chicken Embryo Fibroblast - Xudong Shen; Zequn Tang; Yu Bai; Meishuo Wan; Miao Yu; Jingyi Chen; Guangxing Li; Ruili Zhang; Ming Ge (Biological Trace Element Research, 2022)

Williamsia soli sp. nov., an actinobacterium isolated from soil at a thermal power plant in Yantai, China - Ming-Jing Zhang; Xue-Han Li; Li-Yang Peng; Shuai-Ting Yun; Zhuo-Cheng Liu; Yan-Xia Zhou (Archives of Microbiology, 2022)

Alteribacter salitolerans sp. nov., isolated from a saline-alkaline soil - Shuang Wang; Lei Sun; Manik Prabhu Narsing Rao; Guo-Hong Liu; Pin-Jiao Jin; Zhou-Yan Dong; Zheng-Han Lian; Xiao-Yu Hao; Ming-Yi Zhang; Wen-Jun Li (Archives of Microbiology, 2022)

Species Composition and Assemblages of Ichthyoplankton in Sansha Bay, Fujian Province, China - Yan Jiang; Bai-an Lin; Hao-yang He; Guang-mao Ding; Li-ting Yan; Ge Zhang; Min Liu; Lian-ming Zheng (Frontiers in Marine Science, 2021)
Sansha Bay (26.40−27.00°N, 119.50−120.20°E) is a typical semi-enclosed bay, located in northern Fujian Province, China, and adjacent to the East China Sea. The ichthyoplankton species composition and assemblage structure were investigated based on monthly sampling at 25 stations in April−September 2019, covering the important spring and summer spawning seasons in the region. Sampling was conducted in the first 3−5 days of the full moon or new moon phases using a standard plankton net through horizontal and vertical tows during daytime. In total, 25,819 ichthyoplankton samples were collected, of which 25,449 samples (i.e., 24,757 eggs and 692 larvae) were from horizontal tows. For horizontal tow samples, the ichthyoplankton were classified into 58 taxa in 15 orders and 23 families with a combination of external morphology and DNA barcoding analyses, from pelagic to demersal and benthic species. The dominant order was the Gobiiformes, including 23 species (39.7% of all species). The dominant taxa, in terms of relative abundance and frequency of occurrence, consisted of commercially important fishes, such as Setipinna tenuifilis (Valenciennes, 1848) (Engraulidae), Epinephelus akaara (Temminck and Schlegel, 1842) (Serraenidae), Collichthys lucidus (Richardson, 1844), Nibea albiflora (Richardson, 1846) (Sciaenidae), Acanthopagrus schlegelii (Bleeker, 1854), and Pagrus major (Temminck and Schlegel, 1843) (Sparidae), accounting for 78.9% of the horizontal tow samples. Low-valued and small-sized fishes, such as Stolephorus commersonnii Lacepède, 1803 (Engraulidae), Solea ovata Richardson, 1846 (Soleidae), Nuchequula nuchalis (Temminck and Schlegel, 1845), and Photopectoralis bindus (Valenciennes, 1835) (Leiognathidae), were also dominant species, accounting for 11.4% of the horizontal tow samples. The ichthyoplankton assemblage was categorized into five different temporal assemblages based on the cluster and nonmetric multidimensional scaling analysis, namely, April, May, June, July, and August−September (ANOSIM, Global R = 0.656, p < 0.01) with the highest density and richness of ichthyoplankton occurred in May. The spatial distribution pattern showed that the high density (ind./m 3 ) of ichthyoplankton occurred mainly in S12–S25 in Guanjingyang and along the Dongchong Peninsula coastline into Dongwuyang, while low density occurred mainly in S01–S11 in the northwest waters of Sandu Island (ANOVA, F = 8.270, p < 0.05). Temperature, salinity, and chlorophyll a were key factors structuring the ichthyoplankton assemblages in Sansha Bay. In addition, this study revealed the changes of the ichthyoplankton composition, density, and spatial distribution in Sansha Bay over the past three decades.

Ferroptosis inhibitory constituents from the fruits of Cullen corylifolium - Aftab Yaseen; Fan Yang; Xia Zhang; Fu Li; Bin Chen; Ahmed Hassan Ibrahim Faraag; Ming-Kui Wang; Xiao-Fei Shen; Lun Wang (Natural Product Research, 2021)

The Key Regulator of Necroptosis, RIP1 Kinase, Contributes to the Formation of Astrogliosis and Glial Scar in Ischemic Stroke - Yong-Ming Zhu; Liang Lin; Chao Wei; Yi Guo; Yuan Qin; Zhong-Sheng Li; Thomas A. Kent; Claire E. McCoy; Zhan-Xiang Wang; Yong Ni; Xian-Yong Zhou; Hui-Ling Zhang (Translational Stroke Research, 2021)
Necroptosis initiation relies on the receptor-interacting protein 1 kinase (RIP1K). We recently reported that genetic and pharmacological inhibition of RIP1K produces protection against ischemic stroke-induced astrocytic injury. However, the role of RIP1K in ischemic stroke-induced formation of astrogliosis and glial scar remains unknown. Here, in a transient middle cerebral artery occlusion (tMCAO) rat model and an oxygen and glucose deprivation and reoxygenation (OGD/Re)-induced astrocytic injury model, we show that RIP1K was significantly elevated in the reactive astrocytes. Knockdown of RIP1K or delayed administration of RIP1K inhibitor Nec-1 down-regulated the glial scar markers, improved ischemic stroke-induced necrotic morphology and neurologic deficits, and reduced the volume of brain atrophy. Moreover, knockdown of RIP1K attenuated astrocytic cell death and proliferation and promoted neuronal axonal generation in a neuron and astrocyte co-culture system. Both vascular endothelial growth factor D (VEGF-D) and its receptor VEGFR-3 were elevated in the reactive astrocytes; simultaneously, VEGF-D was increased in the medium of astrocytes exposed to OGD/Re. Knockdown of RIP1K down-regulated VEGF-D gene and protein levels in the reactive astrocytes. Treatment with 400 ng/ml recombinant VEGF-D induced the formation of glial scar; conversely, the inhibitor of VEGFR-3 suppressed OGD/Re-induced glial scar formation. RIP3K and MLKL may be involved in glial scar formation. Taken together, these results suggest that RIP1K participates in the formation of astrogliosis and glial scar via impairment of normal astrocyte responses and enhancing the astrocytic VEGF-D/VEGFR-3 signaling pathways. Inhibition of RIP1K promotes the brain functional recovery partially via suppressing the formation of astrogliosis and glial scar. Graphical Abstract

Economic Evaluation of Water-Saving Irrigation Practices for Sustainable Sugarcane Production in Guangxi Province, China - Shan-Shan He; Yuan Zeng; Zhao-Xu Liang; Yan Jing; ShiYun Tang; Baoqing Zhang; Haifeng Yan; Song Li; Tinglin Xie; Fang Tan; Ming Li (Sugar Tech, 2021)

Finite Element Analysis of a Novel Anatomical Locking Guide Plate for Anterior Column and Posterior Hemi-Transverse Acetabular Fractures - Junhao Deng; Ming Li; Jiantao Li; Zhirui Li; Fanqi Meng; Yanmei Zhou; Peifu Tang; Yanpeng Zhao; Licheng Zhang (Journal of Medical and Biological Engineering, 2021)
Purpose The increasing worldwide prevalence of anterior column-posterior hemi-transverse fracture (ACPHTF) brings formidable challenges to orthopaedic surgeons. Our newly-designed locking plate had previously demonstrated promising effects in ACPHTF, but evidence of their direct comparison with conventional internal fixations remains lacking. In this study, we aimed to compare our novel plate with the traditional devices via finite element analysis. Methods The ACPHTF model was created based on a 48-year-old volunteer’s CT data, and then fixed in three different internal fixations: an anterior column locking plate with posterior column screws, double column locking plates, and our novel anatomical locking plate. These models were next loaded with a downward vertical force of 200 N, 400 N and 600 N, and the stress peaks and displacements of three different sites were recorded and analyzed. Results We first tested the rigidity and found that our newly-designed locking plate as well as its matched screws had a greater stiffness especially when they were under a higher loading force of 600 N. Then we evaluated the displacements of fracture ends after applying these fixations. Both our novel plate and DLP showed significantly smaller displacement than LPPCS at the anterior column fracture line and the pubic branch fracture line, while our novel plate was not obviously inferior to DLP in terms of the displacement. Conclusion This novel plate demonstrates a distinct superiority in the stiffness over LPPCS and DLP and comparable displacements to DLP in ACPHTF, which suggests this novel anatomical locking guide plate should be taken into consideration in ACPHTF.

Characterization of the novel hybrid cultivar E25 of Saccharina japonica in the northern farming region of China - Li Su; Ti Feng Shan; Jing Li; Su Qin Gao; Shao Jun Pang; Xiao Fei Leng; Yan Zhang; Ming Fu Zhang; Hong Tao Gao (Journal of Applied Phycology, 2021)

Expression and Characterization of a Potent Long-Acting GLP-1 Receptor Like Agonist, Exendin-4-Fc - Wen Zhang; Ming Li; Yanlu Zan; Yi Bai (International Journal of Peptide Research and Therapeutics, 2021)
Human GLP-1 (glucagon-like peptide-1) can produce a remarkable improvement in glycemic control in patients with type 2 diabetes. However, its clinical benefits are limited by its short half-life, which is less than 2 min because of its small size and rapid enzymatic inactivation by dipeptidyl peptidase IV. We engineered Exendin-4-Fc, a 66-kDa fusion protein by linking an IgG2 Fc to Exendin-4. A stably transfected Chinese hamster ovary cell line was obtained using electroporation. Exendin-4-Fc stimulated insulin secretion in INS-1 cells in a dose- and glucose-dependent manner and increased insulin mRNA expression. The plasma half-life of Exendin-4-Fc in cynomolgus monkeys was approximately 133.92 ± 25.1 h. In the KKAy mouse model of diabetes, one intraperitoneal injection of Exendin-4-Fc (1 mg/kg) reduced blood glucose levels for 5 days. A 4-week repeat-administration study identified sustained effects on blood glucose levels. Oral glucose tolerance tests conducted at the beginning and end of this 4-week period showed that Exendin-4-Fc produced a stable glucose lowering effect. In addition, KKAy mice treated with Exendin-4-Fc showed statistically significant weight loss from day 23. In conclusion, these properties of Exendin-4-Fc demonstrated that it could be a potential long-acting GLP-1 receptor agonist for the treatment of type 2 diabetes.

Study on Mechanical and Permeability Characteristics of Containing Gas Coal-Rock Under Conventional Triaxial Compression - Bang-an Zhang; Xiao-ming Li; Dong-ming Zhang (Geotechnical and Geological Engineering, 2021)

Development of a loop-mediated isothermal amplification assay for the rapid detection of six common respiratory viruses - Nianzhen Chen; Yuying Si; Gen Li; Ming Zong; Wenyan Zhang; Yangqin Ye; Lieying Fan (European Journal of Clinical Microbiology & Infectious Diseases, 2021)

Expression profiling of WRKY transcription factors in Spinach - Yaying Ma; Shuai Chen; Hongying Yu; Ruoyu Li; Zhicong Lin; Mingxing Cai; Min Tang; Xingtan Zhang; Ray Ming (Euphytica, 2021)

Astaxanthin Ameliorates Blood Pressure in Salt-Induced Prehypertensive Rats Through ROS/MAPK/NF-κB Pathways in the Hypothalamic Paraventricular Nucleus - Hong-Li Gao; Xiao-Jing Yu; Yan Zhang; Chen-Long Wang; Yi-Ming Lei; Jia-Yue Yu; Dong-Miao Zong; Kai-Li Liu; Dong-Dong Zhang; Ying Li; Hua Tian; Nian-Ping Zhang; et al. (Cardiovascular Toxicology, 2021)

Long non-coding RNA TTC28-AS1 attenuates high glucose-induced damage in HK-2 cells depending on the regulation of miR-320a/CD2AP axis - Ji Zhang; Juan Ding; Ming Yu; Fang Li; Xue Zhou; Hongxia Shuai (Genes & Genomics, 2021)

SIRT3-mediated mitochondrial unfolded protein response weakens breast cancer sensitivity to cisplatin - Hao Chen; Dong-Ming Zhang; Zhi-Ping Zhang; Ming-Zhang Li; Hai-Feng Wu (Genes & Genomics, 2021)

Evaluation of four artificial diets on demography parameters of Neoseiulus barkeri - Ya-Ying Li; Jin-Ge Yuan; Ming-Xiu Liu; Zi-Hui Zhang; Hai-Wei Zhou; Huai Liu (BioControl, 2021)

Correction to: 2021 Taxonomic update of phylum Negarnaviricota (Riboviria: Orthornavirae), including the large orders Bunyavirales and Mononegavirales - Jens H. Kuhn; Scott Adkins; Bernard R. Agwanda; Rim Al Kubrusli; Sergey V. Alkhovsky; Gaya K. Amarasinghe; Tatjana Avšič-Županc; María A. Ayllón; Justin Bahl; Anne Balkema-Buschmann; Matthew J. Ballinger; Christopher F. Basler; et al. (Archives of Virology, 2021)

2021 Taxonomic update of phylum Negarnaviricota (Riboviria: Orthornavirae), including the large orders Bunyavirales and Mononegavirales - Jens H. Kuhn; Scott Adkins; Bernard R. Agwanda; Rim Al Kubrusli; Sergey V. Alkhovsky; Gaya K. Amarasinghe; Tatjana Avšič-Županc; María A. Ayllón; Justin Bahl; Anne Balkema-Buschmann; Matthew J. Ballinger; Christopher F. Basler; et al. (Archives of Virology, 2021)

Optimization of Ultrasound-Assisted Extraction of Peony Seed Oil with Response Surface Methodology and Analysis of Fatty Acid - Min Li; Guihong Zhao; Jian Liu; Xinpai Liang; Ming Zhang; Guangcan Zhou; Xin Tang; Yilei Wang (Agricultural Research, 2021)

Optimization of immunization procedure for SWCNTs‐based subunit vaccine with mannose modification against spring viraemia of carp virus in common carp - Yu‐Ming Gong; Chen Zhang; Yang Li; Guo Chen; Gao‐Xue Wang; Bin Zhu (Journal of Fish Diseases, 2021)
Immersion vaccination of single‐walled carbon nanotubes loaded with mannose‐modified glycoprotein (SWCNTs‐MG) vaccine has been proved to be effective in preventing spring viraemia of carp virus (SVCV). Immunization procedure has immense consequence on the immune effect of the immersion vaccine. However, immunization procedure optimization for SWCNTs‐MG vaccine against SVCV has not been reported. In this study, accordingly, a full‐factor experiment was designed to optimize the immunization procedure of SWCNTs‐MG vaccine by three aspects of vaccine dose (30 mg/L, 40 mg/L and 50 mg/L), immunization density (8 fish L −1 , 24 fish L −1 and 48 fish L −1 ) and immunization time (6, 12 and 24 hr). Furthermore, we used the immunization group (A1B2C1, 30 mg/L, 24 fish L −1 and 6 hr) in the previous study as a positive control (PC) to evaluate the immunization effect optimized conditions from the expression of immune‐related genes and relative percentage survival (RPS). At 28 days post‐vaccination (DPV), common carps were intraperitoneal injected SVCV challenged test indicated that the A1B2C2 group (30 mg/L, 24 fish L −1 , 12 hr) displayed superiority of protective efficacy compare with other groups and the RPS with 77.9%, which was 15.6% higher than the PC group of RPS with 62.3%. Moreover, the expression of immune‐related genes such as IL‐10 , CD4 and MHC‐II was also significantly higher than PC group. The specific experimental flow chart is shown in Figure 1 . Conclusively, these results demonstrated that vaccine dose, immunization density and immunization time are 30 mg/L, 24 fish L −1 and 12 hr, which is the more appropriate immunization programme with juvenile carp for SWCNTs‐MG vaccine. This study provides a profitable reference for improving the immune efficiency of aquatic immersion vaccine. The experiment process and timeline chart of the present research image

Identification and antimicrobial properties of a new alkaloid produced by marine-derived Verrucosispora sp. FIM06-0036 - Ming-Hong Chen; Yun-Yang Lian; Dong-Sheng Fang; Li Chen; Jia Jia; Wen-Long Zhang; Ru Lin; Yang Xie; Hong-Kai Bi; Hong Jiang (Natural Product Research, 2021)

Triculata A, a novel compound from Tricyrtis maculata (D. Don) J. F. Macbr. with biological properties - Li Ren; Yun-Ze Wang; Wei Zhang; Rui Zhou; Ming Zhao; Zhi-Shu Tang; Jing Sun; Dong-Bo Zhang (Natural Product Research, 2021)

Method for Analyzing Copula-Based Water Shortage Risk in Multisource Water Supply Cities - Chen An; Ming Dou; Jianling Zhang; Guiqiu Li (Water Resources Management, 2021)

FHA domain of AGGF1 is essential for its nucleocytoplasmic transport and angiogenesis - Cui-Fang Zhang; Han-Ming Wang; Andong Wu; Yang Li; Xiao-Li Tian (Science China Life Sciences, 2021)

Dopaminergic Projection from Ventral Tegmental Area to Substantia Nigra Pars Reticulata Mediates Chronic Social Defeat Stress–Induced Hypolocomotion - Feng He; Pei Zhang; Qian Zhang; Guangjian Qi; Hongwei Cai; Tongxia Li; Ming Li; Jiazhen Lu; Jiaen Lin; Jie Ming; Bo Tian (Molecular Neurobiology, 2021)

Geo-structures and deformation-failure characteristics of rockslide areas near the Baige landslide scar in the Jinsha River tectonic suture zone - Shi-lin Zhang; Yue-ping Yin; Xie-wen Hu; Wen-pei Wang; Zong-liang Li; Xin-ming Wu; Gang Luo; Sai-nan Zhu (Landslides, 2021)

Eutrophication model driven by light and nutrients condition change in sluice-controlled river reaches - Ming Dou; Li Liang; Yuping Han; Ruipeng Jia; Yan Zhang (Environmental Science and Pollution Research, 2021)

Exposure to 2,4-dichlorophenol, 2,4,6-trichlorophenol, pentachlorophenol and risk of thyroid cancer: a case-control study in China - Wan-Jun Yang; Hua-Bing Wu; Chi Zhang; Qi Zhong; Ming-Jun Hu; Jia-Liu He; Guo-Ao Li; Zhen-Yu Zhu; Jin-Liang Zhu; Huan-Huan Zhao; Han-Shuang Zhang; Fen Huang (Environmental Science and Pollution Research, 2021)

Effect of increasing rainfall on the thermal—moisture dynamics of permafrost active layer in the central Qinghai—Tibet Plateau - Zhi-xiong Zhou; Feng-xi Zhou; Ming-li Zhang; Bing-bing Lei; Zhao Ma (Journal of Mountain Science, 2021)

Effects of organic acids on the chemotaxis profiles and biocontrol traits of antagonistic bacterial endophytes against root-rot disease in Panax notoginseng - Li Ma; Wu-Qin Wang; Rui Shi; Xue-Mei Zhang; Xin Li; Yu-Sen Yang; Ming He Mo (Antonie van Leeuwenhoek, 2021)

Seasonal life strategy of Prorocentrum minimum in Chesapeake Bay, USA : Validation of the role of physical transport using a coupled physical–biogeochemical–harmful algal bloom model - Ming Li; Fan Zhang; Patricia M. Glibert (Limnology and Oceanography, 2021)
Over 40 years ago, it was suggested that Prorocentrum minimum in Chesapeake Bay has a seasonal life strategy that depends on the physical transport by estuarine circulation, bringing cells from lower bay to the mid‐bay in spring when they bloom. In this study, a validated hydrodynamic‐biogeochemical model is used to simulate the annual cycles of P. minimum in Chesapeake Bay and track its life history over multiple years. The model reproduces the observed seasonal progression of P. minimum without a seed population. Four life stages of P. minimum are faithfully produced in the model: (1) in winter, overwintering populations from the previous bloom are distributed throughout the water column in the lower bay; (2) in late winter/early spring, cells are transported upstream by the landward bottom flows; (3) in May, P. minimum develops a bloom in the mid‐bay; (4) in late summer/fall, decaying P. minimum populations are transported downstream by the seaward surface flows. Particle tracking shows that it takes about 3–4 months for the overwintering cells to travel from the lower bay to the mid‐bay, but about 6 months for the decaying cells to travel from the mid‐bay to the lower bay, as the estuarine circulation is far stronger during the high runoff months of January–May than during the low runoff months of June–December. With the peak growth rate around 20°C, May provides an optimal window of growth opportunity for P. minimum as phytoplankton assemblage transitions from winter–spring diatoms to summer dinoflagellates in a seasonal succession.

Highly integrated adaptive mechanisms in Spiribacter halalkaliphilus , a bacterium abundant in Chinese soda‐saline lakes - Qiong Xue; Dahe Zhao; Shengjie Zhang; Heng Zhou; Zhenqiang Zuo; Jian Zhou; Ming Li; Hua Xiang (Environmental Microbiology, 2021)
Summary Soda‐saline lakes are polyextreme environments inhabited by many haloalkaliphiles, including one of the most abundant Spiribacter species. However, its mechanisms of adaptation are not ecophysiologically characterized. Based on a large‐scale cultivation strategy, we obtained a representative isolate of this Spiribacter species whose relative abundance was the highest (up to 15.63%) in a wide range of salinities in the soda‐saline lakes in Inner Mongolia, China. This species is a chemoorganoheterotrophic haloalkaliphile. It has a small and streamlined genome and utilizes a wide variety of compatible solutes to resist osmotic pressure and multiple monovalent cation/proton antiporters for pH homeostasis. In addition to growth enhancement by light under microaerobic conditions, cell growth, organic substrate consumption and polyhydroxybutyrate biosynthesis were also improved by inorganic sulfide. Both quantitative RT‐PCR and enzymatic assays verified that sulfide:quinone oxidoreductase was upregulated during this process. Metatranscriptomic analysis indicated that all genes related to environmental adaptation were transcribed in natural environments. Overall, this study has identified a novel abundant haloalkaliphile with multiple and highly integrated adaptive strategies and found that inorganic sulfide was able to improve the adaptation of a heterotroph to polyextreme environments.

Tissue distribution of SARS-CoV-2 in non-human primates after combined intratracheal and intranasal inoculation - Tian-Zhang Song; Jian-Bao Han; Xiang Yang; Ming-Hua Li; Yong-Tang Zheng (Science China Life Sciences, 2021)

Influence of algal blooms on the efficacy of La/Al-based phoslock in the control of phosphorus release from sediment in shallow lakes: a microcosm study - Tianlun Han; Ming Kong; Chenjie Tang; Xueting Xu; Yanzhong Zhu; Yuexiang Gao; Tao Zhang; Yimin Zhang; Weixin Li (Journal of Soils and Sediments, 2021)

Apportioning above- and below-ground effects of moss biocrusts on soil detachment by overland flow in a subtropical climate - Guan-hua Zhang; Liang Yi; Wen-feng Ding; Xu Lei; Yi-ran Wang; Bao-yang Sun; Jian-ming Li (Journal of Mountain Science, 2021)

Dynamic prediction of landslide displacement using singular spectrum analysis and stack long short-term memory network - Li-min Li; Ming-yue Zhang; Zong-zhou Wen (Journal of Mountain Science, 2021)

Supply‐controlled calcium carbonate dissolution decouples the seasonal dissolved oxygen and pH minima in Chesapeake Bay - Jianzhong Su; Wei‐Jun Cai; Jeremy M. Testa; Jean R. Brodeur; Baoshan Chen; K. Michael Scaboo; Ming Li; Chunqi Shen; Margaret Dolan; Yuan‐Yuan Xu; Yafeng Zhang; Najid Hussain (Limnology and Oceanography, 2021)
Acidification can present a stress on organisms and habitats in estuaries in addition to hypoxia. Although oxygen and pH decreases are generally coupled due to aerobic respiration, pH dynamics may be more complex given the multiple modes of buffering in the carbonate system. We studied the seasonal cycle of dissolved oxygen (DO), pH, dissolved inorganic carbon, total alkalinity, and calcium ion (Ca 2+ ) along the main channel of Chesapeake Bay from May to October in 2016. Contrary to the expected co‐occurrence of seasonal DO and pH declines in subsurface water, we found that the pH decline ended in June while the DO decline continued until August in mid‐Chesapeake Bay. We discovered that aerobic respiration was strong from May to August, but carbonate dissolution was minor in May and June and became substantial in August, which buffered further pH declines and caused the seasonal DO and pH minima mismatch. The rate of calcium carbonate (CaCO 3 ) dissolution was not primarily controlled by the saturation state in bottom water, but was instead likely controlled by the supply of CaCO 3 particles. The seasonal variability of Ca 2+ addition in the mid‐bay was connected to Ca 2+ removal in the upper bay, and the timing of high carbonate dissolution coincided with peak seasonal biomass of upper Bay submerged aquatic vegetation. This study suggests a mechanism for a novel decoupling of DO and pH in estuarine waters associated with CaCO 3 , but future studies are needed to fully investigate the seasonality of physical transport and cycling of CaCO 3 .

Cysestermerol A, a rare stilbene sestermer with significant hypoglycemic activities from Cynodon dactylon - Feng Wang; Li Zhang; Bi-Jun Li; Qiu-Ming Liang; A-Li Chen; Zhen-Feng Fang; Shu-Mei Wang (Natural Product Research, 2021)

Identification of a recessive gene YrZ15-1370 conferring adult plant resistance to stripe rust in wheat-Triticum boeoticum introgression line - Minghu Zhang; Xin Liu; Ting Peng; Dinghao Wang; Dongyu Liang; Hongyu Li; Ming Hao; Shunzong Ning; Zhongwei Yuan; Bo Jiang; Xuejiao Chen; Xue Chen; et al. (Theoretical and Applied Genetics, 2021)

Genetic control and phenotypic characterization of panicle architecture and grain yield-related traits in foxtail millet (Setaria italica) - Hui Zhi; Qiang He; Sha Tang; Junjun Yang; Wei Zhang; Huifang Liu; Yanchao Jia; Guanqing Jia; Aiying Zhang; Yuhui Li; Erhu Guo; Ming Gao; et al. (Theoretical and Applied Genetics, 2021)

Improvement in the risk assessment of oral leukoplakia through morphology-related copy number analysis - Xiaotian Li; Lu Liu; Jianyun Zhang; Ming Ma; Lisha Sun; Xuefen Li; Heyu Zhang; Jianbin Wang; Yanyi Huang; Tiejun Li (Science China Life Sciences, 2021)

Association between large artery stenosis, cerebral small vessel disease and risk of ischemic stroke - Fei Han; Ding-Ding Zhang; Fei-Fei Zhai; Jun Xue; Jiang-Tao Zhang; Shuang Yan; Li-Xin Zhou; Jun Ni; Ming Yao; Meng Yang; Ming-Li Li; Zheng-Yu Jin; et al. (Science China Life Sciences, 2021)

Grafting improves tomato yield under low nitrogen conditions by enhancing nitrogen metabolism in plants - Zhi Huan Zhang; Ming Ming Li; Bi Li Cao; Zi Jing Chen; Kun Xu (Protoplasma, 2021)

Study on indirect economic impacts and their causes of the 2008 Wenchuan earthquake - Yan Song; Zhenran Li; Xiao Zhang; Ming Zhang (Natural Hazards, 2021)

Chronic AdipoRon Treatment Mimics the Effects of Physical Exercise on Restoring Hippocampal Neuroplasticity in Diabetic Mice - Thomas H Lee; Ahadullah; Brian R Christie; Kangguang Lin; Parco Ming-fai Siu; Li Zhang; Ti-fei Yuan; Pragya Komal; Aimin Xu; Kwok-fai So; Suk-yu Yau (Molecular Neurobiology, 2021)
Administration of exercise mimetic drugs could be a novel therapeutic approach to combat comorbid neurodegeneration and metabolic syndromes. Adiponectin is an adipocyte-secreted hormone. In addition to its antidiabetic effect, adiponectin mediates the antidepressant effect of physical exercise associated with adult hippocampal neurogenesis. The antidiabetic effect of the adiponectin receptor agonist AdipoRon has been demonstrated, but its potential pro-cognitive and neurotrophic effects in the hippocampus under diabetic condition are still unclear. This study reported that chronic AdipoRon treatment for 2 weeks improved hippocampal-dependent spatial recognition memory in streptozotocin-induced diabetic mice. Besides, AdipoRon treatment increased progenitor cell proliferation and neuronal differentiation in the hippocampal dentate gyrus (DG) of diabetic mice. Furthermore, AdipoRon treatment significantly increased dendritic complexity, spine density, and N -methyl-D-aspartate receptor-dependent long-term potentiation (LTP) in the dentate region, and increased BDNF levels in the DG of diabetic mice. AdipoRon treatment activated AMPK/PGC-1α signalling in the DG, whereas increases in cell proliferation and LTP were not observed when PGC-1α signalling was pharmacologically inhibited. In sum, chronic AdipoRon treatment partially mimics the benefits of physical exercise for learning and memory and hippocampal neuroplasticity in the diabetic brain. The results suggested that AdipoRon could be a potential physical exercise mimetic to improve hippocampal plasticity and hence rescue learning and memory impairment typically associated with diabetes.

Nutrient Uptake and Distribution in Mycorrhizal Cuttings of Populus × canadensis ‘Neva’ Under Drought Stress - Li Li; Haoqiang Zhang; Ming Tang; Hui Chen (Journal of Soil Science and Plant Nutrition, 2021)

Apigenin Improves Hypertension and Cardiac Hypertrophy Through Modulating NADPH Oxidase-Dependent ROS Generation and Cytokines in Hypothalamic Paraventricular Nucleus - Hong-Li Gao; Xiao-Jing Yu; Han-Bo Hu; Qian-Wen Yang; Kai-Li Liu; Yan-Mei Chen; Yan Zhang; Dong-Dong Zhang; Hua Tian; Guo-Qing Zhu; Jie Qi; Yu-Ming Kang (Cardiovascular Toxicology, 2021)

CRWS-mountain Project: Coordinate remediation techniques and devices for water-soil pollution in mountain areas in China - Ling Song; Lei Li; Chao-jie Zhang; Li Huang; Jin-song Guo; Bo Zhu; Ming-hua Zhou (Journal of Mountain Science, 2021)

Tracing Nutrients and Organic Matter Changes in Eutrophic Wenchang (China) and Oligotrophic Krka (Croatia) Estuaries: A Comparative Study - You-You Hao; Zhuo-Yi Zhu; Fu-Tao Fang; Tihana Novak; Milan Čanković; Enis Hrustić; Zrinka Ljubešić; Ming Li; Jin-Zhou Du; Rui-Feng Zhang; Blaženka Gašparović (Frontiers in Marine Science, 2021)
Estuaries modify the concentration and composition of riverine nutrients and organic matter (OM), which eventually determine the riverine flux effect to coasts. Nutrients, organic carbon (OC), pigments, and amino acids (AAs) from the samples collected in the eutrophic Wenchang River Estuary (WRE) in China and the oligotrophic Krka River Estuary (KRE) in Croatia were analyzed in order to have a better understanding of how estuaries regulate terrestrial materials. We found a clear increase of dissolved inorganic nitrogen (DIN) concentration and its subsequent decrease due to the removal of DIN (over 100 μM) in the WRE, whereas DIN showed minor variation lengthwise in the KRE, i.e., with the salinity changes, ranging between 1.0 and 5.8 μM. The elevated algae-derived OC, dissolved organic nitrogen, and particulate AAs nitrogen suggest that the OM assimilation may explain approximately one-third of the DIN removal in the WRE, whereas in the oligotrophic KRE, such inorganic to organic transformation is not likely to be significant. Due to the prominent estuarine nitrogen removal/assimilation process, DIN/dissolved inorganic phosphorus (DIP) ratio was as high as 425 in the upper WRE under strong riverine influence, but it declined to as low as 5.4 at the mouth of WRE, that is even lower than DIN/DIP ratio at the mouth of oligotrophic KRE (12). When compared with other rivers worldwide, the Wenchang River showed high nutrients and organic carbon yields. Given the contrasting estuarine process (e.g., DIN removal) between the KRE and the WRE, apparent high nutrient yield from eutrophic rivers should be viewed with caution in ocean studies as the final impact to coastal zone could be similar to the oligotrophic rivers like the KRE.

Anti-Inflammatory and anti-proliferative oleanane-type triterpene glycosides from the vine of Momordica cochinchinensis - Hung-Tse Huang; Yu-Chi Lin; Li-Jie Zhang; Chia-Ching Liaw; Hsin-Yen Chen; Ming-Tung Hsueh; Yao-Haur Kuo (Natural Product Research, 2021)

The downregulation of PpPG21 and PpPG22 influences peach fruit texture and softening - Ming Qian; Ze Xu; Zehua Zhang; Qin Li; Xiangyan Yan; Hangkong Liu; Mingyu Han; Furui Li; Jicheng Zheng; Dong Zhang; Caiping Zhao (Planta, 2021)

Pinocembrin-7-Methylether Protects SH-SY5Y Cells Against 6-Hydroxydopamine-Induced Neurotoxicity via Modulating Nrf2 Induction Through AKT and ERK Pathways - Zhi-Cong Zou; Ji-Jun Fu; Yuan-Ye Dang; Qian Zhang; Xiu-Fen Wang; Han-Bin Chen; Xue-Jing Jia; Simon Ming-Yuen Lee; Chu-Wen Li (Neurotoxicity Research, 2021)

Application of Plant Print Identification Technology in Salt-resistant Soybean Breeding - Yan Li; Xia Li; Zi-qi Chen; Ying Ma; Guang-yu Yang; Ying Zhang; Ming-chun Sun; Li-hong Zhang; Jin-meng Chu; Jing-mei Lu; Jun Zhu; Ji-hong You (Journal of Plant Growth Regulation, 2021)

Convergence analysis of regional marginal abatement cost of carbon dioxide in China based on spatial panel data models - Zhaoquan Xue; Nan Li; Hailin Mu; Ming Zhang; Jingru Pang (Environmental Science and Pollution Research, 2021)

Phylogenomic Analyses of a Clade Within the Family Flavobacteriaceae Suggest Taxonomic Reassignments of Species of the Genera Algibacter, Hyunsoonleella, Jejuia, and Flavivirga, and the Proposal of Pseudalgibacter gen. nov. and Pseudalgibacter alginicilyticus comb. nov. - Miao Li; Ling-Zhi Hou; Xing-Hao Xu; Xiao-Xiao Wang; Ming-Can Zheng; Yan-Jiao Zhang; Ang Liu (Current Microbiology, 2021)

White matter characteristics between amygdala and prefrontal cortex underlie depressive tendency in end stage renal disease patients before the dialysis initiation - Junya Mu; Liang Ma; Dun Ding; Xueying Ma; Peng Li; Ruixiao Li; Ming Zhang; Jixin Liu (Brain Imaging and Behavior, 2021)

Flexible reconfiguration of functional brain networks as a potential neural mechanism of creativity - Junchao Li; Natasza Orlov; Zengjian Wang; Bingqing Jiao; Yibo Wang; Huawei Xu; Hui Yang; Yingying Huang; Yan Sun; Peng Zhang; Rengui Yu; Ming Liu; et al. (Brain Imaging and Behavior, 2021)

The developmental regulator PatD modulates assembly of the cell‐division protein FtsZ in the cyanobacterium Anabaena sp. PCC 7120 - Li Wang; Tian‐Cai Niu; Ana Valladares; Gui‐Ming Lin; Ju‐Yuan Zhang; Antonia Herrero; Wen‐Li Chen; Cheng‐Cai Zhang (Environmental Microbiology, 2021)
Summary FtsZ is a tubulin‐like GTPase that polymerizes to initiate the process of cell division in bacteria. Heterocysts are terminally differentiated cells of filamentous cyanobacteria that have lost the capacity for cell division and in which the ftsZ gene is downregulated. However, mechanisms of FtsZ regulation during heterocyst differentiation have been scarcely investigated. The patD gene is NtcA dependent and involved in the optimization of heterocyst frequency in Anabaena sp. PCC 7120. Here, we report that the inactivation of patD caused the formation of multiple FtsZ‐rings in vegetative cells, cell enlargement, and the retention of peptidoglycan synthesis activity in heterocysts, whereas its ectopic expression resulted in aberrant FtsZ polymerization and cell division. PatD interacted with FtsZ, increased FtsZ precipitation in sedimentation assays, and promoted the formation of thick straight FtsZ bundles that differ from the toroidal aggregates formed by FtsZ alone. These results suggest that in the differentiating heterocysts, PatD interferes with the assembly of FtsZ. We propose that in Anabaena FtsZ is a bifunctional protein involved in both vegetative cell division and regulation of heterocyst differentiation. In the differentiating cells PatD‐FtsZ interactions appear to set an FtsZ activity that is insufficient for cell division but optimal to foster differentiation.

Neuroprotective triterpene saponins from the leaves of Panax notoginseng - Ji-Wu Huang; Yi-Qian Du; Chuang-Jun Li; Jing-Zhi Yang; Jie Ma; Ying-Da Zang; Nai-Hong Chen; Dong-Ming Zhang (Natural Product Research, 2021)

HDAC3 Downregulation Improves Cerebral Ischemic Injury via Regulation of the SDC1-Dependent JAK1/STAT3 Signaling Pathway Through miR-19a Upregulation - Hua Fang; Hua-Feng Li; Ming-Hai He; Miao Yang; Jian-Ping Zhang (Molecular Neurobiology, 2021)

Transforming growth factor β as a possible independent factor in chronic hepatitis B - Ming-hui Li; Yao Lu; Fang-fang Sun; Qi-qi Chen; Lu Zhang; Hui-hui Lu; Zhan Zeng; Wei Yi; Yao Xie (Archives of Virology, 2021)

Glaciibacter flavus sp. nov., isolated from a lichen sample - De-Feng An; Long-Qian Jiang; Kun Zhang; Gui-Ding Li; Xin-Yu Wang; Ming-Guo Jiang; Lei Lang; Li-Song Wang; Johannes F. Imhoff; Cheng-Lin Jiang; Yi Jiang (Archives of Microbiology, 2021)

Evolving a Bayesian network model with information flow for time series interpolation of multiple ocean variables - Ming Li; Ren Zhang; Kefeng Liu (Acta Oceanologica Sinica, 2021)

Neuroprotective carbazole alkaloids from the stems and leaves of Clausena lenis - Gui Yan; Yu-Jie Li; Ying-Ying Zhao; Jia-Ming Guo; Wen-Hao Zhang; Ming-Ming Zhang; Yan-Hui Fu; Yan-Ping Liu (Natural Product Research, 2021)

A New Marine Disaster Assessment Model Combining Bayesian Network with Information Diffusion - Ming Li; Ren Zhang; Kefeng Liu (Journal of Marine Science and Engineering, 2021)
There are two challenges in the comprehensive marine hazard assessment. The influencing mechanism of marine disaster is uncertain and disaster data are sparse. Aiming at the uncertain knowledge and small sample in assessment modeling, we combine the information diffusion algorithm and Bayesian network to propose a novel assessment model. The information diffusion algorithm is adopted to expand associated samples between disaster losses and environmental conditions. Then the expanded data sets are used to build the BN-based assessment model through structural learning, parameter learning and probabilistic reasoning. The proposed model is applied to the hazard assessment of marine disasters in Shanghai. Experimental comparison results show that it is capable of dealing with uncertainty effectively and achieving more accuracy risk assessment under the small sample condition.

Isolation and characterization of a new cytotoxic polyketide–amino acid hybrid from Thermothelomyces thermophilus ATCC 42464 - Yang-Le Gao; Ming-Liang Zhang; Xue Wang; Huai-Dong Zhang; Jian-Zhong Huang; Li Li (Natural Product Research, 2021)

Genome-wide identification of auxin response factor (ARF) family in kiwifruit (Actinidia chinensis) and analysis of their inducible involvements in abiotic stresses - Liyan Su; Ming Xu; Jiudong Zhang; Yihang Wang; Yushan Lei; Qiang Li (Physiology and Molecular Biology of Plants, 2021)

Different posterior hippocampus and default mode network modulation in young APOE ε4 carriers: a functional connectome-informed phenotype longitudinal study - Li Juan Zheng; Li Lin; U. Joseph Schoepf; Akos Varga-Szemes; Rock H. Savage; Han Zhang; Yun Fei Wang; Xin Yuan Zhang; Song Luo; Ya Liu; Gui Fen Yang; Guang Ming Lu; et al. (Molecular Neurobiology, 2021)

OsGSTU6 Contributes to Cadmium Stress Tolerance in Rice by Involving in Intracellular ROS Homeostasis - Xiu-Qing Jing; Meng-Ru Zhou; Xiu-Min Nie; Lu Zhang; Peng-Tao Shi; Abdullah Shalmani; Hai Miao; Wen-Qiang Li; Wen-Ting Liu; Kun-Ming Chen (Journal of Plant Growth Regulation, 2021)

Supercooling capacity and cold tolerance of the South American tomato pinworm, Tuta absoluta, a newly invaded pest in China - Xiao-wei Li; Dong Li; Zhi-jun Zhang; Jun Huang; Jin-ming Zhang; Muhammad Hafeez; Li-kun Wang; Wen-chao Guo; Yao-bin Lu (Journal of Pest Science, 2021)
Tuta absoluta is a devastating invasive pest worldwide, causing severe damage to the global tomato industry. It has been recorded recently in the northwestern border areas of China, posing a significant threat to tomato production. It was presumed that the region's winter-related low temperatures would avert the alien species from successfully overwintering. In this study, the supercooling capacity and low-temperature tolerance of this pest were examined under laboratory conditions and its overwintering potential in Xinjiang was estimated. The results showed that the lowest supercooling point was recorded in the adult stage (− 19.47 °C), while the highest (− 18.11 °C) was recorded in the pupal stage. The supercooling points of pupae and adults were not influenced by gender. The Ltemp 50 and Ltemp 90 of female and male adults were the lowest when exposed to cold for 2 h. However, when the duration of exposure extended from 4 to 10 h, the Ltemp 50 and Ltemp 90 of female and male pupae were the lowest. Comparison of the lowest Ltemp 50 and Ltemp 90 with temperatures in January indicated that T. absoluta might not be able to overwinter in most of the northern and central regions of Xinjiang. However, in the southern regions, the extremely low temperature was higher than the Ltemp 90 , suggesting that T. absoluta has a higher overwintering potential in these regions. These results form a basis for predicting the dispersal potential and possible geographic range of this pest in Xinjiang. In addition, our findings provide guidance for the control of this pest by reducing overwintering shelters.

A transcription factor TaTCP20 regulates the expression of Ppd-D1b in common wheat - Fan Wei; Tianqi Song; Jianfei Zhou; Jie Cheng; Ruibo Li; Ming Yu; Yunrui Zhang; Yang Yu; Bo Zhang; Xiaoke Zhang (Plant Biotechnology Reports, 2021)

Risk Assessment of Marine Environments Along the South China Sea and North Indian Ocean on the Basis of a Weighted Bayesian Network - Ming Li; Ren Zhang; Kefeng Liu (Journal of Ocean University of China, 2021)

Sphingopyxis microcysteis sp. nov., a novel bioactive exopolysaccharides-bearing Sphingomonadaceae isolated from the Microcystis phycosphere - Xiao-ling Zhang; Gui-xian Li; Ya-ming Ge; Nurhezreen Md Iqbal; Xi Yang; Zhen-dong Cui; Qiao Yang (Antonie van Leeuwenhoek, 2021)

Pigmentibacter ruber gen. nov., sp. nov., a novel bacterium of the family Silvanigrellaceae isolated from human blood - Na Peng; Wen Xu; Hai-Min Luo; Peng-Wen Ouyang; Bin Jiang; Zhi-Hua Zhang; You-De Cao; Li-Ming Tan; Ping-Hua Qu; Liang-Yi Xie (Antonie van Leeuwenhoek, 2021)

Physiological determinants of biogeography: The importance of metabolic depression to heat tolerance - Ming‐ling Liao; Gao‐yang Li; Jie Wang; David J. Marshall; Tin Yan Hui; Shu‐yang Ma; Yi‐min Zhang; Brian Helmuth; Yun‐wei Dong (Global Change Biology, 2021)
A quantitative understanding of physiological thermal responses is vital for forecasting species distributional shifts in response to climate change. Many studies have focused on metabolic rate as a global metric for analyzing the sublethal effects of changing environments on physiology. Thermal performance curves (TPCs) have been suggested as a viable analytical framework, but standard TPCs may not fully capture physiological responses, due in part to failure to consider the process of metabolic depression. We derived a model based on the nonlinear regression of biological temperature‐dependent rate processes and built a heart rate data set for 26 species of intertidal molluscs distributed from 33°S to ~40°N. We then calculated physiological thermal performance limits with continuous heating using , the temperature at which heart rate is decreased to 50% of the maximal rate, as a more realistic measure of upper thermal limits. Results indicate that heat‐induced metabolic depression of cardiac performance is a common adaptive response that allows tolerance of harsh environments. Furthermore, our model accounted for the high inter‐individual variability in the shape of cardiac TPCs. We then used these TPCs to calculate physiological thermal safety margins (pTSM), the difference between the maximal operative temperature (95th percentile of field temperatures) and of each individual. Using pTSMs, we developed a physiological species distribution model (pSDM) to forecast future geographic distributions. pSDM results indicate that climate‐induced species range shifts are potentially less severe than predicted by a simple correlative SDM. Species with metabolic depression below the optimum temperature will be more thermal resistant at their warm trailing edges. High intraspecific variability further suggests that models based on species‐level vulnerability to environmental change may be problematic. This multi‐scale, mechanistic understanding that incorporates metabolic depression and inter‐individual variability in thermal response enables better predictions about the relationship between thermal stress and species distributions.

Antibacterial and anti-biofilm effects of fatty acids extract of dried Lucilia sericata larvae against Staphylococcus aureus and Streptococcus pneumoniae in vitro - Jing Liu; Jun Jiang; Junwei Zong; Bin Li; Taowen Pan; Yunpeng Diao; Zhen Zhang; Xueyang Zhang; Ming Lu; Shouyu Wang (Natural Product Research, 2021)

Machine Learning Incorporated With Causal Analysis for Short-Term Prediction of Sea Ice - Ming Li; Ren Zhang; Kefeng Liu (Frontiers in Marine Science, 2021)
Accurate and fast prediction of sea ice conditions is the foundation of safety guarantee for Arctic navigation. Aiming at the imperious demand of short-term prediction for sea ice, we develop a new data-driven prediction technique for the sea ice concentration (SIC) combined with causal analysis. Through the causal analysis based on kernel Granger causality (KGC) test, key environmental factors affecting SIC are selected. Then multiple popular machine learning (ML) algorithms, namely self-adaptive differential extreme learning machine (SaD-ELM), classification and regression tree (CART), random forest (RF) and support vector regression (SVR), are employed to predict daily SIC, respectively. The experimental results in the Barents-Kara (B-K) sea show: (1) compared with correlation analysis, the input variables of ML models screened out by causal analysis achieve better prediction; (2) when lead time is short (<3 d), the four ML algorithms are all suitable for short-term prediction of daily SIC, while RF and SaD-ELM have better prediction performance with long lead time (>3 d); (3) RF has the best prediction accuracy and generalization ability but hugely time consuming, while SaD-ELM achieves more favorable performance when taking computational complexity into consideration. In summary, ML is applicable to short-term prediction of daily SIC, which develops a new way of sea ice prediction and provides technical support for Arctic navigation.

Study on Microwave Heating Order and Electromagnetic Characteristics of Copper and Gold Ores - Feng Lin; Xia-Ting Feng; Gao-Ming Lu; Xiang-Xin Su; Shi-Ping Li; Jiu-yu Zhang (Rock Mechanics and Rock Engineering, 2021)

miR-34c inhibits PDGF-BB-induced HAVSMCs phenotypic transformation and proliferation via PDGFR-β/SIRT1 pathway - Wei-feng Wan; Xin Zhang; Chang-ren Huang; Li-gang Chen; Xiao-bo Yang; Kun-yang Bao; Tang-ming Peng (Molecular Biology Reports, 2021)
The purpose of this study was to explore the effect of miR-34c on PDGF-BB-induced HAVSMCs phenotypic transformation and proliferation via PDGFR-β/SIRT1 pathway, so as to find a new method for early diagnosis and treatment of cardiovascular disease. HA-VSMCs were treated with platelet-derived growth factor-BB (PDGF-BB) at 0 h, 12 h, 24 h, 48 h or 36 h to explore the optimal time for phenotypic transformation of VSMCs. And then, PDGF-BB-induced HA-VSMCs were transfected with miR-34c mimics/mimics NC and pcDNA3.1-PDGFR-β/pcDNA3.1-NC to observe cell biological behaviour. CCK8 was used to detect cell proliferation activity. Transwell chamber assay was used to detect cell invasion. Early apoptosis was analyzed by flow cytometry. The expression of α-SMA and Smemb was detected by immunofluorescence staining. The expressions of PDGFR-β, IRF9, Acetyl-NF-κB/p65, Acetyl-p53 and CyclinD1 were analyzed by Western blot analysis. The expression of miR-34a, miR-34b and miR-34c was detected by RT-PCR, and the targeting relationship between miR-34c and PDGFR-β was detected by luciferase reporting assay. The results indicated the proliferation and migration of PDGF-BB-induced HA-VSMCs significantly increased, and apoptosis significantly decreased. Besides, α-SMA decreased significantly, while Smemb increased significantly. Furthermore, expressions of PDGFR-β, IRF9, Acetyl-NF-κB/p65, Acetyl-p53 and CyclinD1 increased significantly, and SIRT1 decreased significantly. Experimental results showed that, miR-34c mimics significantly inhibited cell proliferation and migration, and promoted cell apoptosis, and miR-34c inhibitor had the opposite effects. MiR-34c mimics significantly increased α-SMA expression and decreased Smemb expression, while the opposite effects were reflected after transfection with miR-34c inhibitor. Moreover, miR-34c mimics significantly decreased the expressions of PDGFR-β, IRF9, Acetyl-NF-κB/p65, Acetyl-p53 and CyclinD1, and significantly increased the expression of SIRT1, while miR-34c inhibitor had the opposite effects. Luciferase assay confirmed that PDGFR-β was a potential target of miR-34c. Subsequently, PDGF-BB-induced HA-VSMCs were co-transfected with miR-34c mimics and pcDNA3.1-PDGFR-β. The results indicated that PDGFR-β reversed the biological function of miR-34c mimic. The results revealed the potential application value of miR-34c as a marker molecule of phenotypic transformation, providing a potential target for improving phenotypic transformation.

Design, synthesis and evaluation of dihydrotriazine derivatives-bearing 5-aryloxypyrazole moieties as antibacterial agents - Tian-Yi Zhang; Chun-Shi Li; Ming-Yue Cui; Xue-Qian Bai; Jiang-Hui Chen; Ze-Wen Song; Bo Feng; Xue-Kun Liu (Molecular Diversity, 2021)

Diversity, metabolism and cultivation of archaea in mangrove ecosystems - Cui-Jing Zhang; Yu-Lian Chen; Yi-Hua Sun; Jie Pan; Ming-Wei Cai; Meng Li (Marine Life Science & Technology, 2021)

A Pyrene-Based Fluorescent Probe for Specific Detection of Cysteine and its Application in Living Cell - Jianbin Chao; Zhuo Wang; Yongbin Zhang; Fangjun Huo; Caixia Yin; Ming Li; Yuexiang Duan (Journal of Fluorescence, 2021)

Vegetation dynamics and climate variability over the past 2000 years inferred from Son Kul marsh in the western Tianshan Mountains - Dong-liang Zhang; Yao-ming Li; Kai-hui Li; Xue-xi Ma; Yun-peng Yang (Journal of Mountain Science, 2021)

High microbial diversity stabilizes the responses of soil organic carbon decomposition to warming in the subsoil on the Tibetan Plateau - Meng Xu; Xiaoliang Li; Thomas W. Kuyper; Ming Xu; Xiaolin Li; Junling Zhang (Global Change Biology, 2021)
Soil microbes are directly involved in soil organic carbon (SOC) decomposition, yet the importance of microbial biodiversity in regulating the temperature sensitivity of SOC decomposition remains elusive, particularly in alpine regions where climate change is predicted to strongly affect SOC dynamics and ecosystem stability. Here we collected topsoil and subsoil samples along an elevational gradient on the southeastern Tibetan Plateau to explore the temperature sensitivity ( Q 10 ) of SOC decomposition in relation to changes in microbial communities. Specifically, we tested whether the decomposition of SOC would be more sensitive to warming when microbial diversity is low. The estimated Q 10 value ranged from 1.28 to 1.68, and 1.80 to 2.10 in the topsoil and subsoil, respectively. The highest Q 10 value was observed at the lowest altitude of forests in the topsoil, and at the highest altitude of alpine meadow in the subsoil. Variations in Q 10 were closely related to changes in microbial properties. In the topsoil the ratio of gram‐positive to gram‐negative bacteria (G+:G−) was the predominant factor associated with the altitudinal variations in Q 10 . In the subsoil, SOC decomposition showed more resilience to warming when the diversity of soil bacteria (both whole community and major groups) and fungi was higher. Our results partly support the positive biodiversity‐ecosystem stability hypothesis. Structural equation modeling further indicates that variations in Q 10 in the subsoil were directly related to changes in microbial diversity and community composition, which were affected by soil pH. Collectively our results provide compelling evidence that microbial biodiversity plays an important role in stabilizing SOC decomposition in the subsoil of alpine montane ecosystems. Conservation of belowground biodiversity is therefore of great importance in maintaining the stability of ecosystem processes under climate change in high‐elevation regions of the Tibetan Plateau.

Emerging role of metabolic reprogramming in tumor immune evasion and immunotherapy - Chunmei Fan; Shanshan Zhang; Zhaojian Gong; Xiayu Li; Bo Xiang; Hao Deng; Ming Zhou; Guiyuan Li; Yong Li; Wei Xiong; Zhaoyang Zeng; Xiaoling Li (Science China Life Sciences, 2021)

Introgression of phylogeography lineages of Convolvulus gortschakovii (Convolvulaceae) in the northwest China - Shu-Wen Jia; Ming-Li Zhang (Plant Systematics and Evolution, 2021)

TLR8 in the Trigeminal Ganglion Contributes to the Maintenance of Trigeminal Neuropathic Pain in Mice - Lin-Xia Zhao; Ming Jiang; Xue-Qiang Bai; De-Li Cao; Xiao-Bo Wu; Jing Zhang; Jian-Shuang Guo; Tong-Tong Chen; Juan Wang; Hao Wu; Yong-Jing Gao; Zhi-Jun Zhang (Neuroscience Bulletin, 2021)
Trigeminal neuropathic pain (TNP) is a significant health problem but the involved mechanism has not been completely elucidated. Toll-like receptors (TLRs) have recently been demonstrated to be expressed in the dorsal root ganglion and involved in chronic pain. Here, we show that TLR8 was persistently increased in the trigeminal ganglion (TG) neurons in model of TNP induced by partial infraorbital nerve ligation (pIONL). In addition, deletion or knockdown of Tlr8 in the TG attenuated pIONL-induced mechanical allodynia, reduced the activation of ERK and p38-MAPK, and decreased the expression of pro-inflammatory cytokines in the TG. Furthermore, intra-TG injection of the TLR8 agonist VTX-2337 induced pain hypersensitivity. VTX-2337 also increased the intracellular Ca 2+ concentration, induced the activation of ERK and p38, and increased the expression of pro-inflammatory cytokines in the TG. These data indicate that TLR8 contributes to the maintenance of TNP through increasing MAPK-mediated neuroinflammation. Targeting TLR8 signaling may be effective for the treatment of TNP.

Bacterial community structure in the surface sediments of different habitats of Baiyangdian Lake, Northern China: effects of nutrient conditions - Jun Chen; Jinliang Wu; Ming Liu; Liqing Li; Weijun Zhang; Dongsheng Wang; Teng Ma (Journal of Soils and Sediments, 2021)

EEG-Based Anxious States Classification Using Affective BCI-Based Closed Neurofeedback System - Chao Chen; Xuecong Yu; Abdelkader Nasreddine Belkacem; Lin Lu; Penghai Li; Zufeng Zhang; Xiaotian Wang; Wenjun Tan; Qiang Gao; Duk Shin; Changming Wang; Sha Sha; et al. (Journal of Medical and Biological Engineering, 2021)

Nitrogen removal performance and bacterial communities in zeolite trickling filter under different influent C/N ratios - Lina Liu; Na Li; Chunyang Tao; Yubo Zhao; Jingqing Gao; Zhenzhen Huang; Jingshen Zhang; Jianlei Gao; Jinliang Zhang; Ming Cai (Environmental Science and Pollution Research, 2021)

Optimize the preparation of Fe3O4-modified magnetic mesoporous biochar and its removal of methyl orange in wastewater - Jinpeng Wang; Wenyuan Chen; Ming Zhang; Runjuan Zhou; Jiyuan Li; Wei Zhao; Lixian Wang (Environmental Monitoring and Assessment, 2021)

Photocatalytic optical fibers for degradation of organic pollutants in wastewater: a review - Yongwu Wu; Lanlan Zhong; Jilin Yuan; Wenhao Xiang; Xin Xin; Huimin Liu; Hongyang Luo; Linyang Li; Ming Chen; Dengjie Zhong; Xinghong Zhang; Nianbing Zhong; et al. (Environmental Chemistry Letters, 2021)

Biotransformation of Phlorizin by Eurotium cristatum to Increase the Antioxidant and Antibacterial Activity of Docynia indica Leaves - Jie Xie; Jiang Chen; Xue-ran Mei; Ming-jun Zhu; Xue-li Li; Juan Du; Xiao-yu Zhang (Current Microbiology, 2021)

Marinobacter shengliensis subsp. alexandrii Subsp. Nov., Isolated from Cultivable Phycosphere Microbiota of Highly Toxic Dinoflagellate Alexandrium catenella LZT09 and Description of Marinobacter shengliensis Subsp. shengliensis Subsp. Nov - Xi Yang; Rong Xiang; Nurhezreen Md Iqbal; Yu-Han Duan; Xiao-Ai Zhang; Lei Wang; Lin-Zeng Yu; Jia-Zhou Li; Ming-Fei Sun; Qiao Yang; Chun-Tian Zheng; Shen-Quan Liao (Current Microbiology, 2021)

The changes of brain functional networks in young adult smokers based on independent component analysis - XianFu Wang; Ting Xue; Fang Dong; Yangding Li; Dongdong Xie; Chang Liu; Ming Zhang; Yanzhi Bi; Kai Yuan; Dahua Yu (Brain Imaging and Behavior, 2021)

Three new sesquiterpenoids with cytotoxic activity from Artemisia argyi - Li Zhang; Yong-Ming Yan; Shao-Xiang Wang; Zhe Ren; Yong-Xian Cheng (Natural Product Research, 2021)

Effects of habitat fragmentation on the demography of the critically endangered tree Pterospermum kingtungense (Sterculiaceae) in Yunnan, China - Chun-Ming Yuan; Shan-Shan Zhang; Guo-Ping Yang; Jian Chen; Yun-Fen Geng; Xiao-Shuang Li; Wen-Zhong Yang (Tropical Ecology, 2021)

Evaluating Neurodevelopmental Consequences of Perinatal Exposure to Antiretroviral Drugs: Current Challenges and New Approaches - Jordan G. Schnoll; Brian Temsamrit; Daniel Zhang; Hongjun Song; Guo-li Ming; Kimberly M. Christian (Journal of Neuroimmune Pharmacology, 2021)

High-Specific Fluorescence Probe for SO32− Detection and Bioimaging - Jianbin Chao; Jiamin Zhao; Yongbin Zhang; Fangjun Huo; Caixia Yin; Ming Li; Yuexiang Duan (Journal of Fluorescence, 2021)

Research on 3D geological modeling method based on multiple constraints - Ming Hao; Minghui Li; Jianlong Zhang; Yujie Liu; Congjun Huang; Fang Zhou (Earth Science Informatics, 2021)

Arbuscular mycorrhizal colonization rate of an exotic plant, Galinsoga quadriradiata, in mountain ranges changes with altitude - Gang Liu; Rui-Ling Liu; Wen-Gang Zhang; Ying-Bo Yang; Xiao-Qiong Bi; Ming-Zhu Li; Xiao-Yan Chen; Hua Nie; Zhi-Hong Zhu (Mycorrhiza, 2021)

Pseudomonas laoshanensis sp. nov., isolated from peanut field soil - Ming-Qing Wang; Chu-Shu Zhang; Li-Na Yu; Wei-Qiang Yang; Kun Jiao; Kui-Jie Gong; Xiao-Yuan Chi; Jie Bi; Yu Song; Qing-Li Yang; Jian-Cheng Zhang; Gui-Wen Yang; et al. (Archives of Microbiology, 2021)

Impact of the contact area between vegetation stalks and water flow on the hydraulic characteristics of sloped land - Shengtang Zhang; Ming Liu; Guibao Li; Jingzhou Zhang; Si Chen (Arabian Journal of Geosciences, 2021)

Oceanomicrobium pacificus gen. nov., sp. nov., a member of the family Rhodobacteraceae isolated from seawater of tropical western Pacific - Dadong Dai; Yangjie Li; Wenxuan He; Fang Qin; Jinshui Zheng; Ming Sun; Dechao Zhang (Antonie van Leeuwenhoek, 2021)

Spatial distribution of atmospheric bioaerosols in Beijing, Hangzhou and Wuhan, China - Xuezheng Ma; Qi Zhang; Keyang Liu; Liping Zhang; Manman Zhang; Xin Zhao; Chunya Zhou; Jinke Li; Ming Cheng; Lili Li; Kongxin Hu; Jinsong Li; et al. (Aerobiologia, 2021)

Cloning and functional characterization of auxin receptor TIR1 in Gossypium hirsutum - Yu Wu; Hainan Ming; Jing Xu; Jie Bing; Qing Chen; Qing Wang; Hongjie Li; Genfa Zhang (Acta Physiologiae Plantarum, 2021)

A single nucleotide polymorphism variant located in the cis ‐regulatory region of the ABCG2 gene is associated with mallard egg colour - Hehe Liu; Jian Hu; Zhanbao Guo; Wenlei Fan; Yaxi Xu; Suyun Liang; Dapeng Liu; Yunsheng Zhang; Ming Xie; Jing Tang; Wei Huang; Qi Zhang; et al. (Molecular Ecology, 2021)
Avian egg coloration is shaped by natural selection, but its genetic basis remains unclear. Here, we used genome‐wide association analysis and identity by descent to finely map green egg colour to a 179‐kb region of Chr4 based on the resequencing of 352 ducks ( Anas platyrhynchos ) from a segregating population resulting from the mating of Pekin ducks (white‐shelled eggs) and mallards (green‐shelled eggs). We further narrowed the candidate region to a 30‐kb interval by comparing genome divergence in seven indigenous duck populations. Among the genes located in the finely mapped region, only one transcript of the ABCG2 gene (XM_013093252.2) exhibited higher uterine expression in green‐shelled individuals than in white‐shelled individuals, as supported by transcriptome data from four populations. ABCG2 has been reported to encode a protein that functions as a membrane transporter for biliverdin. Sanger sequencing of the whole 30‐kb candidate region (Chr4: 47.41–47.44 Mb) and a plasmid reporter assay helped to identify a single nucleotide polymorphism (Chr4: 47,418,074 G>A) located in a conserved predicted promoter region whose variation may alter ABCG2 transcription activity. We provide a useful molecular marker for duck breeding and contribute data to the research on ecological evolution based on egg colour patterns among birds.

QTL mapping for foxtail millet plant height in multi-environment using an ultra-high density bin map - Qiang He; Hui Zhi; Sha Tang; Lu Xing; Suying Wang; Haigang Wang; Aiying Zhang; Yuhui Li; Ming Gao; Haijin Zhang; Guoqiu Chen; Shutao Dai; et al. (Theoretical and Applied Genetics, 2021)

Pathological matrix stiffness promotes cardiac fibroblast differentiation through the POU2F1 signaling pathway - Mingzhe Li; Jimin Wu; Guomin Hu; Yao Song; Jing Shen; Junzhou Xin; Zijian Li; Wei Liu; Erdan Dong; Ming Xu; Youyi Zhang; Han Xiao (Science China Life Sciences, 2021)

GmNAC06, a NAC domain transcription factor enhances salt stress tolerance in soybean - Ming Li; Rui Chen; Qiyan Jiang; Xianjun Sun; Hui Zhang; Zheng Hu (Plant Molecular Biology, 2021)
Key message We found GmNAC06 plays an important role in salt stress responses through the phenotypic, physiological and molecular analyses of OE, VC, and Mutant composite soybean. Abstract Salinization affects 20% of all cultivated land worldwide because of the high salinity of irrigation water and the excessive use of water, and this amount is increasing daily. NAC (NAM, ATAF, and CUC) have been found to be involved in salt stress. In this study, a soybean NAC gene, GmNAC06 (Glyma06g21020.1), was cloned and functionally characterized. The results of expression analysis suggested that salt stress could influence the expression level of GmNAC06 . The subcellular localization analysis results suggested that GmNAC06 may function as a transcription factor. Under salt stress, the overexpression technology combined with CRISPR-Cas9 system found that GmNAC06 could cause the accumulation of proline and glycine betaine to alleviate or avoid the negative effects of ROS; similarly, it could control the Na + /K + ratios in hairy roots to maintain ionic homeostasis. The fresh weight of the transgenic hairy roots and the histochemical ROS staining of wild leaves suggested that transgenic hairy roots influence the function of wild leaves under salt stress conditions. Moreover, the expression levels of GmUBC2 and GmHKT1 were higher in the GmNAC06 hairy roots than in the control. Thus, the overexpression of GmNAC06 in hairy roots notably causes an entire composite plant to exhibit salt tolerance. The phenotype of composite soybean plants and transgenic Arabidopsis plants suggest that GmNAC06 plays a role in response to salt stress and could be useful in generating salt tolerant transgenic crops.

Down-regulation of MANNANASE7 gene in Brassica napus L. enhances silique dehiscence-resistance - Yu-Long Li; Yan-Kun Yu; Ke-Ming Zhu; Li-Na Ding; Zheng Wang; Yan-Hua Yang; Jun Cao; Li-Zhang Xu; Yao-Ming Li; Xiao-Li Tan (Plant Cell Reports, 2021)

Primary fluid exsolution in porphyry copper systems: evidence from magmatic apatite and anhydrite inclusions in zircon - Jin-Xiang Li; Guang-Ming Li; Noreen J. Evans; Jun-Xing Zhao; Ke-Zhang Qin; Jing Xie (Mineralium Deposita, 2021)

Modes of genetic adaptations underlying functional innovations in the rumen - Xiangyu Pan; Yudong Cai; Zongjun Li; Xianqing Chen; Rasmus Heller; Nini Wang; Yu Wang; Chen Zhao; Yong Wang; Han Xu; Songhai Li; Ming Li; et al. (Science China Life Sciences, 2021)